                         SEQUENCE LISTING

<110>  Molecular Partners AG
       Binz, Hans Kaspar
       Forrer, Patrik
       Stumpp, Michael Tobias
 
<120>  Binding Proteins inhibiting the VEGF-A receptor interaction

<130>  P368A

<150>  EP08168166.0
<151>  2008-11-03

<160>  41    

<170>  PatentIn version 3.5

<210>  1
<211>  33
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat sequence motif


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa can be any naturally occurring amino acid

<400>  1

Xaa Asp Xaa Xaa Gly Xaa Thr Pro Leu His Leu Ala Ala Xaa Xaa Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  2
<211>  33
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat sequence motif


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa can be any naturally occurring amino acid

<400>  2

Xaa Asp Xaa Xaa Gly Trp Thr Pro Leu His Leu Ala Ala Xaa Xaa Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  3
<211>  33
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat sequence motif


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  Xaa can be any naturally occurring amino acid

<400>  3

Xaa Asp Xaa Xaa Gly Xaa Thr Pro Leu His Leu Ala Ala Xaa Xaa Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp Val Asn 
            20                  25                  30          


Xaa 
    


<210>  4
<211>  33
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat sequence motif


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  Xaa can be any naturally occurring amino acid

<400>  4

Xaa Asp Xaa Xaa Gly Trp Thr Pro Leu His Leu Xaa Ala Asp Leu Gly 
1               5                   10                  15      


Xaa Leu Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp Val Asn 
            20                  25                  30          


Xaa 
    


<210>  5
<211>  33
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat sequence motif


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa can be any naturally occurring amino acid

<400>  5

Xaa Asp Xaa Xaa Gly Xaa Thr Pro Leu His Leu Ala Ala Xaa Xaa Gly 
1               5                   10                  15      


His Xaa Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  6
<211>  33
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat sequence motif


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa can be any naturally occurring amino acid

<400>  6

Xaa Asp Xaa Xaa Gly Xaa Thr Pro Leu His Leu Ala Ala Xaa Xaa Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  7
<211>  33
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat sequence motif


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa can be any naturally occurring amino acid

<400>  7

Xaa Asp Xaa Xaa Gly Trp Thr Pro Leu His Leu Ala Ala Xaa Xaa Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  8
<211>  33
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat sequence motif


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  Xaa can be any naturally occurring amino acid

<400>  8

Xaa Asp Xaa Xaa Gly Xaa Thr Pro Leu His Leu Ala Ala Xaa Xaa Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp Val Asn 
            20                  25                  30          


Xaa 
    


<210>  9
<211>  33
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat sequence motif


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa can be any naturally occurring amino acid

<400>  9

Xaa Asp Xaa Xaa Gly Xaa Thr Pro Leu His Leu Xaa Ala Xaa Xaa Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  10
<211>  33
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat sequence motif


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa can be any naturally occurring amino acid

<400>  10

Xaa Asp Phe Lys Xaa Asp Thr Pro Leu His Leu Ala Ala Xaa Xaa Gly 
1               5                   10                  15      


His Xaa Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  11
<211>  33
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat sequence motif


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa can be any naturally occurring amino acid

<400>  11

Xaa Asp Xaa Leu Xaa Xaa Thr Pro Leu His Leu Ala Xaa Xaa Xaa Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  12
<211>  33
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat sequence motif


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa can be any naturally occurring amino acid

<400>  12

Xaa Asp Xaa Xaa Gly Xaa Thr Pro Leu Xaa Leu Ala Ala Xaa Xaa Gly 
1               5                   10                  15      


His Leu Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  13
<211>  33
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat sequence motif


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa can be any naturally occurring amino acid

<400>  13

Xaa Asp Xaa Xaa Gly Trp Thr Xaa Leu His Leu Ala Ala Asp Leu Gly 
1               5                   10                  15      


Xaa Leu Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp Val Asn 
            20                  25                  30          


Ala 
    


<210>  14
<211>  159
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat domain

<400>  14

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Phe Asp Trp Met Gly Trp Thr Pro Leu His Leu Ala Ala His Glu Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Thr Asp Val Ser Gly Tyr Thr Pro Leu His Leu Ala Ala Ala Asp 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val 
                85                  90                  95      


Asn Thr Lys Asp Asn Thr Gly Trp Thr Pro Leu His Leu Ser Ala Asp 
            100                 105                 110         


Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
145                 150                 155                 


<210>  15
<211>  159
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat domain

<400>  15

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Val Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Phe Asp Trp Met Gly Trp Thr Pro Leu His Leu Ala Ala His Glu Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Thr Asp Val Ser Gly Tyr Thr Pro Leu His Leu Ala Ala Ala Asp 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val 
                85                  90                  95      


Asn Thr Lys Asp Asn Thr Gly Trp Thr Pro Leu His Leu Ser Ala Asp 
            100                 105                 110         


Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
145                 150                 155                 


<210>  16
<211>  159
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat domain

<400>  16

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Phe Asp Trp Met Gly Trp Thr Pro Leu His Leu Ala Ala His Glu Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Thr Asp Val Ser Gly Tyr Thr Pro Leu His Leu Ala Ala Ala Asp 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val 
                85                  90                  95      


Asn Thr Lys Asp Asn Thr Gly Trp Thr Pro Leu His Leu Ser Ala Asp 
            100                 105                 110         


Leu Gly Arg Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
145                 150                 155                 


<210>  17
<211>  159
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat domain

<400>  17

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Phe Asp Trp Met Gly Trp Thr Pro Leu His Leu Ala Ala His Glu Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Thr Asp Val Asn 
    50                  55                  60                  


Ala Thr Asp Val Ser Gly Tyr Thr Pro Leu His Leu Ala Ala Ala Asp 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val 
                85                  90                  95      


Asn Thr Lys Asp Asn Thr Gly Trp Thr Pro Leu His Leu Ser Ala Asp 
            100                 105                 110         


Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
145                 150                 155                 


<210>  18
<211>  159
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat domain

<400>  18

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Phe Asp Trp Met Gly Trp Thr Pro Leu His Leu Ala Ala His Glu Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Thr Asp Val Ser Gly Tyr Thr Pro Leu His Leu Ala Ala Ala Asp 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val 
                85                  90                  95      


Asn Thr Lys Asp Asn Thr Gly Trp Thr Pro Leu His Leu Ser Ala Asp 
            100                 105                 110         


Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
145                 150                 155                 


<210>  19
<211>  159
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat domain

<400>  19

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Phe Asp Trp Met Gly Trp Thr Pro Leu His Leu Ala Ala His Glu Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Thr Asp Val Ser Gly Tyr Thr Pro Leu His Leu Ala Ala Ala Asp 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val 
                85                  90                  95      


Asn Thr Lys Asp Asn Thr Gly Trp Thr Pro Leu His Leu Ser Ala Asp 
            100                 105                 110         


Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp 
        115                 120                 125             


Ile Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
145                 150                 155                 


<210>  20
<211>  159
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat domain

<400>  20

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Phe Asp Trp Met Gly Trp Thr Pro Leu His Leu Ala Ala His Glu Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Thr Asp Val Ser Gly Tyr Thr Pro Leu His Leu Ala Ala Ala Asp 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val 
                85                  90                  95      


Asn Thr Thr Asp Asn Thr Gly Trp Thr Pro Leu His Leu Ser Ala Asp 
            100                 105                 110         


Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
145                 150                 155                 


<210>  21
<211>  159
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat domain

<400>  21

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Phe Asp Tyr Met Gly Trp Thr Pro Leu His Leu Ala Ala His Asn Gly 
        35                  40                  45              


His Met Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Ser Asp Tyr Ser Gly Tyr Thr Pro Leu His Leu Ala Ala Ala Asp 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val 
                85                  90                  95      


Asn Thr Lys Asp Asn Thr Gly Trp Thr Pro Leu His Leu Ser Ala Asp 
            100                 105                 110         


Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
145                 150                 155                 


<210>  22
<211>  159
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat domain

<400>  22

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Val Asp Tyr Ile Gly Trp Thr Pro Leu His Leu Ala Ala Ala Tyr Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Ser Ala Asp Val Asn 
    50                  55                  60                  


Ala Glu Asp Phe Ala Gly Tyr Thr Pro Leu His Leu Ala Ala Ser Asn 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val 
                85                  90                  95      


Asn Thr Lys Asp Asn Thr Gly Trp Thr Pro Leu His Leu Ser Ala Asp 
            100                 105                 110         


Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp 
        115                 120                 125             


Val Asn Thr Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
145                 150                 155                 


<210>  23
<211>  159
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat domain

<400>  23

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Thr Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Thr Asp Tyr Met Gly Trp Thr Pro Leu His Leu Ala Ala Lys Val Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Glu Asp Tyr Asn Gly Tyr Thr Pro Leu His Leu Ala Ala Ala Met 
65                  70                  75                  80  


Gly His Leu Glu Ile Ala Glu Val Leu Leu Lys Tyr Gly Ala Asp Val 
                85                  90                  95      


Asn Thr Lys Asp Asn Thr Gly Trp Thr Pro Leu His Leu Ser Ala Asp 
            100                 105                 110         


Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
145                 150                 155                 


<210>  24
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat domain

<400>  24

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Arg Asp Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro Trp Gly 
        35                  40                  45              


His Pro Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Ala Asp Phe Gln Gly Trp Thr Pro Leu His Leu Ala Ala Ala Val 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp 
            100                 105                 110         


Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
        115                 120                 125     


<210>  25
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat domain

<400>  25

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Arg Asp Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro Trp Gly 
        35                  40                  45              


His Pro Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Ala Asp Phe Gln Gly Trp Thr Pro Leu His Leu Ala Ala Ala Val 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp 
            100                 105                 110         


Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
        115                 120                 125     


<210>  26
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat domain

<400>  26

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Thr 
            20                  25                  30          


Ala Asp Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro Trp Gly 
        35                  40                  45              


His Pro Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala His Asp Tyr Gln Gly Trp Thr Pro Leu His Leu Ala Ala Thr Leu 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp 
            100                 105                 110         


Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
        115                 120                 125     


<210>  27
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat domain

<400>  27

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Thr 
            20                  25                  30          


Ala Asp Ser Thr Gly Trp Thr Pro Leu His Leu Val Ala Pro Trp Gly 
        35                  40                  45              


His Pro Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
    50                  55                  60                  


Thr His Asp Tyr Gln Gly Trp Thr Pro Leu His Leu Ala Ala Thr Leu 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Arg Tyr Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp 
            100                 105                 110         


Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
        115                 120                 125     


<210>  28
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat domain

<400>  28

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Thr 
            20                  25                  30          


Ala Asp Ser Thr Gly Trp Thr Pro Met His Leu Ala Ala Pro Trp Gly 
        35                  40                  45              


His Pro Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Gln Asp Phe Gln Gly Trp Thr Pro Leu His Leu Ala Ala Ala Ile 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp 
            100                 105                 110         


Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
        115                 120                 125     


<210>  29
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat domain

<400>  29

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Thr 
            20                  25                  30          


Ala Asp Ser Thr Gly Trp Thr Pro Leu His Leu Ala Val Pro Trp Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Lys Asp Phe Gln Gly Trp Thr Pro Leu His Leu Ala Ala Ala Ile 
65                  70                  75                  80  


Gly His Gln Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp 
            100                 105                 110         


Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
        115                 120                 125     


<210>  30
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat domain

<400>  30

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Val Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asp Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Ser Asp Phe Lys Gly Asp Thr Pro Leu His Leu Ala Ala Ser Gln Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Tyr Asp Met Leu Gly Trp Thr Pro Leu His Leu Ala Ala Asp Leu 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Gln Asp Arg Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp 
            100                 105                 110         


Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
        115                 120                 125     


<210>  31
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat domain

<400>  31

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Val Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Ser Asp Phe Lys Gly Asp Thr Pro Leu His Leu Ala Ala Ser Gln Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Ser Ala Asp Val Asn 
    50                  55                  60                  


Ala Phe Asp Leu Leu Gly Trp Thr Pro Leu His Leu Ala Ala Asp Leu 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp 
            100                 105                 110         


Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
        115                 120                 125     


<210>  32
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat domain

<400>  32

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Val Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Leu Asp Phe Lys Gly Asp Thr Pro Leu His Leu Ala Ala Ala Ser Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala His Asp Met Leu Ser Trp Thr Pro Leu His Leu Ala Gly Asp Leu 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Gln Asp Arg Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp 
            100                 105                 110         


Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
        115                 120                 125     


<210>  33
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat domain

<400>  33

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Val Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Thr Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Lys Asp Gln Phe Gly Phe Thr Pro Leu Gln Leu Ala Ala Tyr Asn Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Phe Asp Ile Phe Gly Trp Thr Pro Leu His Leu Ala Ala Asp Leu 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Gln Asp Lys Phe Gly Arg Thr Ala Phe Asp Ile Ser Ile Asp 
            100                 105                 110         


Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
        115                 120                 125     


<210>  34
<211>  127
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat domain

<400>  34

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Val Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Ser Asp Asn Gln Gly Thr Thr Pro Leu His Leu Ala Ala Ser His Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
    50                  55                  60                  


Asp Ala His Asp Asp Leu Gly Trp Thr Pro Leu His Leu Ser Ala Asp 
65                  70                  75                  80  


Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp 
                85                  90                  95      


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
            100                 105                 110         


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
        115                 120                 125         


<210>  35
<211>  127
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat domain

<400>  35

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Thr Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Ser Asp Asn Gln Gly Thr Thr Pro Leu His Leu Ala Ala Ser His Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
    50                  55                  60                  


Asp Ala His Asp Asp Leu Gly Trp Thr Pro Leu His Leu Ala Ala Asp 
65                  70                  75                  80  


Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp 
                85                  90                  95      


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
            100                 105                 110         


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
        115                 120                 125         


<210>  36
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat domain

<400>  36

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Val Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asp Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Ser Asp Phe Lys Gly Asp Thr Pro Leu His Leu Ala Ala Ser Gln Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Tyr Asp Met Leu Gly Trp Thr Pro Leu His Leu Ala Ala Asp Leu 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Gln Asp Arg Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp 
            100                 105                 110         


Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
        115                 120                 125     


<210>  37
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat domain

<400>  37

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Val Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Asp Ala Asp Val Asn Ala 
            20                  25                  30          


Ser Asp Phe Lys Gly Asp Thr Pro Leu His Leu Ala Ala Ser Gln Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Tyr Asp Met Leu Gly Trp Thr Pro Leu His Leu Ala Ala Asp Leu 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp 
            100                 105                 110         


Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
        115                 120                 125     


<210>  38
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat domain

<400>  38

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Thr 
            20                  25                  30          


Leu Asp Phe Lys Ser Asp Thr Pro Leu His Leu Ala Ala Ala Ser Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala His Asp Met Leu Ser Trp Thr Pro Leu His Leu Ala Gly Asp Leu 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp 
            100                 105                 110         


Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
        115                 120                 125     


<210>  39
<211>  159
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat domain

<400>  39

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Lys Asp Ile Tyr Gly Arg Thr Pro Leu His Leu Ala Ala Leu His Gly 
        35                  40                  45              


His Pro Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Asn Asp Tyr Trp Gly Thr Thr Ser Leu His Leu Val Ala Ile Trp 
65                  70                  75                  80  


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val 
                85                  90                  95      


Asn Ala Val Asp Asp Ile Gly Gln Thr Pro Leu His Leu Ala Ala Ala 
            100                 105                 110         


Trp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp 
        115                 120                 125             


Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile 
    130                 135                 140                 


Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
145                 150                 155                 


<210>  40
<211>  158
<212>  PRT
<213>  Artificial

<220>
<223>  Ankyrin repeat domain

<400>  40

Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      


Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          


Asn Asp Tyr Asp Gly Met Thr Pro Leu His Leu Ala Ala Met Glu Gly 
        35                  40                  45              


His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
    50                  55                  60                  


Ala Asn Asp His Tyr Gly Phe Thr Pro Leu His Leu Ala Trp Thr Gly 
65                  70                  75                  80  


Arg Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
                85                  90                  95      


Ala Ala Asp Val Phe Gly Arg Thr Pro Leu His Leu Ala Ala Thr Ser 
            100                 105                 110         


Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val 
        115                 120                 125             


Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp 
    130                 135                 140                 


Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
145                 150                 155             


<210>  41
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  GS linker

<400>  41

Gly Gly Gly Ser Gly Gly Gly Ser Cys 
1               5                   


