                         SEQUENCE LISTING

<110>  ZymoGenetics, LLC
       Bristol-Myers Squibb Company
 
<120>  IL-29 MUTANTS AND USES THEREOF

<130>  08-16PC

<150>  US 61/116,589
<151>  2008-11-20

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  546
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(543)

<400>  1
ggc cct gtc ccc act tcc aag ccc acc aca act ggg aag ggc tgc cac         48
Gly Pro Val Pro Thr Ser Lys Pro Thr Thr Thr Gly Lys Gly Cys His           
1               5                   10                  15                

att ggc agg ttc aaa tct ctg tca cca cag gag cta gcg agc ttc aag         96
Ile Gly Arg Phe Lys Ser Leu Ser Pro Gln Glu Leu Ala Ser Phe Lys           
            20                  25                  30                    

aag gcc agg gac gcc ttg gaa gag tca ctc aag ctg aaa aac tgg agt        144
Lys Ala Arg Asp Ala Leu Glu Glu Ser Leu Lys Leu Lys Asn Trp Ser           
        35                  40                  45                        

tgc agc tct cct gtc ttc ccc ggg aat tgg gac ctg agg ctt ctc cag        192
Cys Ser Ser Pro Val Phe Pro Gly Asn Trp Asp Leu Arg Leu Leu Gln           
    50                  55                  60                            

gtg agg gag cgc cct gtg gcc ttg gag gct gag ctg gcc ctg acg ctg        240
Val Arg Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu           
65                  70                  75                  80            

aag gtc ctg gag gcc gct gct ggc cca gcc ctg gag gac gtc cta gac        288
Lys Val Leu Glu Ala Ala Ala Gly Pro Ala Leu Glu Asp Val Leu Asp           
                85                  90                  95                

cag ccc ctt cac acc ctg cac cac atc ctc tcc cag ctc cag gcc tgt        336
Gln Pro Leu His Thr Leu His His Ile Leu Ser Gln Leu Gln Ala Cys           
            100                 105                 110                   

atc cag cct cag ccc aca gca ggg ccc agg ccc cgg ggc cgc ctc cac        384
Ile Gln Pro Gln Pro Thr Ala Gly Pro Arg Pro Arg Gly Arg Leu His           
        115                 120                 125                       

cac tgg ctg cac cgg ctc cag gag gcc ccc aaa aag gag tcc gct ggc        432
His Trp Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser Ala Gly           
    130                 135                 140                           

tgc ctg gag gca tct gtc acc ttc aac ctc ttc cgc ctc ctc acg cga        480
Cys Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg           
145                 150                 155                 160           

gac ctc aaa tat gtg gcc gat ggg aac ctg tgt ctg aga acg tca acc        528
Asp Leu Lys Tyr Val Ala Asp Gly Asn Leu Cys Leu Arg Thr Ser Thr           
                165                 170                 175               

cac cct gag tcc acc tga                                                546
His Pro Glu Ser Thr                                                       
            180                                                           


<210>  2
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  2

Gly Pro Val Pro Thr Ser Lys Pro Thr Thr Thr Gly Lys Gly Cys His 
1               5                   10                  15      


Ile Gly Arg Phe Lys Ser Leu Ser Pro Gln Glu Leu Ala Ser Phe Lys 
            20                  25                  30          


Lys Ala Arg Asp Ala Leu Glu Glu Ser Leu Lys Leu Lys Asn Trp Ser 
        35                  40                  45              


Cys Ser Ser Pro Val Phe Pro Gly Asn Trp Asp Leu Arg Leu Leu Gln 
    50                  55                  60                  


Val Arg Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu 
65                  70                  75                  80  


Lys Val Leu Glu Ala Ala Ala Gly Pro Ala Leu Glu Asp Val Leu Asp 
                85                  90                  95      


Gln Pro Leu His Thr Leu His His Ile Leu Ser Gln Leu Gln Ala Cys 
            100                 105                 110         


Ile Gln Pro Gln Pro Thr Ala Gly Pro Arg Pro Arg Gly Arg Leu His 
        115                 120                 125             


His Trp Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser Ala Gly 
    130                 135                 140                 


Cys Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg 
145                 150                 155                 160 


Asp Leu Lys Tyr Val Ala Asp Gly Asn Leu Cys Leu Arg Thr Ser Thr 
                165                 170                 175     


His Pro Glu Ser Thr 
            180     


<210>  3
<211>  489
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(489)

<400>  3
cgt ttc aaa tct ctg tct ccg cag gaa ctg gct tct ttc aaa aaa gct         48
Arg Phe Lys Ser Leu Ser Pro Gln Glu Leu Ala Ser Phe Lys Lys Ala           
1               5                   10                  15                

cgt gac gct ctg gaa gaa tct ctg aaa ctg aaa aac tgg tct tgc tct         96
Arg Asp Ala Leu Glu Glu Ser Leu Lys Leu Lys Asn Trp Ser Cys Ser           
            20                  25                  30                    

tct ccg gtt ttc ccg ggt aac tgg gat ctg cgt ctg ctg cag gtt cgt        144
Ser Pro Val Phe Pro Gly Asn Trp Asp Leu Arg Leu Leu Gln Val Arg           
        35                  40                  45                        

gaa cgt ccg gtt gct ctg gaa gct gaa ctg gct ctg acc ctg aaa gtt        192
Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val           
    50                  55                  60                            

ctg gaa gct gct gca ggt cct gct ctg gaa gat gtt ctg gat cag ccg        240
Leu Glu Ala Ala Ala Gly Pro Ala Leu Glu Asp Val Leu Asp Gln Pro           
65                  70                  75                  80            

ctg cac act ctg cac cac atc ctg tct cag ctg cag gct tct att caa        288
Leu His Thr Leu His His Ile Leu Ser Gln Leu Gln Ala Ser Ile Gln           
                85                  90                  95                

ccg caa ccg acc gct ggt ccg cgt ccg cgt ggt cgt ctg cac cac tgg        336
Pro Gln Pro Thr Ala Gly Pro Arg Pro Arg Gly Arg Leu His His Trp           
            100                 105                 110                   

ctg cat cgt ctg cag gaa gct ccg aaa aaa gaa tct gct ggt tgc ctg        384
Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser Ala Gly Cys Leu           
        115                 120                 125                       

gaa gct tct gtt acc ttc aac ctg ttc cgt ctg ctg acc cgt gat ctg        432
Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu           
    130                 135                 140                           

aaa tac gtt gct gat ggt aac ctg tct ctg cgt acc tct acc cat ccg        480
Lys Tyr Val Ala Asp Gly Asn Leu Ser Leu Arg Thr Ser Thr His Pro           
145                 150                 155                 160           

gaa tct acc                                                            489
Glu Ser Thr                                                               
                                                                          


<210>  4
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  4

Arg Phe Lys Ser Leu Ser Pro Gln Glu Leu Ala Ser Phe Lys Lys Ala 
1               5                   10                  15      


Arg Asp Ala Leu Glu Glu Ser Leu Lys Leu Lys Asn Trp Ser Cys Ser 
            20                  25                  30          


Ser Pro Val Phe Pro Gly Asn Trp Asp Leu Arg Leu Leu Gln Val Arg 
        35                  40                  45              


Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val 
    50                  55                  60                  


Leu Glu Ala Ala Ala Gly Pro Ala Leu Glu Asp Val Leu Asp Gln Pro 
65                  70                  75                  80  


Leu His Thr Leu His His Ile Leu Ser Gln Leu Gln Ala Ser Ile Gln 
                85                  90                  95      


Pro Gln Pro Thr Ala Gly Pro Arg Pro Arg Gly Arg Leu His His Trp 
            100                 105                 110         


Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser Ala Gly Cys Leu 
        115                 120                 125             


Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu 
    130                 135                 140                 


Lys Tyr Val Ala Asp Gly Asn Leu Ser Leu Arg Thr Ser Thr His Pro 
145                 150                 155                 160 


Glu Ser Thr 
            


<210>  5
<211>  483
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(483)

<400>  5
aaa cca acc acc act ggt aaa ggt tgc cac atc ggt cgt ttc aaa tct         48
Lys Pro Thr Thr Thr Gly Lys Gly Cys His Ile Gly Arg Phe Lys Ser           
1               5                   10                  15                

ctg tct ccg cag gaa ctg gct tct ttc aaa aaa gct cgt gac gct ctg         96
Leu Ser Pro Gln Glu Leu Ala Ser Phe Lys Lys Ala Arg Asp Ala Leu           
            20                  25                  30                    

gaa gaa tct ctg aaa ctg aaa aac tgg tct tgc tct tct ccg gtt ttc        144
Glu Glu Ser Leu Lys Leu Lys Asn Trp Ser Cys Ser Ser Pro Val Phe           
        35                  40                  45                        

ccg ggt aac tgg gat ctg cgt ctg ctg cag gtt cgt gaa cgt ccg gtt        192
Pro Gly Asn Trp Asp Leu Arg Leu Leu Gln Val Arg Glu Arg Pro Val           
    50                  55                  60                            

gct ctg gaa gct gaa ctg gct ctg acc ctg aaa gtt ctg gaa gct gct        240
Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val Leu Glu Ala Ala           
65                  70                  75                  80            

gca ggt cct gct ctg gaa gat gtt ctg gat cag ccg ctg cac act ctg        288
Ala Gly Pro Ala Leu Glu Asp Val Leu Asp Gln Pro Leu His Thr Leu           
                85                  90                  95                

cac cac atc ctg tct cag ctg cag gct tgc att caa ccg caa ccg acc        336
His His Ile Leu Ser Gln Leu Gln Ala Cys Ile Gln Pro Gln Pro Thr           
            100                 105                 110                   

gct ggt ccg cgt ccg cgt ggt cgt ctg cac cac tgg ctg cat cgt ctg        384
Ala Gly Pro Arg Pro Arg Gly Arg Leu His His Trp Leu His Arg Leu           
        115                 120                 125                       

cag gaa gct ccg aaa aaa gaa tct gct ggt tgc ctg gaa gct tct gtt        432
Gln Glu Ala Pro Lys Lys Glu Ser Ala Gly Cys Leu Glu Ala Ser Val           
    130                 135                 140                           

acc ttc aac ctg ttc cgt ctg ctg acc cgt gat ctg aaa tac gtt gct        480
Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu Lys Tyr Val Ala           
145                 150                 155                 160           

gat                                                                    483
Asp                                                                       
                                                                          


<210>  6
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  6

Lys Pro Thr Thr Thr Gly Lys Gly Cys His Ile Gly Arg Phe Lys Ser 
1               5                   10                  15      


Leu Ser Pro Gln Glu Leu Ala Ser Phe Lys Lys Ala Arg Asp Ala Leu 
            20                  25                  30          


Glu Glu Ser Leu Lys Leu Lys Asn Trp Ser Cys Ser Ser Pro Val Phe 
        35                  40                  45              


Pro Gly Asn Trp Asp Leu Arg Leu Leu Gln Val Arg Glu Arg Pro Val 
    50                  55                  60                  


Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val Leu Glu Ala Ala 
65                  70                  75                  80  


Ala Gly Pro Ala Leu Glu Asp Val Leu Asp Gln Pro Leu His Thr Leu 
                85                  90                  95      


His His Ile Leu Ser Gln Leu Gln Ala Cys Ile Gln Pro Gln Pro Thr 
            100                 105                 110         


Ala Gly Pro Arg Pro Arg Gly Arg Leu His His Trp Leu His Arg Leu 
        115                 120                 125             


Gln Glu Ala Pro Lys Lys Glu Ser Ala Gly Cys Leu Glu Ala Ser Val 
    130                 135                 140                 


Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu Lys Tyr Val Ala 
145                 150                 155                 160 


Asp 
    


<210>  7
<211>  471
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(471)

<400>  7
aaa cca acc acc act ggt aaa ggt tgc cac atc ggt cgt ttc aaa tct         48
Lys Pro Thr Thr Thr Gly Lys Gly Cys His Ile Gly Arg Phe Lys Ser           
1               5                   10                  15                

ctg tct ccg cag gaa ctg gct tct ttc aaa aaa gct cgt gac gct ctg         96
Leu Ser Pro Gln Glu Leu Ala Ser Phe Lys Lys Ala Arg Asp Ala Leu           
            20                  25                  30                    

gaa gaa tct ctg aaa ctg aaa aac tgg tct tgc tct tct ccg gtt ttc        144
Glu Glu Ser Leu Lys Leu Lys Asn Trp Ser Cys Ser Ser Pro Val Phe           
        35                  40                  45                        

ccg ggt aac tgg gat ctg cgt ctg ctg cag gtt cgt gaa cgt ccg gtt        192
Pro Gly Asn Trp Asp Leu Arg Leu Leu Gln Val Arg Glu Arg Pro Val           
    50                  55                  60                            

gct ctg gaa gct gaa ctg gct ctg acc ctg aaa gtt ctg gaa gct gct        240
Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val Leu Glu Ala Ala           
65                  70                  75                  80            

gca ggt cct gct ctg gaa gat gtt ctg gat cag ccg ctg cac act ctg        288
Ala Gly Pro Ala Leu Glu Asp Val Leu Asp Gln Pro Leu His Thr Leu           
                85                  90                  95                

cac cac atc ctg tct cag ctg cag gct tgc att caa ccg caa ccg acc        336
His His Ile Leu Ser Gln Leu Gln Ala Cys Ile Gln Pro Gln Pro Thr           
            100                 105                 110                   

gct ggt ccg cgt ccg cgt ggt cgt ctg cac cac tgg ctg cat cgt ctg        384
Ala Gly Pro Arg Pro Arg Gly Arg Leu His His Trp Leu His Arg Leu           
        115                 120                 125                       

cag gaa gct ccg aaa aaa gaa tct gct ggt tgc ctg gaa gct tct gtt        432
Gln Glu Ala Pro Lys Lys Glu Ser Ala Gly Cys Leu Glu Ala Ser Val           
    130                 135                 140                           

acc ttc aac ctg ttc cgt ctg ctg acc cgt gat ctg aaa                    471
Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu Lys                       
145                 150                 155                               


<210>  8
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  8

Lys Pro Thr Thr Thr Gly Lys Gly Cys His Ile Gly Arg Phe Lys Ser 
1               5                   10                  15      


Leu Ser Pro Gln Glu Leu Ala Ser Phe Lys Lys Ala Arg Asp Ala Leu 
            20                  25                  30          


Glu Glu Ser Leu Lys Leu Lys Asn Trp Ser Cys Ser Ser Pro Val Phe 
        35                  40                  45              


Pro Gly Asn Trp Asp Leu Arg Leu Leu Gln Val Arg Glu Arg Pro Val 
    50                  55                  60                  


Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val Leu Glu Ala Ala 
65                  70                  75                  80  


Ala Gly Pro Ala Leu Glu Asp Val Leu Asp Gln Pro Leu His Thr Leu 
                85                  90                  95      


His His Ile Leu Ser Gln Leu Gln Ala Cys Ile Gln Pro Gln Pro Thr 
            100                 105                 110         


Ala Gly Pro Arg Pro Arg Gly Arg Leu His His Trp Leu His Arg Leu 
        115                 120                 125             


Gln Glu Ala Pro Lys Lys Glu Ser Ala Gly Cys Leu Glu Ala Ser Val 
    130                 135                 140                 


Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu Lys 
145                 150                 155         


<210>  9
<211>  447
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(447)

<400>  9
cgt ttc aaa tct ctg tct ccg cag gaa ctg gct tct ttc aaa aaa gct         48
Arg Phe Lys Ser Leu Ser Pro Gln Glu Leu Ala Ser Phe Lys Lys Ala           
1               5                   10                  15                

cgt gac gct ctg gaa gaa tct ctg aaa ctg aaa aac tgg tct tgc tct         96
Arg Asp Ala Leu Glu Glu Ser Leu Lys Leu Lys Asn Trp Ser Cys Ser           
            20                  25                  30                    

tct ccg gtt ttc ccg ggt aac tgg gat ctg cgt ctg ctg cag gtt cgt        144
Ser Pro Val Phe Pro Gly Asn Trp Asp Leu Arg Leu Leu Gln Val Arg           
        35                  40                  45                        

gaa cgt ccg gtt gct ctg gaa gct gaa ctg gct ctg acc ctg aaa gtt        192
Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val           
    50                  55                  60                            

ctg gaa gct gct gca ggt cct gct ctg gaa gat gtt ctg gat cag ccg        240
Leu Glu Ala Ala Ala Gly Pro Ala Leu Glu Asp Val Leu Asp Gln Pro           
65                  70                  75                  80            

ctg cac act ctg cac cac atc ctg tct cag ctg cag gct tct att caa        288
Leu His Thr Leu His His Ile Leu Ser Gln Leu Gln Ala Ser Ile Gln           
                85                  90                  95                

ccg caa ccg acc gct ggt ccg cgt ccg cgt ggt cgt ctg cac cac tgg        336
Pro Gln Pro Thr Ala Gly Pro Arg Pro Arg Gly Arg Leu His His Trp           
            100                 105                 110                   

ctg cat cgt ctg cag gaa gct ccg aaa aaa gaa tct gct ggt tgc ctg        384
Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser Ala Gly Cys Leu           
        115                 120                 125                       

gaa gct tct gtt acc ttc aac ctg ttc cgt ctg ctg acc cgt gat ctg        432
Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu           
    130                 135                 140                           

aaa tac gtt gct gat                                                    447
Lys Tyr Val Ala Asp                                                       
145                                                                       


<210>  10
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  10

Arg Phe Lys Ser Leu Ser Pro Gln Glu Leu Ala Ser Phe Lys Lys Ala 
1               5                   10                  15      


Arg Asp Ala Leu Glu Glu Ser Leu Lys Leu Lys Asn Trp Ser Cys Ser 
            20                  25                  30          


Ser Pro Val Phe Pro Gly Asn Trp Asp Leu Arg Leu Leu Gln Val Arg 
        35                  40                  45              


Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val 
    50                  55                  60                  


Leu Glu Ala Ala Ala Gly Pro Ala Leu Glu Asp Val Leu Asp Gln Pro 
65                  70                  75                  80  


Leu His Thr Leu His His Ile Leu Ser Gln Leu Gln Ala Ser Ile Gln 
                85                  90                  95      


Pro Gln Pro Thr Ala Gly Pro Arg Pro Arg Gly Arg Leu His His Trp 
            100                 105                 110         


Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser Ala Gly Cys Leu 
        115                 120                 125             


Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu 
    130                 135                 140                 


Lys Tyr Val Ala Asp 
145                 


<210>  11
<211>  435
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(435)

<400>  11
cgt ttc aaa tct ctg tct ccg cag gaa ctg gct tct ttc aaa aaa gct         48
Arg Phe Lys Ser Leu Ser Pro Gln Glu Leu Ala Ser Phe Lys Lys Ala           
1               5                   10                  15                

cgt gac gct ctg gaa gaa tct ctg aaa ctg aaa aac tgg tct tgc tct         96
Arg Asp Ala Leu Glu Glu Ser Leu Lys Leu Lys Asn Trp Ser Cys Ser           
            20                  25                  30                    

tct ccg gtt ttc ccg ggt aac tgg gat ctg cgt ctg ctg cag gtt cgt        144
Ser Pro Val Phe Pro Gly Asn Trp Asp Leu Arg Leu Leu Gln Val Arg           
        35                  40                  45                        

gaa cgt ccg gtt gct ctg gaa gct gaa ctg gct ctg acc ctg aaa gtt        192
Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val           
    50                  55                  60                            

ctg gaa gct gct gca ggt cct gct ctg gaa gat gtt ctg gat cag ccg        240
Leu Glu Ala Ala Ala Gly Pro Ala Leu Glu Asp Val Leu Asp Gln Pro           
65                  70                  75                  80            

ctg cac act ctg cac cac atc ctg tct cag ctg cag gct tct att caa        288
Leu His Thr Leu His His Ile Leu Ser Gln Leu Gln Ala Ser Ile Gln           
                85                  90                  95                

ccg caa ccg acc gct ggt ccg cgt ccg cgt ggt cgt ctg cac cac tgg        336
Pro Gln Pro Thr Ala Gly Pro Arg Pro Arg Gly Arg Leu His His Trp           
            100                 105                 110                   

ctg cat cgt ctg cag gaa gct ccg aaa aaa gaa tct gct ggt tgc ctg        384
Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser Ala Gly Cys Leu           
        115                 120                 125                       

gaa gct tct gtt acc ttc aac ctg ttc cgt ctg ctg acc cgt gat ctg        432
Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu           
    130                 135                 140                           

aaa                                                                    435
Lys                                                                       
145                                                                       


<210>  12
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  12

Arg Phe Lys Ser Leu Ser Pro Gln Glu Leu Ala Ser Phe Lys Lys Ala 
1               5                   10                  15      


Arg Asp Ala Leu Glu Glu Ser Leu Lys Leu Lys Asn Trp Ser Cys Ser 
            20                  25                  30          


Ser Pro Val Phe Pro Gly Asn Trp Asp Leu Arg Leu Leu Gln Val Arg 
        35                  40                  45              


Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val 
    50                  55                  60                  


Leu Glu Ala Ala Ala Gly Pro Ala Leu Glu Asp Val Leu Asp Gln Pro 
65                  70                  75                  80  


Leu His Thr Leu His His Ile Leu Ser Gln Leu Gln Ala Ser Ile Gln 
                85                  90                  95      


Pro Gln Pro Thr Ala Gly Pro Arg Pro Arg Gly Arg Leu His His Trp 
            100                 105                 110         


Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser Ala Gly Cys Leu 
        115                 120                 125             


Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu 
    130                 135                 140                 


Lys 
145 


<210>  13
<211>  531
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(531)

<400>  13
atg aaa cca acc acc act ggt aaa ggt tgc cac atc ggt cgt ttc aaa         48
Met Lys Pro Thr Thr Thr Gly Lys Gly Cys His Ile Gly Arg Phe Lys           
1               5                   10                  15                

tct ctg tct ccg cag gaa ctg gct tct ttc aaa aaa gct cgt gac gct         96
Ser Leu Ser Pro Gln Glu Leu Ala Ser Phe Lys Lys Ala Arg Asp Ala           
            20                  25                  30                    

ctg gaa gaa tct ctg aaa ctg aaa aac tgg tct tgc tct tct ccg gtt        144
Leu Glu Glu Ser Leu Lys Leu Lys Asn Trp Ser Cys Ser Ser Pro Val           
        35                  40                  45                        

ttc ccg ggt aac tgg gat ctg cgt ctg ctg cag gtt cgt gaa cgt ccg        192
Phe Pro Gly Asn Trp Asp Leu Arg Leu Leu Gln Val Arg Glu Arg Pro           
    50                  55                  60                            

gtt gct ctg gaa gct gaa ctg gct ctg acc ctg aaa gtt ctg gaa gct        240
Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val Leu Glu Ala           
65                  70                  75                  80            

gct gca ggt cct gct ctg gaa gat gtt ctg gat cag ccg ctg cac act        288
Ala Ala Gly Pro Ala Leu Glu Asp Val Leu Asp Gln Pro Leu His Thr           
                85                  90                  95                

ctg cac cac atc ctg tct cag ctg cag gct tgc att caa ccg caa ccg        336
Leu His His Ile Leu Ser Gln Leu Gln Ala Cys Ile Gln Pro Gln Pro           
            100                 105                 110                   

acc gct ggt ccg cgt ccg cgt ggt cgt ctg cac cac tgg ctg cat cgt        384
Thr Ala Gly Pro Arg Pro Arg Gly Arg Leu His His Trp Leu His Arg           
        115                 120                 125                       

ctg cag gaa gct ccg aaa aaa gaa tct gct ggt tgc ctg gaa gct tct        432
Leu Gln Glu Ala Pro Lys Lys Glu Ser Ala Gly Cys Leu Glu Ala Ser           
    130                 135                 140                           

gtt acc ttc aac ctg ttc cgt ctg ctg acc cgt gat ctg aaa tac gtt        480
Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu Lys Tyr Val           
145                 150                 155                 160           

gct gat ggt aac ctg tct ctg cgt acc tct acc cat ccg gaa tct acc        528
Ala Asp Gly Asn Leu Ser Leu Arg Thr Ser Thr His Pro Glu Ser Thr           
                165                 170                 175               

taa                                                                    531


<210>  14
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Lys Pro Thr Thr Thr Gly Lys Gly Cys His Ile Gly Arg Phe Lys 
1               5                   10                  15      


Ser Leu Ser Pro Gln Glu Leu Ala Ser Phe Lys Lys Ala Arg Asp Ala 
            20                  25                  30          


Leu Glu Glu Ser Leu Lys Leu Lys Asn Trp Ser Cys Ser Ser Pro Val 
        35                  40                  45              


Phe Pro Gly Asn Trp Asp Leu Arg Leu Leu Gln Val Arg Glu Arg Pro 
    50                  55                  60                  


Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val Leu Glu Ala 
65                  70                  75                  80  


Ala Ala Gly Pro Ala Leu Glu Asp Val Leu Asp Gln Pro Leu His Thr 
                85                  90                  95      


Leu His His Ile Leu Ser Gln Leu Gln Ala Cys Ile Gln Pro Gln Pro 
            100                 105                 110         


Thr Ala Gly Pro Arg Pro Arg Gly Arg Leu His His Trp Leu His Arg 
        115                 120                 125             


Leu Gln Glu Ala Pro Lys Lys Glu Ser Ala Gly Cys Leu Glu Ala Ser 
    130                 135                 140                 


Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu Lys Tyr Val 
145                 150                 155                 160 


Ala Asp Gly Asn Leu Ser Leu Arg Thr Ser Thr His Pro Glu Ser Thr 
                165                 170                 175     


