
                                SEQUENCE LISTING

<110> University of Rochester

<120> ANIMAL MODEL FOR OSTEOARTHRITIS AND INTERVERTEBRAL 
DISC DISEASE

<130> 20724/0032WO1

<150> US 61/117,766
<151> 2008-11-25      

<150> US 61/231,852	
<151> 2009-08-06   

<160> 65

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 3008 
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 1
ctcacaaagc cgagtccagc tggagccacc tccagactct ctggccagag cctcagagtg 60
gccaacagtc cctggccagc ggttgctcta tccaggctaa gggcacccac tcccctggag 120
attcctgaac ctgggccagg aagagccgaa ctagacaagc gtctccaatc catcccgttt 180
tgtccccggg gttgtctgca gtcccgttag tcccttccct ggcctgttcg ccccttagac 240
ctccacacag gtctccctct gtgtaggaat tcaccagacc ctgtcctagc cacccgctca 300
gttccccctt ctacctaggc cttttctagc tagttggatg ggggatgggt tagggaggct 360
gtggtccccg agactccagg tgggagctca cgggcaggta ctccgcaaag gagctggaag 420
gcaggtctgg aaaactgtcc cccagattta ggattctgga caacgtccat ctgctcatgc 480
tttggtcccc cacgcacctc cccgcctcct aaattcccca tccccacctt tcttgctcct 540
ttctgttgct tcgtcctctc tgccttgggt ctaaaactcc aggttatgcc tctgcaaaca 600
accccctccc ttctaacccc agcagaactc cgaggaaagg ggcccgatgc tcccccccct 660
tcccgcctgt ggttagaggg ggcagtgtgg cagtcccaag tgggggcgac cggagctgtc 720
tcggtgcccc gcccgatcag gccactgggc acattggggg cgggaagctg ggctcacgaa 780
aggggcgact ggccttggca ggtgtgggct ctggtccggc ctgggcgggc tccgggggcg 840
gggtctcagg ttacagcccc gcggggggct agggggcggc ccgcggtttg ggccggtttg 900
ccagcctttg gagcgaccgg gagcatataa ctggagcctc tgaaggggga agacgcagag 960
cgccgctggg ctgccgggtc tcctgcctcc tcctgctcct agggcctcct gcatgaggga 1020
gcggtagaga ccatgtccaa tttactgacc gtacaccaaa atttgcctgc attaccggtc 1080
gatgcaacga gtgatgaggt tcgcaagaac ctgatggaca tgttcaggga tcgccaggcg 1140
ttttctgagc atacctggaa aatgcttctg tccgtttgcc ggtcgtgggc ggcatggtgc 1200
aagttgaata accggaaatg gtttcccgca gaacctgaag atgttcgcga ttatcttcta 1260
tatcttcagg cgcgcggtct ggcagtaaaa actatccagc aacatttggg ccagctaaac 1320
atgcttcatc gtcggtccgg gctgccacga ccaagtgaca gcaatgctgt ttcactggtt 1380
atgcggcgga tccgaaaaga aaacgttgat gccggtgaac gtgcaaaaca ggctctagcg 1440
ttcgaacgca ctgatttcga ccaggttcgt tcactcatgg aaaatagcga tcgctgccag 1500
gatatacgta atctggcatt tctggggatt gcttataaca ccctgttacg tatagccgaa 1560
attgccagga tcagggttaa agatatctca cgtactgacg gtgggagaat gttaatccat 1620
attggcagaa cgaaaacgct ggttagcacc gcaggtgtag agaaggcact tagcctgggg 1680
gtaactaaac tggtcgagcg atggatttcc gtctctggtg tagctgatga tccgaataac 1740
tacctgtttt gccgggtcag aaaaaatggt gttgccgcgc catctgccac cagccagcta 1800
tcaactcgcg ccctggaagg gatttttgaa gcaactcatc gattgattta cggcgctaag 1860
gatgactctg gtcagagata cctggcctgg tctggacaca gtgcccgtgt cggagccgcg 1920
cgagatatgg cccgcgctgg agtttcaata ccggagatca tgcaagctgg tggctggacc 1980
aatgtaaata ttgtcatgaa ctatatccgt aacctggata gtgaaacagg ggcaatggtg 2040
cgcctgctgg aagatggcga tctcgagcca tctgctggag acatgagagc tgccaacctt 2100
tggccaagcc cgctcatgat caaacgctct aagaagaaca gcctggcctt gtccctgacg 2160
gccgaccaga tggtcagtgc cttgttggat gctgagcccc ccatactcta ttccgagtat 2220
gatcctacca gacccttcag tgaagcttcg atgatgggct tactgaccaa cctggcagac 2280
agggagctgg ttcacatgat caactgggcg aagagggtgc caggctttgt ggatttgacc 2340
ctccatgatc aggtccacct tctagaatgt gcctggctag agatcctgat gattggtctc 2400
gtctggcgct ccatggagca cccagtgaag ctactgtttg ctcctaactt gctcttggac 2460
aggaaccagg gaaaatgtgt agagggcatg gtggagatct tcgacatgct gctggctaca 2520
tcatctcggt tccgcatgat gaatctgcag ggagaggagt ttgtgtgcct caaatctatt 2580
attttgctta attctggagt gtacacattt ctgtccagca ccctgaagtc tctggaagag 2640
aaggaccata tccaccgagt cctggacaag atcacagaca ctttgatcca cctgatggcc 2700
aaggcaggcc tgaccctgca gcagcagcac cagcggctgg cccagctcct cctcatcctc 2760
tcccacatca ggcacatgag taacaaaggc atggagcatc tgtacagcat gaagtgcaag 2820
aacgtggtgc ccctctatga cctgctgctg gaggcggcgg acgcccaccg cctacatgcg 2880
cccactagcc gtggaggggc atccgtggag gagacggacc aaagccactt ggccactgcg 2940
ggctctactt catcgcattc cttgcaaaag tattacatca cgggggaggc agagggtttc 3000
cctgccac							  3008

<210> 2
<211> 728
<212> DNA
<213> Artificial Sequence 

<220> 
<223> Synthetic Construct

<400> 2
gtttgtgatt cagatgcctg tctgaggatc tgcctcatag ccctgctgcc tggccagact 60 
gcctttgttc tcttccataa cttcgtatag catacattat acgaagttat cttctgcaca 120
ctaccactgg cttggtgaaa taatcagcaa gccaccgatg ggatctaatg agtgctctca 180
ggccacccct gtcccatgga gctcatactg accctcacct gctctccttg gctgcctttc 240
taacagtatt tcaatgggtc attgtcgtag atggcttctt caggtagcat tttcagttca 300
ctaacatact ctgtttttac agctgacctg atggagttgg acatggccat ggagccggac 360
agaaaagctg ctgtcagcca ctggcagcag cagtcttact tggattctgg aatccattct 420
ggtgccacca ccacagctcc ttccctgagt ggcaagggca accctgagga agaagatgtt 480
gacacctccc aagtccttta tgaatgggag caaggctttt cccagtcctt cacgcaagag 540
caagtagctg gtaaagcatt tgtgtttgga agataacttc gtatagcata cattatacga 600
agttatctag cattaagttt cttgacaggg ctgtgtgaca gctcagccac agcacaagtg 660
ggttgaagga agggcggagg gtagcggagt cccacatgcc tagtgagtgt tggatttacc 720
tttttcag							  728

<210> 3
<211> 232
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 3
gtttgtgatt cagatgcctg tctgaggatc tgcctcatag ccctgctgcc tggccagact 60 
gcctttgttc tcttccataa cttcgtatag catacattat acgaagttat ctagcattaa 120
gtttcttgac agggctgtgt gacagctcag ccacagcaca agtgggttga aggaagggcg 180
gagggtagcg gagtcccaca tgcctagtga gtgttggatt tacctttttc ag 	  232

<210> 4
<211> 21
<212> RNA
<213> Mus musculus

<400> 4
aaggcuuuuc ccaguccuuc a						  21

<210> 5
<211> 21
<212> RNA
<213> Mus musculus

<400> 5
aagaugaugg ugugccaagu g				                  21

<210> 6
<211> 19
<212> RNA
<213> Mus musculus

<400> 6
cugcgacucu ugcgggaau                     			  19

<210> 7
<211> 19
<212> RNA
<213> Mus musculus

<400> 7
ucaaaugguc ccaaacgaa                          			  19

<210> 8
<211> 19
<212> RNA
<213> Mus musculus

<400> 8
agacuaugga caaagauua			                          19

<210> 9
<211> 19
<212> RNA
<213> Mus musculus

<400> 9
ggcccauaca guuugaaua                     			  19

<210> 10
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 10
agggtacctg aagctcagcg                     			  20

<210> 11
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 11
cagtggctga cagcagcttt 				                  20

<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 12
tgaatcagct ggcttttgtg           			          20

<210> 13
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 13
accttccagt aggggcaact			                          20

<210> 14
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 14
tttgagaaca cggggaaga 				                  19

<210> 15
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 15
actttgttgc caattccagg			                          20

<210> 16
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 16
aggacctggt agtgcgagtg  				                  20

<210> 17
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 17
gcgtgtggcg aagaa  			                          15

<210> 18
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 18
gcttttctcg tttgtggagc			                          20

<210> 19
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 19
tggaagtggc ccatttagag			                          20

<210> 20
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 20
gaggaggagg aagagcagag  				                  20

<210> 21
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 21
tgggatgttc tccagatgtt             			          20

<210> 22
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 22
ctcagaagaa ggttggctgg					          20

<210> 23
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 23
acctcgctca ccttgaagaa			                          20

<210> 24
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 24
tccttcctgc tgaagaagac ca		                          22

<210> 25
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 25
taaagctggt gatggtgttg gc		                          22

<210> 26
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 26
gcatggccaa gaagacatcc                     			  20

<210> 27
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 27
cctcgggttt ccacgtctc			                          19

<210> 28
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 28
ccacaccaaa ttcctgttca			                          20

<210> 29
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 29
actggtaagt ggggcaagac 				                  20

<210> 30
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 30
accccaagga cctaaaggaa				                  20

<210> 31
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 31
ccccaggata ccctgttttt			                          20

<210> 32
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 32
agggaggatc aagtcccg    				                  18

<210> 33
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 33
gaacagactc cggcgcta         			                  18

<210> 34
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 34
tcctgaccaa aaacctcaaa gg		                          22

<210> 35
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 35
tcgttcatgc agagcctgc               				  19

<210> 36
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 36
ccttgctgct caacctccac                   			  20

<210> 37
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 37
cacacaggat ggcttgaaga               				  20

<210> 38
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 38
acagcgttca tcttcgcaat cacc      		                  24

<210> 39
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 39
aaatcgatgt tgtcactgca gccc 				          24

<210> 40
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 40
ggctcctctc ggatacctct  					          20

<210> 41
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 41
gggcatgatc tccacgtagt   				          20

<210> 42
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 42
ctcaaaggcc tgatccagag c 			                  21

<210> 43
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 43
gtcccttgtg tcaccacctt				                  20

<210> 44
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 44
tgcatgatcc catgcccttt 				                  20

<210> 45
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 45
accaaacagc tgcaacacct 				                  20

<210> 46
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 46
tacgtgcaag tgaatgcggt				                  20

<210> 47
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 47
tggttctttc cctgtgagca 					          20

<210> 48
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 48
ttcctccaca acacatggca     				          20

<210> 49
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Synthetic Construct

<400> 49
atgcaaggca agggcaaaca                                             20

<210> 50
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Synthetic Construct

<400> 50
tgctatggca tcaagtggct                                             20

<210> 51
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Synthetic Construct

<400> 51
ccagctgttt acagtgttgc gt                                          22

<210> 52
<211> 20
<212> DNA
<213> Artifical Sequence

<220>
<223> Synthetic Construct

<400> 52
atccgcaagc tgcaatgcta	                                          20

<210> 53
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Synthetic Construct

<400> 53
tgtgcttggg aaaccggaaa                                             20

<210> 54
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Synthetic Construct

<400> 54
tggcctggtt caaggaaagt                                             20

<210> 55
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 55
tgcctttgag cttcagcgtt						  20

<210> 56
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 56
tggaaagaac aagcgccact 						  20

<210> 57
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 57
tgcaaagcca tccgcatcaa						  20

<210> 58
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 58
tggtccgcgt aaagtatggg aa 					  22

<210> 59
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 59
ctgcattgcc acccatggta aa  					  22

<210> 60
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 60
tcagtggatc ttcgcagttg ga 					  22

<210> 61
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 61
acaggatgcc ttccttggat ct 					  22

<210> 62
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 62
tctggcttta acgaggagcc tt					  22

<210> 63
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 63
ggcaagcagg gttggaatct tt					  22

<210> 64
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 64
tgcatggagg ccatcatctt 						  20

<210> 65
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 65
tgcaaatggc agcaccaaca						  20
