                              Sequence Listing

<110> Genentech, Inc.
      Bagri, Anil D.      
      Koch, Alexanxer W.
      Wu, Yan
      Watts, Ryan J.
      

<120> ANTI-UNC5B ANTIBODIES AND METHODS OF USE

<130> P4286R1 WO


<150> US 61/246,026
<151> 2009-09-25

<150> US 61/116,596
<151> 2008-11-20

<160> 32

<210> 1
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 1
 Phe Thr Phe Thr Gly Ser Ser Ile His
                   5                

<210> 2
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 2
 Gly Trp Ile Thr Pro Asn Gly Gly Tyr Thr Asn
                   5                  10    

<210> 3
<211> 13
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 3
 Arg Gln Ser Trp Val Leu Arg Gly Trp Ala Met Asp Tyr
                   5                  10            

<210> 4
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 4
 Phe Thr Phe Ser Ser Tyr Trp Ile Ser
                   5                

<210> 5
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 5
 Gly Asn Ile Tyr Pro Ala Gly Gly Tyr Thr Asp
                   5                  10    

<210> 6
<211> 12
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 6
 Arg Ser Gly Trp Phe Gly Val Gly Tyr Phe Asp Tyr
                   5                  10        

<210> 7
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 7
 Phe Thr Phe Thr Asn Tyr Asp Ile His
                   5                

<210> 8
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 8
 Gly Trp Ile Ser Pro Ser Gly Gly Tyr Thr Asn
                   5                  10    

<210> 9
<211> 13
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 9
 Arg Gln Leu Trp Ala Val Arg Gly Trp Val Met Asp Tyr
                   5                  10            

<210> 10
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 10
 Phe Thr Phe Ser Asp Asn Trp Ile Ser
                   5                

<210> 11
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 11
 Gly Gly Ile Tyr Pro Ala Gly Gly Tyr Thr Tyr
                   5                  10    

<210> 12
<211> 12
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 12
 His Asp Ile His Thr Arg Ile Ala Val Met Asp Tyr
                   5                  10        

<210> 13
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 13
 Phe Thr Phe Ser Asn Thr Ser Ile His
                   5                

<210> 14
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 14
 Ala Gly Ile Tyr Pro Thr Ser Gly Tyr Thr Asn
                   5                  10    

<210> 15
<211> 15
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 15
 Arg Trp Ser Gly His Arg Arg Ser Thr Val Tyr Gly Met Asp Tyr
   1               5                  10                  15

<210> 16
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 16
 Phe Thr Phe Ser Asn Ser Gly Ile Ser
                   5                

<210> 17
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 17
 Gly Tyr Ile Tyr Pro Asp Asn Gly Ser Thr Asn
                   5                  10    

<210> 18
<211> 8
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 18
 Arg Gly Val Trp Trp Phe Asp Tyr
                   5            

<210> 19
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 19
 Phe Thr Phe Thr Asn Thr Trp Ile Ser
                   5                

<210> 20
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 20
 Gly Trp Ile Tyr Pro Ala Gly Gly Tyr Thr Asn
                   5                  10    

<210> 21
<211> 12
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 21
 Arg Asn Lys Leu Tyr Gly Ile Gly Tyr Phe Asp Tyr
                   5                  10        

<210> 22
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 22
 Asp Val Ser Thr Ala Val Ala
                   5        

<210> 23
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 23
 Ser Ala Ser Phe Leu Tyr Ser
                   5        

<210> 24
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 24
 Gln Ser Tyr Thr Thr Pro Pro
                   5        

<210> 25
<211> 119
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 25
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr
                  20                  25                  30

 Gly Ser Ser Ile His Trp Val Arg Gln Ala Pro Lys Gly Leu Glu
                  35                  40                  45

 Trp Val Gly Trp Ile Thr Pro Asn Gly Gly Tyr Thr Asn Tyr Ala
                  50                  55                  60

 Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys
                  65                  70                  75

 Asn Thr Ala Tyr Leu Gln Met Ser Leu Arg Ala Glu Asp Thr Ala
                  80                  85                  90

 Val Tyr Tyr Cys Ala Arg Gln Ser Trp Val Leu Arg Gly Trp Ala
                  95                 100                 105

 Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                 115                

<210> 26
<211> 118
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 26
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
                  20                  25                  30

 Ser Tyr Trp Ile Ser Trp Val Arg Gln Ala Pro Lys Gly Leu Glu
                  35                  40                  45

 Trp Val Gly Asn Ile Tyr Pro Ala Gly Gly Tyr Thr Asp Tyr Ala
                  50                  55                  60

 Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys
                  65                  70                  75

 Asn Thr Ala Tyr Leu Gln Met Ser Leu Arg Ala Glu Asp Thr Ala
                  80                  85                  90

 Val Tyr Tyr Cys Ala Arg Ser Gly Trp Phe Gly Val Gly Tyr Phe
                  95                 100                 105

 Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                 115            

<210> 27
<211> 119
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 27
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr
                  20                  25                  30

 Asn Tyr Asp Ile His Trp Val Arg Gln Ala Pro Lys Gly Leu Glu
                  35                  40                  45

 Trp Val Gly Trp Ile Ser Pro Ser Gly Gly Tyr Thr Asn Tyr Ala
                  50                  55                  60

 Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys
                  65                  70                  75

 Asn Thr Ala Tyr Leu Gln Met Ser Leu Arg Ala Glu Asp Thr Ala
                  80                  85                  90

 Val Tyr Tyr Cys Ala Arg Gln Leu Trp Ala Val Arg Gly Trp Val
                  95                 100                 105

 Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                 115                

<210> 28
<211> 118
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 28
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
                  20                  25                  30

 Asp Asn Trp Ile Ser Trp Val Arg Gln Ala Pro Lys Gly Leu Glu
                  35                  40                  45

 Trp Val Gly Gly Ile Tyr Pro Ala Gly Gly Tyr Thr Tyr Tyr Ala
                  50                  55                  60

 Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys
                  65                  70                  75

 Asn Thr Ala Tyr Leu Gln Met Ser Leu Arg Ala Glu Asp Thr Ala
                  80                  85                  90

 Val Tyr Tyr Cys Ala His Asp Ile His Thr Arg Ile Ala Val Met
                  95                 100                 105

 Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                 115            

<210> 29
<211> 121
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 29
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
                  20                  25                  30

 Asn Thr Ser Ile His Trp Val Arg Gln Ala Pro Lys Gly Leu Glu
                  35                  40                  45

 Trp Val Ala Gly Ile Tyr Pro Thr Ser Gly Tyr Thr Asn Tyr Ala
                  50                  55                  60

 Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys
                  65                  70                  75

 Asn Thr Ala Tyr Leu Gln Met Ser Leu Arg Ala Glu Asp Thr Ala
                  80                  85                  90

 Val Tyr Tyr Cys Ala Arg Trp Ser Gly His Arg Arg Ser Thr Val
                  95                 100                 105

 Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
                 110                 115                 120

 Ser
    

<210> 30
<211> 114
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 30
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
                  20                  25                  30

 Asn Ser Gly Ile Ser Trp Val Arg Gln Ala Pro Lys Gly Leu Glu
                  35                  40                  45

 Trp Val Gly Tyr Ile Tyr Pro Asp Asn Gly Ser Thr Asn Tyr Ala
                  50                  55                  60

 Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys
                  65                  70                  75

 Asn Thr Ala Tyr Leu Gln Met Ser Leu Arg Ala Glu Asp Thr Ala
                  80                  85                  90

 Val Tyr Tyr Cys Ala Arg Gly Val Trp Trp Phe Asp Tyr Trp Gly
                  95                 100                 105

 Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                

<210> 31
<211> 118
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 31
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr
                  20                  25                  30

 Asn Thr Trp Ile Ser Trp Val Arg Gln Ala Pro Lys Gly Leu Glu
                  35                  40                  45

 Trp Val Gly Trp Ile Tyr Pro Ala Gly Gly Tyr Thr Asn Tyr Ala
                  50                  55                  60

 Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys
                  65                  70                  75

 Asn Thr Ala Tyr Leu Gln Met Ser Leu Arg Ala Glu Asp Thr Ala
                  80                  85                  90

 Val Tyr Tyr Cys Ala Arg Asn Lys Leu Tyr Gly Ile Gly Tyr Phe
                  95                 100                 105

 Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                 115            

<210> 32
<211> 108
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 32
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser
                  20                  25                  30

 Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Thr Tyr Cys Gln Gln
                  80                  85                  90

 Ser Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys Arg
            

