                         SEQUENCE LISTING

<110>  KapaBiosystems
       Faurholm, Bjarne
       McEwan, Paul
       Bourn, William
       Rush, Gavin
 
<120>  Chimeric DNA Polymerases

<130>  2006735-0016

<150>  61/110,862
<151>  2008-11-03

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  2328
<212>  DNA
<213>  Pyrococcus furiosus

<400>  1
atgattttag atgtggatta cataactgaa gaaggaaaac ctgttattag gctattcaaa       60

aaagagaacg gaaaatttaa gatagagcat gatagaactt ttagaccata catttacgct      120

cttctcaggg atgattcaaa gattgaagaa gttaagaaaa taacggggga aaggcatgga      180

aagattgtga gaattgttga tgtagagaag gttgagaaaa agtttctcgg caagcctatt      240

accgtgtgga aactttattt ggaacatccc caagatgttc ccactattag agaaaaagtt      300

agagaacatc cagcagttgt ggacatcttc gaatacgata ttccatttgc aaagagatac      360

ctcatcgaca aaggcctaat accaatggag ggggaagaag agctaaagat tcttgccttc      420

gatatagaaa ccctctatca cgaaggagaa gagtttggaa aaggcccaat tataatgatt      480

agttatgcag atgaaaatga agcaaaggtg attacttgga aaaacataga tcttccatac      540

gttgaggttg tatcaagcga gagagagatg ataaagagat ttctcaggat tatcagggag      600

aaggatcctg acattatagt tacttataat ggagactcat tcgacttccc atatttagcg      660

aaaagggcag aaaaacttgg gattaaatta accattggaa gagatggaag cgagcccaag      720

atgcagagaa taggcgatat gacggctgta gaagtcaagg gaagaataca tttcgacttg      780

tatcatgtaa taacaaggac aataaatctc ccaacataca cactagaggc tgtatatgaa      840

gcaatttttg gaaagccaaa ggagaaggta tacgccgacg agatagcaaa agcctgggaa      900

agtggagaga accttgagag agttgccaaa tactcgatgg aagatgcaaa ggcaacttat      960

gaactcggga aagaattcct tccaatggaa attcagcttt caagattagt tggacaacct     1020

ttatgggatg tttcaaggtc aagcacaggg aaccttgtag agtggttctt acttaggaaa     1080

gcctacgaaa gaaacgaagt agctccaaac aagccaagtg aagaggagta tcaaagaagg     1140

ctcagggaga gctacacagg tggattcgtt aaagagccag aaaaggggtt gtgggaaaac     1200

atagtatacc tagattttag agccctatat ccctcgatta taattaccca caatgtttct     1260

cccgatactc taaatcttga gggatgcaag aactatgata tcgctcctca agtaggccac     1320

aagttctgca aggacatccc tggttttata ccaagtctct tgggacattt gttagaggaa     1380

agacaaaaga ttaagacaaa aatgaaggaa actcaagatc ctatagaaaa aatactcctt     1440

gactatagac aaaaagcgat aaaactctta gcaaattctt tctacggata ttatggctat     1500

gcaaaagcaa gatggtactg taaggagtgt gctgagagcg ttactgcctg gggaagaaag     1560

tacatcgagt tagtatggaa ggagctcgaa gaaaagtttg gatttaaagt cctctacatt     1620

gacactgatg gtctctatgc aactatccca ggaggagaaa gtgaggaaat aaagaaaaag     1680

gctctagaat ttgtaaaata cataaattca aagctccctg gactgctaga gcttgaatat     1740

gaagggtttt ataagagggg attcttcgtt acgaagaaga ggtatgcagt aatagatgaa     1800

gaaggaaaag tcattactcg tggtttagag atagttagga gagattggag tgaaattgca     1860

aaagaaactc aagctagagt tttggagaca atactaaaac acggagatgt tgaagaagct     1920

gtgagaatag taaaagaagt aatacaaaag cttgccaatt atgaaattcc accagagaag     1980

ctcgcaatat atgagcagat aacaagacca ttacatgagt ataaggcgat aggtcctcac     2040

gtagctgttg caaagaaact agctgctaaa ggagttaaaa taaagccagg aatggtaatt     2100

ggatacatag tacttagagg cgatggtcca attagcaata gggcaattct agctgaggaa     2160

tacgatccca aaaagcacaa gtatgacgca gaatattaca ttgagaacca ggttcttcca     2220

gcggtactta ggatattgga gggatttgga tacagaaagg aagacctcag ataccaaaag     2280

acaagacaag tcggcctaac ttcctggctt aacattaaaa aatcctag                  2328


<210>  2
<211>  2325
<212>  DNA
<213>  Thermococcus sp.

<400>  2
atgatcctcg acactgacta cataaccgag gatggaaagc ctgtcataag aattttcaag       60

aaggaaaacg gcgagtttaa gattgagtac gaccggactt ttgaacccta cttctacgcc      120

ctcctgaagg acgattctgc cattgaggaa gtcaagaaga taaccgccga gaggcacggg      180

acggttgtaa cggttaagcg ggttgaaaag gttcagaaga agttcctcgg gagaccagtt      240

gaggtctgga aactctactt tactcatccg caggacgtcc cagcgataag ggacaagata      300

cgagagcatc cagcagttat tgacatctac gagtacgaca tacccttcgc caagcgctac      360

ctcatagaca agggattagt gccaatggaa ggcgacgagg agctgaaaat gctcgccttc      420

gacattgaaa ctctctacca tgagggcgag gagttcgccg aggggccaat ccttatgata      480

agctacgccg acgaggaagg ggccagggtg ataacttgga agaacgtgga tctcccctac      540

gttgacgtcg tctcgacgga gagggagatg ataaagcgct tcctccgtgt tgtgaaggag      600

aaagacccgg acgttctcat aacctacaac ggcgacaact tcgacttcgc ctatctgaaa      660

aagcgctgtg aaaagctcgg aataaacttc gccctcggaa gggatggaag cgagccgaag      720

attcagagga tgggcgacag gtttgccgtc gaagtgaagg gacggataca cttcgatctc      780

tatcctgtga taagacggac gataaacctg cccacataca cgcttgaggc cgtttatgaa      840

gccgtcttcg gtcagccgaa ggagaaggtt tacgctgagg aaataaccac agcctgggaa      900

accggcgaga accttgagag agtcgcccgc tactcgatgg aagatgcgaa ggtcacatac      960

gagcttggga aggagttcct tccgatggag gcccagcttt ctcgcttaat cggccagtcc     1020

ctctgggacg tctcccgctc cagcactggc aacctcgttg agtggttcct cctcaggaag     1080

gcctatgaga ggaatgagct ggccccgaac aagcccgatg aaaaggagct ggccagaaga     1140

cggcagagct atgaaggagg ctatgtaaaa gagcccgaga gagggttgtg ggagaacata     1200

gtgtacctag attttagatc cctgtacccc tcaatcatca tcacccacaa cgtctcgccg     1260

gatacgctca acagagaagg atgcaaggaa tatgacgttg ccccacaggt cggccaccgc     1320

ttctgcaagg acttcccagg atttatcccg agcctgcttg gagacctcct agaggagagg     1380

cagaagataa agaagaagat gaaggccacg attgacccga tcgagaggaa gctcctcgat     1440

tacaggcaga gggccatcaa gatcctggca aacagctact acggttacta cggctatgca     1500

agggcgcgct ggtactgcaa ggagtgtgca gagagcgtaa cggcctgggg aagggagtac     1560

ataacgatga ccatcaagga gatagaggaa aagtacggct ttaaggtaat ctacagcgac     1620

accgacggat tttttgccac aatacctgga gccgatgctg aaaccgtcaa aaagaaggct     1680

atggagttcc tcaagtatat caacgccaaa cttccgggcg cgcttgagct cgagtacgag     1740

ggcttctaca aacgcggctt cttcgtcacg aagaagaagt atgcggtgat agacgaggaa     1800

ggcaagataa caacgcgcgg acttgagatt gtgaggcgtg actggagcga gatagcgaaa     1860

gagacgcagg cgagggttct tgaagctttg ctaaaggacg gtgacgtcga gaaggccgtg     1920

aggatagtca aagaagttac cgaaaagctg agcaagtacg aggttccgcc ggagaagctg     1980

gtgatccacg agcagataac gagggattta aaggactaca aggcaaccgg tccccacgtt     2040

gccgttgcca agaggttggc cgcgagagga gtcaaaatac gccctggaac ggtgataagc     2100

tacatcgtgc tcaagggctc tgggaggata ggcgacaggg cgataccgtt cgacgagttc     2160

gacccgacga agcacaagta cgacgccgag tactacattg agaaccaggt tctcccagcc     2220

gttgagagaa ttctgagagc cttcggttac cgcaaggaag acctgcgcta ccagaagacg     2280

agacaggttg gtttgagtgc ttggctgaag ccgaagggaa cttga                     2325


<210>  3
<211>  2328
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pfu codon optimized nucleotide sequence

<400>  3
atgattctgg atgtggacta tatcaccgaa gagggcaaac cggttatacg tttatttaag       60

aaagagaatg gtaaattcaa gatcgagcat gaccgcacgt tccgtccata catttacgcg      120

ttgcttcggg atgatagcaa aattgaggaa gtcaaaaaga tcaccgggga acgtcatgga      180

aaaatagtaa gaattgtgga cgttgaaaaa gtcgaaaaga aatttctggg caaaccgatc      240

actgtatgga agctctatct ggaacatcct caggatgtgc ccacaattcg agaaaaagtt      300

cgtgagcacc cagccgtcgt ggatatattt gaatatgaca tcccttttgc aaaacgctac      360

ttaattgata aaggcctgat cccgatggag ggggaagaag aacttaaaat tctggctttt      420

gacatagaaa cgctctatca tgagggagaa gaatttggca aaggtcccat cattatgatt      480

tcttacgcgg atgagaacga agccaaggta atcacttgga aaaatattga cctgccgtac      540

gttgaagtgg tcagttcaga gcgggaaatg attaaacgtt ttttacgcat cattagagag      600

aaagatccag atataatcgt tacatataac ggcgactcct tcgattttcc ttacctggca      660

aaacgagctg aaaaattggg tattaaactt accatcgggc gtgacggatc ggaaccgaaa      720

atgcaacgca ttggcgatat gacggcggta gaggtgaaag gtcggataca ctttgatctg      780

tatcatgtca tcacccgtac tattaatctc cccacataca cgttagaagc cgtttatgag      840

gcaatattcg gcaagccgaa agaaaaagtg tacgctgacg aaatcgcgaa ggcatgggag      900

agcggcgaaa acctggagcg cgtagcaaaa tattctatgg aagatgctaa agcgacctac      960

gaattgggga aagaatttct tccaatggaa attcagctga gtcgtttagt cggacaacct     1020

ctgtgggacg tttcacgctc ctcgactggc aatctcgtgg agtggttcct gttgagaaaa     1080

gcctatgaac gaaacgaagt agcaccgaat aaaccaagcg aggaagaata tcagcgtcgc     1140

cttcgcgagt cttacacagg tgggtttgtt aaggaaccgg agaaaggtct ttgggaaaac     1200

atcgtgtatt tagatttccg tgcgctgtac cccagtatta taatcaccca caatgtctca     1260

cctgacacgc tcaacttgga aggttgcaaa aattatgata ttgctccgca agttggacat     1320

aagttttgta aagatattcc gggcttcatc ccgtccctgc ttggtcactt actggaagag     1380

cgccaaaaaa ttaagaccaa aatgaaagag actcaggatc ccattgaaaa gatcctgctc     1440

gattaccggc aaaaagccat taaattgctt gcaaactcgt tttatgggta ctatggctat     1500

gcgaaggctc gttggtactg caaagaatgt gccgagagcg tgacagcatg gggtcgcaaa     1560

tatatagaat tagtatggaa ggagctggaa gaaaaattcg gattcaaagt cctgtacatc     1620

gatacggatg gcctctatgc gaccattcct ggtggggagt ctgaagaaat caagaaaaaa     1680

gccttggaat tcgttaagta cattaatagt aaattaccgg gactgcttga actggagtat     1740

gaaggcttct acaaaagagg ttttttcgtt actaagaaac gatatgccgt aatagatgaa     1800

gaggggaaag tcatcacacg tggcctcgag attgttcgcc gggactggtc agagatagca     1860

aaggaaacgc aggcgcgcgt gctcgaaacc atcttgaaac atggtgatgt agaggaagcc     1920

gtccgcattg ttaaagaggt gatccagaag ttagcaaact atgaaattcc accggaaaaa     1980

ctggcgatat acgagcaaat cactcgtccc cttcacgaat ataaagctat tggacctcat     2040

gtagccgtcg cgaagaaact ggctgcaaaa ggcgttaaga taaaaccagg tatggtgatc     2100

gggtacattg tactccgcgg cgacggtccg atttccaata gagccatctt ggcggaggaa     2160

tatgatccta aaaagcataa atacgacgct gaatattaca ttgagaacca ggtcttgccg     2220

gcagttctgc ggatacttga aggatttggc tatcgtaaag aagatctgcg ctatcaaaag     2280

acgcgacagg tgggtctgac tagctggttg aatatcaaaa aatcgtaa                  2328


<210>  4
<211>  2337
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pfu codon optimized nucleotide sequence, extra 9 nt in 5' area

<400>  4
atggctagcg ccattctgga tgtggactat atcaccgaag agggcaaacc ggttatacgt       60

ttatttaaga aagagaatgg taaattcaag atcgagcatg accgcacgtt ccgtccatac      120

atttacgcgt tgcttcggga tgatagcaaa attgaggaag tcaaaaagat caccggggaa      180

cgtcatggaa aaatagtaag aattgtggac gttgaaaaag tcgaaaagaa atttctgggc      240

aaaccgatca ctgtatggaa gctctatctg gaacatcctc aggatgtgcc cacaattcga      300

gaaaaagttc gtgagcaccc agccgtcgtg gatatatttg aatatgacat cccttttgca      360

aaacgctact taattgataa aggcctgatc ccgatggagg gggaagaaga acttaaaatt      420

ctggcttttg acatagaaac gctctatcat gagggagaag aatttggcaa aggtcccatc      480

attatgattt cttacgcgga tgagaacgaa gccaaggtaa tcacttggaa aaatattgac      540

ctgccgtacg ttgaagtggt cagttcagag cgggaaatga ttaaacgttt tttacgcatc      600

attagagaga aagatccaga tataatcgtt acatataacg gcgactcctt cgattttcct      660

tacctggcaa aacgagctga aaaattgggt attaaactta ccatcgggcg tgacggatcg      720

gaaccgaaaa tgcaacgcat tggcgatatg acggcggtag aggtgaaagg tcggatacac      780

tttgatctgt atcatgtcat cacccgtact attaatctcc ccacatacac gttagaagcc      840

gtttatgagg caatattcgg caagccgaaa gaaaaagtgt acgctgacga aatcgcgaag      900

gcatgggaga gcggcgaaaa cctggagcgc gtagcaaaat attctatgga agatgctaaa      960

gcgacctacg aattggggaa agaatttctt ccaatggaaa ttcagctgag tcgtttagtc     1020

ggacaacctc tgtgggacgt ttcacgctcc tcgactggca atctcgtgga gtggttcctg     1080

ttgagaaaag cctatgaacg aaacgaagta gcaccgaata aaccaagcga ggaagaatat     1140

cagcgtcgcc ttcgcgagtc ttacacaggt gggtttgtta aggaaccgga gaaaggtctt     1200

tgggaaaaca tcgtgtattt agatttccgt gcgctgtacc ccagtattat aatcacccac     1260

aatgtctcac ctgacacgct caacttggaa ggttgcaaaa attatgatat tgctccgcaa     1320

gttggacata agttttgtaa agatattccg ggcttcatcc cgtccctgct tggtcactta     1380

ctggaagagc gccaaaaaat taagaccaaa atgaaagaga ctcaggatcc cattgaaaag     1440

atcctgctcg attaccggca aaaagccatt aaattgcttg caaactcgtt ttatgggtac     1500

tatggctatg cgaaggctcg ttggtactgc aaagaatgtg ccgagagcgt gacagcatgg     1560

ggtcgcaaat atatagaatt agtatggaag gagctggaag aaaaattcgg attcaaagtc     1620

ctgtacatcg atacggatgg cctctatgcg accattcctg gtggggagtc tgaagaaatc     1680

aagaaaaaag ccttggaatt cgttaagtac attaatagta aattaccggg actgcttgaa     1740

ctggagtatg aaggcttcta caaaagaggt tttttcgtta ctaagaaacg atatgccgta     1800

atagatgaag aggggaaagt catcacacgt ggcctcgaga ttgttcgccg ggactggtca     1860

gagatagcaa aggaaacgca ggcgcgcgtg ctcgaaacca tcttgaaaca tggtgatgta     1920

gaggaagccg tccgcattgt taaagaggtg atccagaagt tagcaaacta tgaaattcca     1980

ccggaaaaac tggcgatata cgagcaaatc actcgtcccc ttcacgaata taaagctatt     2040

ggacctcatg tagccgtcgc gaagaaactg gctgcaaaag gcgttaagat aaaaccaggt     2100

atggtgatcg ggtacattgt actccgcggc gacggtccga tttccaatag agccatcttg     2160

gcggaggaat atgatcctaa aaagcataaa tacgacgctg aatattacat tgagaaccag     2220

gtcttgccgg cagttctgcg gatacttgaa ggatttggct atcgtaaaga agatctgcgc     2280

tatcaaaaga cgcgacaggt gggtctgact agctggttga atatcaaaaa atcgtaa        2337


<210>  5
<211>  2325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KOD codon optimized nucleotide sequence

<400>  5
atgattctgg ataccgacta tatcacggaa gatggcaaac cggtgatacg tatttttaag       60

aaagagaatg gtgagttcaa aatcgagtac gaccgcactt ttgagccata tttctacgcg      120

ttactgaagg acgatagcgc cattgaagaa gttaaaaaaa tcaccgcaga gcggcatggg      180

acagtggtaa ccgtgaagag agttgaaaaa gtccagaaaa aatttttggg acgacctgta      240

gaagtgtgga aactttattt cactcacccc caagatgttc cggctatacg tgataaaatt      300

cgcgaacatc cagcggtcat tgatatttac gaatatgata taccttttgc caagcgttac      360

ctcatcgaca aaggcctggt gccgatggaa ggtgatgaag aattaaaaat gttggcattc      420

gacattgaaa cactttatca cgagggggaa gagtttgctg agggtcccat cctgatgatt      480

tcttatgcgg atgaagaggg tgcccgcgta ataacctgga agaacgttga tctcccgtac      540

gtggacgtcg ttagtacgga acgggaaatg atcaaacgtt tcctgcgcgt agtgaaagag      600

aaagatccag acgtcttaat tacctataat ggtgataact ttgattttgc atacctgaaa      660

aaaagatgcg aaaagttggg cataaatttc gctcttggtc gagacgggtc agagcctaaa      720

atccagcgta tgggagatcg ctttgcggtt gaagtgaaag gccggattca tttcgacctg      780

tatccggtaa ttcgtcgcac tatcaacctc cccacataca cgttagaagc cgtctatgag      840

gcagtttttg gtcaaccgaa ggaaaaagtt tacgctgagg aaattaccac tgcgtgggaa      900

acaggcgaga atctggaacg tgtagcccgc tattctatgg aggatgcaaa agttacctat      960

gaattgggta aggaatttct tccaatggag gcgcagctgt cgagattaat agggcagagc     1020

ctgtgggacg tgtctcgaag ttcaacggga aacctcgtcg aatggtttct gttgcggaaa     1080

gcatacgagc gtaatgaact tgcccctaac aaaccggatg aaaaggagct ggcacgccgt     1140

cgccaatcct atgaaggcgg ttacgttaaa gaaccagagc gggggttatg ggaaaatatc     1200

gtgtatctgg atttccgttc gctctacccg agcattatca ttacccacaa cgtatctccc     1260

gacactttga atcgcgaggg ctgtaaagaa tatgatgtcg cgccgcaggt tggtcataga     1320

ttttgcaagg acttcccggg atttatacca agtctgcttg gcgatttact ggaagagcga     1380

caaaaaatca aaaagaaaat gaaagctaca atcgatccga tagaacgtaa gctgctcgac     1440

taccgccagc gggccatcaa aattttggca aactcatatt atggttacta tgggtacgcg     1500

cgtgctcgct ggtattgtaa agagtgcgcc gaatccgtga cggcatgggg ccgtgaatac     1560

atcaccatga ctattaagga gatagaagag aaatatggtt tcaaagtaat ctactcggat     1620

acagacggat tctttgcgac gattcccggt gccgatgcag aaaccgtcaa gaaaaaagcg     1680

atggaattcc ttaagtatat aaatgctaaa ttacctggtg ccctggagct ggaatacgaa     1740

gggttttaca aacgcggatt ctttgttact aagaaaaaat atgcggtgat cgacgaggaa     1800

ggcaagatta cgaccagagg cctcgagatt gtacggcgtg attggagcga aatcgctaaa     1860

gaaacacagg cacgtgtctt ggaggcatta ctgaaagatg gggacgttga aaaggcggtg     1920

cgaattgtaa aagaagtcac cgaaaaactt tctaagtacg aagttccgcc agagaaactg     1980

gtgatacacg aacaaatcac tcgtgatctg aaagactata aggctacagg cccgcatgta     2040

gcagtcgcca aacgcctcgc ggctcggggt gttaaaattc gtcccggaac ggtgatcagt     2100

tacattgtat tgaagggctc aggtcgcata ggggatagag caatcccttt cgacgagttt     2160

gatccaacca aacacaaata tgatgccgaa tactatattg aaaaccaggt cttgccggcg     2220

gttgagcgta tactgcgcgc tttcggctat cgaaaggaag atcttcgtta ccaaaaaact     2280

agacaggtgg gtctgtccgc atggctcaaa cctaagggaa cgtaa                     2325


<210>  6
<211>  2334
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KOD codon optimized nucleotide sequence, extra 9 nt in 5' area.

<400>  6
atggctagcg ccattctgga taccgactat atcacggaag atggcaaacc ggtgatacgt       60

atttttaaga aagagaatgg tgagttcaaa atcgagtacg accgcacttt tgagccatat      120

ttctacgcgt tactgaagga cgatagcgcc attgaagaag ttaaaaaaat caccgcagag      180

cggcatggga cagtggtaac cgtgaagaga gttgaaaaag tccagaaaaa atttttggga      240

cgacctgtag aagtgtggaa actttatttc actcaccccc aagatgttcc ggctatacgt      300

gataaaattc gcgaacatcc agcggtcatt gatatttacg aatatgatat accttttgcc      360

aagcgttacc tcatcgacaa aggcctggtg ccgatggaag gtgatgaaga attaaaaatg      420

ttggcattcg acattgaaac actttatcac gagggggaag agtttgctga gggtcccatc      480

ctgatgattt cttatgcgga tgaagagggt gcccgcgtaa taacctggaa gaacgttgat      540

ctcccgtacg tggacgtcgt tagtacggaa cgggaaatga tcaaacgttt cctgcgcgta      600

gtgaaagaga aagatccaga cgtcttaatt acctataatg gtgataactt tgattttgca      660

tacctgaaaa aaagatgcga aaagttgggc ataaatttcg ctcttggtcg agacgggtca      720

gagcctaaaa tccagcgtat gggagatcgc tttgcggttg aagtgaaagg ccggattcat      780

ttcgacctgt atccggtaat tcgtcgcact atcaacctcc ccacatacac gttagaagcc      840

gtctatgagg cagtttttgg tcaaccgaag gaaaaagttt acgctgagga aattaccact      900

gcgtgggaaa caggcgagaa tctggaacgt gtagcccgct attctatgga ggatgcaaaa      960

gttacctatg aattgggtaa ggaatttctt ccaatggagg cgcagctgtc gagattaata     1020

gggcagagcc tgtgggacgt gtctcgaagt tcaacgggaa acctcgtcga atggtttctg     1080

ttgcggaaag catacgagcg taatgaactt gcccctaaca aaccggatga aaaggagctg     1140

gcacgccgtc gccaatccta tgaaggcggt tacgttaaag aaccagagcg ggggttatgg     1200

gaaaatatcg tgtatctgga tttccgttcg ctctacccga gcattatcat tacccacaac     1260

gtatctcccg acactttgaa tcgcgagggc tgtaaagaat atgatgtcgc gccgcaggtt     1320

ggtcatagat tttgcaagga cttcccggga tttataccaa gtctgcttgg cgatttactg     1380

gaagagcgac aaaaaatcaa aaagaaaatg aaagctacaa tcgatccgat agaacgtaag     1440

ctgctcgact accgccagcg ggccatcaaa attttggcaa actcatatta tggttactat     1500

gggtacgcgc gtgctcgctg gtattgtaaa gagtgcgccg aatccgtgac ggcatggggc     1560

cgtgaataca tcaccatgac tattaaggag atagaagaga aatatggttt caaagtaatc     1620

tactcggata cagacggatt ctttgcgacg attcccggtg ccgatgcaga aaccgtcaag     1680

aaaaaagcga tggaattcct taagtatata aatgctaaat tacctggtgc cctggagctg     1740

gaatacgaag ggttttacaa acgcggattc tttgttacta agaaaaaata tgcggtgatc     1800

gacgaggaag gcaagattac gaccagaggc ctcgagattg tacggcgtga ttggagcgaa     1860

atcgctaaag aaacacaggc acgtgtcttg gaggcattac tgaaagatgg ggacgttgaa     1920

aaggcggtgc gaattgtaaa agaagtcacc gaaaaacttt ctaagtacga agttccgcca     1980

gagaaactgg tgatacacga acaaatcact cgtgatctga aagactataa ggctacaggc     2040

ccgcatgtag cagtcgccaa acgcctcgcg gctcggggtg ttaaaattcg tcccggaacg     2100

gtgatcagtt acattgtatt gaagggctca ggtcgcatag gggatagagc aatccctttc     2160

gacgagtttg atccaaccaa acacaaatat gatgccgaat actatattga aaaccaggtc     2220

ttgccggcgg ttgagcgtat actgcgcgct ttcggctatc gaaaggaaga tcttcgttac     2280

caaaaaacta gacaggtggg tctgtccgca tggctcaaac ctaagggaac gtaa           2334


<210>  7
<211>  5017
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pKB13 - Pfu codon optimized nucleotide sequence in pUC19 vector

<400>  7
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt cggtctcagc gccattctgg      420

ataccgacta tatcacggaa gatggcaaac cggtgatacg tatttttaag aaagagaatg      480

gtgagttcaa aatcgagtac gaccgcactt ttgagccata tttctacgcg ttactgaagg      540

acgatagcgc cattgaagaa gttaaaaaaa tcaccgcaga gcggcatggg acagtggtaa      600

ccgtgaagag agttgaaaaa gtccagaaaa aatttttggg acgacctgta gaagtgtgga      660

aactttattt cactcacccc caagatgttc cggctatacg tgataaaatt cgcgaacatc      720

cagcggtcat tgatatttac gaatatgata taccttttgc caagcgttac ctcatcgaca      780

aaggcctggt gccgatggaa ggtgatgaag aattaaaaat gttggcattc gacattgaaa      840

cactttatca cgagggggaa gagtttgctg agggtcccat cctgatgatt tcttatgcgg      900

atgaagaggg tgcccgcgta ataacctgga agaacgttga tctcccgtac gtggacgtcg      960

ttagtacgga acgggaaatg atcaaacgtt tcctgcgcgt agtgaaagag aaagatccag     1020

acgtcttaat tacctataat ggtgataact ttgattttgc atacctgaaa aaaagatgcg     1080

aaaagttggg cataaatttc gctcttggtc gagacgggtc agagcctaaa atccagcgta     1140

tgggagatcg ctttgcggtt gaagtgaaag gccggattca tttcgacctg tatccggtaa     1200

ttcgtcgcac tatcaacctc cccacataca cgttagaagc cgtctatgag gcagtttttg     1260

gtcaaccgaa ggaaaaagtt tacgctgagg aaattaccac tgcgtgggaa acaggcgaga     1320

atctggaacg tgtagcccgc tattctatgg aggatgcaaa agttacctat gaattgggta     1380

aggaatttct tccaatggag gcgcagctgt cgagattaat agggcagagc ctgtgggacg     1440

tgtctcgaag ttcaacggga aacctcgtcg aatggtttct gttgcggaaa gcatacgagc     1500

gtaatgaact tgcccctaac aaaccggatg aaaaggagct ggcacgccgt cgccaatcct     1560

atgaaggcgg ttacgttaaa gaaccagagc gggggttatg ggaaaatatc gtgtatctgg     1620

atttccgttc gctctacccg agcattatca ttacccacaa cgtatctccc gacactttga     1680

atcgcgaggg ctgtaaagaa tatgatgtcg cgccgcaggt tggtcataga ttttgcaagg     1740

acttcccggg atttatacca agtctgcttg gcgatttact ggaagagcga caaaaaatca     1800

aaaagaaaat gaaagctaca atcgatccga tagaacgtaa gctgctcgac taccgccagc     1860

gggccatcaa aattttggca aactcatatt atggttacta tgggtacgcg cgtgctcgct     1920

ggtattgtaa agagtgcgcc gaatccgtga cggcatgggg ccgtgaatac atcaccatga     1980

ctattaagga gatagaagag aaatatggtt tcaaagtaat ctactcggat acagacggat     2040

tctttgcgac gattcccggt gccgatgcag aaaccgtcaa gaaaaaagcg atggaattcc     2100

ttaagtatat aaatgctaaa ttacctggtg ccctggagct ggaatacgaa gggttttaca     2160

aacgcggatt ctttgttact aagaaaaaat atgcggtgat cgacgaggaa ggcaagatta     2220

cgaccagagg cctcgagatt gtacggcgtg attggagcga aatcgctaaa gaaacacagg     2280

cacgtgtctt ggaggcatta ctgaaagatg gggacgttga aaaggcggtg cgaattgtaa     2340

aagaagtcac cgaaaaactt tctaagtacg aagttccgcc agagaaactg gtgatacacg     2400

aacaaatcac tcgtgatctg aaagactata aggctacagg cccgcatgta gcagtcgcca     2460

aacgcctcgc ggctcggggt gttaaaattc gtcccggaac ggtgatcagt tacattgtat     2520

tgaagggctc aggtcgcata ggggatagag caatcccttt cgacgagttt gatccaacca     2580

aacacaaata tgatgccgaa tactatattg aaaaccaggt cttgccggcg gttgagcgta     2640

tactgcgcgc tttcggctat cgaaaggaag atcttcgtta ccaaaaaact agacaggtgg     2700

gtctgtccgc atggctcaaa cctaagggaa cgtaatgata tgagaccgga tcctctagag     2760

tcgacctgca ggcatgcaag cttggcgtaa tcatggtcat agctgtttcc tgtgtgaaat     2820

tgttatccgc tcacaattcc acacaacata cgagccggaa gcataaagtg taaagcctgg     2880

ggtgcctaat gagtgagcta actcacatta attgcgttgc gctcactgcc cgctttccag     2940

tcgggaaacc tgtcgtgcca gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt     3000

ttgcgtattg ggcgctcttc cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg     3060

ctgcggcgag cggtatcagc tcactcaaag gcggtaatac ggttatccac agaatcaggg     3120

gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag     3180

gccgcgttgc tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga     3240

cgctcaagtc agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct     3300

ggaagctccc tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc     3360

tttctccctt cgggaagcgt ggcgctttct catagctcac gctgtaggta tctcagttcg     3420

gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc     3480

tgcgccttat ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca     3540

ctggcagcag ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag     3600

ttcttgaagt ggtggcctaa ctacggctac actagaagaa cagtatttgg tatctgcgct     3660

ctgctgaagc cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc     3720

accgctggta gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga     3780

tctcaagaag atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca     3840

cgttaaggga ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat     3900

taaaaatgaa gttttaaatc aatctaaagt atatatgagt aaacttggtc tgacagttac     3960

caatgcttaa tcagtgaggc acctatctca gcgatctgtc tatttcgttc atccatagtt     4020

gcctgactcc ccgtcgtgta gataactacg atacgggagg gcttaccatc tggccccagt     4080

gctgcaatga taccgcgaga cccacgctca ccggctccag atttatcagc aataaaccag     4140

ccagccggaa gggccgagcg cagaagtggt cctgcaactt tatccgcctc catccagtct     4200

attaattgtt gccgggaagc tagagtaagt agttcgccag ttaatagttt gcgcaacgtt     4260

gttgccattg ctacaggcat cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc     4320

tccggttccc aacgatcaag gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt     4380

agctccttcg gtcctccgat cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg     4440

gttatggcag cactgcataa ttctcttact gtcatgccat ccgtaagatg cttttctgtg     4500

actggtgagt actcaaccaa gtcattctga gaatagtgta tgcggcgacc gagttgctct     4560

tgcccggcgt caatacggga taataccgcg ccacatagca gaactttaaa agtgctcatc     4620

attggaaaac gttcttcggg gcgaaaactc tcaaggatct taccgctgtt gagatccagt     4680

tcgatgtaac ccactcgtgc acccaactga tcttcagcat cttttacttt caccagcgtt     4740

tctgggtgag caaaaacagg aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg     4800

aaatgttgaa tactcatact cttccttttt caatattatt gaagcattta tcagggttat     4860

tgtctcatga gcggatacat atttgaatgt atttagaaaa ataaacaaat aggggttccg     4920

cgcacatttc cccgaaaagt gccacctgac gtctaagaaa ccattattat catgacatta     4980

acctataaaa ataggcgtat cacgaggccc tttcgtc                              5017


<210>  8
<211>  5017
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pKB8 - KOD codon optimized nucleotide sequence in pUC19 vector

<400>  8
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt cggtctcagc gccattctgg      420

ataccgacta tatcacggaa gatggcaaac cggtgatacg tatttttaag aaagagaatg      480

gtgagttcaa aatcgagtac gaccgcactt ttgagccata tttctacgcg ttactgaagg      540

acgatagcgc cattgaagaa gttaaaaaaa tcaccgcaga gcggcatggg acagtggtaa      600

ccgtgaagag agttgaaaaa gtccagaaaa aatttttggg acgacctgta gaagtgtgga      660

aactttattt cactcacccc caagatgttc cggctatacg tgataaaatt cgcgaacatc      720

cagcggtcat tgatatttac gaatatgata taccttttgc caagcgttac ctcatcgaca      780

aaggcctggt gccgatggaa ggtgatgaag aattaaaaat gttggcattc gacattgaaa      840

cactttatca cgagggggaa gagtttgctg agggtcccat cctgatgatt tcttatgcgg      900

atgaagaggg tgcccgcgta ataacctgga agaacgttga tctcccgtac gtggacgtcg      960

ttagtacgga acgggaaatg atcaaacgtt tcctgcgcgt agtgaaagag aaagatccag     1020

acgtcttaat tacctataat ggtgataact ttgattttgc atacctgaaa aaaagatgcg     1080

aaaagttggg cataaatttc gctcttggtc gagacgggtc agagcctaaa atccagcgta     1140

tgggagatcg ctttgcggtt gaagtgaaag gccggattca tttcgacctg tatccggtaa     1200

ttcgtcgcac tatcaacctc cccacataca cgttagaagc cgtctatgag gcagtttttg     1260

gtcaaccgaa ggaaaaagtt tacgctgagg aaattaccac tgcgtgggaa acaggcgaga     1320

atctggaacg tgtagcccgc tattctatgg aggatgcaaa agttacctat gaattgggta     1380

aggaatttct tccaatggag gcgcagctgt cgagattaat agggcagagc ctgtgggacg     1440

tgtctcgaag ttcaacggga aacctcgtcg aatggtttct gttgcggaaa gcatacgagc     1500

gtaatgaact tgcccctaac aaaccggatg aaaaggagct ggcacgccgt cgccaatcct     1560

atgaaggcgg ttacgttaaa gaaccagagc gggggttatg ggaaaatatc gtgtatctgg     1620

atttccgttc gctctacccg agcattatca ttacccacaa cgtatctccc gacactttga     1680

atcgcgaggg ctgtaaagaa tatgatgtcg cgccgcaggt tggtcataga ttttgcaagg     1740

acttcccggg atttatacca agtctgcttg gcgatttact ggaagagcga caaaaaatca     1800

aaaagaaaat gaaagctaca atcgatccga tagaacgtaa gctgctcgac taccgccagc     1860

gggccatcaa aattttggca aactcatatt atggttacta tgggtacgcg cgtgctcgct     1920

ggtattgtaa agagtgcgcc gaatccgtga cggcatgggg ccgtgaatac atcaccatga     1980

ctattaagga gatagaagag aaatatggtt tcaaagtaat ctactcggat acagacggat     2040

tctttgcgac gattcccggt gccgatgcag aaaccgtcaa gaaaaaagcg atggaattcc     2100

ttaagtatat aaatgctaaa ttacctggtg ccctggagct ggaatacgaa gggttttaca     2160

aacgcggatt ctttgttact aagaaaaaat atgcggtgat cgacgaggaa ggcaagatta     2220

cgaccagagg cctcgagatt gtacggcgtg attggagcga aatcgctaaa gaaacacagg     2280

cacgtgtctt ggaggcatta ctgaaagatg gggacgttga aaaggcggtg cgaattgtaa     2340

aagaagtcac cgaaaaactt tctaagtacg aagttccgcc agagaaactg gtgatacacg     2400

aacaaatcac tcgtgatctg aaagactata aggctacagg cccgcatgta gcagtcgcca     2460

aacgcctcgc ggctcggggt gttaaaattc gtcccggaac ggtgatcagt tacattgtat     2520

tgaagggctc aggtcgcata ggggatagag caatcccttt cgacgagttt gatccaacca     2580

aacacaaata tgatgccgaa tactatattg aaaaccaggt cttgccggcg gttgagcgta     2640

tactgcgcgc tttcggctat cgaaaggaag atcttcgtta ccaaaaaact agacaggtgg     2700

gtctgtccgc atggctcaaa cctaagggaa cgtaatgata tgagaccgga tcctctagag     2760

tcgacctgca ggcatgcaag cttggcgtaa tcatggtcat agctgtttcc tgtgtgaaat     2820

tgttatccgc tcacaattcc acacaacata cgagccggaa gcataaagtg taaagcctgg     2880

ggtgcctaat gagtgagcta actcacatta attgcgttgc gctcactgcc cgctttccag     2940

tcgggaaacc tgtcgtgcca gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt     3000

ttgcgtattg ggcgctcttc cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg     3060

ctgcggcgag cggtatcagc tcactcaaag gcggtaatac ggttatccac agaatcaggg     3120

gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag     3180

gccgcgttgc tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga     3240

cgctcaagtc agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct     3300

ggaagctccc tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc     3360

tttctccctt cgggaagcgt ggcgctttct catagctcac gctgtaggta tctcagttcg     3420

gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc     3480

tgcgccttat ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca     3540

ctggcagcag ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag     3600

ttcttgaagt ggtggcctaa ctacggctac actagaagaa cagtatttgg tatctgcgct     3660

ctgctgaagc cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc     3720

accgctggta gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga     3780

tctcaagaag atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca     3840

cgttaaggga ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat     3900

taaaaatgaa gttttaaatc aatctaaagt atatatgagt aaacttggtc tgacagttac     3960

caatgcttaa tcagtgaggc acctatctca gcgatctgtc tatttcgttc atccatagtt     4020

gcctgactcc ccgtcgtgta gataactacg atacgggagg gcttaccatc tggccccagt     4080

gctgcaatga taccgcgaga cccacgctca ccggctccag atttatcagc aataaaccag     4140

ccagccggaa gggccgagcg cagaagtggt cctgcaactt tatccgcctc catccagtct     4200

attaattgtt gccgggaagc tagagtaagt agttcgccag ttaatagttt gcgcaacgtt     4260

gttgccattg ctacaggcat cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc     4320

tccggttccc aacgatcaag gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt     4380

agctccttcg gtcctccgat cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg     4440

gttatggcag cactgcataa ttctcttact gtcatgccat ccgtaagatg cttttctgtg     4500

actggtgagt actcaaccaa gtcattctga gaatagtgta tgcggcgacc gagttgctct     4560

tgcccggcgt caatacggga taataccgcg ccacatagca gaactttaaa agtgctcatc     4620

attggaaaac gttcttcggg gcgaaaactc tcaaggatct taccgctgtt gagatccagt     4680

tcgatgtaac ccactcgtgc acccaactga tcttcagcat cttttacttt caccagcgtt     4740

tctgggtgag caaaaacagg aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg     4800

aaatgttgaa tactcatact cttccttttt caatattatt gaagcattta tcagggttat     4860

tgtctcatga gcggatacat atttgaatgt atttagaaaa ataaacaaat aggggttccg     4920

cgcacatttc cccgaaaagt gccacctgac gtctaagaaa ccattattat catgacatta     4980

acctataaaa ataggcgtat cacgaggccc tttcgtc                              5017


<210>  9
<211>  775
<212>  PRT
<213>  Pyrococcus furiosus

<400>  9

Met Ile Leu Asp Val Asp Tyr Ile Thr Glu Glu Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Leu Phe Lys Lys Glu Asn Gly Lys Phe Lys Ile Glu His Asp Arg 
            20                  25                  30          


Thr Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Arg Asp Asp Ser Lys Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Gly Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Val Asp Val Glu Lys Val Glu Lys Lys Phe Leu Gly Lys Pro Ile 
65                  70                  75                  80  


Thr Val Trp Lys Leu Tyr Leu Glu His Pro Gln Asp Val Pro Thr Ile 
                85                  90                  95      


Arg Glu Lys Val Arg Glu His Pro Ala Val Val Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Glu Glu Glu Leu Lys Ile Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Asn Glu Ala Lys Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Ile Ile Arg Glu Lys Asp Pro Asp Ile Ile Val Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Phe Pro Tyr Leu Ala Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Thr Ile Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Ile Gly Asp Met Thr Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Thr Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Asp Glu Ile Ala Lys Ala Trp Glu Ser Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Ala Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ile Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Val Ala 
        355                 360                 365             


Pro Asn Lys Pro Ser Glu Glu Glu Tyr Gln Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Tyr Thr Gly Gly Phe Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn 
385                 390                 395                 400 


Ile Val Tyr Leu Asp Phe Arg Ala Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Leu Glu Gly Cys Lys Asn Tyr 
            420                 425                 430         


Asp Ile Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Ile Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Gly His Leu Leu Glu Glu Arg Gln Lys Ile 
    450                 455                 460                 


Lys Thr Lys Met Lys Glu Thr Gln Asp Pro Ile Glu Lys Ile Leu Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Lys Ala Ile Lys Leu Leu Ala Asn Ser Phe Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Lys Tyr Ile Glu Leu Val Trp Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Gly Glu Ser Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Lys Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Lys Val Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Arg Val Leu Glu Thr Ile Leu Lys His Gly Asp Val Glu Glu Ala 
625                 630                 635                 640 


Val Arg Ile Val Lys Glu Val Ile Gln Lys Leu Ala Asn Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Ala Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Lys Leu Ala 
        675                 680                 685             


Ala Lys Gly Val Lys Ile Lys Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Asn Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Tyr Asp Pro Lys Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Gly Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Thr Ser 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Ser 
    770                 775 


<210>  10
<211>  778
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pfu amino acid sequence, extra 3 aa in 5' area.

<400>  10

Met Ala Ser Ala Ile Leu Asp Val Asp Tyr Ile Thr Glu Glu Gly Lys 
1               5                   10                  15      


Pro Val Ile Arg Leu Phe Lys Lys Glu Asn Gly Lys Phe Lys Ile Glu 
            20                  25                  30          


His Asp Arg Thr Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Arg Asp Asp 
        35                  40                  45              


Ser Lys Ile Glu Glu Val Lys Lys Ile Thr Gly Glu Arg His Gly Lys 
    50                  55                  60                  


Ile Val Arg Ile Val Asp Val Glu Lys Val Glu Lys Lys Phe Leu Gly 
65                  70                  75                  80  


Lys Pro Ile Thr Val Trp Lys Leu Tyr Leu Glu His Pro Gln Asp Val 
                85                  90                  95      


Pro Thr Ile Arg Glu Lys Val Arg Glu His Pro Ala Val Val Asp Ile 
            100                 105                 110         


Phe Glu Tyr Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly 
        115                 120                 125             


Leu Ile Pro Met Glu Gly Glu Glu Glu Leu Lys Ile Leu Ala Phe Asp 
    130                 135                 140                 


Ile Glu Thr Leu Tyr His Glu Gly Glu Glu Phe Gly Lys Gly Pro Ile 
145                 150                 155                 160 


Ile Met Ile Ser Tyr Ala Asp Glu Asn Glu Ala Lys Val Ile Thr Trp 
                165                 170                 175     


Lys Asn Ile Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu 
            180                 185                 190         


Met Ile Lys Arg Phe Leu Arg Ile Ile Arg Glu Lys Asp Pro Asp Ile 
        195                 200                 205             


Ile Val Thr Tyr Asn Gly Asp Ser Phe Asp Phe Pro Tyr Leu Ala Lys 
    210                 215                 220                 


Arg Ala Glu Lys Leu Gly Ile Lys Leu Thr Ile Gly Arg Asp Gly Ser 
225                 230                 235                 240 


Glu Pro Lys Met Gln Arg Ile Gly Asp Met Thr Ala Val Glu Val Lys 
                245                 250                 255     


Gly Arg Ile His Phe Asp Leu Tyr His Val Ile Thr Arg Thr Ile Asn 
            260                 265                 270         


Leu Pro Thr Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys 
        275                 280                 285             


Pro Lys Glu Lys Val Tyr Ala Asp Glu Ile Ala Lys Ala Trp Glu Ser 
    290                 295                 300                 


Gly Glu Asn Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys 
305                 310                 315                 320 


Ala Thr Tyr Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ile Gln Leu 
                325                 330                 335     


Ser Arg Leu Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr 
            340                 345                 350         


Gly Asn Leu Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn 
        355                 360                 365             


Glu Val Ala Pro Asn Lys Pro Ser Glu Glu Glu Tyr Gln Arg Arg Leu 
    370                 375                 380                 


Arg Glu Ser Tyr Thr Gly Gly Phe Val Lys Glu Pro Glu Lys Gly Leu 
385                 390                 395                 400 


Trp Glu Asn Ile Val Tyr Leu Asp Phe Arg Ala Leu Tyr Pro Ser Ile 
                405                 410                 415     


Ile Ile Thr His Asn Val Ser Pro Asp Thr Leu Asn Leu Glu Gly Cys 
            420                 425                 430         


Lys Asn Tyr Asp Ile Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp 
        435                 440                 445             


Ile Pro Gly Phe Ile Pro Ser Leu Leu Gly His Leu Leu Glu Glu Arg 
    450                 455                 460                 


Gln Lys Ile Lys Thr Lys Met Lys Glu Thr Gln Asp Pro Ile Glu Lys 
465                 470                 475                 480 


Ile Leu Leu Asp Tyr Arg Gln Lys Ala Ile Lys Leu Leu Ala Asn Ser 
                485                 490                 495     


Phe Tyr Gly Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu 
            500                 505                 510         


Cys Ala Glu Ser Val Thr Ala Trp Gly Arg Lys Tyr Ile Glu Leu Val 
        515                 520                 525             


Trp Lys Glu Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp 
    530                 535                 540                 


Thr Asp Gly Leu Tyr Ala Thr Ile Pro Gly Gly Glu Ser Glu Glu Ile 
545                 550                 555                 560 


Lys Lys Lys Ala Leu Glu Phe Val Lys Tyr Ile Asn Ser Lys Leu Pro 
                565                 570                 575     


Gly Leu Leu Glu Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe 
            580                 585                 590         


Val Thr Lys Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Lys Val Ile 
        595                 600                 605             


Thr Arg Gly Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys 
    610                 615                 620                 


Glu Thr Gln Ala Arg Val Leu Glu Thr Ile Leu Lys His Gly Asp Val 
625                 630                 635                 640 


Glu Glu Ala Val Arg Ile Val Lys Glu Val Ile Gln Lys Leu Ala Asn 
                645                 650                 655     


Tyr Glu Ile Pro Pro Glu Lys Leu Ala Ile Tyr Glu Gln Ile Thr Arg 
            660                 665                 670         


Pro Leu His Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys 
        675                 680                 685             


Lys Leu Ala Ala Lys Gly Val Lys Ile Lys Pro Gly Met Val Ile Gly 
    690                 695                 700                 


Tyr Ile Val Leu Arg Gly Asp Gly Pro Ile Ser Asn Arg Ala Ile Leu 
705                 710                 715                 720 


Ala Glu Glu Tyr Asp Pro Lys Lys His Lys Tyr Asp Ala Glu Tyr Tyr 
                725                 730                 735     


Ile Glu Asn Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Gly Phe 
            740                 745                 750         


Gly Tyr Arg Lys Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly 
        755                 760                 765             


Leu Thr Ser Trp Leu Asn Ile Lys Lys Ser 
    770                 775             


<210>  11
<211>  774
<212>  PRT
<213>  Thermococcus sp.

<400>  11

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Val Val Thr 
    50                  55                  60                  


Val Lys Arg Val Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Pro Ala Val Ile Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Val Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Val 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Lys Leu Gly Ile Asn Phe Ala Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Thr Thr Ala Trp Glu Thr Gly Glu Asn 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Lys Glu Leu Ala Arg Arg Arg Gln Ser Tyr 
    370                 375                 380                 


Glu Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Arg Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Arg Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Arg Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Glu Tyr Ile Thr Met Thr Ile Lys Glu Ile 
        515                 520                 525             


Glu Glu Lys Tyr Gly Phe Lys Val Ile Tyr Ser Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Met Glu Phe Leu Lys Tyr Ile Asn Ala Lys Leu Pro Gly Ala Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asp Val Glu Lys Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Ser Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Gly Thr 
    770                 


<210>  12
<211>  777
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KOD amino acid sequence, extra 3 aa in 5' area.

<400>  12

Met Ala Ser Ala Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys 
1               5                   10                  15      


Pro Val Ile Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu 
            20                  25                  30          


Tyr Asp Arg Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp 
        35                  40                  45              


Ser Ala Ile Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr 
    50                  55                  60                  


Val Val Thr Val Lys Arg Val Glu Lys Val Gln Lys Lys Phe Leu Gly 
65                  70                  75                  80  


Arg Pro Val Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val 
                85                  90                  95      


Pro Ala Ile Arg Asp Lys Ile Arg Glu His Pro Ala Val Ile Asp Ile 
            100                 105                 110         


Tyr Glu Tyr Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly 
        115                 120                 125             


Leu Val Pro Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp 
    130                 135                 140                 


Ile Glu Thr Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile 
145                 150                 155                 160 


Leu Met Ile Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp 
                165                 170                 175     


Lys Asn Val Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Arg Glu 
            180                 185                 190         


Met Ile Lys Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val 
        195                 200                 205             


Leu Ile Thr Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys 
    210                 215                 220                 


Arg Cys Glu Lys Leu Gly Ile Asn Phe Ala Leu Gly Arg Asp Gly Ser 
225                 230                 235                 240 


Glu Pro Lys Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys 
                245                 250                 255     


Gly Arg Ile His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn 
            260                 265                 270         


Leu Pro Thr Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Gln 
        275                 280                 285             


Pro Lys Glu Lys Val Tyr Ala Glu Glu Ile Thr Thr Ala Trp Glu Thr 
    290                 295                 300                 


Gly Glu Asn Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys 
305                 310                 315                 320 


Val Thr Tyr Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ala Gln Leu 
                325                 330                 335     


Ser Arg Leu Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr 
            340                 345                 350         


Gly Asn Leu Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn 
        355                 360                 365             


Glu Leu Ala Pro Asn Lys Pro Asp Glu Lys Glu Leu Ala Arg Arg Arg 
    370                 375                 380                 


Gln Ser Tyr Glu Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp 
385                 390                 395                 400 


Glu Asn Ile Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile 
                405                 410                 415     


Ile Thr His Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys 
            420                 425                 430         


Glu Tyr Asp Val Ala Pro Gln Val Gly His Arg Phe Cys Lys Asp Phe 
        435                 440                 445             


Pro Gly Phe Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln 
    450                 455                 460                 


Lys Ile Lys Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Arg Lys 
465                 470                 475                 480 


Leu Leu Asp Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr 
                485                 490                 495     


Tyr Gly Tyr Tyr Gly Tyr Ala Arg Ala Arg Trp Tyr Cys Lys Glu Cys 
            500                 505                 510         


Ala Glu Ser Val Thr Ala Trp Gly Arg Glu Tyr Ile Thr Met Thr Ile 
        515                 520                 525             


Lys Glu Ile Glu Glu Lys Tyr Gly Phe Lys Val Ile Tyr Ser Asp Thr 
    530                 535                 540                 


Asp Gly Phe Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys 
545                 550                 555                 560 


Lys Lys Ala Met Glu Phe Leu Lys Tyr Ile Asn Ala Lys Leu Pro Gly 
                565                 570                 575     


Ala Leu Glu Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val 
            580                 585                 590         


Thr Lys Lys Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr 
        595                 600                 605             


Arg Gly Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu 
    610                 615                 620                 


Thr Gln Ala Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asp Val Glu 
625                 630                 635                 640 


Lys Ala Val Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr 
                645                 650                 655     


Glu Val Pro Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp 
            660                 665                 670         


Leu Lys Asp Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg 
        675                 680                 685             


Leu Ala Ala Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr 
    690                 695                 700                 


Ile Val Leu Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe 
705                 710                 715                 720 


Asp Glu Phe Asp Pro Thr Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile 
                725                 730                 735     


Glu Asn Gln Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly 
            740                 745                 750         


Tyr Arg Lys Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu 
        755                 760                 765             


Ser Ala Trp Leu Lys Pro Lys Gly Thr 
    770                 775         


<210>  13
<211>  2334
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pod codon optimized nucleotide sequence

<400>  13
atggctagcg ccattctgga tgtggactat atcaccgaag agggcaaacc ggttatacgt       60

ttatttaaga aagagaatgg taaattcaag atcgagcatg accgcacgtt ccgtccatac      120

atttacgcgt tgcttcggga tgatagcaaa attgaggaag tcaaaaagat caccggggaa      180

cgtcatggaa aaatagtaag aattgtggac gttgaaaaag tcgaaaagaa atttctgggc      240

aaaccgatca ctgtatggaa gctctatctg gaacatcctc aggatgtgcc cacaattcga      300

gaaaaagttc gtgagcaccc agccgtcgtg gatatatttg aatatgacat cccttttgca      360

aaacgctact taattgataa aggcctgatc ccgatggagg gggaagaaga acttaaaatt      420

ctggcttttg acatagaaac gctctatcat gagggagaag aatttggcaa aggtcccatc      480

attatgattt cttacgcgga tgagaacgaa gccaaggtaa tcacttggaa aaatattgac      540

ctgccgtacg ttgaagtggt cagttcagag cgggaaatga ttaaacgttt tttacgcatc      600

attagagaga aagatccaga tataatcgtt acatataacg gcgactcctt cgattttcct      660

tacctggcaa aacgagctga aaaattgggt attaaactta ccatcgggcg tgacggatcg      720

gaaccgaaaa tgcaacgcat tggcgatatg acggcggtag aggtgaaagg tcggatacac      780

tttgatctgt atcatgtcat cacccgtact attaatctcc ccacatacac gttagaagcc      840

gtttatgagg caatattcgg caagccgaaa gaaaaagtgt acgctgacga aatcgcgaag      900

gcatgggaga gcggcgaaaa cctggagcgc gtagcaaaat attctatgga agatgctaaa      960

gcgacctacg aattggggaa agaatttctt ccaatggaaa ttcagctgtc gagattaata     1020

gggcagagcc tgtgggacgt gtctcgaagt tcaacgggaa acctcgtcga atggtttctg     1080

ttgcggaaag catacgagcg taatgaactt gcccctaaca aaccggatga aaaggagctg     1140

gcacgccgtc gccaatccta tgaaggcggt tacgttaaag aaccagagcg ggggttatgg     1200

gaaaatatcg tgtatctgga tttccgttcg ctctacccga gcattatcat tacccacaac     1260

gtatctcccg acactttgaa tcgcgagggc tgtaaagaat atgatgtcgc gccgcaggtt     1320

ggtcatagat tttgcaagga cttcccggga tttataccaa gtctgcttgg cgatttactg     1380

gaagagcgac aaaaaatcaa aaagaaaatg aaagctacaa tcgatccgat agaacgtaag     1440

ctgctcgact accgccagcg ggccatcaaa attttggcaa actcatatta tggttactat     1500

gggtacgcgc gtgctcgctg gtattgtaaa gagtgcgccg aatccgtgac ggcatggggc     1560

cgtgaataca tcaccatgac tattaaggag atagaagaga aatatggttt caaagtaatc     1620

tactcggata cagacggatt ctttgcgacg attcccggtg ccgatgcaga aaccgtcaag     1680

aaaaaagcga tggaattcgt taagtacatt aatagtaaat taccgggact gcttgaactg     1740

gagtatgaag gcttctacaa aagaggtttt ttcgttacta agaaacgata tgccgtaata     1800

gatgaagagg ggaaagtcat cacacgtggc ctcgagattg ttcgccggga ctggtcagag     1860

atagcaaagg aaacgcaggc gcgcgtgctc gaaaccatct tgaaacatgg tgatgtagag     1920

gaagccgtcc gcattgttaa agaggtgatc cagaagttag caaactatga aattccaccg     1980

gaaaaactgg cgatatacga gcaaatcact cgtccccttc acgaatataa agctattgga     2040

cctcatgtag ccgtcgcgaa gaaactggct gcaaaaggcg ttaagataaa accaggtatg     2100

gtgatcgggt acattgtact ccgcggcgac ggtccgattt ccaatagagc catcttggcg     2160

gaggaatatg atcctaaaaa gcataaatac gacgctgaat attacattga gaaccaggtc     2220

ttgccggcag ttctgcggat acttgaagga tttggctatc gtaaagaaga tctgcgctat     2280

caaaagacgc gacaggtggg tctgactagc tggttgaata tcaaaaaatc gtaa           2334


<210>  14
<211>  2337
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kofu codon optimized nucleotide sequence

<400>  14
atggctagcg ccattctgga taccgactat atcacggaag atggcaaacc ggtgatacgt       60

atttttaaga aagagaatgg tgagttcaaa atcgagtacg accgcacttt tgagccatat      120

ttctacgcgt tactgaagga cgatagcgcc attgaagaag ttaaaaaaat caccgcagag      180

cggcatggga cagtggtaac cgtgaagaga gttgaaaaag tccagaaaaa atttttggga      240

cgacctgtag aagtgtggaa actttatttc actcaccccc aagatgttcc ggctatacgt      300

gataaaattc gcgaacatcc agcggtcatt gatatttacg aatatgatat accttttgcc      360

aagcgttacc tcatcgacaa aggcctggtg ccgatggaag gtgatgaaga attaaaaatg      420

ttggcattcg acattgaaac actttatcac gagggggaag agtttgctga gggtcccatc      480

ctgatgattt cttatgcgga tgaagagggt gcccgcgtaa taacctggaa gaacgttgat      540

ctcccgtacg tggacgtcgt tagtacggaa cgggaaatga tcaaacgttt cctgcgcgta      600

gtgaaagaga aagatccaga cgtcttaatt acctataatg gtgataactt tgattttgca      660

tacctgaaaa aaagatgcga aaagttgggc ataaatttcg ctcttggtcg agacgggtca      720

gagcctaaaa tccagcgtat gggagatcgc tttgcggttg aagtgaaagg ccggattcat      780

ttcgacctgt atccggtaat tcgtcgcact atcaacctcc ccacatacac gttagaagcc      840

gtctatgagg cagtttttgg tcaaccgaag gaaaaagttt acgctgagga aattaccact      900

gcgtgggaaa caggcgagaa tctggaacgt gtagcccgct attctatgga ggatgcaaaa      960

gttacctatg aattgggtaa ggaatttctt ccaatggagg cgcagctgag tcgtttagtc     1020

ggacaacctc tgtgggacgt ttcacgctcc tcgactggca atctcgtgga gtggttcctg     1080

ttgagaaaag cctatgaacg aaacgaagta gcaccgaata aaccaagcga ggaagaatat     1140

cagcgtcgcc ttcgcgagtc ttacacaggt gggtttgtta aggaaccgga gaaaggtctt     1200

tgggaaaaca tcgtgtattt agatttccgt gcgctgtacc ccagtattat aatcacccac     1260

aatgtctcac ctgacacgct caacttggaa ggttgcaaaa attatgatat tgctccgcaa     1320

gttggacata agttttgtaa agatattccg ggcttcatcc cgtccctgct tggtcactta     1380

ctggaagagc gccaaaaaat taagaccaaa atgaaagaga ctcaggatcc cattgaaaag     1440

atcctgctcg attaccggca aaaagccatt aaattgcttg caaactcgtt ttatgggtac     1500

tatggctatg cgaaggctcg ttggtactgc aaagaatgtg ccgagagcgt gacagcatgg     1560

ggtcgcaaat atatagaatt agtatggaag gagctggaag aaaaattcgg attcaaagtc     1620

ctgtacatcg atacggatgg cctctatgcg accattcctg gtggggagtc tgaagaaatc     1680

aagaaaaaag ccttggaatt ccttaagtat ataaatgcta aattacctgg tgccctggag     1740

ctggaatacg aagggtttta caaacgcgga ttctttgtta ctaagaaaaa atatgcggtg     1800

atcgacgagg aaggcaagat tacgaccaga ggcctcgaga ttgtacggcg tgattggagc     1860

gaaatcgcta aagaaacaca ggcacgtgtc ttggaggcat tactgaaaga tggggacgtt     1920

gaaaaggcgg tgcgaattgt aaaagaagtc accgaaaaac tttctaagta cgaagttccg     1980

ccagagaaac tggtgataca cgaacaaatc actcgtgatc tgaaagacta taaggctaca     2040

ggcccgcatg tagcagtcgc caaacgcctc gcggctcggg gtgttaaaat tcgtcccgga     2100

acggtgatca gttacattgt attgaagggc tcaggtcgca taggggatag agcaatccct     2160

ttcgacgagt ttgatccaac caaacacaaa tatgatgccg aatactatat tgaaaaccag     2220

gtcttgccgg cggttgagcg tatactgcgc gctttcggct atcgaaagga agatcttcgt     2280

taccaaaaaa ctagacaggt gggtctgtcc gcatggctca aacctaaggg aacgtaa        2337


<210>  15
<211>  777
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pod amino acid sequence

<400>  15

Met Ala Ser Ala Ile Leu Asp Val Asp Tyr Ile Thr Glu Glu Gly Lys 
1               5                   10                  15      


Pro Val Ile Arg Leu Phe Lys Lys Glu Asn Gly Lys Phe Lys Ile Glu 
            20                  25                  30          


His Asp Arg Thr Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Arg Asp Asp 
        35                  40                  45              


Ser Lys Ile Glu Glu Val Lys Lys Ile Thr Gly Glu Arg His Gly Lys 
    50                  55                  60                  


Ile Val Arg Ile Val Asp Val Glu Lys Val Glu Lys Lys Phe Leu Gly 
65                  70                  75                  80  


Lys Pro Ile Thr Val Trp Lys Leu Tyr Leu Glu His Pro Gln Asp Val 
                85                  90                  95      


Pro Thr Ile Arg Glu Lys Val Arg Glu His Pro Ala Val Val Asp Ile 
            100                 105                 110         


Phe Glu Tyr Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly 
        115                 120                 125             


Leu Ile Pro Met Glu Gly Glu Glu Glu Leu Lys Ile Leu Ala Phe Asp 
    130                 135                 140                 


Ile Glu Thr Leu Tyr His Glu Gly Glu Glu Phe Gly Lys Gly Pro Ile 
145                 150                 155                 160 


Ile Met Ile Ser Tyr Ala Asp Glu Asn Glu Ala Lys Val Ile Thr Trp 
                165                 170                 175     


Lys Asn Ile Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu 
            180                 185                 190         


Met Ile Lys Arg Phe Leu Arg Ile Ile Arg Glu Lys Asp Pro Asp Ile 
        195                 200                 205             


Ile Val Thr Tyr Asn Gly Asp Ser Phe Asp Phe Pro Tyr Leu Ala Lys 
    210                 215                 220                 


Arg Ala Glu Lys Leu Gly Ile Lys Leu Thr Ile Gly Arg Asp Gly Ser 
225                 230                 235                 240 


Glu Pro Lys Met Gln Arg Ile Gly Asp Met Thr Ala Val Glu Val Lys 
                245                 250                 255     


Gly Arg Ile His Phe Asp Leu Tyr His Val Ile Thr Arg Thr Ile Asn 
            260                 265                 270         


Leu Pro Thr Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys 
        275                 280                 285             


Pro Lys Glu Lys Val Tyr Ala Asp Glu Ile Ala Lys Ala Trp Glu Ser 
    290                 295                 300                 


Gly Glu Asn Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys 
305                 310                 315                 320 


Ala Thr Tyr Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ile Gln Leu 
                325                 330                 335     


Ser Arg Leu Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr 
            340                 345                 350         


Gly Asn Leu Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn 
        355                 360                 365             


Glu Leu Ala Pro Asn Lys Pro Asp Glu Lys Glu Leu Ala Arg Arg Arg 
    370                 375                 380                 


Gln Ser Tyr Glu Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp 
385                 390                 395                 400 


Glu Asn Ile Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile 
                405                 410                 415     


Ile Thr His Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys 
            420                 425                 430         


Glu Tyr Asp Val Ala Pro Gln Val Gly His Arg Phe Cys Lys Asp Phe 
        435                 440                 445             


Pro Gly Phe Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln 
    450                 455                 460                 


Lys Ile Lys Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Arg Lys 
465                 470                 475                 480 


Leu Leu Asp Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr 
                485                 490                 495     


Tyr Gly Tyr Tyr Gly Tyr Ala Arg Ala Arg Trp Tyr Cys Lys Glu Cys 
            500                 505                 510         


Ala Glu Ser Val Thr Ala Trp Gly Arg Glu Tyr Ile Thr Met Thr Ile 
        515                 520                 525             


Lys Glu Ile Glu Glu Lys Tyr Gly Phe Lys Val Ile Tyr Ser Asp Thr 
    530                 535                 540                 


Asp Gly Phe Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys 
545                 550                 555                 560 


Lys Lys Ala Met Glu Phe Val Lys Tyr Ile Asn Ser Lys Leu Pro Gly 
                565                 570                 575     


Leu Leu Glu Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val 
            580                 585                 590         


Thr Lys Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Lys Val Ile Thr 
        595                 600                 605             


Arg Gly Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu 
    610                 615                 620                 


Thr Gln Ala Arg Val Leu Glu Thr Ile Leu Lys His Gly Asp Val Glu 
625                 630                 635                 640 


Glu Ala Val Arg Ile Val Lys Glu Val Ile Gln Lys Leu Ala Asn Tyr 
                645                 650                 655     


Glu Ile Pro Pro Glu Lys Leu Ala Ile Tyr Glu Gln Ile Thr Arg Pro 
            660                 665                 670         


Leu His Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Lys 
        675                 680                 685             


Leu Ala Ala Lys Gly Val Lys Ile Lys Pro Gly Met Val Ile Gly Tyr 
    690                 695                 700                 


Ile Val Leu Arg Gly Asp Gly Pro Ile Ser Asn Arg Ala Ile Leu Ala 
705                 710                 715                 720 


Glu Glu Tyr Asp Pro Lys Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile 
                725                 730                 735     


Glu Asn Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Gly Phe Gly 
            740                 745                 750         


Tyr Arg Lys Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu 
        755                 760                 765             


Thr Ser Trp Leu Asn Ile Lys Lys Ser 
    770                 775         


<210>  16
<211>  778
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Kofu amino acid sequence

<400>  16

Met Ala Ser Ala Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys 
1               5                   10                  15      


Pro Val Ile Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu 
            20                  25                  30          


Tyr Asp Arg Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp 
        35                  40                  45              


Ser Ala Ile Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr 
    50                  55                  60                  


Val Val Thr Val Lys Arg Val Glu Lys Val Gln Lys Lys Phe Leu Gly 
65                  70                  75                  80  


Arg Pro Val Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val 
                85                  90                  95      


Pro Ala Ile Arg Asp Lys Ile Arg Glu His Pro Ala Val Ile Asp Ile 
            100                 105                 110         


Tyr Glu Tyr Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly 
        115                 120                 125             


Leu Val Pro Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp 
    130                 135                 140                 


Ile Glu Thr Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile 
145                 150                 155                 160 


Leu Met Ile Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp 
                165                 170                 175     


Lys Asn Val Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Arg Glu 
            180                 185                 190         


Met Ile Lys Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val 
        195                 200                 205             


Leu Ile Thr Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys 
    210                 215                 220                 


Arg Cys Glu Lys Leu Gly Ile Asn Phe Ala Leu Gly Arg Asp Gly Ser 
225                 230                 235                 240 


Glu Pro Lys Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys 
                245                 250                 255     


Gly Arg Ile His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn 
            260                 265                 270         


Leu Pro Thr Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Gln 
        275                 280                 285             


Pro Lys Glu Lys Val Tyr Ala Glu Glu Ile Thr Thr Ala Trp Glu Thr 
    290                 295                 300                 


Gly Glu Asn Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys 
305                 310                 315                 320 


Val Thr Tyr Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ala Gln Leu 
                325                 330                 335     


Ser Arg Leu Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr 
            340                 345                 350         


Gly Asn Leu Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn 
        355                 360                 365             


Glu Val Ala Pro Asn Lys Pro Ser Glu Glu Glu Tyr Gln Arg Arg Leu 
    370                 375                 380                 


Arg Glu Ser Tyr Thr Gly Gly Phe Val Lys Glu Pro Glu Lys Gly Leu 
385                 390                 395                 400 


Trp Glu Asn Ile Val Tyr Leu Asp Phe Arg Ala Leu Tyr Pro Ser Ile 
                405                 410                 415     


Ile Ile Thr His Asn Val Ser Pro Asp Thr Leu Asn Leu Glu Gly Cys 
            420                 425                 430         


Lys Asn Tyr Asp Ile Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp 
        435                 440                 445             


Ile Pro Gly Phe Ile Pro Ser Leu Leu Gly His Leu Leu Glu Glu Arg 
    450                 455                 460                 


Gln Lys Ile Lys Thr Lys Met Lys Glu Thr Gln Asp Pro Ile Glu Lys 
465                 470                 475                 480 


Ile Leu Leu Asp Tyr Arg Gln Lys Ala Ile Lys Leu Leu Ala Asn Ser 
                485                 490                 495     


Phe Tyr Gly Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu 
            500                 505                 510         


Cys Ala Glu Ser Val Thr Ala Trp Gly Arg Lys Tyr Ile Glu Leu Val 
        515                 520                 525             


Trp Lys Glu Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp 
    530                 535                 540                 


Thr Asp Gly Leu Tyr Ala Thr Ile Pro Gly Gly Glu Ser Glu Glu Ile 
545                 550                 555                 560 


Lys Lys Lys Ala Leu Glu Phe Leu Lys Tyr Ile Asn Ala Lys Leu Pro 
                565                 570                 575     


Gly Ala Leu Glu Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe 
            580                 585                 590         


Val Thr Lys Lys Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr 
        595                 600                 605             


Thr Arg Gly Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys 
    610                 615                 620                 


Glu Thr Gln Ala Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asp Val 
625                 630                 635                 640 


Glu Lys Ala Val Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys 
                645                 650                 655     


Tyr Glu Val Pro Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg 
            660                 665                 670         


Asp Leu Lys Asp Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys 
        675                 680                 685             


Arg Leu Ala Ala Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser 
    690                 695                 700                 


Tyr Ile Val Leu Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro 
705                 710                 715                 720 


Phe Asp Glu Phe Asp Pro Thr Lys His Lys Tyr Asp Ala Glu Tyr Tyr 
                725                 730                 735     


Ile Glu Asn Gln Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe 
            740                 745                 750         


Gly Tyr Arg Lys Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly 
        755                 760                 765             


Leu Ser Ala Trp Leu Lys Pro Lys Gly Thr 
    770                 775             


<210>  17
<211>  3778
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pLACIQZa

<400>  17
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcaggcgcc      240

attcgccatt caggctgcgc aactgttggg aagggcgatc ggtgcgggcc tcttcgctat      300

tacgccagct ggcgaaaggg ggatgtgctg caaggcgatt aagttgggta acgccagggt      360

tttcccagtc acgacgttgt aaaacgacgg ccagtgaatt cgagctcggt acccggggat      420

cctctagagc cgtaatcatg gtcatagctg tttcctgtgt gaaattgtta tccgctcaca      480

attccacaca acatacgagc cggaagcata aagtgtaaag cctggggtgc ctaatgagtg      540

agctaactca cattaattgc gttgcgctca ctgcccgctt tccagtcggg aaacctgtcg      600

tgccagctgc attaatgaat cggccaacgc gcggggagag gcggtttgcg tattgggcgc      660

cagggtggtt tttcttttca ccagtgagac gggcaacagc tgattgccct tcaccgcctg      720

gccctgagag agttgcagca agcggtccac gctggtttgc cccagcaggc gaaaatcctg      780

tttgatggtg gttgacggcg ggatataaca tgagctgtct tcggtatcgt cgtatcccac      840

taccgagata tccgcaccaa cgcgcagccc ggactcggta atggcgcgca ttgcgcccag      900

cgccatctga tcgttggcaa ccagcatcgc agtgggaacg atgccctcat tcagcatttg      960

catggtttgt tgaaaaccgg acatggcact ccagtcgcct tcccgttccg ctatcggctg     1020

aatttgattg cgagtgagat atttatgcca gccagccaga cgcagacgcg ccgagacaga     1080

acttaatggg cccgctaaca gcgcgatttg ctggtgaccc aatgcgacca gatgctccac     1140

gcccagtcgc gtaccgtctt catgggagaa aataatactg ttgatgggtg tctggtcaga     1200

gacatcaaga aataacgccg gaacattagt gcaggcagct tccacagcaa tggcatcctg     1260

gtcatccagc ggatagttaa tgatcagccc actgacgcgt tgcgcgagaa gattgtgcac     1320

cgccgcttta caggcttcga cgccgcttcg ttctaccatc gacaccacca cgctggcacc     1380

cagttgatcg gcgcgagatt taatcgccgc gacaatttgc gacggcgcgt gcagggccag     1440

actggaggtg gcaacgccaa tcagcaacga ctgtttgccc gccagttgtt gtgccacgcg     1500

gttgggaatg taattcagct ccgccatcgc cgcttccact ttttcccgcg ttttcgcaga     1560

aacgtggctg gcctggttca ccacgcggga aacggtctga taagagacac cggcatactc     1620

tgcgacatcg tataacgtta ctggtttcac attcaccacc ctgaattgac tctcttccgg     1680

gcgctatcat gccataccgc gaaaggtttt gcgccattcg atggtgtcaa cgtaaatgca     1740

tgccgcttcg ccttccggcc accagaatag cctgcgccat gggcttcctc gctcactgac     1800

tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa ggcggtaata     1860

cggttatcca cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa     1920

aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt tccataggct ccgcccccct     1980

gacgagcatc acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa     2040

agataccagg cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg     2100

cttaccggat acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcatagctca     2160

cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa     2220

ccccccgttc agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg     2280

gtaagacacg acttatcgcc actggcagca gccactggta acaggattag cagagcgagg     2340

tatgtaggcg gtgctacaga gttcttgaag tggtggccta actacggcta cactagaaga     2400

acagtatttg gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc     2460

tcttgatccg gcaaacaaac caccgctggt agcggtggtt tttttgtttg caagcagcag     2520

attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac ggggtctgac     2580

gctcagtgga acgaaaactc acgttaaggg attttggtca tgagattatc aaaaaggatc     2640

ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag tatatatgag     2700

taaacttggt ctgacagtta ccaatgctta atcagtgagg cacctatctc agcgatctgt     2760

ctatttcgtt catccatagt tgcctgactc cccgtcgtgt agataactac gatacgggag     2820

ggcttaccat ctggccccag tgctgcaatg ataccgcgag acccacgctc accggctcca     2880

gatttatcag caataaacca gccagccgga agggccgagc gcagaagtgg tcctgcaact     2940

ttatccgcct ccatccagtc tattaattgt tgccgggaag ctagagtaag tagttcgcca     3000

gttaatagtt tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc acgctcgtcg     3060

tttggtatgg cttcattcag ctccggttcc caacgatcaa ggcgagttac atgatccccc     3120

atgttgtgca aaaaagcggt tagctccttc ggtcctccga tcgttgtcag aagtaagttg     3180

gccgcagtgt tatcactcat ggttatggca gcactgcata attctcttac tgtcatgcca     3240

tccgtaagat gcttttctgt gactggtgag tactcaacca agtcattctg agaatagtgt     3300

atgcggcgac cgagttgctc ttgcccggcg tcaatacggg ataataccgc gccacatagc     3360

agaactttaa aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact ctcaaggatc     3420

ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg cacccaactg atcttcagca     3480

tcttttactt tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa tgccgcaaaa     3540

aagggaataa gggcgacacg gaaatgttga atactcatac tcttcctttt tcaatattat     3600

tgaagcattt atcagggtta ttgtctcatg agcggataca tatttgaatg tatttagaaa     3660

aataaacaaa taggggttcc gcgcacattt ccccgaaaag tgccacctga cgtctaagaa     3720

accattatta tcatgacatt aacctataaa aataggcgta tcacgaggcc ctttcgtc       3778


<210>  18
<211>  775
<212>  PRT
<213>  Thermococcus sp.

<400>  18

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asn Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Val Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Val Lys Lys Val Thr Ala Lys Arg His Gly Thr Val Val Lys 
    50                  55                  60                  


Val Lys Arg Ala Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Asn His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Arg Ile Arg Ala His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Thr Met Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Thr Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Gly Ser Glu Ala Arg Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Arg Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Glu Leu Gly Ile Lys Phe Thr Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Ser Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Lys Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg Gly Gly Tyr 
    370                 375                 380                 


Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Asp Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Ile Lys 
    450                 455                 460                 


Arg Lys Met Lys Ala Thr Val Asp Pro Leu Glu Lys Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Phe Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Met Val Ile Arg Glu Leu 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Leu 
    530                 535                 540                 


His Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Lys Glu Phe Leu Lys Tyr Ile Asn Pro Lys Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Arg Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Ala Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Thr Lys His Arg Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Lys Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Lys Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Val Lys Gly Lys Lys 
    770                 775 


<210>  19
<211>  774
<212>  PRT
<213>  Thermococcus litoralis

<400>  19

Met Ile Leu Asp Thr Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro 
            20                  25                  30          


His Phe Gln Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Ile Lys Ala Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg 
    50                  55                  60                  


Val Leu Asp Ala Val Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Ile Phe Glu His Pro Gln Asp Val Pro Ala Met 
                85                  90                  95      


Arg Gly Lys Ile Arg Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Phe Tyr His Glu Gly Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Val Gln Val Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Val Arg Leu Val Leu Gly Arg Asp Lys Glu His Pro Glu 
225                 230                 235                 240 


Pro Lys Ile Gln Arg Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly 
                245                 250                 255     


Arg Ile His Phe Asp Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu 
            260                 265                 270         


Pro Thr Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr 
        275                 280                 285             


Lys Ser Lys Leu Gly Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu 
    290                 295                 300                 


Glu Ser Met Lys Lys Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala 
305                 310                 315                 320 


Thr Tyr Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala 
                325                 330                 335     


Lys Leu Ile Gly Gln Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly 
            340                 345                 350         


Asn Leu Val Glu Trp Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu 
        355                 360                 365             


Leu Ala Pro Asn Lys Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg 
    370                 375                 380                 


Thr Thr Tyr Leu Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp 
385                 390                 395                 400 


Glu Asn Ile Ile Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile 
                405                 410                 415     


Val Thr His Asn Val Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Lys 
            420                 425                 430         


Asn Tyr Asp Val Ala Pro Ile Val Gly Tyr Arg Phe Cys Lys Asp Phe 
        435                 440                 445             


Pro Gly Phe Ile Pro Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln 
    450                 455                 460                 


Asp Ile Lys Lys Lys Met Lys Ser Thr Ile Asp Pro Ile Glu Lys Lys 
465                 470                 475                 480 


Met Leu Asp Tyr Arg Gln Arg Ala Ile Lys Leu Leu Ala Asn Ser Tyr 
                485                 490                 495     


Tyr Gly Tyr Met Gly Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys 
            500                 505                 510         


Ala Glu Ser Val Thr Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile 
        515                 520                 525             


Arg Glu Ile Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr 
    530                 535                 540                 


Asp Gly Phe Tyr Ala Thr Ile Pro Gly Glu Lys Pro Glu Leu Ile Lys 
545                 550                 555                 560 


Lys Lys Ala Lys Glu Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly 
                565                 570                 575     


Leu Leu Glu Leu Glu Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val 
            580                 585                 590         


Thr Lys Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr 
        595                 600                 605             


Arg Gly Leu Glu Val Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu 
    610                 615                 620                 


Thr Gln Ala Lys Val Leu Glu Ala Ile Leu Lys Glu Gly Ser Val Glu 
625                 630                 635                 640 


Lys Ala Val Glu Val Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr 
                645                 650                 655     


Arg Val Pro Leu Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp 
            660                 665                 670         


Leu Lys Asp Tyr Lys Ala Ile Gly Pro His Val Ala Ile Ala Lys Arg 
        675                 680                 685             


Leu Ala Ala Arg Gly Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr 
    690                 695                 700                 


Ile Val Leu Lys Gly Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu 
705                 710                 715                 720 


Thr Glu Tyr Asp Pro Arg Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile 
                725                 730                 735     


Glu Asn Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly 
            740                 745                 750         


Tyr Arg Lys Glu Asp Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu 
        755                 760                 765             


Asp Ala Trp Leu Lys Arg 
    770                 


<210>  20
<211>  776
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric DNA polymerase 9Nli

<400>  20

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asn Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Val Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Tyr Asp Arg 
            20                  25                  30          


Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Val Lys Lys Val Thr Ala Lys Arg His Gly Thr Val Val Lys 
    50                  55                  60                  


Val Lys Arg Ala Glu Lys Val Gln Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Asn His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Arg Ile Arg Ala His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Thr Met Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Thr Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Gly Ser Glu Ala Arg Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Arg Val Val Arg Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Cys Glu 
    210                 215                 220                 


Glu Leu Gly Ile Lys Phe Thr Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Ser Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Tyr Leu Leu Arg Val Ala Tyr Ala Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Glu Glu Tyr Lys Arg Arg Leu Arg Thr Thr 
    370                 375                 380                 


Tyr Leu Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn 
385                 390                 395                 400 


Ile Ile Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Val Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Glu Lys Glu Gly Cys Lys Asn Tyr 
            420                 425                 430         


Asp Val Ala Pro Ile Val Gly Tyr Arg Phe Cys Lys Asp Phe Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Ile Leu Gly Asp Leu Ile Ala Met Arg Gln Asp Ile 
    450                 455                 460                 


Lys Lys Lys Met Lys Ser Thr Ile Asp Pro Ile Glu Lys Lys Met Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Arg Ala Ile Lys Leu Leu Ala Asn Ser Tyr Tyr Gly 
                485                 490                 495     


Tyr Met Gly Tyr Pro Lys Ala Arg Trp Tyr Ser Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg His Tyr Ile Glu Met Thr Ile Arg Glu 
        515                 520                 525             


Ile Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly 
    530                 535                 540                 


Phe Tyr Ala Thr Ile Pro Gly Glu Lys Pro Glu Leu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Lys Glu Phe Leu Asn Tyr Ile Asn Ser Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala 
625                 630                 635                 640 


Val Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val 
                645                 650                 655     


Pro Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu Arg 
            660                 665                 670         


Asp Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala 
        675                 680                 685             


Ala Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val 
    690                 695                 700                 


Leu Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Ala Asp Glu 
705                 710                 715                 720 


Phe Asp Pro Thr Lys His Arg Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Glu Arg Ile Leu Lys Ala Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Tyr Gln Lys Thr Lys Gln Val Gly Leu Gly Ala 
        755                 760                 765             


Trp Leu Lys Val Lys Gly Lys Lys 
    770                 775     


<210>  21
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric DNA polymerase Li9N

<400>  21

Met Ile Leu Asp Thr Asp Tyr Ile Thr Lys Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu Leu Asp Pro 
            20                  25                  30          


His Phe Gln Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Glu Ile Lys Ala Ile Lys Gly Glu Arg His Gly Lys Thr Val Arg 
    50                  55                  60                  


Val Leu Asp Ala Val Lys Val Arg Lys Lys Phe Leu Gly Arg Glu Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Ile Phe Glu His Pro Gln Asp Val Pro Ala Met 
                85                  90                  95      


Arg Gly Lys Ile Arg Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Phe Tyr His Glu Gly Asp Glu Phe Gly Lys Gly Glu Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Asn Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Val Gln Val Val Lys Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Leu Pro Tyr Leu Ile Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Val Arg Leu Val Leu Gly Arg Asp Lys Glu His Pro Glu 
225                 230                 235                 240 


Pro Lys Ile Gln Arg Met Gly Asp Ser Phe Ala Val Glu Ile Lys Gly 
                245                 250                 255     


Arg Ile His Phe Asp Leu Phe Pro Val Val Arg Arg Thr Ile Asn Leu 
            260                 265                 270         


Pro Thr Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Leu Gly Lys Thr 
        275                 280                 285             


Lys Ser Lys Leu Gly Ala Glu Glu Ile Ala Ala Ile Trp Glu Thr Glu 
    290                 295                 300                 


Glu Ser Met Lys Lys Leu Ala Gln Tyr Ser Met Glu Asp Ala Arg Ala 
305                 310                 315                 320 


Thr Tyr Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Glu Leu Ala 
                325                 330                 335     


Lys Leu Ile Gly Gln Ser Val Trp Asp Val Ser Arg Ser Ser Thr Gly 
            340                 345                 350         


Asn Leu Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Lys Arg Asn Glu 
        355                 360                 365             


Leu Ala Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg Gly 
    370                 375                 380                 


Gly Tyr Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Asp 
385                 390                 395                 400 


Asn Ile Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile 
                405                 410                 415     


Thr His Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys Glu 
            420                 425                 430         


Tyr Asp Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro 
        435                 440                 445             


Gly Phe Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys 
    450                 455                 460                 


Ile Lys Arg Lys Met Lys Ala Thr Val Asp Pro Leu Glu Lys Lys Leu 
465                 470                 475                 480 


Leu Asp Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Phe Tyr 
                485                 490                 495     


Gly Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala 
            500                 505                 510         


Glu Ser Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Met Val Ile Arg 
        515                 520                 525             


Glu Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp 
    530                 535                 540                 


Gly Leu His Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys 
545                 550                 555                 560 


Lys Ala Lys Glu Phe Leu Lys Tyr Ile Asn Pro Lys Leu Pro Gly Leu 
                565                 570                 575     


Leu Glu Leu Glu Tyr Glu Gly Phe Tyr Leu Arg Gly Phe Phe Val Thr 
            580                 585                 590         


Lys Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Arg Ile Thr Thr Arg 
        595                 600                 605             


Gly Leu Glu Val Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr 
    610                 615                 620                 


Gln Ala Lys Val Leu Glu Ala Ile Leu Lys Glu Gly Ser Val Glu Lys 
625                 630                 635                 640 


Ala Val Glu Val Val Arg Asp Val Val Glu Lys Ile Ala Lys Tyr Arg 
                645                 650                 655     


Val Pro Leu Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp Leu 
            660                 665                 670         


Lys Asp Tyr Lys Ala Ile Gly Pro His Val Ala Ile Ala Lys Arg Leu 
        675                 680                 685             


Ala Ala Arg Gly Ile Lys Val Lys Pro Gly Thr Ile Ile Ser Tyr Ile 
    690                 695                 700                 


Val Leu Lys Gly Ser Gly Lys Ile Ser Asp Arg Val Ile Leu Leu Thr 
705                 710                 715                 720 


Glu Tyr Asp Pro Arg Lys His Lys Tyr Asp Pro Asp Tyr Tyr Ile Glu 
                725                 730                 735     


Asn Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr 
            740                 745                 750         


Arg Lys Glu Asp Leu Arg Tyr Gln Ser Ser Lys Gln Thr Gly Leu Asp 
        755                 760                 765             


Ala Trp Leu Lys Arg 
    770             


<210>  22
<211>  773
<212>  PRT
<213>  Thermococcus sp.

<400>  22

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Asp Tyr Asp Arg 
            20                  25                  30          


Asn Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Thr Val Arg 
    50                  55                  60                  


Val Val Arg Ala Glu Lys Val Lys Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Lys Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Ser Glu 
    210                 215                 220                 


Lys Leu Gly Val Lys Phe Ile Leu Gly Arg Glu Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Thr Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg Glu Ser Tyr 
    370                 375                 380                 


Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Glu Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Val Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Phe Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Gln Tyr Ile Glu Thr Thr Ile Arg Glu Ile 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Lys Glu Phe Leu Asp Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Asp Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Ile Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Ala Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Thr 
    770             


<210>  23
<211>  773
<212>  PRT
<213>  Thermococcus sp.

<400>  23

Met Ile Leu Asp Ala Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Val Phe Lys Lys Glu Lys Gly Glu Phe Lys Ile Asp Tyr Asp Arg 
            20                  25                  30          


Asp Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Ile Lys Lys Ile Thr Ala Glu Arg His Gly Thr Thr Val Arg 
    50                  55                  60                  


Val Thr Arg Ala Glu Arg Val Lys Lys Lys Phe Leu Gly Arg Pro Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Arg Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Arg Met Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Ser Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Ile Gln Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Ser Glu 
    210                 215                 220                 


Thr Leu Gly Val Lys Phe Ile Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Thr Val Tyr Glu Ala Ile Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Arg Ala Trp Glu Ser Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Ala Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Ala Glu Ser Tyr 
    370                 375                 380                 


Ala Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Tyr Lys Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Arg Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Arg Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Val Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Val Asp Pro Ile Glu Arg Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Asn Ala Arg Trp Tyr Cys Arg Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Gln Tyr Ile Glu Thr Thr Met Arg Glu Ile 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Lys Glu Phe Leu Asn Tyr Ile Asn Pro Arg Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Arg Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Asp Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Arg Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Asp Leu Arg Asp 
            660                 665                 670         


Tyr Arg Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Ile Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Pro Gly Arg Val Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Ala Lys His Arg Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Lys Gln Ala Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Thr 
    770             


<210>  24
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric DNA polymerase GoZi

<400>  24

Met Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Asp Tyr Asp Arg 
            20                  25                  30          


Asn Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr Thr Val Arg 
    50                  55                  60                  


Val Val Arg Ala Glu Lys Val Lys Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Lys Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Ser Glu 
    210                 215                 220                 


Lys Leu Gly Val Lys Phe Ile Leu Gly Arg Glu Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Gln Ala Trp Glu Thr Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Arg Glu Ser Tyr 
    370                 375                 380                 


Ala Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Tyr Lys Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Arg Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Arg Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Val Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Val Asp Pro Ile Glu Arg Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Asn Ala Arg Trp Tyr Cys Arg Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Gln Tyr Ile Glu Thr Thr Met Arg Glu Ile 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Lys Glu Phe Leu Asp Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Asp Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Asp Leu Lys Asp 
            660                 665                 670         


Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Ile Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Ala Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Thr 
    770             


<210>  25
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric DNA polymerase ZiGo

<400>  25

Met Ile Leu Asp Ala Asp Tyr Ile Thr Glu Asp Gly Lys Pro Val Ile 
1               5                   10                  15      


Arg Val Phe Lys Lys Glu Lys Gly Glu Phe Lys Ile Asp Tyr Asp Arg 
            20                  25                  30          


Asp Phe Glu Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Glu Asp Ile Lys Lys Ile Thr Ala Glu Arg His Gly Thr Thr Val Arg 
    50                  55                  60                  


Val Thr Arg Ala Glu Arg Val Lys Lys Lys Phe Leu Gly Arg Pro Val 
65                  70                  75                  80  


Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Pro Ala Val Val Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Arg Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Arg Met Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Gly Glu Gly Pro Ile Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp Lys Asn Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Ser Val Ser Thr Glu Lys Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Ile Gln Glu Lys Asp Pro Asp Val Leu Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys Arg Ser Glu 
    210                 215                 220                 


Thr Leu Gly Val Lys Phe Ile Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Thr Val Tyr Glu Ala Ile Phe Gly Gln Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala Glu Glu Ile Ala Arg Ala Trp Glu Ser Gly Glu Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys Ala Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Lys Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Leu Ala Arg Arg Ala Glu Ser Tyr 
    370                 375                 380                 


Ala Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp Glu Asn Ile 
385                 390                 395                 400 


Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr His 
                405                 410                 415     


Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Glu Glu Tyr Asp 
            420                 425                 430         


Val Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly Phe 
        435                 440                 445             


Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln Lys Val Lys 
    450                 455                 460                 


Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Lys Lys Leu Leu Asp 
465                 470                 475                 480 


Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Phe Tyr Gly Tyr 
                485                 490                 495     


Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu Ser 
            500                 505                 510         


Val Thr Ala Trp Gly Arg Gln Tyr Ile Glu Thr Thr Ile Arg Glu Ile 
        515                 520                 525             


Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ala Asp Thr Asp Gly Phe 
    530                 535                 540                 


Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys Lys Lys Ala 
545                 550                 555                 560 


Lys Glu Phe Leu Asn Tyr Ile Asn Pro Arg Leu Pro Gly Leu Leu Glu 
                565                 570                 575     


Leu Glu Tyr Glu Gly Phe Tyr Arg Arg Gly Phe Phe Val Thr Lys Lys 
            580                 585                 590         


Lys Tyr Ala Val Ile Asp Glu Glu Asp Lys Ile Thr Thr Arg Gly Leu 
        595                 600                 605             


Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala 
    610                 615                 620                 


Arg Val Leu Glu Ala Ile Leu Lys His Gly Asp Val Glu Glu Ala Val 
625                 630                 635                 640 


Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Arg Tyr Glu Val Pro 
                645                 650                 655     


Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Asp Leu Arg Asp 
            660                 665                 670         


Tyr Arg Ala Thr Gly Pro His Val Ala Val Ala Lys Arg Leu Ala Ala 
        675                 680                 685             


Arg Gly Ile Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr Ile Val Leu 
    690                 695                 700                 


Lys Gly Pro Gly Arg Val Gly Asp Arg Ala Ile Pro Phe Asp Glu Phe 
705                 710                 715                 720 


Asp Pro Ala Lys His Arg Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln 
                725                 730                 735     


Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly Tyr Arg Lys 
            740                 745                 750         


Glu Asp Leu Arg Tyr Gln Lys Thr Lys Gln Ala Gly Leu Gly Ala Trp 
        755                 760                 765             


Leu Lys Pro Lys Thr 
    770             


<210>  26
<211>  778
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric DNA polymerase Kofu-II

<400>  26

Met Ala Ser Ala Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys 
1               5                   10                  15      


Pro Val Ile Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu 
            20                  25                  30          


Tyr Asp Arg Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp 
        35                  40                  45              


Ser Ala Ile Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr 
    50                  55                  60                  


Val Val Thr Val Lys Arg Val Glu Lys Val Gln Lys Lys Phe Leu Gly 
65                  70                  75                  80  


Arg Pro Val Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val 
                85                  90                  95      


Pro Ala Ile Arg Asp Lys Ile Arg Glu His Pro Ala Val Ile Asp Ile 
            100                 105                 110         


Tyr Glu Tyr Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly 
        115                 120                 125             


Leu Val Pro Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp 
    130                 135                 140                 


Ile Glu Thr Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile 
145                 150                 155                 160 


Leu Met Ile Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp 
                165                 170                 175     


Lys Asn Val Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Arg Glu 
            180                 185                 190         


Met Ile Lys Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val 
        195                 200                 205             


Leu Ile Thr Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys 
    210                 215                 220                 


Arg Cys Glu Lys Leu Gly Ile Asn Phe Ala Leu Gly Arg Asp Gly Ser 
225                 230                 235                 240 


Glu Pro Lys Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys 
                245                 250                 255     


Gly Arg Ile His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn 
            260                 265                 270         


Leu Pro Thr Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Gln 
        275                 280                 285             


Pro Lys Glu Lys Val Tyr Ala Glu Glu Ile Thr Thr Ala Trp Glu Thr 
    290                 295                 300                 


Gly Glu Asn Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys 
305                 310                 315                 320 


Ala Thr Tyr Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ile Gln Leu 
                325                 330                 335     


Ser Arg Leu Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr 
            340                 345                 350         


Gly Asn Leu Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn 
        355                 360                 365             


Glu Val Ala Pro Asn Lys Pro Ser Glu Glu Glu Tyr Gln Arg Arg Leu 
    370                 375                 380                 


Arg Glu Ser Tyr Thr Gly Gly Phe Val Lys Glu Pro Glu Lys Gly Leu 
385                 390                 395                 400 


Trp Glu Asn Ile Val Tyr Leu Asp Phe Arg Ala Leu Tyr Pro Ser Ile 
                405                 410                 415     


Ile Ile Thr His Asn Val Ser Pro Asp Thr Leu Asn Leu Glu Gly Cys 
            420                 425                 430         


Lys Asn Tyr Asp Ile Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp 
        435                 440                 445             


Ile Pro Gly Phe Ile Pro Ser Leu Leu Gly His Leu Leu Glu Glu Arg 
    450                 455                 460                 


Gln Lys Ile Lys Thr Lys Met Lys Glu Thr Gln Asp Pro Ile Glu Lys 
465                 470                 475                 480 


Ile Leu Leu Asp Tyr Arg Gln Lys Ala Ile Lys Leu Leu Ala Asn Ser 
                485                 490                 495     


Phe Tyr Gly Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu 
            500                 505                 510         


Cys Ala Glu Ser Val Thr Ala Trp Gly Arg Lys Tyr Ile Glu Leu Val 
        515                 520                 525             


Trp Lys Glu Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp 
    530                 535                 540                 


Thr Asp Gly Leu Tyr Ala Thr Ile Pro Gly Gly Glu Ser Glu Glu Ile 
545                 550                 555                 560 


Lys Lys Lys Ala Leu Glu Phe Val Lys Tyr Ile Asn Ser Lys Leu Pro 
                565                 570                 575     


Gly Leu Leu Glu Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe 
            580                 585                 590         


Val Thr Lys Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Lys Val Ile 
        595                 600                 605             


Thr Arg Gly Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys 
    610                 615                 620                 


Glu Thr Gln Ala Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asp Val 
625                 630                 635                 640 


Glu Lys Ala Val Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys 
                645                 650                 655     


Tyr Glu Val Pro Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg 
            660                 665                 670         


Asp Leu Lys Asp Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys 
        675                 680                 685             


Arg Leu Ala Ala Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser 
    690                 695                 700                 


Tyr Ile Val Leu Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro 
705                 710                 715                 720 


Phe Asp Glu Phe Asp Pro Thr Lys His Lys Tyr Asp Ala Glu Tyr Tyr 
                725                 730                 735     


Ile Glu Asn Gln Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe 
            740                 745                 750         


Gly Tyr Arg Lys Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly 
        755                 760                 765             


Leu Ser Ala Trp Leu Lys Pro Lys Gly Thr 
    770                 775             


<210>  27
<211>  777
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric DNA polymerase Pod-II

<400>  27

Met Ala Ser Ala Ile Leu Asp Val Asp Tyr Ile Thr Glu Glu Gly Lys 
1               5                   10                  15      


Pro Val Ile Arg Leu Phe Lys Lys Glu Asn Gly Lys Phe Lys Ile Glu 
            20                  25                  30          


His Asp Arg Thr Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Arg Asp Asp 
        35                  40                  45              


Ser Lys Ile Glu Glu Val Lys Lys Ile Thr Gly Glu Arg His Gly Lys 
    50                  55                  60                  


Ile Val Arg Ile Val Asp Val Glu Lys Val Glu Lys Lys Phe Leu Gly 
65                  70                  75                  80  


Lys Pro Ile Thr Val Trp Lys Leu Tyr Leu Glu His Pro Gln Asp Val 
                85                  90                  95      


Pro Thr Ile Arg Glu Lys Val Arg Glu His Pro Ala Val Val Asp Ile 
            100                 105                 110         


Phe Glu Tyr Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly 
        115                 120                 125             


Leu Ile Pro Met Glu Gly Glu Glu Glu Leu Lys Ile Leu Ala Phe Asp 
    130                 135                 140                 


Ile Glu Thr Leu Tyr His Glu Gly Glu Glu Phe Gly Lys Gly Pro Ile 
145                 150                 155                 160 


Ile Met Ile Ser Tyr Ala Asp Glu Asn Glu Ala Lys Val Ile Thr Trp 
                165                 170                 175     


Lys Asn Ile Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu 
            180                 185                 190         


Met Ile Lys Arg Phe Leu Arg Ile Ile Arg Glu Lys Asp Pro Asp Ile 
        195                 200                 205             


Ile Val Thr Tyr Asn Gly Asp Ser Phe Asp Phe Pro Tyr Leu Ala Lys 
    210                 215                 220                 


Arg Ala Glu Lys Leu Gly Ile Lys Leu Thr Ile Gly Arg Asp Gly Ser 
225                 230                 235                 240 


Glu Pro Lys Met Gln Arg Ile Gly Asp Met Thr Ala Val Glu Val Lys 
                245                 250                 255     


Gly Arg Ile His Phe Asp Leu Tyr His Val Ile Thr Arg Thr Ile Asn 
            260                 265                 270         


Leu Pro Thr Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys 
        275                 280                 285             


Pro Lys Glu Lys Val Tyr Ala Asp Glu Ile Ala Lys Ala Trp Glu Ser 
    290                 295                 300                 


Gly Glu Asn Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys 
305                 310                 315                 320 


Val Thr Tyr Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ala Gln Leu 
                325                 330                 335     


Ser Arg Leu Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr 
            340                 345                 350         


Gly Asn Leu Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn 
        355                 360                 365             


Glu Leu Ala Pro Asn Lys Pro Asp Glu Lys Glu Leu Ala Arg Arg Arg 
    370                 375                 380                 


Gln Ser Tyr Glu Gly Gly Tyr Val Lys Glu Pro Glu Arg Gly Leu Trp 
385                 390                 395                 400 


Glu Asn Ile Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile 
                405                 410                 415     


Ile Thr His Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Lys 
            420                 425                 430         


Glu Tyr Asp Val Ala Pro Gln Val Gly His Arg Phe Cys Lys Asp Phe 
        435                 440                 445             


Pro Gly Phe Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg Gln 
    450                 455                 460                 


Lys Ile Lys Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Arg Lys 
465                 470                 475                 480 


Leu Leu Asp Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr 
                485                 490                 495     


Tyr Gly Tyr Tyr Gly Tyr Ala Arg Ala Arg Trp Tyr Cys Lys Glu Cys 
            500                 505                 510         


Ala Glu Ser Val Thr Ala Trp Gly Arg Glu Tyr Ile Thr Met Thr Ile 
        515                 520                 525             


Lys Glu Ile Glu Glu Lys Tyr Gly Phe Lys Val Ile Tyr Ser Asp Thr 
    530                 535                 540                 


Asp Gly Phe Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val Lys 
545                 550                 555                 560 


Lys Lys Ala Met Glu Phe Leu Lys Tyr Ile Asn Ala Lys Leu Pro Gly 
                565                 570                 575     


Ala Leu Glu Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val 
            580                 585                 590         


Thr Lys Lys Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr 
        595                 600                 605             


Arg Gly Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu 
    610                 615                 620                 


Thr Gln Ala Arg Val Leu Glu Thr Ile Leu Lys His Gly Asp Val Glu 
625                 630                 635                 640 


Glu Ala Val Arg Ile Val Lys Glu Val Ile Gln Lys Leu Ala Asn Tyr 
                645                 650                 655     


Glu Ile Pro Pro Glu Lys Leu Ala Ile Tyr Glu Gln Ile Thr Arg Pro 
            660                 665                 670         


Leu His Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Lys 
        675                 680                 685             


Leu Ala Ala Lys Gly Val Lys Ile Lys Pro Gly Met Val Ile Gly Tyr 
    690                 695                 700                 


Ile Val Leu Arg Gly Asp Gly Pro Ile Ser Asn Arg Ala Ile Leu Ala 
705                 710                 715                 720 


Glu Glu Tyr Asp Pro Lys Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile 
                725                 730                 735     


Glu Asn Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Gly Phe Gly 
            740                 745                 750         


Tyr Arg Lys Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu 
        755                 760                 765             


Thr Ser Trp Leu Asn Ile Lys Lys Ser 
    770                 775         


<210>  28
<211>  777
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric DNA polymerase Kofu-III

<400>  28

Met Ala Ser Ala Ile Leu Asp Thr Asp Tyr Ile Thr Glu Asp Gly Lys 
1               5                   10                  15      


Pro Val Ile Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Ile Glu 
            20                  25                  30          


Tyr Asp Arg Thr Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp 
        35                  40                  45              


Ser Ala Ile Glu Glu Val Lys Lys Ile Thr Ala Glu Arg His Gly Thr 
    50                  55                  60                  


Val Val Thr Val Lys Arg Val Glu Lys Val Gln Lys Lys Phe Leu Gly 
65                  70                  75                  80  


Arg Pro Val Glu Val Trp Lys Leu Tyr Phe Thr His Pro Gln Asp Val 
                85                  90                  95      


Pro Ala Ile Arg Asp Lys Ile Arg Glu His Pro Ala Val Ile Asp Ile 
            100                 105                 110         


Tyr Glu Tyr Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly 
        115                 120                 125             


Leu Val Pro Met Glu Gly Asp Glu Glu Leu Lys Met Leu Ala Phe Asp 
    130                 135                 140                 


Ile Glu Thr Leu Tyr His Glu Gly Glu Glu Phe Ala Glu Gly Pro Ile 
145                 150                 155                 160 


Leu Met Ile Ser Tyr Ala Asp Glu Glu Gly Ala Arg Val Ile Thr Trp 
                165                 170                 175     


Lys Asn Val Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Arg Glu 
            180                 185                 190         


Met Ile Lys Arg Phe Leu Arg Val Val Lys Glu Lys Asp Pro Asp Val 
        195                 200                 205             


Leu Ile Thr Tyr Asn Gly Asp Asn Phe Asp Phe Ala Tyr Leu Lys Lys 
    210                 215                 220                 


Arg Cys Glu Lys Leu Gly Ile Asn Phe Ala Leu Gly Arg Asp Gly Ser 
225                 230                 235                 240 


Glu Pro Lys Ile Gln Arg Met Gly Asp Arg Phe Ala Val Glu Val Lys 
                245                 250                 255     


Gly Arg Ile His Phe Asp Leu Tyr Pro Val Ile Arg Arg Thr Ile Asn 
            260                 265                 270         


Leu Pro Thr Tyr Thr Leu Glu Ala Val Tyr Glu Ala Val Phe Gly Gln 
        275                 280                 285             


Pro Lys Glu Lys Val Tyr Ala Glu Glu Ile Thr Thr Ala Trp Glu Thr 
    290                 295                 300                 


Gly Glu Asn Leu Glu Arg Val Ala Arg Tyr Ser Met Glu Asp Ala Lys 
305                 310                 315                 320 


Val Thr Tyr Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ala Gln Leu 
                325                 330                 335     


Ser Arg Leu Ile Gly Gln Ser Leu Trp Asp Val Ser Arg Ser Ser Thr 
            340                 345                 350         


Gly Asn Leu Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn 
        355                 360                 365             


Glu Leu Ala Pro Asn Lys Pro Asp Glu Lys Glu Leu Ala Arg Arg Arg 
    370                 375                 380                 


Gln Ser Tyr Glu Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp 
385                 390                 395                 400 


Glu Asn Ile Val Tyr Leu Asp Phe Arg Ala Leu Tyr Pro Ser Ile Ile 
                405                 410                 415     


Ile Thr His Asn Val Ser Pro Asp Thr Leu Asn Leu Glu Gly Cys Lys 
            420                 425                 430         


Asn Tyr Asp Ile Ala Pro Gln Val Gly His Lys Phe Cys Lys Asp Ile 
        435                 440                 445             


Pro Gly Phe Ile Pro Ser Leu Leu Gly His Leu Leu Glu Glu Arg Gln 
    450                 455                 460                 


Lys Ile Lys Thr Lys Met Lys Glu Thr Gln Asp Pro Ile Glu Lys Ile 
465                 470                 475                 480 


Leu Leu Asp Tyr Arg Gln Lys Ala Ile Lys Leu Leu Ala Asn Ser Phe 
                485                 490                 495     


Tyr Gly Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys 
            500                 505                 510         


Ala Glu Ser Val Thr Ala Trp Gly Arg Lys Tyr Ile Glu Leu Val Trp 
        515                 520                 525             


Lys Glu Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr 
    530                 535                 540                 


Asp Gly Leu Tyr Ala Thr Ile Pro Gly Gly Glu Ser Glu Glu Ile Lys 
545                 550                 555                 560 


Lys Lys Ala Leu Glu Phe Leu Lys Tyr Ile Asn Ala Lys Leu Pro Gly 
                565                 570                 575     


Ala Leu Glu Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe Val 
            580                 585                 590         


Thr Lys Lys Lys Tyr Ala Val Ile Asp Glu Glu Gly Lys Ile Thr Thr 
        595                 600                 605             


Arg Gly Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu 
    610                 615                 620                 


Thr Gln Ala Arg Val Leu Glu Ala Leu Leu Lys Asp Gly Asp Val Glu 
625                 630                 635                 640 


Lys Ala Val Arg Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr 
                645                 650                 655     


Glu Val Pro Pro Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp 
            660                 665                 670         


Leu Lys Asp Tyr Lys Ala Thr Gly Pro His Val Ala Val Ala Lys Arg 
        675                 680                 685             


Leu Ala Ala Arg Gly Val Lys Ile Arg Pro Gly Thr Val Ile Ser Tyr 
    690                 695                 700                 


Ile Val Leu Lys Gly Ser Gly Arg Ile Gly Asp Arg Ala Ile Pro Phe 
705                 710                 715                 720 


Asp Glu Phe Asp Pro Thr Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile 
                725                 730                 735     


Glu Asn Gln Val Leu Pro Ala Val Glu Arg Ile Leu Arg Ala Phe Gly 
            740                 745                 750         


Tyr Arg Lys Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly Leu 
        755                 760                 765             


Ser Ala Trp Leu Lys Pro Lys Gly Thr 
    770                 775         


<210>  29
<211>  778
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric DNA polymerase Pod-III

<400>  29

Met Ala Ser Ala Ile Leu Asp Val Asp Tyr Ile Thr Glu Glu Gly Lys 
1               5                   10                  15      


Pro Val Ile Arg Leu Phe Lys Lys Glu Asn Gly Lys Phe Lys Ile Glu 
            20                  25                  30          


His Asp Arg Thr Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Arg Asp Asp 
        35                  40                  45              


Ser Lys Ile Glu Glu Val Lys Lys Ile Thr Gly Glu Arg His Gly Lys 
    50                  55                  60                  


Ile Val Arg Ile Val Asp Val Glu Lys Val Glu Lys Lys Phe Leu Gly 
65                  70                  75                  80  


Lys Pro Ile Thr Val Trp Lys Leu Tyr Leu Glu His Pro Gln Asp Val 
                85                  90                  95      


Pro Thr Ile Arg Glu Lys Val Arg Glu His Pro Ala Val Val Asp Ile 
            100                 105                 110         


Phe Glu Tyr Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly 
        115                 120                 125             


Leu Ile Pro Met Glu Gly Glu Glu Glu Leu Lys Ile Leu Ala Phe Asp 
    130                 135                 140                 


Ile Glu Thr Leu Tyr His Glu Gly Glu Glu Phe Gly Lys Gly Pro Ile 
145                 150                 155                 160 


Ile Met Ile Ser Tyr Ala Asp Glu Asn Glu Ala Lys Val Ile Thr Trp 
                165                 170                 175     


Lys Asn Ile Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu 
            180                 185                 190         


Met Ile Lys Arg Phe Leu Arg Ile Ile Arg Glu Lys Asp Pro Asp Ile 
        195                 200                 205             


Ile Val Thr Tyr Asn Gly Asp Ser Phe Asp Phe Pro Tyr Leu Ala Lys 
    210                 215                 220                 


Arg Ala Glu Lys Leu Gly Ile Lys Leu Thr Ile Gly Arg Asp Gly Ser 
225                 230                 235                 240 


Glu Pro Lys Met Gln Arg Ile Gly Asp Met Thr Ala Val Glu Val Lys 
                245                 250                 255     


Gly Arg Ile His Phe Asp Leu Tyr His Val Ile Thr Arg Thr Ile Asn 
            260                 265                 270         


Leu Pro Thr Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys 
        275                 280                 285             


Pro Lys Glu Lys Val Tyr Ala Asp Glu Ile Ala Lys Ala Trp Glu Ser 
    290                 295                 300                 


Gly Glu Asn Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys 
305                 310                 315                 320 


Ala Thr Tyr Glu Leu Gly Lys Glu Phe Leu Pro Met Glu Ile Gln Leu 
                325                 330                 335     


Ser Arg Leu Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr 
            340                 345                 350         


Gly Asn Leu Val Glu Trp Phe Leu Leu Arg Lys Ala Tyr Glu Arg Asn 
        355                 360                 365             


Glu Val Ala Pro Asn Lys Pro Ser Glu Glu Glu Tyr Gln Arg Arg Leu 
    370                 375                 380                 


Arg Glu Ser Tyr Thr Gly Gly Phe Val Lys Glu Pro Glu Arg Gly Leu 
385                 390                 395                 400 


Trp Glu Asn Ile Val Tyr Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile 
                405                 410                 415     


Ile Ile Thr His Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys 
            420                 425                 430         


Lys Glu Tyr Asp Val Ala Pro Gln Val Gly His Arg Phe Cys Lys Asp 
        435                 440                 445             


Phe Pro Gly Phe Ile Pro Ser Leu Leu Gly Asp Leu Leu Glu Glu Arg 
    450                 455                 460                 


Gln Lys Ile Lys Lys Lys Met Lys Ala Thr Ile Asp Pro Ile Glu Arg 
465                 470                 475                 480 


Lys Leu Leu Asp Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser 
                485                 490                 495     


Tyr Tyr Gly Tyr Tyr Gly Tyr Ala Arg Ala Arg Trp Tyr Cys Lys Glu 
            500                 505                 510         


Cys Ala Glu Ser Val Thr Ala Trp Gly Arg Glu Tyr Ile Thr Met Thr 
        515                 520                 525             


Ile Lys Glu Ile Glu Glu Lys Tyr Gly Phe Lys Val Ile Tyr Ser Asp 
    530                 535                 540                 


Thr Asp Gly Phe Phe Ala Thr Ile Pro Gly Ala Asp Ala Glu Thr Val 
545                 550                 555                 560 


Lys Lys Lys Ala Met Glu Phe Val Lys Tyr Ile Asn Ser Lys Leu Pro 
                565                 570                 575     


Gly Leu Leu Glu Leu Glu Tyr Glu Gly Phe Tyr Lys Arg Gly Phe Phe 
            580                 585                 590         


Val Thr Lys Lys Arg Tyr Ala Val Ile Asp Glu Glu Gly Lys Val Ile 
        595                 600                 605             


Thr Arg Gly Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys 
    610                 615                 620                 


Glu Thr Gln Ala Arg Val Leu Glu Thr Ile Leu Lys His Gly Asp Val 
625                 630                 635                 640 


Glu Glu Ala Val Arg Ile Val Lys Glu Val Ile Gln Lys Leu Ala Asn 
                645                 650                 655     


Tyr Glu Ile Pro Pro Glu Lys Leu Ala Ile Tyr Glu Gln Ile Thr Arg 
            660                 665                 670         


Pro Leu His Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys 
        675                 680                 685             


Lys Leu Ala Ala Lys Gly Val Lys Ile Lys Pro Gly Met Val Ile Gly 
    690                 695                 700                 


Tyr Ile Val Leu Arg Gly Asp Gly Pro Ile Ser Asn Arg Ala Ile Leu 
705                 710                 715                 720 


Ala Glu Glu Tyr Asp Pro Lys Lys His Lys Tyr Asp Ala Glu Tyr Tyr 
                725                 730                 735     


Ile Glu Asn Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Gly Phe 
            740                 745                 750         


Gly Tyr Arg Lys Glu Asp Leu Arg Tyr Gln Lys Thr Arg Gln Val Gly 
        755                 760                 765             


Leu Thr Ser Trp Leu Asn Ile Lys Lys Ser 
    770                 775             


<210>  30
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus Sequence


<220>
<221>  Xaa
<222>  (1)..(2)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (4)..(10)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (13)..(13)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (15)..(20)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (22)..(26)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (28)..(30)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (32)..(41)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (44)..(49)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (53)..(57)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (59)..(61)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (63)..(64)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (66)..(67)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (69)..(73)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (78)..(89)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (91)..(92)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (94)..(95)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (98)..(110)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (112)..(113)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (115)..(130)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (132)..(133)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (135)..(141)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (143)..(144)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (147)..(149)
<223>  Xaa is any amino acid or a peptide bond

<400>  30

Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu Gly Xaa Arg Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Val Xaa Xaa Xaa Xaa Xaa Asp Xaa Xaa Xaa Thr Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Val Val Lys Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Val Leu Ile Xaa Xaa Xaa Xaa Xaa Asn Xaa Xaa Xaa Ala Xaa Xaa 
    50                  55                  60                  


Lys Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Asn Phe Ala Leu Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Xaa Xaa Met Xaa Xaa Arg 
                85                  90                  95      


Phe Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Pro Xaa 
            100                 105                 110         


Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Val Xaa Xaa Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu Xaa Xaa 
    130                 135                 140                 


Thr Thr Xaa Xaa Xaa Thr 
145                 150 


<210>  31
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus Sequence


<220>
<221>  Xaa
<222>  (1)..(2)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (4)..(7)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (9)..(12)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (14)..(15)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (17)..(20)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (22)..(24)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (26)..(33)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (35)..(38)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (41)..(41)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (46)..(49)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (51)..(55)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (57)..(57)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (60)..(64)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (67)..(72)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (74)..(75)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (77)..(77)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (79)..(83)
<223>  Xaa is any amino acid or a peptide bond

<400>  31

Xaa Xaa Glu Xaa Xaa Xaa Xaa Tyr Xaa Xaa Xaa Xaa Glu Xaa Xaa Phe 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Lys Xaa Xaa Xaa Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Ala Xaa Xaa Xaa Xaa Thr Val Xaa Thr Val Lys Arg Xaa Xaa Xaa 
        35                  40                  45              


Xaa Gln Xaa Xaa Xaa Xaa Xaa Arg Xaa Val Glu Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Phe Thr Xaa Xaa Xaa Xaa Xaa Xaa Ala Xaa Xaa Asp Xaa Ile Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa 
            


<210>  32
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus Sequence


<220>
<221>  Xaa
<222>  (1)..(16)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (19)..(20)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (22)..(25)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (27)..(34)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (37)..(38)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (41)..(42)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (44)..(48)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (50)..(50)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (52)..(56)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (58)..(58)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (61)..(63)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (65)..(72)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (74)..(76)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (78)..(81)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (83)..(84)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (86)..(87)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (88)..(92)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (94)..(94)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (96)..(96)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (98)..(98)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (101)..(103)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (107)..(107)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (109)..(110)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (112)..(129)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (131)..(133)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (136)..(137)
<223>  Xaa is any amino acid or a peptide bond

<400>  32

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Ala Leu Xaa Xaa Asp Xaa Xaa Xaa Xaa Lys Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Thr Glu Xaa Xaa Ser Lys Xaa Xaa Val Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Val Xaa His Xaa Xaa Xaa Xaa Xaa Asp Xaa Lys Asp Xaa Xaa Xaa Thr 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Xaa Xaa Xaa Arg Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Arg Xaa Xaa Thr Xaa Xaa Ser Xaa Xaa Xaa Xaa Lys Xaa Ser Xaa 
                85                  90                  95      


Arg Xaa Gly Asp Xaa Xaa Xaa Pro Phe Asp Xaa Phe Xaa Xaa Thr Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Glu Xaa Xaa Xaa Arg Ala Xaa Xaa 
    130                 135         


<210>  33
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus Sequence


<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is any amino acid or a peptide bond, but not K

<220>
<221>  Xaa
<222>  (8)..(8)
<223>  Xaa is any amino acid or a peptide bond, but not H

<220>
<221>  Xaa
<222>  (13)..(13)
<223>  Xaa is any amino acid or a peptide bond, but not R

<220>
<221>  Xaa
<222>  (16)..(16)
<223>  Xaa is any amino acid or a peptide bond, but not I

<220>
<221>  Xaa
<222>  (21)..(21)
<223>  Xaa is any amino acid or a peptide bond, but not R

<220>
<221>  Xaa
<222>  (25)..(25)
<223>  Xaa is any amino acid or a peptide bond, but not K

<220>
<221>  Xaa
<222>  (34)..(34)
<223>  Xaa is any amino acid or a peptide bond, but not G

<220>
<221>  Xaa
<222>  (39)..(39)
<223>  Xaa is any amino acid or a peptide bond, but not K

<220>
<221>  Xaa
<222>  (40)..(40)
<223>  Xaa is any amino acid or a peptide bond, but not I

<220>
<221>  Xaa
<222>  (42)..(42)
<223>  Xaa is any amino acid or a peptide bond, but not R

<220>
<221>  Xaa
<222>  (43)..(43)
<223>  Xaa is any amino acid or a peptide bond, but not I

<220>
<221>  Xaa
<222>  (44)..(44)
<223>  Xaa is any amino acid or a peptide bond, but not V

<220>
<221>  Xaa
<222>  (45)..(45)
<223>  Xaa is any amino acid or a peptide bond, but not D

<220>
<221>  Xaa
<222>  (50)..(50)
<223>  Xaa is any amino acid or a peptide bond, but not E

<220>
<221>  Xaa
<222>  (56)..(56)
<223>  Xaa is any amino acid or a peptide bond, but not K

<220>
<221>  Xaa
<222>  (58)..(58)
<223>  Xaa is any amino acid or a peptide bond, but not I

<220>
<221>  Xaa
<222>  (59)..(59)
<223>  Xaa is any amino acid or a peptide bond, but not T

<220>
<221>  Xaa
<222>  (65)..(65)
<223>  Xaa is any amino acid or a peptide bond, but not L

<220>
<221>  Xaa
<222>  (66)..(66)
<223>  Xaa is any amino acid or a peptide bond, but not E

<220>
<221>  Xaa
<222>  (73)..(73)
<223>  Xaa is any amino acid or a peptide bond, but not T

<220>
<221>  Xaa
<222>  (76)..(76)
<223>  Xaa is any amino acid or a peptide bond, but not E

<220>
<221>  Xaa
<222>  (78)..(78)
<223>  Xaa is any amino acid or a peptide bond, but not V

<400>  33

Asn Gly Xaa Phe Lys Ile Glu Xaa Asp Arg Thr Phe Xaa Pro Tyr Xaa 
1               5                   10                  15      


Tyr Ala Leu Leu Xaa Asp Asp Ser Xaa Ile Glu Glu Val Lys Lys Ile 
            20                  25                  30          


Thr Xaa Glu Arg His Gly Xaa Xaa Val Xaa Xaa Xaa Xaa Val Glu Lys 
        35                  40                  45              


Val Xaa Lys Lys Phe Leu Gly Xaa Pro Xaa Xaa Val Trp Lys Leu Tyr 
    50                  55                  60                  


Xaa Xaa His Pro Gln Asp Val Pro Xaa Ile Arg Xaa Lys Xaa Arg Glu 
65                  70                  75                  80  


His Pro Ala 
            


<210>  34
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus Sequence


<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is any amino acid or a peptide bond, but not I

<220>
<221>  Xaa
<222>  (11)..(11)
<223>  Xaa is any amino acid or a peptide bond, but not N

<220>
<221>  Xaa
<222>  (12)..(12)
<223>  Xaa is any amino acid or a peptide bond, but not E

<220>
<221>  Xaa
<222>  (14)..(14)
<223>  Xaa is any amino acid or a peptide bond, but not K

<220>
<221>  Xaa
<222>  (21)..(21)
<223>  Xaa is any amino acid or a peptide bond, but not I

<220>
<221>  Xaa
<222>  (27)..(27)
<223>  Xaa is any amino acid or a peptide bond, but not E

<220>
<221>  Xaa
<222>  (31)..(31)
<223>  Xaa is any amino acid or a peptide bond, but not S

<220>
<221>  Xaa
<222>  (42)..(42)
<223>  Xaa is any amino acid or a peptide bond, but not I

<220>
<221>  Xaa
<222>  (43)..(43)
<223>  Xaa is any amino acid or a peptide bond, but not I

<220>
<221>  Xaa
<222>  (44)..(44)
<223>  Xaa is any amino acid or a peptide bond, but not R

<220>
<221>  Xaa
<222>  (50)..(50)
<223>  Xaa is any amino acid or a peptide bond, but not I

<220>
<221>  Xaa
<222>  (51)..(51)
<223>  Xaa is any amino acid or a peptide bond, but not I

<220>
<221>  Xaa
<222>  (52)..(52)
<223>  Xaa is any amino acid or a peptide bond, but not V

<220>
<221>  Xaa
<222>  (58)..(58)
<223>  Xaa is any amino acid or a peptide bond, but not S

<220>
<221>  Xaa
<222>  (62)..(62)
<223>  Xaa is any amino acid or a peptide bond, but not P

<220>
<221>  Xaa
<222>  (65)..(65)
<223>  Xaa is any amino acid or a peptide bond, but not A

<220>
<221>  Xaa
<222>  (68)..(68)
<223>  Xaa is any amino acid or a peptide bond, but not A

<220>
<221>  Xaa
<222>  (74)..(74)
<223>  Xaa is any amino acid or a peptide bond, but not K

<220>
<221>  Xaa
<222>  (75)..(75)
<223>  Xaa is any amino acid or a peptide bond, but not L

<220>
<221>  Xaa
<222>  (76)..(76)
<223>  Xaa is any amino acid or a peptide bond, but not T

<220>
<221>  Xaa
<222>  (77)..(77)
<223>  Xaa is any amino acid or a peptide bond, but not I

<220>
<221>  Xaa
<222>  (86)..(86)
<223>  Xaa is any amino acid or a peptide bond, but not M

<220>
<221>  Xaa
<222>  (89)..(89)
<223>  Xaa is any amino acid or a peptide bond, but not I

<220>
<221>  Xaa
<222>  (92)..(92)
<223>  Xaa is any amino acid or a peptide bond, but not M

<220>
<221>  Xaa
<222>  (93)..(93)
<223>  Xaa is any amino acid or a peptide bond, but not T

<220>
<221>  Xaa
<222>  (107)..(107)
<223>  Xaa is any amino acid or a peptide bond, but not H

<220>
<221>  Xaa
<222>  (110)..(110)
<223>  Xaa is any amino acid or a peptide bond, but not T

<220>
<221>  Xaa
<222>  (127)..(127)
<223>  Xaa is any amino acid or a peptide bond, but not I

<220>
<221>  Xaa
<222>  (130)..(130)
<223>  Xaa is any amino acid or a peptide bond, but not K

<220>
<221>  Xaa
<222>  (138)..(138)
<223>  Xaa is any amino acid or a peptide bond, but not D

<220>
<221>  Xaa
<222>  (141)..(141)
<223>  Xaa is any amino acid or a peptide bond, but not A

<220>
<221>  Xaa
<222>  (142)..(142)
<223>  Xaa is any amino acid or a peptide bond, but not K

<220>
<221>  Xaa
<222>  (146)..(146)
<223>  Xaa is any amino acid or a peptide bond, but not S

<400>  34

Pro Ile Xaa Met Ile Ser Tyr Ala Asp Glu Xaa Xaa Ala Xaa Val Ile 
1               5                   10                  15      


Thr Trp Lys Asn Xaa Asp Leu Pro Tyr Val Xaa Val Val Ser Xaa Glu 
            20                  25                  30          


Arg Glu Met Ile Lys Arg Phe Leu Arg Xaa Xaa Xaa Glu Lys Asp Pro 
        35                  40                  45              


Asp Xaa Xaa Xaa Thr Tyr Asn Gly Asp Xaa Phe Asp Phe Xaa Tyr Leu 
    50                  55                  60                  


Xaa Lys Arg Xaa Glu Lys Leu Gly Ile Xaa Xaa Xaa Xaa Gly Arg Asp 
65                  70                  75                  80  


Gly Ser Glu Pro Lys Xaa Gln Arg Xaa Gly Asp Xaa Xaa Ala Val Glu 
                85                  90                  95      


Val Lys Gly Arg Ile His Phe Asp Leu Tyr Xaa Val Ile Xaa Arg Thr 
            100                 105                 110         


Ile Asn Leu Pro Thr Tyr Thr Leu Glu Ala Val Tyr Glu Ala Xaa Phe 
        115                 120                 125             


Gly Xaa Pro Lys Glu Lys Val Tyr Ala Xaa Glu Ile Xaa Xaa Ala Trp 
    130                 135                 140                 


Glu Xaa 
145     


<210>  35
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus Sequence


<220>
<221>  Xaa
<222>  (17)..(17)
<223>  Xaa is any amino acid or a peptide bond, but not T

<220>
<221>  Xaa
<222>  (18)..(18)
<223>  Xaa is any amino acid or a peptide bond, but not I

<220>
<221>  Xaa
<222>  (21)..(21)
<223>  Xaa is any amino acid or a peptide bond, but not H

<220>
<221>  Xaa
<222>  (26)..(26)
<223>  Xaa is any amino acid or a peptide bond, but not E

<220>
<221>  Xaa
<222>  (35)..(35)
<223>  Xaa is any amino acid or a peptide bond, but not I

<220>
<221>  Xaa
<222>  (36)..(36)
<223>  Xaa is any amino acid or a peptide bond, but not Q

<220>
<221>  Xaa
<222>  (39)..(39)
<223>  Xaa is any amino acid or a peptide bond, but not A

<220>
<221>  Xaa
<222>  (40)..(40)
<223>  Xaa is any amino acid or a peptide bond, but not N

<220>
<221>  Xaa
<222>  (43)..(43)
<223>  Xaa is any amino acid or a peptide bond, but not I

<220>
<221>  Xaa
<222>  (49)..(49)
<223>  Xaa is any amino acid or a peptide bond, but not A

<220>
<221>  Xaa
<222>  (51)..(51)
<223>  Xaa is any amino acid or a peptide bond, but not Y

<220>
<221>  Xaa
<222>  (57)..(57)
<223>  Xaa is any amino acid or a peptide bond, but not P

<220>
<221>  Xaa
<222>  (59)..(59)
<223>  Xaa is any amino acid or a peptide bond, but not H

<220>
<221>  Xaa
<222>  (60)..(60)
<223>  Xaa is any amino acid or a peptide bond, but not E

<220>
<221>  Xaa
<222>  (64)..(64)
<223>  Xaa is any amino acid or a peptide bond, but not I

<220>
<221>  Xaa
<222>  (73)..(73)
<223>  Xaa is any amino acid or a peptide bond, but not K

<220>
<221>  Xaa
<222>  (77)..(77)
<223>  Xaa is any amino acid or a peptide bond, but not K

<220>
<221>  Xaa
<222>  (82)..(82)
<223>  Xaa is any amino acid or a peptide bond, but not K

<220>
<221>  Xaa
<222>  (85)..(85)
<223>  Xaa is any amino acid or a peptide bond, but not M

<220>
<221>  Xaa
<222>  (88)..(88)
<223>  Xaa is any amino acid or a peptide bond, but not G

<220>
<221>  Xaa
<222>  (93)..(93)
<223>  Xaa is any amino acid or a peptide bond, but not R

<220>
<221>  Xaa
<222>  (95)..(95)
<223>  Xaa is any amino acid or a peptide bond, but not D

<220>
<221>  Xaa
<222>  (97)..(97)
<223>  Xaa is any amino acid or a peptide bond, but not P

<220>
<221>  Xaa
<222>  (99)..(99)
<223>  Xaa is any amino acid or a peptide bond, but not S

<220>
<221>  Xaa
<222>  (100)..(100)
<223>  Xaa is any amino acid or a peptide bond, but not N

<220>
<221>  Xaa
<222>  (104)..(104)
<223>  Xaa is any amino acid or a peptide bond, but not L

<220>
<221>  Xaa
<222>  (105)..(105)
<223>  Xaa is any amino acid or a peptide bond, but not A

<220>
<221>  Xaa
<222>  (106)..(106)
<223>  Xaa is any amino acid or a peptide bond, but not E

<220>
<221>  Xaa
<222>  (108)..(108)
<223>  Xaa is any amino acid or a peptide bond, but not Y

<220>
<221>  Xaa
<222>  (111)..(111)
<223>  Xaa is any amino acid or a peptide bond, but not K

<220>
<221>  Xaa
<222>  (130)..(130)
<223>  Xaa is any amino acid or a peptide bond, but not L

<220>
<221>  Xaa
<222>  (134)..(134)
<223>  Xaa is any amino acid or a peptide bond, but not E

<220>
<221>  Xaa
<222>  (135)..(135)
<223>  Xaa is any amino acid or a peptide bond, but not G

<400>  35

Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln Ala Arg Val Leu Glu 
1               5                   10                  15      


Xaa Xaa Leu Lys Xaa Gly Asp Val Glu Xaa Ala Val Arg Ile Val Lys 
            20                  25                  30          


Glu Val Xaa Xaa Lys Leu Xaa Xaa Tyr Glu Xaa Pro Pro Glu Lys Leu 
        35                  40                  45              


Xaa Ile Xaa Glu Gln Ile Thr Arg Xaa Leu Xaa Xaa Tyr Lys Ala Xaa 
    50                  55                  60                  


Gly Pro His Val Ala Val Ala Lys Xaa Leu Ala Ala Xaa Gly Val Lys 
65                  70                  75                  80  


Ile Xaa Pro Gly Xaa Val Ile Xaa Tyr Ile Val Leu Xaa Gly Xaa Gly 
                85                  90                  95      


Xaa Ile Xaa Xaa Arg Ala Ile Xaa Xaa Xaa Glu Xaa Asp Pro Xaa Lys 
            100                 105                 110         


His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn Gln Val Leu Pro Ala 
        115                 120                 125             


Val Xaa Arg Ile Leu Xaa Xaa Phe Gly 
    130                 135         


<210>  36
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus Sequence


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (3)..(14)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (16)..(32)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (34)..(37)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (39)..(40)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (42)..(47)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (49)..(52)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (54)..(62)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (64)..(72)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (74)..(76)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (78)..(78)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (80)..(83)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (86)..(91)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (93)..(95)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (97)..(100)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (102)..(108)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (110)..(126)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (128)..(129)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (134)..(135)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (137)..(139)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (141)..(144)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (146)..(146)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (148)..(151)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (154)..(158)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (162)..(162)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (165)..(168)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (170)..(170)
<223>  Xaa is any amino acid or a peptide bond

<400>  36

Xaa Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Leu Xaa Xaa Xaa Xaa Asn Xaa Xaa Ile Xaa Xaa Xaa Xaa Xaa Xaa Lys 
        35                  40                  45              


Xaa Xaa Xaa Xaa Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Thr Xaa Xaa Xaa Glu Xaa Gln Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Lys Ile Xaa Xaa Xaa Xaa Xaa Xaa Lys Xaa Xaa Xaa Leu 
                85                  90                  95      


Xaa Xaa Xaa Xaa Phe Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Xaa 
        115                 120                 125             


Xaa Glu Leu Val Trp Xaa Xaa Leu Xaa Xaa Xaa Phe Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Leu Xaa Ile Xaa Xaa Xaa Xaa Leu Tyr Xaa Xaa Xaa Xaa Xaa Gly Glu 
145                 150                 155                 160 


Ser Xaa Glu Ile Xaa Xaa Xaa Xaa Leu Xaa 
                165                 170 


<210>  37
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus Sequence


<220>
<221>  Xaa
<222>  (2)..(2)
<223>  Xaa is any amino acid or a peptide bond, but not R

<220>
<221>  Xaa
<222>  (15)..(15)
<223>  Xaa is any amino acid or a peptide bond, but not S

<220>
<221>  Xaa
<222>  (33)..(33)
<223>  Xaa is any amino acid or a peptide bond, but not R

<220>
<221>  Xaa
<222>  (38)..(38)
<223>  Xaa is any amino acid or a peptide bond, but not E

<220>
<221>  Xaa
<222>  (41)..(41)
<223>  Xaa is any amino acid or a peptide bond, but not V

<220>
<221>  Xaa
<222>  (48)..(48)
<223>  Xaa is any amino acid or a peptide bond, but not R

<220>
<221>  Xaa
<222>  (53)..(53)
<223>  Xaa is any amino acid or a peptide bond, but not F

<220>
<221>  Xaa
<222>  (63)..(63)
<223>  Xaa is any amino acid or a peptide bond, but not D

<220>
<221>  Xaa
<222>  (73)..(73)
<223>  Xaa is any amino acid or a peptide bond, but not K

<220>
<221>  Xaa
<222>  (77)..(77)
<223>  Xaa is any amino acid or a peptide bond, but not A

<220>
<221>  Xaa
<222>  (79)..(79)
<223>  Xaa is any amino acid or a peptide bond, but not I

<220>
<221>  Xaa
<222>  (84)..(84)
<223>  Xaa is any amino acid or a peptide bond, but not R

<220>
<221>  Xaa
<222>  (85)..(85)
<223>  Xaa is any amino acid or a peptide bond, but not K

<220>
<221>  Xaa
<222>  (92)..(92)
<223>  Xaa is any amino acid or a peptide bond, but not R

<220>
<221>  Xaa
<222>  (96)..(96)
<223>  Xaa is any amino acid or a peptide bond, but not I

<220>
<221>  Xaa
<222>  (101)..(101)
<223>  Xaa is any amino acid or a peptide bond, but not Y

<220>
<221>  Xaa
<222>  (109)..(109)
<223>  Xaa is any amino acid or a peptide bond, but not R

<220>
<221>  Xaa
<222>  (127)..(127)
<223>  Xaa is any amino acid or a peptide bond, but not E

<220>
<221>  Xaa
<222>  (130)..(130)
<223>  Xaa is any amino acid or a peptide bond, but not T

<220>
<221>  Xaa
<222>  (131)..(131)
<223>  Xaa is any amino acid or a peptide bond, but not M

<220>
<221>  Xaa
<222>  (132)..(132)
<223>  Xaa is any amino acid or a peptide bond, but not T

<220>
<221>  Xaa
<222>  (133)..(133)
<223>  Xaa is any amino acid or a peptide bond, but not I

<220>
<221>  Xaa
<222>  (136)..(136)
<223>  Xaa is any amino acid or a peptide bond, but not I

<220>
<221>  Xaa
<222>  (140)..(140)
<223>  Xaa is any amino acid or a peptide bond, but not Y

<220>
<221>  Xaa
<222>  (145)..(145)
<223>  Xaa is any amino acid or a peptide bond, but not I

<220>
<221>  Xaa
<222>  (147)..(147)
<223>  Xaa is any amino acid or a peptide bond, but not S

<220>
<221>  Xaa
<222>  (152)..(152)
<223>  Xaa is any amino acid or a peptide bond, but not F

<220>
<221>  Xaa
<222>  (153)..(153)
<223>  Xaa is any amino acid or a peptide bond, but not F

<220>
<221>  Xaa
<222>  (159)..(159)
<223>  Xaa is any amino acid or a peptide bond, but not A

<220>
<221>  Xaa
<222>  (160)..(160)
<223>  Xaa is any amino acid or a peptide bond, but not D

<220>
<221>  Xaa
<222>  (161)..(161)
<223>  Xaa is any amino acid or a peptide bond, but not A

<220>
<221>  Xaa
<222>  (163)..(163)
<223>  Xaa is any amino acid or a peptide bond, but not T

<220>
<221>  Xaa
<222>  (164)..(164)
<223>  Xaa is any amino acid or a peptide bond, but not V

<220>
<221>  Xaa
<222>  (169)..(169)
<223>  Xaa is any amino acid or a peptide bond, but not M

<400>  37

Glu Xaa Gly Leu Trp Glu Asn Ile Val Tyr Leu Asp Phe Arg Xaa Leu 
1               5                   10                  15      


Tyr Pro Ser Ile Ile Ile Thr His Asn Val Ser Pro Asp Thr Leu Asn 
            20                  25                  30          


Xaa Glu Gly Cys Lys Xaa Tyr Asp Xaa Ala Pro Gln Val Gly His Xaa 
        35                  40                  45              


Phe Cys Lys Asp Xaa Pro Gly Phe Ile Pro Ser Leu Leu Gly Xaa Leu 
    50                  55                  60                  


Leu Glu Glu Arg Gln Lys Ile Lys Xaa Lys Met Lys Xaa Thr Xaa Asp 
65                  70                  75                  80  


Pro Ile Glu Xaa Xaa Leu Leu Asp Tyr Arg Gln Xaa Ala Ile Lys Xaa 
                85                  90                  95      


Leu Ala Asn Ser Xaa Tyr Gly Tyr Tyr Gly Tyr Ala Xaa Ala Arg Trp 
            100                 105                 110         


Tyr Cys Lys Glu Cys Ala Glu Ser Val Thr Ala Trp Gly Arg Xaa Tyr 
        115                 120                 125             


Ile Xaa Xaa Xaa Xaa Lys Glu Xaa Glu Glu Lys Xaa Gly Phe Lys Val 
    130                 135                 140                 


Xaa Tyr Xaa Asp Thr Asp Gly Xaa Xaa Ala Thr Ile Pro Gly Xaa Xaa 
145                 150                 155                 160 


Xaa Glu Xaa Xaa Lys Lys Lys Ala Xaa Glu 
                165                 170 


<210>  38
<211>  777
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus Sequence


<220>
<221>  Xaa
<222>  (1)..(4)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (6)..(10)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (12)..(17)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (19)..(24)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (26)..(29)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (31)..(34)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (36)..(37)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (39)..(42)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (44)..(46)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (48)..(55)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (57)..(60)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (63)..(63)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (68)..(71)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (73)..(77)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (79)..(79)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (82)..(86)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (89)..(94)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (96)..(97)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (99)..(99)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (101)..(106)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (108)..(109)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (111)..(126)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (128)..(131)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (133)..(136)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (138)..(152)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (155)..(157)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (159)..(165)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (168)..(168)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (170)..(175)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (177)..(181)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (183)..(185)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (187)..(196)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (200)..(204)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (208)..(212)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (214)..(216)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (218)..(219)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (221)..(222)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (224)..(228)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (233)..(242)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (244)..(245)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (247)..(248)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (251)..(263)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (265)..(266)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (268)..(283)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (285)..(286)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (288)..(294)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (296)..(297)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (300)..(302)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (304)..(311)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (313)..(319)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (321)..(332)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (334)..(338)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (340)..(341)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (343)..(368)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (370)..(374)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (376)..(376)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (378)..(378)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (381)..(384)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (386)..(387)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (389)..(390)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (392)..(396)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (398)..(409)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (411)..(427)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (429)..(432)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (434)..(435)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (437)..(442)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (444)..(447)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (449)..(457)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (459)..(467)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (469)..(471)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (473)..(473)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (475)..(478)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (481)..(486)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (488)..(490)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (492)..(495)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (497)..(503)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (505)..(521)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (523)..(524)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (529)..(530)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (532)..(534)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (536)..(539)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (541)..(541)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (543)..(546)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (549)..(553)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (557)..(557)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (560)..(563)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (565)..(566)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (568)..(571)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (573)..(576)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (578)..(595)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (597)..(605)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (608)..(631)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (634)..(635)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (637)..(640)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (642)..(649)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (652)..(653)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (656)..(657)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (659)..(663)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (665)..(665)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (667)..(671)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (673)..(673)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (676)..(678)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (680)..(687)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (689)..(691)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (693)..(696)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (698)..(699)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (701)..(702)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (704)..(707)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (709)..(709)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (711)..(711)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (713)..(713)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (716)..(718)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (722)..(722)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (724)..(725)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (727)..(744)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (746)..(748)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (751)..(768)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (771)..(772)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (775)..(775)
<223>  Xaa is any amino acid or a peptide bond

<400>  38

Xaa Xaa Xaa Xaa Thr Xaa Xaa Xaa Xaa Xaa Asp Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Ile Xaa Xaa Xaa Xaa Xaa Xaa Glu Xaa Xaa Xaa Xaa Tyr Xaa Xaa 
            20                  25                  30          


Xaa Xaa Glu Xaa Xaa Phe Xaa Xaa Xaa Xaa Lys Xaa Xaa Xaa Ala Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Xaa Xaa Xaa Xaa Thr Val Xaa Thr 
    50                  55                  60                  


Val Lys Arg Xaa Xaa Xaa Xaa Gln Xaa Xaa Xaa Xaa Xaa Arg Xaa Val 
65                  70                  75                  80  


Glu Xaa Xaa Xaa Xaa Xaa Phe Thr Xaa Xaa Xaa Xaa Xaa Xaa Ala Xaa 
                85                  90                  95      


Xaa Asp Xaa Ile Xaa Xaa Xaa Xaa Xaa Xaa Ile Xaa Xaa Tyr Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Val Xaa 
        115                 120                 125             


Xaa Xaa Xaa Asp Xaa Xaa Xaa Xaa Met Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Glu Xaa Xaa Xaa Leu Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Glu Gly Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Val 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Asp Xaa Xaa Xaa Thr Xaa Xaa Xaa Xaa Xaa Xaa 
            180                 185                 190         


Xaa Xaa Xaa Xaa Val Val Lys Xaa Xaa Xaa Xaa Xaa Val Leu Ile Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Asn Xaa Xaa Xaa Ala Xaa Xaa Lys Xaa Xaa Cys Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Asn Phe Ala Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Ile Xaa Xaa Met Xaa Xaa Arg Phe Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Pro Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Val Xaa Xaa Gln Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Glu Xaa Xaa Thr Thr Xaa Xaa Xaa Thr Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Val 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Val Xaa Xaa Pro Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Val Xaa Xaa Xaa Xaa Xaa Ser Xaa Glu Xaa Tyr Gln Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Glu Xaa Xaa Thr Xaa Xaa Phe Xaa Xaa Xaa Xaa Xaa Lys Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Xaa Xaa Xaa Xaa Xaa Xaa 
                405                 410                 415     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa 
            420                 425                 430         


Asn Xaa Xaa Ile Xaa Xaa Xaa Xaa Xaa Xaa Lys Xaa Xaa Xaa Xaa Ile 
        435                 440                 445             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Xaa Xaa Xaa Xaa Xaa Xaa 
    450                 455                 460                 


Xaa Xaa Xaa Thr Xaa Xaa Xaa Glu Xaa Gln Xaa Xaa Xaa Xaa Lys Ile 
465                 470                 475                 480 


Xaa Xaa Xaa Xaa Xaa Xaa Lys Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa Phe 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Xaa Xaa Glu Leu Val Trp 
        515                 520                 525             


Xaa Xaa Leu Xaa Xaa Xaa Phe Xaa Xaa Xaa Xaa Leu Xaa Ile Xaa Xaa 
    530                 535                 540                 


Xaa Xaa Leu Tyr Xaa Xaa Xaa Xaa Xaa Gly Glu Ser Xaa Glu Ile Xaa 
545                 550                 555                 560 


Xaa Xaa Xaa Leu Xaa Xaa Leu Xaa Xaa Xaa Xaa Ala Xaa Xaa Xaa Xaa 
                565                 570                 575     


Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            580                 585                 590         


Xaa Xaa Xaa Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Thr Xaa 
        595                 600                 605             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    610                 615                 620                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Leu Xaa Xaa Asp Xaa Xaa Xaa Xaa 
625                 630                 635                 640 


Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Thr Glu Xaa Xaa Ser Lys Xaa 
                645                 650                 655     


Xaa Val Xaa Xaa Xaa Xaa Xaa Val Xaa His Xaa Xaa Xaa Xaa Xaa Asp 
            660                 665                 670         


Xaa Lys Asp Xaa Xaa Xaa Thr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Arg 
        675                 680                 685             


Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa Arg Xaa Xaa Thr Xaa Xaa Ser Xaa 
    690                 695                 700                 


Xaa Xaa Xaa Lys Xaa Ser Xaa Arg Xaa Gly Asp Xaa Xaa Xaa Pro Phe 
705                 710                 715                 720 


Asp Xaa Phe Xaa Xaa Thr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                725                 730                 735     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu Xaa Xaa Xaa Arg Ala Xaa Xaa 
            740                 745                 750         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        755                 760                 765             


Ser Ala Xaa Xaa Lys Pro Xaa Gly Thr 
    770                 775         


<210>  39
<211>  777
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus Sequence


<220>
<221>  Xaa
<222>  (1)..(1)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (3)..(3)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (8)..(8)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (10)..(10)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (13)..(13)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (15)..(16)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (20)..(20)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (22)..(23)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (27)..(29)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (32)..(33)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (49)..(55)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (57)..(57)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (63)..(63)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (68)..(71)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (73)..(73)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (77)..(77)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (79)..(79)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (84)..(84)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (86)..(86)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (96)..(97)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (99)..(99)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (101)..(102)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (104)..(105)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (124)..(124)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (134)..(134)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (136)..(136)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (138)..(140)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (145)..(145)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (150)..(150)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (156)..(157)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (165)..(165)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (175)..(175)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (188)..(188)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (194)..(196)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (208)..(208)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (210)..(210)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (216)..(216)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (221)..(221)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (225)..(225)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (228)..(228)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (233)..(233)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (235)..(239)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (244)..(245)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (248)..(248)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (254)..(254)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (258)..(258)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (263)..(263)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (265)..(266)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (268)..(268)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (270)..(270)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (276)..(276)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (278)..(279)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (283)..(283)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (285)..(285)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (288)..(288)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (290)..(290)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (292)..(294)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (300)..(300)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (304)..(310)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (319)..(319)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (322)..(322)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (326)..(326)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (329)..(329)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (334)..(334)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (336)..(337)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (341)..(341)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (343)..(343)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (347)..(347)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (358)..(358)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (361)..(362)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (365)..(365)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (376)..(376)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (381)..(381)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (383)..(384)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (386)..(386)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (390)..(390)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (393)..(393)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (401)..(405)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (408)..(409)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (417)..(418)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (427)..(427)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (430)..(430)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (432)..(432)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (439)..(439)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (442)..(442)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (455)..(455)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (457)..(457)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (460)..(462)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (465)..(466)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (469)..(469)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (471)..(471)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (473)..(473)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (477)..(477)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (481)..(481)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (489)..(489)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (493)..(493)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (500)..(500)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (503)..(503)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (509)..(510)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (518)..(518)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (529)..(529)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (533)..(534)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (539)..(539)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (557)..(557)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (561)..(563)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (565)..(565)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (568)..(568)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (573)..(573)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (584)..(584)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (587)..(587)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (593)..(593)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (599)..(599)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (604)..(605)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (613)..(613)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (620)..(621)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (626)..(626)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (628)..(628)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (635)..(635)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (637)..(638)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (640)..(640)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (644)..(645)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (647)..(649)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (652)..(653)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (657)..(657)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (660)..(660)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (673)..(673)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (677)..(677)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (685)..(685)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (690)..(691)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (694)..(696)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (701)..(701)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (705)..(706)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (713)..(713)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (717)..(717)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (724)..(725)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (729)..(729)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (732)..(733)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (747)..(747)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (754)..(757)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (759)..(760)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (762)..(764)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (766)..(766)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (772)..(772)
<223>  Xaa is any amino acid or a peptide bond

<220>
<221>  Xaa
<222>  (775)..(775)
<223>  Xaa is any amino acid or a peptide bond

<400>  39

Xaa Ile Xaa Asp Thr Asp Tyr Xaa Thr Xaa Asp Gly Xaa Pro Xaa Xaa 
1               5                   10                  15      


Arg Ile Phe Xaa Lys Xaa Xaa Gly Glu Phe Xaa Xaa Xaa Tyr Asp Xaa 
            20                  25                  30          


Xaa Phe Glu Pro Tyr Phe Tyr Ala Leu Leu Lys Asp Asp Ser Ala Ile 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Xaa Arg His Gly Thr Val Xaa Thr 
    50                  55                  60                  


Val Lys Arg Xaa Xaa Xaa Xaa Gln Xaa Lys Phe Leu Xaa Arg Xaa Val 
65                  70                  75                  80  


Glu Val Trp Xaa Leu Xaa Phe Thr His Pro Gln Asp Val Pro Ala Xaa 
                85                  90                  95      


Xaa Asp Xaa Ile Xaa Xaa His Xaa Xaa Val Ile Asp Ile Tyr Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Xaa Gly Leu Val Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Xaa Leu Xaa Met Xaa Xaa Xaa Asp Ile Glu Thr 
    130                 135                 140                 


Xaa Tyr His Glu Gly Xaa Glu Phe Ala Glu Gly Xaa Xaa Leu Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Xaa Glu Gly Ala Arg Val Ile Thr Trp Lys Xaa Val 
                165                 170                 175     


Asp Leu Pro Tyr Val Asp Val Val Ser Thr Glu Xaa Glu Met Ile Lys 
            180                 185                 190         


Arg Xaa Xaa Xaa Val Val Lys Glu Lys Asp Pro Asp Val Leu Ile Xaa 
        195                 200                 205             


Tyr Xaa Gly Asp Asn Phe Asp Xaa Ala Tyr Leu Lys Xaa Arg Cys Glu 
    210                 215                 220                 


Xaa Leu Gly Xaa Asn Phe Ala Leu Xaa Arg Xaa Xaa Xaa Xaa Xaa Glu 
225                 230                 235                 240 


Pro Lys Ile Xaa Xaa Met Gly Xaa Arg Phe Ala Val Glu Xaa Lys Gly 
                245                 250                 255     


Arg Xaa His Phe Asp Leu Xaa Pro Xaa Xaa Arg Xaa Thr Xaa Asn Leu 
            260                 265                 270         


Pro Thr Tyr Xaa Leu Xaa Xaa Val Tyr Glu Xaa Val Xaa Gly Gln Xaa 
        275                 280                 285             


Lys Xaa Lys Xaa Xaa Xaa Glu Glu Ile Thr Thr Xaa Trp Glu Thr Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Ala Arg Tyr Ser Met Glu Asp Ala Xaa Val 
305                 310                 315                 320 


Thr Xaa Glu Leu Gly Xaa Glu Phe Xaa Pro Met Glu Ala Xaa Leu Xaa 
                325                 330                 335     


Xaa Leu Val Gly Xaa Pro Xaa Trp Asp Val Xaa Arg Ser Ser Thr Gly 
            340                 345                 350         


Asn Leu Val Glu Trp Xaa Leu Leu Xaa Xaa Ala Tyr Xaa Arg Asn Glu 
        355                 360                 365             


Val Ala Pro Asn Lys Pro Ser Xaa Glu Glu Tyr Gln Xaa Arg Xaa Xaa 
    370                 375                 380                 


Glu Xaa Tyr Thr Gly Xaa Phe Val Xaa Glu Pro Glu Lys Gly Leu Trp 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Leu Asp Xaa Xaa Ala Leu Tyr Pro Ser Ile Ile 
                405                 410                 415     


Xaa Xaa His Asn Val Ser Pro Asp Thr Leu Xaa Leu Glu Xaa Cys Xaa 
            420                 425                 430         


Asn Tyr Asp Ile Ala Pro Xaa Val Gly Xaa Lys Phe Cys Lys Asp Ile 
        435                 440                 445             


Pro Gly Phe Ile Pro Ser Xaa Leu Xaa His Leu Xaa Xaa Xaa Arg Gln 
    450                 455                 460                 


Xaa Xaa Lys Thr Xaa Met Xaa Glu Xaa Gln Asp Pro Xaa Glu Lys Ile 
465                 470                 475                 480 


Xaa Leu Asp Tyr Arg Gln Lys Ala Xaa Lys Leu Leu Xaa Asn Ser Phe 
                485                 490                 495     


Tyr Gly Tyr Xaa Gly Tyr Xaa Lys Ala Arg Trp Tyr Xaa Xaa Glu Cys 
            500                 505                 510         


Ala Glu Ser Val Thr Xaa Trp Gly Arg Lys Tyr Ile Glu Leu Val Trp 
        515                 520                 525             


Xaa Glu Leu Glu Xaa Xaa Phe Gly Phe Lys Xaa Leu Tyr Ile Asp Thr 
    530                 535                 540                 


Asp Gly Leu Tyr Ala Thr Ile Pro Gly Gly Glu Ser Xaa Glu Ile Lys 
545                 550                 555                 560 


Xaa Xaa Xaa Leu Xaa Phe Leu Xaa Tyr Ile Asn Ala Xaa Leu Pro Gly 
                565                 570                 575     


Ala Leu Glu Leu Glu Tyr Glu Xaa Phe Tyr Xaa Arg Gly Phe Phe Val 
            580                 585                 590         


Xaa Lys Lys Lys Tyr Ala Xaa Ile Asp Glu Glu Xaa Xaa Ile Thr Thr 
        595                 600                 605             


Arg Gly Leu Glu Xaa Val Arg Arg Asp Trp Ser Xaa Xaa Ala Lys Glu 
    610                 615                 620                 


Thr Xaa Ala Xaa Val Leu Glu Ala Leu Leu Xaa Asp Xaa Xaa Val Xaa 
625                 630                 635                 640 


Lys Ala Val Xaa Xaa Val Xaa Xaa Xaa Thr Glu Xaa Xaa Ser Lys Tyr 
                645                 650                 655     


Xaa Val Pro Xaa Glu Lys Leu Val Ile His Glu Gln Ile Thr Arg Asp 
            660                 665                 670         


Xaa Lys Asp Tyr Xaa Ala Thr Gly Pro His Val Ala Xaa Ala Lys Arg 
        675                 680                 685             


Leu Xaa Xaa Arg Gly Xaa Xaa Xaa Arg Pro Gly Thr Xaa Ile Ser Tyr 
    690                 695                 700                 


Xaa Xaa Leu Lys Gly Ser Gly Arg Xaa Gly Asp Arg Xaa Ile Pro Phe 
705                 710                 715                 720 


Asp Glu Phe Xaa Xaa Thr Lys His Xaa Tyr Asp Xaa Xaa Tyr Tyr Ile 
                725                 730                 735     


Glu Asn Gln Val Leu Pro Ala Val Glu Arg Xaa Leu Arg Ala Phe Gly 
            740                 745                 750         


Tyr Xaa Xaa Xaa Xaa Leu Xaa Xaa Gln Xaa Xaa Xaa Gln Xaa Gly Leu 
        755                 760                 765             


Ser Ala Trp Xaa Lys Pro Xaa Gly Thr 
    770                 775         


<210>  40
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  40
tttggaaaca tctggagtcc t                                                 21


<210>  41
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  41
gcccaaaggg aactgatagt c                                                 21


<210>  42
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  42
gttttcccag tcacgac                                                      17


<210>  43
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  43
ggtatcttta tagtcctgtc g                                                 21


<210>  44
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  44
gttttcccag tcacgacgtt gtaaaacgac ggcc                                   34


<210>  45
<211>  775
<212>  PRT
<213>  Pyrococcus sp. GB-D

<400>  45

Met Ile Leu Asp Ala Asp Tyr Ile Thr Glu Asp Gly Lys Pro Ile Ile 
1               5                   10                  15      


Arg Ile Phe Lys Lys Glu Asn Gly Glu Phe Lys Val Glu Tyr Asp Arg 
            20                  25                  30          


Asn Phe Arg Pro Tyr Ile Tyr Ala Leu Leu Lys Asp Asp Ser Gln Ile 
        35                  40                  45              


Asp Glu Val Arg Lys Ile Thr Ala Glu Arg His Gly Lys Ile Val Arg 
    50                  55                  60                  


Ile Ile Asp Ala Glu Lys Val Arg Lys Lys Phe Leu Gly Arg Pro Ile 
65                  70                  75                  80  


Glu Val Trp Arg Leu Tyr Phe Glu His Pro Gln Asp Val Pro Ala Ile 
                85                  90                  95      


Arg Asp Lys Ile Arg Glu His Ser Ala Val Ile Asp Ile Phe Glu Tyr 
            100                 105                 110         


Asp Ile Pro Phe Ala Lys Arg Tyr Leu Ile Asp Lys Gly Leu Ile Pro 
        115                 120                 125             


Met Glu Gly Asp Glu Glu Leu Lys Leu Leu Ala Phe Asp Ile Glu Thr 
    130                 135                 140                 


Leu Tyr His Glu Gly Glu Glu Phe Ala Lys Gly Pro Ile Ile Met Ile 
145                 150                 155                 160 


Ser Tyr Ala Asp Glu Glu Glu Ala Lys Val Ile Thr Trp Lys Lys Ile 
                165                 170                 175     


Asp Leu Pro Tyr Val Glu Val Val Ser Ser Glu Arg Glu Met Ile Lys 
            180                 185                 190         


Arg Phe Leu Lys Val Ile Arg Glu Lys Asp Pro Asp Val Ile Ile Thr 
        195                 200                 205             


Tyr Asn Gly Asp Ser Phe Asp Leu Pro Tyr Leu Val Lys Arg Ala Glu 
    210                 215                 220                 


Lys Leu Gly Ile Lys Leu Pro Leu Gly Arg Asp Gly Ser Glu Pro Lys 
225                 230                 235                 240 


Met Gln Arg Leu Gly Asp Met Thr Ala Val Glu Ile Lys Gly Arg Ile 
                245                 250                 255     


His Phe Asp Leu Tyr His Val Ile Arg Arg Thr Ile Asn Leu Pro Thr 
            260                 265                 270         


Tyr Thr Leu Glu Ala Val Tyr Glu Ala Ile Phe Gly Lys Pro Lys Glu 
        275                 280                 285             


Lys Val Tyr Ala His Glu Ile Ala Glu Ala Trp Glu Thr Gly Lys Gly 
    290                 295                 300                 


Leu Glu Arg Val Ala Lys Tyr Ser Met Glu Asp Ala Lys Val Thr Tyr 
305                 310                 315                 320 


Glu Leu Gly Arg Glu Phe Phe Pro Met Glu Ala Gln Leu Ser Arg Leu 
                325                 330                 335     


Val Gly Gln Pro Leu Trp Asp Val Ser Arg Ser Ser Thr Gly Asn Leu 
            340                 345                 350         


Val Glu Trp Tyr Leu Leu Arg Lys Ala Tyr Glu Arg Asn Glu Leu Ala 
        355                 360                 365             


Pro Asn Lys Pro Asp Glu Arg Glu Tyr Glu Arg Arg Leu Arg Glu Ser 
    370                 375                 380                 


Tyr Ala Gly Gly Tyr Val Lys Glu Pro Glu Lys Gly Leu Trp Glu Gly 
385                 390                 395                 400 


Leu Val Ser Leu Asp Phe Arg Ser Leu Tyr Pro Ser Ile Ile Ile Thr 
                405                 410                 415     


His Asn Val Ser Pro Asp Thr Leu Asn Arg Glu Gly Cys Arg Glu Tyr 
            420                 425                 430         


Asp Val Ala Pro Glu Val Gly His Lys Phe Cys Lys Asp Phe Pro Gly 
        435                 440                 445             


Phe Ile Pro Ser Leu Leu Lys Arg Leu Leu Asp Glu Arg Gln Glu Ile 
    450                 455                 460                 


Lys Arg Lys Met Lys Ala Ser Lys Asp Pro Ile Glu Lys Lys Met Leu 
465                 470                 475                 480 


Asp Tyr Arg Gln Arg Ala Ile Lys Ile Leu Ala Asn Ser Tyr Tyr Gly 
                485                 490                 495     


Tyr Tyr Gly Tyr Ala Lys Ala Arg Trp Tyr Cys Lys Glu Cys Ala Glu 
            500                 505                 510         


Ser Val Thr Ala Trp Gly Arg Glu Tyr Ile Glu Phe Val Arg Lys Glu 
        515                 520                 525             


Leu Glu Glu Lys Phe Gly Phe Lys Val Leu Tyr Ile Asp Thr Asp Gly 
    530                 535                 540                 


Leu Tyr Ala Thr Ile Pro Gly Ala Lys Pro Glu Glu Ile Lys Lys Lys 
545                 550                 555                 560 


Ala Leu Glu Phe Val Asp Tyr Ile Asn Ala Lys Leu Pro Gly Leu Leu 
                565                 570                 575     


Glu Leu Glu Tyr Glu Gly Phe Tyr Val Arg Gly Phe Phe Val Thr Lys 
            580                 585                 590         


Lys Lys Tyr Ala Leu Ile Asp Glu Glu Gly Lys Ile Ile Thr Arg Gly 
        595                 600                 605             


Leu Glu Ile Val Arg Arg Asp Trp Ser Glu Ile Ala Lys Glu Thr Gln 
    610                 615                 620                 


Ala Lys Val Leu Glu Ala Ile Leu Lys His Gly Asn Val Glu Glu Ala 
625                 630                 635                 640 


Val Lys Ile Val Lys Glu Val Thr Glu Lys Leu Ser Lys Tyr Glu Ile 
                645                 650                 655     


Pro Pro Glu Lys Leu Val Ile Tyr Glu Gln Ile Thr Arg Pro Leu His 
            660                 665                 670         


Glu Tyr Lys Ala Ile Gly Pro His Val Ala Val Ala Lys Arg Leu Ala 
        675                 680                 685             


Ala Arg Gly Val Lys Val Arg Pro Gly Met Val Ile Gly Tyr Ile Val 
    690                 695                 700                 


Leu Arg Gly Asp Gly Pro Ile Ser Lys Arg Ala Ile Leu Ala Glu Glu 
705                 710                 715                 720 


Phe Asp Leu Arg Lys His Lys Tyr Asp Ala Glu Tyr Tyr Ile Glu Asn 
                725                 730                 735     


Gln Val Leu Pro Ala Val Leu Arg Ile Leu Glu Ala Phe Gly Tyr Arg 
            740                 745                 750         


Lys Glu Asp Leu Arg Trp Gln Lys Thr Lys Gln Thr Gly Leu Thr Ala 
        755                 760                 765             


Trp Leu Asn Ile Lys Lys Lys 
    770                 775 


