                         SEQUENCE LISTING

<110>  Strapps, Walter
       Pickering, Victoria
 
<120>  RNA Interference Mediated Inhibition of Epithelial Sodium Channel
       (ENaC) Gene Expression Using Short Interfering Nucleic Acid 
       (siNA)

<130>  SIRMIS72WPCT

<160>  150   

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1
gccauccgcc uggugugcu                                                    19


<210>  2
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2
ccauccgccu ggugugcuc                                                    19


<210>  3
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
cacaaccgca ugaagacgg                                                    19


<210>  4
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4
aaccgcauga agacggccu                                                    19


<210>  5
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5
accgcaugaa gacggccuu                                                    19


<210>  6
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6
ccgcaugaag acggccuuc                                                    19


<210>  7
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
cgcaugaaga cggccuucu                                                    19


<210>  8
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8
gcaugaagac ggccuucug                                                    19


<210>  9
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
cugugcaacc agaacaaau                                                    19


<210>  10
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10
ugugcaacca gaacaaauc                                                    19


<210>  11
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11
cagagcagaa ugacuucau                                                    19


<210>  12
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12
cccugcuguc cacagugac                                                    19


<210>  13
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
uuauggauga ugguggcuu                                                    19


<210>  14
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14
cacuccugcu uccaggaga                                                    19


<210>  15
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
aguguggcug ugccuacau                                                    19


<210>  16
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16
guguggcugu gccuacauc                                                    19


<210>  17
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
uguggcugug ccuacaucu                                                    19


<210>  18
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18
guggcugugc cuacaucuu                                                    19


<210>  19
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
uggcugugcc uacaucuuc                                                    19


<210>  20
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20
ggcugugccu acaucuucu                                                    19


<210>  21
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
gcugugccua caucuucua                                                    19


<210>  22
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22
cuccugucca accugggca                                                    19


<210>  23
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23
uccuguccaa ccugggcag                                                    19


<210>  24
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24
uguccaaccu gggcagcca                                                    19


<210>  25
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25
guccaaccug ggcagccag                                                    19


<210>  26
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26
aaccugggca gccagugga                                                    19


<210>  27
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27
accugggcag ccaguggag                                                    19


<210>  28
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28
ugggcagcca guggagccu                                                    19


<210>  29
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29
gggcagccag uggagccug                                                    19


<210>  30
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30
ggcagccagu ggagccugu                                                    19


<210>  31
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31
agccagugga gccuguggu                                                    19


<210>  32
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32
gccaguggag ccugugguu                                                    19


<210>  33
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  33
gccauccgcc uggugugcut t                                                 21


<210>  34
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  34
agcacaccag gcggauggcu u                                                 21


<210>  35
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  35
ccauccgccu ggugugcuct t                                                 21


<210>  36
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(21)
<223>  2'-O-methyl

<400>  36
gagcacacca ggcggauggu u                                                 21


<210>  37
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'fluoro

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'fluoro

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy-2'fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'fluoro

<220>
<221>  misc_feature
<222>  (12)..(16)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'fluoro

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  37
cacaaccgca ugaagacggt t                                                 21


<210>  38
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<400>  38
ccgucuucau gcgguugugu u                                                 21


<210>  39
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(13)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  39
aaccgcauga agacggccut t                                                 21


<210>  40
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  40
aggccgucuu caugcgguuu u                                                 21


<210>  41
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(12)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (16)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  41
accgcaugaa gacggccuut t                                                 21


<210>  42
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  42
aaggccgucu ucaugcgguu u                                                 21


<210>  43
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as desccribed for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(11)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (15)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  43
ccgcaugaag acggccuuct t                                                 21


<210>  44
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(21)
<223>  2'-O-methyl

<400>  44
gaaggccguc uucaugcggu u                                                 21


<210>  45
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (14)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  45
cgcaugaaga cggccuucut t                                                 21


<210>  46
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<400>  46
agaaggccgu cuucaugcgu u                                                 21


<210>  47
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(9)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  47
gcaugaagac ggccuucugt t                                                 21


<210>  48
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  48
cagaaggccg ucuucaugcu u                                                 21


<210>  49
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(14)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  49
cugugcaacc agaacaaaut t                                                 21


<210>  50
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(21)
<223>  2'-O-methyl

<400>  50
auuuguucug guugcacagu u                                                 21


<210>  51
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(13)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  51
ugugcaacca gaacaaauct t                                                 21


<210>  52
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<400>  52
gauuuguucu gguugcacau u                                                 21


<210>  53
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(5)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (14)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  53
cagagcagaa ugacuucaut t                                                 21


<210>  54
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<400>  54
augaagucau ucugcucugu u                                                 21


<210>  55
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  55
cccugcuguc cacagugact t                                                 21


<210>  56
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(21)
<223>  2'-O-methyl

<400>  56
gucacugugg acagcagggu u                                                 21


<210>  57
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  57
uuauggauga ugguggcuut t                                                 21


<210>  58
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(21)
<223>  2'-O-methyl

<400>  58
aagccaccau cauccauaau u                                                 21


<210>  59
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (9)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  59
cacuccugcu uccaggagat t                                                 21


<210>  60
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<400>  60
ucuccuggaa gcaggagugu u                                                 21


<210>  61
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  61
aguguggcug ugccuacaut t                                                 21


<210>  62
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  62
auguaggcac agccacacuu u                                                 21


<210>  63
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  63
guguggcugu gccuacauct t                                                 21


<210>  64
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  64
gauguaggca cagccacacu u                                                 21


<210>  65
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  65
uguggcugug ccuacaucut t                                                 21


<210>  66
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<400>  66
agauguaggc acagccacau u                                                 21


<210>  67
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (16)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  67
guggcugugc cuacaucuut t                                                 21


<210>  68
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  68
aagauguagg cacagccacu u                                                 21


<210>  69
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (15)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  69
uggcugugcc uacaucuuct t                                                 21


<210>  70
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<400>  70
gaagauguag gcacagccau u                                                 21


<210>  71
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (14)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  71
ggcugugccu acaucuucut t                                                 21


<210>  72
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  72
agaagauguc ggcacagccu u                                                 21


<210>  73
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (13)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  73
gcugugccua caucuucuat t                                                 21


<210>  74
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  74
uagaagaugu aggcacagcu u                                                 21


<210>  75
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  75
cuccugucca accugggcat t                                                 21


<210>  76
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(21)
<223>  2'-O-methyl

<400>  76
ugcccagguu ggacaggagu u                                                 21


<210>  77
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  77
uccuguccaa ccugggcagt t                                                 21


<210>  78
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(21)
<223>  2'-O-methyl

<400>  78
cugcccaggu uggacaggau u                                                 21


<210>  79
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  79
uguccaaccu gggcagccat t                                                 21


<210>  80
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<400>  80
uggcugccca gguuggacau u                                                 21


<210>  81
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  81
guccaaccug ggcagccagt t                                                 21


<210>  82
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  82
cuggcugccc agguuggacu u                                                 21


<210>  83
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  83
aaccugggca gccaguggat t                                                 21


<210>  84
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  84
uccacuggcu gcccagguuu u                                                 21


<210>  85
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  85
accugggcag ccaguggagt t                                                 21


<210>  86
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  86
cuccacuggc ugcccagguu u                                                 21


<210>  87
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(16)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  87
ugggcagcca guggagccut t                                                 21


<210>  88
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2'-O-methyl

<400>  88
aggcuccacu ggcugcccau u                                                 21


<210>  89
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(15)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (16)..(18)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  89
gggcagccag uggagccugt t                                                 21


<210>  90
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  90
caggcuccac uggcugcccu u                                                 21


<210>  91
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (11)..(14)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  91
ggcagccagu ggagccugut t                                                 21


<210>  92
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(8)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  92
acaggcucca cuggcugccu u                                                 21


<210>  93
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (8)..(11)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  93
agccagugga gccuguggut t                                                 21


<210>  94
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (9)..(12)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  94
accacaggcu ccacuggcuu u                                                 21


<210>  95
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted abasic cap

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(10)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted abasic cap

<400>  95
gccaguggag ccugugguut t                                                 21


<210>  96
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (10)..(13)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy-2'-fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2'-O-methyl

<400>  96
aaccacaggc uccacuggcu u                                                 21


<210>  97
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  97
cgactggagc acgaggacac tga                                               23


<210>  98
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  98
ggacactgac atggactgaa ggagta                                            26


<210>  99
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  99
ggaagacatc cagaggttgg                                                   20


<210>  100
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  100
ggttgcagga gacctggtt                                                    19


<210>  101
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  101
gccgcggata gaagatgtag                                                   20


<210>  102
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  102
tcctggaagc aggagtgaat                                                   20


<210>  103
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  103
ttctgtcgcg atagcatctg                                                   20


<210>  104
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  104
ccaggtggtc tgaggagaag                                                   20


<210>  105
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  105
ttctgtcgcg atagcatctg                                                   20


<210>  106
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  106
gcagagagct ggtagctggt                                                   20


<210>  107
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  107
gauuuguucu gguugcaca                                                    19


<210>  108
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  optional abasic, inverted abasic, inverted nucleotide or other 
       terminal cap

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional abasic, inverted abasic, inverted nucleotide or other 
       terminal cap

<400>  108
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210>  109
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  optional phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional 3'-3 attached terminal glyceryl moiety or optional 
       abasic, inverted abasic, inverted nucleotide or other terminal 
       cap

<400>  109
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210>  110
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide wherein any pyrimidine is 2'-deoxy-2'-fluoro or 
       2'-O-trifluoromethyl and any purine is 2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  optional phosphorothioate linkage

<400>  110
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210>  111
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide wherein any pyrimidine is 2'-deoxy-2'-fluoro or 
       2'-O-trifluoromethyl and any purine is 2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  optional phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional 3'-3 attached terminal glyceryl moiety or optional 
       abasic, inverted abasic, inverted nucleotide or other terminal 
       cap

<400>  111
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210>  112
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  optional abasic, inverted abasic, inverted nucleotide or other 
       terminal cap

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide wherein any pyrimidine is 2'-deoxy-2'-fluoro or 
       2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional abasic, inverted abasic, inverted nucleotide or other 
       terminal cap

<400>  112
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210>  113
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide wherein any pyrimidine is 2'-deoxy-2'-fluoro or 
       2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  optional phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional 3'-3 attached terminal glyceryl moiety or optional 
       abasic, inverted abasic, inverted nucleotide or other terminal 
       cap

<400>  113
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210>  114
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  optional abasic, inverted abasic, inverted nucleotide or other 
       terminal cap

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide wherein any pyrimidine is 2'-deoxy-2'-fluoro or 
       2'-O-trifluoromethyl and any purine is 2'-deoxy

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional abasic, inverted abasic, inverted nucleotide or other 
       terminal cap

<400>  114
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210>  115
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide wherein any pyrimidine is 2'-deoxy-2'-fluoro or 
       2'-O-trifluoromethyl and any purine is 2'-deoxy

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  optional phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional 3'-3 attached terminal glyceryl moiety or optional 
       abasic, inverted abasic, inverted nucleotide or other terminal 
       cap

<400>  115
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210>  116
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  optional abasic, inverted abasic, inverted nucleotide or other 
       terminal cap

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional abasic, inverted abasic, inverted nucleotide or other 
       terminal cap

<400>  116
ugugcaacca gaacaaaucn n                                                 21


<210>  117
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  optional phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional 3'-3 attached terminal glyceryl moiety or optional 
       abasic, inverted abasic, inverted nucleotide or other terminal 
       cap

<400>  117
gauuuguucu gguugcacan n                                                 21


<210>  118
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (10)..(13)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  oprtional phosphorothioate linkage

<400>  118
ugugcaacca gaacaaaucn n                                                 21


<210>  119
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (7)..(10)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  optional phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional 3'-3 attached terminal glyceryl moiety or optional 
       abasic, inverted abasic, inverted nucleotide or other terminal 
       cap

<400>  119
gauuuguucu gguugcacan n                                                 21


<210>  120
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  optional abasic, inverted abasic, inverted nucleotide or other 
       terminal cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional abasic, inverted abasic, inverted nucleotide or other 
       terminal cap

<400>  120
ugugcaacca gaacaaaucn n                                                 21


<210>  121
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (7)..(10)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  optional phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional 3'-3 attached terminal glyceryl moiety or optional 
       abasic, inverted abasic, inverted nucleotide or other terminal 
       cap

<400>  121
gauuuguucu gguugcacan n                                                 21


<210>  122
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  optional abasic, inverted abasic, inverted nucleotide or other 
       terminal cap

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (10)..(13)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (15)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional abasic, inverted abasic, inverted nucleotide or other 
       terminal cap

<400>  122
ugugcaacca gaacaaaucn n                                                 21


<210>  123
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (7)..(10)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2'-deoxy-2'-fluoro or 2'-O-trifluoromethyl

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2'-deoxy

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  optional phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  optional 3'-3 attached terminal glyceryl moiety or optional 
       abasic, inverted abasic, inverted nucleotide or other terminal 
       cap

<400>  123
gauuuguucu gguugcacan n                                                 21


<210>  124
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  124
aagccaccau cauccauaa                                                    19


<210>  125
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  125
gauguaggca cagccacac                                                    19


<210>  126
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  126
uagaagaugu aggcacagc                                                    19


<210>  127
<211>  3171
<212>  RNA
<213>  Homo sapiens NM_001038.4 as updated May 14, 2006

<400>  127
ccggccagcg ggcgggcucc ccagccaggc cgcugcaccu gucaggggaa caagcuggag       60

gagcaggacc cuagaccucu gcagcccaua ccaggucuca uggaggggaa caagcuggag      120

gagcaggacu cuagcccucc acaguccacu ccagggcuca ugaaggggaa caagcgugag      180

gagcaggggc ugggccccga accugcggcg ccccagcagc ccacggcgga ggaggaggcc      240

cugaucgagu uccaccgcuc cuaccgagag cucuucgagu ucuucugcaa caacaccacc      300

auccacggcg ccauccgccu ggugugcucc cagcacaacc gcaugaagac ggccuucugg      360

gcagugcugu ggcucugcac cuuuggcaug auguacuggc aauucggccu gcuuuucgga      420

gaguacuuca gcuaccccgu cagccucaac aucaaccuca acucggacaa gcucgucuuc      480

cccgcaguga ccaucugcac ccucaauccc uacagguacc cggaaauuaa agaggagcug      540

gaggagcugg accgcaucac agagcagacg cucuuugacc uguacaaaua cagcuccuuc      600

accacucucg uggccggcuc ccgcagccgu cgcgaccugc gggggacucu gccgcacccc      660

uugcagcgcc ugaggguccc gcccccgccu cacggggccc gucgagcccg uagcguggcc      720

uccagcuugc gggacaacaa cccccaggug gacuggaagg acuggaagau cggcuuccag      780

cugugcaacc agaacaaauc ggacugcuuc uaccagacau acucaucagg gguggaugcg      840

gugagggagu gguaccgcuu ccacuacauc aacauccugu cgaggcugcc agagacucug      900

ccaucccugg aggaggacac gcugggcaac uucaucuucg ccugccgcuu caaccagguc      960

uccugcaacc aggcgaauua cucucacuuc caccacccga uguauggaaa cugcuauacu     1020

uucaaugaca agaacaacuc caaccucugg augucuucca ugccuggaau caacaacggu     1080

cugucccuga ugcugcgcgc agagcagaau gacuucauuc cccugcuguc cacagugacu     1140

ggggcccggg uaauggugca cgggcaggau gaaccugccu uuauggauga ugguggcuuu     1200

aacuugcggc cuggcgugga gaccuccauc agcaugagga aggaaacccu ggacagacuu     1260

gggggcgauu auggcgacug caccaagaau ggcagugaug uuccuguuga gaaccuuuac     1320

ccuucaaagu acacacagca gguguguauu cacuccugcu uccaggagag caugaucaag     1380

gaguguggcu gugccuacau cuucuauccg cggccccaga acguggagua cugugacuac     1440

agaaagcaca guuccugggg guacugcuac uauaagcucc agguugacuu cuccucagac     1500

caccugggcu guuucaccaa gugccggaag ccaugcagcg ugaccagcua ccagcucucu     1560

gcugguuacu cacgauggcc cucggugaca ucccaggaau gggucuucca gaugcuaucg     1620

cgacagaaca auuacaccgu caacaacaag agaaauggag uggccaaagu caacaucuuc     1680

uucaaggagc ugaacuacaa aaccaauucu gagucucccu cugucacgau ggucacccuc     1740

cuguccaacc ugggcagcca guggagccug ugguucggcu ccucgguguu gucuguggug     1800

gagauggcug agcucgucuu ugaccugcug gucaucaugu uccucaugcu gcuccgaagg     1860

uuccgaagcc gauacugguc uccaggccga gggggcaggg gugcucagga gguagccucc     1920

acccuggcau ccuccccucc uucccacuuc ugcccccacc ccaugucucu guccuugucc     1980

cagccaggcc cugcucccuc uccagccuug acagccccuc ccccugccua ugccacccug     2040

ggcccccgcc caucuccagg gggcucugca ggggccaguu ccuccaccug uccucugggg     2100

gggcccugag agggaaggag agguuucuca caccaaggca gaugcuccuc uggugggagg     2160

gugcuggccc uggcaagauu gaaggaugug cagggcuucc ucucagagcc gcccaaacug     2220

ccguugaugu guggagggga agcaagaugg guaagggcuc aggaaguugc uccaagaaca     2280

guagcugaug aagcugccca gaagugccuu ggcuccagcc cuguaccccu ugguacugcc     2340

ucugaacacu cugguuuccc cacccaacug cggcuaaguc ucuuuuuccc uuggaucagc     2400

caagcgaaac uuggagcuuu gacaaggaac uuuccuaaga aaccgcugau aaccaggaca     2460

aaacacaacc aaggguacac gcaggcaugc acggguuucc ugcccagcga cggcuuaagc     2520

cagcccccga cuggccuggc cacacugcuc uccaguagca cagaugucug cuccuccucu     2580

ugaacuuggg ugggaaaccc cacccaaaag cccccuuugu uacuuaggca auuccccuuc     2640

ccugacuccc gagggcuagg gcuagagcag acccggguaa guaaaggcag acccagggcu     2700

ccucuagccu cauacccgug cccucacaga gccaugcccc ggcaccucug cccugugucu     2760

uucauaccuc uacaugucug cuugagauau uuccucagcc ugaaaguuuc cccaaccauc     2820

ugccagagaa cuccuaugca ucccuuagaa cccugcucag acaccauuac uuuugugaac     2880

gcuucugcca caucuugucu uccccaaaau ugaucacucc gccuucuccu gggcucccgu     2940

agcacacuau aacaucugcu ggaguguugc uguugcacca uacuuucuug uacauuugug     3000

ucucccuucc caacuagacu guaagugccu ugcggucagg gacugaaucu ugcccguuua     3060

uguaugcucc augucuagcc caucauccug cuuggagcaa guaggcagga gcucaauaaa     3120

uguuuguugc augaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a              3171

<210>  128
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  128
caaggtcatc catgacaact ttg                                               23


<210>  129
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  129
gggccatcca cagtcttct                                                    19


<210>  130
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  130
accacagtcc atgccatcac tgcca                                             25


<210>  131
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  131
acatcccagg aatgggtctt c                                                 21


<210>  132
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  132
actttggcca ctccatttct ct                                                22


<210>  133
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  133
tgctatcgcg acagaacaat tacaccgtc                                         29


<210>  134
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  134
acctaacccc caaatctatg tcaa                                              24


<210>  135
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  135
tggagaactc gccctctttc                                                   20


<210>  136
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  136
ctcatcgagg agtgcaccga cctg                                              24


<210>  137
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  137
ctggccgtgg ctctcttg                                                     18


<210>  138
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  138
ccttggcaaa actgcacctt                                                   20


<210>  139
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  139
cagccttcct gatttctgca gtctgtg                                           27


<210>  140
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  140
auauaucuau uucg                                                         14


<210>  141
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  141
cgaaauagau auau                                                         14


<210>  142
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  142
cgaaauagau auaucuauuu cg                                                22


<210>  143
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<400>  143
cgaaauagau auaucuauuu cgtt                                              24


<210>  144
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(30)
<223>  n is a, c, g, or u

<400>  144
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn                                        30


<210>  145
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  n is a, c, g, or u

<400>  145
nnnnnnnnnn nnnnnnnnnn nn                                                22


<210>  146
<211>  40
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(40)
<223>  n is a, c, g, or u

<400>  146
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn                             40


<210>  147
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  147
nnnnnnnnnn nnnnnnnnnn                                                   20


<210>  148
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  termincal cap which can be present or absent

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  termincal cap which can be present or absent

<400>  148
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210>  149
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence
<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  terminal cap which can be present or absent

<400>  149
nnnnnnnnnn nnnnnnnnnn n                                                 21


<210>  150
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  n stands for any nucleotide

<400>  150
nnnnnnnnnn nnnnnnnnnn n                                                 21




