                         SEQUENCE LISTING

<110>  Biogen Idec MA Inc.
       Mi, Sha
       Rhodes, Kenneth J.
       Pepinsky, R. Blake
 
<120>  Use of DR6 Antagonists to Promote Survival of Cells of the 
            Nervous System

<130>  2159.165PC01/EJH/CLD

<141>  To Be Assigned
<142>  Herewith

<151>  61/117,917
<152>  2008-11-25

<160>  166   

<170>  PatentIn version 3.3

<210>  1
<211>  3660
<212>  DNA
<213>  Homo sapiens

<400>  1
gccaccacgt gtgtccctgc gcccggtggc caccgactca gtccctcgcc gaccagtctg     60

ggcagcggag gagggtggtt ggcagtggct ggaagcttcg ctatgggaag ttgttccttt    120

gctctctcgc gcccagtcct cctccctggt tctcctcagc cgctgtcgga ggagagcacc    180

cggagacgcg ggctgcagtc gcggcggctt ctccccgcct gggcggccgc gccgctgggc    240

aggtgctgag cgcccctaga gcctcccttg ccgcctccct cctctgcccg gccgcagcag    300

tgcacatggg gtgttggagg tagatgggct cccggcccgg gaggcggcgg tggatgcggc    360

gctgggcaga agcagccgcc gattccagct gccccgcgcg ccccgggcgc ccctgcgagt    420

ccccggttca gccatgggga cctctccgag cagcagcacc gccctcgcct cctgcagccg    480

catcgcccgc cgagccacag ccacgatgat cgcgggctcc cttctcctgc ttggattcct    540

tagcaccacc acagctcagc cagaacagaa ggcctcgaat ctcattggca cataccgcca    600

tgttgaccgt gccaccggcc aggtgctaac ctgtgacaag tgtccagcag gaacctatgt    660

ctctgagcat tgtaccaaca caagcctgcg cgtctgcagc agttgccctg tggggacctt    720

taccaggcat gagaatggca tagagaaatg ccatgactgt agtcagccat gcccatggcc    780

aatgattgag aaattacctt gtgctgcctt gactgaccga gaatgcactt gcccacctgg    840

catgttccag tctaacgcta cctgtgcccc ccatacggtg tgtcctgtgg gttggggtgt    900

gcggaagaaa gggacagaga ctgaggatgt gcggtgtaag cagtgtgctc ggggtacctt    960

ctcagatgtg ccttctagtg tgatgaaatg caaagcatac acagactgtc tgagtcagaa   1020

cctggtggtg atcaagccgg ggaccaagga gacagacaac gtctgtggca cactcccgtc   1080

cttctccagc tccacctcac cttcccctgg cacagccatc tttccacgcc ctgagcacat   1140

ggaaacccat gaagtccctt cctccactta tgttcccaaa ggcatgaact caacagaatc   1200

caactcttct gcctctgtta gaccaaaggt actgagtagc atccaggaag ggacagtccc   1260

tgacaacaca agctcagcaa gggggaagga agacgtgaac aagaccctcc caaaccttca   1320

ggtagtcaac caccagcaag gcccccacca cagacacatc ctgaagctgc tgccgtccat   1380

ggaggccact gggggcgaga agtccagcac gcccatcaag ggccccaaga ggggacatcc   1440

tagacagaac ctacacaagc attttgacat caatgagcat ttgccctgga tgattgtgct   1500

tttcctgctg ctggtgcttg tggtgattgt ggtgtgcagt atccggaaaa gctcgaggac   1560

tctgaaaaag gggccccggc aggatcccag tgccattgtg gaaaaggcag ggctgaagaa   1620

atccatgact ccaacccaga accgggagaa atggatctac tactgcaatg gccatggtat   1680

cgatatcctg aagcttgtag cagcccaagt gggaagccag tggaaagata tctatcagtt   1740

tctttgcaat gccagtgaga gggaggttgc tgctttctcc aatgggtaca cagccgacca   1800

cgagcgggcc tacgcagctc tgcagcactg gaccatccgg ggccccgagg ccagcctcgc   1860

ccagctaatt agcgccctgc gccagcaccg gagaaacgat gttgtggaga agattcgtgg   1920

gctgatggaa gacaccaccc agctggaaac tgacaaacta gctctcccga tgagccccag   1980

cccgcttagc ccgagcccca tccccagccc caacgcgaaa cttgagaatt ccgctctcct   2040

gacggtggag ccttccccac aggacaagaa caagggcttc ttcgtggatg agtcggagcc   2100

ccttctccgc tgtgactcta catccagcgg ctcctccgcg ctgagcagga acggttcctt   2160

tattaccaaa gaaaagaagg acacagtgtt gcggcaggta cgcctggacc cctgtgactt   2220

gcagcctatc tttgatgaca tgctccactt tctaaatcct gaggagctgc gggtgattga   2280

agagattccc caggctgagg acaaactaga ccggctattc gaaattattg gagtcaagag   2340

ccaggaagcc agccagaccc tcctggactc tgtttatagc catcttcctg acctgctgta   2400

gaacataggg atactgcatt ctggaaatta ctcaatttag tggcagggtg gttttttaat   2460

tttcttctgt ttctgatttt tgttgtttgg ggtgtgtgtg tgtgtttgtg tgtgtgtgtg   2520

tgtgtgtgtg tgtgtgtgtg tttaacagag aatatggcca gtgcttgagt tctttctcct   2580

tctctctctc tctttttttt ttaaataact cttctgggaa gttggtttat aagcctttgc   2640

caggtgtaac tgttgtgaaa tacccaccac taaagttttt taagttccat attttctcca   2700

ttttgccttc ttatgtattt tcaagattat tctgtgcact ttaaatttac ttaacttacc   2760

ataaatgcag tgtgactttt cccacacact ggattgtgag gctcttaact tcttaaaagt   2820

ataatggcat cttgtgaatc ctataagcag tctttatgtc tcttaacatt cacacctact   2880

ttttaaaaac aaatattatt actattttta ttattgtttg tcctttataa attttcttaa   2940

agattaagaa aatttaagac cccattgagt tactgtaatg caattcaact ttgagttatc   3000

ttttaaatat gtcttgtata gttcatattc atggctgaaa cttgaccaca ctattgctga   3060

ttgtatggtt ttcacctgga caccgtgtag aatgcttgat tacttgtact cttcttatgc   3120

taatatgctc tgggctggag aaatgaaatc ctcaagccat caggatttgc tatttaagtg   3180

gcttgacaac tgggccacca aagaacttga acttcacctt ttaggatttg agctgttctg   3240

gaacacattg ctgcactttg gaaagtcaaa atcaagtgcc agtggcgccc tttccataga   3300

gaatttgccc agctttgctt taaaagatgt cttgtttttt atatacacat aatcaatagg   3360

tccaatctgc tctcaaggcc ttggtcctgg tgggattcct tcaccaatta ctttaattaa   3420

aaatggctgc aactgtaaga acccttgtct gatatatttg caactatgct cccatttaca   3480

aatgtacctt ctaatgctca gttgccaggt tccaatgcaa aggtggcgtg gactcccttt   3540

gtgtgggtgg ggtttgtggg tagtggtgaa ggaccgatat cagaaaaatg ccttcaagtg   3600

tactaattta ttaataaaca ttaggtgttt gttaaaaaaa aaaaaaaaaa aaaaaaaaaa   3660


<210>  2
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Thr Ser Pro Ser Ser Ser Thr Ala Leu Ala Ser Cys Ser Arg 
1               5                   10                  15      


Ile Ala Arg Arg Ala Thr Ala Thr Met Ile Ala Gly Ser Leu Leu Leu 
            20                  25                  30          


Leu Gly Phe Leu Ser Thr Thr Thr Ala Gln Pro Glu Gln Lys Ala Ser 
        35                  40                  45              


Asn Leu Ile Gly Thr Tyr Arg His Val Asp Arg Ala Thr Gly Gln Val 
    50                  55                  60                  


Leu Thr Cys Asp Lys Cys Pro Ala Gly Thr Tyr Val Ser Glu His Cys 
65                  70                  75                  80  


Thr Asn Thr Ser Leu Arg Val Cys Ser Ser Cys Pro Val Gly Thr Phe 
                85                  90                  95      


Thr Arg His Glu Asn Gly Ile Glu Lys Cys His Asp Cys Ser Gln Pro 
            100                 105                 110         


Cys Pro Trp Pro Met Ile Glu Lys Leu Pro Cys Ala Ala Leu Thr Asp 
        115                 120                 125             


Arg Glu Cys Thr Cys Pro Pro Gly Met Phe Gln Ser Asn Ala Thr Cys 
    130                 135                 140                 


Ala Pro His Thr Val Cys Pro Val Gly Trp Gly Val Arg Lys Lys Gly 
145                 150                 155                 160 


Thr Glu Thr Glu Asp Val Arg Cys Lys Gln Cys Ala Arg Gly Thr Phe 
                165                 170                 175     


Ser Asp Val Pro Ser Ser Val Met Lys Cys Lys Ala Tyr Thr Asp Cys 
            180                 185                 190         


Leu Ser Gln Asn Leu Val Val Ile Lys Pro Gly Thr Lys Glu Thr Asp 
        195                 200                 205             


Asn Val Cys Gly Thr Leu Pro Ser Phe Ser Ser Ser Thr Ser Pro Ser 
    210                 215                 220                 


Pro Gly Thr Ala Ile Phe Pro Arg Pro Glu His Met Glu Thr His Glu 
225                 230                 235                 240 


Val Pro Ser Ser Thr Tyr Val Pro Lys Gly Met Asn Ser Thr Glu Ser 
                245                 250                 255     


Asn Ser Ser Ala Ser Val Arg Pro Lys Val Leu Ser Ser Ile Gln Glu 
            260                 265                 270         


Gly Thr Val Pro Asp Asn Thr Ser Ser Ala Arg Gly Lys Glu Asp Val 
        275                 280                 285             


Asn Lys Thr Leu Pro Asn Leu Gln Val Val Asn His Gln Gln Gly Pro 
    290                 295                 300                 


His His Arg His Ile Leu Lys Leu Leu Pro Ser Met Glu Ala Thr Gly 
305                 310                 315                 320 


Gly Glu Lys Ser Ser Thr Pro Ile Lys Gly Pro Lys Arg Gly His Pro 
                325                 330                 335     


Arg Gln Asn Leu His Lys His Phe Asp Ile Asn Glu His Leu Pro Trp 
            340                 345                 350         


Met Ile Val Leu Phe Leu Leu Leu Val Leu Val Val Ile Val Val Cys 
        355                 360                 365             


Ser Ile Arg Lys Ser Ser Arg Thr Leu Lys Lys Gly Pro Arg Gln Asp 
    370                 375                 380                 


Pro Ser Ala Ile Val Glu Lys Ala Gly Leu Lys Lys Ser Met Thr Pro 
385                 390                 395                 400 


Thr Gln Asn Arg Glu Lys Trp Ile Tyr Tyr Cys Asn Gly His Gly Ile 
                405                 410                 415     


Asp Ile Leu Lys Leu Val Ala Ala Gln Val Gly Ser Gln Trp Lys Asp 
            420                 425                 430         


Ile Tyr Gln Phe Leu Cys Asn Ala Ser Glu Arg Glu Val Ala Ala Phe 
        435                 440                 445             


Ser Asn Gly Tyr Thr Ala Asp His Glu Arg Ala Tyr Ala Ala Leu Gln 
    450                 455                 460                 


His Trp Thr Ile Arg Gly Pro Glu Ala Ser Leu Ala Gln Leu Ile Ser 
465                 470                 475                 480 


Ala Leu Arg Gln His Arg Arg Asn Asp Val Val Glu Lys Ile Arg Gly 
                485                 490                 495     


Leu Met Glu Asp Thr Thr Gln Leu Glu Thr Asp Lys Leu Ala Leu Pro 
            500                 505                 510         


Met Ser Pro Ser Pro Leu Ser Pro Ser Pro Ile Pro Ser Pro Asn Ala 
        515                 520                 525             


Lys Leu Glu Asn Ser Ala Leu Leu Thr Val Glu Pro Ser Pro Gln Asp 
    530                 535                 540                 


Lys Asn Lys Gly Phe Phe Val Asp Glu Ser Glu Pro Leu Leu Arg Cys 
545                 550                 555                 560 


Asp Ser Thr Ser Ser Gly Ser Ser Ala Leu Ser Arg Asn Gly Ser Phe 
                565                 570                 575     


Ile Thr Lys Glu Lys Lys Asp Thr Val Leu Arg Gln Val Arg Leu Asp 
            580                 585                 590         


Pro Cys Asp Leu Gln Pro Ile Phe Asp Asp Met Leu His Phe Leu Asn 
        595                 600                 605             


Pro Glu Glu Leu Arg Val Ile Glu Glu Ile Pro Gln Ala Glu Asp Lys 
    610                 615                 620                 


Leu Asp Arg Leu Phe Glu Ile Ile Gly Val Lys Ser Gln Glu Ala Ser 
625                 630                 635                 640 


Gln Thr Leu Leu Asp Ser Val Tyr Ser His Leu Pro Asp Leu Leu 
                645                 650                 655 


<210>  3
<211>  3626
<212>  DNA
<213>  Mus musculus

<400>  3
gtgtccccga gctgagtggc catccgactc agtccctcgc cggccggtct aggcagcgga     60

ggaggcgagt gcttgatagt ggctggaagc ttcgctatgg gaagtcgctc tttagcactg    120

tcgcggctag ccctgctctc tggttctccg cagccgctgt cgttggagag caccgggagg    180

cgcgggttgc gagcgcgcct gcttctcacc gcccgggcgc cagcgcccct gggcaggtgc    240

tgagcgcctt tcggagcctc ccctgctgcc tccctcttcc gcctgggtgc ctggctgctg    300

cagtgcacat gggctgctgg aggtagatgg gctcaccgcc cgtgaggcgg cggtggatgc    360

ggcgctgggc agaaacagcc accaattcca gctgccgtgg ggccgagcgc cccgggcgcc    420

gctgcgagcc ccgagctcgg ccatggggac ccgggcaagc agcatcaccg ccctcgcctc    480

ttgcagccgc accgccggcc aagtcggagc cacgatggtc gccggctctc ttctcctgct    540

tggattcctc agcaccatca cagctcaacc agaacaaaag actctgagtc tccctggcac    600

ctaccgccat gttgaccgta ccactggcca ggtgctaacc tgcgacaagt gcccagcagg    660

aacgtacgtc tccgagcact gtaccaacat gagcctgcga gtctgcagca gctgccccgc    720

ggggaccttt accaggcacg agaacggcat agagagatgc catgactgta gtcagccatg    780

tccatggccg atgattgaga gattaccttg tgctgccttg actgaccgag agtgcatctg    840

cccacctgga atgtatcagt ctaatggtac ctgcgctccc catacagtgt gccccgtggg    900

ctggggtgtg cggaagaaag ggacagagaa tgaagatgtg cgctgtaagc agtgcgctcg    960

gggtaccttc tctgacgtgc cttccagtgt gatgaagtgt aaagctcaca cggactgtct   1020

gggtcagaac ctggaggtgg tcaagccagg gaccaaggag acagacaacg tctgtggcat   1080

gcgcctgttc ttctccagca caaacccacc ttcctctggc acagttacct tttctcaccc   1140

tgagcatatg gaatcccacg atgtcccttc ctccacctat gagccccaag gcatgaactc   1200

aacagattcc aactctactg cctctgttag aactaaggta ccaagtggca tcgaggaagg   1260

gacagtgcct gacaatacga gctcaaccag tgggaaggaa ggcactaata ggaccctgcc   1320

aaacccacca caagttaccc accagcaagc cccccaccac agacacattc tgaagctgct   1380

gccatcgtcc atggaggcca cgggtgagaa gtccagcaca gccatcaagg cccccaagag   1440

gggtcacccc agacagaacg ctcacaagca tttcgacatc aacgagcact tgccttggat   1500

gatcgtcctc ttccttctgc tggtcctggt gctgatagtg gtgtgcagta tccgaaagag   1560

ctccaggact ctcaaaaagg ggccccggca ggatcccagc gccatagtgg aaaaggcggg   1620

gctgaagaag tccctgactc ccacccagaa ccgggagaaa tggatctact accgcaacgg   1680

ccatggtatt gacatcttga agcttgtagc agcccaggtg ggaagccagt ggaaggacat   1740

ctatcagttt ctttgcaacg ccagcgagag ggaggtggcg gccttctcca atggatacac   1800

tgcagatcat gaacgggcct acgcggctct gcagcactgg accatccgtg gccctgaggc   1860

cagccttgcc cagctcatta gcgccttgcg ccagcaccga cgcaatgatg ttgtggagaa   1920

gattcgtggg ctgatggaag acaccacgca gttggaaaca gacaaactgg ctctccccat   1980

gagccccagt ccgcttagcc cgagccccat gcccagtcct aacgtgaaac ttgagaattc   2040

cactctcctg acagtggagc cctcaccgct ggacaagaac aagtgcttct tcgtggacga   2100

gtcagagccc cttctgcgat gcgactccac atccagtggc tcttcagcac tgagcagaaa   2160

cggctccttt attaccaaag aaaagaagga cacagtgttg cggcaggtcc gcctggaccc   2220

ctgtgacttg cagcccatct ttgatgacat gctgcatatc ctgaaccccg aggagctgcg   2280

ggtgattgaa gagattcccc aggctgagga caaactggac cgcctcttcg agatcattgg   2340

ggtcaagagc caagaagcca gccagaccct cttggactct gtgtacagtc atcttcctga   2400

cctattgtag aacacagggg cactgcattc tgggaatcaa cctactggcg gggtgatttc   2460

atttcgtttc tgacttttgt gttttggtgt gtatgtatgt gtttaacaga gtgtatggcc   2520

ggtgagtttg ggttctttct ttctttcttt ctttctttct ttctttcttt ctttctttct   2580

ttctttcttt ctttctttct tccttcctga aagtgaatgt ataaagcctt tacaatgtat   2640

aactgttgga aaatgcccac cactaaattt ttttttaagt tccacatatt ctccattttt   2700

gccttcttat atatatcttc aacactattc tgtgcacttt aaaaacttaa cataaacgca   2760

gtgtgacttc tcccatatgc tgggtcccga gactctcaac ttcttaaaaa cctaatggca   2820

tcttgtgact cctagaagta gacataagtc tttcaacctt cacacctact ctttctgttt   2880

taattattat tgctatttgt cttattgttt gtgctttaca agcgttcttg aggacggagg   2940

gaatctacga ccctgttgat gactgtaact ctattcgact ttgagttgtc ttcttcatgt   3000

cttgttatat agttcatatt catggctgaa acttgaccat actccctagc gctgattgta   3060

tggttttcgt ctggacaccg tacactgcct gataacttgt gcacctctta acgctactat   3120

gctctgggct ggagaatgaa atctttaagt caccaggact tgctgtttca gtggcttgac   3180

acctgggcca ccaaagaact cgatcttcat cttttaggga cacctctgct gcaccttgga   3240

aagccaacct taagtgccag tggcacttta tgcccagctt tgctttgaaa gatatctttc   3300

ttgttttttt tatccttctc tttctctctt ttttttaaaa atacacatag tcaataggtc   3360

cagtctgccc tcaaggcctt gctgggtttt cttcatcatc caatcacttt cattaaaaat   3420

ggctgcagct gtaagaactc ttgtctgata aattttcaac tatgctctca tttatctacc   3480

tgccctctga tgctcagtcg tcagactcta atgcaaaggt ggacgtcggc tgcctttgcg   3540

tgggcgggct tagtggtgag gaactgatat cagaaaaaaa atgccttcaa gtatactaat   3600

ttattaataa atattaggtg tttgtt                                        3626


<210>  4
<211>  655
<212>  PRT
<213>  Mus musculus

<400>  4

Met Gly Thr Arg Ala Ser Ser Ile Thr Ala Leu Ala Ser Cys Ser Arg 
1               5                   10                  15      


Thr Ala Gly Gln Val Gly Ala Thr Met Val Ala Gly Ser Leu Leu Leu 
            20                  25                  30          


Leu Gly Phe Leu Ser Thr Ile Thr Ala Gln Pro Glu Gln Lys Thr Leu 
        35                  40                  45              


Ser Leu Pro Gly Thr Tyr Arg His Val Asp Arg Thr Thr Gly Gln Val 
    50                  55                  60                  


Leu Thr Cys Asp Lys Cys Pro Ala Gly Thr Tyr Val Ser Glu His Cys 
65                  70                  75                  80  


Thr Asn Met Ser Leu Arg Val Cys Ser Ser Cys Pro Ala Gly Thr Phe 
                85                  90                  95      


Thr Arg His Glu Asn Gly Ile Glu Arg Cys His Asp Cys Ser Gln Pro 
            100                 105                 110         


Cys Pro Trp Pro Met Ile Glu Arg Leu Pro Cys Ala Ala Leu Thr Asp 
        115                 120                 125             


Arg Glu Cys Ile Cys Pro Pro Gly Met Tyr Gln Ser Asn Gly Thr Cys 
    130                 135                 140                 


Ala Pro His Thr Val Cys Pro Val Gly Trp Gly Val Arg Lys Lys Gly 
145                 150                 155                 160 


Thr Glu Asn Glu Asp Val Arg Cys Lys Gln Cys Ala Arg Gly Thr Phe 
                165                 170                 175     


Ser Asp Val Pro Ser Ser Val Met Lys Cys Lys Ala His Thr Asp Cys 
            180                 185                 190         


Leu Gly Gln Asn Leu Glu Val Val Lys Pro Gly Thr Lys Glu Thr Asp 
        195                 200                 205             


Asn Val Cys Gly Met Arg Leu Phe Phe Ser Ser Thr Asn Pro Pro Ser 
    210                 215                 220                 


Ser Gly Thr Val Thr Phe Ser His Pro Glu His Met Glu Ser His Asp 
225                 230                 235                 240 


Val Pro Ser Ser Thr Tyr Glu Pro Gln Gly Met Asn Ser Thr Asp Ser 
                245                 250                 255     


Asn Ser Thr Ala Ser Val Arg Thr Lys Val Pro Ser Gly Ile Glu Glu 
            260                 265                 270         


Gly Thr Val Pro Asp Asn Thr Ser Ser Thr Ser Gly Lys Glu Gly Thr 
        275                 280                 285             


Asn Arg Thr Leu Pro Asn Pro Pro Gln Val Thr His Gln Gln Ala Pro 
    290                 295                 300                 


His His Arg His Ile Leu Lys Leu Leu Pro Ser Ser Met Glu Ala Thr 
305                 310                 315                 320 


Gly Glu Lys Ser Ser Thr Ala Ile Lys Ala Pro Lys Arg Gly His Pro 
                325                 330                 335     


Arg Gln Asn Ala His Lys His Phe Asp Ile Asn Glu His Leu Pro Trp 
            340                 345                 350         


Met Ile Val Leu Phe Leu Leu Leu Val Leu Val Leu Ile Val Val Cys 
        355                 360                 365             


Ser Ile Arg Lys Ser Ser Arg Thr Leu Lys Lys Gly Pro Arg Gln Asp 
    370                 375                 380                 


Pro Ser Ala Ile Val Glu Lys Ala Gly Leu Lys Lys Ser Leu Thr Pro 
385                 390                 395                 400 


Thr Gln Asn Arg Glu Lys Trp Ile Tyr Tyr Arg Asn Gly His Gly Ile 
                405                 410                 415     


Asp Ile Leu Lys Leu Val Ala Ala Gln Val Gly Ser Gln Trp Lys Asp 
            420                 425                 430         


Ile Tyr Gln Phe Leu Cys Asn Ala Ser Glu Arg Glu Val Ala Ala Phe 
        435                 440                 445             


Ser Asn Gly Tyr Thr Ala Asp His Glu Arg Ala Tyr Ala Ala Leu Gln 
    450                 455                 460                 


His Trp Thr Ile Arg Gly Pro Glu Ala Ser Leu Ala Gln Leu Ile Ser 
465                 470                 475                 480 


Ala Leu Arg Gln His Arg Arg Asn Asp Val Val Glu Lys Ile Arg Gly 
                485                 490                 495     


Leu Met Glu Asp Thr Thr Gln Leu Glu Thr Asp Lys Leu Ala Leu Pro 
            500                 505                 510         


Met Ser Pro Ser Pro Leu Ser Pro Ser Pro Met Pro Ser Pro Asn Val 
        515                 520                 525             


Lys Leu Glu Asn Ser Thr Leu Leu Thr Val Glu Pro Ser Pro Leu Asp 
    530                 535                 540                 


Lys Asn Lys Cys Phe Phe Val Asp Glu Ser Glu Pro Leu Leu Arg Cys 
545                 550                 555                 560 


Asp Ser Thr Ser Ser Gly Ser Ser Ala Leu Ser Arg Asn Gly Ser Phe 
                565                 570                 575     


Ile Thr Lys Glu Lys Lys Asp Thr Val Leu Arg Gln Val Arg Leu Asp 
            580                 585                 590         


Pro Cys Asp Leu Gln Pro Ile Phe Asp Asp Met Leu His Ile Leu Asn 
        595                 600                 605             


Pro Glu Glu Leu Arg Val Ile Glu Glu Ile Pro Gln Ala Glu Asp Lys 
    610                 615                 620                 


Leu Asp Arg Leu Phe Glu Ile Ile Gly Val Lys Ser Gln Glu Ala Ser 
625                 630                 635                 640 


Gln Thr Leu Leu Asp Ser Val Tyr Ser His Leu Pro Asp Leu Leu 
                645                 650                 655 


<210>  5
<211>  8
<212>  PRT
<213>  Artificial sequence


<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  Xaa can be lysine, arginine, histidine, glutamine or asparagine

<400>  167

Cys Leu Ser Pro Xaa Xaa Xaa Cys 
1               5                         


<210>  6
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M50-H01 variable heavy chain

<400>  6
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct gattacccta tgatgtgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttctcgt atctctcctt ctggtggcca tactatttat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gaaagattgg    300

cacggtggtg gtgcttttga tatctggggc caagggacaa tggtcaccgt ctcaagc       357


<210>  7
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  M50-H01 variable heavy chain

<400>  7

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Pro Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Ser Pro Ser Gly Gly His Thr Ile Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Trp His Gly Gly Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  8
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M50-H01 VH CDR1

<400>  8

Asp Tyr Pro Met Met 
1               5   


<210>  9
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  M50-H01 VH CDR2

<400>  9

Arg Ile Ser Pro Ser Gly Gly His Thr Ile Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M50-H01  VH CDR3

<400>  10

Asp Trp His Gly Gly Gly Ala Phe Asp Ile 
1               5                   10  


<210>  11
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M50-H01 variable light chain

<400>  11
gacatccaga tgacccagtc tccatcctct gtgtctgcat ctgtaggaga cagagtcacc     60

atcacttgtc gggcgagtca gggtattaga agctggttag cctggtatca gcagaaacca    120

gggaaagccc ctaaactcct gatctatgat gcatccactt tgcaaagtgg ggtcccatca    180

aggttcaggg gcggtggctc tgggacagat ttcactctca ctatcagcag cctgcagcct    240

gaagattttg caacttacta ctgtcaacag agttacagta ccccgctcac tttcggcgga    300

gggaccaagg tggagatcaa a                                              321


<210>  12
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  M50-H01 variable light chain

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M50-H01 VL CDR1

<400>  13

Arg Ala Ser Gln Gly Ile Arg Ser Trp Leu Ala 
1               5                   10      


<210>  14
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  M50-H01 VL CDR2

<400>  14

Asp Ala Ser Thr Leu Gln Ser 
1               5           


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M50-H01 VL CDR3

<400>  15

Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  16
<211>  351
<212>  DNA
<213>  Artificial sequence

<220>
<223>  M51-H09 variable heavy chain 

<400>  16
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct ccttactcta tgacttgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttcttct atcgttcctt ctggtggcaa gacttggtat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gaggaccaat    300

cttagctact ttgactactg gggccagggc accctggtca ccgtctcaag c             351


<210>  17
<211>  117
<212>  PRT
<213>  Artificial sequence

<220>
<223>  M51-H09 variable heavy chain 

<400>  17

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Pro Tyr 
            20                  25                  30          


Ser Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Val Pro Ser Gly Gly Lys Thr Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Asn Leu Ser Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  18
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M51-H09 VH CDR1

<400>  18

Pro Tyr Ser Met Thr 
1               5   


<210>  19
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M51-H09 VH CDR2

<400>  19

Ser Ile Val Pro Ser Gly Gly Lys Thr Trp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M51-H09 VH CDR3

<400>  20

Thr Asn Leu Ser Tyr Phe Asp Tyr 
1               5               


<210>  21
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M51-H09 variable light chain

<400>  21
cagagcgaat tgactcagcc tccctccgcg tccgggtctc ctggacagtc agtcaccatc     60

tcctgcactg gaaccagcaa tgacgttggt agttataact atatctcctg gttccaacag    120

cacccaggca aagcccccaa actcatgatt tatgaggtca ataagcggcc ctcaggggtc    180

cctgatcgct tctctggctc caagtctgac aacacggcct ccctgaccgt ctctgggctc    240

caggctgaag atgaggctga ttattactgc acctcatatg caggcagcca caagtgggtg    300

ttcggcggag ggaccaagct gaccgtccta                                     330


<210>  22
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M51-H09 variable light chain

<400>  22

Gln Ser Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Asn Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Tyr Ile Ser Trp Phe Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Asp Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Thr Ser Tyr Ala Gly Ser 
                85                  90                  95      


His Lys Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  23
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M51-H09 VL CDR1

<400>  23

Thr Gly Thr Ser Asn Asp Val Gly Ser Tyr Asn Tyr Ile Ser 
1               5                   10                  


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M51-H09 VL CDR2

<400>  24

Glu Val Asn Lys Arg Pro Ser 
1               5           


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M51-H09 VL CDR3

<400>  25

Thr Ser Tyr Ala Gly Ser His Lys Trp Val 
1               5                   10  


<210>  26
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M53-E04 variable heavy chain

<400>  26
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct aattacgaga tgtcttgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttcttct atctattctt ctggtggcga gactctttat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagagatgga    300

gcagctgact actggggcca gggcaccctg gtcaccgtct caagc                    345


<210>  27
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M53-E04 variable heavy chain

<400>  27

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Tyr Ser Ser Gly Gly Glu Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ala Ala Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  28
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M53-E04 VH CDR1

<400>  28

Asn Tyr Glu Met Ser 
1               5   


<210>  29
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M53-E04 VH CDR2

<400>  29

Ser Ile Tyr Ser Ser Gly Gly Glu Thr Leu Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  30
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M53-E04 VH CDR3

<400>  30

Asp Gly Ala Ala Asp Tyr 
1               5       


<210>  31
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M53-E04 variable light chain

<400>  31
cagagcgaat tgactcagcc accctcggcg tctgggaccc ccgggcagtg ggtcaccatc     60

tcttgttctg gaagcacctc caacatcgga aataattatg tatactggta ccagcagctc    120

ccaggaacgg cccccaagct cctcatctat acgaataatc agcggccctc aggggtccct    180

gaccgattct ctggctccaa gtctggcacg tccgcctccc tggccatcag tgggctccgg    240

tccgaggatg aggctgatta ttactgtgcg acatgggatg acagtttgta tgctccggta    300

ttcggcggag ggaccaaggt gaccgtccta                                     330


<210>  32
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M53-E04 variable light chain

<400>  32

Gln Ser Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Trp Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Thr Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 
                85                  90                  95      


Tyr Ala Pro Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  33
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M53-E04 VL CDR1

<400>  33

Ser Gly Ser Thr Ser Asn Ile Gly Asn Asn Tyr Val Tyr 
1               5                   10              


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M53-E04 VL CDR2

<400>  34

Thr Asn Asn Gln Arg Pro Ser 
1               5           


<210>  35
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M53-E04 VL CDR3

<400>  35

Ala Thr Trp Asp Asp Ser Leu Tyr Ala Pro Val 
1               5                   10      


<210>  36
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M53-F04 variable heavy chain

<400>  36
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct gagtacacta tgcattgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttctgtt atctcttctt ctggtggccg tactgtttat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagagatctg    300

agtaactaca tggactactg gggccagggc accctggtca ccgtctcaag c             351


<210>  37
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M53-F04 variable heavy chain

<400>  37

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Ser Ser Gly Gly Arg Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Ser Asn Tyr Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  38
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M53-F04 VH CDR1

<400>  38

Glu Tyr Thr Met His 
1               5   


<210>  39
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M53-F04 VH CDR2

<400>  39

Val Ile Ser Ser Ser Gly Gly Arg Thr Val Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M53-F04 VH CDR3

<400>  40

Asp Leu Ser Asn Tyr Met Asp Tyr 
1               5               


<210>  41
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M53-F04 variable light chain

<400>  41
gacatccaga tgacccagtc tccagccacc ctgtctttgt ctccagggga aagagccacc     60

ctctcctgca gggccagtca gactgttagc aactacttag cctggtacca acagaaacct    120

ggccaggctc ccaggctcct catctatgat gcctccaaca gggccactgg catcccagcc    180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct    240

gaagattttg cagtttatta ctgtcagcag cgtagcaagt ggctctcttt cggcggaggg    300

accaaggtgg agatcaaa                                                  318


<210>  42
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M53-F04 variable light chain

<400>  42

Asp Ile Gln Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Val Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Lys Trp Leu Ser 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  43
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M53-F04 VL CDR1

<400>  43

Arg Ala Ser Gln Thr Val Ser Asn Tyr Leu Ala 
1               5                   10      


<210>  44
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M53-F04 VL CDR2

<400>  44

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  45
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M53-F04 VL CDR3

<400>  45

Gln Gln Arg Ser Lys Trp Leu Ser 
1               5               


<210>  46
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M62-B02 variable heavy chain

<400>  46
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct atgtacatta tgaattgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttcttct atcgtttctt ctggtggctg gactttttat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gaggggccac    300

tacggtatgg acgtctgggg ccaagggacc acggtcaccg tctcaagc                 348


<210>  47
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M62-B02 variable heavy chain

<400>  47

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Met Tyr 
            20                  25                  30          


Ile Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Val Ser Ser Gly Gly Trp Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  48
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M62-B02 VH CDR1

<400>  48

Met Tyr Ile Met Asn 
1               5   


<210>  49
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M62-B02 VH CDR2

<400>  49

Ser Ile Val Ser Ser Gly Gly Trp Thr Phe Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M62-B02 VH CDR3

<400>  50

Gly His Tyr Gly Met Asp Val 
1               5           


<210>  51
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M62-B02 variable light chain

<400>  51
gacatccaga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc     60

atcaactgca agtccagccg gagtgtttta tacagctcca acaataagaa ctacttagct    120

tggtaccagc agaaaccagg acagcctcct aagctgctca tttactgggc ttctacccgg    180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc    240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttatagtact    300

cctctcactt tcggcggagg gaccaaggtg gagatcaaa                           339


<210>  52
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M62-B02 variable light chain

<400>  52

Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Arg Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  53
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M62-B02 VL CDR1

<400>  53

Lys Ser Ser Arg Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  54
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M62-B02 VL CDR2

<400>  54

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  55
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M62-B02 VL CDR3

<400>  55

Gln Gln Tyr Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  56
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M63-E10 variable heavy chain

<400>  56
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct cagtacaaga tgtcttgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttcttct atctcttctt ctggtggcac taattatgct    180

gactccgtta aaggtcgctt cactatctct agagacaact ctaagaatac tctctacttg    240

cagatgaaca gcttaagggc tgaggacacc gccatgtatt actgtgcgag acggaactac    300

ggtgacagac cttactggta cttcgatctc tggggccgtg gcaccctggt caccgtctca    360

agc                                                                  363


<210>  57
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M63-E10 variable heavy chain

<400>  57

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gln Tyr 
            20                  25                  30          


Lys Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Gly Gly Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Arg Asn Tyr Gly Asp Arg Pro Tyr Trp Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  58
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M63-E10 VH CDR1

<400>  58

Gln Tyr Lys Met Ser 
1               5   


<210>  59
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M63-E10 VH CDR2

<400>  59

Ser Ile Ser Ser Ser Gly Gly Thr Asn Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  60
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M63-E10 VH CDR3

<400>  60

Arg Asn Tyr Gly Asp Arg Pro Tyr Trp Tyr Phe Asp Leu 
1               5                   10              


<210>  61
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M63-E10 variable light chain

<400>  61
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggccagtca gactattagt agatggttgg cctggtatca gcacaaacca    120

gggaaagccc ctaaactcct gatctacaag acgtctaatt tagaaagtgg ggtcccatca    180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagtag cctgcagcct    240

gatgattttg ccacttatta ctgccaacag tataaaagtt attcgatcac cttcggccct    300

gggaccaaag tggatatcaa a                                              321


<210>  62
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M63-E10 variable light chain

<400>  62

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Ser Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Thr Ser Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Lys Ser Tyr Ser Ile 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  63
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M63-E10 VL CDR1

<400>  63

Arg Ala Ser Gln Thr Ile Ser Arg Trp Leu Ala 
1               5                   10      


<210>  64
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M63-E10 VL CDR2

<400>  64

Lys Thr Ser Asn Leu Glu Ser 
1               5           


<210>  65
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M63-E10 VL CDR3

<400>  65

Gln Gln Tyr Lys Ser Tyr Ser Ile Thr 
1               5                   


<210>  66
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M66-B03 variable heavy chain

<400>  66
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct ccttactgga tgtcttgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttctgtt atctatcctt ctggtggcca tacttattat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gaggccaggg    300

ttcggggcgg cttttgacta ctggggcccg ggaaccctgg tcaccgtctc aagc          354


<210>  67
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M66-B03 variable heavy chain

<400>  67

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Pro Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Pro Ser Gly Gly His Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Gly Phe Gly Ala Ala Phe Asp Tyr Trp Gly Pro Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  68
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M66-B03 VH CDR1

<400>  68

Pro Tyr Trp Met Ser 
1               5   


<210>  69
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M66-B03 VH CDR2

<400>  69

Val Ile Tyr Pro Ser Gly Gly His Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  70
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M66-B03 VH CDR3

<400>  70

Pro Gly Phe Gly Ala Ala Phe Asp Tyr 
1               5                   


<210>  71
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M66-B03 variable light chain

<400>  71
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc     60

atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagaaacca    120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca    180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct    240

gaagattttg caacttacta ttgtcaacag gctaacagtt tccccctcac tttcggcgga    300

gggaccaagg tggagatcaa a                                              321


<210>  72
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M66-B03 variable light chain

<400>  72

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  73
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M66-B03 VL CDR1

<400>  73

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  74
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M66-B03 VL CDR2

<400>  74

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  75
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M66-B03 VL CDR3

<400>  75

Gln Gln Ala Asn Ser Phe Pro Leu Thr 
1               5                   


<210>  76
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M67-G02 variable heavy chain

<400>  76
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct cgttactcta tgcagtgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttctgtt atctctcctt ctggtggctc tactatgtat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagagaatca    300

tatagcagca gctggtattc tgggtactac tactactacg gtatggacgt ctggggccaa    360

gggaccacgg tcaccgtctc aagc                                           384


<210>  77
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M67-G02 variable heavy chain

<400>  77

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Ser Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Pro Ser Gly Gly Ser Thr Met Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ser Tyr Ser Ser Ser Trp Tyr Ser Gly Tyr Tyr Tyr Tyr 
            100                 105                 110         


Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             


<210>  78
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M67-G02 VH CDR1

<400>  78

Arg Tyr Ser Met Gln 
1               5   


<210>  79
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M67-G02 VH CDR2

<400>  79

Val Ile Ser Pro Ser Gly Gly Ser Thr Met Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  80
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M67-G02 VH CDR3

<400>  80

Glu Ser Tyr Ser Ser Ser Trp Tyr Ser Gly Tyr Tyr Tyr Tyr Tyr Gly 
1               5                   10                  15      


Met Asp Val 
            


<210>  81
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M67-G02 variable light chain

<400>  81
gacatccaga tgacccagtc tccagcctcc ctgtctgcat ctgttggaga cagagtcacc     60

atcacttgcc gggcaagtca gaccattgcc ggctatttaa attggtatca gcagacacca    120

gggaaagccc ctaatctcct gatctatgat gcatcccgtt tgcaaagtgg ggtcccatca    180

cggttcagtg gcagtggatc tgggacagat ttcactctca gcatcagcgg tctgcaacct    240

gaagattttg gaacttacta ctgtcaacag agttacacca tcccgctcac tttcggcgga    300

gggaccaagg tggagatcaa a                                              321


<210>  82
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M67-G02 variable light chain

<400>  82

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Ala Gly Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Asn Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Gly Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln Gln Ser Tyr Thr Ile Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  83
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M67-G02 VL CDR1

<400>  83

Arg Ala Ser Gln Thr Ile Ala Gly Tyr Leu Asn 
1               5                   10      


<210>  84
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M67-G02 VL CDR2

<400>  84

Asp Ala Ser Arg Leu Gln Ser 
1               5           


<210>  85
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M67-G02 VL CDR3

<400>  85

Gln Gln Ser Tyr Thr Ile Pro Leu Thr 
1               5                   


<210>  86
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M72-F03 variable heavy chain

<400>  86
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct cagtacatga tgtcttgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttctgtt atctatcctt ctggtggctc tactcattat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagaggccac    300

tacggtatgg acgtctgggg ccaggggacc acggtcaccg tctcaagc                 348


<210>  87
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M72-F03 variable heavy chain

<400>  87

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gln Tyr 
            20                  25                  30          


Met Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Pro Ser Gly Gly Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly His Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  88
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M72-F03 VH CDR1

<400>  88

Gln Tyr Met Met Ser 
1               5   


<210>  89
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M72-F03 VH CDR2

<400>  89

Val Ile Tyr Pro Ser Gly Gly Ser Thr His Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly Arg
    


<210>  90
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M72-F03 VH CDR3

<400>  90

Gly His Tyr Gly Met Asp Val 
1               5           


<210>  91
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M72-F03 variable light chain

<400>  91
gacatccaga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc     60

atcaactgca agtccagcca gagtgtttta tacagctcca acaataagaa ctacttagct    120

tggtatcagc ataaagcagg acagcctcct aagctgctca ttcactgggc atcttcccgg    180

gcatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc    240

atcagcagcc tgcaggctga ggatgtggcc gtctattact gtcagcaatt ttacagtctt    300

cctctcactt tcggcggagg gaccaaggtg gagatcaga                           339


<210>  92
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M72-F03 variable light chain

<400>  92

Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln His Lys Ala Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile His Trp Ala Ser Ser Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Phe Tyr Ser Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Arg 
    


<210>  93
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M72-F03 VL CDR1

<400>  93

Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  94
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M72-F03 VL CDR2

<400>  94

Trp Ala Ser Ser Arg Ala Ser 
1               5           


<210>  95
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M72-F03 VL CDR3

<400>  95

Gln Gln Phe Tyr Ser Leu Pro Leu Thr 
1               5                   


<210>  96
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M73-C04 variable heavy chain

<400>  96
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt     60

tcttgcgctg cttccggatt cactttctct ccttacgcta tggtttgggt tcgccaagct    120

cctggtaaag gtttggagtg ggtttcttct atctctcctt ctggtggcgg tactggttat    180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac    240

ttgcagatga acagcttaag ggctgaggac acggccgtgt attactgtgc gagagagggg    300

tggaactact actacggtat ggacgtctgg ggccaaggga ccacggtcac cgtctcaagc    360


<210>  97
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M73-C04 variable heavy chain

<400>  97

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Pro Tyr 
            20                  25                  30          


Ala Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Pro Ser Gly Gly Gly Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Trp Asn Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  98
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M73-C04 VH CDR1

<400>  98

Pro Tyr Ala Met Val 
1               5   


<210>  99
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M73-C04 VH CDR2

<400>  99

Ser Ile Ser Pro Ser Gly Gly Gly Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  100
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M73-C04 VH CDR3

<400>  100

Glu Gly Trp Asn Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10      


<210>  101
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  M73-C04 variable light chain

<400>  101
gacatccaga tgacccagtc tccagccacc ctgtctttgt ctccagggga aagagccacc     60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct    120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc    180

aggttcagtg gcagtgggtc tggcacagat ttcactctcg ccatcagcag cctgcagcct    240

gaagattctg caacttatta ctgtctacaa gatttcattt acccgtacac ttttggccag    300

gggaccaagc tggagatcag a                                              321


<210>  102
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M73-C04 variable light chain

<400>  102

Asp Ile Gln Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ala Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ser Ala Thr Tyr Tyr Cys Leu Gln Asp Phe Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Arg 
            100                 105         


<210>  103
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M73-C04 VL CDR1

<400>  103

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  104
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M73-C04 VL CDR2

<400>  104

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  105
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M73-C04 VL CDR3

<400>  105

Leu Gln Asp Phe Ile Tyr Pro Tyr Thr 
1               5                   


<210>  106
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1P1D6.3 variable heavy chain

<400>  106
caggttcagc tgcagcagtc tggaactgag ctggcgaggc ccggggcttc agtgaagctg     60

tcctgcaagg cttctggcta caccttcact gactactatc taaactggat gaaacagggg    120

actggacagg gccttgagtg gattggagag atttatcctg gaggtgatca cacttactac    180

aatgagaaat tcaagggcaa ggccacactg actgcagaca aatcctccaa cacagccttc    240

atgcagctca gcagcctgac atctgaggac tctgcagtct atttctgtac aagaggggtg    300

attaagtggg gccaagggac tctggtcact gtctcttta                           339


<210>  107
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1P1D6.3 variable heavy chain

<400>  107

Gln Val Gln Leu Gln Gln Ser Gly Thr Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Leu Asn Trp Met Lys Gln Gly Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Gly Gly Asp His Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Phe 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Gly Val Ile Lys Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Leu 
    


<210>  108
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1P1D6.3 VH CDR1

<400>  108

Asp Tyr Tyr Leu Asn 
1               5   


<210>  109
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1P1D6.3 VH CDR2

<400>  109

Glu Ile Tyr Pro Gly Gly Asp His Thr Tyr Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  110
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1P1D6.3 VH CDR3

<400>  110

Gly Val Ile Lys 
1               


<210>  111
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1P1D6.3 variable light chain

<400>  111
gacatcctga tgacccaatc tccaccctcc atgtctgtct ctctgggaga cacagtcagc     60

atcacttgcc atgcaagtca gggcattagc agtaatatag ggtggttgca gcagaaacca    120

gggaaatcat ttaagggcct gatctatcat ggatccacct tggaggatgg agttccatca    180

agattcagtg gcagtggatc tggagcagaa ttttctctca ccatcagcag cctggaatct    240

gaagattttg cagactatta ctgtgttcaa tatgctcagt ttccttacac gttcggaggg    300

gggaccaagc tagaaataaa a                                              321


<210>  112
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1P1D6.3 variable light chain

<400>  112

Asp Ile Leu Met Thr Gln Ser Pro Pro Ser Met Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Thr Val Ser Ile Thr Cys His Ala Ser Gln Gly Ile Ser Ser Asn 
            20                  25                  30          


Ile Gly Trp Leu Gln Gln Lys Pro Gly Lys Ser Phe Lys Gly Leu Ile 
        35                  40                  45              


Tyr His Gly Ser Thr Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Glu Phe Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Ala Gln Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  113
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1P1D6.3 VL CDR1

<400>  113

His Ala Ser Gln Gly Ile Ser Ser Asn Ile Gly 
1               5                   10      


<210>  114
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1P1D6.3 VL CDR2

<400>  114

His Gly Ser Thr Leu Glu Asp 
1               5           


<210>  115
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1P1D6.3 VL CDR3

<400>  115

Val Gln Tyr Ala Gln Phe Pro Tyr Thr 
1               5                   


<210>  116
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1P2F2.1 variable heavy chain

<400>  116
caggttcagc tgcagcagtc tggacctgag gtggcgaggc ccggggcttc agtgaagctg     60

tcctgcaagg cttctggcta caccttcact gactactatt taaactgggt gaagcagagg    120

actggacagg gccttgagtg gattggagag atttatcctg gaaataatca tacttactac    180

aatgagaagt tcaagggcaa ggccacactg actgcagaca attcctccag cacagcctac    240

ttgcagttca gcagcctgac atctgaggac tctgctgtct atttctgtac aagaggggtg    300

attaagtggg gccaagggac tctggtcact gtctctgta                           339


<210>  117
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1P2F2.1 variable heavy chain

<400>  117

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Leu Asn Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Pro Gly Asn Asn His Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Asn Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Gly Val Ile Lys Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Val 
    


<210>  118
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1P2F2.1 VH CDR1

<400>  118

Asp Tyr Tyr Leu Asn 
1               5   


<210>  119
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1P2F2.1 VH CDR2

<400>  119

Glu Ile Tyr Pro Gly Asn Asn His Thr Tyr Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  120
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1P2F2.1 VH CDR3

<400>  120

Gly Val Ile Lys 
1               


<210>  121
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1P2F2.1 variable light chain

<400>  121
gacatcctga tgacccaatc tccatcctcc atgtctgtat ctctgggaga cacagtcagc     60

atcacttgcc atgccagtca gggcattagg aatagtatag ggtggttgca gcagaaacca    120

gggaaatcat ttaagggcct gatctatcat gcaaccacct tggaagatgg agttccatca    180

aggttcactg gcagtggatc tggagcagat ttttctctca ccatcagcag cctggaatct    240

gaagattttg cagactatta ctgtgtacag tacgctcagt ttccttacac gttcggaggg    300

gggaccaagc tggaaataaa a                                              321


<210>  122
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1P2F2.1 variable light chain

<400>  122

Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Thr Val Ser Ile Thr Cys His Ala Ser Gln Gly Ile Arg Asn Ser 
            20                  25                  30          


Ile Gly Trp Leu Gln Gln Lys Pro Gly Lys Ser Phe Lys Gly Leu Ile 
        35                  40                  45              


Tyr His Ala Thr Thr Leu Glu Asp Gly Val Pro Ser Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ala Asp Phe Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Ala Gln Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  123
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1P2F2.1 VL CDR1

<400>  123

His Ala Ser Gln Gly Ile Arg Asn Ser Ile Gly 
1               5                   10      


<210>  124
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1P2F2.1 VL CDR2

<400>  124

His Ala Thr Thr Leu Glu Asp 
1               5           


<210>  125
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1P2F2.1 VL CDR3

<400>  125

Val Gln Tyr Ala Gln Phe Pro Tyr Thr 
1               5                   


<210>  126
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1P5D10.2 variable heavy chain

<400>  126
gaagtgcagc tggtggagtc ggggggaggc ttagtgaagc ctggagggtc cctgaaactc     60

tcctgtgcag cctctggatt cactttcagt gactattaca tgtattgggt tcgccagact    120

ccggaaaaga ggctggagtg ggtcgcaacc attagtgatg gtggtcttta cacctactat    180

caagacagtg tgaaggggcg attcaccatc tccagagaca atgccaagaa caacctgtac    240

ctgcaaatga gcagtctgaa gtctgaggac acagccatgt attactgtgc aagagaagat    300

gattacgacg gggatttcta tactatggac tactggggtc aaggaacctc agtcaccgtc    360

tcctca                                                               366


<210>  127
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1P5D10.2 variable heavy chain

<400>  127

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Asp Gly Gly Leu Tyr Thr Tyr Tyr Gln Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Asp Tyr Asp Gly Asp Phe Tyr Thr Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  128
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1P5D10.2 VH CDR1

<400>  128

Asp Tyr Tyr Met Tyr 
1               5   


<210>  129
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1P5D10.2 VH CDR2

<400>  129

Thr Ile Ser Asp Gly Gly Leu Tyr Thr Tyr Tyr Gln Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  130
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1P5D10.2 VH CDR3

<400>  130

Glu Asp Asp Tyr Asp Gly Asp Phe Tyr Thr Met Asp Tyr 
1               5                   10              


<210>  131
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1P5D10.2 variable light chain

<400>  131
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc     60

ataacctgca gtgccagctc aagtgtaagt tacatgcact ggttccagca gaagccaggc    120

acttctccca aactctggat ttatagcaca tccaacctgg cttctggagt ccctgctcgc    180

ttcagtggca gtggatctgg gacctcttac tctctcacaa tcagccgaat ggaggctgaa    240

gatgctgcca cttattactg ccagcaaagg agtagttacc cactcacgtt cggtgctggg    300

accaagctgg agctgaaa                                                  318


<210>  132
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1P5D10.2 variable light chain

<400>  132

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  133
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1P5D10.2 VL CDR1

<400>  133

Ser Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  134
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1P5D10.2 VL CDR2

<400>  134

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  135
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1P5D10.2 VL CDR3

<400>  135

Gln Gln Arg Ser Ser Tyr Pro Leu Thr
1               5               


<210>  136
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  flexible sequence linker

<400>  136

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15


<210>  137
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  flexible linker sequence

<400>  137

Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser 
1               5                   10  


<210>  138
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  flexible linker sequence

<400>  138

Glu Ser Gly Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  139
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  flexible linker sequence

<400>  139

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr 
1               5                   10                  


<210>  140
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  flexible linker sequence

<400>  140

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Gln 
1               5                   10                  15  


<210>  141
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  flexible linker sequence

<400>  141

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Val Asp 
1               5                   10                  


<210>  142
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  flexible linker sequence

<400>  142

Gly Ser Thr Ser Gly Ser Gly Lys Ser Ser Glu Gly Lys Gly 
1               5                   10                  


<210>  143
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  flexible linker sequence

<400>  143

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  144
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  flexible linker sequence

<400>  144

Glu Ser Gly Ser Val Ser Ser Glu Glu Leu Ala Phe Arg Ser Leu Asp 
1               5                   10                  15      


<210>  145
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  flag peptide

<400>  145

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  146
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  flag peptide

<400>  146

Asp Tyr Lys Asp Glu Asp Asp Lys 
1               5               


<210>  147
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  strep epitope

<400>  147

Ala Trp Arg His Pro Gln Phe Gly Gly 
1               5                   


<210>  148
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VSV-G epitope

<400>  148

Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
1               5                   10      


<210>  149
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Poly-His tag

<400>  149

His His His His His His 
1               5       


<210>  150
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA epitope

<400>  150

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ile Glu Gly Arg 
1               5                   10              


<210>  151
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-MYC epitope

<400>  151

Glu Gln Lys Leu Leu Ser Glu Glu Asp Leu Asn 
1               5                   10      


<210>  152
<211>  200
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(200)
<223>  n is a, c, g, t, or u

<220>
<221>  misc_feature
<222>  (2)..(200)
<223>  nucleotide may be missing

<400>  152

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     60

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    120

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    180

nnnnnnnnnn nnnnnnnnnn                                                200


<210>  153
<211>  200
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<220>
<221>  misc_feature
<222>  (1)..(200)
<223>  n is a, c, g, t, or u

<220>
<221>  misc_feature
<222>  (2)..(200)
<223>  nucleotide may be missing

<400>  153

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     60

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    120

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    180

nnnnnnnnnn nnnnnnnnnn                                                200


<210>  154
<211>  1998
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human DR6 with Myc tag

<400>  154
atggggacct ctccgagcag cagcaccgcc ctcgcctcct gcagccgcat cgcccgccga     60

gccacagcca cgatgatcgc gggctccctt ctcctgcttg gattccttag caccaccaca    120

gctgagcaga agctgatctc agaggaggac ctgcagccag aacagaaggc ctcgaatctc    180

attggcacat accgccatgt tgaccgtgcc accggccagg tgctaacctg tgacaagtgt    240

ccagcaggaa cctatgtctc tgagcattgt accaacacaa gcctgcgcgt ctgcagcagt    300

tgccctgtgg ggacctttac caggcatgag aatggcatag agaaatgcca tgactgtagt    360

cagccatgcc catggccaat gattgagaaa ttaccttgtg ctgccttgac tgaccgagaa    420

tgcacttgcc cacctggcat gttccagtct aacgctacct gtgcccccca tacggtgtgt    480

cctgtgggtt ggggtgtgcg gaagaaaggg acagagactg aggatgtgcg gtgtaagcag    540

tgtgctcggg gtaccttctc agatgtgcct tctagtgtga tgaaatgcaa agcatacaca    600

gactgtctga gtcagaacct ggtggtgatc aagccgggga ccaaggagac agacaacgtc    660

tgtggcacac tcccgtcctt ctccagctcc acctcacctt cccctggcac agccatcttt    720

ccacgccctg agcacatgga aacccatgaa gtcccttcct ccacttatgt tcccaaaggc    780

atgaactcaa cagaatccaa ctcttctgcc tctgttagac caaaggtact gagtagcatc    840

caggaaggga cagtccctga caacacaagc tcagcaaggg ggaaggaaga cgtgaacaag    900

accctcccaa accttcaggt agtcaaccac cagcaaggcc cccaccacag acacatcctg    960

aagctgctgc cgtccatgga ggccactggg ggcgagaagt ccagcacgcc catcaagggc   1020

cccaagaggg gacatcctag acagaaccta cacaagcatt ttgacatcaa tgagcatttg   1080

ccctggatga ttgtgctttt cctgctgctg gtgcttgtgg tgattgtggt gtgcagtatc   1140

cggaaaagct cgaggactct gaaaaagggg ccccggcagg atcccagtgc cattgtggaa   1200

aaggcagggc tgaagaaatc catgactcca acccagaacc gggagaaatg gatctactac   1260

tgcaatggcc atggtatcga tatcctgaag cttgtagcag cccaagtggg aagccagtgg   1320

aaagatatct atcagtttct ttgcaatgcc agtgagaggg aggttgctgc tttctccaat   1380

gggtacacag ccgaccacga gcgggcctac gcagctctgc agcactggac catccggggc   1440

cccgaggcca gcctcgccca gctaattagc gccctgcgcc agcaccggag aaacgatgtt   1500

gtggagaaga ttcgtgggct gatggaagac accacccagc tggaaactga caaactagct   1560

ctcccgatga gccccagccc gcttagcccg agccccatcc ccagccccaa cgcgaaactt   1620

gagaattccg ctctcctgac ggtggagcct tccccacagg acaagaacaa gggcttcttc   1680

gtggatgagt cggagcccct tctccgctgt gactctacat ccagcggctc ctccgcgctg   1740

agcaggaacg gttcctttat taccaaagaa aagaaggaca cagtgttgcg gcaggtacgc   1800

ctggacccct gtgacttgca gcctatcttt gatgacatgc tccactttct aaatcctgag   1860

gagctgcggg tgattgaaga gattccccag gctgaggaca aactagaccg gctattcgaa   1920

attattggag tcaagagcca ggaagccagc cagaccctcc tggactctgt ttatagccat   1980

cttcctgacc tgctgtag                                                 1998


<210>  155
<211>  665
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human DR6 with Myc tag

<400>  155

Met Gly Thr Ser Pro Ser Ser Ser Thr Ala Leu Ala Ser Cys Ser Arg 
1               5                   10                  15      


Ile Ala Arg Arg Ala Thr Ala Thr Met Ile Ala Gly Ser Leu Leu Leu 
            20                  25                  30          


Leu Gly Phe Leu Ser Thr Thr Thr Ala Glu Gln Lys Leu Ile Ser Glu 
        35                  40                  45              


Glu Asp Leu Gln Pro Glu Gln Lys Ala Ser Asn Leu Ile Gly Thr Tyr 
    50                  55                  60                  


Arg His Val Asp Arg Ala Thr Gly Gln Val Leu Thr Cys Asp Lys Cys 
65                  70                  75                  80  


Pro Ala Gly Thr Tyr Val Ser Glu His Cys Thr Asn Thr Ser Leu Arg 
                85                  90                  95      


Val Cys Ser Ser Cys Pro Val Gly Thr Phe Thr Arg His Glu Asn Gly 
            100                 105                 110         


Ile Glu Lys Cys His Asp Cys Ser Gln Pro Cys Pro Trp Pro Met Ile 
        115                 120                 125             


Glu Lys Leu Pro Cys Ala Ala Leu Thr Asp Arg Glu Cys Thr Cys Pro 
    130                 135                 140                 


Pro Gly Met Phe Gln Ser Asn Ala Thr Cys Ala Pro His Thr Val Cys 
145                 150                 155                 160 


Pro Val Gly Trp Gly Val Arg Lys Lys Gly Thr Glu Thr Glu Asp Val 
                165                 170                 175     


Arg Cys Lys Gln Cys Ala Arg Gly Thr Phe Ser Asp Val Pro Ser Ser 
            180                 185                 190         


Val Met Lys Cys Lys Ala Tyr Thr Asp Cys Leu Ser Gln Asn Leu Val 
        195                 200                 205             


Val Ile Lys Pro Gly Thr Lys Glu Thr Asp Asn Val Cys Gly Thr Leu 
    210                 215                 220                 


Pro Ser Phe Ser Ser Ser Thr Ser Pro Ser Pro Gly Thr Ala Ile Phe 
225                 230                 235                 240 


Pro Arg Pro Glu His Met Glu Thr His Glu Val Pro Ser Ser Thr Tyr 
                245                 250                 255     


Val Pro Lys Gly Met Asn Ser Thr Glu Ser Asn Ser Ser Ala Ser Val 
            260                 265                 270         


Arg Pro Lys Val Leu Ser Ser Ile Gln Glu Gly Thr Val Pro Asp Asn 
        275                 280                 285             


Thr Ser Ser Ala Arg Gly Lys Glu Asp Val Asn Lys Thr Leu Pro Asn 
    290                 295                 300                 


Leu Gln Val Val Asn His Gln Gln Gly Pro His His Arg His Ile Leu 
305                 310                 315                 320 


Lys Leu Leu Pro Ser Met Glu Ala Thr Gly Gly Glu Lys Ser Ser Thr 
                325                 330                 335     


Pro Ile Lys Gly Pro Lys Arg Gly His Pro Arg Gln Asn Leu His Lys 
            340                 345                 350         


His Phe Asp Ile Asn Glu His Leu Pro Trp Met Ile Val Leu Phe Leu 
        355                 360                 365             


Leu Leu Val Leu Val Val Ile Val Val Cys Ser Ile Arg Lys Ser Ser 
    370                 375                 380                 


Arg Thr Leu Lys Lys Gly Pro Arg Gln Asp Pro Ser Ala Ile Val Glu 
385                 390                 395                 400 


Lys Ala Gly Leu Lys Lys Ser Met Thr Pro Thr Gln Asn Arg Glu Lys 
                405                 410                 415     


Trp Ile Tyr Tyr Cys Asn Gly His Gly Ile Asp Ile Leu Lys Leu Val 
            420                 425                 430         


Ala Ala Gln Val Gly Ser Gln Trp Lys Asp Ile Tyr Gln Phe Leu Cys 
        435                 440                 445             


Asn Ala Ser Glu Arg Glu Val Ala Ala Phe Ser Asn Gly Tyr Thr Ala 
    450                 455                 460                 


Asp His Glu Arg Ala Tyr Ala Ala Leu Gln His Trp Thr Ile Arg Gly 
465                 470                 475                 480 


Pro Glu Ala Ser Leu Ala Gln Leu Ile Ser Ala Leu Arg Gln His Arg 
                485                 490                 495     


Arg Asn Asp Val Val Glu Lys Ile Arg Gly Leu Met Glu Asp Thr Thr 
            500                 505                 510         


Gln Leu Glu Thr Asp Lys Leu Ala Leu Pro Met Ser Pro Ser Pro Leu 
        515                 520                 525             


Ser Pro Ser Pro Ile Pro Ser Pro Asn Ala Lys Leu Glu Asn Ser Ala 
    530                 535                 540                 


Leu Leu Thr Val Glu Pro Ser Pro Gln Asp Lys Asn Lys Gly Phe Phe 
545                 550                 555                 560 


Val Asp Glu Ser Glu Pro Leu Leu Arg Cys Asp Ser Thr Ser Ser Gly 
                565                 570                 575     


Ser Ser Ala Leu Ser Arg Asn Gly Ser Phe Ile Thr Lys Glu Lys Lys 
            580                 585                 590         


Asp Thr Val Leu Arg Gln Val Arg Leu Asp Pro Cys Asp Leu Gln Pro 
        595                 600                 605             


Ile Phe Asp Asp Met Leu His Phe Leu Asn Pro Glu Glu Leu Arg Val 
    610                 615                 620                 


Ile Glu Glu Ile Pro Gln Ala Glu Asp Lys Leu Asp Arg Leu Phe Glu 
625                 630                 635                 640 


Ile Ile Gly Val Lys Ser Gln Glu Ala Ser Gln Thr Leu Leu Asp Ser 
                645                 650                 655     


Val Tyr Ser His Leu Pro Asp Leu Leu 
            660                 665 


<210>  156
<211>  1143
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  dominant negative DR6 with Myc tag

<400>  156
atggggacct ctccgagcag cagcaccgcc ctcgcctcct gcagccgcat cgcccgccga     60

gccacagcca cgatgatcgc gggctccctt ctcctgcttg gattccttag caccaccaca    120

gctgagcaga agctgatctc agaggaggac ctgcagccag aacagaaggc ctcgaatctc    180

attggcacat accgccatgt tgaccgtgcc accggccagg tgctaacctg tgacaagtgt    240

ccagcaggaa cctatgtctc tgagcattgt accaacacaa gcctgcgcgt ctgcagcagt    300

tgccctgtgg ggacctttac caggcatgag aatggcatag agaaatgcca tgactgtagt    360

cagccatgcc catggccaat gattgagaaa ttaccttgtg ctgccttgac tgaccgagaa    420

tgcacttgcc cacctggcat gttccagtct aacgctacct gtgcccccca tacggtgtgt    480

cctgtgggtt ggggtgtgcg gaagaaaggg acagagactg aggatgtgcg gtgtaagcag    540

tgtgctcggg gtaccttctc agatgtgcct tctagtgtga tgaaatgcaa agcatacaca    600

gactgtctga gtcagaacct ggtggtgatc aagccgggga ccaaggagac agacaacgtc    660

tgtggcacac tcccgtcctt ctccagctcc acctcacctt cccctggcac agccatcttt    720

ccacgccctg agcacatgga aacccatgaa gtcccttcct ccacttatgt tcccaaaggc    780

atgaactcaa cagaatccaa ctcttctgcc tctgttagac caaaggtact gagtagcatc    840

caggaaggga cagtccctga caacacaagc tcagcaaggg ggaaggaaga cgtgaacaag    900

accctcccaa accttcaggt agtcaaccac cagcaaggcc cccaccacag acacatcctg    960

aagctgctgc cgtccatgga ggccactggg ggcgagaagt ccagcacgcc catcaagggc   1020

cccaagaggg gacatcctag acagaaccta cacaagcatt ttgacatcaa tgagcatttg   1080

ccctggatga ttgtgctttt cctgctgctg gtgcttgtgg tgattgtggt gtgcagtatc   1140

tag                                                                 1143


<210>  157
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dominant negative DR6 with Myc tag

<400>  157

Met Gly Thr Ser Pro Ser Ser Ser Thr Ala Leu Ala Ser Cys Ser Arg 
1               5                   10                  15      


Ile Ala Arg Arg Ala Thr Ala Thr Met Ile Ala Gly Ser Leu Leu Leu 
            20                  25                  30          


Leu Gly Phe Leu Ser Thr Thr Thr Ala Glu Gln Lys Leu Ile Ser Glu 
        35                  40                  45              


Glu Asp Leu Gln Pro Glu Gln Lys Ala Ser Asn Leu Ile Gly Thr Tyr 
    50                  55                  60                  


Arg His Val Asp Arg Ala Thr Gly Gln Val Leu Thr Cys Asp Lys Cys 
65                  70                  75                  80  


Pro Ala Gly Thr Tyr Val Ser Glu His Cys Thr Asn Thr Ser Leu Arg 
                85                  90                  95      


Val Cys Ser Ser Cys Pro Val Gly Thr Phe Thr Arg His Glu Asn Gly 
            100                 105                 110         


Ile Glu Lys Cys His Asp Cys Ser Gln Pro Cys Pro Trp Pro Met Ile 
        115                 120                 125             


Glu Lys Leu Pro Cys Ala Ala Leu Thr Asp Arg Glu Cys Thr Cys Pro 
    130                 135                 140                 


Pro Gly Met Phe Gln Ser Asn Ala Thr Cys Ala Pro His Thr Val Cys 
145                 150                 155                 160 


Pro Val Gly Trp Gly Val Arg Lys Lys Gly Thr Glu Thr Glu Asp Val 
                165                 170                 175     


Arg Cys Lys Gln Cys Ala Arg Gly Thr Phe Ser Asp Val Pro Ser Ser 
            180                 185                 190         


Val Met Lys Cys Lys Ala Tyr Thr Asp Cys Leu Ser Gln Asn Leu Val 
        195                 200                 205             


Val Ile Lys Pro Gly Thr Lys Glu Thr Asp Asn Val Cys Gly Thr Leu 
    210                 215                 220                 


Pro Ser Phe Ser Ser Ser Thr Ser Pro Ser Pro Gly Thr Ala Ile Phe 
225                 230                 235                 240 


Pro Arg Pro Glu His Met Glu Thr His Glu Val Pro Ser Ser Thr Tyr 
                245                 250                 255     


Val Pro Lys Gly Met Asn Ser Thr Glu Ser Asn Ser Ser Ala Ser Val 
            260                 265                 270         


Arg Pro Lys Val Leu Ser Ser Ile Gln Glu Gly Thr Val Pro Asp Asn 
        275                 280                 285             


Thr Ser Ser Ala Arg Gly Lys Glu Asp Val Asn Lys Thr Leu Pro Asn 
    290                 295                 300                 


Leu Gln Val Val Asn His Gln Gln Gly Pro His His Arg His Ile Leu 
305                 310                 315                 320 


Lys Leu Leu Pro Ser Met Glu Ala Thr Gly Gly Glu Lys Ser Ser Thr 
                325                 330                 335     


Pro Ile Lys Gly Pro Lys Arg Gly His Pro Arg Gln Asn Leu His Lys 
            340                 345                 350         


His Phe Asp Ile Asn Glu His Leu Pro Trp Met Ile Val Leu Phe Leu 
        355                 360                 365             


Leu Leu Val Leu Val Val Ile Val Val Cys Ser Ile 
    370                 375                 380 


<210>  158
<211>  1731
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  soluble DR6: Fc

<400>  158
atggggacct ctccgagcag cagcaccgcc ctcgcctcct gcagccgcat cgcccgccga     60

gccacagcca cgatgatcgc gggctccctt ctcctgcttg gattccttag caccaccaca    120

gctcagccag aacagaaggc ctcgaatctc attggcacat accgccatgt tgaccgtgcc    180

accggccagg tgctaacctg tgacaagtgt ccagcaggaa cctatgtctc tgagcattgt    240

accaacacaa gcctgcgcgt ctgcagcagt tgccctgtgg ggacctttac caggcatgag    300

aatggcatag agaaatgcca tgactgtagt cagccatgcc catggccaat gattgagaaa    360

ttaccttgtg ctgccttgac tgaccgagaa tgcacttgcc cacctggcat gttccagtct    420

aacgctacct gtgcccccca tacggtgtgt cctgtgggtt ggggtgtgcg gaagaaaggg    480

acagagactg aggatgtgcg gtgtaagcag tgtgctcggg gtaccttctc agatgtgcct    540

tctagtgtga tgaaatgcaa agcatacaca gactgtctga gtcagaacct ggtggtgatc    600

aagccgggga ccaaggagac agacaacgtc tgtggcacac tcccgtcctt ctccagctcc    660

acctcacctt cccctggcac agccatcttt ccacgccctg agcacatgga aacccatgaa    720

gtcccttcct ccacttatgt tcccaaaggc atgaactcaa cagaatccaa ctcttctgcc    780

tctgttagac caaaggtact gagtagcatc caggaaggga cagtccctga caacacaagc    840

tcagcaaggg ggaaggaaga cgtgaacaag accctcccaa accttcaggt agtcaaccac    900

cagcaaggcc cccaccacag acacatcctg aagctgctgc cgtccatgga ggccactggg    960

ggcgagaagt ccagcacgcc catcaagggc cccaagaggg gacatcctag acagaaccta   1020

cacaagcatt ttgacatcaa tgagcatgtc gacaaaactc acacatgccc accgtgccca   1080

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc   1140

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac   1200

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag   1260

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac   1320

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc   1380

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc   1440

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa   1500

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac   1560

tacaagacca cgcctcccgt gttggactcc gacggctcct tcttcctcta cagcaagctc   1620

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag   1680

gctctgcaca accactacac gcagaagagc ctctccctgt ctcccgggtg a            1731


<210>  159
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  soluble DR6: Fc

<400>  159

Met Gly Thr Ser Pro Ser Ser Ser Thr Ala Leu Ala Ser Cys Ser Arg 
1               5                   10                  15      


Ile Ala Arg Arg Ala Thr Ala Thr Met Ile Ala Gly Ser Leu Leu Leu 
            20                  25                  30          


Leu Gly Phe Leu Ser Thr Thr Thr Ala Gln Pro Glu Gln Lys Ala Ser 
        35                  40                  45              


Asn Leu Ile Gly Thr Tyr Arg His Val Asp Arg Ala Thr Gly Gln Val 
    50                  55                  60                  


Leu Thr Cys Asp Lys Cys Pro Ala Gly Thr Tyr Val Ser Glu His Cys 
65                  70                  75                  80  


Thr Asn Thr Ser Leu Arg Val Cys Ser Ser Cys Pro Val Gly Thr Phe 
                85                  90                  95      


Thr Arg His Glu Asn Gly Ile Glu Lys Cys His Asp Cys Ser Gln Pro 
            100                 105                 110         


Cys Pro Trp Pro Met Ile Glu Lys Leu Pro Cys Ala Ala Leu Thr Asp 
        115                 120                 125             


Arg Glu Cys Thr Cys Pro Pro Gly Met Phe Gln Ser Asn Ala Thr Cys 
    130                 135                 140                 


Ala Pro His Thr Val Cys Pro Val Gly Trp Gly Val Arg Lys Lys Gly 
145                 150                 155                 160 


Thr Glu Thr Glu Asp Val Arg Cys Lys Gln Cys Ala Arg Gly Thr Phe 
                165                 170                 175     


Ser Asp Val Pro Ser Ser Val Met Lys Cys Lys Ala Tyr Thr Asp Cys 
            180                 185                 190         


Leu Ser Gln Asn Leu Val Val Ile Lys Pro Gly Thr Lys Glu Thr Asp 
        195                 200                 205             


Asn Val Cys Gly Thr Leu Pro Ser Phe Ser Ser Ser Thr Ser Pro Ser 
    210                 215                 220                 


Pro Gly Thr Ala Ile Phe Pro Arg Pro Glu His Met Glu Thr His Glu 
225                 230                 235                 240 


Val Pro Ser Ser Thr Tyr Val Pro Lys Gly Met Asn Ser Thr Glu Ser 
                245                 250                 255     


Asn Ser Ser Ala Ser Val Arg Pro Lys Val Leu Ser Ser Ile Gln Glu 
            260                 265                 270         


Gly Thr Val Pro Asp Asn Thr Ser Ser Ala Arg Gly Lys Glu Asp Val 
        275                 280                 285             


Asn Lys Thr Leu Pro Asn Leu Gln Val Val Asn His Gln Gln Gly Pro 
    290                 295                 300                 


His His Arg His Ile Leu Lys Leu Leu Pro Ser Met Glu Ala Thr Gly 
305                 310                 315                 320 


Gly Glu Lys Ser Ser Thr Pro Ile Lys Gly Pro Lys Arg Gly His Pro 
                325                 330                 335     


Arg Gln Asn Leu His Lys His Phe Asp Ile Asn Glu His Val Asp Lys 
            340                 345                 350         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        355                 360                 365             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    370                 375                 380                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
385                 390                 395                 400 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                405                 410                 415     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            420                 425                 430         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        435                 440                 445             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    450                 455                 460                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
465                 470                 475                 480 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
                485                 490                 495     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            500                 505                 510         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        515                 520                 525             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    530                 535                 540                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
545                 550                 555                 560 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                565                 570                 575     


<210>  160
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  DR6 siRNA

<400>  160
agaaacggcu ccuuuauua                                                  19


<210>  161
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  DR6 siRNA


<400>  161
ggaaggacau cuaucaguu                                                  19


<210>  162
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  DR6 siRNA


<400>  162
ggccgaugau ugagagauu                                                  19


<210>  163
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  DR6 siRNA


<400>  163
gcaguuggaa acagacaaa                                                  19


<210>  164
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  control siRNA


<400>  164
ggugacauga ucgacagcca u                                               21


<210>  165
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  165

Met Gly Ala Gly Ala Thr Gly Arg Ala Met Asp Gly Pro Arg Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Gly Val Ser Leu Gly Gly Ala Lys Glu Ala Cys 
            20                  25                  30          


Pro Thr Gly Leu Tyr Thr His Ser Gly Glu Cys Cys Lys Ala Cys Asn 
        35                  40                  45              


Leu Gly Glu Gly Val Ala Gln Pro Cys Gly Ala Asn Gln Thr Val Cys 
    50                  55                  60                  


Glu Pro Cys Leu Asp Ser Val Thr Phe Ser Asp Val Val Ser Ala Thr 
65                  70                  75                  80  


Glu Pro Cys Lys Pro Cys Thr Glu Cys Val Gly Leu Gln Ser Met Ser 
                85                  90                  95      


Ala Pro Cys Val Glu Ala Asp Asp Ala Val Cys Arg Cys Ala Tyr Gly 
            100                 105                 110         


Tyr Tyr Gln Asp Glu Thr Thr Gly Arg Cys Glu Ala Cys Arg Val Cys 
        115                 120                 125             


Glu Ala Gly Ser Gly Leu Val Phe Ser Cys Gln Asp Lys Gln Asn Thr 
    130                 135                 140                 


Val Cys Glu Glu Cys Pro Asp Gly Thr Tyr Ser Asp Glu Ala Asn His 
145                 150                 155                 160 


Val Asp Pro Cys Leu Pro Cys Thr Val Cys Glu Asp Thr Glu Arg Gln 
                165                 170                 175     


Leu Arg Glu Cys Thr Arg Trp Ala Asp Ala Glu Cys Glu Glu Ile Pro 
            180                 185                 190         


Gly Arg Trp Ile Thr Arg Ser Thr Pro Pro Glu Gly Ser Asp Ser Thr 
        195                 200                 205             


Ala Pro Ser Thr Gln Glu Pro Glu Ala Pro Pro Glu Gln Asp Leu Ile 
    210                 215                 220                 


Ala Ser Thr Val Ala Gly Val Val Thr Thr Val Met Gly Ser Ser Gln 
225                 230                 235                 240 


Pro Val Val Thr Arg Gly Thr Thr Asp Asn Leu Ile Pro Val Tyr Cys 
                245                 250                 255     


Ser Ile Leu Ala Ala Val Val Val Gly Leu Val Ala Tyr Ile Ala Phe 
            260                 265                 270         


Lys Arg Trp Asn Ser Cys Lys Gln Asn Lys Gln Gly Ala Asn Ser Arg 
        275                 280                 285             


Pro Val Asn Gln Thr Pro Pro Pro Glu Gly Glu Lys Leu His Ser Asp 
    290                 295                 300                 


Ser Gly Ile Ser Val Asp Ser Gln Ser Leu His Asp Gln Gln Pro His 
305                 310                 315                 320 


Thr Gln Thr Ala Ser Gly Gln Ala Leu Lys Gly Asp Gly Gly Leu Tyr 
                325                 330                 335     


Ser Ser Leu Pro Pro Ala Lys Arg Glu Glu Val Glu Lys Leu Leu Asn 
            340                 345                 350         


Gly Ser Ala Gly Asp Thr Trp Arg His Leu Ala Gly Glu Leu Gly Tyr 
        355                 360                 365             


Gln Pro Glu His Ile Asp Ser Phe Thr His Glu Ala Cys Pro Val Arg 
    370                 375                 380                 


Ala Leu Leu Ala Ser Trp Ala Thr Gln Asp Ser Ala Thr Leu Asp Ala 
385                 390                 395                 400 


Leu Leu Ala Ala Leu Arg Arg Ile Gln Arg Ala Asp Leu Val Glu Ser 
                405                 410                 415     


Leu Cys Ser Glu Ser Thr Ala Thr Ser Pro Val 
            420                 425         


<210>  166
<211>  3421
<212>  DNA
<213>  Homo sapiens

<400>  166
agagcgagcc gagccgcggc cagctccggc gggcaggggg ggcgctggag cgcagcgcag     60

cgcagcccca tcagtccgca aagcggaccg agctggaagt cgagcgctgc cgcgggaggc    120

gggcgatggg ggcaggtgcc accggccgcg ccatggacgg gccgcgcctg ctgctgttgc    180

tgcttctggg ggtgtccctt ggaggtgcca aggaggcatg ccccacaggc ctgtacacac    240

acagcggtga gtgctgcaaa gcctgcaacc tgggcgaggg tgtggcccag ccttgtggag    300

ccaaccagac cgtgtgtgag ccctgcctgg acagcgtgac gttctccgac gtggtgagcg    360

cgaccgagcc gtgcaagccg tgcaccgagt gcgtggggct ccagagcatg tcggcgccgt    420

gcgtggaggc cgacgacgcc gtgtgccgct gcgcctacgg ctactaccag gatgagacga    480

ctgggcgctg cgaggcgtgc cgcgtgtgcg aggcgggctc gggcctcgtg ttctcctgcc    540

aggacaagca gaacaccgtg tgcgaggagt gccccgacgg cacgtattcc gacgaggcca    600

accacgtgga cccgtgcctg ccctgcaccg tgtgcgagga caccgagcgc cagctccgcg    660

agtgcacacg ctgggccgac gccgagtgcg aggagatccc tggccgttgg attacacggt    720

ccacaccccc agagggctcg gacagcacag cccccagcac ccaggagcct gaggcacctc    780

cagaacaaga cctcatagcc agcacggtgg caggtgtggt gaccacagtg atgggcagct    840

cccagcccgt ggtgacccga ggcaccaccg acaacctcat ccctgtctat tgctccatcc    900

tggctgctgt ggttgtgggc cttgtggcct acatagcctt caagaggtgg aacagctgca    960

agcagaacaa gcaaggagcc aacagccggc cagtgaacca gacgccccca ccagagggag   1020

aaaaactcca cagcgacagt ggcatctccg tggacagcca gagcctgcat gaccagcagc   1080

cccacacgca gacagcctcg ggccaggccc tcaagggtga cggaggcctc tacagcagcc   1140

tgcccccagc caagcgggag gaggtggaga agcttctcaa cggctctgcg ggggacacct   1200

ggcggcacct ggcgggcgag ctgggctacc agcccgagca catagactcc tttacccatg   1260

aggcctgccc cgttcgcgcc ctgcttgcaa gctgggccac ccaggacagc gccacactgg   1320

acgccctcct ggccgccctg cgccgcatcc agcgagccga cctcgtggag agtctgtgca   1380

gtgagtccac tgccacatcc ccggtgtgag cccaaccggg gagcccccgc cccgccccac   1440

attccgacaa ccgatgctcc agccaacccc tgtggagccc gcacccccac cctttggggg   1500

gggcccgcct ggcagaactg agctcctctg ggcaggacct cagagtccag gccccaaaac   1560

cacagccctg tcagtgcagc ccgtgtggcc ccttcacttc tgaccacact tcctgtccag   1620

agagagaagt gcccctgctg cctccccaac cctgcccctg ccccgtcacc atctcaggcc   1680

acctgccccc ttctcccaca ctgctaggtg ggccagcccc tcccaccaca gcaggtgtca   1740

tatatggggg gccaacacca gggatggtac tagggggaag tgacaaggcc ccagagactc   1800

agagggagga atcgaggaac cagagccatg gactctacac tgtgaacttg gggaacaagg   1860

gtggcatccc agtggcctca accctccctc agcccctctt gccccccacc ccagcctaag   1920

atgaagagga tcggaggctt gtcagagctg ggaggggttt tcgaagctca gcccaccccc   1980

ctcattttgg atataggtca gtgaggccca gggagaggcc atgattcgcc caaagccaga   2040

cagcaacggg gaggccaagt gcaggctggc accgccttct ctaaatgagg ggcctcaggt   2100

ttgcctgagg gcgaggggag ggtggcaggt gaccttctgg gaaatggctt gaagccaagt   2160

cagctttgcc ttccacgctg tctccagacc cccacccctt ccccactgcc tgcccacccg   2220

tggagatggg atgcttgcct agggcctggt ccatgatgga gtcaggtttg gggttcgtgg   2280

aaagggtgct gcttccctct gcctgtccct ctcaggcatg cctgtgtgac atcagtggca   2340

tggctccagt ctgctgccct ccatcccgac atggacccgg agctaacact ggcccctaga   2400

atcagcctag gggtcaggga ccaaggaccc ctcaccttgc aacacacaga cacacgcaca   2460

cacacacaca ggaggagaaa tctcactttt ctccatgagt tttttctctt gggctgagac   2520

tggatactgc ccggggcagc tgccagagaa gcatcggagg gaattgaggt ctgctcggcc   2580

gtcttcactc gcccccgggt ttggcgggcc aaggactgcc gaccgaggct ggagctggcg   2640

tctgtcttca agggcttaca cgtggaggaa tgctccccca tcctcccctt ccctgcaaac   2700

atggggttgg ctgggcccag aaggttgtga tgaagaaaag tgggccagtg tgggaatgcg   2760

gcaagaagga attgacttcg actgtgacct gtggggattt ctcccagctc tagacaaccc   2820

tgcaaaggac tgttttttcc tgagcttggc cagaaggggg ccatgaggcc tcagtggact   2880

ttccaccccc tccctggcct gttctgtttt gcctgaagtt ggagtgagtg tggctcccct   2940

ctatttagca tgacaagccc caggcaggct gtgcgctgac aaccaccgct ccccagccca   3000

gggttccccc agccctgtgg aagggactag gagcactgta gtaaatggca attctttgac   3060

ctcaacctgt gatgagggga ggaaactcac ctgctggccc ctcacctggg cacctgggga   3120

gtgggacaga gtctgggtgt atttattttc ctccccagca ggtggggagg gggtttgggg   3180

gcttgcaagt atgttttagc atgtgtttgg ttctggggcc cctttttact ccccttgagc   3240

tgagatggaa cccttttggc ccccgagctg ggggccatga gctccagacc cccagcaacc   3300

ctcctatcac ctcccctcct tgcctcctgt gtaatcattt cttgggccct cctgaaactt   3360

acacacaaaa cgttaagtga tgaacattaa atagcaaaga aagaaaaata aaaaaaaaaa   3420

a                                                                   3421



