                         SEQUENCE LISTING

<110>  VGX Pharmaceuticals, LLC
 
<120>  ANTIGENS THAT ELICIT IMMUNE RESPONSE AGAINST FLAVIVIRUS AND 
       METHODS OF USING SAME

<130>  VGX0107 WO

<150>  US61/115,535
<151>  2008-11-17

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JEV DIII consensus sequence

<400>  1

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Ala Leu Lys Gly Thr Thr Tyr Gly Met Cys Thr Glu Lys Phe 
            20                  25                  30          


Ser Phe Ala Lys Asn Pro Ala Asp Thr Gly His Gly Thr Val Val Ile 
        35                  40                  45              


Glu Leu Ser Tyr Ser Gly Ser Asp Gly Pro Cys Lys Ile Pro Ile Val 
    50                  55                  60                  


Ser Val Ala Ser Leu Asn Asp Met Thr Pro Val Gly Arg Leu Val Thr 
65                  70                  75                  80  


Val Asn Pro Phe Val Ala Thr Ser Ser Ala Asn Ser Lys Val Leu Val 
                85                  90                  95      


Glu Met Glu Pro Pro Phe Gly Asp Ser Tyr Ile Val Val Gly Arg Gly 
            100                 105                 110         


Asp Lys Gln Ile Asn His His Trp His Lys Ala Gly Ser Thr Leu Gly 
        115                 120                 125             


Lys Ala Phe Ser Thr Thr Leu Lys Gly Ala Gln 
    130                 135                 


<210>  2
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WNV DIII Consensus Sequence

<400>  2

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Gln Leu Lys Gly Thr Thr Tyr Gly Val Cys Ser Lys Ala Phe 
            20                  25                  30          


Lys Phe Leu Gly Thr Pro Ala Asp Thr Gly His Gly Thr Val Val Leu 
        35                  40                  45              


Glu Leu Gln Tyr Thr Gly Thr Asp Gly Pro Cys Lys Val Pro Ile Ser 
    50                  55                  60                  


Ser Val Ala Ser Leu Asn Asp Leu Thr Pro Val Gly Arg Leu Val Thr 
65                  70                  75                  80  


Val Asn Pro Phe Val Ser Val Ala Thr Ala Asn Ala Lys Val Leu Ile 
                85                  90                  95      


Glu Leu Glu Pro Pro Phe Gly Asp Ser Tyr Ile Val Val Gly Arg Gly 
            100                 105                 110         


Glu Gln Gln Ile Asn His His Trp His Lys Ser Gly Ser Ser Ile Gly 
        115                 120                 125             


Lys Ala Phe Thr Thr Thr Leu Lys Gly Ala Gln 
    130                 135                 


<210>  3
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JW DIII Consensus Sequence

<400>  3

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Ala Leu Lys Gly Thr Thr Tyr Gly Met Cys Thr Ser Lys Phe 
            20                  25                  30          


Ser Lys Ala Lys Asn Pro Pro Asp Thr Gly His Gly Thr Val Val Ile 
        35                  40                  45              


Glu Leu Ser Tyr Ser Thr Ser Thr Gly Pro Cys Lys Ile Pro Ile Val 
    50                  55                  60                  


Ser Val Ala Ser Leu Asn Asp Met Thr Pro Val Gly Arg Leu Val Thr 
65                  70                  75                  80  


Val Asn Pro Phe Val Ala Thr Ser Ser Ala Asn Ser Lys Val Leu Val 
                85                  90                  95      


Glu Met Glu Pro Pro Phe Gly Asp Ser Tyr Ile Val Val Gly Arg Gly 
            100                 105                 110         


Asp Lys Gln Ile Asn His His Trp His Lys Ala Gly Ser Thr Leu Gly 
        115                 120                 125             


Lys Ala Phe Ser Thr Thr Leu Lys Gly Ala Gln 
    130                 135                 


<210>  4
<211>  423
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  JEV DIII

<400>  4
atggactgga cctggatcct gttcctggtg gctgctgcca ctagagtgca cagcgccctg       60

aagggcacca cctacggcat gtgcaccgag aagttcagct tcgccaagaa ccccgccgac      120

accggccacg gcaccgtggt gatcgagctg tcctacagcg gcagcgacgg cccctgcaag      180

atccccatcg tgagcgtggc cagcctgaac gacatgaccc ccgtgggccg gctggtgacc      240

gtgaacccct tcgtggccac ctccagcgcc aacagcaagg tgctggtcga gatggaaccc      300

cccttcggcg acagctacat cgtggtgggc aggggcgaca agcagatcaa ccaccactgg      360

cacaaggccg gcagcaccct gggcaaggcc ttcagcacca cactgaaggg cgcccagtga      420

tga                                                                    423


<210>  5
<211>  423
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WNV DIII

<400>  5
atggactgga cctggatcct gttcctggtg gctgctgcca ctagggtgca cagcctccag       60

ctgaagggca ccacctacgg cgtgtgcagc aaggccttca agttcctggg cacccctgcc      120

gataccggcc acggcaccgt ggtgctggaa ctccagtaca ccggcaccga cggcccctgc      180

aaggtgccca tcagcagcgt ggccagcctg aacgacctga cccccgtggg ccggctggtg      240

accgtgaacc ccttcgtgag cgtggccacc gccaacgcca aggtgctgat cgagctggaa      300

ccccccttcg gcgacagcta catcgtggtg ggcaggggcg agcagcagat caaccaccac      360

tggcacaaga gcggcagcag catcggcaag gcctttacca ccaccctgaa gggcgcctga      420

tga                                                                    423


<210>  6
<211>  423
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  JW DIII

<400>  6
atggactgga cctggatcct gttcctggtg gctgctgcca ctagagtgca cagcgccctg       60

aagggcacca cctacggcat gtgcaccagc aagttcagca aggccaagaa cccccccgac      120

accggccacg gcaccgtggt gatcgagctg tcctacagca ccagcaccgg cccctgcaag      180

atccccatcg tgagcgtggc cagcctgaac gacatgaccc ccgtgggccg gctggtgacc      240

gtgaacccct tcgtggccac ctccagcgcc aacagcaagg tgctggtcga gatggaaccc      300

cccttcggcg acagctacat cgtggtgggc aggggcgaca agcagatcaa ccaccactgg      360

cacaaggccg gcagcaccct gggcaaggcc ttcagcacca cactgaaggg cgcccagtga      420

tga                                                                    423


<210>  7
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE leader

<400>  7

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser 
        


<210>  8
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgE Leader

<400>  8
ggtaccggat ccgccaccat ggactggacc tggattctgt tcctcgtggc tgctgctaca       60

agagtgcaca gc                                                           72


<210>  9
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JEV DIII consensus sequence

<400>  9

Met Ala Leu Lys Gly Thr Thr Tyr Gly Met Cys Thr Glu Lys Phe Ser 
1               5                   10                  15      


Phe Ala Lys Asn Pro Ala Asp Thr Gly His Gly Thr Val Val Ile Glu 
            20                  25                  30          


Leu Ser Tyr Ser Gly Ser Asp Gly Pro Cys Lys Ile Pro Ile Val Ser 
        35                  40                  45              


Val Ala Ser Leu Asn Asp Met Thr Pro Val Gly Arg Leu Val Thr Val 
    50                  55                  60                  


Asn Pro Phe Val Ala Thr Ser Ser Ala Asn Ser Lys Val Leu Val Glu 
65                  70                  75                  80  


Met Glu Pro Pro Phe Gly Asp Ser Tyr Ile Val Val Gly Arg Gly Asp 
                85                  90                  95      


Lys Gln Ile Asn His His Trp His Lys Ala Gly Ser Thr Leu Gly Lys 
            100                 105                 110         


Ala Phe Ser Thr Thr Leu Lys Gly Ala Gln 
        115                 120         


<210>  10
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WNV DIII consensus sequence

<400>  10

Met Gln Leu Lys Gly Thr Thr Tyr Gly Val Cys Ser Lys Ala Phe Lys 
1               5                   10                  15      


Phe Leu Gly Thr Pro Ala Asp Thr Gly His Gly Thr Val Val Leu Glu 
            20                  25                  30          


Leu Gln Tyr Thr Gly Thr Asp Gly Pro Cys Lys Val Pro Ile Ser Ser 
        35                  40                  45              


Val Ala Ser Leu Asn Asp Leu Thr Pro Val Gly Arg Leu Val Thr Val 
    50                  55                  60                  


Asn Pro Phe Val Ser Val Ala Thr Ala Asn Ala Lys Val Leu Ile Glu 
65                  70                  75                  80  


Leu Glu Pro Pro Phe Gly Asp Ser Tyr Ile Val Val Gly Arg Gly Glu 
                85                  90                  95      


Gln Gln Ile Asn His His Trp His Lys Ser Gly Ser Ser Ile Gly Lys 
            100                 105                 110         


Ala Phe Thr Thr Thr Leu Lys Gly Ala Gln 
        115                 120         


<210>  11
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JW DIII consensus sequence

<400>  11

Met Ala Leu Lys Gly Thr Thr Tyr Gly Met Cys Thr Ser Lys Phe Ser 
1               5                   10                  15      


Lys Ala Lys Asn Pro Pro Asp Thr Gly His Gly Thr Val Val Ile Glu 
            20                  25                  30          


Leu Ser Tyr Ser Thr Ser Thr Gly Pro Cys Lys Ile Pro Ile Val Ser 
        35                  40                  45              


Val Ala Ser Leu Asn Asp Met Thr Pro Val Gly Arg Leu Val Thr Val 
    50                  55                  60                  


Asn Pro Phe Val Ala Thr Ser Ser Ala Asn Ser Lys Val Leu Val Glu 
65                  70                  75                  80  


Met Glu Pro Pro Phe Gly Asp Ser Tyr Ile Val Val Gly Arg Gly Asp 
                85                  90                  95      


Lys Gln Ile Asn His His Trp His Lys Ala Gly Ser Thr Leu Gly Lys 
            100                 105                 110         


Ala Phe Ser Thr Thr Leu Lys Gly Ala Gln 
        115                 120         


<210>  12
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  JEV DIII DNA

<400>  12
atggccctga agggcaccac ctacggcatg tgcaccgaga agttcagctt cgccaagaac       60

cccgccgaca ccggccacgg caccgtggtg atcgagctgt cctacagcgg cagcgacggc      120

ccctgcaaga tccccatcgt gagcgtggcc agcctgaacg acatgacccc cgtgggccgg      180

ctggtgaccg tgaacccctt cgtggccacc tccagcgcca acagcaaggt gctggtcgag      240

atggaacccc ccttcggcga cagctacatc gtggtgggca ggggcgacaa gcagatcaac      300

caccactggc acaaggccgg cagcaccctg ggcaaggcct tcagcaccac actgaagggc      360

gcccagtgat ga                                                          372


<210>  13
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WNV DIII DNA

<400>  13
atgctccagc tgaagggcac cacctacggc gtgtgcagca aggccttcaa gttcctgggc       60

acccctgccg ataccggcca cggcaccgtg gtgctggaac tccagtacac cggcaccgac      120

ggcccctgca aggtgcccat cagcagcgtg gccagcctga acgacctgac ccccgtgggc      180

cggctggtga ccgtgaaccc cttcgtgagc gtggccaccg ccaacgccaa ggtgctgatc      240

gagctggaac cccccttcgg cgacagctac atcgtggtgg gcaggggcga gcagcagatc      300

aaccaccact ggcacaagag cggcagcagc atcggcaagg cctttaccac caccctgaag      360

ggcgcctgat ga                                                          372


<210>  14
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  JW DIII DNA

<400>  14
atggccctga agggcaccac ctacggcatg tgcaccagca agttcagcaa ggccaagaac       60

ccccccgaca ccggccacgg caccgtggtg atcgagctgt cctacagcac cagcaccggc      120

ccctgcaaga tccccatcgt gagcgtggcc agcctgaacg acatgacccc cgtgggccgg      180

ctggtgaccg tgaacccctt cgtggccacc tccagcgcca acagcaaggt gctggtcgag      240

atggaacccc ccttcggcga cagctacatc gtggtgggca ggggcgacaa gcagatcaac      300

caccactggc acaaggccgg cagcaccctg ggcaaggcct tcagcaccac actgaagggc      360

gcccagtgat ga                                                          372


<210>  15
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kozak sequence

<400>  15
ggtaccgcca cc                                                           12


