                         SEQUENCE LISTING

<110>  Universitt des Saarlandes
 
<120>  An in-vitro method or assay for detecting a tumor or a cancerous 
       disease by screening for antibodies

<130>  P22221WO

<150>  EP 08 170 564.2
<151>  2008-12-03

<160>  18    

<170>  PatentIn version 3.3

<210>  1
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys 
    50                  55                  60                  


Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys 
65                  70                  75                  80  


Lys Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu 
                85                  90                  95      


Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala 
                165                 170                 175     


Asn Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu 
            180                 185                 190         


Lys Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu 
    210                 215                 220                 


Glu Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser 
            260                 265                 270         


Pro Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp 
    290                 295                 300                 


Gln Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ser Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu 
                405                 410                 415     


Leu Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu 
            420                 425                 430         


Ala Lys 
        


<210>  2
<211>  1474
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Arg Leu Ala Ala Val Leu Trp Asn Leu Cys Val Thr Ala Val 
1               5                   10                  15      


Leu Val Thr Ser Ala Thr Gln Gly Leu Ser Arg Ala Gly Leu Pro Phe 
            20                  25                  30          


Gly Leu Met Arg Arg Glu Leu Ala Cys Glu Gly Tyr Pro Ile Glu Leu 
        35                  40                  45              


Arg Cys Pro Gly Ser Asp Val Ile Met Val Glu Asn Ala Asn Tyr Gly 
    50                  55                  60                  


Arg Thr Asp Asp Lys Ile Cys Asp Ala Asp Pro Phe Gln Met Glu Asn 
65                  70                  75                  80  


Val Gln Cys Tyr Leu Pro Asp Ala Phe Lys Ile Met Ser Gln Arg Cys 
                85                  90                  95      


Asn Asn Arg Thr Gln Cys Val Val Val Ala Gly Ser Asp Ala Phe Pro 
            100                 105                 110         


Asp Pro Cys Pro Gly Thr Tyr Lys Tyr Leu Glu Val Gln Tyr Asp Cys 
        115                 120                 125             


Val Pro Tyr Lys Val Glu Gln Lys Val Phe Val Cys Pro Gly Thr Leu 
    130                 135                 140                 


Gln Lys Val Leu Glu Pro Thr Ser Thr His Glu Ser Glu His Gln Ser 
145                 150                 155                 160 


Gly Ala Trp Cys Lys Asp Pro Leu Gln Ala Gly Asp Arg Ile Tyr Val 
                165                 170                 175     


Met Pro Trp Ile Pro Tyr Arg Thr Asp Thr Leu Thr Glu Tyr Ala Ser 
            180                 185                 190         


Trp Glu Asp Tyr Val Ala Ala Arg His Thr Thr Thr Tyr Arg Leu Pro 
        195                 200                 205             


Asn Arg Val Asp Gly Thr Gly Phe Val Val Tyr Asp Gly Ala Val Phe 
    210                 215                 220                 


Tyr Asn Lys Glu Arg Thr Arg Asn Ile Val Lys Tyr Asp Leu Arg Thr 
225                 230                 235                 240 


Arg Ile Lys Ser Gly Glu Thr Val Ile Asn Thr Ala Asn Tyr His Asp 
                245                 250                 255     


Thr Ser Pro Tyr Arg Trp Gly Gly Lys Thr Asp Ile Asp Leu Ala Val 
            260                 265                 270         


Asp Glu Asn Gly Leu Trp Val Ile Tyr Ala Thr Glu Gly Asn Asn Gly 
        275                 280                 285             


Arg Leu Val Val Ser Gln Leu Asn Pro Tyr Thr Leu Arg Phe Glu Gly 
    290                 295                 300                 


Thr Trp Glu Thr Gly Tyr Asp Lys Arg Ser Ala Ser Asn Ala Phe Met 
305                 310                 315                 320 


Val Cys Gly Val Leu Tyr Val Leu Arg Ser Val Tyr Val Asp Asp Asp 
                325                 330                 335     


Ser Glu Ala Ala Gly Asn Arg Val Asp Tyr Ala Phe Asn Thr Asn Ala 
            340                 345                 350         


Asn Arg Glu Glu Pro Val Ser Leu Thr Phe Pro Asn Pro Tyr Gln Phe 
        355                 360                 365             


Ile Ser Ser Val Asp Tyr Asn Pro Arg Asp Asn Gln Leu Tyr Val Trp 
    370                 375                 380                 


Asn Asn Tyr Phe Val Val Arg Tyr Ser Leu Glu Phe Gly Pro Pro Asp 
385                 390                 395                 400 


Pro Ser Ala Gly Pro Ala Thr Ser Pro Pro Leu Ser Thr Thr Thr Thr 
                405                 410                 415     


Ala Arg Pro Thr Pro Leu Thr Ser Thr Ala Ser Pro Ala Ala Thr Thr 
            420                 425                 430         


Pro Leu Arg Arg Ala Pro Leu Thr Thr His Pro Val Gly Ala Ile Asn 
        435                 440                 445             


Gln Leu Gly Pro Asp Leu Pro Pro Ala Thr Ala Pro Val Pro Ser Thr 
    450                 455                 460                 


Arg Arg Pro Pro Ala Pro Asn Leu His Val Ser Pro Glu Leu Phe Cys 
465                 470                 475                 480 


Glu Pro Arg Glu Val Arg Arg Val Gln Trp Pro Ala Thr Gln Gln Gly 
                485                 490                 495     


Met Leu Val Glu Arg Pro Cys Pro Lys Gly Thr Arg Gly Ile Ala Ser 
            500                 505                 510         


Phe Gln Cys Leu Pro Ala Leu Gly Leu Trp Asn Pro Arg Gly Pro Asp 
        515                 520                 525             


Leu Ser Asn Cys Thr Ser Pro Trp Val Asn Gln Val Ala Gln Lys Ile 
    530                 535                 540                 


Lys Ser Gly Glu Asn Ala Ala Asn Ile Ala Ser Glu Leu Ala Arg His 
545                 550                 555                 560 


Thr Arg Gly Ser Ile Tyr Ala Gly Asp Val Ser Ser Ser Val Lys Leu 
                565                 570                 575     


Met Glu Gln Leu Leu Asp Ile Leu Asp Ala Gln Leu Gln Ala Leu Arg 
            580                 585                 590         


Pro Ile Glu Arg Glu Ser Ala Gly Lys Asn Tyr Asn Lys Met His Lys 
        595                 600                 605             


Arg Glu Arg Thr Cys Lys Asp Tyr Ile Lys Ala Val Val Glu Thr Val 
    610                 615                 620                 


Asp Asn Leu Leu Arg Pro Glu Ala Leu Glu Ser Trp Lys Asp Met Asn 
625                 630                 635                 640 


Ala Thr Glu Gln Val His Thr Ala Thr Met Leu Leu Asp Val Leu Glu 
                645                 650                 655     


Glu Gly Ala Phe Leu Leu Ala Asp Asn Val Arg Glu Pro Ala Arg Phe 
            660                 665                 670         


Leu Ala Ala Lys Glu Asn Val Val Leu Glu Val Thr Val Leu Asn Thr 
        675                 680                 685             


Glu Gly Gln Val Gln Glu Leu Val Phe Pro Gln Glu Glu Tyr Pro Arg 
    690                 695                 700                 


Lys Asn Ser Ile Gln Leu Ser Ala Lys Thr Ile Lys Gln Asn Ser Arg 
705                 710                 715                 720 


Asn Gly Val Val Lys Val Val Phe Ile Leu Tyr Asn Asn Leu Gly Leu 
                725                 730                 735     


Phe Leu Ser Thr Glu Asn Ala Thr Val Lys Leu Ala Gly Glu Ala Gly 
            740                 745                 750         


Pro Gly Gly Pro Gly Gly Ala Ser Leu Val Val Asn Ser Gln Val Ile 
        755                 760                 765             


Ala Ala Ser Ile Asn Lys Glu Ser Ser Arg Val Phe Leu Met Asp Pro 
    770                 775                 780                 


Val Ile Phe Thr Val Ala His Leu Glu Asp Lys Asn His Phe Asn Ala 
785                 790                 795                 800 


Asn Cys Ser Phe Trp Asn Tyr Ser Glu Arg Ser Met Leu Gly Tyr Trp 
                805                 810                 815     


Ser Thr Gln Gly Cys Arg Leu Val Glu Ser Asn Lys Thr His Thr Thr 
            820                 825                 830         


Cys Ala Cys Ser His Leu Thr Asn Phe Ala Val Leu Met Ala His Arg 
        835                 840                 845             


Glu Ile Tyr Gln Gly Arg Ile Asn Glu Leu Leu Leu Ser Val Ile Thr 
    850                 855                 860                 


Trp Val Gly Ile Val Ile Ser Leu Val Cys Leu Ala Ile Cys Ile Ser 
865                 870                 875                 880 


Thr Phe Cys Phe Leu Arg Gly Leu Gln Thr Asp Arg Asn Thr Ile His 
                885                 890                 895     


Lys Asn Leu Cys Ile Asn Leu Phe Leu Ala Glu Leu Leu Phe Leu Val 
            900                 905                 910         


Gly Ile Asp Lys Thr Gln Tyr Glu Ile Ala Cys Pro Ile Phe Ala Gly 
        915                 920                 925             


Leu Leu His Tyr Phe Phe Leu Ala Ala Phe Ser Trp Leu Cys Leu Glu 
    930                 935                 940                 


Gly Val His Leu Tyr Leu Leu Leu Val Glu Val Phe Glu Ser Glu Tyr 
945                 950                 955                 960 


Ser Arg Thr Lys Tyr Tyr Tyr Leu Gly Gly Tyr Cys Phe Pro Ala Leu 
                965                 970                 975     


Val Val Gly Ile Ala Ala Ala Ile Asp Tyr Arg Ser Tyr Gly Thr Glu 
            980                 985                 990         


Lys Ala Cys Trp Leu Arg Val Asp  Asn Tyr Phe Ile Trp  Ser Phe Ile 
        995                 1000                 1005             


Gly Pro  Val Ser Phe Val Ile  Val Val Asn Leu Val  Phe Leu Met 
    1010                 1015                 1020             


Val Thr  Leu His Lys Met Ile  Arg Ser Ser Ser Val  Leu Lys Pro 
    1025                 1030                 1035             


Asp Ser  Ser Arg Leu Asp Asn  Ile Lys Ser Trp Ala  Leu Gly Ala 
    1040                 1045                 1050             


Ile Ala  Leu Leu Phe Leu Leu  Gly Leu Thr Trp Ala  Phe Gly Leu 
    1055                 1060                 1065             


Leu Phe  Ile Asn Lys Glu Ser  Val Val Met Ala Tyr  Leu Phe Thr 
    1070                 1075                 1080             


Thr Phe  Asn Ala Phe Gln Gly  Val Phe Ile Phe Val  Phe His Cys 
    1085                 1090                 1095             


Ala Leu  Gln Lys Lys Val His  Lys Glu Tyr Ser Lys  Cys Leu Arg 
    1100                 1105                 1110             


His Ser  Tyr Cys Cys Ile Arg  Ser Pro Pro Gly Gly  Thr His Gly 
    1115                 1120                 1125             


Ser Leu  Lys Thr Ser Ala Met  Arg Ser Asn Thr Arg  Tyr Tyr Thr 
    1130                 1135                 1140             


Gly Thr  Gln Ser Arg Ile Arg  Arg Met Trp Asn Asp  Thr Val Arg 
    1145                 1150                 1155             


Lys Gln  Thr Glu Ser Ser Phe  Met Ala Gly Asp Ile  Asn Ser Thr 
    1160                 1165                 1170             


Pro Thr  Leu Asn Arg Gly Thr  Met Gly Asn His Leu  Leu Thr Asn 
    1175                 1180                 1185             


Pro Val  Leu Gln Pro Arg Gly  Gly Thr Ser Pro Tyr  Asn Thr Leu 
    1190                 1195                 1200             


Ile Ala  Glu Ser Val Gly Phe  Asn Pro Ser Ser Pro  Pro Val Phe 
    1205                 1210                 1215             


Asn Ser  Pro Gly Ser Tyr Arg  Glu Pro Lys His Pro  Leu Gly Gly 
    1220                 1225                 1230             


Arg Glu  Ala Cys Gly Met Asp  Thr Leu Pro Leu Asn  Gly Asn Phe 
    1235                 1240                 1245             


Asn Asn  Ser Tyr Ser Leu Arg  Ser Gly Asp Phe Pro  Pro Gly Asp 
    1250                 1255                 1260             


Gly Gly  Pro Glu Pro Pro Arg  Gly Arg Asn Leu Ala  Asp Ala Ala 
    1265                 1270                 1275             


Ala Phe  Glu Lys Met Ile Ile  Ser Glu Leu Val His  Asn Asn Leu 
    1280                 1285                 1290             


Arg Gly  Ser Ser Ser Ala Ala  Lys Gly Pro Pro Pro  Pro Glu Pro 
    1295                 1300                 1305             


Pro Val  Pro Pro Val Pro Gly  Gly Gly Gly Glu Glu  Glu Ala Gly 
    1310                 1315                 1320             


Gly Pro  Gly Gly Ala Asp Arg  Ala Glu Ile Glu Leu  Leu Tyr Lys 
    1325                 1330                 1335             


Ala Leu  Glu Glu Pro Leu Leu  Leu Pro Arg Ala Gln  Ser Val Leu 
    1340                 1345                 1350             


Tyr Gln  Ser Asp Leu Asp Glu  Ser Glu Ser Cys Thr  Ala Glu Asp 
    1355                 1360                 1365             


Gly Ala  Thr Ser Arg Pro Leu  Ser Ser Pro Pro Gly  Arg Asp Ser 
    1370                 1375                 1380             


Leu Tyr  Ala Ser Gly Ala Asn  Leu Arg Asp Ser Pro  Ser Tyr Pro 
    1385                 1390                 1395             


Asp Ser  Ser Pro Glu Gly Pro  Ser Glu Ala Leu Pro  Pro Pro Pro 
    1400                 1405                 1410             


Pro Ala  Pro Pro Gly Pro Pro  Glu Ile Tyr Tyr Thr  Ser Arg Pro 
    1415                 1420                 1425             


Pro Ala  Leu Val Ala Arg Asn  Pro Leu Gln Gly Tyr  Tyr Gln Val 
    1430                 1435                 1440             


Arg Arg  Pro Ser His Glu Gly  Tyr Leu Ala Ala Pro  Gly Leu Glu 
    1445                 1450                 1455             


Gly Pro  Gly Pro Asp Gly Asp  Gly Gln Met Gln Leu  Val Thr Ser 
    1460                 1465                 1470             


Leu 
    


<210>  3
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Thr Ala Asn Gly Thr Ala Glu Ala Val Gln Ile Gln Phe Gly Leu 
1               5                   10                  15      


Ile Asn Cys Gly Asn Lys Tyr Leu Thr Ala Glu Ala Phe Gly Phe Lys 
            20                  25                  30          


Val Asn Ala Ser Ala Ser Ser Leu Lys Lys Lys Gln Ile Trp Thr Leu 
        35                  40                  45              


Glu Gln Pro Pro Asp Glu Ala Gly Ser Ala Ala Val Cys Leu Arg Ser 
    50                  55                  60                  


His Leu Gly Arg Tyr Leu Ala Ala Asp Lys Asp Gly Asn Val Thr Cys 
65                  70                  75                  80  


Glu Arg Glu Val Pro Gly Pro Asp Cys Arg Phe Leu Ile Val Ala His 
                85                  90                  95      


Asp Asp Gly Arg Trp Ser Leu Gln Ser Glu Ala His Arg Arg Tyr Phe 
            100                 105                 110         


Gly Gly Thr Glu Asp Arg Leu Ser Cys Phe Ala Gln Thr Val Ser Pro 
        115                 120                 125             


Ala Glu Lys Trp Ser Val His Ile Ala Met His Pro Gln Val Asn Ile 
    130                 135                 140                 


Tyr Ser Val Thr Arg Lys Arg Tyr Ala His Leu Ser Ala Arg Pro Ala 
145                 150                 155                 160 


Asp Glu Ile Ala Val Asp Arg Asp Val Pro Trp Gly Val Asp Ser Leu 
                165                 170                 175     


Ile Thr Leu Ala Phe Gln Asp Gln Arg Tyr Ser Val Gln Thr Ala Asp 
            180                 185                 190         


His Arg Phe Leu Arg His Asp Gly Arg Leu Val Ala Arg Pro Glu Pro 
        195                 200                 205             


Ala Thr Gly Tyr Thr Leu Glu Phe Arg Ser Gly Lys Val Ala Phe Arg 
    210                 215                 220                 


Asp Cys Glu Gly Arg Tyr Leu Ala Pro Ser Gly Pro Ser Gly Thr Leu 
225                 230                 235                 240 


Lys Ala Gly Lys Ala Thr Lys Val Gly Lys Asp Glu Leu Phe Ala Leu 
                245                 250                 255     


Glu Gln Ser Cys Ala Gln Val Val Leu Gln Ala Ala Asn Glu Arg Asn 
            260                 265                 270         


Val Ser Thr Arg Gln Gly Met Asp Leu Ser Ala Asn Gln Asp Glu Glu 
        275                 280                 285             


Thr Asp Gln Glu Thr Phe Gln Leu Glu Ile Asp Arg Asp Thr Lys Lys 
    290                 295                 300                 


Cys Ala Phe Arg Thr His Thr Gly Lys Tyr Trp Thr Leu Thr Ala Thr 
305                 310                 315                 320 


Gly Gly Val Gln Ser Thr Ala Ser Ser Lys Asn Ala Ser Cys Tyr Phe 
                325                 330                 335     


Asp Ile Glu Trp Arg Asp Arg Arg Ile Thr Leu Arg Ala Ser Asn Gly 
            340                 345                 350         


Lys Phe Val Thr Ser Lys Lys Asn Gly Gln Leu Ala Ala Ser Val Glu 
        355                 360                 365             


Thr Ala Gly Asp Ser Glu Leu Phe Leu Met Lys Leu Ile Asn Arg Pro 
    370                 375                 380                 


Ile Ile Val Phe Arg Gly Glu His Gly Phe Ile Gly Cys Arg Lys Val 
385                 390                 395                 400 


Thr Gly Thr Leu Asp Ala Asn Arg Ser Ser Tyr Asp Val Phe Gln Leu 
                405                 410                 415     


Glu Phe Asn Asp Gly Ala Tyr Asn Ile Lys Asp Ser Thr Gly Lys Tyr 
            420                 425                 430         


Trp Thr Val Gly Ser Asp Ser Ala Val Thr Ser Ser Gly Asp Thr Pro 
        435                 440                 445             


Val Asp Phe Phe Phe Glu Phe Cys Asp Tyr Asn Lys Val Ala Ile Lys 
    450                 455                 460                 


Val Gly Gly Arg Tyr Leu Lys Gly Asp His Ala Gly Val Leu Lys Ala 
465                 470                 475                 480 


Ser Ala Glu Thr Val Asp Pro Ala Ser Leu Trp Glu Tyr 
                485                 490             


<210>  4
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Thr Arg Ser Val Ser Ser Ser Ser Tyr Arg Arg Met Phe Gly 
1               5                   10                  15      


Gly Pro Gly Thr Ala Ser Arg Pro Ser Ser Ser Arg Ser Tyr Val Thr 
            20                  25                  30          


Thr Ser Thr Arg Thr Tyr Ser Leu Gly Ser Ala Leu Arg Pro Ser Thr 
        35                  40                  45              


Ser Arg Ser Leu Tyr Ala Ser Ser Pro Gly Gly Val Tyr Ala Thr Arg 
    50                  55                  60                  


Ser Ser Ala Val Arg Leu Arg Ser Ser Val Pro Gly Val Arg Leu Leu 
65                  70                  75                  80  


Gln Asp Ser Val Asp Phe Ser Leu Ala Asp Ala Ile Asn Thr Glu Phe 
                85                  90                  95      


Lys Asn Thr Arg Thr Asn Glu Lys Val Glu Leu Gln Glu Leu Asn Asp 
            100                 105                 110         


Arg Phe Ala Asn Tyr Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn 
        115                 120                 125             


Lys Ile Leu Leu Ala Glu Leu Glu Gln Leu Lys Gly Gln Gly Lys Ser 
    130                 135                 140                 


Arg Leu Gly Asp Leu Tyr Glu Glu Glu Met Arg Glu Leu Arg Arg Gln 
145                 150                 155                 160 


Val Asp Gln Leu Thr Asn Asp Lys Ala Arg Val Glu Val Glu Arg Asp 
                165                 170                 175     


Asn Leu Ala Glu Asp Ile Met Arg Leu Arg Glu Lys Leu Gln Glu Glu 
            180                 185                 190         


Met Leu Gln Arg Glu Glu Ala Glu Asn Thr Leu Gln Ser Phe Arg Gln 
        195                 200                 205             


Asp Val Asp Asn Ala Ser Leu Ala Arg Leu Asp Leu Glu Arg Lys Val 
    210                 215                 220                 


Glu Ser Leu Gln Glu Glu Ile Ala Phe Leu Lys Lys Leu His Glu Glu 
225                 230                 235                 240 


Glu Ile Gln Glu Leu Gln Ala Gln Ile Gln Glu Gln His Val Gln Ile 
                245                 250                 255     


Asp Val Asp Val Ser Lys Pro Asp Leu Thr Ala Ala Leu Arg Asp Val 
            260                 265                 270         


Arg Gln Gln Tyr Glu Ser Val Ala Ala Lys Asn Leu Gln Glu Ala Glu 
        275                 280                 285             


Glu Trp Tyr Lys Ser Lys Phe Ala Asp Leu Ser Glu Ala Ala Asn Arg 
    290                 295                 300                 


Asn Asn Asp Ala Leu Arg Gln Ala Lys Gln Glu Ser Thr Glu Tyr Arg 
305                 310                 315                 320 


Arg Gln Val Gln Ser Leu Thr Cys Glu Val Asp Ala Leu Lys Gly Thr 
                325                 330                 335     


Asn Glu Ser Leu Glu Arg Gln Met Arg Glu Met Glu Glu Asn Phe Ala 
            340                 345                 350         


Val Glu Ala Ala Asn Tyr Gln Asp Thr Ile Gly Arg Leu Gln Asp Glu 
        355                 360                 365             


Ile Gln Asn Met Lys Glu Glu Met Ala Arg His Leu Arg Glu Tyr Gln 
    370                 375                 380                 


Asp Leu Leu Asn Val Lys Met Ala Leu Asp Ile Glu Ile Ala Thr Tyr 
385                 390                 395                 400 


Arg Lys Leu Leu Glu Gly Glu Glu Ser Arg Ile Ser Leu Pro Leu Pro 
                405                 410                 415     


Asn Phe Ser Ser Leu Asn Leu Arg Glu Thr Asn Leu Asp Ser Leu Pro 
            420                 425                 430         


Leu Val Asp Thr His Ser Lys Arg Thr Leu Leu Ile Lys Thr Val Glu 
        435                 440                 445             


Thr Arg Asp Gly Gln Val Ile Asn Glu Thr Ser Gln His His Asp Asp 
    450                 455                 460                 


Leu Glu 
465     


<210>  5
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Val Asp Met Met Asp Leu Pro Arg Ser Arg Ile Asn Ala Gly Met 
1               5                   10                  15      


Leu Ala Gln Phe Ile Asp Lys Pro Val Cys Phe Val Gly Arg Leu Glu 
            20                  25                  30          


Lys Ile His Pro Thr Gly Lys Met Phe Ile Leu Ser Asp Gly Glu Gly 
        35                  40                  45              


Lys Asn Gly Thr Ile Glu Leu Met Glu Pro Leu Asp Glu Glu Ile Ser 
    50                  55                  60                  


Gly Ile Val Glu Val Val Gly Arg Val Thr Ala Lys Ala Thr Ile Leu 
65                  70                  75                  80  


Cys Thr Ser Tyr Val Gln Phe Lys Glu Asp Ser His Pro Phe Asp Leu 
                85                  90                  95      


Gly Leu Tyr Asn Glu Ala Val Lys Ile Ile His Asp Phe Pro Gln Phe 
            100                 105                 110         


Tyr Pro Leu Gly Ile Val Gln His Asp 
        115                 120     


<210>  6
<211>  919
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Ala Pro Glu Tyr Leu Asp Leu Asp Glu Ile Asp Phe Ser Asp 
1               5                   10                  15      


Asp Ile Ser Tyr Ser Val Thr Ser Leu Lys Thr Ile Pro Glu Leu Cys 
            20                  25                  30          


Arg Arg Cys Asp Thr Gln Asn Glu Asp Arg Ser Val Ser Ser Ser Ser 
        35                  40                  45              


Trp Asn Cys Gly Ile Ser Thr Leu Ile Thr Asn Thr Gln Lys Pro Thr 
    50                  55                  60                  


Gly Ile Ala Asp Val Tyr Ser Lys Phe Arg Pro Val Lys Arg Val Ser 
65                  70                  75                  80  


Pro Leu Lys His Gln Pro Glu Thr Leu Glu Asn Asn Glu Ser Asp Asp 
                85                  90                  95      


Gln Lys Asn Gln Lys Val Val Glu Tyr Gln Lys Gly Gly Glu Ser Asp 
            100                 105                 110         


Leu Gly Pro Gln Pro Gln Glu Leu Gly Pro Gly Asp Gly Val Gly Gly 
        115                 120                 125             


Pro Pro Gly Lys Ser Ser Glu Pro Ser Thr Ser Leu Gly Glu Leu Glu 
    130                 135                 140                 


His Tyr Asp Leu Asp Met Asp Glu Ile Leu Asp Val Pro Tyr Ile Lys 
145                 150                 155                 160 


Ser Ser Gln Gln Leu Ala Ser Phe Thr Lys Val Thr Ser Glu Lys Arg 
                165                 170                 175     


Ile Leu Gly Leu Cys Thr Thr Ile Asn Gly Leu Ser Gly Lys Ala Cys 
            180                 185                 190         


Ser Thr Gly Ser Ser Glu Ser Ser Ser Ser Asn Met Ala Pro Phe Cys 
        195                 200                 205             


Val Leu Ser Pro Val Lys Ser Pro His Leu Arg Lys Ala Ser Ala Val 
    210                 215                 220                 


Ile His Asp Gln His Lys Leu Ser Thr Glu Glu Thr Glu Ile Ser Pro 
225                 230                 235                 240 


Pro Leu Val Lys Cys Gly Ser Ala Tyr Glu Pro Glu Asn Gln Ser Lys 
                245                 250                 255     


Asp Phe Leu Asn Lys Thr Phe Ser Asp Pro His Gly Arg Lys Val Glu 
            260                 265                 270         


Lys Thr Thr Pro Asp Cys Gln Leu Arg Ala Phe His Leu Gln Ser Ser 
        275                 280                 285             


Ala Ala Glu Ser Lys Pro Glu Glu Gln Val Ser Gly Leu Asn Arg Thr 
    290                 295                 300                 


Ser Ser Gln Gly Pro Glu Glu Arg Ser Glu Tyr Leu Lys Lys Val Lys 
305                 310                 315                 320 


Ser Ile Leu Asn Ile Val Lys Glu Gly Gln Ile Ser Leu Leu Pro His 
                325                 330                 335     


Leu Ala Ala Asp Asn Leu Asp Lys Ile His Asp Glu Asn Gly Asn Asn 
            340                 345                 350         


Leu Leu His Ile Ala Ala Ser Gln Gly His Ala Glu Cys Leu Gln His 
        355                 360                 365             


Leu Thr Ser Leu Met Gly Glu Asp Cys Leu Asn Glu Arg Asn Thr Glu 
    370                 375                 380                 


Lys Leu Thr Pro Ala Gly Leu Ala Ile Lys Asn Gly Gln Leu Glu Cys 
385                 390                 395                 400 


Val Arg Trp Met Val Ser Glu Thr Glu Ala Ile Ala Glu Leu Ser Cys 
                405                 410                 415     


Ser Lys Asp Phe Pro Ser Leu Ile His Tyr Ala Gly Cys Tyr Gly Gln 
            420                 425                 430         


Glu Lys Ile Leu Leu Trp Leu Leu Gln Phe Met Gln Glu Gln Gly Ile 
        435                 440                 445             


Ser Leu Asp Glu Val Asp Gln Asp Gly Asn Ser Ala Val His Val Ala 
    450                 455                 460                 


Ser Gln His Gly Tyr Leu Gly Cys Ile Gln Thr Leu Val Glu Tyr Gly 
465                 470                 475                 480 


Ala Asn Val Thr Met Gln Asn His Ala Gly Glu Lys Pro Ser Gln Ser 
                485                 490                 495     


Ala Glu Arg Gln Gly His Thr Leu Cys Ser Arg Tyr Leu Val Val Val 
            500                 505                 510         


Glu Thr Cys Met Ser Leu Ala Ser Gln Val Val Lys Leu Thr Lys Gln 
        515                 520                 525             


Leu Lys Glu Gln Thr Val Glu Arg Val Thr Leu Gln Asn Gln Leu Gln 
    530                 535                 540                 


Gln Phe Leu Glu Ala Gln Lys Ser Glu Gly Lys Ser Leu Pro Ser Ser 
545                 550                 555                 560 


Pro Ser Ser Pro Ser Ser Pro Ala Ser Arg Lys Ser Gln Trp Lys Ser 
                565                 570                 575     


Pro Asp Ala Asp Asp Asp Ser Val Ala Lys Ser Lys Pro Gly Val Gln 
            580                 585                 590         


Glu Gly Ile Gln Val Leu Gly Ser Leu Ser Ala Ser Ser Arg Ala Arg 
        595                 600                 605             


Pro Lys Ala Lys Asp Glu Asp Ser Asp Lys Ile Leu Arg Gln Leu Leu 
    610                 615                 620                 


Gly Lys Glu Ile Ser Glu Asn Val Cys Thr Gln Glu Lys Leu Ser Leu 
625                 630                 635                 640 


Glu Phe Gln Asp Ala Gln Ala Ser Ser Arg Asn Ser Lys Lys Ile Pro 
                645                 650                 655     


Leu Glu Lys Arg Glu Leu Lys Leu Ala Arg Leu Arg Gln Leu Met Gln 
            660                 665                 670         


Arg Ser Leu Ser Glu Ser Asp Thr Asp Ser Asn Asn Ser Glu Asp Pro 
        675                 680                 685             


Lys Thr Thr Pro Val Arg Lys Ala Asp Arg Pro Arg Pro Gln Pro Ile 
    690                 695                 700                 


Val Glu Ser Val Glu Ser Met Asp Ser Ala Glu Ser Leu His Leu Met 
705                 710                 715                 720 


Ile Lys Lys His Thr Leu Ala Ser Gly Gly Arg Arg Phe Pro Phe Ser 
                725                 730                 735     


Ile Lys Ala Ser Lys Ser Leu Asp Gly His Ser Pro Ser Pro Thr Ser 
            740                 745                 750         


Glu Ser Ser Glu Pro Asp Leu Glu Ser Gln Tyr Pro Gly Ser Gly Ser 
        755                 760                 765             


Ile Pro Pro Asn Gln Pro Ser Gly Asp Pro Gln Gln Pro Ser Pro Asp 
    770                 775                 780                 


Ser Thr Ala Ala Gln Lys Val Ala Thr Ser Pro Lys Ser Ala Leu Lys 
785                 790                 795                 800 


Ser Pro Ser Ser Lys Arg Arg Thr Ser Gln Asn Leu Lys Leu Arg Val 
                805                 810                 815     


Thr Phe Glu Glu Pro Val Val Gln Met Glu Gln Pro Ser Leu Glu Leu 
            820                 825                 830         


Asn Gly Glu Lys Asp Lys Asp Lys Gly Arg Thr Leu Gln Arg Thr Ser 
        835                 840                 845             


Thr Ser Asn Glu Ser Gly Asp Gln Leu Lys Arg Pro Phe Gly Ala Phe 
    850                 855                 860                 


Arg Ser Ile Met Glu Thr Leu Ser Gly Asn Gln Asn Asn Asn Asn Asn 
865                 870                 875                 880 


Tyr Gln Ala Ala Asn Gln Leu Lys Thr Ser Thr Leu Pro Leu Thr Ser 
                885                 890                 895     


Leu Gly Arg Lys Thr Asp Ala Lys Gly Asn Pro Ala Ser Ser Ala Ser 
            900                 905                 910         


Lys Gly Lys Asn Lys Ala Ala 
        915                 


<210>  7
<211>  621
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Asn Val Pro Trp Ala Glu Val Cys Glu Lys Phe Gln Ala Ala 
1               5                   10                  15      


Leu Ala Leu Ser Arg Val Glu Leu His Lys Asn Pro Glu Lys Glu Pro 
            20                  25                  30          


Tyr Lys Ser Lys Tyr Ser Ala Arg Ala Leu Leu Glu Glu Val Lys Ala 
        35                  40                  45              


Leu Leu Gly Pro Ala Pro Glu Asp Glu Asp Glu Arg Pro Glu Ala Glu 
    50                  55                  60                  


Asp Gly Pro Gly Ala Gly Asp His Ala Leu Gly Leu Pro Ala Glu Val 
65                  70                  75                  80  


Val Glu Pro Glu Gly Pro Val Ala Gln Arg Ala Val Arg Leu Ala Val 
                85                  90                  95      


Ile Glu Phe His Leu Gly Val Asn His Ile Asp Thr Glu Glu Leu Ser 
            100                 105                 110         


Ala Gly Glu Glu His Leu Val Lys Cys Leu Arg Leu Leu Arg Arg Tyr 
        115                 120                 125             


Arg Leu Ser His Asp Cys Ile Ser Leu Cys Ile Gln Ala Gln Asn Asn 
    130                 135                 140                 


Leu Gly Ile Leu Trp Ser Glu Arg Glu Glu Ile Glu Thr Ala Gln Ala 
145                 150                 155                 160 


Tyr Leu Glu Ser Ser Glu Ala Leu Tyr Asn Gln Tyr Met Lys Glu Val 
                165                 170                 175     


Gly Ser Pro Pro Leu Asp Pro Thr Glu Arg Phe Leu Pro Glu Glu Glu 
            180                 185                 190         


Lys Leu Thr Glu Gln Glu Arg Ser Lys Arg Phe Glu Lys Val Tyr Thr 
        195                 200                 205             


His Asn Leu Tyr Tyr Leu Ala Gln Val Tyr Gln His Leu Glu Met Phe 
    210                 215                 220                 


Glu Lys Ala Ala His Tyr Cys His Ser Thr Leu Lys Arg Gln Leu Glu 
225                 230                 235                 240 


His Asn Ala Tyr His Pro Ile Glu Trp Ala Ile Asn Ala Ala Thr Leu 
                245                 250                 255     


Ser Gln Phe Tyr Ile Asn Lys Leu Cys Phe Met Glu Ala Arg His Cys 
            260                 265                 270         


Leu Ser Ala Ala Asn Val Ile Phe Gly Gln Thr Gly Lys Ile Ser Ala 
        275                 280                 285             


Thr Glu Asp Thr Pro Glu Ala Glu Gly Glu Val Pro Glu Leu Tyr His 
    290                 295                 300                 


Gln Arg Lys Gly Glu Ile Ala Arg Cys Trp Ile Lys Tyr Cys Leu Thr 
305                 310                 315                 320 


Leu Met Gln Asn Ala Gln Leu Ser Met Gln Asp Asn Ile Gly Glu Leu 
                325                 330                 335     


Asp Leu Asp Lys Gln Ser Glu Leu Arg Ala Leu Arg Lys Lys Glu Leu 
            340                 345                 350         


Asp Glu Glu Glu Ser Ile Arg Lys Lys Ala Val Gln Phe Gly Thr Gly 
        355                 360                 365             


Glu Leu Cys Asp Ala Ile Ser Ala Val Glu Glu Lys Val Ser Tyr Leu 
    370                 375                 380                 


Arg Pro Leu Asp Phe Glu Glu Ala Arg Glu Leu Phe Leu Leu Gly Gln 
385                 390                 395                 400 


His Tyr Val Phe Glu Ala Lys Glu Phe Phe Gln Ile Asp Gly Tyr Val 
                405                 410                 415     


Thr Asp His Ile Glu Val Val Gln Asp His Ser Ala Leu Phe Lys Val 
            420                 425                 430         


Leu Ala Phe Phe Glu Thr Asp Met Glu Arg Arg Cys Lys Met His Lys 
        435                 440                 445             


Arg Arg Ile Ala Met Leu Glu Pro Leu Thr Val Asp Leu Asn Pro Gln 
    450                 455                 460                 


Tyr Tyr Leu Leu Val Asn Arg Gln Ile Gln Phe Glu Ile Ala His Ala 
465                 470                 475                 480 


Tyr Tyr Asp Met Met Asp Leu Lys Val Ala Ile Ala Asp Arg Leu Arg 
                485                 490                 495     


Asp Pro Asp Ser His Ile Val Lys Lys Ile Asn Asn Leu Asn Lys Ser 
            500                 505                 510         


Ala Leu Lys Tyr Tyr Gln Leu Phe Leu Asp Ser Leu Arg Asp Pro Asn 
        515                 520                 525             


Lys Val Phe Pro Glu His Ile Gly Glu Asp Val Leu Arg Pro Ala Met 
    530                 535                 540                 


Leu Ala Lys Phe Arg Val Ala Arg Leu Tyr Gly Lys Ile Ile Thr Ala 
545                 550                 555                 560 


Asp Pro Lys Lys Glu Leu Glu Asn Leu Ala Thr Ser Leu Glu His Tyr 
                565                 570                 575     


Lys Phe Ile Val Asp Tyr Cys Glu Lys His Pro Glu Ala Ala Gln Glu 
            580                 585                 590         


Ile Glu Val Glu Leu Glu Leu Ser Lys Glu Met Val Ser Leu Leu Pro 
        595                 600                 605             


Thr Lys Met Glu Arg Phe Arg Thr Lys Met Ala Leu Thr 
    610                 615                 620     


<210>  8
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Arg Glu Asn Gly Glu Ser Ser Ser Ser Trp Lys Lys Gln Ala 
1               5                   10                  15      


Glu Asp Ile Lys Lys Ile Phe Glu Phe Lys Glu Thr Leu Gly Thr Gly 
            20                  25                  30          


Ala Phe Ser Glu Val Val Leu Ala Glu Glu Lys Ala Thr Gly Lys Leu 
        35                  40                  45              


Phe Ala Val Lys Cys Ile Pro Lys Lys Ala Leu Lys Gly Lys Glu Ser 
    50                  55                  60                  


Ser Ile Glu Asn Glu Ile Ala Val Leu Arg Lys Ile Lys His Glu Asn 
65                  70                  75                  80  


Ile Val Ala Leu Glu Asp Ile Tyr Glu Ser Pro Asn His Leu Tyr Leu 
                85                  90                  95      


Val Met Gln Leu Val Ser Gly Gly Glu Leu Phe Asp Arg Ile Val Glu 
            100                 105                 110         


Lys Gly Phe Tyr Thr Glu Lys Asp Ala Ser Thr Leu Ile Arg Gln Val 
        115                 120                 125             


Leu Asp Ala Val Tyr Tyr Leu His Arg Met Gly Ile Val His Arg Asp 
    130                 135                 140                 


Leu Lys Pro Glu Asn Leu Leu Tyr Tyr Ser Gln Asp Glu Glu Ser Lys 
145                 150                 155                 160 


Ile Met Ile Ser Asp Phe Gly Leu Ser Lys Met Glu Gly Lys Gly Asp 
                165                 170                 175     


Val Met Ser Thr Ala Cys Gly Thr Pro Gly Tyr Val Ala Pro Glu Val 
            180                 185                 190         


Leu Ala Gln Lys Pro Tyr Ser Lys Ala Val Asp Cys Trp Ser Ile Gly 
        195                 200                 205             


Val Ile Ala Tyr Ile Leu Leu Cys Gly Tyr Pro Pro Phe Tyr Asp Glu 
    210                 215                 220                 


Asn Asp Ser Lys Leu Phe Glu Gln Ile Leu Lys Ala Glu Tyr Glu Phe 
225                 230                 235                 240 


Asp Ser Pro Tyr Trp Asp Asp Ile Ser Asp Ser Ala Lys Asp Phe Ile 
                245                 250                 255     


Arg Asn Leu Met Glu Lys Asp Pro Asn Lys Arg Tyr Thr Cys Glu Gln 
            260                 265                 270         


Ala Ala Arg His Pro Trp Ile Ala Gly Asp Thr Ala Leu Asn Lys Asn 
        275                 280                 285             


Ile His Glu Ser Val Ser Ala Gln Ile Arg Lys Asn Phe Ala Lys Ser 
    290                 295                 300                 


Lys Trp Arg Gln Ala Phe Asn Ala Thr Ala Val Val Arg His Met Arg 
305                 310                 315                 320 


Lys Leu His Leu Gly Ser Ser Leu Asp Ser Ser Asn Ala Ser Val Ser 
                325                 330                 335     


Ser Ser Leu Ser Leu Ala Ser Gln Lys Asp Cys Ala Tyr Val Ala Lys 
            340                 345                 350         


Pro Glu Ser Leu Ser 
        355         


<210>  9
<211>  882
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Ala Asp Lys Gly Pro Ala Ala Gly Pro Arg Ser Arg Ala Ala 
1               5                   10                  15      


Met Ala Gln Trp Arg Lys Lys Lys Gly Leu Arg Lys Arg Arg Gly Ala 
            20                  25                  30          


Ala Ser Gln Ala Arg Gly Ser Asp Ser Glu Asp Gly Glu Phe Glu Ile 
        35                  40                  45              


Gln Ala Glu Asp Asp Ala Arg Ala Arg Lys Leu Gly Pro Gly Arg Pro 
    50                  55                  60                  


Leu Pro Thr Phe Pro Thr Ser Glu Cys Thr Ser Asp Val Glu Pro Asp 
65                  70                  75                  80  


Thr Arg Glu Met Val Arg Ala Gln Asn Lys Lys Lys Lys Lys Ser Gly 
                85                  90                  95      


Gly Phe Gln Ser Met Gly Leu Ser Tyr Pro Val Phe Lys Gly Ile Met 
            100                 105                 110         


Lys Lys Gly Tyr Lys Val Pro Thr Pro Ile Gln Arg Lys Thr Ile Pro 
        115                 120                 125             


Val Ile Leu Asp Gly Lys Asp Val Val Ala Met Ala Arg Thr Gly Ser 
    130                 135                 140                 


Gly Lys Thr Ala Cys Phe Leu Leu Pro Met Phe Glu Arg Leu Lys Thr 
145                 150                 155                 160 


His Ser Ala Gln Thr Gly Ala Arg Ala Leu Ile Leu Ser Pro Thr Arg 
                165                 170                 175     


Glu Leu Ala Leu Gln Thr Leu Lys Phe Thr Lys Glu Leu Gly Lys Phe 
            180                 185                 190         


Thr Gly Leu Lys Thr Ala Leu Ile Leu Gly Gly Asp Arg Met Glu Asp 
        195                 200                 205             


Gln Phe Ala Ala Leu His Glu Asn Pro Asp Ile Ile Ile Ala Thr Pro 
    210                 215                 220                 


Gly Arg Leu Val His Val Ala Val Glu Met Ser Leu Lys Leu Gln Ser 
225                 230                 235                 240 


Val Glu Tyr Val Val Phe Asp Glu Ala Asp Arg Leu Phe Glu Met Gly 
                245                 250                 255     


Phe Ala Glu Gln Leu Gln Glu Ile Ile Ala Arg Leu Pro Gly Gly His 
            260                 265                 270         


Gln Thr Val Leu Phe Ser Ala Thr Leu Pro Lys Leu Leu Val Glu Phe 
        275                 280                 285             


Ala Arg Ala Gly Leu Thr Glu Pro Val Leu Ile Arg Leu Asp Val Asp 
    290                 295                 300                 


Thr Lys Leu Asn Glu Gln Leu Lys Thr Ser Phe Phe Leu Val Arg Glu 
305                 310                 315                 320 


Asp Thr Lys Ala Ala Val Leu Leu His Leu Leu His Asn Val Val Arg 
                325                 330                 335     


Pro Gln Asp Gln Thr Val Val Phe Val Ala Thr Lys His His Ala Glu 
            340                 345                 350         


Tyr Leu Thr Glu Leu Leu Thr Thr Gln Arg Val Ser Cys Ala His Ile 
        355                 360                 365             


Tyr Ser Ala Leu Asp Pro Thr Ala Arg Lys Ile Asn Leu Ala Lys Phe 
    370                 375                 380                 


Thr Leu Gly Lys Cys Ser Thr Leu Ile Val Thr Asp Leu Ala Ala Arg 
385                 390                 395                 400 


Gly Leu Asp Ile Pro Leu Leu Asp Asn Val Ile Asn Tyr Ser Phe Pro 
                405                 410                 415     


Ala Lys Gly Lys Leu Phe Leu His Arg Val Gly Arg Val Ala Arg Ala 
            420                 425                 430         


Gly Arg Ser Gly Thr Ala Tyr Ser Leu Val Ala Pro Asp Glu Ile Pro 
        435                 440                 445             


Tyr Leu Leu Asp Leu His Leu Phe Leu Gly Arg Ser Leu Thr Leu Ala 
    450                 455                 460                 


Arg Pro Leu Lys Glu Pro Ser Gly Val Ala Gly Val Asp Gly Met Leu 
465                 470                 475                 480 


Gly Arg Val Pro Gln Ser Val Val Asp Glu Glu Asp Ser Gly Leu Gln 
                485                 490                 495     


Ser Thr Leu Glu Ala Ser Leu Glu Leu Arg Gly Leu Ala Arg Val Ala 
            500                 505                 510         


Asp Asn Ala Gln Gln Gln Tyr Val Arg Ser Arg Pro Ala Pro Ser Pro 
        515                 520                 525             


Glu Ser Ile Lys Arg Ala Lys Glu Met Asp Leu Val Gly Leu Gly Leu 
    530                 535                 540                 


His Pro Leu Phe Ser Ser Arg Phe Glu Glu Glu Glu Leu Gln Arg Leu 
545                 550                 555                 560 


Arg Leu Val Asp Ser Ile Lys Asn Tyr Arg Ser Arg Ala Thr Ile Phe 
                565                 570                 575     


Glu Ile Asn Ala Ser Ser Arg Asp Leu Cys Ser Gln Val Met Arg Ala 
            580                 585                 590         


Lys Arg Gln Lys Asp Arg Lys Ala Ile Ala Arg Phe Gln Gln Gly Gln 
        595                 600                 605             


Gln Gly Arg Gln Glu Gln Gln Glu Gly Pro Val Gly Pro Ala Pro Ser 
    610                 615                 620                 


Arg Pro Ala Leu Gln Glu Lys Gln Pro Glu Lys Glu Glu Glu Glu Glu 
625                 630                 635                 640 


Ala Gly Glu Ser Val Glu Asp Ile Phe Ser Glu Val Val Gly Arg Lys 
                645                 650                 655     


Arg Gln Arg Ser Gly Pro Asn Arg Gly Ala Lys Arg Arg Arg Glu Glu 
            660                 665                 670         


Ala Arg Gln Arg Asp Gln Glu Phe Tyr Ile Pro Tyr Arg Pro Lys Asp 
        675                 680                 685             


Phe Asp Ser Glu Arg Gly Leu Ser Ile Ser Gly Glu Gly Gly Ala Phe 
    690                 695                 700                 


Glu Gln Gln Ala Ala Gly Ala Val Leu Asp Leu Met Gly Asp Glu Ala 
705                 710                 715                 720 


Gln Asn Leu Thr Arg Gly Arg Gln Gln Leu Lys Trp Asp Arg Lys Lys 
                725                 730                 735     


Lys Arg Phe Val Gly Gln Ser Gly Gln Glu Asp Lys Lys Lys Ile Lys 
            740                 745                 750         


Thr Glu Ser Gly Arg Tyr Ile Ser Ser Ser Tyr Lys Arg Asp Leu Tyr 
        755                 760                 765             


Gln Lys Trp Lys Gln Lys Gln Lys Ile Asp Asp Arg Asp Ser Asp Glu 
    770                 775                 780                 


Glu Gly Ala Ser Asp Arg Arg Gly Pro Glu Arg Arg Gly Gly Lys Arg 
785                 790                 795                 800 


Asp Arg Gly Gln Ala Gly Ala Ser Arg Pro His Ala Pro Gly Thr Pro 
                805                 810                 815     


Ala Gly Arg Val Arg Pro Glu Leu Lys Thr Lys Gln Gln Ile Leu Lys 
            820                 825                 830         


Gln Arg Arg Arg Ala Gln Lys Leu His Phe Leu Gln Arg Gly Gly Leu 
        835                 840                 845             


Lys Gln Leu Ser Ala Arg Asn Arg Arg Arg Val Gln Glu Leu Gln Gln 
    850                 855                 860                 


Gly Ala Phe Gly Arg Gly Ala Arg Ser Lys Lys Gly Lys Met Arg Lys 
865                 870                 875                 880 


Arg Met 
        


<210>  10
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Ala Gly Met Tyr Leu Glu His Tyr Leu Asp Ser Ile Glu Asn 
1               5                   10                  15      


Leu Pro Phe Glu Leu Gln Arg Asn Phe Gln Leu Met Arg Asp Leu Asp 
            20                  25                  30          


Gln Arg Thr Glu Asp Leu Lys Ala Glu Ile Asp Lys Leu Ala Thr Glu 
        35                  40                  45              


Tyr Met Ser Ser Ala Arg Ser Leu Ser Ser Glu Glu Lys Leu Ala Leu 
    50                  55                  60                  


Leu Lys Gln Ile Gln Glu Ala Tyr Gly Lys Cys Lys Glu Phe Gly Asp 
65                  70                  75                  80  


Asp Lys Val Gln Leu Ala Met Gln Thr Tyr Glu Met Val Asp Lys His 
                85                  90                  95      


Ile Arg Arg Leu Asp Thr Asp Leu Ala Arg Phe Glu Ala Asp Leu Lys 
            100                 105                 110         


Glu Lys Gln Ile Glu Ser Ser Asp Tyr Asp Ser Ser Ser Ser Lys Gly 
        115                 120                 125             


Lys Lys Lys Gly Arg Thr Gln Lys Glu Lys Lys Ala Ala Arg Ala Arg 
    130                 135                 140                 


Ser Lys Gly Lys Asn Ser Asp Glu Glu Ala Pro Lys Thr Ala Gln Lys 
145                 150                 155                 160 


Lys Leu Lys Leu Val Arg Thr Ser Pro Glu Tyr Gly Met Pro Ser Val 
                165                 170                 175     


Thr Phe Gly Ser Val His Pro Ser Asp Val Leu Asp Met Pro Val Asp 
            180                 185                 190         


Pro Asn Glu Pro Thr Tyr Cys Leu Cys His Gln Val Ser Tyr Gly Glu 
        195                 200                 205             


Met Ile Gly Cys Asp Asn Pro Asp Cys Ser Ile Glu Trp Phe His Phe 
    210                 215                 220                 


Ala Cys Val Gly Leu Thr Thr Lys Pro Arg Gly Lys Trp Phe Cys Pro 
225                 230                 235                 240 


Arg Cys Ser Gln Glu Arg Lys Lys Lys 
                245                 


<210>  11
<211>  156
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Gln Ile Phe Val Lys Thr Leu Met Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Leu Ser Asp Thr Ile Asp Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 
    50                  55                  60                  


Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly Ala Lys Lys Arg 
65                  70                  75                  80  


Lys Lys Lys Ser Tyr Thr Thr Pro Arg Lys Asn Lys His Lys Arg Lys 
                85                  90                  95      


Lys Val Lys Leu Ala Leu Leu Lys Tyr Tyr Lys Val Asp Glu Asn Gly 
            100                 105                 110         


Lys Ile Ser Cys Leu His Arg Glu Cys Pro Ser Asp Glu Cys Gly Ala 
        115                 120                 125             


Gly Val Phe Met Ala Ser His Phe Asp Arg His Tyr Cys Gly Lys Cys 
    130                 135                 140                 


Cys Leu Thr Tyr Cys Phe Asn Lys Pro Glu Asp Lys 
145                 150                 155     


<210>  12
<211>  859
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Lys Leu Lys Asp Thr Lys Ser Arg Pro Lys Gln Ser Ser Cys Gly 
1               5                   10                  15      


Lys Phe Gln Thr Lys Gly Ile Lys Val Val Gly Lys Trp Lys Glu Val 
            20                  25                  30          


Lys Ile Asp Pro Asn Met Phe Ala Asp Gly Gln Met Asp Asp Leu Val 
        35                  40                  45              


Cys Phe Glu Glu Leu Thr Asp Tyr Gln Leu Val Ser Pro Ala Lys Asn 
    50                  55                  60                  


Pro Ser Ser Leu Phe Ser Lys Glu Ala Pro Lys Arg Lys Ala Gln Ala 
65                  70                  75                  80  


Val Ser Glu Glu Glu Glu Glu Glu Glu Gly Lys Ser Ser Ser Pro Lys 
                85                  90                  95      


Lys Lys Ile Lys Leu Lys Lys Ser Lys Asn Val Ala Thr Glu Gly Thr 
            100                 105                 110         


Ser Thr Gln Lys Glu Phe Glu Val Lys Asp Pro Glu Leu Glu Ala Gln 
        115                 120                 125             


Gly Asp Asp Met Val Cys Asp Asp Pro Glu Ala Gly Glu Met Thr Ser 
    130                 135                 140                 


Glu Asn Leu Val Gln Thr Ala Pro Lys Lys Lys Lys Asn Lys Gly Lys 
145                 150                 155                 160 


Lys Gly Leu Glu Pro Ser Gln Ser Thr Ala Ala Lys Val Pro Lys Lys 
                165                 170                 175     


Ala Lys Thr Trp Ile Pro Glu Val His Asp Gln Lys Ala Asp Val Ser 
            180                 185                 190         


Ala Trp Lys Asp Leu Phe Val Pro Arg Pro Val Leu Arg Ala Leu Ser 
        195                 200                 205             


Phe Leu Gly Phe Ser Ala Pro Thr Pro Ile Gln Ala Leu Thr Leu Ala 
    210                 215                 220                 


Pro Ala Ile Arg Asp Lys Leu Asp Ile Leu Gly Ala Ala Glu Thr Gly 
225                 230                 235                 240 


Ser Gly Lys Thr Leu Ala Phe Ala Ile Pro Met Ile His Ala Val Leu 
                245                 250                 255     


Gln Trp Gln Lys Arg Asn Ala Ala Pro Pro Pro Ser Asn Thr Glu Ala 
            260                 265                 270         


Pro Pro Gly Glu Thr Arg Thr Glu Ala Gly Ala Glu Thr Arg Ser Pro 
        275                 280                 285             


Gly Lys Ala Glu Ala Glu Ser Asp Ala Leu Pro Asp Asp Thr Val Ile 
    290                 295                 300                 


Glu Ser Glu Ala Leu Pro Ser Asp Ile Ala Ala Glu Ala Arg Ala Lys 
305                 310                 315                 320 


Thr Gly Gly Thr Val Ser Asp Gln Ala Leu Leu Phe Gly Asp Asp Asp 
                325                 330                 335     


Ala Gly Glu Gly Pro Ser Ser Leu Ile Arg Glu Lys Pro Val Pro Lys 
            340                 345                 350         


Gln Asn Glu Asn Glu Glu Glu Asn Leu Asp Lys Glu Gln Thr Gly Asn 
        355                 360                 365             


Leu Lys Gln Glu Leu Asp Asp Lys Ser Ala Thr Cys Lys Ala Tyr Pro 
    370                 375                 380                 


Lys Arg Pro Leu Leu Gly Leu Val Leu Thr Pro Thr Arg Glu Leu Ala 
385                 390                 395                 400 


Val Gln Val Lys Gln His Ile Asp Ala Val Ala Arg Phe Thr Gly Ile 
                405                 410                 415     


Lys Thr Ala Ile Leu Val Gly Gly Met Ser Thr Gln Lys Gln Gln Arg 
            420                 425                 430         


Met Leu Asn Arg Arg Pro Glu Ile Val Val Ala Thr Pro Gly Arg Leu 
        435                 440                 445             


Trp Glu Leu Ile Lys Glu Lys His Tyr His Leu Arg Asn Leu Arg Gln 
    450                 455                 460                 


Leu Arg Cys Leu Val Val Asp Glu Ala Asp Arg Met Val Glu Lys Gly 
465                 470                 475                 480 


His Phe Ala Glu Leu Ser Gln Leu Leu Glu Met Leu Asn Asp Ser Gln 
                485                 490                 495     


Tyr Asn Pro Lys Arg Gln Thr Leu Val Phe Ser Ala Thr Leu Thr Leu 
            500                 505                 510         


Val His Gln Ala Pro Ala Arg Ile Leu His Lys Lys His Thr Lys Lys 
        515                 520                 525             


Met Asp Lys Thr Ala Lys Leu Asp Leu Leu Met Gln Lys Ile Gly Met 
    530                 535                 540                 


Arg Gly Lys Pro Lys Val Ile Asp Leu Thr Arg Asn Glu Ala Thr Val 
545                 550                 555                 560 


Glu Thr Leu Thr Glu Thr Lys Ile His Cys Glu Thr Asp Glu Lys Asp 
                565                 570                 575     


Phe Tyr Leu Tyr Tyr Phe Leu Met Gln Tyr Pro Gly Arg Ser Leu Val 
            580                 585                 590         


Phe Ala Asn Ser Ile Ser Cys Ile Lys Arg Leu Ser Gly Leu Leu Lys 
        595                 600                 605             


Val Leu Asp Ile Met Pro Leu Thr Leu His Ala Cys Met His Gln Lys 
    610                 615                 620                 


Gln Arg Leu Arg Asn Leu Glu Gln Phe Ala Arg Leu Glu Asp Cys Val 
625                 630                 635                 640 


Leu Leu Ala Thr Asp Val Ala Ala Arg Gly Leu Asp Ile Pro Lys Val 
                645                 650                 655     


Gln His Val Ile His Tyr Gln Val Pro Arg Thr Ser Glu Ile Tyr Val 
            660                 665                 670         


His Arg Ser Gly Arg Thr Ala Arg Ala Thr Asn Glu Gly Leu Ser Leu 
        675                 680                 685             


Met Leu Ile Gly Pro Glu Asp Val Ile Asn Phe Lys Lys Ile Tyr Lys 
    690                 695                 700                 


Thr Leu Lys Lys Asp Glu Asp Ile Pro Leu Phe Pro Val Gln Thr Lys 
705                 710                 715                 720 


Tyr Met Asp Val Val Lys Glu Arg Ile Arg Leu Ala Arg Gln Ile Glu 
                725                 730                 735     


Lys Ser Glu Tyr Arg Asn Phe Gln Ala Cys Leu His Asn Ser Trp Ile 
            740                 745                 750         


Glu Gln Ala Ala Ala Ala Leu Glu Ile Glu Leu Glu Glu Asp Met Tyr 
        755                 760                 765             


Lys Gly Gly Lys Ala Asp Gln Gln Glu Glu Arg Arg Arg Gln Lys Gln 
    770                 775                 780                 


Met Lys Val Leu Lys Lys Glu Leu Arg His Leu Leu Ser Gln Pro Leu 
785                 790                 795                 800 


Phe Thr Glu Ser Gln Lys Thr Lys Tyr Pro Thr Gln Ser Gly Lys Pro 
                805                 810                 815     


Pro Leu Leu Val Ser Ala Pro Ser Lys Ser Glu Ser Ala Leu Ser Cys 
            820                 825                 830         


Leu Ser Lys Gln Lys Lys Lys Lys Thr Lys Lys Pro Lys Glu Pro Gln 
        835                 840                 845             


Pro Glu Gln Pro Gln Pro Ser Thr Ser Ala Asn 
    850                 855                 


<210>  13
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Ala Gly Pro Glu Pro Pro Glu Trp Glu Pro Arg Trp Arg Lys 
1               5                   10                  15      


Ala Leu Arg Gly Lys Glu Asn Lys Gly Ser Val Glu Ile Met Arg Lys 
            20                  25                  30          


Asp Leu Asn Asp Ala Arg Asp Leu His Gly Gln Ala Glu Ser Ala Ala 
        35                  40                  45              


Ala Val Trp Lys Gly His Val Met Asp Arg Arg Lys Lys Ala Leu Thr 
    50                  55                  60                  


Asp Tyr Lys Lys Leu Arg Ala Phe Phe Val Glu Glu Glu Glu His Phe 
65                  70                  75                  80  


Leu Gln Glu Ala Glu Lys Glu Glu Gly Leu Pro Glu Asp Glu Leu Ala 
                85                  90                  95      


Asp Pro Thr Glu Arg Phe Arg Ser Leu Leu Gln Ala Val Ser Glu Leu 
            100                 105                 110         


Glu Lys Lys His Arg Asn Leu Gly Leu Ser Met Leu Leu Gln 
        115                 120                 125     


<210>  14
<211>  710
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ser Val Pro Ser Ser Leu Ser Gln Ser Ala Ile Asn Ala Asn Ser 
1               5                   10                  15      


His Gly Gly Pro Ala Leu Ser Leu Pro Leu Pro Leu His Ala Ala His 
            20                  25                  30          


Asn Gln Leu Leu Asn Ala Lys Leu Gln Ala Thr Ala Val Gly Pro Lys 
        35                  40                  45              


Asp Leu Arg Ser Ala Met Gly Glu Gly Gly Gly Pro Glu Pro Gly Pro 
    50                  55                  60                  


Ala Asn Ala Lys Trp Leu Lys Glu Gly Gln Asn Gln Leu Arg Arg Ala 
65                  70                  75                  80  


Ala Thr Ala His Arg Asp Gln Asn Arg Asn Val Thr Leu Thr Leu Ala 
                85                  90                  95      


Glu Glu Ala Ser Gln Glu Pro Glu Met Ala Pro Leu Gly Pro Lys Gly 
            100                 105                 110         


Leu Ile His Leu Tyr Ser Glu Leu Glu Leu Ser Ala His Asn Ala Ala 
        115                 120                 125             


Asn Arg Gly Leu Arg Gly Pro Gly Leu Ile Ile Ser Thr Gln Glu Gln 
    130                 135                 140                 


Gly Pro Asp Glu Gly Glu Glu Lys Ala Ala Gly Glu Ala Glu Glu Glu 
145                 150                 155                 160 


Glu Glu Asp Asp Asp Asp Glu Glu Glu Glu Glu Asp Leu Ser Ser Pro 
                165                 170                 175     


Pro Gly Leu Pro Glu Pro Leu Glu Ser Val Glu Ala Pro Pro Arg Pro 
            180                 185                 190         


Gln Ala Leu Thr Asp Gly Pro Arg Glu His Ser Lys Ser Ala Ser Leu 
        195                 200                 205             


Leu Phe Gly Met Arg Asn Ser Ala Ala Ser Asp Glu Asp Ser Ser Trp 
    210                 215                 220                 


Ala Thr Leu Ser Gln Gly Ser Pro Ser Tyr Gly Ser Pro Glu Asp Thr 
225                 230                 235                 240 


Asp Ser Phe Trp Asn Pro Asn Ala Phe Glu Thr Asp Ser Asp Leu Pro 
                245                 250                 255     


Ala Gly Trp Met Arg Val Gln Asp Thr Ser Gly Thr Tyr Tyr Trp His 
            260                 265                 270         


Ile Pro Thr Gly Thr Thr Gln Trp Glu Pro Pro Gly Arg Ala Ser Pro 
        275                 280                 285             


Ser Gln Gly Ser Ser Pro Gln Glu Glu Ser Gln Leu Thr Trp Thr Gly 
    290                 295                 300                 


Phe Ala His Gly Glu Gly Phe Glu Asp Gly Glu Phe Trp Lys Asp Glu 
305                 310                 315                 320 


Pro Ser Asp Glu Ala Pro Met Glu Leu Gly Leu Lys Glu Pro Glu Glu 
                325                 330                 335     


Gly Thr Leu Thr Phe Pro Ala Gln Ser Leu Ser Pro Glu Pro Leu Pro 
            340                 345                 350         


Gln Glu Glu Glu Lys Leu Pro Pro Arg Asn Thr Asn Pro Gly Ile Lys 
        355                 360                 365             


Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu Met Thr Glu Glu Glu 
    370                 375                 380                 


Leu Ala Pro Gly Arg Ser Ser Val Ala Val Asn Asn Cys Ile Arg Gln 
385                 390                 395                 400 


Leu Ser Tyr His Lys Asn Asn Leu His Asp Pro Met Ser Gly Gly Trp 
                405                 410                 415     


Gly Glu Gly Lys Asp Leu Leu Leu Gln Leu Glu Asp Glu Thr Leu Lys 
            420                 425                 430         


Leu Val Glu Pro Gln Ser Gln Ala Leu Leu His Ala Gln Pro Ile Ile 
        435                 440                 445             


Ser Ile Arg Val Trp Gly Val Gly Arg Asp Ser Gly Arg Glu Arg Asp 
    450                 455                 460                 


Phe Ala Tyr Val Ala Arg Asp Lys Leu Thr Gln Met Leu Lys Cys His 
465                 470                 475                 480 


Val Phe Arg Cys Glu Ala Pro Ala Lys Asn Ile Ala Thr Ser Leu His 
                485                 490                 495     


Glu Ile Cys Ser Lys Ile Met Ala Glu Arg Arg Asn Ala Arg Cys Leu 
            500                 505                 510         


Val Asn Gly Leu Ser Leu Asp His Ser Lys Leu Val Asp Val Pro Phe 
        515                 520                 525             


Gln Val Glu Phe Pro Ala Pro Lys Asn Glu Leu Val Gln Lys Phe Gln 
    530                 535                 540                 


Val Tyr Tyr Leu Gly Asn Val Pro Val Ala Lys Pro Val Gly Val Asp 
545                 550                 555                 560 


Val Ile Asn Gly Ala Leu Glu Ser Val Leu Ser Ser Ser Ser Arg Glu 
                565                 570                 575     


Gln Trp Thr Pro Ser His Val Ser Val Ala Pro Ala Thr Leu Thr Ile 
            580                 585                 590         


Leu His Gln Gln Thr Glu Ala Val Leu Gly Glu Cys Arg Val Arg Phe 
        595                 600                 605             


Leu Ser Phe Leu Ala Val Gly Arg Asp Val His Thr Phe Ala Phe Ile 
    610                 615                 620                 


Met Ala Ala Gly Pro Ala Ser Phe Cys Cys His Met Phe Trp Cys Glu 
625                 630                 635                 640 


Pro Asn Ala Ala Ser Leu Ser Glu Ala Val Gln Ala Ala Cys Met Leu 
                645                 650                 655     


Arg Tyr Gln Lys Cys Leu Asp Ala Arg Ser Gln Ala Ser Thr Ser Cys 
            660                 665                 670         


Leu Pro Ala Pro Pro Ala Glu Ser Val Ala Arg Arg Val Gly Trp Thr 
        675                 680                 685             


Val Arg Arg Gly Val Gln Ser Leu Trp Gly Ser Leu Lys Pro Lys Arg 
    690                 695                 700                 


Leu Gly Ala His Thr Pro 
705                 710 


<210>  15
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ala Ser Thr Ser Arg Leu Asp Ala Leu Pro Arg Val Thr Cys Pro 
1               5                   10                  15      


Asn His Pro Asp Ala Ile Leu Val Glu Asp Tyr Arg Ala Gly Asp Met 
            20                  25                  30          


Ile Cys Pro Glu Cys Gly Leu Val Val Gly Asp Arg Val Ile Asp Val 
        35                  40                  45              


Gly Ser Glu Trp Arg Thr Phe Ser Asn Asp Lys Ala Thr Lys Asp Pro 
    50                  55                  60                  


Ser Arg Val Gly Asp Ser Gln Asn Pro Leu Leu Ser Asp Gly Asp Leu 
65                  70                  75                  80  


Ser Thr Met Ile Gly Lys Gly Thr Gly Ala Ala Ser Phe Asp Glu Phe 
                85                  90                  95      


Gly Asn Ser Lys Tyr Gln Asn Arg Arg Thr Met Ser Ser Ser Asp Arg 
            100                 105                 110         


Ala Met Met Asn Ala Phe Lys Glu Ile Thr Thr Met Ala Asp Arg Ile 
        115                 120                 125             


Asn Leu Pro Arg Asn Ile Val Asp Arg Thr Asn Asn Leu Phe Lys Gln 
    130                 135                 140                 


Val Tyr Glu Gln Lys Ser Leu Lys Gly Arg Ala Asn Asp Ala Ile Ala 
145                 150                 155                 160 


Ser Ala Cys Leu Tyr Ile Ala Cys Arg Gln Glu Gly Val Pro Arg Thr 
                165                 170                 175     


Phe Lys Glu Ile Cys Ala Val Ser Arg Ile Ser Lys Lys Glu Ile Gly 
            180                 185                 190         


Arg Cys Phe Lys Leu Ile Leu Lys Ala Leu Glu Thr Ser Val Asp Leu 
        195                 200                 205             


Ile Thr Thr Gly Asp Phe Met Ser Arg Phe Cys Ser Asn Leu Cys Leu 
    210                 215                 220                 


Pro Lys Gln Val Gln Met Ala Ala Thr His Ile Ala Arg Lys Ala Val 
225                 230                 235                 240 


Glu Leu Asp Leu Val Pro Gly Arg Ser Pro Ile Ser Val Ala Ala Ala 
                245                 250                 255     


Ala Ile Tyr Met Ala Ser Gln Ala Ser Ala Glu Lys Arg Thr Gln Lys 
            260                 265                 270         


Glu Ile Gly Asp Ile Ala Gly Val Ala Asp Val Thr Ile Arg Gln Ser 
        275                 280                 285             


Tyr Arg Leu Ile Tyr Pro Arg Ala Pro Asp Leu Phe Pro Thr Asp Phe 
    290                 295                 300                 


Lys Phe Asp Thr Pro Val Asp Lys Leu Pro Gln Leu 
305                 310                 315     


<210>  16
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Lys Ile Lys Ala Arg Asp Leu Arg Gly Lys Lys Lys Glu Glu 
1               5                   10                  15      


Leu Leu Lys Gln Leu Asp Asp Leu Lys Val Glu Leu Ser Gln Leu Arg 
            20                  25                  30          


Val Ala Lys Val Thr Gly Gly Ala Ala Ser Lys Leu Ser Lys Ile Arg 
        35                  40                  45              


Val Val Arg Lys Ser Ile Ala Arg Val Leu Thr Val Ile Asn Gln Thr 
    50                  55                  60                  


Gln Lys Glu Asn Leu Arg Lys Phe Tyr Lys Gly Lys Lys Tyr Lys Pro 
65                  70                  75                  80  


Leu Asp Leu Arg Pro Lys Lys Thr Arg Ala Met Arg Arg Arg Leu Asn 
                85                  90                  95      


Lys His Glu Glu Asn Leu Lys Thr Lys Lys Gln Gln Arg Lys Glu Arg 
            100                 105                 110         


Leu Tyr Pro Leu Arg Lys Tyr Ala Val Lys Ala 
        115                 120             


<210>  17
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ala Ala Leu Thr Arg Asp Pro Gln Phe Gln Lys Leu Gln Gln Trp 
1               5                   10                  15      


Tyr Arg Glu His Arg Ser Glu Leu Asn Leu Arg Arg Leu Phe Asp Ala 
            20                  25                  30          


Asn Lys Asp Arg Phe Asn His Phe Ser Leu Thr Leu Asn Thr Asn His 
        35                  40                  45              


Gly His Ile Leu Val Asp Tyr Ser Lys Asn Leu Val Thr Glu Asp Val 
    50                  55                  60                  


Met Arg Met Leu Val Asp Leu Ala Lys Ser Arg Gly Val Glu Ala Ala 
65                  70                  75                  80  


Arg Glu Arg Met Phe Asn Gly Glu Lys Ile Asn Tyr Thr Glu Gly Arg 
                85                  90                  95      


Ala Val Leu His Val Ala Leu Arg Asn Arg Ser Asn Thr Pro Ile Leu 
            100                 105                 110         


Val Asp Gly Lys Asp Val Met Pro Glu Val Asn Lys Val Leu Asp Lys 
        115                 120                 125             


Met Lys Ser Phe Cys Gln Arg Val Arg Ser Gly Asp Trp Lys Gly Tyr 
    130                 135                 140                 


Thr Gly Lys Thr Ile Thr Asp Val Ile Asn Ile Gly Ile Gly Gly Ser 
145                 150                 155                 160 


Asp Leu Gly Pro Leu Met Val Thr Glu Ala Leu Lys Pro Tyr Ser Ser 
                165                 170                 175     


Gly Gly Pro Arg Val Trp Tyr Val Ser Asn Ile Asp Gly Thr His Ile 
            180                 185                 190         


Ala Lys Thr Leu Ala Gln Leu Asn Pro Glu Ser Ser Leu Phe Ile Ile 
        195                 200                 205             


Ala Ser Lys Thr Phe Thr Thr Gln Glu Thr Ile Thr Asn Ala Glu Thr 
    210                 215                 220                 


Ala Lys Glu Trp Phe Leu Gln Ala Ala Lys Asp Pro Ser Ala Val Ala 
225                 230                 235                 240 


Lys His Phe Val Ala Leu Ser Thr Asn Thr Thr Lys Val Lys Glu Phe 
                245                 250                 255     


Gly Ile Asp Pro Gln Asn Met Phe Glu Phe Trp Asp Trp Val Gly Gly 
            260                 265                 270         


Arg Tyr Ser Leu Trp Ser Ala Ile Gly Leu Ser Ile Ala Leu His Val 
        275                 280                 285             


Gly Phe Asp Asn Phe Glu Gln Leu Leu Ser Gly Ala His Trp Met Asp 
    290                 295                 300                 


Gln His Phe Arg Thr Thr Pro Leu Glu Lys Asn Ala Pro Val Leu Leu 
305                 310                 315                 320 


Ala Leu Leu Gly Ile Trp Tyr Ile Asn Cys Phe Gly Cys Glu Thr His 
                325                 330                 335     


Ala Met Leu Pro Tyr Asp Gln Tyr Leu His Arg Phe Ala Ala Tyr Phe 
            340                 345                 350         


Gln Gln Gly Asp Met Glu Ser Asn Gly Lys Tyr Ile Thr Lys Ser Gly 
        355                 360                 365             


Thr Arg Val Asp His Gln Thr Gly Pro Ile Val Trp Gly Glu Pro Gly 
    370                 375                 380                 


Thr Asn Gly Gln His Ala Phe Tyr Gln Leu Ile His Gln Gly Thr Lys 
385                 390                 395                 400 


Met Ile Pro Cys Asp Phe Leu Ile Pro Val Gln Thr Gln His Pro Ile 
                405                 410                 415     


Arg Lys Gly Leu His His Lys Ile Leu Leu Ala Asn Phe Leu Ala Gln 
            420                 425                 430         


Thr Glu Ala Leu Met Arg Gly Lys Ser Thr Glu Glu Ala Arg Lys Glu 
        435                 440                 445             


Leu Gln Ala Ala Gly Lys Ser Pro Glu Asp Leu Glu Arg Leu Leu Pro 
    450                 455                 460                 


His Lys Val Phe Glu Gly Asn Arg Pro Thr Asn Ser Ile Val Phe Thr 
465                 470                 475                 480 


Lys Leu Thr Pro Phe Met Leu Gly Ala Leu Val Ala Met Tyr Glu His 
                485                 490                 495     


Lys Ile Phe Val Gln Gly Ile Ile Trp Asp Ile Asn Ser Phe Asp Gln 
            500                 505                 510         


Trp Gly Val Glu Leu Gly Lys Gln Leu Ala Lys Lys Ile Glu Pro Glu 
        515                 520                 525             


Leu Asp Gly Ser Ala Gln Val Thr Ser His Asp Ala Ser Thr Asn Gly 
    530                 535                 540                 


Leu Ile Asn Phe Ile Lys Gln Gln Arg Glu Ala Arg Val Gln 
545                 550                 555             


<210>  18
<211>  599
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Gly Pro Lys Arg Arg Gln Leu Thr Phe Arg Glu Lys Ser Arg Ile 
1               5                   10                  15      


Ile Gln Glu Val Glu Glu Asn Pro Asp Leu Arg Lys Gly Glu Ile Ala 
            20                  25                  30          


Arg Arg Phe Asn Ile Pro Pro Ser Thr Leu Ser Thr Ile Leu Lys Asn 
        35                  40                  45              


Lys Arg Ala Ile Leu Ala Ser Glu Arg Lys Tyr Gly Val Ala Ser Thr 
    50                  55                  60                  


Cys Arg Lys Thr Asn Lys Leu Ser Pro Tyr Asp Lys Leu Glu Gly Leu 
65                  70                  75                  80  


Leu Ile Ala Trp Phe Gln Gln Ile Arg Ala Ala Gly Leu Pro Val Lys 
                85                  90                  95      


Gly Ile Ile Leu Lys Glu Lys Ala Leu Arg Ile Ala Glu Glu Leu Gly 
            100                 105                 110         


Met Asp Asp Phe Thr Ala Ser Asn Gly Trp Leu Asp Arg Phe Arg Arg 
        115                 120                 125             


Arg His Gly Val Val Ser Cys Ser Gly Val Ala Arg Ala Arg Ala Arg 
    130                 135                 140                 


Asn Ala Ala Pro Arg Thr Pro Ala Ala Pro Ala Ser Pro Ala Ala Val 
145                 150                 155                 160 


Pro Ser Glu Gly Ser Gly Gly Ser Thr Thr Gly Trp Arg Ala Arg Glu 
                165                 170                 175     


Glu Gln Pro Pro Ser Val Ala Glu Gly Tyr Ala Ser Gln Asp Val Phe 
            180                 185                 190         


Ser Ala Thr Glu Thr Ser Leu Trp Tyr Asp Phe Leu Pro Asp Gln Ala 
        195                 200                 205             


Ala Gly Leu Cys Gly Gly Asp Gly Arg Pro Arg Gln Ala Thr Gln Arg 
    210                 215                 220                 


Leu Ser Val Leu Leu Cys Ala Asn Ala Asp Gly Ser Glu Lys Leu Pro 
225                 230                 235                 240 


Pro Leu Val Ala Gly Lys Ser Ala Lys Pro Arg Ala Gly Gln Ala Gly 
                245                 250                 255     


Leu Pro Cys Asp Tyr Thr Ala Asn Ser Lys Gly Gly Val Thr Thr Gln 
            260                 265                 270         


Ala Leu Ala Lys Tyr Leu Lys Ala Leu Asp Thr Arg Met Ala Ala Glu 
        275                 280                 285             


Ser Arg Arg Val Leu Leu Leu Ala Gly Arg Leu Ala Ala Gln Ser Leu 
    290                 295                 300                 


Asp Thr Ser Gly Leu Arg His Val Gln Leu Ala Phe Phe Pro Pro Gly 
305                 310                 315                 320 


Thr Val His Pro Leu Glu Arg Gly Val Val Gln Gln Val Lys Gly His 
                325                 330                 335     


Tyr Arg Gln Ala Met Leu Leu Lys Ala Met Ala Ala Leu Glu Gly Gln 
            340                 345                 350         


Asp Pro Ser Gly Leu Gln Leu Gly Leu Thr Glu Ala Leu His Phe Val 
        355                 360                 365             


Ala Ala Ala Trp Gln Ala Val Glu Pro Ser Asp Ile Ala Ala Cys Phe 
    370                 375                 380                 


Arg Glu Ala Gly Phe Gly Gly Gly Pro Asn Ala Thr Ile Thr Thr Ser 
385                 390                 395                 400 


Leu Lys Ser Glu Gly Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
                405                 410                 415     


Glu Glu Glu Gly Glu Gly Glu Glu Glu Glu Glu Glu Gly Glu Glu Glu 
            420                 425                 430         


Glu Glu Glu Gly Gly Glu Gly Glu Glu Leu Gly Glu Glu Glu Glu Val 
        435                 440                 445             


Glu Glu Glu Gly Asp Val Asp Ser Asp Glu Glu Glu Glu Glu Asp Glu 
    450                 455                 460                 


Glu Ser Ser Ser Glu Gly Leu Glu Ala Glu Asp Trp Ala Gln Gly Val 
465                 470                 475                 480 


Val Glu Ala Gly Gly Ser Phe Gly Ala Tyr Gly Ala Gln Glu Glu Ala 
                485                 490                 495     


Gln Cys Pro Thr Leu His Phe Leu Glu Gly Gly Glu Asp Ser Asp Ser 
            500                 505                 510         


Asp Ser Glu Glu Glu Asp Asp Glu Glu Glu Asp Asp Glu Asp Glu Asp 
        515                 520                 525             


Asp Asp Asp Asp Glu Glu Asp Gly Asp Glu Val Pro Val Pro Ser Phe 
    530                 535                 540                 


Gly Glu Ala Met Ala Tyr Phe Ala Met Val Lys Arg Tyr Leu Thr Ser 
545                 550                 555                 560 


Phe Pro Ile Asp Asp Arg Val Gln Ser His Ile Leu His Leu Glu His 
                565                 570                 575     


Asp Leu Val His Val Thr Arg Lys Asn His Ala Arg Gln Ala Gly Val 
            580                 585                 590         


Arg Gly Leu Gly His Gln Ser 
        595                 

