                         SEQUENCE LISTING

<110>  Thomas Jefferson Univeristy
       Lisanti, Michael P.
       Mercier, Isabelle
       Jasmin, Jean-Francois
       Rui, Hallgeir
       Tran, Thai Hong
       Pestell, Richard G.
	
<120>  Method for Determining Progression of Ductal Carcinoma in situ to
       Invasive Breast Cancer

<130>  37075-241-WO

<150>  US 61/199,885
<151>  2008-11-21

<160>  4     

<170>  PatentIn version 3.4

<210>  1
<211>  2809
<212>  DNA
<213>  Homo sapiens

<400>  1
tgtgtgtgtg tatgtgtgct ggtgaatgtg agtacaggga agcagcggcc gccatttcag     60

ggagcttgtc gacgctgtcg caggggtgga tcctgagctg ccgaagccgc cgtcctgctc    120

tcccgcgtgg gcttctctaa ttccattgtt ttttttagat tctctcgggc ctagccgtcc    180

ttggaacccg atattcgggc tgggcggttc cgcggcctgg gcctaggggc ttaacagtag    240

caacagaagc ggcggcggcg gcagcagcag cagcagcagc agcaatctct tcccgaacac    300

gagcaccaca ggcgcccgaa ggccggaaca ggcgtttaga gaaaatggca gacgatattg    360

atattgaagc aatgcttgag gctccttaca agaaggatga gaacaagttg agcagtgcca    420

acggccatga agaacgtagc aaaaagagga aaaaaagcaa gagcagaagt cgtagtcatg    480

aacgaaagag aagcaaaagt aaggaacgga agcgaagtag agacagagaa aggaaaaaga    540

gcaaaagccg tgaaagaaag cgaagtagaa gcaaagagag gcgacggagc cgctcaagaa    600

gtcgagatcg aagatttaga ggccgctaca gaagtcctta ctccggacca aaatttaaca    660

gtgccatccg aggaaagatt gggttgcctc atagcatcaa attaagcaga cgacgttccc    720

gaagcaaaag tccattcaga aaagacaaga gccctgtgag agaacctatt gataatttaa    780

ctcctgagga aagagatgca aggacagtct tctgtatgca gctggcggca agaattcgac    840

caagggattt ggaagagttt ttctctacag taggaaaggt tcgagatgtg aggatgattt    900

ctgacagaaa ttcaagacgt tccaaaggaa ttgcttatgt ggagttcgtc gatgttagct    960

cagtgcctct agcaatagga ttaactggcc aacgagtttt aggcgtgcca atcatagtac   1020

aggcatcaca ggcagaaaaa aacagagctg cagcaatggc aaacaattta caaaagggaa   1080

gtgctggacc tatgaggctt tatgtgggct cattacactt caacataact gaagatatgc   1140

ttcgtgggat ctttgagcct tttggaagaa ttgaaagtat ccagctgatg atggacagtg   1200

aaactggtcg atccaaggga tatggattta ttacattttc tgactcagaa tgtgccaaaa   1260

aggctttgga acaacttaat ggatttgaac tagcaggaag accaatgaaa gttggtcatg   1320

ttactgaacg tactgatgct tcgagtgcta gttcattttt ggacagtgat gaactggaaa   1380

ggactggaat tgatttggga acaactggtc gtcttcagtt aatggcaaga cttgcagagg   1440

gtacaggttt gcagattccg ccagcagcac agcaagctct acagatgagt ggctctttgg   1500

catttggtgc tgtggcagaa ttctcttttg ttatagattt gcaaacaaga ctttcccagc   1560

agactgaagc ttcagcttta gctgcagctg cctctgttca gccacttgca acacaatgtt   1620

tccaactctc taacatgttt aaccctcaaa cagaagaaga agttggatgg gataccgaga   1680

ttaaggatga tgtgattgaa gaatgtaata aacatggagg agttattcat atttatgttg   1740

acaaaaattc agctcagggc aatgtgtatg tgaagtgccc atcaattgct gcagctattg   1800

ctgctgtcaa tgcattgcat ggcaggtggt ttgctggtaa aatgataaca gcagcatatg   1860

tacctcttcc aacttaccac aacctgtttc ctgattctat gacagcaaca cagctactgg   1920

ttccaagtag acgatgaagg aagatatagt cccttatgta tatagctttt tttctttctt   1980

gagaattcat cttgagttat cttttattta gataaaaata aagaggcaag gatctactgt   2040

catttgtatg caatttcctg ttaccttgaa aaaataaaaa tgttaacagg aatgcagtgt   2100

gctcattctc cctaaatagt aaatcccact gtatacaaaa ctgttctctt gttctgcctt   2160

ttaaaatgtt catgtagaaa attaatgaac tataggaata gctctaggag aacaaatgtg   2220

ctttctgtaa aaaggcagac cagggatgta atgtttttaa tgtttcagaa gcctaacttt   2280

ttacacagtg gttacatttc acatttcact aatgttgata tttggctgat ggttgagcag   2340

tttctgaaat acacatttag tgtatggaaa tacaagacag ctaaagggct gtttggttag   2400

catctcatct tgcattctga tcaattggca agaaagggag atttcaaaat tatatttctt   2460

gatggtatct tttcaattaa tgtatctgta aaagtttctt tgtaaatact atgtgttctg   2520

gtgtgtctta aaattccaaa caaaatgatc cctgcatttc ctgaagatgt ttaaacgtga   2580

gagtctggta ggcaaagcag tctgagaaag aaataggaaa tgcagaaata ggttttgtct   2640

ggttgcatat aatctttgct ctttttaagc tctgtgagct ctgaaatata tttttgggtt   2700

acttcagtgt gtttgacaag acagcttgat atttctatca aacaaatgac tttcatattg   2760

caacaatctt tgtaagaacc actcaaataa aagtctctta aaaaggcca               2809


<210>  2
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Asp Asp Ile Asp Ile Glu Ala Met Leu Glu Ala Pro Tyr Lys 
1               5                   10                  15      


Lys Asp Glu Asn Lys Leu Ser Ser Ala Asn Gly His Glu Glu Arg Ser 
            20                  25                  30          


Lys Lys Arg Lys Lys Ser Lys Ser Arg Ser Arg Ser His Glu Arg Lys 
        35                  40                  45              


Arg Ser Lys Ser Lys Glu Arg Lys Arg Ser Arg Asp Arg Glu Arg Lys 
    50                  55                  60                  


Lys Ser Lys Ser Arg Glu Arg Lys Arg Ser Arg Ser Lys Glu Arg Arg 
65                  70                  75                  80  


Arg Ser Arg Ser Arg Ser Arg Asp Arg Arg Phe Arg Gly Arg Tyr Arg 
                85                  90                  95      


Ser Pro Tyr Ser Gly Pro Lys Phe Asn Ser Ala Ile Arg Gly Lys Ile 
            100                 105                 110         


Gly Leu Pro His Ser Ile Lys Leu Ser Arg Arg Arg Ser Arg Ser Lys 
        115                 120                 125             


Ser Pro Phe Arg Lys Asp Lys Ser Pro Val Arg Glu Pro Ile Asp Asn 
    130                 135                 140                 


Leu Thr Pro Glu Glu Arg Asp Ala Arg Thr Val Phe Cys Met Gln Leu 
145                 150                 155                 160 


Ala Ala Arg Ile Arg Pro Arg Asp Leu Glu Glu Phe Phe Ser Thr Val 
                165                 170                 175     


Gly Lys Val Arg Asp Val Arg Met Ile Ser Asp Arg Asn Ser Arg Arg 
            180                 185                 190         


Ser Lys Gly Ile Ala Tyr Val Glu Phe Val Asp Val Ser Ser Val Pro 
        195                 200                 205             


Leu Ala Ile Gly Leu Thr Gly Gln Arg Val Leu Gly Val Pro Ile Ile 
    210                 215                 220                 


Val Gln Ala Ser Gln Ala Glu Lys Asn Arg Ala Ala Ala Met Ala Asn 
225                 230                 235                 240 


Asn Leu Gln Lys Gly Ser Ala Gly Pro Met Arg Leu Tyr Val Gly Ser 
                245                 250                 255     


Leu His Phe Asn Ile Thr Glu Asp Met Leu Arg Gly Ile Phe Glu Pro 
            260                 265                 270         


Phe Gly Arg Ile Glu Ser Ile Gln Leu Met Met Asp Ser Glu Thr Gly 
        275                 280                 285             


Arg Ser Lys Gly Tyr Gly Phe Ile Thr Phe Ser Asp Ser Glu Cys Ala 
    290                 295                 300                 


Lys Lys Ala Leu Glu Gln Leu Asn Gly Phe Glu Leu Ala Gly Arg Pro 
305                 310                 315                 320 


Met Lys Val Gly His Val Thr Glu Arg Thr Asp Ala Ser Ser Ala Ser 
                325                 330                 335     


Ser Phe Leu Asp Ser Asp Glu Leu Glu Arg Thr Gly Ile Asp Leu Gly 
            340                 345                 350         


Thr Thr Gly Arg Leu Gln Leu Met Ala Arg Leu Ala Glu Gly Thr Gly 
        355                 360                 365             


Leu Gln Ile Pro Pro Ala Ala Gln Gln Ala Leu Gln Met Ser Gly Ser 
    370                 375                 380                 


Leu Ala Phe Gly Ala Val Ala Glu Phe Ser Phe Val Ile Asp Leu Gln 
385                 390                 395                 400 


Thr Arg Leu Ser Gln Gln Thr Glu Ala Ser Ala Leu Ala Ala Ala Ala 
                405                 410                 415     


Ser Val Gln Pro Leu Ala Thr Gln Cys Phe Gln Leu Ser Asn Met Phe 
            420                 425                 430         


Asn Pro Gln Thr Glu Glu Glu Val Gly Trp Asp Thr Glu Ile Lys Asp 
        435                 440                 445             


Asp Val Ile Glu Glu Cys Asn Lys His Gly Gly Val Ile His Ile Tyr 
    450                 455                 460                 


Val Asp Lys Asn Ser Ala Gln Gly Asn Val Tyr Val Lys Cys Pro Ser 
465                 470                 475                 480 


Ile Ala Ala Ala Ile Ala Ala Val Asn Ala Leu His Gly Arg Trp Phe 
                485                 490                 495     


Ala Gly Lys Met Ile Thr Ala Ala Tyr Val Pro Leu Pro Thr Tyr His 
            500                 505                 510         


Asn Leu Phe Pro Asp Ser Met Thr Ala Thr Gln Leu Leu Val Pro Ser 
        515                 520                 525             


Arg Arg 
    530 


<210>  3
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  3
gtggctcttt ggcatttggt                                                 20


<210>  4
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Chemically synthesized

<400>  4
gctgggaaag tcttgtttgc a                                               21


