                         SEQUENCE LISTING

<110>  CEDARS-SINAI MEDICAL CENTER
       ROTTER, Jerome
       DUBINSKY, Marla
       TARGAN, Stephan
       TAYLOR, Kent
 
<120>  METHODS OF DETERMINING RESPONSIVENESS TO ANTI-TNF alpha THERAPY 
       IN INFLAMMATORY BOWEL DISEASE

<130>  67789-1351

<150>  61/118,290
<151>  2008-11-26

<150>  61/142,307
<151>  2009-01-02

<150>  61/182,552
<151>  2009-05-29

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  601
<212>  DNA
<213>  Homo sapiens

<400>  1
ccctcatgct agcaatcctt tctcagtcag ctctgccatt acagaggatg gttgtaacaa       60

attttgtcct ctgaaactaa gcaaaatata tcaatttctc acagctgaca gagccaaaag      120

gtggaaaggc ttgatataag taaaacaatg gaatgcttag ctgcaggcct agaaaggacc      180

ctttaattgc caggctctgt caccatatca agcgtggtag ggttcggggc tgaagcatac      240

ttacgaagac acacaaggca gtagctggta ccctcacttc tttaccagaa ccaggatgag      300

yatccacatt gtcctggggg actgggaagg aagagacaga gcgtctccta agaaataaca      360

taaagacaaa tattagacag gattgcagag gtttactgct catcaaattg ttagaaagga      420

ctccaagacg accttgctta agcagactgc ctctgttgat agcctgtcct tctagattct      480

tcaaactaca gaacaattca caaaaaaatc aaaagcaccc tcactcaaat gagaaagaga      540

gccagcacat gccttactct cctgcacact aacctgtgga ctccaaaacc caacaatgaa      600

a                                                                      601


<210>  2
<211>  646
<212>  DNA
<213>  Homo sapiens

<400>  2
aagatttatt gggggtaaga agagctaatg cctatgaaag ataaaggaga aaggagcaga       60

agtacggaga gaaaagacag ctttcagact gcagtccaga tctaactctg ggacgcaaga      120

gagggaagga taattctgtt gaaagagcat cagactgtga tgcggctgta agagtgtctc      180

aacgagccca gtggggagtt ccagccaaag attgcccagg agaagagtcg cactttgggc      240

agaaatggac aggcccgagc aaccctgcca tgttctgtca ttggctgggg gccacccagg      300

aggcaacatg gtctgacttg aatggtgtgg atccgaggct gcagcctgtc agctgtctgc      360

actccatgca acaggtcctt tgaatggcat gtgttcgtgg ctgccataaa ctgcagcctg      420

ccttttagcc ttacctcctt tgctcttgct ctctgacccy gtgttctggc aacactggcc      480

tgactacacg ccgtatcaca tacaaccaac tgcccatacc aaccccaacc ctgacctttg      540

ctcactcagt tctttctgcc tggaatgcca ctccttccca gttataccca gcaaaatcct      600

aatgtgcttt caaggcccaa cttaaaaatc atcttctctg gttgac                     646


<210>  3
<211>  601
<212>  DNA
<213>  Homo sapiens

<400>  3
atctttatgg aaagatgttc attattcact atattgaatt ttataatgtt aaactctgct       60

tttctttgca taaactatca gagattataa tactaaaatc ttaaatagtt aaattataag      120

taaattttgt gttttcccat atataaaagt gatatattta atgaatgcta gtaatcttaa      180

actggttata taattttata ctacaatgag taccttcgag aaagcttatg gtataagaaa      240

tactatttcc aaaacatttt tgttgcacat ttttggtatt agactcatca ttccaatgac      300

rtctggatta tgggaagaaa ggagcctgac tcttatgatg gaataaccac aaatcagaga      360

ggagtcacaa tagcagctct tggtgcagac tgtataccga tagtttttgc agatccagtc      420

aaaaaagcat gtggggttgc tcacgctggt aagtatactt aattaaacat ttagaatttt      480

actcattttg ttgtgcagga aaaattgtaa tttctttctg atggacatgg caaacagtta      540

attacattac actgtggtaa gtgtaatgat gggagaggcg gcatagtttt attataggga      600

c                                                                      601


<210>  4
<211>  634
<212>  DNA
<213>  Homo sapiens

<400>  4
cccgccctgc caaggaatgt cacgagcctc aagcagattt gctcttagat atttcttttt       60

aatcgagtct aacagtgatt gttgagccgt ccttcatttt tttttttttt tgtaagatgc      120

ctctgtcaag aaggagccac gagttggctt tcatggaatg ggtgctcttg gtggccaaat      180

agaaataaaa cctggctgtc tggtcctgat ccactcacag aagtggcgta aacaccttat      240

ttatgatctg ggacattcaa caccatctta taaaagattc atagaataca cattcacaca      300

cccacaaaaa tcaaragagc agattttcca aaaataggtg caagaaagat ccaacttcca      360

ggataaaatt ttagaaccaa catttccatt agcaaaagcg gtcttgtcta aaactctacc      420

gaccgcgcta aaatcccatt caaaacagag ctctggttac gtagatcgtg atcaataatg      480

agaaactgtg aggcgtcccc gtgggatctg acacttccta ggggagcttc tctccactgg      540

taataaagat ataattagga atttcaacta cctgtgattt tgccaactta cggcatttgt      600

tgagaatttc ggtccctgtg tttatgcaca cacc                                  634


<210>  5
<211>  801
<212>  DNA
<213>  Homo sapiens

<400>  5
ctagaacata tatgccaatg ggtagtgata cacaactgtc actggtaaag ttgcatacca       60

attcacaatc ctattctcat acccaagtta ctactacaca ttgctcttga gtcagtagct      120

gcatttgcca ccctggctca aaatatcagc catcacattt agtaaattct aacatacaaa      180

gcaaattagc actgatttat cagatttacc attgggtggg gtgaggagga ggaggatgct      240

ggctgactta gcccagtccc ttaagagctc tgttccagag aatatacttg tgctcttcct      300

ccatggccca gcatatgcac agggctccag tcatttgcct ccagcagggg gctcttccac      360

actcattcac agtcagctgg attccaatct ctgctcaagt rtgagcaatg tagatccagc      420

cccctggtta atgtattcat cactgttcaa gcccagtctc tttcagatgt tgagacagtg      480

gccctaactc tgtgtggctg gcccagagct gtgcacctac cctcactttc ataccacatt      540

aatttcagat ccttattgtc atgggtttcc caactacttt tttttcttca ggggaaacct      600

ccacaatgta gtttctaata tgttgaattc atactccaga aagtgtcctg tagaataatg      660

tcttactgaa aacggccatc acagccagga gtccttaact atgttctttg atacccttag      720

ttacagtttg ttgtcatgtt cttcacatct tgtgtgaaga ttgttcaagt attggccaaa      780

ggatatgtca ctatctaaaa t                                                801


<210>  6
<211>  401
<212>  DNA
<213>  Homo sapiens

<400>  6
atagctgtaa cactgtgtgc aggtatctgg ggtttctgtc gtgaccacgt ggcaggagct       60

gctgccactg ctgtctgatg ctcgccccac agtggaagga gatgctaaat tccgttacgc      120

attagaggtc agtgaaaagg aagatgcagt ttgttcccgt ccaggcacaa ggactcttga      180

atttgtccat agttaagaac rgctcatcca ggagcagagc gagaggccgg gctgcgcgtc      240

ctcatctcct ctcccagcct tcgcatcctc ctggctgcct cgcgtttcct ccacgggcct      300

ggctgaacgc acacacaggc ctgggggaga ctgcagagac acatcttcag ccacatcttc      360

tgtaaaacag tcactatggg atgacggtga ctggacagtg g                          401


<210>  7
<211>  601
<212>  DNA
<213>  Homo sapiens

<400>  7
acaatccaaa cagggtagtg gttacccctg aggagaaaac taggtaggag catggcggga       60

gaggaagatt gagaggtcta aggcaacttt atctactttc caaaatgttt taaaataaga      120

atgctttatt atttgtgtca tttttaaatt aataaagtag gcatgccatt ctgaaattcc      180

acgtctaaat ggcacaaaag tgtaagatag gcaccacagt tgcttataca acattactct      240

ccaaagatta tattcccaaa cgctttacct attccctctt agaaaagact tccagagtct      300

ytcagtcttc atcttggcct gtatttttaa cccattaggc atcctcttgg ggtaacttca      360

gcaggctcca taggtacaac aaccttcacg tgatctttaa attagctcca taatagtgat      420

aatgaggcag gaaccttgag ataaaaagca gatattacag gttccacttt cgcttctagc      480

actaatgatt acatggaaag tcgctcaacc caagttatag cttccacatt catatggaag      540

gaataacaac aagaattata cctcactcct actcagggac atgcaggtag gaaccacaac      600

a                                                                      601


<210>  8
<211>  401
<212>  DNA
<213>  Homo sapiens

<400>  8
aacggatcat caactccagg atactcactt ttgctaaatt ctcaatactt tgtaaagata       60

tcatgtccag gtgaacgtta aaataatctt accttgggga cctcataaga tgtggttcta      120

gtcaaacaca cttattccag gatatatttc agagtgactc caaattccca tctgttgcta      180

gaaccaatca tttctgccgt kccaaaaaat tatcgtagct cagaagacct atgttaaaaa      240

ggccaaaaaa aaaaaaggaa tcaattagca ttttaatgtt aaaatgaaac taatttccag      300

tagcaaaata atggttttta accatgacac ctgcagtttc aggcaagtgg cagacagcca      360

aacatatcca tagttgtaag gtgtcctact attagggagg a                          401


<210>  9
<211>  201
<212>  DNA
<213>  Homo sapiens

<400>  9
agctgatgtc tgtctcatgg gcaaatacaa caaatactga catagatggc ctcaagagaa       60

gaaaaagtgg caaaacacct tattgactgc ttgttcgcag rctaaggttg tgacgagaag      120

tacaagagaa tgaatttggc cagctatctg gagagtaggg tacctgtgaa gcccaggcct      180

ctaaatgggg tcctctcaca t                                                201


<210>  10
<211>  401
<212>  DNA
<213>  Homo sapiens

<400>  10
cttcatttca aaaaaagttt tggcatttac ggaaggcttc ttaaacttct tccatggttt       60

gacatcattg actcagataa aggcctagga agccattcct cctattcagg atctaaaaaa      120

gcagcagttc acatttataa cgcattacaa ccagaacttg aggcctaaga aatttctatg      180

tcgagtccac agtttcaaac rcaaattcac tcatcaaggc tttgttcagg catcagggaa      240

acatcctggc agcaagtata cctatataag gaaatattag gtcacgatcc cataactcca      300

acacacaaga gatgcaccac acactttagg agacttccaa agcagaaaaa cacaagagac      360

tagggagaat gacctctctt cctagtttat gccttcaagg t                          401


<210>  11
<211>  401
<212>  DNA
<213>  Homo sapiens

<400>  11
accataaatc aataagaaaa aacaaatgat gaacaattca gtatgagaat aagcaaagaa       60

tataaacaaa tcattcaaaa aggaggaaat taaagcttca gagaagcatg taaaggtaat      120

atccaactcc actaacaaga agggaaaaat tgaaatgaaa attaaaactg taatacagca      180

gtattcttat gagaaagaac rtagaatttc tgtgatacac tgtgctttca aaggcatata      240

gacaaagtac tcatgcattg ttagaagaag ggtaatttaa caatatctat caatgttaaa      300

aattgcttac atcttttgat gcagcaaatt gatgtatata tgtttcccta taaacatata      360

tacaaaggta ttcttcccat cattgtttgg aatagcccca a                          401


<210>  12
<211>  1001
<212>  DNA
<213>  Homo sapiens

<400>  12
agactcaatc acatgaggac tctaacttca gcagctattc caaatttgac cttataacta       60

aagaaaatca acacattatt ttgcacctga aatgcagttc ttgacgcggt gaattccccc      120

tccacccatc ccccgcatac ctggtaatga acatcatcag aagaagttga ttttaagcta      180

ggtagtcaag tacacatctt cattgtttaa ttgcagaact ctatcaaatc tccaactcaa      240

actatcctat gtgggctttc cacaaatgac agcatcattc tggctcattc gattcatcaa      300

caatttgctg atcagaccaa ctcaaaggta aatagcaatt attttagaaa ttgtaataag      360

ggacacgttg cagagagcag gaaataaatc tcaccaaaaa gtgagggcct gctaccttgg      420

tgaagtttct acatatggtt tggaagatat cctggtccca tctgaagttg ctagttgcgt      480

tgccacagct ccatgcagga rtgcctatga tggacaaaag tgaagaaaaa tcttcccggt      540

gggcagagtt ttgagcagag caccaagtaa ttcatttttt aatggaggta gaaattgatc      600

aatacataga tctatgttga ctgatgagca gtaacaaatt ggctgcataa tgggtaactt      660

ggaaaggata tagctaagag attttaggta agaaattttg ctgaataaat ctaaggataa      720

acttctttca gttggcacag aatgtgaaga tatatgtgcc caacataaat gttaacctag      780

gaaaaaccta ttagtaatta ggcggataag atactctgtt ctctagacat aattccccct      840

tttccccaac cactctgtcc ttgcaaatgt ggttcatgag caacatggct atgacagcag      900

agattaagtt atgcatggac tcactaaata atacctattg ctgagtgcct aacttgccaa      960

cagcaggttg gtactcactg ggtgcacact cagctggcac a                         1001


<210>  13
<211>  809
<212>  DNA
<213>  Homo sapiens

<400>  13
tggaaatctt gggaaaattt gcatgtaatt agtactccct tccagctctc cgaagtataa       60

aatacaatac attagggctt gtaacactaa tatcgctgag aacacagcta atgtgggaag      120

tctaattcgc cactaatatg cagatgccaa gctagttggt gcttgctttc acytgttttg      180

gctaattgtt ttcggtgtga tttagaaact ccatacctta tgatgcagtt gtacctgatg      240

caacaactca ccagtgctgg actgtgggag gtcacatcat ttagactgca aattcagaag      300

tgactttcga ggaaatttgg tcccgttccc aagcaataaa gccgtcgcat cataatcagc      360

ttagaacaat ttgccaatga tagttttctg tgttgcgcca tcagagattc tgattcagca      420

agtcctcgtt ggatctcata catctcaatt aaaaatcaac aatagatcgg gcgtggtggc      480

tcacgcctgt ctgtcatccc agcactttga gaggccaagc caggtggatc aggagttcca      540

gaccagcctg gccaacatgg tgaaacccca tctctgctaa aagtacaaaa attagccagg      600

cgtggtggtg catgcctgta gtcccagcta ctggggaggc tgaggcagga gaataacttg      660

agtccgggag gcggaggttg caatgagcca agatcgtgca actgtactcc agccctgggt      720

gacagagcaa gaatctgttc tcaaataatt aaataactaa gatattgatt aattaacaat      780

tcatgtcttt ttgaatgcga ccagaaaat                                        809


<210>  14
<211>  1008
<212>  DNA
<213>  Homo sapiens

<400>  14
aaaaaaaaaa aaaaaaaaag aaagaaagaa agaaagaaag gtaggaagga caaaggaact       60

cctgcctcct gtgtcctccc acagcatatc actggggggc cctgtcaaat gaggggcact      120

aggttgagaa ctataaaaca atctgttgat ttatgcattt aaaacctcaa gacttttttt      180

tttttttttt tctggagatg gagtttcgct cttgttgccc aggctggagt gcaatggtgt      240

gatctcggct cactgtaacc tccaccttcc gggttcaagc cattcttttg cctcagcctc      300

cccagtagct ggaattataa gtaagcacca ccatgcccgg ctaatttttt atatttttag      360

tagagacgag gtttttccat gttagtcagg ctggtctcga actcccgacc tcaggtggtc      420

ctcccacctc agcctcccaa agtgctggaa ttacaggcat gagccaccac gcctggttgg      480

acttttgtct caaatgaaat tgttaaagga acccacattt tacaaaatat gtggtatgtg      540

gtggaaaaaa cttccttcca tgagtctctt ttccagggta tatgggagat aaggagggga      600

agaccagggc ttttaggccc ggctcttcct ggtgctgaga tactggaaga ctgccttgta      660

aagcatctag ggatgtaaat tcaggaaaag ttctttaagc attagaccaa agctgagtga      720

gctgggagat tatggatctc gcatgtagac ctgataacgg gcatcggtag gatcttaatc      780

cttggagagc caggtgcctc cctctgccca catgatgtgc atgcaagtaa aaaagaaaca      840

tggaactaaa ttatctccca gtttttcctc ctccgcagtc ccctccagct ctatccttcc      900

tttctaccaa gagcagagcc acttagagga caaggtactc aycacgtctg gctcaggtcc      960

aatgctgtga agaggtacca gatacaagag acaggtggga ctggctca                  1008


<210>  15
<211>  601
<212>  DNA
<213>  Homo sapiens

<400>  15
agatgcggta ttttatgaaa tacaagaaga aaaatgctct aaaacccata atcataaaca       60

cagcatatgg aaaaatgaaa gcgctagttt tgagttagaa gcatctttta tctacttcca      120

ctccctccac tttctggtca atattagata cataatcaga gaaatgctta aatttcacca      180

aaggcttgct tgagttggaa gcttgatttt ttttttagaa gaaattcccc accatccatt      240

ctactgcaaa gattttcttt ctcaagtgct ttcacctgtc aaaagccctc tgtccagata      300

yttagcagat ccctccactc tctcattctg caaggcagag ggaagaggag gctacattga      360

gtgagtgtct accatgaacc aggctcagac acagacatct ggcatctcat gccggcctct      420

cagaggggct gcgaggacag tgggctgccc acgggctctc gggttcagag aggcagtgag      480

cctggctgaa gggcaccagc taggaaatgg cagagccaga ttctgcacat ccccaaagcc      540

caagacacct ccctacctcc cagacttctc catttgagta tatgcgccct gacgaaaagc      600

a                                                                      601


<210>  16
<211>  501
<212>  DNA
<213>  Homo sapiens

<400>  16
ctatctgcat ttcagagagg gcttttcagt tttgttataa aacctcatta cttttttatt       60

acagacttag tggagccttc tctgttgaat tgaatcatat gattcactat tagctggaca      120

tttaatacta tatcgtcttt atattgttca ggattcttct cagttctttt atttgcactt      180

tggaaatgtc tcaggagaag aaattgaaag atgatagttc tttcaaataa ttattccctg      240

tcccaggaag rtagtgtttt aaagacaatt atttaaacaa aatatactac cattttctaa      300

ttctttttga tttaagctcc ctacaataat gaatgagaag aatgagaatt aagcggttta      360

gaaaacaatg tggtttttgg caaaatcaaa atatttttaa aaatccttta agatcatcag      420

tgcataccac atgttttgtg aagcttttgt agaatctctg aggtgtccac ctctcttatt      480

gtacttattc acatctcttc c                                                501


<210>  17
<211>  601
<212>  DNA
<213>  Homo sapiens

<400>  17
aaaccgcttt acaacactta caactttatt taacagcaga aagctcaaag ctgccatgca       60

gagggaagct atgtagactc tggaagcctt gaagcttagg agcataggaa ttacagctct      120

gtctggttgg cttaaccaca tccaggcatg gaggcaagga aaaaaaaaaa aactcaaagc      180

tttgtttgga ggatggtact aggaaagaac taggaaacta gtgagagaag gtaccaagct      240

atgcctttgt ccacccacta ttcaatttac aaatatttct tggtcctata tcaggcactc      300

yattgggtac taggaataaa tacgcagatg aatgaggcat ggctctttcc ccaaaaagga      360

cttatatgtg ctcaaaatgt gttacagaaa tcccatgagg attcttggat attccaagag      420

ggtcaaattt cattgctctg tttttcatac ctgggactgg gctttagtag actctctctg      480

gtttcctgaa gcttcatacc ccacatctgc cctactgtga gagtccaacc ccagggctct      540

agctggcttc tctcaactgt tctacagttt tctaggccac agcttgagat gtgacagaaa      600

g                                                                      601


<210>  18
<211>  801
<212>  DNA
<213>  Homo sapiens

<400>  18
tttgataagg aagtgagtgg tgtgaaatcc aggctcaaga acaaaagccc tacaagcctg       60

tacccaacgg ggccactggc ctagaatggt aataaataga attgggtgac aaccttgaag      120

gtcacccgtg gttcagctct ggaggtgtcc ttgtttgtac tcactttgag taaccatcaa      180

cttataaata gcctcaggcc aattgcccag tgatgatttt gactgtcgct tgccaggggc      240

ctgggcttgt ggtttggttg tgagtctgtc atggtctctg tgacctcaga ggaggaggaa      300

ggaagatgat gatggatgct tctagtgatg caagcaacaa acatttttgg acaatgtgcc      360

caataccatt ctctgtactc tgcatgagtt aacccttcag kcttcaaaca acgctttgag      420

gtaggtgagg agactgagca ctaaaaaggt gaatgcggag ccagtgtgag cacaaaaggc      480

ctggttccct gctagaccgt gcctcctctt ggctggagct ctatggaaag agttggaacc      540

agggagcctt ggttaaaata tcagctccat cccttatgac cttgggcaac ttacaaatct      600

ccaaatctgt attttcacct tttaactaga ataatgtatg tcaattatag ggtgttagga      660

ttaaatgaga aaatgtacat aaaacttttg gggcattgtc tggcactggg taagtactca      720

atgaaaaaag gtaatggttt tttaacttgt ttaatgtttc taagccttag gttttccact      780

tataaaatga aagcgtcatt a                                                801


