                         SEQUENCE LISTING

<110>  Schering Corporation
       Beaumont, Maribel
       Cayatte, Corinne
 
<120>  INFLAMMATORY BOWEL DISEASE BIOMARKERS

<130>  BP06867WO

<150>  US 61/110,756
<151>  2008-11-03

<150>  US 61/225,847
<151>  2009-07-15

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  189
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(19)

<400>  1

Met Leu Gly Ser Arg Ala Val Met Leu Leu Leu Leu Leu Pro Trp Thr 
1               5                   10                  15      


Ala Gln Gly Arg Ala Val Pro Gly Gly Ser Ser Pro Ala Trp Thr Gln 
            20                  25                  30          


Cys Gln Gln Leu Ser Gln Lys Leu Cys Thr Leu Ala Trp Ser Ala His 
        35                  40                  45              


Pro Leu Val Gly His Met Asp Leu Arg Glu Glu Gly Asp Glu Glu Thr 
    50                  55                  60                  


Thr Asn Asp Val Pro His Ile Gln Cys Gly Asp Gly Cys Asp Pro Gln 
65                  70                  75                  80  


Gly Leu Arg Asp Asn Ser Gln Phe Cys Leu Gln Arg Ile His Gln Gly 
                85                  90                  95      


Leu Ile Phe Tyr Glu Lys Leu Leu Gly Ser Asp Ile Phe Thr Gly Glu 
            100                 105                 110         


Pro Ser Leu Leu Pro Asp Ser Pro Val Gly Gln Leu His Ala Ser Leu 
        115                 120                 125             


Leu Gly Leu Ser Gln Leu Leu Gln Pro Glu Gly His His Trp Glu Thr 
    130                 135                 140                 


Gln Gln Ile Pro Ser Leu Ser Pro Ser Gln Pro Trp Gln Arg Leu Leu 
145                 150                 155                 160 


Leu Arg Phe Lys Ile Leu Arg Ser Leu Gln Ala Phe Val Ala Val Ala 
                165                 170                 175     


Ala Arg Val Phe Ala His Gly Ala Ala Thr Leu Ser Pro 
            180                 185                 


<210>  2
<211>  328
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(22)

<400>  2

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser 
                325             


<210>  3
<211>  629
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(23)

<400>  3

Met Asn Gln Val Thr Ile Gln Trp Asp Ala Val Ile Ala Leu Tyr Ile 
1               5                   10                  15      


Leu Phe Ser Trp Cys His Gly Gly Ile Thr Asn Ile Asn Cys Ser Gly 
            20                  25                  30          


His Ile Trp Val Glu Pro Ala Thr Ile Phe Lys Met Gly Met Asn Ile 
        35                  40                  45              


Ser Ile Tyr Cys Gln Ala Ala Ile Lys Asn Cys Gln Pro Arg Lys Leu 
    50                  55                  60                  


His Phe Tyr Lys Asn Gly Ile Lys Glu Arg Phe Gln Ile Thr Arg Ile 
65                  70                  75                  80  


Asn Lys Thr Thr Ala Arg Leu Trp Tyr Lys Asn Phe Leu Glu Pro His 
                85                  90                  95      


Ala Ser Met Tyr Cys Thr Ala Glu Cys Pro Lys His Phe Gln Glu Thr 
            100                 105                 110         


Leu Ile Cys Gly Lys Asp Ile Ser Ser Gly Tyr Pro Pro Asp Ile Pro 
        115                 120                 125             


Asp Glu Val Thr Cys Val Ile Tyr Glu Tyr Ser Gly Asn Met Thr Cys 
    130                 135                 140                 


Thr Trp Asn Ala Gly Lys Leu Thr Tyr Ile Asp Thr Lys Tyr Val Val 
145                 150                 155                 160 


His Val Lys Ser Leu Glu Thr Glu Glu Glu Gln Gln Tyr Leu Thr Ser 
                165                 170                 175     


Ser Tyr Ile Asn Ile Ser Thr Asp Ser Leu Gln Gly Gly Lys Lys Tyr 
            180                 185                 190         


Leu Val Trp Val Gln Ala Ala Asn Ala Leu Gly Met Glu Glu Ser Lys 
        195                 200                 205             


Gln Leu Gln Ile His Leu Asp Asp Ile Val Ile Pro Ser Ala Ala Val 
    210                 215                 220                 


Ile Ser Arg Ala Glu Thr Ile Asn Ala Thr Val Pro Lys Thr Ile Ile 
225                 230                 235                 240 


Tyr Trp Asp Ser Gln Thr Thr Ile Glu Lys Val Ser Cys Glu Met Arg 
                245                 250                 255     


Tyr Lys Ala Thr Thr Asn Gln Thr Trp Asn Val Lys Glu Phe Asp Thr 
            260                 265                 270         


Asn Phe Thr Tyr Val Gln Gln Ser Glu Phe Tyr Leu Glu Pro Asn Ile 
        275                 280                 285             


Lys Tyr Val Phe Gln Val Arg Cys Gln Glu Thr Gly Lys Arg Tyr Trp 
    290                 295                 300                 


Gln Pro Trp Ser Ser Leu Phe Phe His Lys Thr Pro Glu Thr Val Pro 
305                 310                 315                 320 


Gln Val Thr Ser Lys Ala Phe Gln His Asp Thr Trp Asn Ser Gly Leu 
                325                 330                 335     


Thr Val Ala Ser Ile Ser Thr Gly His Leu Thr Ser Asp Asn Arg Gly 
            340                 345                 350         


Asp Ile Gly Leu Leu Leu Gly Met Ile Val Phe Ala Val Met Leu Ser 
        355                 360                 365             


Ile Leu Ser Leu Ile Gly Ile Phe Asn Arg Ser Phe Arg Thr Gly Ile 
    370                 375                 380                 


Lys Arg Arg Ile Leu Leu Leu Ile Pro Lys Trp Leu Tyr Glu Asp Ile 
385                 390                 395                 400 


Pro Asn Met Lys Asn Ser Asn Val Val Lys Met Leu Gln Glu Asn Ser 
                405                 410                 415     


Glu Leu Met Asn Asn Asn Ser Ser Glu Gln Val Leu Tyr Val Asp Pro 
            420                 425                 430         


Met Ile Thr Glu Ile Lys Glu Ile Phe Ile Pro Glu His Lys Pro Thr 
        435                 440                 445             


Asp Tyr Lys Lys Glu Asn Thr Gly Pro Leu Glu Thr Arg Asp Tyr Pro 
    450                 455                 460                 


Gln Asn Ser Leu Phe Asp Asn Thr Thr Val Val Tyr Ile Pro Asp Leu 
465                 470                 475                 480 


Asn Thr Gly Tyr Lys Pro Gln Ile Ser Asn Phe Leu Pro Glu Gly Ser 
                485                 490                 495     


His Leu Ser Asn Asn Asn Glu Ile Thr Ser Leu Thr Leu Lys Pro Pro 
            500                 505                 510         


Val Asp Ser Leu Asp Ser Gly Asn Asn Pro Arg Leu Gln Lys His Pro 
        515                 520                 525             


Asn Phe Ala Phe Ser Val Ser Ser Val Asn Ser Leu Ser Asn Thr Ile 
    530                 535                 540                 


Phe Leu Gly Glu Leu Ser Leu Ile Leu Asn Gln Gly Glu Cys Ser Ser 
545                 550                 555                 560 


Pro Asp Ile Gln Asn Ser Val Glu Glu Glu Thr Thr Met Leu Leu Glu 
                565                 570                 575     


Asn Asp Ser Pro Ser Glu Thr Ile Pro Glu Gln Thr Leu Leu Pro Asp 
            580                 585                 590         


Glu Phe Val Ser Cys Leu Gly Ile Val Asn Glu Glu Leu Pro Ser Ile 
        595                 600                 605             


Asn Thr Tyr Phe Pro Gln Asn Ile Leu Glu Ser His Phe Asn Arg Ile 
    610                 615                 620                 


Ser Leu Leu Glu Lys 
625                 


<210>  4
<211>  662
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(24)

<400>  4

Met Glu Pro Leu Val Thr Trp Val Val Pro Leu Leu Phe Leu Phe Leu 
1               5                   10                  15      


Leu Ser Arg Gln Gly Ala Ala Cys Arg Thr Ser Glu Cys Cys Phe Gln 
            20                  25                  30          


Asp Pro Pro Tyr Pro Asp Ala Asp Ser Gly Ser Ala Ser Gly Pro Arg 
        35                  40                  45              


Asp Leu Arg Cys Tyr Arg Ile Ser Ser Asp Arg Tyr Glu Cys Ser Trp 
    50                  55                  60                  


Gln Tyr Glu Gly Pro Thr Ala Gly Val Ser His Phe Leu Arg Cys Cys 
65                  70                  75                  80  


Leu Ser Ser Gly Arg Cys Cys Tyr Phe Ala Ala Gly Ser Ala Thr Arg 
                85                  90                  95      


Leu Gln Phe Ser Asp Gln Ala Gly Val Ser Val Leu Tyr Thr Val Thr 
            100                 105                 110         


Leu Trp Val Glu Ser Trp Ala Arg Asn Gln Thr Glu Lys Ser Pro Glu 
        115                 120                 125             


Val Thr Leu Gln Leu Tyr Asn Ser Val Lys Tyr Glu Pro Pro Leu Gly 
    130                 135                 140                 


Asp Ile Lys Val Ser Lys Leu Ala Gly Gln Leu Arg Met Glu Trp Glu 
145                 150                 155                 160 


Thr Pro Asp Asn Gln Val Gly Ala Glu Val Gln Phe Arg His Arg Thr 
                165                 170                 175     


Pro Ser Ser Pro Trp Lys Leu Gly Asp Cys Gly Pro Gln Asp Asp Asp 
            180                 185                 190         


Thr Glu Ser Cys Leu Cys Pro Leu Glu Met Asn Val Ala Gln Glu Phe 
        195                 200                 205             


Gln Leu Arg Arg Arg Gln Leu Gly Ser Gln Gly Ser Ser Trp Ser Lys 
    210                 215                 220                 


Trp Ser Ser Pro Val Cys Val Pro Pro Glu Asn Pro Pro Gln Pro Gln 
225                 230                 235                 240 


Val Arg Phe Ser Val Glu Gln Leu Gly Gln Asp Gly Arg Arg Arg Leu 
                245                 250                 255     


Thr Leu Lys Glu Gln Pro Thr Gln Leu Glu Leu Pro Glu Gly Cys Gln 
            260                 265                 270         


Gly Leu Ala Pro Gly Thr Glu Val Thr Tyr Arg Leu Gln Leu His Met 
        275                 280                 285             


Leu Ser Cys Pro Cys Lys Ala Lys Ala Thr Arg Thr Leu His Leu Gly 
    290                 295                 300                 


Lys Met Pro Tyr Leu Ser Gly Ala Ala Tyr Asn Val Ala Val Ile Ser 
305                 310                 315                 320 


Ser Asn Gln Phe Gly Pro Gly Leu Asn Gln Thr Trp His Ile Pro Ala 
                325                 330                 335     


Asp Thr His Thr Glu Pro Val Ala Leu Asn Ile Ser Val Gly Thr Asn 
            340                 345                 350         


Gly Thr Thr Met Tyr Trp Pro Ala Arg Ala Gln Ser Met Thr Tyr Cys 
        355                 360                 365             


Ile Glu Trp Gln Pro Val Gly Gln Asp Gly Gly Leu Ala Thr Cys Ser 
    370                 375                 380                 


Leu Thr Ala Pro Gln Asp Pro Asp Pro Ala Gly Met Ala Thr Tyr Ser 
385                 390                 395                 400 


Trp Ser Arg Glu Ser Gly Ala Met Gly Gln Glu Lys Cys Tyr Tyr Ile 
                405                 410                 415     


Thr Ile Phe Ala Ser Ala His Pro Glu Lys Leu Thr Leu Trp Ser Thr 
            420                 425                 430         


Val Leu Ser Thr Tyr His Phe Gly Gly Asn Ala Ser Ala Ala Gly Thr 
        435                 440                 445             


Pro His His Val Ser Val Lys Asn His Ser Leu Asp Ser Val Ser Val 
    450                 455                 460                 


Asp Trp Ala Pro Ser Leu Leu Ser Thr Cys Pro Gly Val Leu Lys Glu 
465                 470                 475                 480 


Tyr Val Val Arg Cys Arg Asp Glu Asp Ser Lys Gln Val Ser Glu His 
                485                 490                 495     


Pro Val Gln Pro Thr Glu Thr Gln Val Thr Leu Ser Gly Leu Arg Ala 
            500                 505                 510         


Gly Val Ala Tyr Thr Val Gln Val Arg Ala Asp Thr Ala Trp Leu Arg 
        515                 520                 525             


Gly Val Trp Ser Gln Pro Gln Arg Phe Ser Ile Glu Val Gln Val Ser 
    530                 535                 540                 


Asp Trp Leu Ile Phe Phe Ala Ser Leu Gly Ser Phe Leu Ser Ile Leu 
545                 550                 555                 560 


Leu Val Gly Val Leu Gly Tyr Leu Gly Leu Asn Arg Ala Ala Arg His 
                565                 570                 575     


Leu Cys Pro Pro Leu Pro Thr Pro Cys Ala Ser Ser Ala Ile Glu Phe 
            580                 585                 590         


Pro Gly Gly Lys Glu Thr Trp Gln Trp Ile Asn Pro Val Asp Phe Gln 
        595                 600                 605             


Glu Glu Ala Ser Leu Gln Glu Ala Leu Val Val Glu Met Ser Trp Asp 
    610                 615                 620                 


Lys Gly Glu Arg Thr Glu Pro Leu Glu Lys Thr Glu Leu Pro Glu Gly 
625                 630                 635                 640 


Ala Pro Glu Leu Ala Leu Asp Thr Glu Leu Ser Leu Glu Asp Gly Asp 
                645                 650                 655     


Arg Cys Lys Ala Lys Met 
            660         


<210>  5
<211>  851
<212>  DNA
<213>  Homo sapiens

<400>  5
agaatataac agcactccca aagaactggg tactcaacac tgagcagatc tgttctttga       60

gctaaaaacc atgtgctgta ccaagagttt gctcctggct gctttgatgt cagtgctgct      120

actccacctc tgcggcgaat cagaagcagc aagcaacttt gactgctgtc ttggatacac      180

agaccgtatt cttcatccta aatttattgt gggcttcaca cggcagctgg ccaatgaagg      240

ctgtgacatc aatgctatca tctttcacac aaagaaaaag ttgtctgtgt gcgcaaatcc      300

aaaacagact tgggtgaaat atattgtgcg tctcctcagt aaaaaagtca agaacatgta      360

aaaactgtgg cttttctgga atggaattgg acatagccca agaacagaaa gaaccttgct      420

ggggttggag gtttcacttg cacatcatgg agggtttagt gcttatctaa tttgtgcctc      480

actggacttg tccaattaat gaagttgatt catattgcat catagtttgc tttgtttaag      540

catcacatta aagttaaact gtattttatg ttatttatag ctgtaggttt tctgtgttta      600

gctatttaat actaattttc cataagctat tttggtttag tgcaaagtat aaaattatat      660

ttggggggga ataagattat atggactttc ttgcaagcaa caagctattt tttaaaaaaa      720

actatttaac attcttttgt ttatattgtt ttgtctccta aattgttgta attgcattat      780

aaaataagaa aaatattaat aagacaaata ttgaaaataa agaaacaaaa agttcttctg      840

ttaaaaaaaa a                                                           851


<210>  6
<211>  96
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(26)

<400>  6

Met Cys Cys Thr Lys Ser Leu Leu Leu Ala Ala Leu Met Ser Val Leu 
1               5                   10                  15      


Leu Leu His Leu Cys Gly Glu Ser Glu Ala Ala Ser Asn Phe Asp Cys 
            20                  25                  30          


Cys Leu Gly Tyr Thr Asp Arg Ile Leu His Pro Lys Phe Ile Val Gly 
        35                  40                  45              


Phe Thr Arg Gln Leu Ala Asn Glu Gly Cys Asp Ile Asn Ala Ile Ile 
    50                  55                  60                  


Phe His Thr Lys Lys Lys Leu Ser Val Cys Ala Asn Pro Lys Gln Thr 
65                  70                  75                  80  


Trp Val Lys Tyr Ile Val Arg Leu Leu Ser Lys Lys Val Lys Asn Met 
                85                  90                  95      


<210>  7
<211>  7686
<212>  DNA
<213>  Homo sapiens

<400>  7
tttatagcag cagtagaaat ataccaccct agaggacaca cctcctttta gctaggtacc       60

tataaatgtc caggattttc tattcaattg agaagaaccc agcaaaatgg ggatctccac      120

agtcatcctt gaaatgtgtc ttttatgggg acaagttcta tctacaggtg ggtggatccc      180

aaggactaca gactacgctt cactgattcc ctcggaggtg cccttggatc caactgtagc      240

agaaggttct ccatttccct cggagtcgac cctggagtca actgtagcag aaggttctcc      300

gatttccttg gagtcaaccc tggagtcaac cgtagcagaa ggttctctga ttccctcaga      360

gtcaaccctg gagtcaactg tagcagaagg atctgattct ggtttggccc tgaggctggt      420

gaatggagat ggcaggtgtc agggccgagt ggagatccta taccgaggct cctggggcac      480

cgtgtgtgat gacagctggg acaccaatga tgccaacgtg gtctgtaggc agctgggttg      540

tggctgggcc atgtcagctc caggaaatgc ctggtttggc cagggctcag gacccattgc      600

cctggatgat gtgcgctgct caggacacga atcctacctg tggagctgcc cccacaatgg      660

ctggctctcc cataactgtg gccatggtga agatgctggt gttatctgct cagctgccca      720

gcctcagtca acactcaggc cagaaagttg gcctgtcagg atatcaccac ctgtacccac      780

agaaggatct gaatccagtt tggccctgag gctggtgaat ggaggcgaca ggtgtcgagg      840

ccgagtggag gtcctatacc gaggctcctg gggcaccgtg tgtgatgact actgggacac      900

caatgatgcc aatgtggtct gcaggcagct gggctgtggc tgggccatgt cagccccagg      960

aaatgcccag tttggccagg gctcaggacc cattgtcctg gatgatgtgc gctgctcagg     1020

acatgagtcc tacctgtgga gctgccccca caatggctgg ctcacccaca actgtggcca     1080

tagtgaagac gctggtgtca tctgctcagc tccccagtcc cggccgacac ccagcccaga     1140

tacttggccg acctcacatg catcaacagc aggacctgaa tccagtttgg ccctgaggct     1200

ggtgaatgga ggtgacaggt gtcagggccg agtggaggtc ctataccgag gctcctgggg     1260

caccgtgtgt gatgatagct gggacaccag tgacgccaat gtggtctgcc ggcagctggg     1320

ctgtggctgg gccacgtcag ccccaggaaa tgcccggttt ggccagggtt caggacccat     1380

tgtcctggat gacgtgcgct gctcaggcta tgagtcctac ctgtggagct gcccccacaa     1440

tggctggctc tcccataact gtcagcacag tgaagacgct ggtgtcatct gctcagctgc     1500

ccactcctgg tcgacgccca gtccagacac gttgccgacc atcaccttac ctgcatcgac     1560

agtaggatct gaatccagtt tggccctgag gctggtgaat ggaggtgaca ggtgtcaggg     1620

ccgagtggag gtcctatacc gaggctcctg gggcaccgtg tgtgatgaca gctgggacac     1680

caatgatgcc aatgtggtct gcaggcagct gggctgtggc tgggccatgt tggccccagg     1740

aaatgcccgg tttggtcagg gctcaggacc cattgtcctg gatgacgtgc gctgctcagg     1800

gaatgagtcc tacttgtgga gctgccccca caatggctgg ctctcccata actgtggcca     1860

tagtgaagac gctggtgtca tctgctcagg acctgaatcc agtttggccc tgaggctggt     1920

gaatggaggt gacaggtgtc agggccgagt ggaggtccta taccgaggct cttggggcac     1980

cgtgtgtgat gacagctggg acaccaatga tgccaatgtg gtctgcaggc agctgggctg     2040

tggctgggcc acgtcagccc caggaaatgc ccggtttggt cagggctcag gacccattgt     2100

cctggatgat gtgcgctgct caggacatga gtcctacctg tggagctgcc ccaacaatgg     2160

ctggctctcc cacaactgtg gccatcatga agatgctggt gtcatctgct cagctgccca     2220

gtcccggtcg acgcccaggc cagacacgtt gtcgaccatc acgttacctc catcgacagt     2280

aggatctgaa tccagtttga ccctgaggct ggtgaatgga agtgacaggt gtcagggccg     2340

agtagaggtc ctataccgag gctcctgggg caccgtgtgt gatgacagct gggataccaa     2400

tgatgccaat gtggtctgca ggcagctggg ctgtggctgg gccacgtcgg ccccaggaaa     2460

tgcccggttt ggccagggct caggacccat tgttctggat gatgtgcgct gctcaggaca     2520

cgagtcctac ctgtggagct gcccccacaa tggctggctc tcccacaact gtggccatca     2580

tgaagatgct ggtgtcatct gctcagtttc ccagtcccgg ccgacaccca gtccagatac     2640

ttggccgacc tcacatgcat caacagcagg acctgaatcc agtttggccc tgaggctggt     2700

gaatggaggt gacaggtgtc agggccgagt ggaggtccta taccgaggct cctggggcac     2760

cgtgtgtgat gatagctggg acaccagtga cgccaatgtg gtctgccggc agctgggctg     2820

tggctgggcc acgtcagccc caggaaatgc ccggtttggc cagggttcag gacccattgt     2880

cctggatgac gtgcgctgct caggctatga gtcctacctg tggagctgcc cccacaatgg     2940

ctggctctcc cataactgtc agcacagtga agacgctggt gtcatctgct cagctgccca     3000

ctcctggtcg acgcccagtc cagacacatt gccgaccatc accttgcctg catcgacagt     3060

aggatctgaa tccagtttgg ccctgaggct ggtgaatgga ggtgacaggt gtcagggccg     3120

agtggaggtc ctataccaag gctcctgggg caccgtgtgc gatgacagct gggacaccaa     3180

tgatgccaat gtcgtctgca ggcaactggg ctgtggctgg gccatgtcag ccccaggaaa     3240

tgcccggttt ggtcagggct caggacccat tgtcctggat gatgtgcgct gctcaggaca     3300

cgagtcttac ctgtggagct gcccccacaa tggctggctc tcccacaact gtggccatag     3360

tgaagacgct ggtgtcatct gctcagcttc ccagtcccgg ccaacaccta gtccagacac     3420

ttggccaacc tcacatgcat caacagcagg atctgaatcc agtttggccc tgaggctggt     3480

gaatggaggt gacaggtgtc agggccgagt ggaggtccta taccgaggct cctggggcac     3540

cgtgtgtgat gactactggg acaccaatga tgccaatgtg gtttgcaggc agctgggctg     3600

tggctgggcc atgtcagccc caggaaatgc ccggtttggc cagggttcag gacccattgt     3660

cctggatgat gtgcgctgct caggacatga gtcctatctg tggagctgcc cccacaatgg     3720

ctggctctcc cacaactgtg gccatcatga agacgctggt gtcatctgct cagcttccca     3780

gtcccagccg acacccagcc cagacacttg gccaacctca catgcatcaa cagcaggatc     3840

tgaatccagt ttggccctga ggctggtgaa tggaggtgac aggtgtcagg gccgagtgga     3900

ggtcctatac cgaggctcct ggggcaccgt gtgtgatgac tactgggaca ccaatgatgc     3960

caatgtggtt tgcaggcagc tgggctgtgg ctgggccacg tcagccccag gaaatgcccg     4020

gtttggccag ggttcaggac ccattgtcct ggatgatgtg cgctgctcag gacatgagtc     4080

ctatctgtgg agctgccccc acaatggctg gctctcccac aactgtggcc atcatgaaga     4140

cgctggtgtc atctgctcag cttcccagtc ccagccgaca cccagcccag acacttggcc     4200

aacctcacat gcatcaacag caggatctga atccagtttg gccctgaggc tggtgaatgg     4260

aggtgacagg tgtcagggcc gagtggaggt cctataccga ggctcctggg gcaccgtgtg     4320

tgatgactac tgggacacca atgatgccaa tgtggtttgc aggcagctgg gctgtggctg     4380

ggccacgtca gccccaggaa atgcccggtt tggccagggt tcaggaccca ttgtcctgga     4440

tgatgtgcgc tgctcaggac atgagtccta tctgtggagc tgcccccaca atggctggct     4500

ctcccacaac tgtggccatc atgaagacgc tggtgtcatc tgctcagctt cccagtccca     4560

gccgacaccc agcccagaca cttggccaac ctctcgtgca tcaacagcag gatctgaatc     4620

cactttggcc ctgagactgg tgaatggagg tgacaggtgt cgaggccgag tggaggtcct     4680

ataccaaggc tcctggggca ccgtgtgtga tgactactgg gacaccaatg atgccaacgt     4740

ggtctgcagg cagctgggct gtggctgggc catgtcagcc ccaggaaatg cccagtttgg     4800

ccagggctca ggacccattg tcctggatga tgtgcgctgc tcaggacacg agtcttacct     4860

gtggagctgc ccccacaatg gctggctctc ccacaactgt ggccatcatg aagatgctgg     4920

tgtcatctgc tcagctgctc agtcccagtc aacgcccagg ccagatactt ggctgaccac     4980

caacttaccg gcattgacag taggatctga atccagtttg gctctgaggc tggtgaatgg     5040

aggtgacagg tgtcgaggcc gagtggaggt cctgtatcga ggctcctggg gaaccgtgtg     5100

tgatgacagc tgggacacca atgatgccaa tgtggtctgc aggcagctgg gctgtggctg     5160

ggccatgtcg gccccaggaa atgcccggtt tggccagggc tcaggaccca ttgtcctgga     5220

tgatgtgcgc tgctcaggga atgagtccta cctgtggagc tgcccccaca aaggctggct     5280

cacccacaac tgtggccatc acgaagacgc tggtgtcatc tgctcagcca cccaaataaa     5340

ttctactacg acagattggt ggcatccaac aactacaacc actgcaagac cctcttcaaa     5400

ttgtggtggc ttcttattct atgccagtgg gacattctcc agcccatcct accctgcata     5460

ctaccccaac aatgctaagt gtgtttggga aatagaagtg aattctggtt atcgcataaa     5520

cctgggcttc agtaatctga aattggaggc acaccataac tgcagttttg attatgttga     5580

aatctttgat ggatcattga atagcagtct cctgctgggg aaaatctgta atgataccag     5640

gcaaatattt acatcttctt acaaccgaat gaccattcac tttcgaagtg acatcagttt     5700

ccaaaacact ggctttttgg cttggtataa ctccttccca agcgatgcca ccttgaggtt     5760

ggtcaattta aattcatcct atggtctatg tgccgggcgt gtagaaattt accatggtgg     5820

cacctggggg acagtttgtg atgactcctg gaccattcag gaagctgagg tggtctgcag     5880

acagctaggg tgtggacgtg cagtttcagc ccttggaaat gcatattttg gctctggctc     5940

tggccccatc accctggacg atgtagagtg ctcagggacg gaatccactc tctggcagtg     6000

ccggaaccga ggctggttct cccacaactg taatcatcgt gaagatgctg gtgtcatctg     6060

ctcaggaaac catctatcga cacctgctcc ttttctcaac atcacccgtc caaacacaga     6120

ttattcctgc ggaggcttcc tatcccaacc atcaggggac ttttccagcc cattctatcc     6180

cgggaactat ccaaacaatg ccaagtgtgt gtgggacatt gaggtgcaaa acaactaccg     6240

tgtgactgtg atcttcagag atgtccagct tgaaggtggc tgcaactatg attatattga     6300

agttttcgat ggcccctacc gcagttcccc tctcattgct cgagtttgtg atggggccag     6360

aggctccttc acttcttcct ccaacttcat gtccattcgc ttcatcagtg accacagcat     6420

cacaaggaga gggttccggg ctgagtacta ctccagtccc tccaatgaca gcaccaacct     6480

gctctgtctg ccaaatcaca tgcaagccag tgtgagcagg agctatctcc aatccttggg     6540

cttttctgcc agtgaccttg tcatttccac ctggaatgga tactacgagt gtcggcccca     6600

gataacgccg aacctggtga tattcacaat tccctactca ggctgcggca ccttcaagca     6660

ggcagacaat gacaccatcg actattccaa cttcctcaca gcagctgtct caggtggcat     6720

catcaagagg aggacagacc tccgtattca cgtcagctgc agaatgcttc agaacacctg     6780

ggtcgacacc atgtacattg ctaatgacac catccacgtt gctaataaca ccatccaggt     6840

cgaggaagtc cagtatggca attttgacgt gaacatttcc ttttatactt cctcatcttt     6900

cttgtatcct gtgaccagcc gcccttacta cgtggacctg aaccaggact tgtacgttca     6960

ggctgaaatc ctccattctg atgctgtact gaccttgttt gtggacacct gcgtggcatc     7020

accatactcc aatgacttca cgtctttgac ttatgatcta atccggagtg gatgcgtgag     7080

ggatgacacc tacggaccct actcctcgcc atctcttcgc attgcccgct tccggttcag     7140

ggccttccac ttcctgaacc gcttcccctc cgtgtacctg cgttgtaaaa tggtggtgtg     7200

cagagcgtat gacccctctt cccgctgcta ccgaggctgt gtgttgaggt cgaagaggga     7260

tgtgggctcc taccaggaaa aggtggacgt cgtcctgggt cccatccagc tgcagacccc     7320

cccacgccga gaagaggagc ctcggtaggt ggtcgctctc agaccccact gtccaccggg     7380

gcgcagaccc ctgactcggg gacttgggat gttcctcttg gtgtcatatt ccaactcaga     7440

ttgagcccta cattgtgctg cacctggtca tacggagttg aatcagacct ggttcccgcc     7500

tcccccaagg ctcatggtcc ttggaggacc cgttgcaggg tgaggtcaag agagttctga     7560

cctggatggc ccatagacct gacgtcccag aatccatgct tctcatctgc aaaatgaaaa     7620

tgtcaatact tacttcttag cactgttgag agggttactt acataaagga attttggtga     7680

aactgc                                                                7686


<210>  8
<211>  2413
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(25)

<400>  8

Met Gly Ile Ser Thr Val Ile Leu Glu Met Cys Leu Leu Trp Gly Gln 
1               5                   10                  15      


Val Leu Ser Thr Gly Gly Trp Ile Pro Arg Thr Thr Asp Tyr Ala Ser 
            20                  25                  30          


Leu Ile Pro Ser Glu Val Pro Leu Asp Pro Thr Val Ala Glu Gly Ser 
        35                  40                  45              


Pro Phe Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
    50                  55                  60                  


Pro Ile Ser Leu Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
65                  70                  75                  80  


Leu Ile Pro Ser Glu Ser Thr Leu Glu Ser Thr Val Ala Glu Gly Ser 
                85                  90                  95      


Asp Ser Gly Leu Ala Leu Arg Leu Val Asn Gly Asp Gly Arg Cys Gln 
            100                 105                 110         


Gly Arg Val Glu Ile Leu Tyr Arg Gly Ser Trp Gly Thr Val Cys Asp 
        115                 120                 125             


Asp Ser Trp Asp Thr Asn Asp Ala Asn Val Val Cys Arg Gln Leu Gly 
    130                 135                 140                 


Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Trp Phe Gly Gln Gly 
145                 150                 155                 160 


Ser Gly Pro Ile Ala Leu Asp Asp Val Arg Cys Ser Gly His Glu Ser 
                165                 170                 175     


Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Ser His Asn Cys Gly 
            180                 185                 190         


His Gly Glu Asp Ala Gly Val Ile Cys Ser Ala Ala Gln Pro Gln Ser 
        195                 200                 205             


Thr Leu Arg Pro Glu Ser Trp Pro Val Arg Ile Ser Pro Pro Val Pro 
    210                 215                 220                 


Thr Glu Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly 
225                 230                 235                 240 


Asp Arg Cys Arg Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly 
                245                 250                 255     


Thr Val Cys Asp Asp Tyr Trp Asp Thr Asn Asp Ala Asn Val Val Cys 
            260                 265                 270         


Arg Gln Leu Gly Cys Gly Trp Ala Met Ser Ala Pro Gly Asn Ala Gln 
        275                 280                 285             


Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser 
    290                 295                 300                 


Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu Thr 
305                 310                 315                 320 


His Asn Cys Gly His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala Pro 
                325                 330                 335     


Gln Ser Arg Pro Thr Pro Ser Pro Asp Thr Trp Pro Thr Ser His Ala 
            340                 345                 350         


Ser Thr Ala Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly 
        355                 360                 365             


Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp 
    370                 375                 380                 


Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Ser Asp Ala Asn Val Val 
385                 390                 395                 400 


Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly Asn Ala 
                405                 410                 415     


Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys 
            420                 425                 430         


Ser Gly Tyr Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly Trp Leu 
        435                 440                 445             


Ser His Asn Cys Gln His Ser Glu Asp Ala Gly Val Ile Cys Ser Ala 
    450                 455                 460                 


Ala His Ser Trp Ser Thr Pro Ser Pro Asp Thr Leu Pro Thr Ile Thr 
465                 470                 475                 480 


Leu Pro Ala Ser Thr Val Gly Ser Glu Ser Ser Leu Ala Leu Arg Leu 
                485                 490                 495     


Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg 
            500                 505                 510         


Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala 
        515                 520                 525             


Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Met Leu Ala Pro 
    530                 535                 540                 


Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp 
545                 550                 555                 560 


Val Arg Cys Ser Gly Asn Glu Ser Tyr Leu Trp Ser Cys Pro His Asn 
                565                 570                 575     


Gly Trp Leu Ser His Asn Cys Gly His Ser Glu Asp Ala Gly Val Ile 
            580                 585                 590         


Cys Ser Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu Val Asn Gly Gly 
        595                 600                 605             


Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly Ser Trp Gly 
    610                 615                 620                 


Thr Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala Asn Val Val Cys 
625                 630                 635                 640 


Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly Asn Ala Arg 
                645                 650                 655     


Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val Arg Cys Ser 
            660                 665                 670         


Gly His Glu Ser Tyr Leu Trp Ser Cys Pro Asn Asn Gly Trp Leu Ser 
        675                 680                 685             


His Asn Cys Gly His His Glu Asp Ala Gly Val Ile Cys Ser Ala Ala 
    690                 695                 700                 


Gln Ser Arg Ser Thr Pro Arg Pro Asp Thr Leu Ser Thr Ile Thr Leu 
705                 710                 715                 720 


Pro Pro Ser Thr Val Gly Ser Glu Ser Ser Leu Thr Leu Arg Leu Val 
                725                 730                 735     


Asn Gly Ser Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg Gly 
            740                 745                 750         


Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Asn Asp Ala Asn 
        755                 760                 765             


Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro Gly 
    770                 775                 780                 


Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp Val 
785                 790                 795                 800 


Arg Cys Ser Gly His Glu Ser Tyr Leu Trp Ser Cys Pro His Asn Gly 
                805                 810                 815     


Trp Leu Ser His Asn Cys Gly His His Glu Asp Ala Gly Val Ile Cys 
            820                 825                 830         


Ser Val Ser Gln Ser Arg Pro Thr Pro Ser Pro Asp Thr Trp Pro Thr 
        835                 840                 845             


Ser His Ala Ser Thr Ala Gly Pro Glu Ser Ser Leu Ala Leu Arg Leu 
    850                 855                 860                 


Val Asn Gly Gly Asp Arg Cys Gln Gly Arg Val Glu Val Leu Tyr Arg 
865                 870                 875                 880 


Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Thr Ser Asp Ala 
                885                 890                 895     


Asn Val Val Cys Arg Gln Leu Gly Cys Gly Trp Ala Thr Ser Ala Pro 
            900                 905                 910         


Gly Asn Ala Arg Phe Gly Gln Gly Ser Gly Pro Ile Val Leu Asp Asp 
        915                 920                 925             


Val Arg Cys Ser Gly Tyr Glu Ser Tyr Leu Trp Ser Cys Pro His Asn 
    930                 935                 940                 


Gly Trp Leu Ser His Asn Cys Gln His Ser Glu Asp Ala Gly Val Ile 
945                 950                 955                 960 


Cys Ser Ala Ala His Ser Trp Ser Thr Pro Ser Pro Asp Thr Leu Pro 
                965                 970                 975     


Thr Ile Thr Leu Pro Ala Ser Thr Val Gly Ser Glu Ser Ser Leu Ala 
            980                 985                 990         


Leu Arg Leu Val Asn Gly Gly Asp  Arg Cys Gln Gly Arg  Val Glu Val 
        995                 1000                 1005             


Leu Tyr  Gln Gly Ser Trp Gly  Thr Val Cys Asp Asp  Ser Trp Asp 
    1010                 1015                 1020             


Thr Asn  Asp Ala Asn Val Val  Cys Arg Gln Leu Gly  Cys Gly Trp 
    1025                 1030                 1035             


Ala Met  Ser Ala Pro Gly Asn  Ala Arg Phe Gly Gln  Gly Ser Gly 
    1040                 1045                 1050             


Pro Ile  Val Leu Asp Asp Val  Arg Cys Ser Gly His  Glu Ser Tyr 
    1055                 1060                 1065             


Leu Trp  Ser Cys Pro His Asn  Gly Trp Leu Ser His  Asn Cys Gly 
    1070                 1075                 1080             


His Ser  Glu Asp Ala Gly Val  Ile Cys Ser Ala Ser  Gln Ser Arg 
    1085                 1090                 1095             


Pro Thr  Pro Ser Pro Asp Thr  Trp Pro Thr Ser His  Ala Ser Thr 
    1100                 1105                 1110             


Ala Gly  Ser Glu Ser Ser Leu  Ala Leu Arg Leu Val  Asn Gly Gly 
    1115                 1120                 1125             


Asp Arg  Cys Gln Gly Arg Val  Glu Val Leu Tyr Arg  Gly Ser Trp 
    1130                 1135                 1140             


Gly Thr  Val Cys Asp Asp Tyr  Trp Asp Thr Asn Asp  Ala Asn Val 
    1145                 1150                 1155             


Val Cys  Arg Gln Leu Gly Cys  Gly Trp Ala Met Ser  Ala Pro Gly 
    1160                 1165                 1170             


Asn Ala  Arg Phe Gly Gln Gly  Ser Gly Pro Ile Val  Leu Asp Asp 
    1175                 1180                 1185             


Val Arg  Cys Ser Gly His Glu  Ser Tyr Leu Trp Ser  Cys Pro His 
    1190                 1195                 1200             


Asn Gly  Trp Leu Ser His Asn  Cys Gly His His Glu  Asp Ala Gly 
    1205                 1210                 1215             


Val Ile  Cys Ser Ala Ser Gln  Ser Gln Pro Thr Pro  Ser Pro Asp 
    1220                 1225                 1230             


Thr Trp  Pro Thr Ser His Ala  Ser Thr Ala Gly Ser  Glu Ser Ser 
    1235                 1240                 1245             


Leu Ala  Leu Arg Leu Val Asn  Gly Gly Asp Arg Cys  Gln Gly Arg 
    1250                 1255                 1260             


Val Glu  Val Leu Tyr Arg Gly  Ser Trp Gly Thr Val  Cys Asp Asp 
    1265                 1270                 1275             


Tyr Trp  Asp Thr Asn Asp Ala  Asn Val Val Cys Arg  Gln Leu Gly 
    1280                 1285                 1290             


Cys Gly  Trp Ala Thr Ser Ala  Pro Gly Asn Ala Arg  Phe Gly Gln 
    1295                 1300                 1305             


Gly Ser  Gly Pro Ile Val Leu  Asp Asp Val Arg Cys  Ser Gly His 
    1310                 1315                 1320             


Glu Ser  Tyr Leu Trp Ser Cys  Pro His Asn Gly Trp  Leu Ser His 
    1325                 1330                 1335             


Asn Cys  Gly His His Glu Asp  Ala Gly Val Ile Cys  Ser Ala Ser 
    1340                 1345                 1350             


Gln Ser  Gln Pro Thr Pro Ser  Pro Asp Thr Trp Pro  Thr Ser His 
    1355                 1360                 1365             


Ala Ser  Thr Ala Gly Ser Glu  Ser Ser Leu Ala Leu  Arg Leu Val 
    1370                 1375                 1380             


Asn Gly  Gly Asp Arg Cys Gln  Gly Arg Val Glu Val  Leu Tyr Arg 
    1385                 1390                 1395             


Gly Ser  Trp Gly Thr Val Cys  Asp Asp Tyr Trp Asp  Thr Asn Asp 
    1400                 1405                 1410             


Ala Asn  Val Val Cys Arg Gln  Leu Gly Cys Gly Trp  Ala Thr Ser 
    1415                 1420                 1425             


Ala Pro  Gly Asn Ala Arg Phe  Gly Gln Gly Ser Gly  Pro Ile Val 
    1430                 1435                 1440             


Leu Asp  Asp Val Arg Cys Ser  Gly His Glu Ser Tyr  Leu Trp Ser 
    1445                 1450                 1455             


Cys Pro  His Asn Gly Trp Leu  Ser His Asn Cys Gly  His His Glu 
    1460                 1465                 1470             


Asp Ala  Gly Val Ile Cys Ser  Ala Ser Gln Ser Gln  Pro Thr Pro 
    1475                 1480                 1485             


Ser Pro  Asp Thr Trp Pro Thr  Ser Arg Ala Ser Thr  Ala Gly Ser 
    1490                 1495                 1500             


Glu Ser  Thr Leu Ala Leu Arg  Leu Val Asn Gly Gly  Asp Arg Cys 
    1505                 1510                 1515             


Arg Gly  Arg Val Glu Val Leu  Tyr Gln Gly Ser Trp  Gly Thr Val 
    1520                 1525                 1530             


Cys Asp  Asp Tyr Trp Asp Thr  Asn Asp Ala Asn Val  Val Cys Arg 
    1535                 1540                 1545             


Gln Leu  Gly Cys Gly Trp Ala  Met Ser Ala Pro Gly  Asn Ala Gln 
    1550                 1555                 1560             


Phe Gly  Gln Gly Ser Gly Pro  Ile Val Leu Asp Asp  Val Arg Cys 
    1565                 1570                 1575             


Ser Gly  His Glu Ser Tyr Leu  Trp Ser Cys Pro His  Asn Gly Trp 
    1580                 1585                 1590             


Leu Ser  His Asn Cys Gly His  His Glu Asp Ala Gly  Val Ile Cys 
    1595                 1600                 1605             


Ser Ala  Ala Gln Ser Gln Ser  Thr Pro Arg Pro Asp  Thr Trp Leu 
    1610                 1615                 1620             


Thr Thr  Asn Leu Pro Ala Leu  Thr Val Gly Ser Glu  Ser Ser Leu 
    1625                 1630                 1635             


Ala Leu  Arg Leu Val Asn Gly  Gly Asp Arg Cys Arg  Gly Arg Val 
    1640                 1645                 1650             


Glu Val  Leu Tyr Arg Gly Ser  Trp Gly Thr Val Cys  Asp Asp Ser 
    1655                 1660                 1665             


Trp Asp  Thr Asn Asp Ala Asn  Val Val Cys Arg Gln  Leu Gly Cys 
    1670                 1675                 1680             


Gly Trp  Ala Met Ser Ala Pro  Gly Asn Ala Arg Phe  Gly Gln Gly 
    1685                 1690                 1695             


Ser Gly  Pro Ile Val Leu Asp  Asp Val Arg Cys Ser  Gly Asn Glu 
    1700                 1705                 1710             


Ser Tyr  Leu Trp Ser Cys Pro  His Lys Gly Trp Leu  Thr His Asn 
    1715                 1720                 1725             


Cys Gly  His His Glu Asp Ala  Gly Val Ile Cys Ser  Ala Thr Gln 
    1730                 1735                 1740             


Ile Asn  Ser Thr Thr Thr Asp  Trp Trp His Pro Thr  Thr Thr Thr 
    1745                 1750                 1755             


Thr Ala  Arg Pro Ser Ser Asn  Cys Gly Gly Phe Leu  Phe Tyr Ala 
    1760                 1765                 1770             


Ser Gly  Thr Phe Ser Ser Pro  Ser Tyr Pro Ala Tyr  Tyr Pro Asn 
    1775                 1780                 1785             


Asn Ala  Lys Cys Val Trp Glu  Ile Glu Val Asn Ser  Gly Tyr Arg 
    1790                 1795                 1800             


Ile Asn  Leu Gly Phe Ser Asn  Leu Lys Leu Glu Ala  His His Asn 
    1805                 1810                 1815             


Cys Ser  Phe Asp Tyr Val Glu  Ile Phe Asp Gly Ser  Leu Asn Ser 
    1820                 1825                 1830             


Ser Leu  Leu Leu Gly Lys Ile  Cys Asn Asp Thr Arg  Gln Ile Phe 
    1835                 1840                 1845             


Thr Ser  Ser Tyr Asn Arg Met  Thr Ile His Phe Arg  Ser Asp Ile 
    1850                 1855                 1860             


Ser Phe  Gln Asn Thr Gly Phe  Leu Ala Trp Tyr Asn  Ser Phe Pro 
    1865                 1870                 1875             


Ser Asp  Ala Thr Leu Arg Leu  Val Asn Leu Asn Ser  Ser Tyr Gly 
    1880                 1885                 1890             


Leu Cys  Ala Gly Arg Val Glu  Ile Tyr His Gly Gly  Thr Trp Gly 
    1895                 1900                 1905             


Thr Val  Cys Asp Asp Ser Trp  Thr Ile Gln Glu Ala  Glu Val Val 
    1910                 1915                 1920             


Cys Arg  Gln Leu Gly Cys Gly  Arg Ala Val Ser Ala  Leu Gly Asn 
    1925                 1930                 1935             


Ala Tyr  Phe Gly Ser Gly Ser  Gly Pro Ile Thr Leu  Asp Asp Val 
    1940                 1945                 1950             


Glu Cys  Ser Gly Thr Glu Ser  Thr Leu Trp Gln Cys  Arg Asn Arg 
    1955                 1960                 1965             


Gly Trp  Phe Ser His Asn Cys  Asn His Arg Glu Asp  Ala Gly Val 
    1970                 1975                 1980             


Ile Cys  Ser Gly Asn His Leu  Ser Thr Pro Ala Pro  Phe Leu Asn 
    1985                 1990                 1995             


Ile Thr  Arg Pro Asn Thr Asp  Tyr Ser Cys Gly Gly  Phe Leu Ser 
    2000                 2005                 2010             


Gln Pro  Ser Gly Asp Phe Ser  Ser Pro Phe Tyr Pro  Gly Asn Tyr 
    2015                 2020                 2025             


Pro Asn  Asn Ala Lys Cys Val  Trp Asp Ile Glu Val  Gln Asn Asn 
    2030                 2035                 2040             


Tyr Arg  Val Thr Val Ile Phe  Arg Asp Val Gln Leu  Glu Gly Gly 
    2045                 2050                 2055             


Cys Asn  Tyr Asp Tyr Ile Glu  Val Phe Asp Gly Pro  Tyr Arg Ser 
    2060                 2065                 2070             


Ser Pro  Leu Ile Ala Arg Val  Cys Asp Gly Ala Arg  Gly Ser Phe 
    2075                 2080                 2085             


Thr Ser  Ser Ser Asn Phe Met  Ser Ile Arg Phe Ile  Ser Asp His 
    2090                 2095                 2100             


Ser Ile  Thr Arg Arg Gly Phe  Arg Ala Glu Tyr Tyr  Ser Ser Pro 
    2105                 2110                 2115             


Ser Asn  Asp Ser Thr Asn Leu  Leu Cys Leu Pro Asn  His Met Gln 
    2120                 2125                 2130             


Ala Ser  Val Ser Arg Ser Tyr  Leu Gln Ser Leu Gly  Phe Ser Ala 
    2135                 2140                 2145             


Ser Asp  Leu Val Ile Ser Thr  Trp Asn Gly Tyr Tyr  Glu Cys Arg 
    2150                 2155                 2160             


Pro Gln  Ile Thr Pro Asn Leu  Val Ile Phe Thr Ile  Pro Tyr Ser 
    2165                 2170                 2175             


Gly Cys  Gly Thr Phe Lys Gln  Ala Asp Asn Asp Thr  Ile Asp Tyr 
    2180                 2185                 2190             


Ser Asn  Phe Leu Thr Ala Ala  Val Ser Gly Gly Ile  Ile Lys Arg 
    2195                 2200                 2205             


Arg Thr  Asp Leu Arg Ile His  Val Ser Cys Arg Met  Leu Gln Asn 
    2210                 2215                 2220             


Thr Trp  Val Asp Thr Met Tyr  Ile Ala Asn Asp Thr  Ile His Val 
    2225                 2230                 2235             


Ala Asn  Asn Thr Ile Gln Val  Glu Glu Val Gln Tyr  Gly Asn Phe 
    2240                 2245                 2250             


Asp Val  Asn Ile Ser Phe Tyr  Thr Ser Ser Ser Phe  Leu Tyr Pro 
    2255                 2260                 2265             


Val Thr  Ser Arg Pro Tyr Tyr  Val Asp Leu Asn Gln  Asp Leu Tyr 
    2270                 2275                 2280             


Val Gln  Ala Glu Ile Leu His  Ser Asp Ala Val Leu  Thr Leu Phe 
    2285                 2290                 2295             


Val Asp  Thr Cys Val Ala Ser  Pro Tyr Ser Asn Asp  Phe Thr Ser 
    2300                 2305                 2310             


Leu Thr  Tyr Asp Leu Ile Arg  Ser Gly Cys Val Arg  Asp Asp Thr 
    2315                 2320                 2325             


Tyr Gly  Pro Tyr Ser Ser Pro  Ser Leu Arg Ile Ala  Arg Phe Arg 
    2330                 2335                 2340             


Phe Arg  Ala Phe His Phe Leu  Asn Arg Phe Pro Ser  Val Tyr Leu 
    2345                 2350                 2355             


Arg Cys  Lys Met Val Val Cys  Arg Ala Tyr Asp Pro  Ser Ser Arg 
    2360                 2365                 2370             


Cys Tyr  Arg Gly Cys Val Leu  Arg Ser Lys Arg Asp  Val Gly Ser 
    2375                 2380                 2385             


Tyr Gln  Glu Lys Val Asp Val  Val Leu Gly Pro Ile  Gln Leu Gln 
    2390                 2395                 2400             


Thr Pro  Pro Arg Arg Glu Glu  Glu Pro Arg 
    2405                 2410             


<210>  9
<211>  560
<212>  DNA
<213>  Homo sapiens

<400>  9
accacagtgg tgtccgagaa gtcaggcacg tagctcagcg gcggccgcgg cgcgtgcgtc       60

tgtgcctctg cgcgggtctc ctggtccttc tgccatcatg ccgatgttca tcgtaaacac      120

caacgtgccc cgcgcctccg tgccggacgg gttcctctcc gagctcaccc agcagctggc      180

gcaggccacc ggcaagcccc cccagtacat cgcggtgcac gtggtcccgg accagctcat      240

ggccttcggc ggctccagcg agccgtgcgc gctctgcagc ctgcacagca tcggcaagat      300

cggcggcgcg cagaaccgct cctacagcaa gctgctgtgc ggcctgctgg ccgagcgcct      360

gcgcatcagc ccggacaggg tctacatcaa ctattacgac atgaacgcgg ccaatgtggg      420

ctggaacaac tccaccttcg cctaagagcc gcagggaccc acgctgtctg cgctggctcc      480

acccgggaac ccgccgcacg ctgtgttcta ggcccgccca ccccaacctt ctggtgggga      540

gaaataaacg gtttagagac                                                  560


<210>  10
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Pro Met Phe Ile Val Asn Thr Asn Val Pro Arg Ala Ser Val Pro 
1               5                   10                  15      


Asp Gly Phe Leu Ser Glu Leu Thr Gln Gln Leu Ala Gln Ala Thr Gly 
            20                  25                  30          


Lys Pro Pro Gln Tyr Ile Ala Val His Val Val Pro Asp Gln Leu Met 
        35                  40                  45              


Ala Phe Gly Gly Ser Ser Glu Pro Cys Ala Leu Cys Ser Leu His Ser 
    50                  55                  60                  


Ile Gly Lys Ile Gly Gly Ala Gln Asn Arg Ser Tyr Ser Lys Leu Leu 
65                  70                  75                  80  


Cys Gly Leu Leu Ala Glu Arg Leu Arg Ile Ser Pro Asp Arg Val Tyr 
                85                  90                  95      


Ile Asn Tyr Tyr Asp Met Asn Ala Ala Asn Val Gly Trp Asn Asn Ser 
            100                 105                 110         


Thr Phe Ala 
        115 


<210>  11
<211>  840
<212>  DNA
<213>  Homo sapiens

<400>  11
actcgccacc tcctcttcca cccctgccag gcccagcagc caccacagcg cctgcttcct       60

cggccctgaa atcatgcccc taggtctcct gtggctgggc ctagccctgt tgggggctct      120

gcatgcccag gcccaggact ccacctcaga cctgatccca gccccacctc tgagcaaggt      180

ccctctgcag cagaacttcc aggacaacca attccagggg aagtggtatg tggtaggcct      240

ggcagggaat gcaattctca gagaagacaa agacccgcaa aagatgtatg ccaccatcta      300

tgagctgaaa gaagacaaga gctacaatgt cacctccgtc ctgtttagga aaaagaagtg      360

tgactactgg atcaggactt ttgttccagg ttgccagccc ggcgagttca cgctgggcaa      420

cattaagagt taccctggat taacgagtta cctcgtccga gtggtgagca ccaactacaa      480

ccagcatgct atggtgttct tcaagaaagt ttctcaaaac agggagtact tcaagatcac      540

cctctacggg agaaccaagg agctgacttc ggaactaaag gagaacttca tccgcttctc      600

caaatctctg ggcctccctg aaaaccacat cgtcttccct gtcccaatcg accagtgtat      660

cgacggctga gtgcacaggt gccgccagct gccgcaccag cccgaacacc attgagggag      720

ctgggagacc ctccccacag tgccacccat gcagctgctc cccaggccac cccgctgatg      780

gagccccacc ttgtctgcta aataaacatg tgccctcagg ccaaaaaaaa aaaaaaaaaa      840


<210>  12
<211>  198
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(20)

<400>  12

Met Pro Leu Gly Leu Leu Trp Leu Gly Leu Ala Leu Leu Gly Ala Leu 
1               5                   10                  15      


His Ala Gln Ala Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro 
            20                  25                  30          


Leu Ser Lys Val Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe Gln 
        35                  40                  45              


Gly Lys Trp Tyr Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu 
    50                  55                  60                  


Asp Lys Asp Pro Gln Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu 
65                  70                  75                  80  


Asp Lys Ser Tyr Asn Val Thr Ser Val Leu Phe Arg Lys Lys Lys Cys 
                85                  90                  95      


Asp Tyr Trp Ile Arg Thr Phe Val Pro Gly Cys Gln Pro Gly Glu Phe 
            100                 105                 110         


Thr Leu Gly Asn Ile Lys Ser Tyr Pro Gly Leu Thr Ser Tyr Leu Val 
        115                 120                 125             


Arg Val Val Ser Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys 
    130                 135                 140                 


Lys Val Ser Gln Asn Arg Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg 
145                 150                 155                 160 


Thr Lys Glu Leu Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser 
                165                 170                 175     


Lys Ser Leu Gly Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile 
            180                 185                 190         


Asp Gln Cys Ile Asp Gly 
        195             


<210>  13
<211>  1002
<212>  DNA
<213>  Homo sapiens

<400>  13
gggagggtcc cttcctcagg gagcacagga actctgagac tcagcaaggg tgtcctggga       60

gggctcgggg atgggagagt acacagattc acaactcatt cagaactgta gaagatgatg      120

gatgtgacca agatcacttt agtcctaggg gactagagaa ggaaaatgac atgaggcagt      180

ggggtatctg tgtgttctcc cactgaccac gctttcttta gtgactcctg attgcctcct      240

caagtcgcag acactatgct gcctcccatg gccctgccca gtgtatcttg gatgctgctt      300

tcctgcctca tgctgctgtc tcaggttcaa ggtgaagaac cccagaggga actgccctct      360

gcacggatcc gctgtcccaa aggctccaag gcctatggct cccactgcta tgccttgttt      420

ttgtcaccaa aatcctggac agatgcagat ctggcctgcc agaagcggcc ctctggaaac      480

ctggtgtctg tgctcagtgg ggctgaggga tccttcgtgt cctccctggt gaagagcatt      540

ggtaacagct actcatacgt ctggattggg ctccatgacc ccacacaggg caccgagccc      600

aatggagaag gttgggagtg gagtagcagt gatgtgatga attactttgc atgggagaga      660

aatccctcca ccatctcaag ccccggccac tgtgcgagcc tgtcgagaag cacagcattt      720

ctgaggtgga aagattataa ctgtaatgtg aggttaccct atgtctgcaa gttcactgac      780

tagtgcagga gggaagtcag cagcctgtgt ttggtgtgca actcatcatg ggcatgagac      840

cagtgtgagg actcaccctg gaagagaata ttcgcttaat tcccccaacc tgaccacctc      900

attcttatct ttcttctgtt tcttcctccc cgctgtcatt tcagtctctt cattttgtca      960

tacggcctaa ggctttaaag agcaataaaa tttttagtct gc                        1002


<210>  14
<211>  175
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(26)

<400>  14

Met Leu Pro Pro Met Ala Leu Pro Ser Val Ser Trp Met Leu Leu Ser 
1               5                   10                  15      


Cys Leu Met Leu Leu Ser Gln Val Gln Gly Glu Glu Pro Gln Arg Glu 
            20                  25                  30          


Leu Pro Ser Ala Arg Ile Arg Cys Pro Lys Gly Ser Lys Ala Tyr Gly 
        35                  40                  45              


Ser His Cys Tyr Ala Leu Phe Leu Ser Pro Lys Ser Trp Thr Asp Ala 
    50                  55                  60                  


Asp Leu Ala Cys Gln Lys Arg Pro Ser Gly Asn Leu Val Ser Val Leu 
65                  70                  75                  80  


Ser Gly Ala Glu Gly Ser Phe Val Ser Ser Leu Val Lys Ser Ile Gly 
                85                  90                  95      


Asn Ser Tyr Ser Tyr Val Trp Ile Gly Leu His Asp Pro Thr Gln Gly 
            100                 105                 110         


Thr Glu Pro Asn Gly Glu Gly Trp Glu Trp Ser Ser Ser Asp Val Met 
        115                 120                 125             


Asn Tyr Phe Ala Trp Glu Arg Asn Pro Ser Thr Ile Ser Ser Pro Gly 
    130                 135                 140                 


His Cys Ala Ser Leu Ser Arg Ser Thr Ala Phe Leu Arg Trp Lys Asp 
145                 150                 155                 160 


Tyr Asn Cys Asn Val Arg Leu Pro Tyr Val Cys Lys Phe Thr Asp 
                165                 170                 175 


<210>  15
<211>  947
<212>  DNA
<213>  Homo sapiens

<400>  15
ccatccctga gatcttttta taaaaaaccc agtctttgct gaccagacaa agcataccag       60

atctcaccag agagtcctag gggactacag aaggaaaaag acaagaggca gtaggatatc      120

tgtgtgtcct cccgctgacc acacttcctt tagtgacccg attgcctcct caagtcgcag      180

acactatgct gcctcccatg gccctgccca gtgtgtcctg gatgctgctt tcctgcctca      240

ttctcctgtg tcaggttcaa ggtgaagaaa cccagaagga actgccctct ccacggatca      300

gctgtcccaa aggctccaag gcctatggct ccccctgcta tgccttgttt ttgtcaccaa      360

aatcctggat ggatgcagat ctggcttgcc agaagcggcc ctctggaaaa ctggtgtctg      420

tgctcagtgg ggctgaggga tccttcgtgt cctccctggt gaggagcatt agtaacagct      480

attcatacat ctggattggg ctccatgacc ccacacaggg ctctgagcct gatggagatg      540

gatgggagtg gagtagcact gatgtgatga attactttgc atgggagaaa aatccctcca      600

ccatcttaaa ccctggccac tgtgggagcc tgtcaagaag cacaggattt ctgaagtgga      660

aagattataa ctgtgatgca aagttaccct atgtctgcaa gttcaaggac tagggcaggt      720

gggaagtcag cagcctgagc ttggcgtgca gctcatcatg gacatgagac cagtgtgaag      780

actcaccctg gaagagaata ttctccccaa actgccctac ctgactacct tgtcatgatc      840

ctccttcttt ttcctttttc ttcaccttca tttcaggctt ttctctgtct tccatgtctt      900

gagatctcag agaataataa taaaaatgtt actttatacg taaaaaa                    947


<210>  16
<211>  175
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(26)

<400>  16

Met Leu Pro Pro Met Ala Leu Pro Ser Val Ser Trp Met Leu Leu Ser 
1               5                   10                  15      


Cys Leu Ile Leu Leu Cys Gln Val Gln Gly Glu Glu Thr Gln Lys Glu 
            20                  25                  30          


Leu Pro Ser Pro Arg Ile Ser Cys Pro Lys Gly Ser Lys Ala Tyr Gly 
        35                  40                  45              


Ser Pro Cys Tyr Ala Leu Phe Leu Ser Pro Lys Ser Trp Met Asp Ala 
    50                  55                  60                  


Asp Leu Ala Cys Gln Lys Arg Pro Ser Gly Lys Leu Val Ser Val Leu 
65                  70                  75                  80  


Ser Gly Ala Glu Gly Ser Phe Val Ser Ser Leu Val Arg Ser Ile Ser 
                85                  90                  95      


Asn Ser Tyr Ser Tyr Ile Trp Ile Gly Leu His Asp Pro Thr Gln Gly 
            100                 105                 110         


Ser Glu Pro Asp Gly Asp Gly Trp Glu Trp Ser Ser Thr Asp Val Met 
        115                 120                 125             


Asn Tyr Phe Ala Trp Glu Lys Asn Pro Ser Thr Ile Leu Asn Pro Gly 
    130                 135                 140                 


His Cys Gly Ser Leu Ser Arg Ser Thr Gly Phe Leu Lys Trp Lys Asp 
145                 150                 155                 160 


Tyr Asn Cys Asp Ala Lys Leu Pro Tyr Val Cys Lys Phe Lys Asp 
                165                 170                 175 


<210>  17
<211>  428
<212>  DNA
<213>  Homo sapiens

<400>  17
atgtctcttg tcagctgtct ttcagaagac ctggtggggc aagtccgtgg gcatcatgtt       60

gaccgagctg gagaaagcct tgaactctat catcgacgtc taccacaagt actccctgat      120

aaaggggaat ttccatgccg tctacaggga tgacctgaag aaattgctag agaccgagtg      180

tcctcagtat atcaggaaaa agggtgcaga cgtctggttc aaagagttgg atatcaacac      240

tgatggtgca gttaacttcc aggagttcct cattctggtg ataaagatgg gcgtggcagc      300

ccacaaaaaa agccatgaag aaagccacaa agagtagctg agttactggg cccagaggct      360

gggcccctgg acatgtacct gcagaataat aaagtcatca atacctcaaa aaaaaaaaaa      420

aaaaaaaa                                                               428


<210>  18
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Leu Thr Glu Leu Glu Lys Ala Leu Asn Ser Ile Ile Asp Val Tyr 
1               5                   10                  15      


His Lys Tyr Ser Leu Ile Lys Gly Asn Phe His Ala Val Tyr Arg Asp 
            20                  25                  30          


Asp Leu Lys Lys Leu Leu Glu Thr Glu Cys Pro Gln Tyr Ile Arg Lys 
        35                  40                  45              


Lys Gly Ala Asp Val Trp Phe Lys Glu Leu Asp Ile Asn Thr Asp Gly 
    50                  55                  60                  


Ala Val Asn Phe Gln Glu Phe Leu Ile Leu Val Ile Lys Met Gly Val 
65                  70                  75                  80  


Ala Ala His Lys Lys Ser His Glu Glu Ser His Lys Glu 
                85                  90              


<210>  19
<211>  586
<212>  DNA
<213>  Homo sapiens

<400>  19
aaacactctg tgtggctcct cggctttgac agagtgcaag acgatgactt gcaaaatgtc       60

gcagctggaa cgcaacatag agaccatcat caacaccttc caccaatact ctgtgaagct      120

ggggcaccca gacaccctga accaggggga attcaaagag ctggtgcgaa aagatctgca      180

aaattttctc aagaaggaga ataagaatga aaaggtcata gaacacatca tggaggacct      240

ggacacaaat gcagacaagc agctgagctt cgaggagttc atcatgctga tggcgaggct      300

aacctgggcc tcccacgaga agatgcacga gggtgacgag ggccctggcc accaccataa      360

gccaggcctc ggggagggca ccccctaaga ccacagtggc caagatcaca gtggccacgg      420

ccacggccac agtcatggtg gccacggcca cagccactaa tcaggaggcc aggccaccct      480

gcctctaccc aaccagggcc ccggggcctg ttatgtcaaa ctgtcttggc tgtggggcta      540

ggggctgggg ccaaataaag tctcttcctc caagtcaaaa aaaaaa                     586


<210>  20
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Thr Cys Lys Met Ser Gln Leu Glu Arg Asn Ile Glu Thr Ile Ile 
1               5                   10                  15      


Asn Thr Phe His Gln Tyr Ser Val Lys Leu Gly His Pro Asp Thr Leu 
            20                  25                  30          


Asn Gln Gly Glu Phe Lys Glu Leu Val Arg Lys Asp Leu Gln Asn Phe 
        35                  40                  45              


Leu Lys Lys Glu Asn Lys Asn Glu Lys Val Ile Glu His Ile Met Glu 
    50                  55                  60                  


Asp Leu Asp Thr Asn Ala Asp Lys Gln Leu Ser Phe Glu Glu Phe Ile 
65                  70                  75                  80  


Met Leu Met Ala Arg Leu Thr Trp Ala Ser His Glu Lys Met His Glu 
                85                  90                  95      


Gly Asp Glu Gly Pro Gly His His His Lys Pro Gly Leu Gly Glu Gly 
            100                 105                 110         


Thr Pro 
        


<210>  21
<211>  1147
<212>  DNA
<213>  Homo sapiens

<400>  21
cgaccaggtt ctccttcccc agtcaccagt tgctcgagtt agaattgtct gcaatggccg       60

ccctgcagaa atctgtgagc tctttcctta tggggaccct ggccaccagc tgcctccttc      120

tcttggccct cttggtacag ggaggagcag ctgcgcccat cagctcccac tgcaggcttg      180

acaagtccaa cttccagcag ccctatatca ccaaccgcac cttcatgctg gctaaggagg      240

ctagcttggc tgataacaac acagacgttc gtctcattgg ggagaaactg ttccacggag      300

tcagtatgag tgagcgctgc tatctgatga agcaggtgct gaacttcacc cttgaagaag      360

tgctgttccc tcaatctgat aggttccagc cttatatgca ggaggtggtg cccttcctgg      420

ccaggctcag caacaggcta agcacatgtc atattgaagg tgatgacctg catatccaga      480

ggaatgtgca aaagctgaag gacacagtga aaaagcttgg agagagtgga gagatcaaag      540

caattggaga actggatttg ctgtttatgt ctctgagaaa tgcctgcatt tgaccagagc      600

aaagctgaaa aatgaataac taaccccctt tccctgctag aaataacaat tagatgcccc      660

aaagcgattt tttttaacca aaaggaagat gggaagccaa actccatcat gatgggtgga      720

ttccaaatga acccctgcgt tagttacaaa ggaaaccaat gccacttttg tttataagac      780

cagaaggtag actttctaag catagatatt tattgataac atttcattgt aactggtgtt      840

ctatacacag aaaacaattt attttttaaa taattgtctt tttccataaa aaagattact      900

ttccattcct ttaggggaaa aaacccctaa atagcttcat gtttccataa tcagtacttt      960

atatttataa atgtatttat tattattata agactgcatt ttatttatat cattttatta     1020

atatggattt atttatagaa acatcattcg atattgctac ttgagtgtaa ggctaatatt     1080

gatatttatg acaataatta tagagctata acatgtttat ttgacctcaa taaacacttg     1140

gatatcc                                                               1147


<210>  22
<211>  179
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(33)

<400>  22

Met Ala Ala Leu Gln Lys Ser Val Ser Ser Phe Leu Met Gly Thr Leu 
1               5                   10                  15      


Ala Thr Ser Cys Leu Leu Leu Leu Ala Leu Leu Val Gln Gly Gly Ala 
            20                  25                  30          


Ala Ala Pro Ile Ser Ser His Cys Arg Leu Asp Lys Ser Asn Phe Gln 
        35                  40                  45              


Gln Pro Tyr Ile Thr Asn Arg Thr Phe Met Leu Ala Lys Glu Ala Ser 
    50                  55                  60                  


Leu Ala Asp Asn Asn Thr Asp Val Arg Leu Ile Gly Glu Lys Leu Phe 
65                  70                  75                  80  


His Gly Val Ser Met Ser Glu Arg Cys Tyr Leu Met Lys Gln Val Leu 
                85                  90                  95      


Asn Phe Thr Leu Glu Glu Val Leu Phe Pro Gln Ser Asp Arg Phe Gln 
            100                 105                 110         


Pro Tyr Met Gln Glu Val Val Pro Phe Leu Ala Arg Leu Ser Asn Arg 
        115                 120                 125             


Leu Ser Thr Cys His Ile Glu Gly Asp Asp Leu His Ile Gln Arg Asn 
    130                 135                 140                 


Val Gln Lys Leu Lys Asp Thr Val Lys Lys Leu Gly Glu Ser Gly Glu 
145                 150                 155                 160 


Ile Lys Ala Ile Gly Glu Leu Asp Leu Leu Phe Met Ser Leu Arg Asn 
                165                 170                 175     


Ala Cys Ile 
            


<210>  23
<211>  1284
<212>  DNA
<213>  Homo sapiens

<400>  23
agatgcccca cagcactgct cttccagagg caagaccaac caagatgagt gccctgggag       60

ctgtcattgc cctcctgctc tggggacagc tttttgcagt ggactcaggc aatgatgtca      120

cggatatcgc agatgacggc tgcccgaagc cccccgagat tgcacatggc tatgtggagc      180

actcggttcg ctaccagtgt aagaactact acaaactgcg cacagaagga gatggagtgt      240

acaccttaaa caatgagaag cagtggataa ataaggctgt tggagataaa cttcctgaat      300

gtgaagcagt atgtgggaag cccaagaatc cggcaaaccc agtgcagcgg atcctgggtg      360

gacacctgga tgccaaaggc agctttccct ggcaggctaa gatggtttcc caccataatc      420

tcaccacagg tgccacgctg atcaatgaac aatggctgct gaccacggct aaaaatctct      480

tcctgaacca ttcagaaaat gcaacagcga aagacattgc ccctacttta acactctatg      540

tggggaaaaa gcagcttgta gagattgaga aggttgttct acaccctaac tactcccagg      600

tagatattgg gctcatcaaa ctcaaacaga aggtgtctgt taatgagaga gtgatgccca      660

tctgcctacc ttcaaaggat tatgcagaag tagggcgtgt gggttatgtt tctggctggg      720

ggcgaaatgc caattttaaa tttactgacc atctgaagta tgtcatgctg cctgtggctg      780

accaagacca atgcataagg cattatgaag gcagcacagt ccccgaaaag aagacaccga      840

agagccctgt aggggtgcag cccatactga atgaacacac cttctgtgct ggcatgtcta      900

agtaccaaga agacacctgc tatggcgatg cgggcagtgc ctttgccgtt cacgacctgg      960

aggaggacac ctggtatgcg actgggatct taagctttga taagagctgt gctgtggctg     1020

agtatggtgt gtatgtgaag gtgacttcca tccaggactg ggttcagaag accatagctg     1080

agaactaatg caaggctggc cggaagccct tgcctgaaag caagatttca gcctggaaga     1140

gggcaaagtg gacgggagtg gacaggagtg gatgcgataa gatgtggttt gaagctgatg     1200

ggtgccagcc ctgcattgct gagtcaatca ataaagagct ttcttttgac ccataaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaa                                            1284


<210>  24
<211>  347
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(18)

<400>  24

Met Ser Ala Leu Gly Ala Val Ile Ala Leu Leu Leu Trp Gly Gln Leu 
1               5                   10                  15      


Phe Ala Val Asp Ser Gly Asn Asp Val Thr Asp Ile Ala Asp Asp Gly 
            20                  25                  30          


Cys Pro Lys Pro Pro Glu Ile Ala His Gly Tyr Val Glu His Ser Val 
        35                  40                  45              


Arg Tyr Gln Cys Lys Asn Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly 
    50                  55                  60                  


Val Tyr Thr Leu Asn Asn Glu Lys Gln Trp Ile Asn Lys Ala Val Gly 
65                  70                  75                  80  


Asp Lys Leu Pro Glu Cys Glu Ala Val Cys Gly Lys Pro Lys Asn Pro 
                85                  90                  95      


Ala Asn Pro Val Gln Arg Ile Leu Gly Gly His Leu Asp Ala Lys Gly 
            100                 105                 110         


Ser Phe Pro Trp Gln Ala Lys Met Val Ser His His Asn Leu Thr Thr 
        115                 120                 125             


Gly Ala Thr Leu Ile Asn Glu Gln Trp Leu Leu Thr Thr Ala Lys Asn 
    130                 135                 140                 


Leu Phe Leu Asn His Ser Glu Asn Ala Thr Ala Lys Asp Ile Ala Pro 
145                 150                 155                 160 


Thr Leu Thr Leu Tyr Val Gly Lys Lys Gln Leu Val Glu Ile Glu Lys 
                165                 170                 175     


Val Val Leu His Pro Asn Tyr Ser Gln Val Asp Ile Gly Leu Ile Lys 
            180                 185                 190         


Leu Lys Gln Lys Val Ser Val Asn Glu Arg Val Met Pro Ile Cys Leu 
        195                 200                 205             


Pro Ser Lys Asp Tyr Ala Glu Val Gly Arg Val Gly Tyr Val Ser Gly 
    210                 215                 220                 


Trp Gly Arg Asn Ala Asn Phe Lys Phe Thr Asp His Leu Lys Tyr Val 
225                 230                 235                 240 


Met Leu Pro Val Ala Asp Gln Asp Gln Cys Ile Arg His Tyr Glu Gly 
                245                 250                 255     


Ser Thr Val Pro Glu Lys Lys Thr Pro Lys Ser Pro Val Gly Val Gln 
            260                 265                 270         


Pro Ile Leu Asn Glu His Thr Phe Cys Ala Gly Met Ser Lys Tyr Gln 
        275                 280                 285             


Glu Asp Thr Cys Tyr Gly Asp Ala Gly Ser Ala Phe Ala Val His Asp 
    290                 295                 300                 


Leu Glu Glu Asp Thr Trp Tyr Ala Thr Gly Ile Leu Ser Phe Asp Lys 
305                 310                 315                 320 


Ser Cys Ala Val Ala Glu Tyr Gly Val Tyr Val Lys Val Thr Ser Ile 
                325                 330                 335     


Gln Asp Trp Val Gln Lys Thr Ile Ala Glu Asn 
            340                 345         


<210>  25
<211>  1201
<212>  DNA
<213>  Homo sapiens

<400>  25
aatattagag tctcaacccc caataaatat aggactggag atgtctgagg ctcattctgc       60

cctcgagccc accgggaacg aaagagaagc tctatctccc ctccaggagc ccagctatga      120

actccttctc cacaagcgcc ttcggtccag ttgccttctc cctggggctg ctcctggtgt      180

tgcctgctgc cttccctgcc ccagtacccc caggagaaga ttccaaagat gtagccgccc      240

cacacagaca gccactcacc tcttcagaac gaattgacaa acaaattcgg tacatcctcg      300

acggcatctc agccctgaga aaggagacat gtaacaagag taacatgtgt gaaagcagca      360

aagaggcact ggcagaaaac aacctgaacc ttccaaagat ggctgaaaaa gatggatgct      420

tccaatctgg attcaatgag gagacttgcc tggtgaaaat catcactggt cttttggagt      480

ttgaggtata cctagagtac ctccagaaca gatttgagag tagtgaggaa caagccagag      540

ctgtgcagat gagtacaaaa gtcctgatcc agttcctgca gaaaaaggca aagaatctag      600

atgcaataac cacccctgac ccaaccacaa atgccagcct gctgacgaag ctgcaggcac      660

agaaccagtg gctgcaggac atgacaactc atctcattct gcgcagcttt aaggagttcc      720

tgcagtccag cctgagggct cttcggcaaa tgtagcatgg gcacctcaga ttgttgttgt      780

taatgggcat tccttcttct ggtcagaaac ctgtccactg ggcacagaac ttatgttgtt      840

ctctatggag aactaaaagt atgagcgtta ggacactatt ttaattattt ttaatttatt      900

aatatttaaa tatgtgaagc tgagttaatt tatgtaagtc atatttatat ttttaagaag      960

taccacttga aacattttat gtattagttt tgaaataata atggaaagtg gctatgcagt     1020

ttgaatatcc tttgtttcag agccagatca tttcttggaa agtgtaggct tacctcaaat     1080

aaatggctaa cttatacata tttttaaaga aatatttata ttgtatttat ataatgtata     1140

aatggttttt ataccaataa atggcatttt aaaaaattca gcaaaaaaaa aaaaaaaaaa     1200

a                                                                     1201


<210>  26
<211>  212
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(29)

<400>  26

Met Asn Ser Phe Ser Thr Ser Ala Phe Gly Pro Val Ala Phe Ser Leu 
1               5                   10                  15      


Gly Leu Leu Leu Val Leu Pro Ala Ala Phe Pro Ala Pro Val Pro Pro 
            20                  25                  30          


Gly Glu Asp Ser Lys Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr 
        35                  40                  45              


Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile 
    50                  55                  60                  


Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser 
65                  70                  75                  80  


Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala 
                85                  90                  95      


Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu 
            100                 105                 110         


Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr 
        115                 120                 125             


Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln 
    130                 135                 140                 


Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn 
145                 150                 155                 160 


Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu 
                165                 170                 175     


Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His 
            180                 185                 190         


Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala 
        195                 200                 205             


Leu Arg Gln Met 
    210         


<210>  27
<211>  1859
<212>  DNA
<213>  Homo sapiens

<400>  27
gcaggcacaa actcatccat ccccagttga ttggaagaaa caacgatgac tcctgggaag       60

acctcattgg tgtcactgct actgctgctg agcctggagg ccatagtgaa ggcaggaatc      120

acaatcccac gaaatccagg atgcccaaat tctgaggaca agaacttccc ccggactgtg      180

atggtcaacc tgaacatcca taaccggaat accaatacca atcccaaaag gtcctcagat      240

tactacaacc gatccacctc accttggaat ctccaccgca atgaggaccc tgagagatat      300

ccctctgtga tctgggaggc aaagtgccgc cacttgggct gcatcaacgc tgatgggaac      360

gtggactacc acatgaactc tgtccccatc cagcaagaga tcctggtcct gcgcagggag      420

cctccacact gccccaactc cttccggctg gagaagatac tggtgtccgt gggctgcacc      480

tgtgtcaccc cgattgtcca ccatgtggcc taagagctct ggggagccca cactccccaa      540

agcagttaga ctatggagag ccgacccagc ccctcaggaa ccctcatcct tcaaagacag      600

cctcatttcg gactaaactc attagagttc ttaaggcagt ttgtccaatt aaagcttcag      660

aggtaacact tggccaagat atgagatctg aattaccttt ccctctttcc aagaaggaag      720

gtttgactga gtaccaattt gcttcttgtt tactttttta agggctttaa gttatttatg      780

tatttaatat gccctgagat aactttgggg tataagattc cattttaatg aattacctac      840

tttattttgt ttgtcttttt aaagaagata agattctggg cttgggaatt ttattattta      900

aaaggtaaaa cctgtattta tttgagctat ttaaggatct atttatgttt aagtatttag      960

aaaaaggtga aaaagcacta ttatcagttc tgcctaggta aatgtaagat agaattaaat     1020

ggcagtgcaa aatttctgag tctttacaac atacggatat agtatttcct cctctttgtt     1080

tttaaaagtt ataacatggc tgaaaagaaa gattaaacct actttcatat gtattaattt     1140

aaattttgca atttgttgag gttttacaag agatacagca agtctaactc tctgttccat     1200

taaaccctta taataaaatc cttctgtaat aataaagttt caaaagaaaa tgtttatttg     1260

ttctcattaa atgtatttta gcaaactcag ctcttcccta ttgggaagag ttatgcaaat     1320

tctcctataa gcaaaacaaa gcatgtcttt gagtaacaat gacctggaaa tacccaaaat     1380

tccaagttct cgatttcaca tgccttcaag actgaacacc gactaaggtt ttcatactat     1440

tagccaatgc tgtagacaga agcattttga taggaataga gcaaataaga taatggccct     1500

gaggaatggc atgtcattat taaagatcat atggggaaaa tgaaaccctc cccaaaatac     1560

aagaagttct gggaggagac attgtcttca gactacaatg tccagtttct cccctagact     1620

caggcttcct ttggagatta aggcccctca gagatcaaca gaccaacatt tttctcttcc     1680

tcaagcaaca ctcctagggc ctggcttctg tctgatcaag gcaccacaca acccagaaag     1740

gagctgatgg ggcagaacga actttaagta tgagaaaagt tcagcccaag taaaataaaa     1800

actcaatcac attcaattcc agagtagttt caagtttcac atcgtaacca ttttcgccc      1859


<210>  28
<211>  155
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(23)

<400>  28

Met Thr Pro Gly Lys Thr Ser Leu Val Ser Leu Leu Leu Leu Leu Ser 
1               5                   10                  15      


Leu Glu Ala Ile Val Lys Ala Gly Ile Thr Ile Pro Arg Asn Pro Gly 
            20                  25                  30          


Cys Pro Asn Ser Glu Asp Lys Asn Phe Pro Arg Thr Val Met Val Asn 
        35                  40                  45              


Leu Asn Ile His Asn Arg Asn Thr Asn Thr Asn Pro Lys Arg Ser Ser 
    50                  55                  60                  


Asp Tyr Tyr Asn Arg Ser Thr Ser Pro Trp Asn Leu His Arg Asn Glu 
65                  70                  75                  80  


Asp Pro Glu Arg Tyr Pro Ser Val Ile Trp Glu Ala Lys Cys Arg His 
                85                  90                  95      


Leu Gly Cys Ile Asn Ala Asp Gly Asn Val Asp Tyr His Met Asn Ser 
            100                 105                 110         


Val Pro Ile Gln Gln Glu Ile Leu Val Leu Arg Arg Glu Pro Pro His 
        115                 120                 125             


Cys Pro Asn Ser Phe Arg Leu Glu Lys Ile Leu Val Ser Val Gly Cys 
    130                 135                 140                 


Thr Cys Val Thr Pro Ile Val His His Val Ala 
145                 150                 155 


<210>  29
<211>  2390
<212>  DNA
<213>  Homo sapiens

<400>  29
agagccttcg tttgccaagt cgcctccaga ccgcagacat gaaacttgtc ttcctcgtcc       60

tgctgttcct cggggccctc ggactgtgtc tggctggccg taggaggagt gttcagtggt      120

gcgccgtatc ccaacccgag gccacaaaat gcttccaatg gcaaaggaat atgagaaaag      180

tgcgtggccc tcctgtcagc tgcataaaga gagactcccc catccagtgt atccaggcca      240

ttgcggaaaa cagggccgat gctgtgaccc ttgatggtgg tttcatatac gaggcaggcc      300

tggcccccta caaactgcga cctgtagcgg cggaagtcta cgggaccgaa agacagccac      360

gaactcacta ttatgccgtg gctgtggtga agaagggcgg cagctttcag ctgaacgaac      420

tgcaaggtct gaagtcctgc cacacaggcc ttcgcaggac cgctggatgg aatgtcccta      480

tagggacact tcgtccattc ttgaattgga cgggtccacc tgagcccatt gaggcagctg      540

tggccaggtt cttctcagcc agctgtgttc ccggtgcaga taaaggacag ttccccaacc      600

tgtgtcgcct gtgtgcgggg acaggggaaa acaaatgtgc cttctcctcc caggaaccgt      660

acttcagcta ctctggtgcc ttcaagtgtc tgagagacgg ggctggagac gtggctttta      720

tcagagagag cacagtgttt gaggacctgt cagacgaggc tgaaagggac gagtatgagt      780

tactctgccc agacaacact cggaagccag tggacaagtt caaagactgc catctggccc      840

gggtcccttc tcatgccgtt gtggcacgaa gtgtgaatgg caaggaggat gccatctgga      900

atcttctccg ccaggcacag gaaaagtttg gaaaggacaa gtcaccgaaa ttccagctct      960

ttggctcccc tagtgggcag aaagatctgc tgttcaagga ctctgccatt gggttttcga     1020

gggtgccccc gaggatagat tctgggctgt accttggctc cggctacttc actgccatcc     1080

agaacttgag gaaaagtgag gaggaagtgg ctgcccggcg tgcgcgggtc gtgtggtgtg     1140

cggtgggcga gcaggagctg cgcaagtgta accagtggag tggcttgagc gaaggcagcg     1200

tgacctgctc ctcggcctcc accacagagg actgcatcgc cctggtgctg aaaggagaag     1260

ctgatgccat gagtttggat ggaggatatg tgtacactgc aggcaaatgt ggtttggtgc     1320

ctgtcctggc agagaactac aaatcccaac aaagcagtga ccctgatcct aactgtgtgg     1380

atagacctgt ggaaggatat cttgctgtgg cggtggttag gagatcagac actagcctta     1440

cctggaactc tgtgaaaggc aagaagtcct gccacaccgc cgtggacagg actgcaggct     1500

ggaatatccc catgggcctg ctcttcaacc agacgggctc ctgcaaattt gatgaatatt     1560

tcagtcaaag ctgtgcccct gggtctgacc cgagatctaa tctctgtgct ctgtgtattg     1620

gcgacgagca gggtgagaat aagtgcgtgc ccaacagcaa cgagagatac tacggctaca     1680

ctggggcttt ccggtgcctg gctgagaatg ctggagacgt tgcatttgtg aaagatgtca     1740

ctgtcttgca gaacactgat ggaaataaca atgaggcatg ggctaaggat ttgaagctgg     1800

cagactttgc gctgctgtgc ctcgatggca aacggaagcc tgtgactgag gctagaagct     1860

gccatcttgc catggccccg aatcatgccg tggtgtctcg gatggataag gtggaacgcc     1920

tgaaacaggt gttgctccac caacaggcta aatttgggag aaatggatct gactgcccgg     1980

acaagttttg cttattccag tctgaaacca aaaaccttct gttcaatgac aacactgagt     2040

gtctggccag actccatggc aaaacaacat atgaaaaata tttgggacca cagtatgtcg     2100

caggcattac taatctgaaa aagtgctcaa cctcccccct cctggaagcc tgtgaattcc     2160

tcaggaagta aaaccgaaga agatggccca gctccccaag aaagcctcag ccattcactg     2220

cccccagctc ttctccccag gtgtgttggg gccttggcct cccctgctga aggtggggat     2280

tgcccatcca tctgcttaca attccctgct gtcgtcttag caagaagtaa aatgagaaat     2340

tttgttgata ttctctcctt aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                2390


<210>  30
<211>  710
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(19)

<400>  30

Met Lys Leu Val Phe Leu Val Leu Leu Phe Leu Gly Ala Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala Gly Arg Arg Arg Ser Val Gln Trp Cys Ala Val Ser Gln 
            20                  25                  30          


Pro Glu Ala Thr Lys Cys Phe Gln Trp Gln Arg Asn Met Arg Lys Val 
        35                  40                  45              


Arg Gly Pro Pro Val Ser Cys Ile Lys Arg Asp Ser Pro Ile Gln Cys 
    50                  55                  60                  


Ile Gln Ala Ile Ala Glu Asn Arg Ala Asp Ala Val Thr Leu Asp Gly 
65                  70                  75                  80  


Gly Phe Ile Tyr Glu Ala Gly Leu Ala Pro Tyr Lys Leu Arg Pro Val 
                85                  90                  95      


Ala Ala Glu Val Tyr Gly Thr Glu Arg Gln Pro Arg Thr His Tyr Tyr 
            100                 105                 110         


Ala Val Ala Val Val Lys Lys Gly Gly Ser Phe Gln Leu Asn Glu Leu 
        115                 120                 125             


Gln Gly Leu Lys Ser Cys His Thr Gly Leu Arg Arg Thr Ala Gly Trp 
    130                 135                 140                 


Asn Val Pro Ile Gly Thr Leu Arg Pro Phe Leu Asn Trp Thr Gly Pro 
145                 150                 155                 160 


Pro Glu Pro Ile Glu Ala Ala Val Ala Arg Phe Phe Ser Ala Ser Cys 
                165                 170                 175     


Val Pro Gly Ala Asp Lys Gly Gln Phe Pro Asn Leu Cys Arg Leu Cys 
            180                 185                 190         


Ala Gly Thr Gly Glu Asn Lys Cys Ala Phe Ser Ser Gln Glu Pro Tyr 
        195                 200                 205             


Phe Ser Tyr Ser Gly Ala Phe Lys Cys Leu Arg Asp Gly Ala Gly Asp 
    210                 215                 220                 


Val Ala Phe Ile Arg Glu Ser Thr Val Phe Glu Asp Leu Ser Asp Glu 
225                 230                 235                 240 


Ala Glu Arg Asp Glu Tyr Glu Leu Leu Cys Pro Asp Asn Thr Arg Lys 
                245                 250                 255     


Pro Val Asp Lys Phe Lys Asp Cys His Leu Ala Arg Val Pro Ser His 
            260                 265                 270         


Ala Val Val Ala Arg Ser Val Asn Gly Lys Glu Asp Ala Ile Trp Asn 
        275                 280                 285             


Leu Leu Arg Gln Ala Gln Glu Lys Phe Gly Lys Asp Lys Ser Pro Lys 
    290                 295                 300                 


Phe Gln Leu Phe Gly Ser Pro Ser Gly Gln Lys Asp Leu Leu Phe Lys 
305                 310                 315                 320 


Asp Ser Ala Ile Gly Phe Ser Arg Val Pro Pro Arg Ile Asp Ser Gly 
                325                 330                 335     


Leu Tyr Leu Gly Ser Gly Tyr Phe Thr Ala Ile Gln Asn Leu Arg Lys 
            340                 345                 350         


Ser Glu Glu Glu Val Ala Ala Arg Arg Ala Arg Val Val Trp Cys Ala 
        355                 360                 365             


Val Gly Glu Gln Glu Leu Arg Lys Cys Asn Gln Trp Ser Gly Leu Ser 
    370                 375                 380                 


Glu Gly Ser Val Thr Cys Ser Ser Ala Ser Thr Thr Glu Asp Cys Ile 
385                 390                 395                 400 


Ala Leu Val Leu Lys Gly Glu Ala Asp Ala Met Ser Leu Asp Gly Gly 
                405                 410                 415     


Tyr Val Tyr Thr Ala Gly Lys Cys Gly Leu Val Pro Val Leu Ala Glu 
            420                 425                 430         


Asn Tyr Lys Ser Gln Gln Ser Ser Asp Pro Asp Pro Asn Cys Val Asp 
        435                 440                 445             


Arg Pro Val Glu Gly Tyr Leu Ala Val Ala Val Val Arg Arg Ser Asp 
    450                 455                 460                 


Thr Ser Leu Thr Trp Asn Ser Val Lys Gly Lys Lys Ser Cys His Thr 
465                 470                 475                 480 


Ala Val Asp Arg Thr Ala Gly Trp Asn Ile Pro Met Gly Leu Leu Phe 
                485                 490                 495     


Asn Gln Thr Gly Ser Cys Lys Phe Asp Glu Tyr Phe Ser Gln Ser Cys 
            500                 505                 510         


Ala Pro Gly Ser Asp Pro Arg Ser Asn Leu Cys Ala Leu Cys Ile Gly 
        515                 520                 525             


Asp Glu Gln Gly Glu Asn Lys Cys Val Pro Asn Ser Asn Glu Arg Tyr 
    530                 535                 540                 


Tyr Gly Tyr Thr Gly Ala Phe Arg Cys Leu Ala Glu Asn Ala Gly Asp 
545                 550                 555                 560 


Val Ala Phe Val Lys Asp Val Thr Val Leu Gln Asn Thr Asp Gly Asn 
                565                 570                 575     


Asn Asn Glu Ala Trp Ala Lys Asp Leu Lys Leu Ala Asp Phe Ala Leu 
            580                 585                 590         


Leu Cys Leu Asp Gly Lys Arg Lys Pro Val Thr Glu Ala Arg Ser Cys 
        595                 600                 605             


His Leu Ala Met Ala Pro Asn His Ala Val Val Ser Arg Met Asp Lys 
    610                 615                 620                 


Val Glu Arg Leu Lys Gln Val Leu Leu His Gln Gln Ala Lys Phe Gly 
625                 630                 635                 640 


Arg Asn Gly Ser Asp Cys Pro Asp Lys Phe Cys Leu Phe Gln Ser Glu 
                645                 650                 655     


Thr Lys Asn Leu Leu Phe Asn Asp Asn Thr Glu Cys Leu Ala Arg Leu 
            660                 665                 670         


His Gly Lys Thr Thr Tyr Glu Lys Tyr Leu Gly Pro Gln Tyr Val Ala 
        675                 680                 685             


Gly Ile Thr Asn Leu Lys Lys Cys Ser Thr Ser Pro Leu Leu Glu Ala 
    690                 695                 700                 


Cys Glu Phe Leu Arg Lys 
705                 710 


<210>  31
<211>  1867
<212>  DNA
<213>  Homo sapiens

<400>  31
cacatagctc agttcccata aaagggctgg tttgccgcgt cggggagtgg agtgggacag       60

gtatataaag gaagtacagg gcctggggaa gaggccctgt ctaggtagct ggcaccagga      120

gccgtgggca agggaagagg ccacaccctg ccctgctctg ctgcagccag aatgggtgtg      180

aaggcgtctc aaacaggctt tgtggtcctg gtgctgctcc agtgctgctc tgcatacaaa      240

ctggtctgct actacaccag ctggtcccag taccgggaag gcgatgggag ctgcttccca      300

gatgcccttg accgcttcct ctgtacccac atcatctaca gctttgccaa tataagcaac      360

gatcacatcg acacctggga gtggaatgat gtgacgctct acggcatgct caacacactc      420

aagaacagga accccaacct gaagactctc ttgtctgtcg gaggatggaa ctttgggtct      480

caaagatttt ccaagatagc ctccaacacc cagagtcgcc ggactttcat caagtcagta      540

ccgccatttc tgcgcaccca tggctttgat gggctggacc ttgcctggct ctaccctgga      600

cggagagaca aacagcattt taccacccta atcaaggaaa tgaaggccga atttataaag      660

gaagcccagc cagggaaaaa gcagctcctg ctcagcgcag cactgtctgc ggggaaggtc      720

accattgaca gcagctatga cattgccaag atatcccaac acctggattt cattagcatc      780

atgacctacg attttcatgg agcctggcgt gggaccacag gccatcacag tcccctgttc      840

cgaggtcagg aggatgcaag tcctgacaga ttcagcaaca ctgactatgc tgtggggtac      900

atgttgaggc tgggggctcc tgccagtaag ctggtgatgg gcatccccac cttcgggagg      960

agcttcactc tggcttcttc tgagactggt gttggagccc caatctcagg accgggaatt     1020

ccaggccggt tcaccaagga ggcagggacc cttgcctact atgagatctg tgacttcctc     1080

cgcggagcca cagtccatag aatcctcggc cagcaggtcc cctatgccac caagggcaac     1140

cagtgggtag gatacgacga ccaggaaagc gtcaaaagca aggtgcagta cctgaaggac     1200

aggcagctgg cgggcgccat ggtatgggcc ctggacctgg atgacttcca gggctccttc     1260

tgcggccagg atctgcgctt ccctctcacc aatgccatca aggatgcact cgctgcaacg     1320

tagccctctg ttctgcacac agcacggggg ccaaggatgc cccgtccccc tctggctcca     1380

gctggccggg agcctgatca cctgccctgc tgagtcccag gctgagcctc agtctccctc     1440

ccttggggcc tatgcagagg tccacaacac acagatttga gctcagccct ggtgggcaga     1500

gaggtaggga tggggctgtg gggatagtga ggcatcgcaa tgtaagactc gggattagta     1560

cacacttgtt gattaatgga aatgtttaca gatccccaag cctggcaagg gaatttcttc     1620

aactccctgc cccccagccc tccttatcaa aggacaccat tttggcaagc tctatcacca     1680

aggagccaaa catcctacaa gacacagtga ccatactaat tataccccct gcaaagccca     1740

gcttgaaacc ttcacttagg aacgtaatcg tgtcccctat cctacttccc cttcctaatt     1800

ccacagctgc tcaataaagt acaagagctt aacagtgaaa aaaaaaaaaa aaaaaaaaaa     1860

aaaaaaa                                                               1867


<210>  32
<211>  383
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(21)

<400>  32

Met Gly Val Lys Ala Ser Gln Thr Gly Phe Val Val Leu Val Leu Leu 
1               5                   10                  15      


Gln Cys Cys Ser Ala Tyr Lys Leu Val Cys Tyr Tyr Thr Ser Trp Ser 
            20                  25                  30          


Gln Tyr Arg Glu Gly Asp Gly Ser Cys Phe Pro Asp Ala Leu Asp Arg 
        35                  40                  45              


Phe Leu Cys Thr His Ile Ile Tyr Ser Phe Ala Asn Ile Ser Asn Asp 
    50                  55                  60                  


His Ile Asp Thr Trp Glu Trp Asn Asp Val Thr Leu Tyr Gly Met Leu 
65                  70                  75                  80  


Asn Thr Leu Lys Asn Arg Asn Pro Asn Leu Lys Thr Leu Leu Ser Val 
                85                  90                  95      


Gly Gly Trp Asn Phe Gly Ser Gln Arg Phe Ser Lys Ile Ala Ser Asn 
            100                 105                 110         


Thr Gln Ser Arg Arg Thr Phe Ile Lys Ser Val Pro Pro Phe Leu Arg 
        115                 120                 125             


Thr His Gly Phe Asp Gly Leu Asp Leu Ala Trp Leu Tyr Pro Gly Arg 
    130                 135                 140                 


Arg Asp Lys Gln His Phe Thr Thr Leu Ile Lys Glu Met Lys Ala Glu 
145                 150                 155                 160 


Phe Ile Lys Glu Ala Gln Pro Gly Lys Lys Gln Leu Leu Leu Ser Ala 
                165                 170                 175     


Ala Leu Ser Ala Gly Lys Val Thr Ile Asp Ser Ser Tyr Asp Ile Ala 
            180                 185                 190         


Lys Ile Ser Gln His Leu Asp Phe Ile Ser Ile Met Thr Tyr Asp Phe 
        195                 200                 205             


His Gly Ala Trp Arg Gly Thr Thr Gly His His Ser Pro Leu Phe Arg 
    210                 215                 220                 


Gly Gln Glu Asp Ala Ser Pro Asp Arg Phe Ser Asn Thr Asp Tyr Ala 
225                 230                 235                 240 


Val Gly Tyr Met Leu Arg Leu Gly Ala Pro Ala Ser Lys Leu Val Met 
                245                 250                 255     


Gly Ile Pro Thr Phe Gly Arg Ser Phe Thr Leu Ala Ser Ser Glu Thr 
            260                 265                 270         


Gly Val Gly Ala Pro Ile Ser Gly Pro Gly Ile Pro Gly Arg Phe Thr 
        275                 280                 285             


Lys Glu Ala Gly Thr Leu Ala Tyr Tyr Glu Ile Cys Asp Phe Leu Arg 
    290                 295                 300                 


Gly Ala Thr Val His Arg Ile Leu Gly Gln Gln Val Pro Tyr Ala Thr 
305                 310                 315                 320 


Lys Gly Asn Gln Trp Val Gly Tyr Asp Asp Gln Glu Ser Val Lys Ser 
                325                 330                 335     


Lys Val Gln Tyr Leu Lys Asp Arg Gln Leu Ala Gly Ala Met Val Trp 
            340                 345                 350         


Ala Leu Asp Leu Asp Asp Phe Gln Gly Ser Phe Cys Gly Gln Asp Leu 
        355                 360                 365             


Arg Phe Pro Leu Thr Asn Ala Ile Lys Asp Ala Leu Ala Ala Thr 
    370                 375                 380             


<210>  33
<211>  1024
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (207)..(207)
<223>  n = A; TGA codes for selenocysteine

<400>  33
cttcctggct cctccttcct ccccacccct ctaataggct cataagtggg ctcaggcctc       60

tctgcggggc tcactctgcg cttcaccatg gctttcattg ccaagtcctt ctatgacctc      120

agtgccatca gcctggatgg ggagaaggta gatttcaata cgttccgggg cagggccgtg      180

ctgattgaga atgtggcttc gctctgnggc acaaccaccc gggacttcac ccagctcaac      240

gagctgcaat gccgctttcc caggcgcctg gtggtccttg gcttcccttg caaccaattt      300

ggacatcagg agaactgtca gaatgaggag atcctgaaca gtctcaagta tgtccgtcct      360

gggggtggat accagcccac cttcaccctt gtccaaaaat gtgaggtgaa tgggcagaac      420

gagcatcctg tcttcgccta cctgaaggac aagctcccct acccttatga tgacccattt      480

tccctcatga ccgatcccaa gctcatcatt tggagccctg tgcgccgctc agatgtggcc      540

tggaactttg agaagttcct catagggccg gagggagagc ccttccgacg ctacagccgc      600

accttcccaa ccatcaacat tgagcctgac atcaagcgcc tccttaaagt tgccatatag      660

atgtgaactg ctcaacacac agatctccta ctccatccag tcctgaggag ccttaggatg      720

cagcatgcct tcaggagaca ctgctggacc tcagcattcc cttgatatca gtccccttca      780

ctgcagagcc ttgcctttcc cctctgcctg tttccttttc ctctcccaac cctctggttg      840

gtgattcaac ttgggctcca agacttgggt aagctctggg ccttcacaga atgatggcac      900

cttcctaaac cctcatgggt ggtgtctgag aggcgtgaag ggcctggagc cactctgcta      960

gaagagacca ataaagggca ggtgtggaaa cggcaaaaaa aaaaaaaaaa aaaaaaaaaa     1020

aaaa                                                                  1024


<210>  34
<211>  190
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = selenocytseine

<400>  34

Met Ala Phe Ile Ala Lys Ser Phe Tyr Asp Leu Ser Ala Ile Ser Leu 
1               5                   10                  15      


Asp Gly Glu Lys Val Asp Phe Asn Thr Phe Arg Gly Arg Ala Val Leu 
            20                  25                  30          


Ile Glu Asn Val Ala Ser Leu Xaa Gly Thr Thr Thr Arg Asp Phe Thr 
        35                  40                  45              


Gln Leu Asn Glu Leu Gln Cys Arg Phe Pro Arg Arg Leu Val Val Leu 
    50                  55                  60                  


Gly Phe Pro Cys Asn Gln Phe Gly His Gln Glu Asn Cys Gln Asn Glu 
65                  70                  75                  80  


Glu Ile Leu Asn Ser Leu Lys Tyr Val Arg Pro Gly Gly Gly Tyr Gln 
                85                  90                  95      


Pro Thr Phe Thr Leu Val Gln Lys Cys Glu Val Asn Gly Gln Asn Glu 
            100                 105                 110         


His Pro Val Phe Ala Tyr Leu Lys Asp Lys Leu Pro Tyr Pro Tyr Asp 
        115                 120                 125             


Asp Pro Phe Ser Leu Met Thr Asp Pro Lys Leu Ile Ile Trp Ser Pro 
    130                 135                 140                 


Val Arg Arg Ser Asp Val Ala Trp Asn Phe Glu Lys Phe Leu Ile Gly 
145                 150                 155                 160 


Pro Glu Gly Glu Pro Phe Arg Arg Tyr Ser Arg Thr Phe Pro Thr Ile 
                165                 170                 175     


Asn Ile Glu Pro Asp Ile Lys Arg Leu Leu Lys Val Ala Ile 
            180                 185                 190 


<210>  35
<211>  1779
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (436)..(436)
<223>  n = A; TGA codes for selenocysteine

<400>  35
gtcgccccgg gacggggagg tggggagctg agggcaagtc gcgcccgccc ctgaaatccc       60

agccgcctag cgattggctg caagggtctc ggcttggccg cggattggtc acacccgagg      120

gcttgaaagg tggctgggag cgccggacac ctcagacgga cggtggccag ggatcaggca      180

gcggctcagg cgaccctgag tgtgccccca ccccgccatg gcccggctgc tgcaggcgtc      240

ctgcctgctt tccctgctcc tggccggctt cgtctcgcag agccggggac aagagaagtc      300

gaagatggac tgccatggtg gcataagtgg caccatttac gagtacggag ccctcaccat      360

tgatggggag gagtacatcc ccttcaagca gtatgctggc aaatacgtcc tctttgtcaa      420

cgtggccagc tactgnggcc tgacgggcca gtacattgaa ctgaatgcac tacaggaaga      480

gcttgcacca ttcggtctgg tcattctggg ctttccctgc aaccaatttg gaaaacagga      540

accaggagag aactcagaga tccttcctac cctcaagtat gtccgaccag gtggaggctt      600

tgtccctaat ttccagctct ttgagaaagg ggatgtcaat ggagagaaag agcagaaatt      660

ctacactttc ctaaagaact cctgtcctcc cacctcggag ctcctgggta catctgaccg      720

cctcttctgg gaacccatga aggttcacga catccgctgg aactttgaga agttcctggt      780

ggggccagat ggtataccca tcatgcgctg gcaccaccgg accacggtca gcaacgtcaa      840

gatggacatc ctgtcctaca tgaggcggca ggcagccctg ggggtcaaga ggaagtaact      900

gaaggccgtc tcatcccatg tccaccatgt aggggaggga ctttgttcag gaagaaatcc      960

gtgtctccaa ccacactatc tacccatcac agaccccttt cctatcactc aaggccccag     1020

cctggcacaa atggatgcat acagttctgt gtactgccag gcatgtgggt gtgggtgcat     1080

gtgggtgttt acacacatgc ctacaggtat gcgtgattgt gtgtgtgtgc atgggtgtac     1140

agccacgtgt ctacctatgt gtctttctgg gaatgtgtac catctgtgtg cctgcagctg     1200

tgtagtgctg gacagtgaca accctttctc tccagttctc cactccaatg ataatagttc     1260

acttacacct aaacccaaag gaaaaaccag ctctaggtcc aattgttctg ctctaactga     1320

tacctcaacc ttggggccag catctcccac tgcctccaaa tattagtaac tatgactgac     1380

gtccccagaa gtttctgggt ctaccacact ccccaacccc ccactcctac ttcctgaagg     1440

gccctcccaa ggctacatcc ccaccccaca gttctccctg agagagatca acctccctga     1500

gatcaaccaa ggcagatgtg acagcaaggg ccacggaccc catggcaggg gtggcgtctt     1560

catgagggag gggcccaaag cccttgtggg cggacctccc ctgagcctgt ctgaggggcc     1620

agcccttagt gcattcaggc taaggcccct gggcagggat gccacccctg ctccttcgga     1680

ggacgtgccc tcacccctca ctggtccact ggcttgagac tcaccccgtc tgcccagtaa     1740

aagcctttct gcagcagctg aaaaaaaaaa aaaaaaaaa                            1779


<210>  36
<211>  226
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (73)..(73)
<223>  Xaa = selenocysteine

<400>  36

Met Ala Arg Leu Leu Gln Ala Ser Cys Leu Leu Ser Leu Leu Leu Ala 
1               5                   10                  15      


Gly Phe Val Ser Gln Ser Arg Gly Gln Glu Lys Ser Lys Met Asp Cys 
            20                  25                  30          


His Gly Gly Ile Ser Gly Thr Ile Tyr Glu Tyr Gly Ala Leu Thr Ile 
        35                  40                  45              


Asp Gly Glu Glu Tyr Ile Pro Phe Lys Gln Tyr Ala Gly Lys Tyr Val 
    50                  55                  60                  


Leu Phe Val Asn Val Ala Ser Tyr Xaa Gly Leu Thr Gly Gln Tyr Ile 
65                  70                  75                  80  


Glu Leu Asn Ala Leu Gln Glu Glu Leu Ala Pro Phe Gly Leu Val Ile 
                85                  90                  95      


Leu Gly Phe Pro Cys Asn Gln Phe Gly Lys Gln Glu Pro Gly Glu Asn 
            100                 105                 110         


Ser Glu Ile Leu Pro Thr Leu Lys Tyr Val Arg Pro Gly Gly Gly Phe 
        115                 120                 125             


Val Pro Asn Phe Gln Leu Phe Glu Lys Gly Asp Val Asn Gly Glu Lys 
    130                 135                 140                 


Glu Gln Lys Phe Tyr Thr Phe Leu Lys Asn Ser Cys Pro Pro Thr Ser 
145                 150                 155                 160 


Glu Leu Leu Gly Thr Ser Asp Arg Leu Phe Trp Glu Pro Met Lys Val 
                165                 170                 175     


His Asp Ile Arg Trp Asn Phe Glu Lys Phe Leu Val Gly Pro Asp Gly 
            180                 185                 190         


Ile Pro Ile Met Arg Trp His His Arg Thr Thr Val Ser Asn Val Lys 
        195                 200                 205             


Met Asp Ile Leu Ser Tyr Met Arg Arg Gln Ala Ala Leu Gly Val Lys 
    210                 215                 220                 


Arg Lys 
225     


<210>  37
<211>  938
<212>  DNA
<213>  Homo sapiens

<400>  37
gcacggaggg gcagagaccc cggagcccca gccccaccat gaccctcggc cgccgactcg       60

cgtgtctttt cctcgcctgt gtcctgccgg ccttgctgct ggggggcacc gcgctggcct      120

cggagattgt ggggggccgg cgagcgcggc cccacgcgtg gcccttcatg gtgtccctgc      180

agctgcgcgg aggccacttc tgcggcgcca ccctgattgc gcccaacttc gtcatgtcgg      240

ccgcgcactg cgtggcgaat gtaaacgtcc gcgcggtgcg ggtggtcctg ggagcccata      300

acctctcgcg gcgggagccc acccggcagg tgttcgccgt gcagcgcatc ttcgaaaacg      360

gctacgaccc cgtaaacttg ctcaacgaca tcgtgattct ccagctcaac gggtcggcca      420

ccatcaacgc caacgtgcag gtggcccagc tgccggctca gggacgccgc ctgggcaacg      480

gggtgcagtg cctggccatg ggctggggcc ttctgggcag gaaccgtggg atcgccagcg      540

tcctgcagga gctcaacgtg acggtggtga cgtccctctg ccgtcgcagc aacgtctgca      600

ctctcgtgag gggccggcag gccggcgtct gtttcgggga ctccggcagc cccttggtct      660

gcaacgggct aatccacgga attgcctcct tcgtccgggg aggctgcgcc tcagggctct      720

accccgatgc ctttgccccg gtggcacagt ttgtaaactg gatcgactct atcatccaac      780

gctccgagga caacccctgt ccccaccccc gggacccgga cccggccagc aggacccact      840

gagaagggct gcccgggtca cctcagctgc ccacacccac actctccagc atctggcaca      900

ataaacattc tctgttttgt agaaaaaaaa aaaaaaaa                              938


<210>  38
<211>  267
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(29)

<400>  38

Met Thr Leu Gly Arg Arg Leu Ala Cys Leu Phe Leu Ala Cys Val Leu 
1               5                   10                  15      


Pro Ala Leu Leu Leu Gly Gly Thr Ala Leu Ala Ser Glu Ile Val Gly 
            20                  25                  30          


Gly Arg Arg Ala Arg Pro His Ala Trp Pro Phe Met Val Ser Leu Gln 
        35                  40                  45              


Leu Arg Gly Gly His Phe Cys Gly Ala Thr Leu Ile Ala Pro Asn Phe 
    50                  55                  60                  


Val Met Ser Ala Ala His Cys Val Ala Asn Val Asn Val Arg Ala Val 
65                  70                  75                  80  


Arg Val Val Leu Gly Ala His Asn Leu Ser Arg Arg Glu Pro Thr Arg 
                85                  90                  95      


Gln Val Phe Ala Val Gln Arg Ile Phe Glu Asn Gly Tyr Asp Pro Val 
            100                 105                 110         


Asn Leu Leu Asn Asp Ile Val Ile Leu Gln Leu Asn Gly Ser Ala Thr 
        115                 120                 125             


Ile Asn Ala Asn Val Gln Val Ala Gln Leu Pro Ala Gln Gly Arg Arg 
    130                 135                 140                 


Leu Gly Asn Gly Val Gln Cys Leu Ala Met Gly Trp Gly Leu Leu Gly 
145                 150                 155                 160 


Arg Asn Arg Gly Ile Ala Ser Val Leu Gln Glu Leu Asn Val Thr Val 
                165                 170                 175     


Val Thr Ser Leu Cys Arg Arg Ser Asn Val Cys Thr Leu Val Arg Gly 
            180                 185                 190         


Arg Gln Ala Gly Val Cys Phe Gly Asp Ser Gly Ser Pro Leu Val Cys 
        195                 200                 205             


Asn Gly Leu Ile His Gly Ile Ala Ser Phe Val Arg Gly Gly Cys Ala 
    210                 215                 220                 


Ser Gly Leu Tyr Pro Asp Ala Phe Ala Pro Val Ala Gln Phe Val Asn 
225                 230                 235                 240 


Trp Ile Asp Ser Ile Ile Gln Arg Ser Glu Asp Asn Pro Cys Pro His 
                245                 250                 255     


Pro Arg Asp Pro Asp Pro Ala Ser Arg Thr His 
            260                 265         


<210>  39
<211>  1669
<212>  DNA
<213>  Homo sapiens

<400>  39
ctccctcagc aaggacagca gaggaccagc taagagggag agaagcaact acagaccccc       60

cctgaaaaca accctcagac gccacatccc ctgacaagct gccaggcagg ttctcttcct      120

ctcacatact gacccacggc tccaccctct ctcccctgga aaggacacca tgagcactga      180

aagcatgatc cgggacgtgg agctggccga ggaggcgctc cccaagaaga caggggggcc      240

ccagggctcc aggcggtgct tgttcctcag cctcttctcc ttcctgatcg tggcaggcgc      300

caccacgctc ttctgcctgc tgcactttgg agtgatcggc ccccagaggg aagagttccc      360

cagggacctc tctctaatca gccctctggc ccaggcagtc agatcatctt ctcgaacccc      420

gagtgacaag cctgtagccc atgttgtagc aaaccctcaa gctgaggggc agctccagtg      480

gctgaaccgc cgggccaatg ccctcctggc caatggcgtg gagctgagag ataaccagct      540

ggtggtgcca tcagagggcc tgtacctcat ctactcccag gtcctcttca agggccaagg      600

ctgcccctcc acccatgtgc tcctcaccca caccatcagc cgcatcgccg tctcctacca      660

gaccaaggtc aacctcctct ctgccatcaa gagcccctgc cagagggaga ccccagaggg      720

ggctgaggcc aagccctggt atgagcccat ctatctggga ggggtcttcc agctggagaa      780

gggtgaccga ctcagcgctg agatcaatcg gcccgactat ctcgactttg ccgagtctgg      840

gcaggtctac tttgggatca ttgccctgtg aggaggacga acatccaacc ttcccaaacg      900

cctcccctgc cccaatccct ttattacccc ctccttcaga caccctcaac ctcttctggc      960

tcaaaaagag aattgggggc ttagggtcgg aacccaagct tagaacttta agcaacaaga     1020

ccaccacttc gaaacctggg attcaggaat gtgtggcctg cacagtgaag tgctggcaac     1080

cactaagaat tcaaactggg gcctccagaa ctcactgggg cctacagctt tgatccctga     1140

catctggaat ctggagacca gggagccttt ggttctggcc agaatgctgc aggacttgag     1200

aagacctcac ctagaaattg acacaagtgg accttaggcc ttcctctctc cagatgtttc     1260

cagacttcct tgagacacgg agcccagccc tccccatgga gccagctccc tctatttatg     1320

tttgcacttg tgattattta ttatttattt attatttatt tatttacaga tgaatgtatt     1380

tatttgggag accggggtat cctgggggac ccaatgtagg agctgccttg gctcagacat     1440

gttttccgtg aaaacggagc tgaacaatag gctgttccca tgtagccccc tggcctctgt     1500

gccttctttt gattatgttt tttaaaatat ttatctgatt aagttgtcta aacaatgctg     1560

atttggtgac caactgtcac tcattgctga gcctctgctc cccaggggag ttgtgtctgt     1620

aatcgcccta ctattcagtg gcgagaaata aagtttgctt agaaaagaa                 1669


<210>  40
<211>  233
<212>  PRT
<213>  Homo sapiens


<220>
<221>  mat_peptide
<222>  (77)..(233)

<400>  40

Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
    -75                 -70                 -65                 


Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 
-60                 -55                 -50                 -45 


Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe 
                -40                 -35                 -30     


Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro 
            -25                 -20                 -15         


Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser 
        -10                 -5              -1  1               


Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 
5                   10                  15                  20  


Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 
                25                  30                  35      


Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 
            40                  45                  50          


Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
        55                  60                  65              


Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 
    70                  75                  80                  


Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 
85                  90                  95                  100 


Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
                105                 110                 115     


Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 
            120                 125                 130         


Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 
        135                 140                 145             


Gln Val Tyr Phe Gly Ile Ile Ala Leu 
    150                 155         


<210>  41
<211>  2024
<212>  DNA
<213>  Homo sapiens

<400>  41
aaggcaagag atctaggact tctagcccct gaactttcag ccgaatacat cttttccaaa       60

ggagtgaatt caggcccttg tatcactggc agcaggacgt gaccatggag aagctgttgt      120

gtttcttggt cttgaccagc ctctctcatg cttttggcca gacagacatg tcgaggaagg      180

cttttgtgtt tcccaaagag tcggatactt cctatgtatc cctcaaagca ccgttaacga      240

agcctctcaa agccttcact gtgtgcctcc acttctacac ggaactgtcc tcgacccgtg      300

ggtacagtat tttctcgtat gccaccaaga gacaagacaa tgagattctc atattttggt      360

ctaaggatat aggatacagt tttacagtgg gtgggtctga aatattattc gaggttcctg      420

aagtcacagt agctccagta cacatttgta caagctggga gtccgcctca gggatcgtgg      480

agttctgggt agatgggaag cccagggtga ggaagagtct gaagaaggga tacactgtgg      540

gggcagaagc aagcatcatc ttggggcagg agcaggattc cttcggtggg aactttgaag      600

gaagccagtc cctggtggga gacattggaa atgtgaacat gtgggacttt gtgctgtcac      660

cagatgagat taacaccatc tatcttggcg ggcccttcag tcctaatgtc ctgaactggc      720

gggcactgaa gtatgaagtg caaggcgaag tgttcaccaa accccagctg tggccctgag      780

gcccagctgt gggtcctgaa ggtacctccc ggttttttac accgcatggg ccccacgtct      840

ctgtctctgg tacctcccgc ttttttacac tgcatggttc ccacgtctct gtctctgggc      900

ctttgttccc ctatatgcat tgcaggcctg ctccaccctc ctcagcgcct gagaatggag      960

gtaaagtgtc tggtctggga gctcgttaac tatgctggga aacggtccaa aagaatcaga     1020

atttgaggtg ttttgttttc atttttattt caagttggac agatcttgga gataatttct     1080

tacctcacat agatgagaaa actaacaccc agaaaggaga aatgatgtta taaaaaactc     1140

ataaggcaag agctgagaag gaagcgctga tcttctattt aattccccac ccatgacccc     1200

cagaaagcag gagggcattg cccacattca cagggctctt cagtctcaga atcaggacac     1260

tggccaggtg tctggtttgg gtccagagtg ctcatcatca tgtcatagaa ctgctgggcc     1320

caggtctcct gaaatgggaa gcccagcaat accacgcagt ccctccactt tctcaaagca     1380

cactggaaag gccattagaa ttgccccagc agagcagatc tgcttttttt ccagagcaaa     1440

atgaagcact aggtataaat atgttgttac tgccaagaac ttaaatgact ggtttttgtt     1500

tgcttgcagt gctttcttaa ttttatggct cttctgggaa actcctcccc ttttccacac     1560

gaaccttgtg gggctgtgaa ttctttcttc atccccgcat tcccaatata cccaggccac     1620

aagagtggac gtgaaccaca gggtgtcctg tcagaggagc ccatctccca tctccccagc     1680

tccctatctg gaggatagtt ggatagttac gtgttcctag caggaccaac tacagtcttc     1740

ccaaggattg agttatggac tttgggagtg agacatcttc ttgctgctgg atttccaagc     1800

tgagaggacg tgaacctggg accaccagta gccatcttgt ttgccacatg gagagagact     1860

gtgaggacag aagccaaact ggaagtggag gagccaaggg attgacaaac aacagagcct     1920

tgaccacgtg gagtctctga atcagccttg tctggaacca gatctacacc tggactgccc     1980

aggtctataa gccaataaag cccctgttta cttgaaaaaa aaaa                      2024


<210>  42
<211>  224
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(18)

<400>  42

Met Glu Lys Leu Leu Cys Phe Leu Val Leu Thr Ser Leu Ser His Ala 
1               5                   10                  15      


Phe Gly Gln Thr Asp Met Ser Arg Lys Ala Phe Val Phe Pro Lys Glu 
            20                  25                  30          


Ser Asp Thr Ser Tyr Val Ser Leu Lys Ala Pro Leu Thr Lys Pro Leu 
        35                  40                  45              


Lys Ala Phe Thr Val Cys Leu His Phe Tyr Thr Glu Leu Ser Ser Thr 
    50                  55                  60                  


Arg Gly Tyr Ser Ile Phe Ser Tyr Ala Thr Lys Arg Gln Asp Asn Glu 
65                  70                  75                  80  


Ile Leu Ile Phe Trp Ser Lys Asp Ile Gly Tyr Ser Phe Thr Val Gly 
                85                  90                  95      


Gly Ser Glu Ile Leu Phe Glu Val Pro Glu Val Thr Val Ala Pro Val 
            100                 105                 110         


His Ile Cys Thr Ser Trp Glu Ser Ala Ser Gly Ile Val Glu Phe Trp 
        115                 120                 125             


Val Asp Gly Lys Pro Arg Val Arg Lys Ser Leu Lys Lys Gly Tyr Thr 
    130                 135                 140                 


Val Gly Ala Glu Ala Ser Ile Ile Leu Gly Gln Glu Gln Asp Ser Phe 
145                 150                 155                 160 


Gly Gly Asn Phe Glu Gly Ser Gln Ser Leu Val Gly Asp Ile Gly Asn 
                165                 170                 175     


Val Asn Met Trp Asp Phe Val Leu Ser Pro Asp Glu Ile Asn Thr Ile 
            180                 185                 190         


Tyr Leu Gly Gly Pro Phe Ser Pro Asn Val Leu Asn Trp Arg Ala Leu 
        195                 200                 205             


Lys Tyr Glu Val Gln Gly Glu Val Phe Thr Lys Pro Gln Leu Trp Pro 
    210                 215                 220                 


