                         SEQUENCE LISTING

<110>  Schering Corp.
 
<120>  BETAG1-IgG Intron for Enhanced Anti-IGF1R Expression

<130>  UB06856

<150>  61/113,807
<151>  2008-11-12

<160>  48    

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kozak consensus sequence

<400>  1
gccgccacca tgg                                                          13


<210>  2
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kozak consensus sequence

<400>  2
gccgccacca tg                                                           12


<210>  3
<211>  194
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Hybrid intron comprising the beta-globin splice donor and the Ig.
       splice acceptor

<400>  3
attaatacga ctcactatag caattgcacg tgtggccaca ggtaagttta aagctcaggt       60

cgagaccggg cctttgtccg gcgctccctt ggagcctacc tagactcagc cggctctcca      120

cgctttgcct gaccctgctt gctcaactct acgtctttgt ttcgttttct gttcctttct      180

ctccacaggc ttaa                                                         194


<210>  4
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  beta-globin splice donor site

<400>  4
caggtaagtt ta                                                           12


<210>  5
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ig. splice acceptor site

<400>  5
tttctctcca caggc                                                        15


<210>  6
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Pro Ser Gln Leu Ile Gly Phe Leu Leu Leu Trp Val Pro Ala 
1               5                   10                  15      


Ser Arg Gly Glu Ile Val Leu Thr Gln Val Pro Asp Phe Gln Ser Val 
            20                  25                  30          


Thr Pro Lys Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile 
        35                  40                  45              


Gly Ser Ser Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys 
    50                  55                  60                  


Leu Leu Ile Lys Tyr Ala Ser Gln Ser Leu Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser 
                85                  90                  95      


Leu Glu Ala Glu Asp Ala Ala Ala Tyr Tyr Cys His Gln Ser Ser Arg 
            100                 105                 110         


Leu Pro His Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             


<210>  7
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val His 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Phe Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Ser Val Ile Asp Thr Arg Gly Ala Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Met Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Leu Gly Asn Phe Tyr Tyr Gly Met Asp Val Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135         


<210>  8
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ser Pro Ser Gln Leu Ile Gly Phe Leu Leu Leu Trp Val Pro Ala 
1               5                   10                  15      


Ser Arg Gly Glu Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ser Val 
            20                  25                  30          


Thr Pro Gly Glu Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile 
        35                  40                  45              


Gly Ser Ser Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys 
    50                  55                  60                  


Leu Leu Ile Lys Tyr Ala Ser Gln Ser Leu Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Glu Ala Glu Asp Ala Ala Ala Tyr Tyr Cys His Gln Ser Ser Arg 
            100                 105                 110         


Leu Pro His Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             


<210>  9
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ser Pro Ser Gln Leu Ile Gly Phe Leu Leu Leu Trp Val Pro Ala 
1               5                   10                  15      


Ser Arg Gly Glu Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ser Val 
            20                  25                  30          


Thr Pro Gly Glu Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile 
        35                  40                  45              


Gly Ser Ser Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys 
    50                  55                  60                  


Leu Leu Ile Lys Tyr Ala Ser Gln Ser Leu Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Glu Ala Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Ser Ser Arg 
            100                 105                 110         


Leu Pro His Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             


<210>  10
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Pro Ser Gln Leu Ile Gly Phe Leu Leu Leu Trp Val Pro Ala 
1               5                   10                  15      


Ser Arg Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Val 
            20                  25                  30          


Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile 
        35                  40                  45              


Gly Ser Ser Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    50                  55                  60                  


Leu Leu Ile Lys Tyr Ala Ser Gln Ser Leu Ser Gly Ile Pro Asp Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg 
                85                  90                  95      


Leu Glu Pro Glu Asp Ala Ala Ala Tyr Tyr Cys His Gln Ser Ser Arg 
            100                 105                 110         


Leu Pro His Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             


<210>  11
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ser Pro Ser Gln Leu Ile Gly Phe Leu Leu Leu Trp Val Pro Ala 
1               5                   10                  15      


Ser Arg Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Val 
            20                  25                  30          


Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile 
        35                  40                  45              


Gly Ser Ser Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    50                  55                  60                  


Leu Leu Ile Lys Tyr Ala Ser Gln Ser Leu Ser Gly Ile Pro Asp Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg 
                85                  90                  95      


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Ser Ser Arg 
            100                 105                 110         


Leu Pro His Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             


<210>  12
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Phe Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Ser Val Ile Asp Thr Arg Gly Ala Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Leu Gly Asn Phe Tyr Tyr Gly Met Asp Val Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135         


<210>  13
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Phe Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Ser Val Ile Asp Thr Arg Gly Ala Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Leu Gly Asn Phe Tyr Tyr Gly Met Asp Val Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135         


<210>  14
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Glu Leu Gly Leu Ser Trp Ile Phe Leu Leu Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Gly Ile Ser Trp Asn Ser Gly Ser Lys Gly Tyr Val 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Asp Ile Arg Ile Gly Val Ala Ala Ser Tyr Tyr 
        115                 120                 125             


Phe Gly Met Asp Val Trp Gly His Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140                 


<210>  15
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  15

Gly Phe Thr Phe Asp Asp Tyr Ala Met His 
1               5                   10  


<210>  16
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  16

Gly Ile Ser Trp Asn Ser Gly Ser Lys Gly Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  17
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  17

Asp Ile Arg Ile Gly Val Ala Ala Ser Tyr Tyr Phe Gly Met Asp Val 
1               5                   10                  15      


<210>  18
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Gly Ile Ser Ser Val Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Phe Asn Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys 
    


<210>  19
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  19

Arg Ala Ser Gln Gly Ile Ser Ser Val Leu Ala 
1               5                   10      


<210>  20
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  20

Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  21
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  21

Gln Gln Phe Asn Ser Tyr Pro Tyr Thr 
1               5                   


<210>  22
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Val Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu 
    50                  55                  60                  


Glu Trp Met Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser 
                85                  90                  95      


Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Gly Met Pro Val Ala Gly Pro Gly Tyr Phe 
        115                 120                 125             


Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser 
145     


<210>  23
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  23

Gly Tyr Thr Phe Thr Ser Tyr Val Met His 
1               5                   10  


<210>  24
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  24

Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  25
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  25

Gly Gly Met Pro Val Ala Gly Pro Gly Tyr Phe Tyr Tyr Tyr Gly Met 
1               5                   10                  15      


Asp Val 
        


<210>  26
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Arg Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Cys Cys Gln Gln Tyr 
            100                 105                 110         


Gly Ser Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr 
    130 


<210>  27
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  27

Arg Ala Ser Gln Ser Val Ser Arg Ser Tyr Leu Ala 
1               5                   10          


<210>  28
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  28

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  29
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  29

Gln Gln Tyr Gly Ser Ser Pro Trp Thr 
1               5                   


<210>  30
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  30

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Thr Thr Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Leu Gly Trp Ser Asp Ser Tyr Tyr Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  31
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  31

Asp Ile Gln Met Thr Gln Phe Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Arg Leu His Arg Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Cys 
                85                  90                  95      


Ser Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  32
<211>  4699
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pUIGFRLCB2 plasmid sequence

<400>  32
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtgttgttc cagtttggaa caagagtcca ctattaaaga acgtggactc      180

caacgtcaaa gggcgaaaaa ccgtctatca gggcgatggc ccactacgtg aaccatcacc      240

ctaatcaagt tttttggggt cgaggtgccg taaagcacta aatcggaacc ctaaagggag      300

cccccgattt agagcttgac ggggaaagcc ggcgaacgtg gcgagaaagg aagggaagaa      360

agcgaaagga gcgggcgcta gggcgctggc aagtgtagcg gtcacgctgc gcgtaaccac      420

cacacccgcc gcgcttaatg cgccgctaca gggcgcgtcc cattcgccat tcaggctgcg      480

caactgttgg gaagggcgat cggtgcgggc ctcttcgcta ttacgccagc tggcgaaagg      540

gggatgtgct gcaaggcgat taagttgggt aacgccaggg ttttcccagt cacgacgttg      600

taaaacgacg gccagtgagc gcgccaccgg tggcccgggc cggtccgact agttaccgat      660

gtacgggcca gatatacgcg ttgacattga ttattgacta gttattaata gtaatcaatt      720

acggggtcat tagttcatag cccatatatg gagttccgcg ttacataact tacggtaaat      780

ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaataat gacgtatgtt      840

cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta tttacggtaa      900

actgcccact tggcagtaca tcaagtgtat catatgccaa gtacgccccc tattgacgtc      960

aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttatg ggactttcct     1020

acttggcagt acatctacgt attagtcatc gctattacca tggtgatgcg gttttggcag     1080

tacatcaatg ggcgtggata gcggtttgac tcacggggat ttccaagtct ccaccccatt     1140

gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg actttccaaa atgtcgtaac     1200

aactccgccc cattgacgca aatgggcggt aggcgtgtac ggtgggaggt ctatataagc     1260

agagctctct ggctaactag agaacccact gcttactggc ttatcgaaat taatacgact     1320

cactatagca attgcacgtg tggccacagg taagtttaaa gctcaggtcg agaccgggcc     1380

tttgtccggc gctcccttgg agcctaccta gactcagccg gctctccacg ctttgcctga     1440

ccctgcttgc tcaactctac gtctttgttt cgttttctgt tcctttctct ccacaggctt     1500

aagaattcta gcgtttaaca tgtcgccatc acaactcatt gggtttctgc tgctctgggt     1560

tccagcctcc aggggtgaaa ttgtgctgac tcagagccca ggtaccctgt ctgtgtctcc     1620

aggcgagaga gccaccctct cctgccgggc cagtcagagc attggtagta gcttacactg     1680

gtaccagcag aaaccaggtc aggctccaag gcttctcatc aagtatgcat cccagtccct     1740

ctcagggatc cccgataggt tcagtggcag tggatctggg acagatttca ccctcaccat     1800

cagtagactg gagcctgaag atttcgcagt gtattactgt catcagagta gtcgtttacc     1860

tcacactttc ggccaaggga ccaaggtgga gatcaaacgt acagtggctg caccatctgt     1920

cttcatcttc ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct     1980

gctgaataac ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca     2040

atcgggtaac tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct     2100

cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga     2160

agtcacccat cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgtta     2220

gagggagaag gggccctccg gaggatccag atccccctcg ctttcttgct gtccaatttc     2280

tattaaaggt tcctttgttc cctaagtcca actactaaac tgggggatat tatgaagggc     2340

cttgagcatc tggattctgc ctaataaaaa acatttattt tcattgcaat gatgtattta     2400

aattatttct gaatatttta ctaaaaaggg aatgtgggag gtcagtgcat ttaaaacata     2460

aagaaatgaa gagggggatc tgtcgacaag ctctagagag ctccatatgt ggccatcgcg     2520

attaattaag cgcgcttggc gtaatcatgg tcatagctgt ttcctgtgtg aaattgttat     2580

ccgctcacaa ttccacacaa catacgagcc ggaagcataa agtgtaaagc ctggggtgcc     2640

taatgagtga gctaactcac attaattgcg ttgcgctcac tgcccgcttt ccagtcggga     2700

aacctgtcgt gccagctgca ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt     2760

attgggcgct cttccgcttc ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg     2820

cgagcggtat cagctcactc aaaggcggta atacggttat ccacagaatc aggggataac     2880

gcaggaaaga acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg     2940

ttgctggcgt ttttccatag gctccgcccc cctgacgagc atcacaaaaa tcgacgctca     3000

agtcagaggt ggcgaaaccc gacaggacta taaagatacc aggcgtttcc ccctggaagc     3060

tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg gatacctgtc cgcctttctc     3120

ccttcgggaa gcgtggcgct ttctcatagc tcacgctgta ggtatctcag ttcggtgtag     3180

gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc     3240

ttatccggta actatcgtct tgagtccaac ccggtaagac acgacttatc gccactggca     3300

gcagccactg gtaacaggat tagcagagcg aggtatgtag gcggtgctac agagttcttg     3360

aagtggtggc ctaactacgg ctacactaga aggacagtat ttggtatctg cgctctgctg     3420

aagccagtta ccttcggaaa aagagttggt agctcttgat ccggcaaaca aaccaccgct     3480

ggtagcggtg gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa     3540

gaagatcctt tgatcttttc tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa     3600

gggattttgg tcatgagatt atcaaaaagg atcttcacct agatcctttt aaattaaaaa     3660

tgaagtttta aatcaatcta aagtatatat gagtaaactt ggtctgacag ttaccaatgc     3720

ttaatcagtg aggcacctat ctcagcgatc tgtctatttc gttcatccat agttgcctga     3780

ctccccgtcg tgtagataac tacgatacgg gagggcttac catctggccc cagtgctgca     3840

atgataccgc gagacccacg ctcaccggct ccagatttat cagcaataaa ccagccagcc     3900

ggaagggccg agcgcagaag tggtcctgca actttatccg cctccatcca gtctattaat     3960

tgttgccggg aagctagagt aagtagttcg ccagttaata gtttgcgcaa cgttgttgcc     4020

attgctacag gcatcgtggt gtcacgctcg tcgtttggta tggcttcatt cagctccggt     4080

tcccaacgat caaggcgagt tacatgatcc cccatgttgt gcaaaaaagc ggttagctcc     4140

ttcggtcctc cgatcgttgt cagaagtaag ttggccgcag tgttatcact catggttatg     4200

gcagcactgc ataattctct tactgtcatg ccatccgtaa gatgcttttc tgtgactggt     4260

gagtactcaa ccaagtcatt ctgagaatag tgtatgcggc gaccgagttg ctcttgcccg     4320

gcgtcaatac gggataatac cgcgccacat agcagaactt taaaagtgct catcattgga     4380

aaacgttctt cggggcgaaa actctcaagg atcttaccgc tgttgagatc cagttcgatg     4440

taacccactc gtgcacccaa ctgatcttca gcatctttta ctttcaccag cgtttctggg     4500

tgagcaaaaa caggaaggca aaatgccgca aaaaagggaa taagggcgac acggaaatgt     4560

tgaatactca tactcttcct ttttcaatat tattgaagca tttatcaggg ttattgtctc     4620

atgagcggat acatatttga atgtatttag aaaaataaac aaataggggt tccgcgcaca     4680

tttccccgaa aagtgccac                                                  4699


<210>  33
<211>  7439
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pUIG1FRmodH plasmid sequence

<400>  33
tataaatcaa aagaatagac cgagataggg ttgagtgttg ttccagtttg gaacaagagt       60

ccactattaa agaacgtgga ctccaacgtc aaagggcgaa aaaccgtcta tcagggcgat      120

ggcccactac gtgaaccatc accctaatca agttttttgg ggtcgaggtg ccgtaaagca      180

ctaaatcgga accctaaagg gagcccccga tttagagctt gacggggaaa gccggcgaac      240

gtggcgagaa aggaagggaa gaaagcgaaa ggagcgggcg ctagggcgct ggcaagtgta      300

gcggtcacgc tgcgcgtaac caccacaccc gccgcgctta atgcgccgct acagggcgcg      360

tcccattcgc cattcaggct gcgcaactgt tgggaagggc gatcggtgcg ggcctcttcg      420

ctattacgcc agctggcgaa agggggatgt gctgcaaggc gattaagttg ggtaacgcca      480

gggttttccc agtcacgacg ttgtaaaacg acggccagtg agcgcgccgt ttaaaccctc      540

agctaccgat gtacgggcca gatatacgcg ttgacattga ttattgacta gttattaata      600

gtaatcaatt acggggtcat tagttcatag cccatatatg gagttccgcg ttacataact      660

tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaataat      720

gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta      780

tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa gtacgccccc      840

tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttatg      900

ggactttcct acttggcagt acatctacgt attagtcatc gctattacca tggtgatgcg      960

gttttggcag tacatcaatg ggcgtggata gcggtttgac tcacggggat ttccaagtct     1020

ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg actttccaaa     1080

atgtcgtaac aactccgccc cattgacgca aatgggcggt aggcgtgtac ggtgggaggt     1140

ctatataagc agagctctct ggctaactag agaacccact gcttactggc ttatcgaaat     1200

taatacgact cactatagca attgcacgtg tggccacagg taagtttaaa gctcaggtcg     1260

agaccgggcc tttgtccggc gctcccttgg agcctaccta gactcagccg gctctccacg     1320

ctttgcctga ccctgcttgc tcaactctac gtctttgttt cgttttctgt tcctttctct     1380

ccacaggctt aagcttggta ccgagctcgg atccactagt ccagtgtggt ggaattcgcc     1440

cttatggagt ttgggctgag ctgggttttc cttgttgcta tattaaaagg tgtccagtgt     1500

gaggttcagc tggtgcagtc tgggggaggc ttggtaaagc ctggggggtc cctgagactc     1560

tcctgtgcag cctctggatt caccttcagt agctttgcta tgcactgggt tcgccaggct     1620

ccaggaaaag gtctggagtg gatatcagtt attgatactc gtggtgccac atactatgca     1680

gactccgtga agggccgatt caccatctcc agagacaatg ccaagaactc cttgtatctt     1740

caaatgaaca gcctgagagc cgaggacact gctgtgtatt actgtgcaag actggggaac     1800

ttctactacg gtatggacgt ctggggccaa gggaccacgg tcaccgtctc ctcagcttcc     1860

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca     1920

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac     1980

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc     2040

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc     2100

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct     2160

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca     2220

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     2280

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     2340

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     2400

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     2460

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc     2520

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc     2580

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     2640

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     2700

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     2760

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     2820

agcctctccc tgtctccggg taaatgaatc gatgattcta gatacgggtc cggaggatcc     2880

agatccccct cgctttcttg ctgtccaatt tctattaaag gttcctttgt tccctaagtc     2940

caactactaa actgggggat attatgaagg gccttgagca tctggattct gcctaataaa     3000

aaacatttat tttcattgca atgatgtatt taaattattt ctgaatattt tactaaaaag     3060

ggaatgtggg aggtcagtgc atttaaaaca taaagaaatg aagaggggga tctgtcgaca     3120

agctctagag agctcacgcg ttgatcatgt acaggccggc caagctttcg actagcttgg     3180

cacgccagaa atccgcgcgg tggtttttgg gggtcggggg tgtttggcag ccacagacgc     3240

ccggtgttcg tgtcgcgcca gtacatgcgg tccatgccca ggccatccaa aaaccatggg     3300

tctgtctgct cagtccagtc gtggacctga ccccacgcaa cgcccaaaat aataaccccc     3360

acgaaccata aaccattccc catgggggac cccgtcccta acccacgggg ccagtggcta     3420

tggcagggcc tgccgccccg acgttggctg cgagccctgg gccttcaccc gaacttgggg     3480

ggtggggtgg ggaaaaggaa gaaacgcggg cgtattggcc ccaatggggt ctcggtgggg     3540

tatcgacaga gtgccagccc tgggaccgaa ccccgcgttt atgaacaaac gacccaacac     3600

ccgtgcgttt tattctgtct ttttattgcc gtcatagcgc gggttccttc cggtattgtc     3660

tccttccgtg tttcagttag cctcccccat ctcccgatcc ggacgagtgc tggggcgtcg     3720

gtttccacta tcggcgagta cttctacaca gccatcggtc cagacggccg cgcttctgcg     3780

ggcgatttgt gtacgcccga cagtcccggc tccggatcgg acgattgcgt cgcatcgacc     3840

ctgcgcccaa gctgcatcat cgaaattgcc gtcaaccaag ctctgataga gttggtcaag     3900

accaatgcgg agcatatacg cccggagccg cggcgatcct gcaagctccg gatgcctccg     3960

ctcgaagtag cgcgtctgct gctccataca agccaaccac ggcctccaga agaagatgtt     4020

ggcgacctcg tattgggaat ccccgaacat cgcctcgctc cagtcaatga ccgctgttat     4080

gcggccattg tccgtcagga cattgttgga gccgaaatcc gcgtgcacga ggtgccggac     4140

ttcggggcag tcctcggccc aaagcatcag ctcatcgaga gcctgcgcga cggacgcact     4200

gacggtgtcg tccatcacag tttgccagtg atacacatgg ggatcagcaa tcgcgcatat     4260

gaaatcacgc catgtagtgt attgaccgat tccttgcggt ccgaatgggc cgaacccgct     4320

cgtctggcta agatcggccg cagcgatcgc atccatggcc tccgcgaccg gctgcagaac     4380

agcgggcagt tcggtttcag gcaggtcttg caacgtgaca ccctgtgcac ggcgggagat     4440

gcaataggtc aggctctcgc tgaattcccc aatgtcaagc acttccggaa tcgggagcgc     4500

ggccgatgca aagtgccgat aaacataacg atctttgtag aaaccatcgg cgcagctatt     4560

tacccgcagg acatatccac gccctcctac atcgaagctg aaagcacgag attcttcgcc     4620

ctccgagagc tgcatcaggt cggagacgct gtcgaacttt tcgatcagaa acttctcgac     4680

agacgtcgcg gtgagttcag gctttttcat atctcattgc cccccgggat ctgcggcacg     4740

ctgttgacgc tgttaagcgg gtcgctgcag ggtcgctcgg tgttcgaggc cacacgcgtc     4800

accttaatat gcgaagtgga cctcggaccg cgccgccccg actgcatctg cgtgttcgaa     4860

ttcgccaatg acaagacgct gggcggggtt tgtgtcatca tagaactaaa gacatgcaaa     4920

tatatttctt ccggggacac cgccagcaaa cgcgagcaac gggccacggg gatgaagcag     4980

ggcggcacct cgctaacgga ttcaccactc caagaattgg agccaatcaa ttcttgcgga     5040

gaactgtgaa tgcgcaaacc aacccttggc agaacatatc catcgcgtcc gccatctcca     5100

gcagccgcac gcggcgcatc tcggggccga cgcgctgggc tacgtcttgc tggcgttcgc     5160

acaggccggc cagcgcgctt ggcgtaatca tggtcatagc tgtttcctgt gtgaaattgt     5220

tatccgctca caattccaca caacatacga gccggaagca taaagtgtaa agcctggggt     5280

gcctaatgag tgagctaact cacattaatt gcgttgcgct cactgcccgc tttccagtcg     5340

ggaaacctgt cgtgccagct gcattaatga atcggccaac gcgcggggag aggcggtttg     5400

cgtattgggc gctcttccgc ttcctcgctc actgactcgc tgcgctcggt cgttcggctg     5460

cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt tatccacaga atcaggggat     5520

aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc     5580

gcgttgctgg cgtttttcca taggctccgc ccccctgacg agcatcacaa aaatcgacgc     5640

tcaagtcaga ggtggcgaaa cccgacagga ctataaagat accaggcgtt tccccctgga     5700

agctccctcg tgcgctctcc tgttccgacc ctgccgctta ccggatacct gtccgccttt     5760

ctcccttcgg gaagcgtggc gctttctcat agctcacgct gtaggtatct cagttcggtg     5820

taggtcgttc gctccaagct gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc     5880

gccttatccg gtaactatcg tcttgagtcc aacccggtaa gacacgactt atcgccactg     5940

gcagcagcca ctggtaacag gattagcaga gcgaggtatg taggcggtgc tacagagttc     6000

ttgaagtggt ggcctaacta cggctacact agaaggacag tatttggtat ctgcgctctg     6060

ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa acaaaccacc     6120

gctggtagcg gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct     6180

caagaagatc ctttgatctt ttctacgggg tctgacgctc agtggaacga aaactcacgt     6240

taagggattt tggtcatgag attatcaaaa aggatcttca cctagatcct tttaaattaa     6300

aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa cttggtctga cagttaccaa     6360

tgcttaatca gtgaggcacc tatctcagcg atctgtctat ttcgttcatc catagttgcc     6420

tgactccccg tcgtgtagat aactacgata cgggagggct taccatctgg ccccagtgct     6480

gcaatgatac cgcgagaccc acgctcaccg gctccagatt tatcagcaat aaaccagcca     6540

gccggaaggg ccgagcgcag aagtggtcct gcaactttat ccgcctccat ccagtctatt     6600

aattgttgcc gggaagctag agtaagtagt tcgccagtta atagtttgcg caacgttgtt     6660

gccattgcta caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc     6720

ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa agcggttagc     6780

tccttcggtc ctccgatcgt tgtcagaagt aagttggccg cagtgttatc actcatggtt     6840

atggcagcac tgcataattc tcttactgtc atgccatccg taagatgctt ttctgtgact     6900

ggtgagtact caaccaagtc attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc     6960

ccggcgtcaa tacgggataa taccgcgcca catagcagaa ctttaaaagt gctcatcatt     7020

ggaaaacgtt cttcggggcg aaaactctca aggatcttac cgctgttgag atccagttcg     7080

atgtaaccca ctcgtgcacc caactgatct tcagcatctt ttactttcac cagcgtttct     7140

gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa     7200

tgttgaatac tcatactctt cctttttcaa tattattgaa gcatttatca gggttattgt     7260

ctcatgagcg gatacatatt tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc     7320

acatttcccc gaaaagtgcc acctaaattg taagcgttaa tattttgtta aaattcgcgt     7380

taaatttttg ttaaatcagc tcatttttta accaataggc cgaaatcggc aaaatccct      7439


<210>  34
<211>  7318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAIGFRLCb2 plasmid sequence

<400>  34
gcactataca tcaaatattc cttattaacc cctttacaaa ttaaaaagct aaaggtacac       60

aatttttgag catagttatt aatagcagac actctatgcc tgtgtggagt aagaaaaaac      120

agtatgttat gattataact gttatgccta cttataaagg ttacagaata tttttccata      180

attttcttgt atagcagtgc agctttttcc tttgtggtgt aaatagcaaa gcaagcaaga      240

gttctattac taaacacagc atgactcaaa aaacttagca attctgaagg aaagtccttg      300

gggtcttcta cctttctctt cttttttgga ggagtagaat gttgagagtc agcagtagcc      360

tcatcatcac tagatggcat ttcttctgag caaaacaggt tttcctcatt aaaggcattc      420

caccactgct cccattcatc agttccatag gttggaatct aaaatacaca aacaattaga      480

atcagtagtt taacacatta tacacttaaa aattttatat ttaccttaga gctttaaatc      540

tctgtaggta gtttgtccaa ttatgtcaca ccacagaagt aaggttcctt cacaaagatc      600

gatctaaagc cagcaaaagt cccatggtct tataaaaatg catagcttta ggaggggagc      660

agagaacttg aaagcatctt cctgttagtc tttcttctcg tagacttcaa acttatactt      720

gatgcctttt tcctcctgga cctcagagag gacgcctggg tattctggga gaagtttata      780

tttccccaaa tcaatttctg ggaaaaacgt gtcactttca aattcctgca tgatccttgt      840

cacaaagagt ctgaggtggc ctggttgatt catggcttcc tggtaaacag aactgcctcc      900

gactatccaa accatgtcta ctttacttgc caattccggt tgttcaataa gtcttaaggc      960

atcatccaaa cttttggcaa gaaaatgagc tcctcgtggt ggttctttga gttctctact     1020

gagaactata ttaattctgt cctttaaagg tcgattcttc tcaggaatgg agaaccaggt     1080

tttcctaccc ataatcacca gattctgttt accttccact gaagaggttg tggtcattct     1140

ttggaagtac ttgaactcgt tcctgagcgg aggccagggt aggtctccgt tcttgccaat     1200

ccccatattt tgggacacgg cgacgatgca gttcaatggt cgaaccatga tggcagcggg     1260

gataaaatcc taccagcctt cacgctagga ttgccgtcaa gtttggcgcg aaatcgcagc     1320

cctgagctgt cccccccccc aagctcagat ctgagcttgg tccctatggt gagtccgttc     1380

cgctcttgtg atgatagcca gacaagaaag agacaataca agacaaacac caaatagtag     1440

aaatagagac aagggtcact tatccgaggg tccctgttcg ggcgccagct gccgcagtcg     1500

gccgacctga gggtcgccgg ggtctgcggg gggaccctct ggaaagtgaa ggataagtga     1560

cgagcggaga cgggatggcg aacagacaca aacacacaag aggtgaatgt taggactgtt     1620

gcaagtttac tcaaaaaatc agcactcttt tatatcttgg tttacataag catttacata     1680

agatttggat aaattccaaa agaacatagg aaaatagaac actcagagct cagatcagaa     1740

cctttgatac caaaccaagt caggaaacca cttgtctcac atcctcgttt taagaacagt     1800

ttgtaaccaa aaacttactt aagccctggg aaccgcaagg ttgggccaat aaaggctatt     1860

cataataact catgccatga gtttttgcag aataatgttc tattagtcca gccactgtcc     1920

cctccttggt atggaaaatc tttccccaaa agtgcattcc tgttcctaga taaatataat     1980

catgtacctg ttgtttcatg tcgtcttttt cttcttgaga caacatacac caaggaggtc     2040

tagctctggc gagtctttca cgaaaaggga gggatctata taacacttta tagccattga     2100

ctgtaaccca cctatcccaa tttaagtcat atcttcctgt atatggtaag ggggcatctg     2160

ttggtctgta gatgtaaggt cccctataag tccctggttg ccaccacctg tctcctattt     2220

tgacaaaaac actctttttt ccctttttta cttctaggcc tgtggtcaat agtccttgca     2280

cctgttcttc aattgaggtt gagcgtctct ttctattttc tattcccatt tctaacttct     2340

gaatttgagt aaaaatagta ctaaaagata atgattcatt tcttaacata gtaactaata     2400

atctacctat tggattggtc ttattggtaa aaatataatt tttagcaagc attcttattt     2460

ctatttctga aggacaaaat cgatgcggct tgtaagagga agttggctgt ggtccttgcc     2520

tcaggaggaa ggtcgagttc tccgaattgt ttagattgta atcttgcaca gaagagctat     2580

taaaagagtc aagggtgaga gccctgcgag cacgaaccgc aacttccccc aatagcccca     2640

ggcaaagcag agctatgcca agtttgcagc agagaatgaa tatgtctttg tctgatgggc     2700

tcatccgttt gtgcgcagac gggtcgtcct tggtgggaaa caaccccttg gctgcttctc     2760

ccctaggtgt aggacactct cgggagttca accatttctg cccaagctca gatctgagct     2820

ttaatgcggt agtttatcac agttaaattg ctaacgcagt caggcaccgt gtatgaaatc     2880

taacaatgcg ctcatcgtca tcctcggcac cgtcaccctg gatgctgtag gcataggctt     2940

ggttatgccg gtactgccgg gcctcttgcg ggatatcgtc cattccgaca gcatcgccag     3000

tcactatggc gtgctgctag cgctcttccg cttcctcgct cactgactcg ctgcgctcgg     3060

tcgttcggct gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag     3120

aatcagggga taacgcagga aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc     3180

gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca     3240

aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt     3300

ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc     3360

tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc     3420

tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc     3480

ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact     3540

tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg     3600

ctacagagtt cttgaagtgg tggcctaact acggctacac tagaaggaca gtatttggta     3660

tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca     3720

aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa     3780

aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct cagtggaacg     3840

aaaactcacg ttaagggatt ttggtcatga gattatcaaa aaggatcttc acctagatcc     3900

ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa acttggtctg     3960

acagttacca atgcttaatc agtgaggcac ctatctcagc gatctgtcta tttcgttcat     4020

ccatagttgc ctgactcccc gtcgtgtaga taactacgat acgggagggc ttaccatctg     4080

gccccagtgc tgcaatgata ccgcgagacc cacgctcacc ggctccagat ttatcagcaa     4140

taaaccagcc agccggaagg gccgagcgca gaagtggtcc tgcaacttta tccgcctcca     4200

tccagtctat taattgttgc cgggaagcta gagtaagtag ttcgccagtt aatagtttgc     4260

gcaacgttgt tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt     4320

cattcagctc cggttcccaa cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa     4380

aagcggttag ctccttcggt cctccgatcg ttgtcagaag taagttggcc gcagtgttat     4440

cactcatggt tatggcagca ctgcataatt ctcttactgt catgccatcc gtaagatgct     4500

tttctgtgac tggtgagtac tcaaccaagt cattctgaga atagtgtatg cggcgaccga     4560

gttgctcttg cccggcgtca acacgggata ataccgcgcc acatagcaga actttaaaag     4620

tgctcatcat tggaaaacgt tcttcggggc gaaaactctc aaggatctta ccgctgttga     4680

gatccagttc gatgtaaccc actcgtgcac ccaactgatc ttcagcatct tttactttca     4740

ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg     4800

cgacacggaa atgttgaata ctcatactct tcctttttca atattattga agcatttatc     4860

agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat aaacaaatag     4920

gggttccgcg cacatttccc cgaaaagtgc cacctgacgt ctaagagacc attattatca     4980

tgacattaac ctataaaaat aggcgtatca cgaggccctt tcgtcttcaa gaattgtcta     5040

gaggcgcgcc gtttaaaccc tcagctgatc atccggatgt acagcgcgcg gccggccggt     5100

accacgcgtt ggccacatat ggcggccgct cgcgattaat taatcgcgat ggccacatat     5160

ggagctctct agagcttgtc gacagatccc cctcttcatt tctttatgtt ttaaatgcac     5220

tgacctccca cattcccttt ttagtaaaat attcagaaat aatttaaata catcattgca     5280

atgaaaataa atgtttttta ttaggcagaa tccagatgct caaggccctt cataatatcc     5340

cccagtttag tagttggact tagggaacaa aggaaccttt aatagaaatt ggacagcaag     5400

aaagcgaggg ggatctggat cctccggagg gccccttctc cctctaacac tctcccctgt     5460

tgaagctctt tgtgacgggc gagctcaggc cctgatgggt gacttcgcag gcgtagactt     5520

tgtgtttctc gtagtctgct ttgctcagcg tcagggtgct gctgaggctg taggtgctgt     5580

ccttgctgtc ctgctctgtg acactctcct gggagttacc cgattggagg gcgttatcca     5640

ccttccactg tactttggcc tctctgggat agaagttatt cagcaggcac acaacagagg     5700

cagttccaga tttcaactgc tcatcagatg gcgggaagat gaagacagat ggtgcagcca     5760

ctgtacgttt gatctccacc ttggtccctt ggccgaaagt gtgaggtaaa cgactactct     5820

gatgacagta atacactgcg aaatcttcag gctccagtct actgatggtg agggtgaaat     5880

ctgtcccaga tccactgcca ctgaacctat cggggatccc tgagagggac tgggatgcat     5940

acttgatgag aagccttgga gcctgacctg gtttctgctg gtaccagtgt aagctactac     6000

caatgctctg actggcccgg caggagaggg tggctctctc gcctggagac acagacaggg     6060

tacctgggct ctgagtcagc acaatttcac ccctggaggc tggaacccag agcagcagaa     6120

acccaatgag ttgtgatggc gacatgttaa acgctagaat tcttaagcct gtggagagaa     6180

aggaacagaa aacgaaacaa agacgtagag ttgagcaagc agggtcaggc aaagcgtgga     6240

gagccggctg agtctaggta ggctccaagg gagcgccgga caaaggcccg gtctcgacct     6300

gagctttaaa cttacctgtg gccacacgtg caattgctat agtgagtcgt attaatttcg     6360

ataagccagt aagcagtggg ttctctagtt agccagagag ctctgcttat atagacctcc     6420

caccgtacac gcctaccgcc catttgcgtc aatggggcgg agttgttacg acattttgga     6480

aagtcccgtt gattttggtg ccaaaacaaa ctcccattga cgtcaatggg gtggagactt     6540

ggaaatcccc gtgagtcaaa ccgctatcca cgcccattga tgtactgcca aaaccgcatc     6600

accatggtaa tagcgatgac taatacgtag atgtactgcc aagtaggaaa gtcccataag     6660

gtcatgtact gggcataatg ccaggcgggc catttaccgt cattgacgtc aatagggggc     6720

gtacttggca tatgatacac ttgatgtact gccaagtggg cagtttaccg taaatactcc     6780

acccattgac gtcaatggaa agtccctatt ggcgttacta tgggaacata cgtcattatt     6840

gacgtcaatg ggcgggggtc gttgggcggt cagccaggcg ggccatttac cgtaagttat     6900

gtaacgcgga actccatata tgggctatga actaatgacc ccgtaattga ttactattaa     6960

taactagtca ataatcaatg tcaacgcgta tatctggccc gtacatcggt aactagtcgg     7020

accgccgcgg actagtgccc gggccaccgg tgctcgaagc ttggatcgat ccagacatga     7080

taagatacat tgatgagttt ggacaaacca caactagaat gcagtgaaaa aaatgcttta     7140

tttgtgaaat ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag     7200

ttaacaacaa caattgcatt cattttatgt ttcaggttca gggggaggtg tgggaggttt     7260

tttaaagcaa gtaaaacctc tacaaatgtg gtatggctga ttatgatctc tagtcaag       7318


<210>  35
<211>  11928
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAIG1FRLCb2V1 plasmid sequence

<400>  35
gcactataca tcaaatattc cttattaacc cctttacaaa ttaaaaagct aaaggtacac       60

aatttttgag catagttatt aatagcagac actctatgcc tgtgtggagt aagaaaaaac      120

agtatgttat gattataact gttatgccta cttataaagg ttacagaata tttttccata      180

attttcttgt atagcagtgc agctttttcc tttgtggtgt aaatagcaaa gcaagcaaga      240

gttctattac taaacacagc atgactcaaa aaacttagca attctgaagg aaagtccttg      300

gggtcttcta cctttctctt cttttttgga ggagtagaat gttgagagtc agcagtagcc      360

tcatcatcac tagatggcat ttcttctgag caaaacaggt tttcctcatt aaaggcattc      420

caccactgct cccattcatc agttccatag gttggaatct aaaatacaca aacaattaga      480

atcagtagtt taacacatta tacacttaaa aattttatat ttaccttaga gctttaaatc      540

tctgtaggta gtttgtccaa ttatgtcaca ccacagaagt aaggttcctt cacaaagatc      600

gatctaaagc cagcaaaagt cccatggtct tataaaaatg catagcttta ggaggggagc      660

agagaacttg aaagcatctt cctgttagtc tttcttctcg tagacttcaa acttatactt      720

gatgcctttt tcctcctgga cctcagagag gacgcctggg tattctggga gaagtttata      780

tttccccaaa tcaatttctg ggaaaaacgt gtcactttca aattcctgca tgatccttgt      840

cacaaagagt ctgaggtggc ctggttgatt catggcttcc tggtaaacag aactgcctcc      900

gactatccaa accatgtcta ctttacttgc caattccggt tgttcaataa gtcttaaggc      960

atcatccaaa cttttggcaa gaaaatgagc tcctcgtggt ggttctttga gttctctact     1020

gagaactata ttaattctgt cctttaaagg tcgattcttc tcaggaatgg agaaccaggt     1080

tttcctaccc ataatcacca gattctgttt accttccact gaagaggttg tggtcattct     1140

ttggaagtac ttgaactcgt tcctgagcgg aggccagggt aggtctccgt tcttgccaat     1200

ccccatattt tgggacacgg cgacgatgca gttcaatggt cgaaccatga tggcagcggg     1260

gataaaatcc taccagcctt cacgctagga ttgccgtcaa gtttggcgcg aaatcgcagc     1320

cctgagctgt cccccccccc aagctcagat ctgagcttgg tccctatggt gagtccgttc     1380

cgctcttgtg atgatagcca gacaagaaag agacaataca agacaaacac caaatagtag     1440

aaatagagac aagggtcact tatccgaggg tccctgttcg ggcgccagct gccgcagtcg     1500

gccgacctga gggtcgccgg ggtctgcggg gggaccctct ggaaagtgaa ggataagtga     1560

cgagcggaga cgggatggcg aacagacaca aacacacaag aggtgaatgt taggactgtt     1620

gcaagtttac tcaaaaaatc agcactcttt tatatcttgg tttacataag catttacata     1680

agatttggat aaattccaaa agaacatagg aaaatagaac actcagagct cagatcagaa     1740

cctttgatac caaaccaagt caggaaacca cttgtctcac atcctcgttt taagaacagt     1800

ttgtaaccaa aaacttactt aagccctggg aaccgcaagg ttgggccaat aaaggctatt     1860

cataataact catgccatga gtttttgcag aataatgttc tattagtcca gccactgtcc     1920

cctccttggt atggaaaatc tttccccaaa agtgcattcc tgttcctaga taaatataat     1980

catgtacctg ttgtttcatg tcgtcttttt cttcttgaga caacatacac caaggaggtc     2040

tagctctggc gagtctttca cgaaaaggga gggatctata taacacttta tagccattga     2100

ctgtaaccca cctatcccaa tttaagtcat atcttcctgt atatggtaag ggggcatctg     2160

ttggtctgta gatgtaaggt cccctataag tccctggttg ccaccacctg tctcctattt     2220

tgacaaaaac actctttttt ccctttttta cttctaggcc tgtggtcaat agtccttgca     2280

cctgttcttc aattgaggtt gagcgtctct ttctattttc tattcccatt tctaacttct     2340

gaatttgagt aaaaatagta ctaaaagata atgattcatt tcttaacata gtaactaata     2400

atctacctat tggattggtc ttattggtaa aaatataatt tttagcaagc attcttattt     2460

ctatttctga aggacaaaat cgatgcggct tgtaagagga agttggctgt ggtccttgcc     2520

tcaggaggaa ggtcgagttc tccgaattgt ttagattgta atcttgcaca gaagagctat     2580

taaaagagtc aagggtgaga gccctgcgag cacgaaccgc aacttccccc aatagcccca     2640

ggcaaagcag agctatgcca agtttgcagc agagaatgaa tatgtctttg tctgatgggc     2700

tcatccgttt gtgcgcagac gggtcgtcct tggtgggaaa caaccccttg gctgcttctc     2760

ccctaggtgt aggacactct cgggagttca accatttctg cccaagctca gatctgagct     2820

ttaatgcggt agtttatcac agttaaattg ctaacgcagt caggcaccgt gtatgaaatc     2880

taacaatgcg ctcatcgtca tcctcggcac cgtcaccctg gatgctgtag gcataggctt     2940

ggttatgccg gtactgccgg gcctcttgcg ggatatcgtc cattccgaca gcatcgccag     3000

tcactatggc gtgctgctag cgctcttccg cttcctcgct cactgactcg ctgcgctcgg     3060

tcgttcggct gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag     3120

aatcagggga taacgcagga aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc     3180

gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca     3240

aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt     3300

ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc     3360

tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc     3420

tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc     3480

ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact     3540

tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg     3600

ctacagagtt cttgaagtgg tggcctaact acggctacac tagaaggaca gtatttggta     3660

tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca     3720

aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa     3780

aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct cagtggaacg     3840

aaaactcacg ttaagggatt ttggtcatga gattatcaaa aaggatcttc acctagatcc     3900

ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa acttggtctg     3960

acagttacca atgcttaatc agtgaggcac ctatctcagc gatctgtcta tttcgttcat     4020

ccatagttgc ctgactcccc gtcgtgtaga taactacgat acgggagggc ttaccatctg     4080

gccccagtgc tgcaatgata ccgcgagacc cacgctcacc ggctccagat ttatcagcaa     4140

taaaccagcc agccggaagg gccgagcgca gaagtggtcc tgcaacttta tccgcctcca     4200

tccagtctat taattgttgc cgggaagcta gagtaagtag ttcgccagtt aatagtttgc     4260

gcaacgttgt tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt     4320

cattcagctc cggttcccaa cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa     4380

aagcggttag ctccttcggt cctccgatcg ttgtcagaag taagttggcc gcagtgttat     4440

cactcatggt tatggcagca ctgcataatt ctcttactgt catgccatcc gtaagatgct     4500

tttctgtgac tggtgagtac tcaaccaagt cattctgaga atagtgtatg cggcgaccga     4560

gttgctcttg cccggcgtca acacgggata ataccgcgcc acatagcaga actttaaaag     4620

tgctcatcat tggaaaacgt tcttcggggc gaaaactctc aaggatctta ccgctgttga     4680

gatccagttc gatgtaaccc actcgtgcac ccaactgatc ttcagcatct tttactttca     4740

ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg     4800

cgacacggaa atgttgaata ctcatactct tcctttttca atattattga agcatttatc     4860

agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat aaacaaatag     4920

gggttccgcg cacatttccc cgaaaagtgc cacctgacgt ctaagaaacc attattatca     4980

tgacattaac ctataaaaat aggcgtatca cgaggccctt tcgtcttcaa gaattgtcta     5040

gaggcgcgcc gtttaaaccc tcagctaccg atgtacgggc cagatatacg cgttgacatt     5100

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata     5160

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc     5220

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc     5280

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt     5340

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt     5400

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca     5460

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg     5520

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc     5580

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg     5640

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca     5700

ctgcttactg gcttatcgaa attaatacga ctcactatag caattgcacg tgtggccaca     5760

ggtaagttta aagctcaggt cgagaccggg cctttgtccg gcgctccctt ggagcctacc     5820

tagactcagc cggctctcca cgctttgcct gaccctgctt gctcaactct acgtctttgt     5880

ttcgttttct gttcctttct ctccacaggc ttaagcttgg taccgagctc ggatccacta     5940

gtccagtgtg gtggaattcg cccttatgga gtttgggctg agctgggttt tccttgttgc     6000

tatattaaaa ggtgtccagt gtgaggttca gctggtgcag tctgggggag gcttggtaaa     6060

gcctgggggg tccctgagac tctcctgtgc agcctctgga ttcaccttca gtagctttgc     6120

tatgcactgg gttcgccagg ctccaggaaa aggtctggag tggatatcag ttattgatac     6180

tcgtggtgcc acatactatg cagactccgt gaagggccga ttcaccatct ccagagacaa     6240

tgccaagaac tccttgtatc ttcaaatgaa cagcctgaga gccgaggaca ctgctgtgta     6300

ttactgtgca agactgggga acttctacta cggtatggac gtctggggcc aagggaccac     6360

ggtcaccgtc tcctcagctt ccaccaaggg cccatcggtc ttccccctgg caccctcctc     6420

caagagcacc tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga     6480

accggtgacg gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc     6540

tgtcctacag tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag     6600

cttgggcacc cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga     6660

caagaaagtt gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc     6720

tgaactcctg gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat     6780

gatctcccgg acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga     6840

ggtcaagttc aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg     6900

ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga     6960

ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat     7020

cgagaaaacc atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc     7080

cccatcccgg gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt     7140

ctatcccagc gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa     7200

gaccacgcct cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt     7260

ggacaagagc aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct     7320

gcacaaccac tacacgcaga agagcctctc cctgtctccg ggtaaatgaa tcgatgattc     7380

tagatacggg tccggaggat ccagatcccc ctcgctttct tgctgtccaa tttctattaa     7440

aggttccttt gttccctaag tccaactact aaactggggg atattatgaa gggccttgag     7500

catctggatt ctgcctaata aaaaacattt attttcattg caatgatgta tttaaattat     7560

ttctgaatat tttactaaaa agggaatgtg ggaggtcagt gcatttaaaa cataaagaaa     7620

tgaagagggg gatctgtcga caagctctag agagctcacg cgttgatcat gtacaggccg     7680

gccaagcttt cgactagctt ggcacgccag aaatccgcgc ggtggttttt gggggtcggg     7740

ggtgtttggc agccacagac gcccggtgtt cgtgtcgcgc cagtacatgc ggtccatgcc     7800

caggccatcc aaaaaccatg ggtctgtctg ctcagtccag tcgtggacct gaccccacgc     7860

aacgcccaaa ataataaccc ccacgaacca taaaccattc cccatggggg accccgtccc     7920

taacccacgg ggccagtggc tatggcaggg cctgccgccc cgacgttggc tgcgagccct     7980

gggccttcac ccgaacttgg ggggtggggt ggggaaaagg aagaaacgcg ggcgtattgg     8040

ccccaatggg gtctcggtgg ggtatcgaca gagtgccagc cctgggaccg aaccccgcgt     8100

ttatgaacaa acgacccaac acccgtgcgt tttattctgt ctttttattg ccgtcatagc     8160

gcgggttcct tccggtattg tctccttccg tgtttcagtt agcctccccc atctcccgat     8220

ccggacgagt gctggggcgt cggtttccac tatcggcgag tacttctaca cagccatcgg     8280

tccagacggc cgcgcttctg cgggcgattt gtgtacgccc gacagtcccg gctccggatc     8340

ggacgattgc gtcgcatcga ccctgcgccc aagctgcatc atcgaaattg ccgtcaacca     8400

agctctgata gagttggtca agaccaatgc ggagcatata cgcccggagc cgcggcgatc     8460

ctgcaagctc cggatgcctc cgctcgaagt agcgcgtctg ctgctccata caagccaacc     8520

acggcctcca gaagaagatg ttggcgacct cgtattggga atccccgaac atcgcctcgc     8580

tccagtcaat gaccgctgtt atgcggccat tgtccgtcag gacattgttg gagccgaaat     8640

ccgcgtgcac gaggtgccgg acttcggggc agtcctcggc ccaaagcatc agctcatcga     8700

gagcctgcgc gacggacgca ctgacggtgt cgtccatcac agtttgccag tgatacacat     8760

ggggatcagc aatcgcgcat atgaaatcac gccatgtagt gtattgaccg attccttgcg     8820

gtccgaatgg gccgaacccg ctcgtctggc taagatcggc cgcagcgatc gcatccatgg     8880

cctccgcgac cggctgcaga acagcgggca gttcggtttc aggcaggtct tgcaacgtga     8940

caccctgtgc acggcgggag atgcaatagg tcaggctctc gctgaattcc ccaatgtcaa     9000

gcacttccgg aatcgggagc gcggccgatg caaagtgccg ataaacataa cgatctttgt     9060

agaaaccatc ggcgcagcta tttacccgca ggacatatcc acgccctcct acatcgaagc     9120

tgaaagcacg agattcttcg ccctccgaga gctgcatcag gtcggagacg ctgtcgaact     9180

tttcgatcag aaacttctcg acagacgtcg cggtgagttc aggctttttc atatctcatt     9240

gccccccggg atctgcggca cgctgttgac gctgttaagc gggtcgctgc agggtcgctc     9300

ggtgttcgag gccacacgcg tcaccttaat atgcgaagtg gacctcggac cgcgccgccc     9360

cgactgcatc tgcgtgttcg aattcgccaa tgacaagacg ctgggcgggg tttgtgtcat     9420

catagaacta aagacatgca aatatatttc ttccggggac accgccagca aacgcgagca     9480

acgggccacg gggatgaagc agggcggcac ctcgctaacg gattcaccac tccaagaatt     9540

ggagccaatc aattcttgcg gagaactgtg aatgcgcaaa ccaacccttg gcagaacata     9600

tccatcgcgt ccgccatctc cagcagccgc acgcggcgca tctcggggcc gacgcgctgg     9660

gctacgtctt gctggcgttc gcacaggccg gccagcgcgc ggccggccgg taccacgcgt     9720

tggccacata tggcggccgc tcgcgattaa ttaatcgcga tggccacata tggagctctc     9780

tagagcttgt cgacagatcc ccctcttcat ttctttatgt tttaaatgca ctgacctccc     9840

acattccctt tttagtaaaa tattcagaaa taatttaaat acatcattgc aatgaaaata     9900

aatgtttttt attaggcaga atccagatgc tcaaggccct tcataatatc ccccagttta     9960

gtagttggac ttagggaaca aaggaacctt taatagaaat tggacagcaa gaaagcgagg    10020

gggatctgga tcctccggag ggccccttct ccctctaaca ctctcccctg ttgaagctct    10080

ttgtgacggg cgagctcagg ccctgatggg tgacttcgca ggcgtagact ttgtgtttct    10140

cgtagtctgc tttgctcagc gtcagggtgc tgctgaggct gtaggtgctg tccttgctgt    10200

cctgctctgt gacactctcc tgggagttac ccgattggag ggcgttatcc accttccact    10260

gtactttggc ctctctggga tagaagttat tcagcaggca cacaacagag gcagttccag    10320

atttcaactg ctcatcagat ggcgggaaga tgaagacaga tggtgcagcc actgtacgtt    10380

tgatctccac cttggtccct tggccgaaag tgtgaggtaa acgactactc tgatgacagt    10440

aatacactgc gaaatcttca ggctccagtc tactgatggt gagggtgaaa tctgtcccag    10500

atccactgcc actgaaccta tcggggatcc ctgagaggga ctgggatgca tacttgatga    10560

gaagccttgg agcctgacct ggtttctgct ggtaccagtg taagctacta ccaatgctct    10620

gactggcccg gcaggagagg gtggctctct cgcctggaga cacagacagg gtacctgggc    10680

tctgagtcag cacaatttca cccctggagg ctggaaccca gagcagcaga aacccaatga    10740

gttgtgatgg cgacatgtta aacgctagaa ttcttaagcc tgtggagaga aaggaacaga    10800

aaacgaaaca aagacgtaga gttgagcaag cagggtcagg caaagcgtgg agagccggct    10860

gagtctaggt aggctccaag ggagcgccgg acaaaggccc ggtctcgacc tgagctttaa    10920

acttacctgt ggccacacgt gcaattgcta tagtgagtcg tattaatttc gataagccag    10980

taagcagtgg gttctctagt tagccagaga gctctgctta tatagacctc ccaccgtaca    11040

cgcctaccgc ccatttgcgt caatggggcg gagttgttac gacattttgg aaagtcccgt    11100

tgattttggt gccaaaacaa actcccattg acgtcaatgg ggtggagact tggaaatccc    11160

cgtgagtcaa accgctatcc acgcccattg atgtactgcc aaaaccgcat caccatggta    11220

atagcgatga ctaatacgta gatgtactgc caagtaggaa agtcccataa ggtcatgtac    11280

tgggcataat gccaggcggg ccatttaccg tcattgacgt caataggggg cgtacttggc    11340

atatgataca cttgatgtac tgccaagtgg gcagtttacc gtaaatactc cacccattga    11400

cgtcaatgga aagtccctat tggcgttact atgggaacat acgtcattat tgacgtcaat    11460

gggcgggggt cgttgggcgg tcagccaggc gggccattta ccgtaagtta tgtaacgcgg    11520

aactccatat atgggctatg aactaatgac cccgtaattg attactatta ataactagtc    11580

aataatcaat gtcaacgcgt atatctggcc cgtacatcgt aactagtcgg accgccgcgg    11640

actagtgccc gggccaccgg tgctcgaagc ttggatcgat ccagacatga taagatacat    11700

tgatgagttt ggacaaacca caactagaat gcagtgaaaa aaatgcttta tttgtgaaat    11760

ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag ttaacaacaa    11820

caattgcatt cattttatgt ttcaggttca gggggaggtg tgggaggttt tttaaagcaa    11880

gtaaaacctc tacaaatgtg gtatggctga ttatgatctc tagtcaag                 11928


<210>  36
<211>  11928
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAIG1FRLCb2V3 plasmid sequence

<400>  36
gcactataca tcaaatattc cttattaacc cctttacaaa ttaaaaagct aaaggtacac       60

aatttttgag catagttatt aatagcagac actctatgcc tgtgtggagt aagaaaaaac      120

agtatgttat gattataact gttatgccta cttataaagg ttacagaata tttttccata      180

attttcttgt atagcagtgc agctttttcc tttgtggtgt aaatagcaaa gcaagcaaga      240

gttctattac taaacacagc atgactcaaa aaacttagca attctgaagg aaagtccttg      300

gggtcttcta cctttctctt cttttttgga ggagtagaat gttgagagtc agcagtagcc      360

tcatcatcac tagatggcat ttcttctgag caaaacaggt tttcctcatt aaaggcattc      420

caccactgct cccattcatc agttccatag gttggaatct aaaatacaca aacaattaga      480

atcagtagtt taacacatta tacacttaaa aattttatat ttaccttaga gctttaaatc      540

tctgtaggta gtttgtccaa ttatgtcaca ccacagaagt aaggttcctt cacaaagatc      600

gatctaaagc cagcaaaagt cccatggtct tataaaaatg catagcttta ggaggggagc      660

agagaacttg aaagcatctt cctgttagtc tttcttctcg tagacttcaa acttatactt      720

gatgcctttt tcctcctgga cctcagagag gacgcctggg tattctggga gaagtttata      780

tttccccaaa tcaatttctg ggaaaaacgt gtcactttca aattcctgca tgatccttgt      840

cacaaagagt ctgaggtggc ctggttgatt catggcttcc tggtaaacag aactgcctcc      900

gactatccaa accatgtcta ctttacttgc caattccggt tgttcaataa gtcttaaggc      960

atcatccaaa cttttggcaa gaaaatgagc tcctcgtggt ggttctttga gttctctact     1020

gagaactata ttaattctgt cctttaaagg tcgattcttc tcaggaatgg agaaccaggt     1080

tttcctaccc ataatcacca gattctgttt accttccact gaagaggttg tggtcattct     1140

ttggaagtac ttgaactcgt tcctgagcgg aggccagggt aggtctccgt tcttgccaat     1200

ccccatattt tgggacacgg cgacgatgca gttcaatggt cgaaccatga tggcagcggg     1260

gataaaatcc taccagcctt cacgctagga ttgccgtcaa gtttggcgcg aaatcgcagc     1320

cctgagctgt cccccccccc aagctcagat ctgagcttgg tccctatggt gagtccgttc     1380

cgctcttgtg atgatagcca gacaagaaag agacaataca agacaaacac caaatagtag     1440

aaatagagac aagggtcact tatccgaggg tccctgttcg ggcgccagct gccgcagtcg     1500

gccgacctga gggtcgccgg ggtctgcggg gggaccctct ggaaagtgaa ggataagtga     1560

cgagcggaga cgggatggcg aacagacaca aacacacaag aggtgaatgt taggactgtt     1620

gcaagtttac tcaaaaaatc agcactcttt tatatcttgg tttacataag catttacata     1680

agatttggat aaattccaaa agaacatagg aaaatagaac actcagagct cagatcagaa     1740

cctttgatac caaaccaagt caggaaacca cttgtctcac atcctcgttt taagaacagt     1800

ttgtaaccaa aaacttactt aagccctggg aaccgcaagg ttgggccaat aaaggctatt     1860

cataataact catgccatga gtttttgcag aataatgttc tattagtcca gccactgtcc     1920

cctccttggt atggaaaatc tttccccaaa agtgcattcc tgttcctaga taaatataat     1980

catgtacctg ttgtttcatg tcgtcttttt cttcttgaga caacatacac caaggaggtc     2040

tagctctggc gagtctttca cgaaaaggga gggatctata taacacttta tagccattga     2100

ctgtaaccca cctatcccaa tttaagtcat atcttcctgt atatggtaag ggggcatctg     2160

ttggtctgta gatgtaaggt cccctataag tccctggttg ccaccacctg tctcctattt     2220

tgacaaaaac actctttttt ccctttttta cttctaggcc tgtggtcaat agtccttgca     2280

cctgttcttc aattgaggtt gagcgtctct ttctattttc tattcccatt tctaacttct     2340

gaatttgagt aaaaatagta ctaaaagata atgattcatt tcttaacata gtaactaata     2400

atctacctat tggattggtc ttattggtaa aaatataatt tttagcaagc attcttattt     2460

ctatttctga aggacaaaat cgatgcggct tgtaagagga agttggctgt ggtccttgcc     2520

tcaggaggaa ggtcgagttc tccgaattgt ttagattgta atcttgcaca gaagagctat     2580

taaaagagtc aagggtgaga gccctgcgag cacgaaccgc aacttccccc aatagcccca     2640

ggcaaagcag agctatgcca agtttgcagc agagaatgaa tatgtctttg tctgatgggc     2700

tcatccgttt gtgcgcagac gggtcgtcct tggtgggaaa caaccccttg gctgcttctc     2760

ccctaggtgt aggacactct cgggagttca accatttctg cccaagctca gatctgagct     2820

ttaatgcggt agtttatcac agttaaattg ctaacgcagt caggcaccgt gtatgaaatc     2880

taacaatgcg ctcatcgtca tcctcggcac cgtcaccctg gatgctgtag gcataggctt     2940

ggttatgccg gtactgccgg gcctcttgcg ggatatcgtc cattccgaca gcatcgccag     3000

tcactatggc gtgctgctag cgctcttccg cttcctcgct cactgactcg ctgcgctcgg     3060

tcgttcggct gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag     3120

aatcagggga taacgcagga aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc     3180

gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca     3240

aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt     3300

ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc     3360

tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc     3420

tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc     3480

ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact     3540

tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg     3600

ctacagagtt cttgaagtgg tggcctaact acggctacac tagaaggaca gtatttggta     3660

tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca     3720

aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa     3780

aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct cagtggaacg     3840

aaaactcacg ttaagggatt ttggtcatga gattatcaaa aaggatcttc acctagatcc     3900

ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa acttggtctg     3960

acagttacca atgcttaatc agtgaggcac ctatctcagc gatctgtcta tttcgttcat     4020

ccatagttgc ctgactcccc gtcgtgtaga taactacgat acgggagggc ttaccatctg     4080

gccccagtgc tgcaatgata ccgcgagacc cacgctcacc ggctccagat ttatcagcaa     4140

taaaccagcc agccggaagg gccgagcgca gaagtggtcc tgcaacttta tccgcctcca     4200

tccagtctat taattgttgc cgggaagcta gagtaagtag ttcgccagtt aatagtttgc     4260

gcaacgttgt tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt     4320

cattcagctc cggttcccaa cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa     4380

aagcggttag ctccttcggt cctccgatcg ttgtcagaag taagttggcc gcagtgttat     4440

cactcatggt tatggcagca ctgcataatt ctcttactgt catgccatcc gtaagatgct     4500

tttctgtgac tggtgagtac tcaaccaagt cattctgaga atagtgtatg cggcgaccga     4560

gttgctcttg cccggcgtca acacgggata ataccgcgcc acatagcaga actttaaaag     4620

tgctcatcat tggaaaacgt tcttcggggc gaaaactctc aaggatctta ccgctgttga     4680

gatccagttc gatgtaaccc actcgtgcac ccaactgatc ttcagcatct tttactttca     4740

ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg     4800

cgacacggaa atgttgaata ctcatactct tcctttttca atattattga agcatttatc     4860

agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat aaacaaatag     4920

gggttccgcg cacatttccc cgaaaagtgc cacctgacgt ctaagaaacc attattatca     4980

tgacattaac ctataaaaat aggcgtatca cgaggccctt tcgtcttcaa gaattgtcta     5040

gaggcgcgct ggccggcctg tgcgaacgcc agcaagacgt agcccagcgc gtcggccccg     5100

agatgcgccg cgtgcggctg ctggagatgg cggacgcgat ggatatgttc tgccaagggt     5160

tggtttgcgc attcacagtt ctccgcaaga attgattggc tccaattctt ggagtggtga     5220

atccgttagc gaggtgccgc cctgcttcat ccccgtggcc cgttgctcgc gtttgctggc     5280

ggtgtccccg gaagaaatat atttgcatgt ctttagttct atgatgacac aaaccccgcc     5340

cagcgtcttg tcattggcga attcgaacac gcagatgcag tcggggcggc gcggtccgag     5400

gtccacttcg catattaagg tgacgcgtgt ggcctcgaac accgagcgac cctgcagcga     5460

cccgcttaac agcgtcaaca gcgtgccgca gatcccgggg ggcaatgaga tatgaaaaag     5520

cctgaactca ccgcgacgtc tgtcgagaag tttctgatcg aaaagttcga cagcgtctcc     5580

gacctgatgc agctctcgga gggcgaagaa tctcgtgctt tcagcttcga tgtaggaggg     5640

cgtggatatg tcctgcgggt aaatagctgc gccgatggtt tctacaaaga tcgttatgtt     5700

tatcggcact ttgcatcggc cgcgctcccg attccggaag tgcttgacat tggggaattc     5760

agcgagagcc tgacctattg catctcccgc cgtgcacagg gtgtcacgtt gcaagacctg     5820

cctgaaaccg aactgcccgc tgttctgcag ccggtcgcgg aggccatgga tgcgatcgct     5880

gcggccgatc ttagccagac gagcgggttc ggcccattcg gaccgcaagg aatcggtcaa     5940

tacactacat ggcgtgattt catatgcgcg attgctgatc cccatgtgta tcactggcaa     6000

actgtgatgg acgacaccgt cagtgcgtcc gtcgcgcagg ctctcgatga gctgatgctt     6060

tgggccgagg actgccccga agtccggcac ctcgtgcacg cggatttcgg ctccaacaat     6120

gtcctgacgg acaatggccg cataacagcg gtcattgact ggagcgaggc gatgttcggg     6180

gattcccaat acgaggtcgc caacatcttc ttctggaggc cgtggttggc ttgtatggag     6240

cagcagacgc gctacttcga gcggaggcat ccggagcttg caggatcgcc gcggctccgg     6300

gcgtatatgc tccgcattgg tcttgaccaa ctctatcaga gcttggttga cggcaatttc     6360

gatgatgcag cttgggcgca gggtcgatgc gacgcaatcg tccgatccgg agccgggact     6420

gtcgggcgta cacaaatcgc ccgcagaagc gcggccgtct ggaccgatgg ctgtgtagaa     6480

gtactcgccg atagtggaaa ccgacgcccc agcactcgtc cggatcggga gatgggggag     6540

gctaactgaa acacggaagg agacaatacc ggaaggaacc cgcgctatga cggcaataaa     6600

aagacagaat aaaacgcacg ggtgttgggt cgtttgttca taaacgcggg gttcggtccc     6660

agggctggca ctctgtcgat accccaccga gaccccattg gggccaatac gcccgcgttt     6720

cttccttttc cccaccccac cccccaagtt cgggtgaagg cccagggctc gcagccaacg     6780

tcggggcggc aggccctgcc atagccactg gccccgtggg ttagggacgg ggtcccccat     6840

ggggaatggt ttatggttcg tgggggttat tattttgggc gttgcgtggg gtcaggtcca     6900

cgactggact gagcagacag acccatggtt tttggatggc ctgggcatgg accgcatgta     6960

ctggcgcgac acgaacaccg ggcgtctgtg gctgccaaac acccccgacc cccaaaaacc     7020

accgcgcgga tttctggcgt gccaagctag tcgaaagctt ggccggcctg tacatgatca     7080

acgcgtgagc tctctagagc ttgtcgacag atccccctct tcatttcttt atgttttaaa     7140

tgcactgacc tcccacattc cctttttagt aaaatattca gaaataattt aaatacatca     7200

ttgcaatgaa aataaatgtt ttttattagg cagaatccag atgctcaagg cccttcataa     7260

tatcccccag tttagtagtt ggacttaggg aacaaaggaa cctttaatag aaattggaca     7320

gcaagaaagc gagggggatc tggatcctcc ggacccgtat ctagaatcat cgattcattt     7380

acccggagac agggagaggc tcttctgcgt gtagtggttg tgcagagcct catgcatcac     7440

ggagcatgag aagacgttcc cctgctgcca cctgctcttg tccacggtga gcttgctgta     7500

gaggaagaag gagccgtcgg agtccagcac gggaggcgtg gtcttgtagt tgttctccgg     7560

ctgcccattg ctctcccact ccacggcgat gtcgctggga tagaagcctt tgaccaggca     7620

ggtcaggctg acctggttct tggtcagctc atcccgggat gggggcaggg tgtacacctg     7680

tggttctcgg ggctgccctt tggctttgga gatggttttc tcgatggggg ctgggagggc     7740

tttgttggag accttgcact tgtactcctt gccattcagc cagtcctggt gcaggacggt     7800

gaggacgctg accacacggt acgtgctgtt gtactgctcc tcccgcggct ttgtcttggc     7860

attatgcacc tccacgccgt ccacgtacca gttgaacttg acctcagggt cttcgtggct     7920

cacgtccacc accacgcatg tgacctcagg ggtccgggag atcatgaggg tgtccttggg     7980

ttttgggggg aagaggaaga ctgacggtcc ccccaggagt tcaggtgctg ggcacggtgg     8040

gcatgtgtga gttttgtcac aagatttggg ctcaactttc ttgtccacct tggtgttgct     8100

gggcttgtga ttcacgttgc agatgtaggt ctgggtgccc aagctgctgg agggcacggt     8160

caccacgctg ctgagggagt agagtcctga ggactgtagg acagccggga aggtgtgcac     8220

gccgctggtc agggcgcctg agttccacga caccgtcacc ggttcgggga agtagtcctt     8280

gaccaggcag cccagggccg ctgtgccccc agaggtgctc ttggaggagg gtgccagggg     8340

gaagaccgat gggcccttgg tggaagctga ggagacggtg accgtggtcc cttggcccca     8400

gacgtccata ccgtagtaga agttccccag tcttgcacag taatacacag cagtgtcctc     8460

ggctctcagg ctgttcattt gaagatacaa ggagttcttg gcattgtctc tggagatggt     8520

gaatcggccc ttcacggagt ctgcatagta tgtggcacca cgagtatcaa taactgatat     8580

ccactccaga ccttttcctg gagcctggcg aacccagtgc atagcaaagc tactgaaggt     8640

gaatccagag gctgcacagg agagtctcag ggacccccca ggctttacca agcctccccc     8700

agactgcacc agctgaacct cacactggac accttttaat atagcaacaa ggaaaaccca     8760

gctcagccca aactccataa gggcgaattc caccacactg gactagtgga tccgagctcg     8820

gtaccaagct taagcctgtg gagagaaagg aacagaaaac gaaacaaaga cgtagagttg     8880

agcaagcagg gtcaggcaaa gcgtggagag ccggctgagt ctaggtaggc tccaagggag     8940

cgccggacaa aggcccggtc tcgacctgag ctttaaactt acctgtggcc acacgtgcaa     9000

ttgctatagt gagtcgtatt aatttcgata agccagtaag cagtgggttc tctagttagc     9060

cagagagctc tgcttatata gacctcccac cgtacacgcc taccgcccat ttgcgtcaat     9120

ggggcggagt tgttacgaca ttttggaaag tcccgttgat tttggtgcca aaacaaactc     9180

ccattgacgt caatggggtg gagacttgga aatccccgtg agtcaaaccg ctatccacgc     9240

ccattgatgt actgccaaaa ccgcatcacc atggtaatag cgatgactaa tacgtagatg     9300

tactgccaag taggaaagtc ccataaggtc atgtactggg cataatgcca ggcgggccat     9360

ttaccgtcat tgacgtcaat agggggcgta cttggcatat gatacacttg atgtactgcc     9420

aagtgggcag tttaccgtaa atactccacc cattgacgtc aatggaaagt ccctattggc     9480

gttactatgg gaacatacgt cattattgac gtcaatgggc gggggtcgtt gggcggtcag     9540

ccaggcgggc catttaccgt aagttatgta acgcggaact ccatatatgg gctatgaact     9600

aatgaccccg taattgatta ctattaataa ctagtcaata atcaatgtca acgcgtatat     9660

ctggcccgta catcggtagc tgagggttta aacggcgcgc ggccggccgg taccacgcgt     9720

tggccacata tggcggccgc tcgcgattaa ttaatcgcga tggccacata tggagctctc     9780

tagagcttgt cgacagatcc ccctcttcat ttctttatgt tttaaatgca ctgacctccc     9840

acattccctt tttagtaaaa tattcagaaa taatttaaat acatcattgc aatgaaaata     9900

aatgtttttt attaggcaga atccagatgc tcaaggccct tcataatatc ccccagttta     9960

gtagttggac ttagggaaca aaggaacctt taatagaaat tggacagcaa gaaagcgagg    10020

gggatctgga tcctccggag ggccccttct ccctctaaca ctctcccctg ttgaagctct    10080

ttgtgacggg cgagctcagg ccctgatggg tgacttcgca ggcgtagact ttgtgtttct    10140

cgtagtctgc tttgctcagc gtcagggtgc tgctgaggct gtaggtgctg tccttgctgt    10200

cctgctctgt gacactctcc tgggagttac ccgattggag ggcgttatcc accttccact    10260

gtactttggc ctctctggga tagaagttat tcagcaggca cacaacagag gcagttccag    10320

atttcaactg ctcatcagat ggcgggaaga tgaagacaga tggtgcagcc actgtacgtt    10380

tgatctccac cttggtccct tggccgaaag tgtgaggtaa acgactactc tgatgacagt    10440

aatacactgc gaaatcttca ggctccagtc tactgatggt gagggtgaaa tctgtcccag    10500

atccactgcc actgaaccta tcggggatcc ctgagaggga ctgggatgca tacttgatga    10560

gaagccttgg agcctgacct ggtttctgct ggtaccagtg taagctacta ccaatgctct    10620

gactggcccg gcaggagagg gtggctctct cgcctggaga cacagacagg gtacctgggc    10680

tctgagtcag cacaatttca cccctggagg ctggaaccca gagcagcaga aacccaatga    10740

gttgtgatgg cgacatgtta aacgctagaa ttcttaagcc tgtggagaga aaggaacaga    10800

aaacgaaaca aagacgtaga gttgagcaag cagggtcagg caaagcgtgg agagccggct    10860

gagtctaggt aggctccaag ggagcgccgg acaaaggccc ggtctcgacc tgagctttaa    10920

acttacctgt ggccacacgt gcaattgcta tagtgagtcg tattaatttc gataagccag    10980

taagcagtgg gttctctagt tagccagaga gctctgctta tatagacctc ccaccgtaca    11040

cgcctaccgc ccatttgcgt caatggggcg gagttgttac gacattttgg aaagtcccgt    11100

tgattttggt gccaaaacaa actcccattg acgtcaatgg ggtggagact tggaaatccc    11160

cgtgagtcaa accgctatcc acgcccattg atgtactgcc aaaaccgcat caccatggta    11220

atagcgatga ctaatacgta gatgtactgc caagtaggaa agtcccataa ggtcatgtac    11280

tgggcataat gccaggcggg ccatttaccg tcattgacgt caataggggg cgtacttggc    11340

atatgataca cttgatgtac tgccaagtgg gcagtttacc gtaaatactc cacccattga    11400

cgtcaatgga aagtccctat tggcgttact atgggaacat acgtcattat tgacgtcaat    11460

gggcgggggt cgttgggcgg tcagccaggc gggccattta ccgtaagtta tgtaacgcgg    11520

aactccatat atgggctatg aactaatgac cccgtaattg attactatta ataactagtc    11580

aataatcaat gtcaacgcgt atatctggcc cgtacatcgt aactagtcgg accgccgcgg    11640

actagtgccc gggccaccgg tgctcgaagc ttggatcgat ccagacatga taagatacat    11700

tgatgagttt ggacaaacca caactagaat gcagtgaaaa aaatgcttta tttgtgaaat    11760

ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag ttaacaacaa    11820

caattgcatt cattttatgt ttcaggttca gggggaggtg tgggaggttt tttaaagcaa    11880

gtaaaacctc tacaaatgtg gtatggctga ttatgatctc tagtcaag                 11928


<210>  37
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' primer

<400>  37
gcttggtacc gccgccacca tggagtttgg gctgagctgg gtttt                       45


<210>  38
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' primer

<400>  38
agaccgatgg gcccttggtg gaagctgagg                                        30


<210>  39
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' primer

<400>  39
gaattcgttt aaacgccgcc accatgtcgc catcacaact cattgggt                    48


<210>  40
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' primer

<400>  40
ccaccgtacg tttgatctcc accttggtcc ctt                                    33


<210>  41
<211>  8376
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAIG1FRH-K plasmid sequence

<400>  41
tataaatcaa aagaatagac cgagataggg ttgagtgttg ttccagtttg gaacaagagt       60

ccactattaa agaacgtgga ctccaacgtc aaagggcgaa aaaccgtcta tcagggcgat      120

ggcccactac gtgaaccatc accctaatca agttttttgg ggtcgaggtg ccgtaaagca      180

ctaaatcgga accctaaagg gagcccccga tttagagctt gacggggaaa gccggcgaac      240

gtggcgagaa aggaagggaa gaaagcgaaa ggagcgggcg ctagggcgct ggcaagtgta      300

gcggtcacgc tgcgcgtaac caccacaccc gccgcgctta atgcgccgct acagggcgcg      360

tcccattcgc cattcaggct gcgcaactgt tgggaagggc gatcggtgcg ggcctcttcg      420

ctattacgcc agctggcgaa agggggatgt gctgcaaggc gattaagttg ggtaacgcca      480

gggttttccc agtcacgacg ttgtaaaacg acggccagtg agcgcgctgg ccggcctgtg      540

cgaacgccag caagacgtag cccagcgcgt cggccccgag atgcgccgcg tgcggctgct      600

ggagatggcg gacgcgatgg atatgttctg ccaagggttg gtttgcgcat tcacagttct      660

ccgcaagaat tgattggctc caattcttgg agtggtgaat ccgttagcga ggtgccgccc      720

tgcttcatcc ccgtggcccg ttgctcgcgt ttgctggcgg tgtccccgga agaaatatat      780

ttgcatgtct ttagttctat gatgacacaa accccgccca gcgtcttgtc attggcgaat      840

tcgaacacgc agatgcagtc ggggcggcgc ggtccgaggt ccacttcgca tattaaggtg      900

acgcgtgtgg cctcgaacac cgagcgaccc tgcagcgacc cgcttaacag cgtcaacagc      960

gtgccgcaga tcccgggggg caatgagata tgaaaaagcc tgaactcacc gcgacgtctg     1020

tcgagaagtt tctgatcgaa aagttcgaca gcgtctccga cctgatgcag ctctcggagg     1080

gcgaagaatc tcgtgctttc agcttcgatg taggagggcg tggatatgtc ctgcgggtaa     1140

atagctgcgc cgatggtttc tacaaagatc gttatgttta tcggcacttt gcatcggccg     1200

cgctcccgat tccggaagtg cttgacattg gggaattcag cgagagcctg acctattgca     1260

tctcccgccg tgcacagggt gtcacgttgc aagacctgcc tgaaaccgaa ctgcccgctg     1320

ttctgcagcc ggtcgcggag gccatggatg cgatcgctgc ggccgatctt agccagacga     1380

gcgggttcgg cccattcgga ccgcaaggaa tcggtcaata cactacatgg cgtgatttca     1440

tatgcgcgat tgctgatccc catgtgtatc actggcaaac tgtgatggac gacaccgtca     1500

gtgcgtccgt cgcgcaggct ctcgatgagc tgatgctttg ggccgaggac tgccccgaag     1560

tccggcacct cgtgcacgcg gatttcggct ccaacaatgt cctgacggac aatggccgca     1620

taacagcggt cattgactgg agcgaggcga tgttcgggga ttcccaatac gaggtcgcca     1680

acatcttctt ctggaggccg tggttggctt gtatggagca gcagacgcgc tacttcgagc     1740

ggaggcatcc ggagcttgca ggatcgccgc ggctccgggc gtatatgctc cgcattggtc     1800

ttgaccaact ctatcagagc ttggttgacg gcaatttcga tgatgcagct tgggcgcagg     1860

gtcgatgcga cgcaatcgtc cgatccggag ccgggactgt cgggcgtaca caaatcgccc     1920

gcagaagcgc ggccgtctgg accgatggct gtgtagaagt actcgccgat agtggaaacc     1980

gacgccccag cactcgtccg gatcgggaga tgggggaggc taactgaaac acggaaggag     2040

acaataccgg aaggaacccg cgctatgacg gcaataaaaa gacagaataa aacgcacggg     2100

tgttgggtcg tttgttcata aacgcggggt tcggtcccag ggctggcact ctgtcgatac     2160

cccaccgaga ccccattggg gccaatacgc ccgcgtttct tccttttccc caccccaccc     2220

cccaagttcg ggtgaaggcc cagggctcgc agccaacgtc ggggcggcag gccctgccat     2280

agccactggc cccgtgggtt agggacgggg tcccccatgg ggaatggttt atggttcgtg     2340

ggggttatta ttttgggcgt tgcgtggggt caggtccacg actggactga gcagacagac     2400

ccatggtttt tggatggcct gggcatggac cgcatgtact ggcgcgacac gaacaccggg     2460

cgtctgtggc tgccaaacac ccccgacccc caaaaaccac cgcgcggatt tctggcgtgc     2520

caagctagtc gaaagcttgg ccggcctgta catgatcaac gcgtgagctc tctagagctt     2580

gtcgacagat ccccctcttc atttctttat gttttaaatg cactgacctc ccacattccc     2640

tttttagtaa aatattcaga aataatttaa atacatcatt gcaatgaaaa taaatgtttt     2700

ttattaggca gaatccagat gctcaaggcc cttcataata tcccccagtt tagtagttgg     2760

acttagggaa caaaggaacc tttaatagaa attggacagc aagaaagcga gggggatctg     2820

gatcctccgg acccgtatct agaatcatcg attcatttac ccggagacag ggagaggctc     2880

ttctgcgtgt agtggttgtg cagagcctca tgcatcacgg agcatgagaa gacgttcccc     2940

tgctgccacc tgctcttgtc cacggtgagc ttgctgtaga ggaagaagga gccgtcggag     3000

tccagcacgg gaggcgtggt cttgtagttg ttctccggct gcccattgct ctcccactcc     3060

acggcgatgt cgctgggata gaagcctttg accaggcagg tcaggctgac ctggttcttg     3120

gtcagctcat cccgggatgg gggcagggtg tacacctgtg gttctcgggg ctgccctttg     3180

gctttggaga tggttttctc gatgggggct gggagggctt tgttggagac cttgcacttg     3240

tactccttgc cattcagcca gtcctggtgc aggacggtga ggacgctgac cacacggtac     3300

gtgctgttgt actgctcctc ccgcggcttt gtcttggcat tatgcacctc cacgccgtcc     3360

acgtaccagt tgaacttgac ctcagggtct tcgtggctca cgtccaccac cacgcatgtg     3420

acctcagggg tccgggagat catgagggtg tccttgggtt ttggggggaa gaggaagact     3480

gacggtcccc ccaggagttc aggtgctggg cacggtgggc atgtgtgagt tttgtcacaa     3540

gatttgggct caactttctt gtccaccttg gtgttgctgg gcttgtgatt cacgttgcag     3600

atgtaggtct gggtgcccaa gctgctggag ggcacggtca ccacgctgct gagggagtag     3660

agtcctgagg actgtaggac agccgggaag gtgtgcacgc cgctggtcag ggcgcctgag     3720

ttccacgaca ccgtcaccgg ttcggggaag tagtccttga ccaggcagcc cagggccgct     3780

gtgcccccag aggtgctctt ggaggagggt gccaggggga agaccgatgg gcccttggtg     3840

gaagctgagg agacggtgac cgtggtccct tggccccaga cgtccatacc gtagtagaag     3900

ttccccagtc ttgcacagta atacacagca gtgtcctcgg ctctcaggct gttcatttga     3960

agatacaagg agttcttggc attgtctctg gagatggtga atcggccctt cacggagtct     4020

gcatagtatg tggcaccacg agtatcaata actgatatcc actccagacc ttttcctgga     4080

gcctggcgaa cccagtgcat agcaaagcta ctgaaggtga atccagaggc tgcacaggag     4140

agtctcaggg accccccagg ctttaccaag cctcccccag actgcaccag ctgaacctca     4200

cactggacac cttttaatat agcaacaagg aaaacccagc tcagcccaaa ctccatggtg     4260

gcggcggtac caagcttaag cctgtggaga gaaaggaaca gaaaacgaaa caaagacgta     4320

gagttgagca agcagggtca ggcaaagcgt ggagagccgg ctgagtctag gtaggctcca     4380

agggagcgcc ggacaaaggc ccggtctcga cctgagcttt aaacttacct gtggccacac     4440

gtgcaattgc tatagtgagt cgtattaatt tcgataagcc agtaagcagt gggttctcta     4500

gttagccaga gagctctgct tatatagacc tcccaccgta cacgcctacc gcccatttgc     4560

gtcaatgggg cggagttgtt acgacatttt ggaaagtccc gttgattttg gtgccaaaac     4620

aaactcccat tgacgtcaat ggggtggaga cttggaaatc cccgtgagtc aaaccgctat     4680

ccacgcccat tgatgtactg ccaaaaccgc atcaccatgg taatagcgat gactaatacg     4740

tagatgtact gccaagtagg aaagtcccat aaggtcatgt actgggcata atgccaggcg     4800

ggccatttac cgtcattgac gtcaataggg ggcgtacttg gcatatgata cacttgatgt     4860

actgccaagt gggcagttta ccgtaaatag tccacccatt gacgtcaatg gaaagtccct     4920

attggcgtta ctatgggaac atacgtcatt attgacgtca atgggcgggg gtcgttgggc     4980

ggtcagccag gcgggccatt taccgtaagt tatgtaacgc ggaactccat atatgggcta     5040

tgaactaatg accccgtaat tgattactat taataactag tcaataatca atgtcaacgc     5100

gtatatctgg cccgtacatc ggtagctgag ggtttaaacg gcgcgcttgg cgtaatcatg     5160

gtcatagctg tttcctgtgt gaaattgtta tccgctcaca attccacaca acatacgagc     5220

cggaagcata aagtgtaaag cctggggtgc ctaatgagtg agctaactca cattaattgc     5280

gttgcgctca ctgcccgctt tccagtcggg aaacctgtcg tgccagctgc attaatgaat     5340

cggccaacgc gcggggagag gcggtttgcg tattgggcgc tcttccgctt cctcgctcac     5400

tgactcgctg cgctcggtcg ttcggctgcg gcgagcggta tcagctcact caaaggcggt     5460

aatacggtta tccacagaat caggggataa cgcaggaaag aacatgtgag caaaaggcca     5520

gcaaaaggcc aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc     5580

ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc cgacaggact     5640

ataaagatac caggcgtttc cccctggaag ctccctcgtg cgctctcctg ttccgaccct     5700

gccgcttacc ggatacctgt ccgcctttct cccttcggga agcgtggcgc tttctcatag     5760

ctcacgctgt aggtatctca gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca     5820

cgaacccccc gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa     5880

cccggtaaga cacgacttat cgccactggc agcagccact ggtaacagga ttagcagagc     5940

gaggtatgta ggcggtgcta cagagttctt gaagtggtgg cctaactacg gctacactag     6000

aaggacagta tttggtatct gcgctctgct gaagccagtt accttcggaa aaagagttgg     6060

tagctcttga tccggcaaac aaaccaccgc tggtagcggt ggtttttttg tttgcaagca     6120

gcagattacg cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc     6180

tgacgctcag tggaacgaaa actcacgtta agggattttg gtcatgagat tatcaaaaag     6240

gatcttcacc tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata     6300

tgagtaaact tggtctgaca gttaccaatg cttaatcagt gaggcaccta tctcagcgat     6360

ctgtctattt cgttcatcca tagttgcctg actccccgtc gtgtagataa ctacgatacg     6420

ggagggctta ccatctggcc ccagtgctgc aatgataccg cgagacccac gctcaccggc     6480

tccagattta tcagcaataa accagccagc cggaagggcc gagcgcagaa gtggtcctgc     6540

aactttatcc gcctccatcc agtctattaa ttgttgccgg gaagctagag taagtagttc     6600

gccagttaat agtttgcgca acgcctgaat cgccccatca tccagccaga aagtgaggga     6660

gccacggttg atgagagctt tgttgtaggt ggaccagttg gtgattttga acttttgctt     6720

tgccacggaa cggtctgcgt tgtcgggaag atgcgtgatc tgatccttca actcagcaaa     6780

agttcgattt attcaacaaa gccgccgtcc cgtcaagtca gcgtaatgct ctgccagtgt     6840

tacaaccaat taaccaattc tgattagaaa aactcatcga gcatcaaatg aaactgcaat     6900

ttattcatat caggattatc aataccatat ttttgaaaaa gccgtttctg taatgaagga     6960

gaaaactcac cgaggcagtt ccataggatg gcaagatcct ggtatcggtc tgcgattccg     7020

actcgtccaa catcaataca acctattaat ttcccctcgt caaaaataag gttatcaagt     7080

gagaaatcac catgagtgac gactgaatcc ggtgagaatg gcaaaagctt atgcatttct     7140

ttccagactt gttcaacagg ccagccatta cgctcgtcat caaaatcact cgcatcaacc     7200

aaaccgttat tcattcgtga ttgcgcctga gcgagacgaa atacgcgatc gctgttaaaa     7260

ggacaattac aaacaggaat cgaatgcaac cggcgcagga acactgccag cgcatcaaca     7320

atattttcac ctgaatcagg atattcttct aatacctgga atgctgtttt cccggggatc     7380

gcagtggtga gtaaccatgc atcatcagga gtacggataa aatgcttgat ggtcggaaga     7440

ggcataaatt ccgtcagcca gtttagtctg accatctcat ctgtaacatc attggcaacg     7500

ctacctttgc catgtttcag aaacaactct ggcgcatcgg gcttcccata caatcgatag     7560

attgtcgcac ctgattgccc gacattatcg cgagcccatt tatacccata taaatcagca     7620

tccatgttgg aatttaatcg cggcctcgag caagacgttt cccgttgaat atggctcata     7680

acaccccttg tattactgtt tatgtaagca gacagtttta ttgttcatga tgatatattt     7740

ttatcttgtg caatgtaaca tcagagattt tgagacacaa cgtggctttg ttgaataaat     7800

cgaacttttg ctgagttgaa ggatcagatc acgcatcttc ccgacaacgc agaccgttcc     7860

gtggcaaagc aaaagttcaa aatcaccaac tggtccacct acaacaaagc tctcatcaac     7920

cgtggctccc tcactttctg gctggatgat ggggcgattc aggcgttctt cggggcgaaa     7980

actctcaagg atcttaccgc tgttgagatc cagttcgatg taacccactc gtgcacccaa     8040

ctgatcttca gcatctttta ctttcaccag cgtttctggg tgagcaaaaa caggaaggca     8100

aaatgccgca aaaaagggaa taagggcgac acggaaatgt tgaatactca tactcttcct     8160

ttttcaatat tattgaagca tttatcaggg ttattgtctc atgagcggat acatatttga     8220

atgtatttag aaaaataaac aaataggggt tccgcgcaca tttccccgaa aagtgccacc     8280

taaattgtaa gcgttaatat tttgttaaaa ttcgcgttaa atttttgtta aatcagctca     8340

ttttttaacc aataggccga aatcggcaaa atccct                               8376


<210>  42
<211>  7333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAIGFRLCb2(-)L-K plasmid sequence

<400>  42
gcactataca tcaaatattc cttattaacc cctttacaaa ttaaaaagct aaaggtacac       60

aatttttgag catagttatt aatagcagac actctatgcc tgtgtggagt aagaaaaaac      120

agtatgttat gattataact gttatgccta cttataaagg ttacagaata tttttccata      180

attttcttgt atagcagtgc agctttttcc tttgtggtgt aaatagcaaa gcaagcaaga      240

gttctattac taaacacagc atgactcaaa aaacttagca attctgaagg aaagtccttg      300

gggtcttcta cctttctctt cttttttgga ggagtagaat gttgagagtc agcagtagcc      360

tcatcatcac tagatggcat ttcttctgag caaaacaggt tttcctcatt aaaggcattc      420

caccactgct cccattcatc agttccatag gttggaatct aaaatacaca aacaattaga      480

atcagtagtt taacacatta tacacttaaa aattttatat ttaccttaga gctttaaatc      540

tctgtaggta gtttgtccaa ttatgtcaca ccacagaagt aaggttcctt cacaaagatc      600

gatctaaagc cagcaaaagt cccatggtct tataaaaatg catagcttta ggaggggagc      660

agagaacttg aaagcatctt cctgttagtc tttcttctcg tagacttcaa acttatactt      720

gatgcctttt tcctcctgga cctcagagag gacgcctggg tattctggga gaagtttata      780

tttccccaaa tcaatttctg ggaaaaacgt gtcactttca aattcctgca tgatccttgt      840

cacaaagagt ctgaggtggc ctggttgatt catggcttcc tggtaaacag aactgcctcc      900

gactatccaa accatgtcta ctttacttgc caattccggt tgttcaataa gtcttaaggc      960

atcatccaaa cttttggcaa gaaaatgagc tcctcgtggt ggttctttga gttctctact     1020

gagaactata ttaattctgt cctttaaagg tcgattcttc tcaggaatgg agaaccaggt     1080

tttcctaccc ataatcacca gattctgttt accttccact gaagaggttg tggtcattct     1140

ttggaagtac ttgaactcgt tcctgagcgg aggccagggt aggtctccgt tcttgccaat     1200

ccccatattt tgggacacgg cgacgatgca gttcaatggt cgaaccatga tggcagcggg     1260

gataaaatcc taccagcctt cacgctagga ttgccgtcaa gtttggcgcg aaatcgcagc     1320

cctgagctgt cccccccccc aagctcagat ctgagcttgg tccctatggt gagtccgttc     1380

cgctcttgtg atgatagcca gacaagaaag agacaataca agacaaacac caaatagtag     1440

aaatagagac aagggtcact tatccgaggg tccctgttcg ggcgccagct gccgcagtcg     1500

gccgacctga gggtcgccgg ggtctgcggg gggaccctct ggaaagtgaa ggataagtga     1560

cgagcggaga cgggatggcg aacagacaca aacacacaag aggtgaatgt taggactgtt     1620

gcaagtttac tcaaaaaatc agcactcttt tatatcttgg tttacataag catttacata     1680

agatttggat aaattccaaa agaacatagg aaaatagaac actcagagct cagatcagaa     1740

cctttgatac caaaccaagt caggaaacca cttgtctcac atcctcgttt taagaacagt     1800

ttgtaaccaa aaacttactt aagccctggg aaccgcaagg ttgggccaat aaaggctatt     1860

cataataact catgccatga gtttttgcag aataatgttc tattagtcca gccactgtcc     1920

cctccttggt atggaaaatc tttccccaaa agtgcattcc tgttcctaga taaatataat     1980

catgtacctg ttgtttcatg tcgtcttttt cttcttgaga caacatacac caaggaggtc     2040

tagctctggc gagtctttca cgaaaaggga gggatctata taacacttta tagccattga     2100

ctgtaaccca cctatcccaa tttaagtcat atcttcctgt atatggtaag ggggcatctg     2160

ttggtctgta gatgtaaggt cccctataag tccctggttg ccaccacctg tctcctattt     2220

tgacaaaaac actctttttt ccctttttta cttctaggcc tgtggtcaat agtccttgca     2280

cctgttcttc aattgaggtt gagcgtctct ttctattttc tattcccatt tctaacttct     2340

gaatttgagt aaaaatagta ctaaaagata atgattcatt tcttaacata gtaactaata     2400

atctacctat tggattggtc ttattggtaa aaatataatt tttagcaagc attcttattt     2460

ctatttctga aggacaaaat cgatgcggct tgtaagagga agttggctgt ggtccttgcc     2520

tcaggaggaa ggtcgagttc tccgaattgt ttagattgta atcttgcaca gaagagctat     2580

taaaagagtc aagggtgaga gccctgcgag cacgaaccgc aacttccccc aatagcccca     2640

ggcaaagcag agctatgcca agtttgcagc agagaatgaa tatgtctttg tctgatgggc     2700

tcatccgttt gtgcgcagac gggtcgtcct tggtgggaaa caaccccttg gctgcttctc     2760

ccctaggtgt aggacactct cgggagttca accatttctg cccaagctca gatctgagct     2820

ttaatgcggt agtttatcac agttaaattg ctaacgcagt caggcaccgt gtatgaaatc     2880

taacaatgcg ctcatcgtca tcctcggcac cgtcaccctg gatgctgtag gcataggctt     2940

ggttatgccg gtactgccgg gcctcttgcg ggatatcgtc cattccgaca gcatcgccag     3000

tcactatggc gtgctgctag cgctcttccg cttcctcgct cactgactcg ctgcgctcgg     3060

tcgttcggct gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag     3120

aatcagggga taacgcagga aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc     3180

gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca     3240

aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt     3300

ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc     3360

tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc     3420

tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc     3480

ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact     3540

tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg     3600

ctacagagtt cttgaagtgg tggcctaact acggctacac tagaaggaca gtatttggta     3660

tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca     3720

aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa     3780

aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct cagtggaacg     3840

aaaactcacg ttaagggatt ttggtcatga gattatcaaa aaggatcttc acctagatcc     3900

ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa acttggtctg     3960

acagttacca atgcttaatc agtgaggcac ctatctcagc gatctgtcta tttcgttcat     4020

ccatagttgc ctgactcccc gtcgtgtaga taactacgat acgggagggc ttaccatctg     4080

gccccagtgc tgcaatgata ccgcgagacc cacgctcacc ggctccagat ttatcagcaa     4140

taaaccagcc agccggaagg gccgagcgca gaagtggtcc tgcaacttta tccgcctcca     4200

tccagtctat taattgttgc cgggaagcta gagtaagtag ttcgccagtt aatagtttgc     4260

gcaacgttgt tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt     4320

cattcagctc cggttcccaa cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa     4380

aagcggttag ctccttcggt cctccgatcg ttgtcagaag taagttggcc gcagtgttat     4440

cactcatggt tatggcagca ctgcataatt ctcttactgt catgccatcc gtaagatgct     4500

tttctgtgac tggtgagtac tcaaccaagt cattctgaga atagtgtatg cggcgaccga     4560

gttgctcttg cccggcgtca acacgggata ataccgcgcc acatagcaga actttaaaag     4620

tgctcatcat tggaaaacgt tcttcggggc gaaaactctc aaggatctta ccgctgttga     4680

gatccagttc gatgtaaccc actcgtgcac ccaactgatc ttcagcatct tttactttca     4740

ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg     4800

cgacacggaa atgttgaata ctcatactct tcctttttca atattattga agcatttatc     4860

agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat aaacaaatag     4920

gggttccgcg cacatttccc cgaaaagtgc cacctgacgt ctaagagacc attattatca     4980

tgacattaac ctataaaaat aggcgtatca cgaggccctt tcgtcttcaa gaattgtcta     5040

gaggcgcgcc gtttaaaccc tcagctgatc atccggatgt acagcgcgcg gccggccggt     5100

accacgcgtt ggccacatat ggcggccgct cgcgattaat taatcgcgat ggccacatat     5160

ggagctctct agagcttgtc gacagatccc cctcttcatt tctttatgtt ttaaatgcac     5220

tgacctccca cattcccttt ttagtaaaat attcagaaat aatttaaata catcattgca     5280

atgaaaataa atgtttttta ttaggcagaa tccagatgct caaggccctt cataatatcc     5340

cccagtttag tagttggact tagggaacaa aggaaccttt aatagaaatt ggacagcaag     5400

aaagcgaggg ggatctggat cctccggagg gccctggatc ctcctacgta tctagaatca     5460

tcgattaaca ctctcccctg ttgaagctct ttgtgacggg cgagctcagg ccctgatggg     5520

tgacttcgca ggcgtagact ttgtgtttct cgtagtctgc tttgctcagc gtcagggtgc     5580

tgctgaggct gtaggtgctg tccttgctgt cctgctctgt gacactctcc tgggagttac     5640

ccgattggag ggcgttatcc accttccact gtactttggc ctctctggga tagaagttat     5700

tcagcaggca cacaacagag gcagttccag atttcaactg ctcatcagat ggcgggaaga     5760

tgaagacaga tggtgcagcc accgtacgtt tgatctccac cttggtccct tggccgaaag     5820

tgtgaggtaa acgactactc tgatgacagt aatacactgc gaaatcttca ggctccagtc     5880

tactgatggt gagggtgaaa tctgtcccag atccactgcc actgaaccta tcggggatcc     5940

ctgagaggga ctgggatgca tacttgatga gaagccttgg agcctgacct ggtttctgct     6000

ggtaccagtg taagctacta ccaatgctct gactggcccg gcaggagagg gtggctctct     6060

cgcctggaga cacagacagg gtacctgggc tctgagtcag cacaatttca cccctggagg     6120

ctggaaccca gagcagcaga aacccaatga gttgtgatgg cgacatggtg gcggcgttta     6180

aacgaattct taagcctgtg gagagaaagg aacagaaaac gaaacaaaga cgtagagttg     6240

agcaagcagg gtcaggcaaa gcgtggagag ccggctgagt ctaggtaggc tccaagggag     6300

cgccggacaa aggcccggtc tcgacctgag ctttaaactt acctgtggcc acacgtgcaa     6360

ttgctatagt gagtcgtatt aatttcgata agccagtaag cagtgggttc tctagttagc     6420

cagagagctc tgcttatata gacctcccac cgtacacgcc taccgcccat ttgcgtcaat     6480

ggggcggagt tgttacgaca ttttggaaag tcccgttgat tttggtgcca aaacaaactc     6540

ccattgacgt caatggggtg gagacttgga aatccccgtg agtcaaaccg ctatccacgc     6600

ccattgatgt actgccaaaa ccgcatcacc atggtaatag cgatgactaa tacgtagatg     6660

tactgccaag taggaaagtc ccataaggtc atgtactggg cataatgcca ggcgggccat     6720

ttaccgtcat tgacgtcaat agggggcgta cttggcatat gatacacttg atgtactgcc     6780

aagtgggcag tttaccgtaa atagtccacc cattgacgtc aatggaaagt ccctattggc     6840

gttactatgg gaacatacgt cattattgac gtcaatgggc gggggtcgtt gggcggtcag     6900

ccaggcgggc catttaccgt aagttatgta acgcggaact ccatatatgg gctatgaact     6960

aatgaccccg taattgatta ctattaataa ctagtcaata atcaatgtca acgcgtatat     7020

ctggcccgta catcggtaac tagtcggacc ggcccgggcc accggtgctc gaagcttgga     7080

tcgatccaga catgataaga tacattgatg agtttggaca aaccacaact agaatgcagt     7140

gaaaaaaatg ctttatttgt gaaatttgtg atgctattgc tttatttgta accattataa     7200

gctgcaataa acaagttaac aacaacaatt gcattcattt tatgtttcag gttcaggggg     7260

aggtgtggga ggttttttaa agcaagtaaa acctctacaa atgtggtatg gctgattatg     7320

atctctagtc aag                                                        7333


<210>  43
<211>  11912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAIG1FRLCb2V1-K plasmid sequence

<400>  43
gcactataca tcaaatattc cttattaacc cctttacaaa ttaaaaagct aaaggtacac       60

aatttttgag catagttatt aatagcagac actctatgcc tgtgtggagt aagaaaaaac      120

agtatgttat gattataact gttatgccta cttataaagg ttacagaata tttttccata      180

attttcttgt atagcagtgc agctttttcc tttgtggtgt aaatagcaaa gcaagcaaga      240

gttctattac taaacacagc atgactcaaa aaacttagca attctgaagg aaagtccttg      300

gggtcttcta cctttctctt cttttttgga ggagtagaat gttgagagtc agcagtagcc      360

tcatcatcac tagatggcat ttcttctgag caaaacaggt tttcctcatt aaaggcattc      420

caccactgct cccattcatc agttccatag gttggaatct aaaatacaca aacaattaga      480

atcagtagtt taacacatta tacacttaaa aattttatat ttaccttaga gctttaaatc      540

tctgtaggta gtttgtccaa ttatgtcaca ccacagaagt aaggttcctt cacaaagatc      600

gatctaaagc cagcaaaagt cccatggtct tataaaaatg catagcttta ggaggggagc      660

agagaacttg aaagcatctt cctgttagtc tttcttctcg tagacttcaa acttatactt      720

gatgcctttt tcctcctgga cctcagagag gacgcctggg tattctggga gaagtttata      780

tttccccaaa tcaatttctg ggaaaaacgt gtcactttca aattcctgca tgatccttgt      840

cacaaagagt ctgaggtggc ctggttgatt catggcttcc tggtaaacag aactgcctcc      900

gactatccaa accatgtcta ctttacttgc caattccggt tgttcaataa gtcttaaggc      960

atcatccaaa cttttggcaa gaaaatgagc tcctcgtggt ggttctttga gttctctact     1020

gagaactata ttaattctgt cctttaaagg tcgattcttc tcaggaatgg agaaccaggt     1080

tttcctaccc ataatcacca gattctgttt accttccact gaagaggttg tggtcattct     1140

ttggaagtac ttgaactcgt tcctgagcgg aggccagggt aggtctccgt tcttgccaat     1200

ccccatattt tgggacacgg cgacgatgca gttcaatggt cgaaccatga tggcagcggg     1260

gataaaatcc taccagcctt cacgctagga ttgccgtcaa gtttggcgcg aaatcgcagc     1320

cctgagctgt cccccccccc aagctcagat ctgagcttgg tccctatggt gagtccgttc     1380

cgctcttgtg atgatagcca gacaagaaag agacaataca agacaaacac caaatagtag     1440

aaatagagac aagggtcact tatccgaggg tccctgttcg ggcgccagct gccgcagtcg     1500

gccgacctga gggtcgccgg ggtctgcggg gggaccctct ggaaagtgaa ggataagtga     1560

cgagcggaga cgggatggcg aacagacaca aacacacaag aggtgaatgt taggactgtt     1620

gcaagtttac tcaaaaaatc agcactcttt tatatcttgg tttacataag catttacata     1680

agatttggat aaattccaaa agaacatagg aaaatagaac actcagagct cagatcagaa     1740

cctttgatac caaaccaagt caggaaacca cttgtctcac atcctcgttt taagaacagt     1800

ttgtaaccaa aaacttactt aagccctggg aaccgcaagg ttgggccaat aaaggctatt     1860

cataataact catgccatga gtttttgcag aataatgttc tattagtcca gccactgtcc     1920

cctccttggt atggaaaatc tttccccaaa agtgcattcc tgttcctaga taaatataat     1980

catgtacctg ttgtttcatg tcgtcttttt cttcttgaga caacatacac caaggaggtc     2040

tagctctggc gagtctttca cgaaaaggga gggatctata taacacttta tagccattga     2100

ctgtaaccca cctatcccaa tttaagtcat atcttcctgt atatggtaag ggggcatctg     2160

ttggtctgta gatgtaaggt cccctataag tccctggttg ccaccacctg tctcctattt     2220

tgacaaaaac actctttttt ccctttttta cttctaggcc tgtggtcaat agtccttgca     2280

cctgttcttc aattgaggtt gagcgtctct ttctattttc tattcccatt tctaacttct     2340

gaatttgagt aaaaatagta ctaaaagata atgattcatt tcttaacata gtaactaata     2400

atctacctat tggattggtc ttattggtaa aaatataatt tttagcaagc attcttattt     2460

ctatttctga aggacaaaat cgatgcggct tgtaagagga agttggctgt ggtccttgcc     2520

tcaggaggaa ggtcgagttc tccgaattgt ttagattgta atcttgcaca gaagagctat     2580

taaaagagtc aagggtgaga gccctgcgag cacgaaccgc aacttccccc aatagcccca     2640

ggcaaagcag agctatgcca agtttgcagc agagaatgaa tatgtctttg tctgatgggc     2700

tcatccgttt gtgcgcagac gggtcgtcct tggtgggaaa caaccccttg gctgcttctc     2760

ccctaggtgt aggacactct cgggagttca accatttctg cccaagctca gatctgagct     2820

ttaatgcggt agtttatcac agttaaattg ctaacgcagt caggcaccgt gtatgaaatc     2880

taacaatgcg ctcatcgtca tcctcggcac cgtcaccctg gatgctgtag gcataggctt     2940

ggttatgccg gtactgccgg gcctcttgcg ggatatcgtc cattccgaca gcatcgccag     3000

tcactatggc gtgctgctag cgctcttccg cttcctcgct cactgactcg ctgcgctcgg     3060

tcgttcggct gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag     3120

aatcagggga taacgcagga aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc     3180

gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca     3240

aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt     3300

ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc     3360

tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc     3420

tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc     3480

ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact     3540

tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg     3600

ctacagagtt cttgaagtgg tggcctaact acggctacac tagaaggaca gtatttggta     3660

tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca     3720

aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa     3780

aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct cagtggaacg     3840

aaaactcacg ttaagggatt ttggtcatga gattatcaaa aaggatcttc acctagatcc     3900

ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa acttggtctg     3960

acagttacca atgcttaatc agtgaggcac ctatctcagc gatctgtcta tttcgttcat     4020

ccatagttgc ctgactcccc gtcgtgtaga taactacgat acgggagggc ttaccatctg     4080

gccccagtgc tgcaatgata ccgcgagacc cacgctcacc ggctccagat ttatcagcaa     4140

taaaccagcc agccggaagg gccgagcgca gaagtggtcc tgcaacttta tccgcctcca     4200

tccagtctat taattgttgc cgggaagcta gagtaagtag ttcgccagtt aatagtttgc     4260

gcaacgttgt tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt     4320

cattcagctc cggttcccaa cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa     4380

aagcggttag ctccttcggt cctccgatcg ttgtcagaag taagttggcc gcagtgttat     4440

cactcatggt tatggcagca ctgcataatt ctcttactgt catgccatcc gtaagatgct     4500

tttctgtgac tggtgagtac tcaaccaagt cattctgaga atagtgtatg cggcgaccga     4560

gttgctcttg cccggcgtca acacgggata ataccgcgcc acatagcaga actttaaaag     4620

tgctcatcat tggaaaacgt tcttcggggc gaaaactctc aaggatctta ccgctgttga     4680

gatccagttc gatgtaaccc actcgtgcac ccaactgatc ttcagcatct tttactttca     4740

ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg     4800

cgacacggaa atgttgaata ctcatactct tcctttttca atattattga agcatttatc     4860

agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat aaacaaatag     4920

gggttccgcg cacatttccc cgaaaagtgc cacctgacgt ctaagagacc attattatca     4980

tgacattaac ctataaaaat aggcgtatca cgaggccctt tcgtcttcaa gaattgtcta     5040

gaggcgcgcc gtttaaaccc tcagctaccg atgtacgggc cagatatacg cgttgacatt     5100

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata     5160

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc     5220

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc     5280

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt     5340

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt     5400

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca     5460

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg     5520

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc     5580

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg     5640

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca     5700

ctgcttactg gcttatcgaa attaatacga ctcactatag caattgcacg tgtggccaca     5760

ggtaagttta aagctcaggt cgagaccggg cctttgtccg gcgctccctt ggagcctacc     5820

tagactcagc cggctctcca cgctttgcct gaccctgctt gctcaactct acgtctttgt     5880

ttcgttttct gttcctttct ctccacaggc ttaagcttgg taccgccgcc accatggagt     5940

ttgggctgag ctgggttttc cttgttgcta tattaaaagg tgtccagtgt gaggttcagc     6000

tggtgcagtc tgggggaggc ttggtaaagc ctggggggtc cctgagactc tcctgtgcag     6060

cctctggatt caccttcagt agctttgcta tgcactgggt tcgccaggct ccaggaaaag     6120

gtctggagtg gatatcagtt attgatactc gtggtgccac atactatgca gactccgtga     6180

agggccgatt caccatctcc agagacaatg ccaagaactc cttgtatctt caaatgaaca     6240

gcctgagagc cgaggacact gctgtgtatt actgtgcaag actggggaac ttctactacg     6300

gtatggacgt ctggggccaa gggaccacgg tcaccgtctc ctcagcttcc accaagggcc     6360

catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca gcggccctgg     6420

gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac tcaggcgccc     6480

tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc tactccctca     6540

gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc tgcaacgtga     6600

atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct tgtgacaaaa     6660

ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca gtcttcctct     6720

tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc acatgcgtgg     6780

tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg     6840

aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg taccgtgtgg     6900

tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac aagtgcaagg     6960

tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc aaagggcagc     7020

cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc aagaaccagg     7080

tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg gagtgggaga     7140

gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac tccgacggct     7200

ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag gggaacgtct     7260

tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag agcctctccc     7320

tgtctccggg taaatgaatc gatgattcta gatacgggtc cggaggatcc agatccccct     7380

cgctttcttg ctgtccaatt tctattaaag gttcctttgt tccctaagtc caactactaa     7440

actgggggat attatgaagg gccttgagca tctggattct gcctaataaa aaacatttat     7500

tttcattgca atgatgtatt taaattattt ctgaatattt tactaaaaag ggaatgtggg     7560

aggtcagtgc atttaaaaca taaagaaatg aagaggggga tctgtcgaca agctctagag     7620

agctcacgcg ttgatcatgt acaggccggc caagctttcg actagcttgg cacgccagaa     7680

atccgcgcgg tggtttttgg gggtcggggg tgtttggcag ccacagacgc ccggtgttcg     7740

tgtcgcgcca gtacatgcgg tccatgccca ggccatccaa aaaccatggg tctgtctgct     7800

cagtccagtc gtggacctga ccccacgcaa cgcccaaaat aataaccccc acgaaccata     7860

aaccattccc catgggggac cccgtcccta acccacgggg ccagtggcta tggcagggcc     7920

tgccgccccg acgttggctg cgagccctgg gccttcaccc gaacttgggg ggtggggtgg     7980

ggaaaaggaa gaaacgcggg cgtattggcc ccaatggggt ctcggtgggg tatcgacaga     8040

gtgccagccc tgggaccgaa ccccgcgttt atgaacaaac gacccaacac ccgtgcgttt     8100

tattctgtct ttttattgcc gtcatagcgc gggttccttc cggtattgtc tccttccgtg     8160

tttcagttag cctcccccat ctcccgatcc ggacgagtgc tggggcgtcg gtttccacta     8220

tcggcgagta cttctacaca gccatcggtc cagacggccg cgcttctgcg ggcgatttgt     8280

gtacgcccga cagtcccggc tccggatcgg acgattgcgt cgcatcgacc ctgcgcccaa     8340

gctgcatcat cgaaattgcc gtcaaccaag ctctgataga gttggtcaag accaatgcgg     8400

agcatatacg cccggagccg cggcgatcct gcaagctccg gatgcctccg ctcgaagtag     8460

cgcgtctgct gctccataca agccaaccac ggcctccaga agaagatgtt ggcgacctcg     8520

tattgggaat ccccgaacat cgcctcgctc cagtcaatga ccgctgttat gcggccattg     8580

tccgtcagga cattgttgga gccgaaatcc gcgtgcacga ggtgccggac ttcggggcag     8640

tcctcggccc aaagcatcag ctcatcgaga gcctgcgcga cggacgcact gacggtgtcg     8700

tccatcacag tttgccagtg atacacatgg ggatcagcaa tcgcgcatat gaaatcacgc     8760

catgtagtgt attgaccgat tccttgcggt ccgaatgggc cgaacccgct cgtctggcta     8820

agatcggccg cagcgatcgc atccatggcc tccgcgaccg gctgcagaac agcgggcagt     8880

tcggtttcag gcaggtcttg caacgtgaca ccctgtgcac ggcgggagat gcaataggtc     8940

aggctctcgc tgaattcccc aatgtcaagc acttccggaa tcgggagcgc ggccgatgca     9000

aagtgccgat aaacataacg atctttgtag aaaccatcgg cgcagctatt tacccgcagg     9060

acatatccac gccctcctac atcgaagctg aaagcacgag attcttcgcc ctccgagagc     9120

tgcatcaggt cggagacgct gtcgaacttt tcgatcagaa acttctcgac agacgtcgcg     9180

gtgagttcag gctttttcat atctcattgc cccccgggat ctgcggcacg ctgttgacgc     9240

tgttaagcgg gtcgctgcag ggtcgctcgg tgttcgaggc cacacgcgtc accttaatat     9300

gcgaagtgga cctcggaccg cgccgccccg actgcatctg cgtgttcgaa ttcgccaatg     9360

acaagacgct gggcggggtt tgtgtcatca tagaactaaa gacatgcaaa tatatttctt     9420

ccggggacac cgccagcaaa cgcgagcaac gggccacggg gatgaagcag ggcggcacct     9480

cgctaacgga ttcaccactc caagaattgg agccaatcaa ttcttgcgga gaactgtgaa     9540

tgcgcaaacc aacccttggc agaacatatc catcgcgtcc gccatctcca gcagccgcac     9600

gcggcgcatc tcggggccga cgcgctgggc tacgtcttgc tggcgttcgc acaggccggc     9660

cagcgcgcgg ccggccggta ccacgcgttg gccacatatg gcggccgctc gcgattaatt     9720

aatcgcgatg gccacatatg gagctctcta gagcttgtcg acagatcccc ctcttcattt     9780

ctttatgttt taaatgcact gacctcccac attccctttt tagtaaaata ttcagaaata     9840

atttaaatac atcattgcaa tgaaaataaa tgttttttat taggcagaat ccagatgctc     9900

aaggcccttc ataatatccc ccagtttagt agttggactt agggaacaaa ggaaccttta     9960

atagaaattg gacagcaaga aagcgagggg gatctggatc ctccggaggg ccctggatcc    10020

tcctacgtat ctagaatcat cgattaacac tctcccctgt tgaagctctt tgtgacgggc    10080

gagctcaggc cctgatgggt gacttcgcag gcgtagactt tgtgtttctc gtagtctgct    10140

ttgctcagcg tcagggtgct gctgaggctg taggtgctgt ccttgctgtc ctgctctgtg    10200

acactctcct gggagttacc cgattggagg gcgttatcca ccttccactg tactttggcc    10260

tctctgggat agaagttatt cagcaggcac acaacagagg cagttccaga tttcaactgc    10320

tcatcagatg gcgggaagat gaagacagat ggtgcagcca ccgtacgttt gatctccacc    10380

ttggtccctt ggccgaaagt gtgaggtaaa cgactactct gatgacagta atacactgcg    10440

aaatcttcag gctccagtct actgatggtg agggtgaaat ctgtcccaga tccactgcca    10500

ctgaacctat cggggatccc tgagagggac tgggatgcat acttgatgag aagccttgga    10560

gcctgacctg gtttctgctg gtaccagtgt aagctactac caatgctctg actggcccgg    10620

caggagaggg tggctctctc gcctggagac acagacaggg tacctgggct ctgagtcagc    10680

acaatttcac ccctggaggc tggaacccag agcagcagaa acccaatgag ttgtgatggc    10740

gacatggtgg cggcgtttaa acgaattctt aagcctgtgg agagaaagga acagaaaacg    10800

aaacaaagac gtagagttga gcaagcaggg tcaggcaaag cgtggagagc cggctgagtc    10860

taggtaggct ccaagggagc gccggacaaa ggcccggtct cgacctgagc tttaaactta    10920

cctgtggcca cacgtgcaat tgctatagtg agtcgtatta atttcgataa gccagtaagc    10980

agtgggttct ctagttagcc agagagctct gcttatatag acctcccacc gtacacgcct    11040

accgcccatt tgcgtcaatg gggcggagtt gttacgacat tttggaaagt cccgttgatt    11100

ttggtgccaa aacaaactcc cattgacgtc aatggggtgg agacttggaa atccccgtga    11160

gtcaaaccgc tatccacgcc cattgatgta ctgccaaaac cgcatcacca tggtaatagc    11220

gatgactaat acgtagatgt actgccaagt aggaaagtcc cataaggtca tgtactgggc    11280

ataatgccag gcgggccatt taccgtcatt gacgtcaata gggggcgtac ttggcatatg    11340

atacacttga tgtactgcca agtgggcagt ttaccgtaaa tagtccaccc attgacgtca    11400

atggaaagtc cctattggcg ttactatggg aacatacgtc attattgacg tcaatgggcg    11460

ggggtcgttg ggcggtcagc caggcgggcc atttaccgta agttatgtaa cgcggaactc    11520

catatatggg ctatgaacta atgaccccgt aattgattac tattaataac tagtcaataa    11580

tcaatgtcaa cgcgtatatc tggcccgtac atcggtaact agtcggaccg gcccgggcca    11640

ccggtgctcg aagcttggat cgatccagac atgataagat acattgatga gtttggacaa    11700

accacaacta gaatgcagtg aaaaaaatgc tttatttgtg aaatttgtga tgctattgct    11760

ttatttgtaa ccattataag ctgcaataaa caagttaaca acaacaattg cattcatttt    11820

atgtttcagg ttcaggggga ggtgtgggag gttttttaaa gcaagtaaaa cctctacaaa    11880

tgtggtatgg ctgattatga tctctagtca ag                                  11912


<210>  44
<211>  11893
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAIL23V1-K plasmid sequence

<400>  44
ggcactatac atcaaatatt ccttattaac ccctttacaa attaaaaagc taaaggtaca       60

caatttttga gcatagttat taatagcaga cactctatgc ctgtgtggag taagaaaaaa      120

cagtatgtta tgattataac tgttatgcct acttataaag gttacagaat atttttccat      180

aattttcttg tatagcagtg cagctttttc ctttgtggtg taaatagcaa agcaagcaag      240

agttctatta ctaaacacag catgactcaa aaaacttagc aattctgaag gaaagtcctt      300

ggggtcttct acctttctct tcttttttgg aggagtagaa tgttgagagt cagcagtagc      360

ctcatcatca ctagatggca tttcttctga gcaaaacagg ttttcctcat taaaggcatt      420

ccaccactgc tcccattcat cagttccata ggttggaatc taaaatacac aaacaattag      480

aatcagtagt ttaacacatt atacacttaa aaattttata tttaccttag agctttaaat      540

ctctgtaggt agtttgtcca attatgtcac accacagaag taaggttcct tcacaaagat      600

cgatctaaag ccagcaaaag tcccatggtc ttataaaaat gcatagcttt aggaggggag      660

cagagaactt gaaagcatct tcctgttagt ctttcttctc gtagacttca aacttatact      720

tgatgccttt ttcctcctgg acctcagaga ggacgcctgg gtattctggg agaagtttat      780

atttccccaa atcaatttct gggaaaaacg tgtcactttc aaattcctgc atgatccttg      840

tcacaaagag tctgaggtgg cctggttgat tcatggcttc ctggtaaaca gaactgcctc      900

cgactatcca aaccatgtct actttacttg ccaattccgg ttgttcaata agtcttaagg      960

catcatccaa acttttggca agaaaatgag ctcctcgtgg tggttctttg agttctctac     1020

tgagaactat attaattctg tcctttaaag gtcgattctt ctcaggaatg gagaaccagg     1080

ttttcctacc cataatcacc agattctgtt taccttccac tgaagaggtt gtggtcattc     1140

tttggaagta cttgaactcg ttcctgagcg gaggccaggg taggtctccg ttcttgccaa     1200

tccccatatt ttgggacacg gcgacgatgc agttcaatgg tcgaaccatg atggcagcgg     1260

ggataaaatc ctaccagcct tcacgctagg attgccgtca agtttggcgc gaaatcgcag     1320

ccctgagctg tccccccccc caagctcaga tctgagcttg gtccctatgg tgagtccgtt     1380

ccgctcttgt gatgatagcc agacaagaaa gagacaatac aagacaaaca ccaaatagta     1440

gaaatagaga caagggtcac ttatccgagg gtccctgttc gggcgccagc tgccgcagtc     1500

ggccgacctg agggtcgccg gggtctgcgg ggggaccctc tggaaagtga aggataagtg     1560

acgagcggag acgggatggc gaacagacac aaacacacaa gaggtgaatg ttaggactgt     1620

tgcaagttta ctcaaaaaat cagcactctt ttatatcttg gtttacataa gcatttacat     1680

aagatttgga taaattccaa aagaacatag gaaaatagaa cactcagagc tcagatcaga     1740

acctttgata ccaaaccaag tcaggaaacc acttgtctca catcctcgtt ttaagaacag     1800

tttgtaacca aaaacttact taagccctgg gaaccgcaag gttgggccaa taaaggctat     1860

tcataataac tcatgccatg agtttttgca gaataatgtt ctattagtcc agccactgtc     1920

ccctccttgg tatggaaaat ctttccccaa aagtgcattc ctgttcctag ataaatataa     1980

tcatgtacct gttgtttcat gtcgtctttt tcttcttgag acaacataca ccaaggaggt     2040

ctagctctgg cgagtctttc acgaaaaggg agggatctat ataacacttt atagccattg     2100

actgtaaccc acctatccca atttaagtca tatcttcctg tatatggtaa gggggcatct     2160

gttggtctgt agatgtaagg tcccctataa gtccctggtt gccaccacct gtctcctatt     2220

ttgacaaaaa cactcttttt tccctttttt acttctaggc ctgtggtcaa tagtccttgc     2280

acctgttctt caattgaggt tgagcgtctc tttctatttt ctattcccat ttctaacttc     2340

tgaatttgag taaaaatagt actaaaagat aatgattcat ttcttaacat agtaactaat     2400

aatctaccta ttggattggt cttattggta aaaatataat ttttagcaag cattcttatt     2460

tctatttctg aaggacaaaa tcgatgcggc ttgtaagagg aagttggctg tggtccttgc     2520

ctcaggagga aggtcgagtt ctccgaattg tttagattgt aatcttgcac agaagagcta     2580

ttaaaagagt caagggtgag agccctgcga gcacgaaccg caacttcccc caatagcccc     2640

aggcaaagca gagctatgcc aagtttgcag cagagaatga atatgtcttt gtctgatggg     2700

ctcatccgtt tgtgcgcaga cgggtcgtcc ttggtgggaa acaacccctt ggctgcttct     2760

cccctaggtg taggacactc tcgggagttc aaccatttct gcccaagctc agatctgagc     2820

tttaatgcgg tagtttatca cagttaaatt gctaacgcag tcaggcaccg tgtatgaaat     2880

ctaacaatgc gctcatcgtc atcctcggca ccgtcaccct ggatgctgta ggcataggct     2940

tggttatgcc ggtactgccg ggcctcttgc gggatatcgt ccattccgac agcatcgcca     3000

gtcactatgg cgtgctgcta gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg     3060

gtcgttcggc tgcggcgagc ggtatcagct cactcaaagg cggtaatacg gttatccaca     3120

gaatcagggg ataacgcagg aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac     3180

cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc gcccccctga cgagcatcac     3240

aaaaatcgac gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg     3300

tttccccctg gaagctccct cgtgcgctct cctgttccga ccctgccgct taccggatac     3360

ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc atagctcacg ctgtaggtat     3420

ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag     3480

cccgaccgct gcgccttatc cggtaactat cgtcttgagt ccaacccggt aagacacgac     3540

ttatcgccac tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt     3600

gctacagagt tcttgaagtg gtggcctaac tacggctaca ctagaaggac agtatttggt     3660

atctgcgctc tgctgaagcc agttaccttc ggaaaaagag ttggtagctc ttgatccggc     3720

aaacaaacca ccgctggtag cggtggtttt tttgtttgca agcagcagat tacgcgcaga     3780

aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc tcagtggaac     3840

gaaaactcac gttaagggat tttggtcatg agattatcaa aaaggatctt cacctagatc     3900

cttttaaatt aaaaatgaag ttttaaatca atctaaagta tatatgagta aacttggtct     3960

gacagttacc aatgcttaat cagtgaggca cctatctcag cgatctgtct atttcgttca     4020

tccatagttg cctgactccc cgtcgtgtag ataactacga tacgggaggg cttaccatct     4080

ggccccagtg ctgcaatgat accgcgagac ccacgctcac cggctccaga tttatcagca     4140

ataaaccagc cagccggaag ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc     4200

atccagtcta ttaattgttg ccgggaagct agagtaagta gttcgccagt taatagtttg     4260

cgcaacgttg ttgccattgc tacaggcatc gtggtgtcac gctcgtcgtt tggtatggct     4320

tcattcagct ccggttccca acgatcaagg cgagttacat gatcccccat gttgtgcaaa     4380

aaagcggtta gctccttcgg tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta     4440

tcactcatgg ttatggcagc actgcataat tctcttactg tcatgccatc cgtaagatgc     4500

ttttctgtga ctggtgagta ctcaaccaag tcattctgag aatagtgtat gcggcgaccg     4560

agttgctctt gcccggcgtc aacacgggat aataccgcgc cacatagcag aactttaaaa     4620

gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct caaggatctt accgctgttg     4680

agatccagtt cgatgtaacc cactcgtgca cccaactgat cttcagcatc ttttactttc     4740

accagcgttt ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg     4800

gcgacacgga aatgttgaat actcatactc ttcctttttc aatattattg aagcatttat     4860

cagggttatt gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata     4920

ggggttccgc gcacatttcc ccgaaaagtg ccacctgacg tctaagagac cattattatc     4980

atgacattaa cctataaaaa taggcgtatc acgaggccct ttcgtcttca agaattgtct     5040

agaggcgcgc cgtttaaacc ctcagctacc gatgtacggg ccagatatac gcgttgacat     5100

tgattattga ctagttatta atagtaatca attacggggt cattagttca tagcccatat     5160

atggagttcc gcgttacata acttacggta aatggcccgc ctggctgacc gcccaacgac     5220

ccccgcccat tgacgtcaat aatgacgtat gttcccatag taacgccaat agggactttc     5280

cattgacgtc aatgggtgga ctatttacgg taaactgccc acttggcagt acatcaagtg     5340

tatcatatgc caagtacgcc ccctattgac gtcaatgacg gtaaatggcc cgcctggcat     5400

tatgcccagt acatgacctt atgggacttt cctacttggc agtacatcta cgtattagtc     5460

atcgctatta ccatggtgat gcggttttgg cagtacatca atgggcgtgg atagcggttt     5520

gactcacggg gatttccaag tctccacccc attgacgtca atgggagttt gttttggcac     5580

caaaatcaac gggactttcc aaaatgtcgt aacaactccg ccccattgac gcaaatgggc     5640

ggtaggcgtg tacggtggga ggtctatata agcagagctc tctggctaac tagagaaccc     5700

actgcttact ggcttatcga aattaatacg actcactata gcaattgcac gtgtggccac     5760

aggtaagttt aaagctcagg tcgagaccgg gcctttgtcc ggcgctccct tggagcctac     5820

ctagactcag ccggctctcc acgctttgcc tgaccctgct tgctcaactc tacgtctttg     5880

tttcgttttc tgttcctttc tctccacagg cttaagctcg aggccgccac catggctgtg     5940

ctggggctgc tgttctgcct ggtgacattc ccaagctgtg tgctgtccca ggtgcagctg     6000

gtgcagtctg gcgctgaggt gaagaagcct ggcgcctccg tgaaggtctc ctgcaaggct     6060

tctggctaca tcttcatcac ctactggatg acctgggtgc ggcaggcccc tggccagggg     6120

ctggagtgga tgggccagat cttccctgcc agcggctctg cagactacaa cgagaagttc     6180

gaaggcagag tcaccatgac cacagacaca tccaccagca cagcctacat ggagctgagg     6240

agcctgagat ctgacgacac cgccgtgtat tactgtgcca gaggcggtgg cggattcgct     6300

tactggggcc agggcaccct ggtcaccgtc tccagcgcta gcaccaaggg cccatcggtc     6360

ttccccctgg caccctcctc caagagcacc tctgggggca cagcggccct gggctgcctg     6420

gtcaaggact acttccccga accggtgacg gtgtcgtgga actcaggcgc cctgaccagc     6480

ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac tctactccct cagcagcgtg     6540

gtgaccgtgc cctccagcag cttgggcacc cagacctaca tctgcaacgt gaatcacaag     6600

cccagcaaca ccaaggtgga caagaaagtt gagcccaaat cttgtgacaa aactcacaca     6660

tgcccaccgt gcccagcacc tgaactcctg gggggaccgt cagtcttcct cttcccccca     6720

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac     6780

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat     6840

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc     6900

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac     6960

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa     7020

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg     7080

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg     7140

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     7200

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc     7260

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg     7320

ggtaaatgaa tcgatgattc tagatacggg tccggaggat ccagatcccc ctcgctttct     7380

tgctgtccaa tttctattaa aggttccttt gttccctaag tccaactact aaactggggg     7440

atattatgaa gggccttgag catctggatt ctgcctaata aaaaacattt attttcattg     7500

caatgatgta tttaaattat ttctgaatat tttactaaaa agggaatgtg ggaggtcagt     7560

gcatttaaaa cataaagaaa tgaagagggg gatctgtcga caagctctag agagctcacg     7620

cgttgatcat gtacaggccg gccaagcttt cgactagctt ggcacgccag aaatccgcgc     7680

ggtggttttt gggggtcggg ggtgtttggc agccacagac gcccggtgtt cgtgtcgcgc     7740

cagtacatgc ggtccatgcc caggccatcc aaaaaccatg ggtctgtctg ctcagtccag     7800

tcgtggacct gaccccacgc aacgcccaaa ataataaccc ccacgaacca taaaccattc     7860

cccatggggg accccgtccc taacccacgg ggccagtggc tatggcaggg cctgccgccc     7920

cgacgttggc tgcgagccct gggccttcac ccgaacttgg ggggtggggt ggggaaaagg     7980

aagaaacgcg ggcgtattgg ccccaatggg gtctcggtgg ggtatcgaca gagtgccagc     8040

cctgggaccg aaccccgcgt ttatgaacaa acgacccaac acccgtgcgt tttattctgt     8100

ctttttattg ccgtcatagc gcgggttcct tccggtattg tctccttccg tgtttcagtt     8160

agcctccccc atctcccgat ccggacgagt gctggggcgt cggtttccac tatcggcgag     8220

tacttctaca cagccatcgg tccagacggc cgcgcttctg cgggcgattt gtgtacgccc     8280

gacagtcccg gctccggatc ggacgattgc gtcgcatcga ccctgcgccc aagctgcatc     8340

atcgaaattg ccgtcaacca agctctgata gagttggtca agaccaatgc ggagcatata     8400

cgcccggagc cgcggcgatc ctgcaagctc cggatgcctc cgctcgaagt agcgcgtctg     8460

ctgctccata caagccaacc acggcctcca gaagaagatg ttggcgacct cgtattggga     8520

atccccgaac atcgcctcgc tccagtcaat gaccgctgtt atgcggccat tgtccgtcag     8580

gacattgttg gagccgaaat ccgcgtgcac gaggtgccgg acttcggggc agtcctcggc     8640

ccaaagcatc agctcatcga gagcctgcgc gacggacgca ctgacggtgt cgtccatcac     8700

agtttgccag tgatacacat ggggatcagc aatcgcgcat atgaaatcac gccatgtagt     8760

gtattgaccg attccttgcg gtccgaatgg gccgaacccg ctcgtctggc taagatcggc     8820

cgcagcgatc gcatccatgg cctccgcgac cggctgcaga acagcgggca gttcggtttc     8880

aggcaggtct tgcaacgtga caccctgtgc acggcgggag atgcaatagg tcaggctctc     8940

gctgaattcc ccaatgtcaa gcacttccgg aatcgggagc gcggccgatg caaagtgccg     9000

ataaacataa cgatctttgt agaaaccatc ggcgcagcta tttacccgca ggacatatcc     9060

acgccctcct acatcgaagc tgaaagcacg agattcttcg ccctccgaga gctgcatcag     9120

gtcggagacg ctgtcgaact tttcgatcag aaacttctcg acagacgtcg cggtgagttc     9180

aggctttttc atatctcatt gccccccggg atctgcggca cgctgttgac gctgttaagc     9240

gggtcgctgc agggtcgctc ggtgttcgag gccacacgcg tcaccttaat atgcgaagtg     9300

gacctcggac cgcgccgccc cgactgcatc tgcgtgttcg aattcgccaa tgacaagacg     9360

ctgggcgggg tttgtgtcat catagaacta aagacatgca aatatatttc ttccggggac     9420

accgccagca aacgcgagca acgggccacg gggatgaagc agggcggcac ctcgctaacg     9480

gattcaccac tccaagaatt ggagccaatc aattcttgcg gagaactgtg aatgcgcaaa     9540

ccaacccttg gcagaacata tccatcgcgt ccgccatctc cagcagccgc acgcggcgca     9600

tctcggggcc gacgcgctgg gctacgtctt gctggcgttc gcacaggccg gccagcgcgc     9660

ggccggccgg taccacgcgt tggccacata tggcggccgc tcgcgattaa ttaatcgcga     9720

tggccacata tggagctctc tagagcttgt cgacagatcc ccctcttcat ttctttatgt     9780

tttaaatgca ctgacctccc acattccctt tttagtaaaa tattcagaaa taatttaaat     9840

acatcattgc aatgaaaata aatgtttttt attaggcaga atccagatgc tcaaggccct     9900

tcataatatc ccccagttta gtagttggac ttagggaaca aaggaacctt taatagaaat     9960

tggacagcaa gaaagcgagg gggatctgga tcctcctacg tatctagaat catcgattaa    10020

cactctcccc tgttgaagct ctttgtcacg gggctgctca ggccctgatg ggtcacctcg    10080

caggcgtaca ccttgtgttt ctcgtagtct gctttgctca gggtcagggt gctgctcagg    10140

ctgtaggtgc tgtccttgct gtcctgctct gtcacgctct cctgggagtt gccgctctgg    10200

agggcgttat ccaccttcca ctgcaccttg gcctctctgg gatagaagtt attcagcagg    10260

cacaccacgg aggcagttcc agacttcagc tgctcatcag atggagggaa gatgaacaca    10320

gatggtgcag ccaccgtacg cttgatctcc accttggtgc cctggccgaa ggtgaatgga    10380

attccgtagt ggtgctgaca gtagtaggtg gcgaagtcct caggctgcag gctgctgatg    10440

gtcagggtga agtctgtccc agagccgctg ccgctgaacc tggatggcac cccttcagcc    10500

agggtcttgg cgttatagat cagcagctta ggggccttcc ctggcttctg ctgataccag    10560

gccaggtagc tgtagatgtt ctcgctggtc ctgcaggtga tggtcactct gtcgcccaca    10620

gaggcagaca gggaggatgg agactgggtc atctggatat cacatctcat ggctggcagg    10680

aacagcacca gcagccccag cagctgcact ggagccatgg tggcggcctc gagaagctta    10740

agtttaattc ttaagcctgt ggagagaaag gaacagaaaa cgaaacaaag acgtagagtt    10800

gagcaagcag ggtcaggcaa agcgtggaga gccggctgag tctaggtagg ctccaaggga    10860

gcgccggaca aaggcccggt ctcgacctga gctttaaact tacctgtggc cacacgtgca    10920

attgctatag tgagtcgtat taatttcgat aagccagtaa gcagtgggtt ctctagttag    10980

ccagagagct ctgcttatat agacctccca ccgtacacgc ctaccgccca tttgcgtcaa    11040

tggggcggag ttgttacgac attttggaaa gtcccgttga ttttggtgcc aaaacaaact    11100

cccattgacg tcaatggggt ggagacttgg aaatccccgt gagtcaaacc gctatccacg    11160

cccattgatg tactgccaaa accgcatcac catggtaata gcgatgacta atacgtagat    11220

gtactgccaa gtaggaaagt cccataaggt catgtactgg gcataatgcc aggcgggcca    11280

tttaccgtca ttgacgtcaa tagggggcgt acttggcata tgatacactt gatgtactgc    11340

caagtgggca gtttaccgta aatagtccac ccattgacgt caatggaaag tccctattgg    11400

cgttactatg ggaacatacg tcattattga cgtcaatggg cgggggtcgt tgggcggtca    11460

gccaggcggg ccatttaccg taagttatgt aacgcggaac tccatatatg ggctatgaac    11520

taatgacccc gtaattgatt actattaata actagtcaat aatcaatgtc aacgcgtata    11580

tctggcccgt acatcggtaa ctagtcggac cggcccgggc caccggtgct cgaagcttgg    11640

atcgatccag acatgataag atacattgat gagtttggac aaaccacaac tagaatgcag    11700

tgaaaaaaat gctttatttg tgaaatttgt gatgctattg ctttatttgt aaccattata    11760

agctgcaata aacaagttaa caacaacaat tgcattcatt ttatgtttca ggttcagggg    11820

gaggtgtggg aggtttttta aagcaagtaa aacctctaca aatgtggtat ggctgattat    11880

gatctctagt caa                                                       11893


<210>  45
<211>  11901
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAIL23RV1 plasmid sequence

<400>  45
ggcactatac atcaaatatt ccttattaac ccctttacaa attaaaaagc taaaggtaca       60

caatttttga gcatagttat taatagcaga cactctatgc ctgtgtggag taagaaaaaa      120

cagtatgtta tgattataac tgttatgcct acttataaag gttacagaat atttttccat      180

aattttcttg tatagcagtg cagctttttc ctttgtggtg taaatagcaa agcaagcaag      240

agttctatta ctaaacacag catgactcaa aaaacttagc aattctgaag gaaagtcctt      300

ggggtcttct acctttctct tcttttttgg aggagtagaa tgttgagagt cagcagtagc      360

ctcatcatca ctagatggca tttcttctga gcaaaacagg ttttcctcat taaaggcatt      420

ccaccactgc tcccattcat cagttccata ggttggaatc taaaatacac aaacaattag      480

aatcagtagt ttaacacatt atacacttaa aaattttata tttaccttag agctttaaat      540

ctctgtaggt agtttgtcca attatgtcac accacagaag taaggttcct tcacaaagat      600

cgatctaaag ccagcaaaag tcccatggtc ttataaaaat gcatagcttt aggaggggag      660

cagagaactt gaaagcatct tcctgttagt ctttcttctc gtagacttca aacttatact      720

tgatgccttt ttcctcctgg acctcagaga ggacgcctgg gtattctggg agaagtttat      780

atttccccaa atcaatttct gggaaaaacg tgtcactttc aaattcctgc atgatccttg      840

tcacaaagag tctgaggtgg cctggttgat tcatggcttc ctggtaaaca gaactgcctc      900

cgactatcca aaccatgtct actttacttg ccaattccgg ttgttcaata agtcttaagg      960

catcatccaa acttttggca agaaaatgag ctcctcgtgg tggttctttg agttctctac     1020

tgagaactat attaattctg tcctttaaag gtcgattctt ctcaggaatg gagaaccagg     1080

ttttcctacc cataatcacc agattctgtt taccttccac tgaagaggtt gtggtcattc     1140

tttggaagta cttgaactcg ttcctgagcg gaggccaggg taggtctccg ttcttgccaa     1200

tccccatatt ttgggacacg gcgacgatgc agttcaatgg tcgaaccatg atggcagcgg     1260

ggataaaatc ctaccagcct tcacgctagg attgccgtca agtttggcgc gaaatcgcag     1320

ccctgagctg tccccccccc caagctcaga tctgagcttg gtccctatgg tgagtccgtt     1380

ccgctcttgt gatgatagcc agacaagaaa gagacaatac aagacaaaca ccaaatagta     1440

gaaatagaga caagggtcac ttatccgagg gtccctgttc gggcgccagc tgccgcagtc     1500

ggccgacctg agggtcgccg gggtctgcgg ggggaccctc tggaaagtga aggataagtg     1560

acgagcggag acgggatggc gaacagacac aaacacacaa gaggtgaatg ttaggactgt     1620

tgcaagttta ctcaaaaaat cagcactctt ttatatcttg gtttacataa gcatttacat     1680

aagatttgga taaattccaa aagaacatag gaaaatagaa cactcagagc tcagatcaga     1740

acctttgata ccaaaccaag tcaggaaacc acttgtctca catcctcgtt ttaagaacag     1800

tttgtaacca aaaacttact taagccctgg gaaccgcaag gttgggccaa taaaggctat     1860

tcataataac tcatgccatg agtttttgca gaataatgtt ctattagtcc agccactgtc     1920

ccctccttgg tatggaaaat ctttccccaa aagtgcattc ctgttcctag ataaatataa     1980

tcatgtacct gttgtttcat gtcgtctttt tcttcttgag acaacataca ccaaggaggt     2040

ctagctctgg cgagtctttc acgaaaaggg agggatctat ataacacttt atagccattg     2100

actgtaaccc acctatccca atttaagtca tatcttcctg tatatggtaa gggggcatct     2160

gttggtctgt agatgtaagg tcccctataa gtccctggtt gccaccacct gtctcctatt     2220

ttgacaaaaa cactcttttt tccctttttt acttctaggc ctgtggtcaa tagtccttgc     2280

acctgttctt caattgaggt tgagcgtctc tttctatttt ctattcccat ttctaacttc     2340

tgaatttgag taaaaatagt actaaaagat aatgattcat ttcttaacat agtaactaat     2400

aatctaccta ttggattggt cttattggta aaaatataat ttttagcaag cattcttatt     2460

tctatttctg aaggacaaaa tcgatgcggc ttgtaagagg aagttggctg tggtccttgc     2520

ctcaggagga aggtcgagtt ctccgaattg tttagattgt aatcttgcac agaagagcta     2580

ttaaaagagt caagggtgag agccctgcga gcacgaaccg caacttcccc caatagcccc     2640

aggcaaagca gagctatgcc aagtttgcag cagagaatga atatgtcttt gtctgatggg     2700

ctcatccgtt tgtgcgcaga cgggtcgtcc ttggtgggaa acaacccctt ggctgcttct     2760

cccctaggtg taggacactc tcgggagttc aaccatttct gcccaagctc agatctgagc     2820

tttaatgcgg tagtttatca cagttaaatt gctaacgcag tcaggcaccg tgtatgaaat     2880

ctaacaatgc gctcatcgtc atcctcggca ccgtcaccct ggatgctgta ggcataggct     2940

tggttatgcc ggtactgccg ggcctcttgc gggatatcgt ccattccgac agcatcgcca     3000

gtcactatgg cgtgctgcta gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg     3060

gtcgttcggc tgcggcgagc ggtatcagct cactcaaagg cggtaatacg gttatccaca     3120

gaatcagggg ataacgcagg aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac     3180

cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc gcccccctga cgagcatcac     3240

aaaaatcgac gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg     3300

tttccccctg gaagctccct cgtgcgctct cctgttccga ccctgccgct taccggatac     3360

ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc atagctcacg ctgtaggtat     3420

ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag     3480

cccgaccgct gcgccttatc cggtaactat cgtcttgagt ccaacccggt aagacacgac     3540

ttatcgccac tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt     3600

gctacagagt tcttgaagtg gtggcctaac tacggctaca ctagaaggac agtatttggt     3660

atctgcgctc tgctgaagcc agttaccttc ggaaaaagag ttggtagctc ttgatccggc     3720

aaacaaacca ccgctggtag cggtggtttt tttgtttgca agcagcagat tacgcgcaga     3780

aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc tcagtggaac     3840

gaaaactcac gttaagggat tttggtcatg agattatcaa aaaggatctt cacctagatc     3900

cttttaaatt aaaaatgaag ttttaaatca atctaaagta tatatgagta aacttggtct     3960

gacagttacc aatgcttaat cagtgaggca cctatctcag cgatctgtct atttcgttca     4020

tccatagttg cctgactccc cgtcgtgtag ataactacga tacgggaggg cttaccatct     4080

ggccccagtg ctgcaatgat accgcgagac ccacgctcac cggctccaga tttatcagca     4140

ataaaccagc cagccggaag ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc     4200

atccagtcta ttaattgttg ccgggaagct agagtaagta gttcgccagt taatagtttg     4260

cgcaacgttg ttgccattgc tacaggcatc gtggtgtcac gctcgtcgtt tggtatggct     4320

tcattcagct ccggttccca acgatcaagg cgagttacat gatcccccat gttgtgcaaa     4380

aaagcggtta gctccttcgg tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta     4440

tcactcatgg ttatggcagc actgcataat tctcttactg tcatgccatc cgtaagatgc     4500

ttttctgtga ctggtgagta ctcaaccaag tcattctgag aatagtgtat gcggcgaccg     4560

agttgctctt gcccggcgtc aacacgggat aataccgcgc cacatagcag aactttaaaa     4620

gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct caaggatctt accgctgttg     4680

agatccagtt cgatgtaacc cactcgtgca cccaactgat cttcagcatc ttttactttc     4740

accagcgttt ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg     4800

gcgacacgga aatgttgaat actcatactc ttcctttttc aatattattg aagcatttat     4860

cagggttatt gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata     4920

ggggttccgc gcacatttcc ccgaaaagtg ccacctgacg tctaagagac cattattatc     4980

atgacattaa cctataaaaa taggcgtatc acgaggccct ttcgtcttca agaattgtct     5040

agaggcgcgc cgtttaaacc ctcagctacc gatgtacggg ccagatatac gcgttgacat     5100

tgattattga ctagttatta atagtaatca attacggggt cattagttca tagcccatat     5160

atggagttcc gcgttacata acttacggta aatggcccgc ctggctgacc gcccaacgac     5220

ccccgcccat tgacgtcaat aatgacgtat gttcccatag taacgccaat agggactttc     5280

cattgacgtc aatgggtgga ctatttacgg taaactgccc acttggcagt acatcaagtg     5340

tatcatatgc caagtacgcc ccctattgac gtcaatgacg gtaaatggcc cgcctggcat     5400

tatgcccagt acatgacctt atgggacttt cctacttggc agtacatcta cgtattagtc     5460

atcgctatta ccatggtgat gcggttttgg cagtacatca atgggcgtgg atagcggttt     5520

gactcacggg gatttccaag tctccacccc attgacgtca atgggagttt gttttggcac     5580

caaaatcaac gggactttcc aaaatgtcgt aacaactccg ccccattgac gcaaatgggc     5640

ggtaggcgtg tacggtggga ggtctatata agcagagctc tctggctaac tagagaaccc     5700

actgcttact ggcttatcga aattaatacg actcactata gcaattgcac gtgtggccac     5760

aggtaagttt aaagctcagg tcgagaccgg gcctttgtcc ggcgctccct tggagcctac     5820

ctagactcag ccggctctcc acgctttgcc tgaccctgct tgctcaactc tacgtctttg     5880

tttcgttttc tgttcctttc tctccacagg cttaagctcg aggccgccac catggctgtg     5940

ctggggctgc tgttctgcct ggtgacattc ccaagctgtg tgctgtccca ggtgcagctg     6000

gtgcagtctg gcgctgaggt gaagaagcct ggcgcctccg tgaaggtctc ctgcaaggct     6060

tctggctaca cattcaccaa ctacgctatg aactgggtgc ggcaggcccc tggccagggg     6120

ctggagtgga tgggctggat caacacttac accggtgagc caacctacag cgacgacttc     6180

aagggcagag tcaccttcac cctggacaca tccaccagca cagcctacat ggagctgagg     6240

agcctgagat ctgacgacac cgccgtgtat tactgtgcca gaggtggagg ctacgatgag     6300

gactacttcg actactgggg ccagggcacc ctggtcaccg tctccagcgc tagcaccaag     6360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc     6420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc     6480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc     6540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac     6600

gtgaatcaca agcccagcaa caccaaggtg gacaagaaag ttgagcccaa atcttgtgac     6660

aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc     6720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc     6780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc     6840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt     6900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc     6960

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg     7020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     7080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     7140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     7200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     7260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     7320

tccctgtctc cgggtaaata aatcgatgat tctagatacg ggtccggagg atccagatcc     7380

ccctcgcttt cttgctgtcc aatttctatt aaaggttcct ttgttcccta agtccaacta     7440

ctaaactggg ggatattatg aagggccttg agcatctgga ttctgcctaa taaaaaacat     7500

ttattttcat tgcaatgatg tatttaaatt atttctgaat attttactaa aaagggaatg     7560

tgggaggtca gtgcatttaa aacataaaga aatgaagagg gggatctgtc gacaagctct     7620

agagagctca cgcgttgatc atgtacaggc cggccaagct ttcgactagc ttggcacgcc     7680

agaaatccgc gcggtggttt ttgggggtcg ggggtgtttg gcagccacag acgcccggtg     7740

ttcgtgtcgc gccagtacat gcggtccatg cccaggccat ccaaaaacca tgggtctgtc     7800

tgctcagtcc agtcgtggac ctgaccccac gcaacgccca aaataataac ccccacgaac     7860

cataaaccat tccccatggg ggaccccgtc cctaacccac ggggccagtg gctatggcag     7920

ggcctgccgc cccgacgttg gctgcgagcc ctgggccttc acccgaactt ggggggtggg     7980

gtggggaaaa ggaagaaacg cgggcgtatt ggccccaatg gggtctcggt ggggtatcga     8040

cagagtgcca gccctgggac cgaaccccgc gtttatgaac aaacgaccca acacccgtgc     8100

gttttattct gtctttttat tgccgtcata gcgcgggttc cttccggtat tgtctccttc     8160

cgtgtttcag ttagcctccc ccatctcccg atccggacga gtgctggggc gtcggtttcc     8220

actatcggcg agtacttcta cacagccatc ggtccagacg gccgcgcttc tgcgggcgat     8280

ttgtgtacgc ccgacagtcc cggctccgga tcggacgatt gcgtcgcatc gaccctgcgc     8340

ccaagctgca tcatcgaaat tgccgtcaac caagctctga tagagttggt caagaccaat     8400

gcggagcata tacgcccgga gccgcggcga tcctgcaagc tccggatgcc tccgctcgaa     8460

gtagcgcgtc tgctgctcca tacaagccaa ccacggcctc cagaagaaga tgttggcgac     8520

ctcgtattgg gaatccccga acatcgcctc gctccagtca atgaccgctg ttatgcggcc     8580

attgtccgtc aggacattgt tggagccgaa atccgcgtgc acgaggtgcc ggacttcggg     8640

gcagtcctcg gcccaaagca tcagctcatc gagagcctgc gcgacggacg cactgacggt     8700

gtcgtccatc acagtttgcc agtgatacac atggggatca gcaatcgcgc atatgaaatc     8760

acgccatgta gtgtattgac cgattccttg cggtccgaat gggccgaacc cgctcgtctg     8820

gctaagatcg gccgcagcga tcgcatccat ggcctccgcg accggctgca gaacagcggg     8880

cagttcggtt tcaggcaggt cttgcaacgt gacaccctgt gcacggcggg agatgcaata     8940

ggtcaggctc tcgctgaatt ccccaatgtc aagcacttcc ggaatcggga gcgcggccga     9000

tgcaaagtgc cgataaacat aacgatcttt gtagaaacca tcggcgcagc tatttacccg     9060

caggacatat ccacgccctc ctacatcgaa gctgaaagca cgagattctt cgccctccga     9120

gagctgcatc aggtcggaga cgctgtcgaa cttttcgatc agaaacttct cgacagacgt     9180

cgcggtgagt tcaggctttt tcatatctca ttgccccccg ggatctgcgg cacgctgttg     9240

acgctgttaa gcgggtcgct gcagggtcgc tcggtgttcg aggccacacg cgtcacctta     9300

atatgcgaag tggacctcgg accgcgccgc cccgactgca tctgcgtgtt cgaattcgcc     9360

aatgacaaga cgctgggcgg ggtttgtgtc atcatagaac taaagacatg caaatatatt     9420

tcttccgggg acaccgccag caaacgcgag caacgggcca cggggatgaa gcagggcggc     9480

acctcgctaa cggattcacc actccaagaa ttggagccaa tcaattcttg cggagaactg     9540

tgaatgcgca aaccaaccct tggcagaaca tatccatcgc gtccgccatc tccagcagcc     9600

gcacgcggcg catctcgggg ccgacgcgct gggctacgtc ttgctggcgt tcgcacaggc     9660

cggccagcgc gcggccggcc ggtaccacgc gttggccaca tatggcggcc gctcgcgatt     9720

aattaatcgc gatggccaca tatggagctc tctagagctt gtcgacagat ccccctcttc     9780

atttctttat gttttaaatg cactgacctc ccacattccc tttttagtaa aatattcaga     9840

aataatttaa atacatcatt gcaatgaaaa taaatgtttt ttattaggca gaatccagat     9900

gctcaaggcc cttcataata tcccccagtt tagtagttgg acttagggaa caaaggaacc     9960

tttaatagaa attggacagc aagaaagcga gggggatctg gatcctttaa cactctcccc    10020

tgttgaagct ctttgtgacg ggcgagctca ggccctgatg ggtgacttcg caggcgtaga    10080

ctttgtgttt ctcgtagtct gctttgctca gcgtcagggt gctgctgagg ctgtaggtgc    10140

tgtccttgct gtcctgctct gtgacactct cctgggagtt acccgattgg agggcgttat    10200

ccaccttcca ctgtactttg gcctctctgg gatagaagtt attcagcagg cacacaacag    10260

aggcagttcc agatttcaac tgctcatcag atggcgggaa gatgaagaca gatggtgcag    10320

ccaccgtacg tttgatttcc accttggtcc cctgtccaaa ggtccatggt gtgtcatagt    10380

gctgctgaca gtagtacacg cccacatctt cggcctccac ccggctgatc ttcagagtga    10440

aatctgtccc agatccgctg ccgctgaacc tgtctggcac cccgctctcg cgagtgctgg    10500

cgaaatagat cagcagctga gggctctgcc ctggtttctg cagataccag gccaggtagg    10560

tcttctggtt gatggtgttg aacaggctct ggctgctctt gcagctgatg ctggctggct    10620

ctccgggtgt cacaggcagg gacagtggag actgggtcat cacgatatca catctcatgg    10680

ctggcaggaa cagcaccagc agccccagca gctgcactgg agccatggtg gcggcctcga    10740

gaagcttaag tttaattctt aagcctgtgg agagaaagga acagaaaacg aaacaaagac    10800

gtagagttga gcaagcaggg tcaggcaaag cgtggagagc cggctgagtc taggtaggct    10860

ccaagggagc gccggacaaa ggcccggtct cgacctgagc tttaaactta cctgtggcca    10920

cacgtgcaat tgctatagtg agtcgtatta atttcgataa gccagtaagc agtgggttct    10980

ctagttagcc agagagctct gcttatatag acctcccacc gtacacgcct accgcccatt    11040

tgcgtcaatg gggcggagtt gttacgacat tttggaaagt cccgttgatt ttggtgccaa    11100

aacaaactcc cattgacgtc aatggggtgg agacttggaa atccccgtga gtcaaaccgc    11160

tatccacgcc cattgatgta ctgccaaaac cgcatcacca tggtaatagc gatgactaat    11220

acgtagatgt actgccaagt aggaaagtcc cataaggtca tgtactgggc ataatgccag    11280

gcgggccatt taccgtcatt gacgtcaata gggggcgtac ttggcatatg atacacttga    11340

tgtactgcca agtgggcagt ttaccgtaaa tagtccaccc attgacgtca atggaaagtc    11400

cctattggcg ttactatggg aacatacgtc attattgacg tcaatgggcg ggggtcgttg    11460

ggcggtcagc caggcgggcc atttaccgta agttatgtaa cgcggaactc catatatggg    11520

ctatgaacta atgaccccgt aattgattac tattaataac tagtcaataa tcaatgtcaa    11580

cgcgtatatc tggcccgtac atcggtaact agtcggaccg gcccgggcca ccggtgctcg    11640

aagcttggat cgatccagac atgataagat acattgatga gtttggacaa accacaacta    11700

gaatgcagtg aaaaaaatgc tttatttgtg aaatttgtga tgctattgct ttatttgtaa    11760

ccattataag ctgcaataaa caagttaaca acaacaattg cattcatttt atgtttcagg    11820

ttcaggggga ggtgtgggag gttttttaaa gcaagtaaaa cctctacaaa tgtggtatgg    11880

ctgattatga tctctagtca a                                              11901


<210>  46
<211>  11922
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAIL17AV1 plasmid sequence

<400>  46
gcactataca tcaaatattc cttattaacc cctttacaaa ttaaaaagct aaaggtacac       60

aatttttgag catagttatt aatagcagac actctatgcc tgtgtggagt aagaaaaaac      120

agtatgttat gattataact gttatgccta cttataaagg ttacagaata tttttccata      180

attttcttgt atagcagtgc agctttttcc tttgtggtgt aaatagcaaa gcaagcaaga      240

gttctattac taaacacagc atgactcaaa aaacttagca attctgaagg aaagtccttg      300

gggtcttcta cctttctctt cttttttgga ggagtagaat gttgagagtc agcagtagcc      360

tcatcatcac tagatggcat ttcttctgag caaaacaggt tttcctcatt aaaggcattc      420

caccactgct cccattcatc agttccatag gttggaatct aaaatacaca aacaattaga      480

atcagtagtt taacacatta tacacttaaa aattttatat ttaccttaga gctttaaatc      540

tctgtaggta gtttgtccaa ttatgtcaca ccacagaagt aaggttcctt cacaaagatc      600

gatctaaagc cagcaaaagt cccatggtct tataaaaatg catagcttta ggaggggagc      660

agagaacttg aaagcatctt cctgttagtc tttcttctcg tagacttcaa acttatactt      720

gatgcctttt tcctcctgga cctcagagag gacgcctggg tattctggga gaagtttata      780

tttccccaaa tcaatttctg ggaaaaacgt gtcactttca aattcctgca tgatccttgt      840

cacaaagagt ctgaggtggc ctggttgatt catggcttcc tggtaaacag aactgcctcc      900

gactatccaa accatgtcta ctttacttgc caattccggt tgttcaataa gtcttaaggc      960

atcatccaaa cttttggcaa gaaaatgagc tcctcgtggt ggttctttga gttctctact     1020

gagaactata ttaattctgt cctttaaagg tcgattcttc tcaggaatgg agaaccaggt     1080

tttcctaccc ataatcacca gattctgttt accttccact gaagaggttg tggtcattct     1140

ttggaagtac ttgaactcgt tcctgagcgg aggccagggt aggtctccgt tcttgccaat     1200

ccccatattt tgggacacgg cgacgatgca gttcaatggt cgaaccatga tggcagcggg     1260

gataaaatcc taccagcctt cacgctagga ttgccgtcaa gtttggcgcg aaatcgcagc     1320

cctgagctgt cccccccccc aagctcagat ctgagcttgg tccctatggt gagtccgttc     1380

cgctcttgtg atgatagcca gacaagaaag agacaataca agacaaacac caaatagtag     1440

aaatagagac aagggtcact tatccgaggg tccctgttcg ggcgccagct gccgcagtcg     1500

gccgacctga gggtcgccgg ggtctgcggg gggaccctct ggaaagtgaa ggataagtga     1560

cgagcggaga cgggatggcg aacagacaca aacacacaag aggtgaatgt taggactgtt     1620

gcaagtttac tcaaaaaatc agcactcttt tatatcttgg tttacataag catttacata     1680

agatttggat aaattccaaa agaacatagg aaaatagaac actcagagct cagatcagaa     1740

cctttgatac caaaccaagt caggaaacca cttgtctcac atcctcgttt taagaacagt     1800

ttgtaaccaa aaacttactt aagccctggg aaccgcaagg ttgggccaat aaaggctatt     1860

cataataact catgccatga gtttttgcag aataatgttc tattagtcca gccactgtcc     1920

cctccttggt atggaaaatc tttccccaaa agtgcattcc tgttcctaga taaatataat     1980

catgtacctg ttgtttcatg tcgtcttttt cttcttgaga caacatacac caaggaggtc     2040

tagctctggc gagtctttca cgaaaaggga gggatctata taacacttta tagccattga     2100

ctgtaaccca cctatcccaa tttaagtcat atcttcctgt atatggtaag ggggcatctg     2160

ttggtctgta gatgtaaggt cccctataag tccctggttg ccaccacctg tctcctattt     2220

tgacaaaaac actctttttt ccctttttta cttctaggcc tgtggtcaat agtccttgca     2280

cctgttcttc aattgaggtt gagcgtctct ttctattttc tattcccatt tctaacttct     2340

gaatttgagt aaaaatagta ctaaaagata atgattcatt tcttaacata gtaactaata     2400

atctacctat tggattggtc ttattggtaa aaatataatt tttagcaagc attcttattt     2460

ctatttctga aggacaaaat cgatgcggct tgtaagagga agttggctgt ggtccttgcc     2520

tcaggaggaa ggtcgagttc tccgaattgt ttagattgta atcttgcaca gaagagctat     2580

taaaagagtc aagggtgaga gccctgcgag cacgaaccgc aacttccccc aatagcccca     2640

ggcaaagcag agctatgcca agtttgcagc agagaatgaa tatgtctttg tctgatgggc     2700

tcatccgttt gtgcgcagac gggtcgtcct tggtgggaaa caaccccttg gctgcttctc     2760

ccctaggtgt aggacactct cgggagttca accatttctg cccaagctca gatctgagct     2820

ttaatgcggt agtttatcac agttaaattg ctaacgcagt caggcaccgt gtatgaaatc     2880

taacaatgcg ctcatcgtca tcctcggcac cgtcaccctg gatgctgtag gcataggctt     2940

ggttatgccg gtactgccgg gcctcttgcg ggatatcgtc cattccgaca gcatcgccag     3000

tcactatggc gtgctgctag cgctcttccg cttcctcgct cactgactcg ctgcgctcgg     3060

tcgttcggct gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag     3120

aatcagggga taacgcagga aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc     3180

gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca     3240

aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt     3300

ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc     3360

tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc     3420

tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc     3480

ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact     3540

tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg     3600

ctacagagtt cttgaagtgg tggcctaact acggctacac tagaaggaca gtatttggta     3660

tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca     3720

aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa     3780

aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct cagtggaacg     3840

aaaactcacg ttaagggatt ttggtcatga gattatcaaa aaggatcttc acctagatcc     3900

ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa acttggtctg     3960

acagttacca atgcttaatc agtgaggcac ctatctcagc gatctgtcta tttcgttcat     4020

ccatagttgc ctgactcccc gtcgtgtaga taactacgat acgggagggc ttaccatctg     4080

gccccagtgc tgcaatgata ccgcgagacc cacgctcacc ggctccagat ttatcagcaa     4140

taaaccagcc agccggaagg gccgagcgca gaagtggtcc tgcaacttta tccgcctcca     4200

tccagtctat taattgttgc cgggaagcta gagtaagtag ttcgccagtt aatagtttgc     4260

gcaacgttgt tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt     4320

cattcagctc cggttcccaa cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa     4380

aagcggttag ctccttcggt cctccgatcg ttgtcagaag taagttggcc gcagtgttat     4440

cactcatggt tatggcagca ctgcataatt ctcttactgt catgccatcc gtaagatgct     4500

tttctgtgac tggtgagtac tcaaccaagt cattctgaga atagtgtatg cggcgaccga     4560

gttgctcttg cccggcgtca acacgggata ataccgcgcc acatagcaga actttaaaag     4620

tgctcatcat tggaaaacgt tcttcggggc gaaaactctc aaggatctta ccgctgttga     4680

gatccagttc gatgtaaccc actcgtgcac ccaactgatc ttcagcatct tttactttca     4740

ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg     4800

cgacacggaa atgttgaata ctcatactct tcctttttca atattattga agcatttatc     4860

agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat aaacaaatag     4920

gggttccgcg cacatttccc cgaaaagtgc cacctgacgt ctaagagacc attattatca     4980

tgacattaac ctataaaaat aggcgtatca cgaggccctt tcgtcttcaa gaattgtcta     5040

gaggcgcgcc gtttaaaccc tcagctaccg atgtacgggc cagatatacg cgttgacatt     5100

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata     5160

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc     5220

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc     5280

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt     5340

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt     5400

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca     5460

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg     5520

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc     5580

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg     5640

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca     5700

ctgcttactg gcttatcgaa attaatacga ctcactatag caattgcacg tgtggccaca     5760

ggtaagttta aagctcaggt cgagaccggg cctttgtccg gcgctccctt ggagcctacc     5820

tagactcagc cggctctcca cgctttgcct gaccctgctt gctcaactct acgtctttgt     5880

ttcgttttct gttcctttct ctccacaggc ttaagagtac tgccgccacc atggctgtgc     5940

tggggctgct gttctgcctg gtgacattcc caagctgtgt gctgtcccag gtgcagctgc     6000

aggagtctgg accaggcctg gtgaagccta gcgagaccct gagcctgacc tgtaccgtgt     6060

ctggattcag cctgcccagc cacagcgtga gctggatcag acagcctcca ggcaagggac     6120

tggagtggat cggcatcatt tggaatcaag gcggcactga ctataacagc gccttcaaga     6180

gccgcgtgac catctccgtg gacacctcca agaaccagtt cagcctgaag ctgagcagcg     6240

tgaccgctgc cgacaccgct gtgtattact gtgccagaaa tgcatacatc accgactact     6300

attacgagaa ctacttcatg gatgcctggg gacagggcac cctggtgacc gtgagctccg     6360

ctagcaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc acctctgggg     6420

gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg acggtgtcgt     6480

ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta cagtcctcag     6540

gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc acccagacct     6600

acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa gttgagccca     6660

aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaactc ctggggggac     6720

cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc cggacccctg     6780

aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt     6840

acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag cagtacaaca     6900

gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg aatggcaagg     6960

agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa accatctcca     7020

aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc cgggatgagc     7080

tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc agcgacatcg     7140

ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg cctcccgtgc     7200

tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag agcaggtggc     7260

agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac cactacacgc     7320

agaagagcct ctccctgtct ccgggtaaat gaatcgatga ttctagatac gggtccggag     7380

gatccagatc cccctcgctt tcttgctgtc caatttctat taaaggttcc tttgttccct     7440

aagtccaact actaaactgg gggatattat gaagggcctt gagcatctgg attctgccta     7500

ataaaaaaca tttattttca ttgcaatgat gtatttaaat tatttctgaa tattttacta     7560

aaaagggaat gtgggaggtc agtgcattta aaacataaag aaatgaagag ggggatctgt     7620

cgacaagctc tagagagctc acgcgttgat catgtacagg ccggccaagc tttcgactag     7680

cttggcacgc cagaaatccg cgcggtggtt tttgggggtc gggggtgttt ggcagccaca     7740

gacgcccggt gttcgtgtcg cgccagtaca tgcggtccat gcccaggcca tccaaaaacc     7800

atgggtctgt ctgctcagtc cagtcgtgga cctgacccca cgcaacgccc aaaataataa     7860

cccccacgaa ccataaacca ttccccatgg gggaccccgt ccctaaccca cggggccagt     7920

ggctatggca gggcctgccg ccccgacgtt ggctgcgagc cctgggcctt cacccgaact     7980

tggggggtgg ggtggggaaa aggaagaaac gcgggcgtat tggccccaat ggggtctcgg     8040

tggggtatcg acagagtgcc agccctggga ccgaaccccg cgtttatgaa caaacgaccc     8100

aacacccgtg cgttttattc tgtcttttta ttgccgtcat agcgcgggtt ccttccggta     8160

ttgtctcctt ccgtgtttca gttagcctcc cccatctccc gatccggacg agtgctgggg     8220

cgtcggtttc cactatcggc gagtacttct acacagccat cggtccagac ggccgcgctt     8280

ctgcgggcga tttgtgtacg cccgacagtc ccggctccgg atcggacgat tgcgtcgcat     8340

cgaccctgcg cccaagctgc atcatcgaaa ttgccgtcaa ccaagctctg atagagttgg     8400

tcaagaccaa tgcggagcat atacgcccgg agccgcggcg atcctgcaag ctccggatgc     8460

ctccgctcga agtagcgcgt ctgctgctcc atacaagcca accacggcct ccagaagaag     8520

atgttggcga cctcgtattg ggaatccccg aacatcgcct cgctccagtc aatgaccgct     8580

gttatgcggc cattgtccgt caggacattg ttggagccga aatccgcgtg cacgaggtgc     8640

cggacttcgg ggcagtcctc ggcccaaagc atcagctcat cgagagcctg cgcgacggac     8700

gcactgacgg tgtcgtccat cacagtttgc cagtgataca catggggatc agcaatcgcg     8760

catatgaaat cacgccatgt agtgtattga ccgattcctt gcggtccgaa tgggccgaac     8820

ccgctcgtct ggctaagatc ggccgcagcg atcgcatcca tggcctccgc gaccggctgc     8880

agaacagcgg gcagttcggt ttcaggcagg tcttgcaacg tgacaccctg tgcacggcgg     8940

gagatgcaat aggtcaggct ctcgctgaat tccccaatgt caagcacttc cggaatcggg     9000

agcgcggccg atgcaaagtg ccgataaaca taacgatctt tgtagaaacc atcggcgcag     9060

ctatttaccc gcaggacata tccacgccct cctacatcga agctgaaagc acgagattct     9120

tcgccctccg agagctgcat caggtcggag acgctgtcga acttttcgat cagaaacttc     9180

tcgacagacg tcgcggtgag ttcaggcttt ttcatatctc attgcccccc gggatctgcg     9240

gcacgctgtt gacgctgtta agcgggtcgc tgcagggtcg ctcggtgttc gaggccacac     9300

gcgtcacctt aatatgcgaa gtggacctcg gaccgcgccg ccccgactgc atctgcgtgt     9360

tcgaattcgc caatgacaag acgctgggcg gggtttgtgt catcatagaa ctaaagacat     9420

gcaaatatat ttcttccggg gacaccgcca gcaaacgcga gcaacgggcc acggggatga     9480

agcagggcgg cacctcgcta acggattcac cactccaaga attggagcca atcaattctt     9540

gcggagaact gtgaatgcgc aaaccaaccc ttggcagaac atatccatcg cgtccgccat     9600

ctccagcagc cgcacgcggc gcatctcggg gccgacgcgc tgggctacgt cttgctggcg     9660

ttcgcacagg ccggccagcg cgcggccggc cggtaccacg cgttggccac atatggcggc     9720

cgctcgcgat taattaatcg cgatggccac atatggagct ctctagagct tgtcgacaga     9780

tccccctctt catttcttta tgttttaaat gcactgacct cccacattcc ctttttagta     9840

aaatattcag aaataattta aatacatcat tgcaatgaaa ataaatgttt tttattaggc     9900

agaatccaga tgctcaaggc ccttcataat atcccccagt ttagtagttg gacttaggga     9960

acaaaggaac ctttaataga aattggacag caagaaagcg agggggatct ggatcctccg    10020

gagggcccct tctccctcta acactctccc ctgttgaagc tctttgtgac gggcgagctc    10080

aggccctgat gggtgacttc gcaggcgtag actttgtgtt tctcgtagtc tgctttgctc    10140

agcgtcaggg tgctgctgag gctgtaggtg ctgtccttgc tgtcctgctc tgtgacactc    10200

tcctgggagt tacccgattg gagggcgtta tccaccttcc actgtacttt ggcctctctg    10260

ggatagaagt tattcagcag gcacacaaca gaggcagttc cagatttcaa ctgctcatca    10320

gatggcggga agatgaagac agatggtgca gccaccgtac gtttgatttc caccttggtc    10380

ccctgtccaa aggtgtaggg tgtgtaatag ctctgctgac agtagtacac gcccacatct    10440

tcggcctcca cccggctgat cttcagagtg aaatctgtcc cagatccgct gccgctgaac    10500

ctgtctggca ccccgctctg ccgggtgctg gtccaataga tcagcagctg agggctctgc    10560

cctggtttct gcagatacca ggccaggtag ttcttctggt tctcgctgaa cagcaggctc    10620

tggctgctct tgcagctgat gctggctggc tctccgggtg tcacaggcag ggacagtgga    10680

gactgggtca tcacgatatc acatctcatg gctggcagga acagcaccag cagccccagc    10740

agctgcactg gagccatggt ggcggcgcta gcgaattctt aagcctgtgg agagaaagga    10800

acagaaaacg aaacaaagac gtagagttga gcaagcaggg tcaggcaaag cgtggagagc    10860

cggctgagtc taggtaggct ccaagggagc gccggacaaa ggcccggtct cgacctgagc    10920

tttaaactta cctgtggcca cacgtgcaat tgctatagtg agtcgtatta atttcgataa    10980

gccagtaagc agtgggttct ctagttagcc agagagctct gcttatatag acctcccacc    11040

gtacacgcct accgcccatt tgcgtcaatg gggcggagtt gttacgacat tttggaaagt    11100

cccgttgatt ttggtgccaa aacaaactcc cattgacgtc aatggggtgg agacttggaa    11160

atccccgtga gtcaaaccgc tatccacgcc cattgatgta ctgccaaaac cgcatcacca    11220

tggtaatagc gatgactaat acgtagatgt actgccaagt aggaaagtcc cataaggtca    11280

tgtactgggc ataatgccag gcgggccatt taccgtcatt gacgtcaata gggggcgtac    11340

ttggcatatg atacacttga tgtactgcca agtgggcagt ttaccgtaaa tagtccaccc    11400

attgacgtca atggaaagtc cctattggcg ttactatggg aacatacgtc attattgacg    11460

tcaatgggcg ggggtcgttg ggcggtcagc caggcgggcc atttaccgta agttatgtaa    11520

cgcggaactc catatatggg ctatgaacta atgaccccgt aattgattac tattaataac    11580

tagtcaataa tcaatgtcaa cgcgtatatc tggcccgtac atcggtaact agtcggaccg    11640

gcccgggcca ccggtgctcg aagcttggat cgatccagac atgataagat acattgatga    11700

gtttggacaa accacaacta gaatgcagtg aaaaaaatgc tttatttgtg aaatttgtga    11760

tgctattgct ttatttgtaa ccattataag ctgcaataaa caagttaaca acaacaattg    11820

cattcatttt atgtttcagg ttcaggggga ggtgtgggag gttttttaaa gcaagtaaaa    11880

cctctacaaa tgtggtatgg ctgattatga tctctagtca ag                       11922


<210>  47
<211>  11859
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAPD16V1-GA plasmid sequence

<400>  47
gcactataca tcaaatattc cttattaacc cctttacaaa ttaaaaagct aaaggtacac       60

aatttttgag catagttatt aatagcagac actctatgcc tgtgtggagt aagaaaaaac      120

agtatgttat gattataact gttatgccta cttataaagg ttacagaata tttttccata      180

attttcttgt atagcagtgc agctttttcc tttgtggtgt aaatagcaaa gcaagcaaga      240

gttctattac taaacacagc atgactcaaa aaacttagca attctgaagg aaagtccttg      300

gggtcttcta cctttctctt cttttttgga ggagtagaat gttgagagtc agcagtagcc      360

tcatcatcac tagatggcat ttcttctgag caaaacaggt tttcctcatt aaaggcattc      420

caccactgct cccattcatc agttccatag gttggaatct aaaatacaca aacaattaga      480

atcagtagtt taacacatta tacacttaaa aattttatat ttaccttaga gctttaaatc      540

tctgtaggta gtttgtccaa ttatgtcaca ccacagaagt aaggttcctt cacaaagatc      600

gatctaaagc cagcaaaagt cccatggtct tataaaaatg catagcttta ggaggggagc      660

agagaacttg aaagcatctt cctgttagtc tttcttctcg tagacttcaa acttatactt      720

gatgcctttt tcctcctgga cctcagagag gacgcctggg tattctggga gaagtttata      780

tttccccaaa tcaatttctg ggaaaaacgt gtcactttca aattcctgca tgatccttgt      840

cacaaagagt ctgaggtggc ctggttgatt catggcttcc tggtaaacag aactgcctcc      900

gactatccaa accatgtcta ctttacttgc caattccggt tgttcaataa gtcttaaggc      960

atcatccaaa cttttggcaa gaaaatgagc tcctcgtggt ggttctttga gttctctact     1020

gagaactata ttaattctgt cctttaaagg tcgattcttc tcaggaatgg agaaccaggt     1080

tttcctaccc ataatcacca gattctgttt accttccact gaagaggttg tggtcattct     1140

ttggaagtac ttgaactcgt tcctgagcgg aggccagggt aggtctccgt tcttgccaat     1200

ccccatattt tgggacacgg cgacgatgca gttcaatggt cgaaccatga tggcagcggg     1260

gataaaatcc taccagcctt cacgctagga ttgccgtcaa gtttggcgcg aaatcgcagc     1320

cctgagctgt cccccccccc aagctcagat ctgagcttgg tccctatggt gagtccgttc     1380

cgctcttgtg atgatagcca gacaagaaag agacaataca agacaaacac caaatagtag     1440

aaatagagac aagggtcact tatccgaggg tccctgttcg ggcgccagct gccgcagtcg     1500

gccgacctga gggtcgccgg ggtctgcggg gggaccctct ggaaagtgaa ggataagtga     1560

cgagcggaga cgggatggcg aacagacaca aacacacaag aggtgaatgt taggactgtt     1620

gcaagtttac tcaaaaaatc agcactcttt tatatcttgg tttacataag catttacata     1680

agatttggat aaattccaaa agaacatagg aaaatagaac actcagagct cagatcagaa     1740

cctttgatac caaaccaagt caggaaacca cttgtctcac atcctcgttt taagaacagt     1800

ttgtaaccaa aaacttactt aagccctggg aaccgcaagg ttgggccaat aaaggctatt     1860

cataataact catgccatga gtttttgcag aataatgttc tattagtcca gccactgtcc     1920

cctccttggt atggaaaatc tttccccaaa agtgcattcc tgttcctaga taaatataat     1980

catgtacctg ttgtttcatg tcgtcttttt cttcttgaga caacatacac caaggaggtc     2040

tagctctggc gagtctttca cgaaaaggga gggatctata taacacttta tagccattga     2100

ctgtaaccca cctatcccaa tttaagtcat atcttcctgt atatggtaag ggggcatctg     2160

ttggtctgta gatgtaaggt cccctataag tccctggttg ccaccacctg tctcctattt     2220

tgacaaaaac actctttttt ccctttttta cttctaggcc tgtggtcaat agtccttgca     2280

cctgttcttc aattgaggtt gagcgtctct ttctattttc tattcccatt tctaacttct     2340

gaatttgagt aaaaatagta ctaaaagata atgattcatt tcttaacata gtaactaata     2400

atctacctat tggattggtc ttattggtaa aaatataatt tttagcaagc attcttattt     2460

ctatttctga aggacaaaat cgatgcggct tgtaagagga agttggctgt ggtccttgcc     2520

tcaggaggaa ggtcgagttc tccgaattgt ttagattgta atcttgcaca gaagagctat     2580

taaaagagtc aagggtgaga gccctgcgag cacgaaccgc aacttccccc aatagcccca     2640

ggcaaagcag agctatgcca agtttgcagc agagaatgaa tatgtctttg tctgatgggc     2700

tcatccgttt gtgcgcagac gggtcgtcct tggtgggaaa caaccccttg gctgcttctc     2760

ccctaggtgt aggacactct cgggagttca accatttctg cccaagctca gatctgagct     2820

ttaatgcggt agtttatcac agttaaattg ctaacgcagt caggcaccgt gtatgaaatc     2880

taacaatgcg ctcatcgtca tcctcggcac cgtcaccctg gatgctgtag gcataggctt     2940

ggttatgccg gtactgccgg gcctcttgcg ggatatcgtc cattccgaca gcatcgccag     3000

tcactatggc gtgctgctag cgctcttccg cttcctcgct cactgactcg ctgcgctcgg     3060

tcgttcggct gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag     3120

aatcagggga taacgcagga aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc     3180

gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca     3240

aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt     3300

ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc     3360

tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc     3420

tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc     3480

ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact     3540

tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg     3600

ctacagagtt cttgaagtgg tggcctaact acggctacac tagaaggaca gtatttggta     3660

tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca     3720

aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa     3780

aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct cagtggaacg     3840

aaaactcacg ttaagggatt ttggtcatga gattatcaaa aaggatcttc acctagatcc     3900

ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa acttggtctg     3960

acagttacca atgcttaatc agtgaggcac ctatctcagc gatctgtcta tttcgttcat     4020

ccatagttgc ctgactcccc gtcgtgtaga taactacgat acgggagggc ttaccatctg     4080

gccccagtgc tgcaatgata ccgcgagacc cacgctcacc ggctccagat ttatcagcaa     4140

taaaccagcc agccggaagg gccgagcgca gaagtggtcc tgcaacttta tccgcctcca     4200

tccagtctat taattgttgc cgggaagcta gagtaagtag ttcgccagtt aatagtttgc     4260

gcaacgttgt tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt     4320

cattcagctc cggttcccaa cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa     4380

aagcggttag ctccttcggt cctccgatcg ttgtcagaag taagttggcc gcagtgttat     4440

cactcatggt tatggcagca ctgcataatt ctcttactgt catgccatcc gtaagatgct     4500

tttctgtgac tggtgagtac tcaaccaagt cattctgaga atagtgtatg cggcgaccga     4560

gttgctcttg cccggcgtca acacgggata ataccgcgcc acatagcaga actttaaaag     4620

tgctcatcat tggaaaacgt tcttcggggc gaaaactctc aaggatctta ccgctgttga     4680

gatccagttc gatgtaaccc actcgtgcac ccaactgatc ttcagcatct tttactttca     4740

ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg     4800

cgacacggaa atgttgaata ctcatactct tcctttttca atattattga agcatttatc     4860

agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat aaacaaatag     4920

gggttccgcg cacatttccc cgaaaagtgc cacctgacgt ctaagagacc attattatca     4980

tgacattaac ctataaaaat aggcgtatca cgaggccctt tcgtcttcaa gaattgtcta     5040

gaggcgcgcc gtttaaaccc tcagctaccg atgtacgggc cagatatacg cgttgacatt     5100

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata     5160

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc     5220

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc     5280

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt     5340

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt     5400

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca     5460

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg     5520

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc     5580

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg     5640

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca     5700

ctgcttactg gcttatcgaa attaatacga ctcactatag caattgcacg tgtggccaca     5760

ggtaagttta aagctcaggt cgagaccggg cctttgtccg gcgctccctt ggagcctacc     5820

tagactcagc cggctctcca cgctttgcct gaccctgctt gctcaactct acgtctttgt     5880

ttcgttttct gttcctttct ctccacaggc ttaagctcga ggccgccacc atggccgtgc     5940

tgggcctgct gttctgcctg gtgaccttcc cttcctgcgt gctgtcccag gtgcagctgg     6000

tgcagtccgg cgtggaggtg aagaagcctg gcgcctccgt caaggtgtcc tgtaaggcct     6060

ccggctacac cttcaccaac tactacatgt actgggtgcg gcaggcccca ggccagggac     6120

tggagtggat gggcggcatc aacccttcca acggcggcac caacttcaac gagaagttca     6180

agaaccgggt gaccctgacc accgactcct ccaccacaac cgcctacatg gaactgaagt     6240

ccctgcagtt cgacgacacc gccgtgtact actgcgccag gcgggactac cggttcgaca     6300

tgggcttcga ctactggggc cagggcacca ccgtgaccgt gtcctccgct agcaccaagg     6360

gcccttccgt gttccctctg gccccttgct cccggtccac ctccgagtcc accgccgctc     6420

tgggctgtct ggtgaaggac tacttccctg agcctgtgac cgtgagctgg aactctggcg     6480

ccctgacctc cggcgtgcac accttccctg ccgtgctgca gtcctccggc ctgtactccc     6540

tgtcctccgt ggtgaccgtg ccttcctcct ccctgggcac caagacctac acctgcaacg     6600

tggaccacaa gccttccaac accaaggtgg acaagcgggt ggagtccaag tacggccctc     6660

cttgccctcc ctgccctgcc cctgagttcc tgggcggacc ctccgtgttc ctgttccctc     6720

ctaagcctaa ggacaccctg atgatctccc ggacccctga ggtgacctgc gtggtggtgg     6780

acgtgtccca ggaagatcct gaggtccagt tcaattggta cgtggatggc gtggaggtgc     6840

acaacgccaa gaccaagcct cgggaggaac agttcaactc cacctaccgg gtggtgtctg     6900

tgctgaccgt gctgcaccag gactggctga acggcaagga atacaagtgc aaggtcagca     6960

acaagggcct gccctcctcc atcgagaaaa ccatctccaa ggccaagggc cagcctcgcg     7020

agcctcaggt gtacaccctg cctcctagcc aggaagagat gaccaagaat caggtgtccc     7080

tgacatgcct ggtgaagggc ttctaccctt ccgatatcgc cgtggagtgg gagagcaacg     7140

gccagccaga gaacaactac aagaccaccc ctcctgtgct ggactccgac ggctccttct     7200

tcctgtactc caggctgacc gtggacaagt cccggtggca ggaaggcaac gtcttttcct     7260

gctccgtgat gcacgaggcc ctgcacaacc actacaccca gaagtccctg tccctgtctc     7320

tgggcaagtg aatcgatgga tccagatccc cctcgctttc ttgctgtcca atttctatta     7380

aaggttcctt tgttccctaa gtccaactac taaactgggg gatattatga agggccttga     7440

gcatctggat tctgcctaat aaaaaacatt tattttcatt gcaatgatgt atttaaatta     7500

tttctgaata ttttactaaa aagggaatgt gggaggtcag tgcatttaaa acataaagaa     7560

atgaagaggg ggatctgtcg acaagctcta gagagctcac gcgttgatca tgtacaggcc     7620

ggccaagctt tcgactagct tggcacgcca gaaatccgcg cggtggtttt tgggggtcgg     7680

gggtgtttgg cagccacaga cgcccggtgt tcgtgtcgcg ccagtacatg cggtccatgc     7740

ccaggccatc caaaaaccat gggtctgtct gctcagtcca gtcgtggacc tgaccccacg     7800

caacgcccaa aataataacc cccacgaacc ataaaccatt ccccatgggg gaccccgtcc     7860

ctaacccacg gggccagtgg ctatggcagg gcctgccgcc ccgacgttgg ctgcgagccc     7920

tgggccttca cccgaacttg gggggtgggg tggggaaaag gaagaaacgc gggcgtattg     7980

gccccaatgg ggtctcggtg gggtatcgac agagtgccag ccctgggacc gaaccccgcg     8040

tttatgaaca aacgacccaa cacccgtgcg ttttattctg tctttttatt gccgtcatag     8100

cgcgggttcc ttccggtatt gtctccttcc gtgtttcagt tagcctcccc catctcccga     8160

tccggacgag tgctggggcg tcggtttcca ctatcggcga gtacttctac acagccatcg     8220

gtccagacgg ccgcgcttct gcgggcgatt tgtgtacgcc cgacagtccc ggctccggat     8280

cggacgattg cgtcgcatcg accctgcgcc caagctgcat catcgaaatt gccgtcaacc     8340

aagctctgat agagttggtc aagaccaatg cggagcatat acgcccggag ccgcggcgat     8400

cctgcaagct ccggatgcct ccgctcgaag tagcgcgtct gctgctccat acaagccaac     8460

cacggcctcc agaagaagat gttggcgacc tcgtattggg aatccccgaa catcgcctcg     8520

ctccagtcaa tgaccgctgt tatgcggcca ttgtccgtca ggacattgtt ggagccgaaa     8580

tccgcgtgca cgaggtgccg gacttcgggg cagtcctcgg cccaaagcat cagctcatcg     8640

agagcctgcg cgacggacgc actgacggtg tcgtccatca cagtttgcca gtgatacaca     8700

tggggatcag caatcgcgca tatgaaatca cgccatgtag tgtattgacc gattccttgc     8760

ggtccgaatg ggccgaaccc gctcgtctgg ctaagatcgg ccgcagcgat cgcatccatg     8820

gcctccgcga ccggctgcag aacagcgggc agttcggttt caggcaggtc ttgcaacgtg     8880

acaccctgtg cacggcggga gatgcaatag gtcaggctct cgctgaattc cccaatgtca     8940

agcacttccg gaatcgggag cgcggccgat gcaaagtgcc gataaacata acgatctttg     9000

tagaaaccat cggcgcagct atttacccgc aggacatatc cacgccctcc tacatcgaag     9060

ctgaaagcac gagattcttc gccctccgag agctgcatca ggtcggagac gctgtcgaac     9120

ttttcgatca gaaacttctc gacagacgtc gcggtgagtt caggcttttt catatctcat     9180

tgccccccgg gatctgcggc acgctgttga cgctgttaag cgggtcgctg cagggtcgct     9240

cggtgttcga ggccacacgc gtcaccttaa tatgcgaagt ggacctcgga ccgcgccgcc     9300

ccgactgcat ctgcgtgttc gaattcgcca atgacaagac gctgggcggg gtttgtgtca     9360

tcatagaact aaagacatgc aaatatattt cttccgggga caccgccagc aaacgcgagc     9420

aacgggccac ggggatgaag cagggcggca cctcgctaac ggattcacca ctccaagaat     9480

tggagccaat caattcttgc ggagaactgt gaatgcgcaa accaaccctt ggcagaacat     9540

atccatcgcg tccgccatct ccagcagccg cacgcggcgc atctcggggc cgacgcgctg     9600

ggctacgtct tgctggcgtt cgcacaggcc ggccagcgcg cggccggccg gtaccacgcg     9660

ttggccacat atggcggccg ctcgcgatta attaatcgcg atggccacat atggagctct     9720

ctagagcttg tcgacagatc cccctcttca tttctttatg ttttaaatgc actgacctcc     9780

cacattccct ttttagtaaa atattcagaa ataatttaaa tacatcattg caatgaaaat     9840

aaatgttttt tattaggcag aatccagatg ctcaaggccc ttcataatat cccccagttt     9900

agtagttgga cttagggaac aaaggaacct ttaatagaaa ttggacagca agaaagcgag     9960

ggggatctgg atccctccct tcagcactcg ccccggttga aggacttggt cacagggctg    10020

gacaggccct ggtgggtcac ctcgcaggcg tacaccttgt gcttctcgta gtcggccttg    10080

gacagggtca gggtggagga cagggagtag gtgctgtcct tggagtcctg ctcggtgacg    10140

gattcctggg agttgccgga ctgcagggca ttgtccacct tccactgcac cttggcctcc    10200

cgagggtaga agttgttcag caggcacacc acggaggcgg tgccggactt cagctgctcg    10260

tcggagggag ggaagatgaa cacggaagga gcggccaccg tacgcttgat ctccagcttg    10320

gtgccctggc cgaaggtcag aggcaggtcc cgggagtgct ggcagtagta cacgcccacg    10380

tcctcggcct ccacccggga gatcttcagg gtgaagtcgg tgccgctgcc ggagccggag    10440

aaccggtcag gcacgccgga ctccaggtag gaggccaggt agatcagcag ctggggggac    10500

tggccaggct tctgcagata ccagtgcagg taggagtagc cggaggtgga cacgcccttg    10560

gaggcccggc aggagatgga ggcaggctcg ccaggggtca caggcaggga cagaggggac    10620

tgggtcagca cgatctcgca ccgcatggca ggcaggaaca gcaccagcag gcccagcagc    10680

tgcacagggg ccatggtggc ggcctcgagg aattcttaag cctgtggaga gaaaggaaca    10740

gaaaacgaaa caaagacgta gagttgagca agcagggtca ggcaaagcgt ggagagccgg    10800

ctgagtctag gtaggctcca agggagcgcc ggacaaaggc ccggtctcga cctgagcttt    10860

aaacttacct gtggccacac gtgcaattgc tatagtgagt cgtattaatt tcgataagcc    10920

agtaagcagt gggttctcta gttagccaga gagctctgct tatatagacc tcccaccgta    10980

cacgcctacc gcccatttgc gtcaatgggg cggagttgtt acgacatttt ggaaagtccc    11040

gttgattttg gtgccaaaac aaactcccat tgacgtcaat ggggtggaga cttggaaatc    11100

cccgtgagtc aaaccgctat ccacgcccat tgatgtactg ccaaaaccgc atcaccatgg    11160

taatagcgat gactaatacg tagatgtact gccaagtagg aaagtcccat aaggtcatgt    11220

actgggcata atgccaggcg ggccatttac cgtcattgac gtcaataggg ggcgtacttg    11280

gcatatgata cacttgatgt actgccaagt gggcagttta ccgtaaatag tccacccatt    11340

gacgtcaatg gaaagtccct attggcgtta ctatgggaac atacgtcatt attgacgtca    11400

atgggcgggg gtcgttgggc ggtcagccag gcgggccatt taccgtaagt tatgtaacgc    11460

ggaactccat atatgggcta tgaactaatg accccgtaat tgattactat taataactag    11520

tcaataatca atgtcaacgc gtatatctgg cccgtacatc ggtaactagt cggaccggcc    11580

cgggccaccg gtgctcgaag cttggatcga tccagacatg ataagataca ttgatgagtt    11640

tggacaaacc acaactagaa tgcagtgaaa aaaatgcttt atttgtgaaa tttgtgatgc    11700

tattgcttta tttgtaacca ttataagctg caataaacaa gttaacaaca acaattgcat    11760

tcattttatg tttcaggttc agggggaggt gtgggaggtt ttttaaagca agtaaaacct    11820

ctacaaatgt ggtatggctg attatgatct ctagtcaag                           11859


<210>  48
<211>  11909
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pAHGFV1 plasmid sequence

<400>  48
ggcactatac atcaaatatt ccttattaac ccctttacaa attaaaaagc taaaggtaca       60

caatttttga gcatagttat taatagcaga cactctatgc ctgtgtggag taagaaaaaa      120

cagtatgtta tgattataac tgttatgcct acttataaag gttacagaat atttttccat      180

aattttcttg tatagcagtg cagctttttc ctttgtggtg taaatagcaa agcaagcaag      240

agttctatta ctaaacacag catgactcaa aaaacttagc aattctgaag gaaagtcctt      300

ggggtcttct acctttctct tcttttttgg aggagtagaa tgttgagagt cagcagtagc      360

ctcatcatca ctagatggca tttcttctga gcaaaacagg ttttcctcat taaaggcatt      420

ccaccactgc tcccattcat cagttccata ggttggaatc taaaatacac aaacaattag      480

aatcagtagt ttaacacatt atacacttaa aaattttata tttaccttag agctttaaat      540

ctctgtaggt agtttgtcca attatgtcac accacagaag taaggttcct tcacaaagat      600

cgatctaaag ccagcaaaag tcccatggtc ttataaaaat gcatagcttt aggaggggag      660

cagagaactt gaaagcatct tcctgttagt ctttcttctc gtagacttca aacttatact      720

tgatgccttt ttcctcctgg acctcagaga ggacgcctgg gtattctggg agaagtttat      780

atttccccaa atcaatttct gggaaaaacg tgtcactttc aaattcctgc atgatccttg      840

tcacaaagag tctgaggtgg cctggttgat tcatggcttc ctggtaaaca gaactgcctc      900

cgactatcca aaccatgtct actttacttg ccaattccgg ttgttcaata agtcttaagg      960

catcatccaa acttttggca agaaaatgag ctcctcgtgg tggttctttg agttctctac     1020

tgagaactat attaattctg tcctttaaag gtcgattctt ctcaggaatg gagaaccagg     1080

ttttcctacc cataatcacc agattctgtt taccttccac tgaagaggtt gtggtcattc     1140

tttggaagta cttgaactcg ttcctgagcg gaggccaggg taggtctccg ttcttgccaa     1200

tccccatatt ttgggacacg gcgacgatgc agttcaatgg tcgaaccatg atggcagcgg     1260

ggataaaatc ctaccagcct tcacgctagg attgccgtca agtttggcgc gaaatcgcag     1320

ccctgagctg tccccccccc caagctcaga tctgagcttg gtccctatgg tgagtccgtt     1380

ccgctcttgt gatgatagcc agacaagaaa gagacaatac aagacaaaca ccaaatagta     1440

gaaatagaga caagggtcac ttatccgagg gtccctgttc gggcgccagc tgccgcagtc     1500

ggccgacctg agggtcgccg gggtctgcgg ggggaccctc tggaaagtga aggataagtg     1560

acgagcggag acgggatggc gaacagacac aaacacacaa gaggtgaatg ttaggactgt     1620

tgcaagttta ctcaaaaaat cagcactctt ttatatcttg gtttacataa gcatttacat     1680

aagatttgga taaattccaa aagaacatag gaaaatagaa cactcagagc tcagatcaga     1740

acctttgata ccaaaccaag tcaggaaacc acttgtctca catcctcgtt ttaagaacag     1800

tttgtaacca aaaacttact taagccctgg gaaccgcaag gttgggccaa taaaggctat     1860

tcataataac tcatgccatg agtttttgca gaataatgtt ctattagtcc agccactgtc     1920

ccctccttgg tatggaaaat ctttccccaa aagtgcattc ctgttcctag ataaatataa     1980

tcatgtacct gttgtttcat gtcgtctttt tcttcttgag acaacataca ccaaggaggt     2040

ctagctctgg cgagtctttc acgaaaaggg agggatctat ataacacttt atagccattg     2100

actgtaaccc acctatccca atttaagtca tatcttcctg tatatggtaa gggggcatct     2160

gttggtctgt agatgtaagg tcccctataa gtccctggtt gccaccacct gtctcctatt     2220

ttgacaaaaa cactcttttt tccctttttt acttctaggc ctgtggtcaa tagtccttgc     2280

acctgttctt caattgaggt tgagcgtctc tttctatttt ctattcccat ttctaacttc     2340

tgaatttgag taaaaatagt actaaaagat aatgattcat ttcttaacat agtaactaat     2400

aatctaccta ttggattggt cttattggta aaaatataat ttttagcaag cattcttatt     2460

tctatttctg aaggacaaaa tcgatgcggc ttgtaagagg aagttggctg tggtccttgc     2520

ctcaggagga aggtcgagtt ctccgaattg tttagattgt aatcttgcac agaagagcta     2580

ttaaaagagt caagggtgag agccctgcga gcacgaaccg caacttcccc caatagcccc     2640

aggcaaagca gagctatgcc aagtttgcag cagagaatga atatgtcttt gtctgatggg     2700

ctcatccgtt tgtgcgcaga cgggtcgtcc ttggtgggaa acaacccctt ggctgcttct     2760

cccctaggtg taggacactc tcgggagttc aaccatttct gcccaagctc agatctgagc     2820

tttaatgcgg tagtttatca cagttaaatt gctaacgcag tcaggcaccg tgtatgaaat     2880

ctaacaatgc gctcatcgtc atcctcggca ccgtcaccct ggatgctgta ggcataggct     2940

tggttatgcc ggtactgccg ggcctcttgc gggatatcgt ccattccgac agcatcgcca     3000

gtcactatgg cgtgctgcta gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg     3060

gtcgttcggc tgcggcgagc ggtatcagct cactcaaagg cggtaatacg gttatccaca     3120

gaatcagggg ataacgcagg aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac     3180

cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc gcccccctga cgagcatcac     3240

aaaaatcgac gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg     3300

tttccccctg gaagctccct cgtgcgctct cctgttccga ccctgccgct taccggatac     3360

ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc atagctcacg ctgtaggtat     3420

ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag     3480

cccgaccgct gcgccttatc cggtaactat cgtcttgagt ccaacccggt aagacacgac     3540

ttatcgccac tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt     3600

gctacagagt tcttgaagtg gtggcctaac tacggctaca ctagaaggac agtatttggt     3660

atctgcgctc tgctgaagcc agttaccttc ggaaaaagag ttggtagctc ttgatccggc     3720

aaacaaacca ccgctggtag cggtggtttt tttgtttgca agcagcagat tacgcgcaga     3780

aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc tcagtggaac     3840

gaaaactcac gttaagggat tttggtcatg agattatcaa aaaggatctt cacctagatc     3900

cttttaaatt aaaaatgaag ttttaaatca atctaaagta tatatgagta aacttggtct     3960

gacagttacc aatgcttaat cagtgaggca cctatctcag cgatctgtct atttcgttca     4020

tccatagttg cctgactccc cgtcgtgtag ataactacga tacgggaggg cttaccatct     4080

ggccccagtg ctgcaatgat accgcgagac ccacgctcac cggctccaga tttatcagca     4140

ataaaccagc cagccggaag ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc     4200

atccagtcta ttaattgttg ccgggaagct agagtaagta gttcgccagt taatagtttg     4260

cgcaacgttg ttgccattgc tacaggcatc gtggtgtcac gctcgtcgtt tggtatggct     4320

tcattcagct ccggttccca acgatcaagg cgagttacat gatcccccat gttgtgcaaa     4380

aaagcggtta gctccttcgg tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta     4440

tcactcatgg ttatggcagc actgcataat tctcttactg tcatgccatc cgtaagatgc     4500

ttttctgtga ctggtgagta ctcaaccaag tcattctgag aatagtgtat gcggcgaccg     4560

agttgctctt gcccggcgtc aacacgggat aataccgcgc cacatagcag aactttaaaa     4620

gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct caaggatctt accgctgttg     4680

agatccagtt cgatgtaacc cactcgtgca cccaactgat cttcagcatc ttttactttc     4740

accagcgttt ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg     4800

gcgacacgga aatgttgaat actcatactc ttcctttttc aatattattg aagcatttat     4860

cagggttatt gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata     4920

ggggttccgc gcacatttcc ccgaaaagtg ccacctgacg tctaagagac cattattatc     4980

atgacattaa cctataaaaa taggcgtatc acgaggccct ttcgtcttca agaattgtct     5040

agaggcgcgc cgtttaaacc ctcagctacc gatgtacggg ccagatatac gcgttgacat     5100

tgattattga ctagttatta atagtaatca attacggggt cattagttca tagcccatat     5160

atggagttcc gcgttacata acttacggta aatggcccgc ctggctgacc gcccaacgac     5220

ccccgcccat tgacgtcaat aatgacgtat gttcccatag taacgccaat agggactttc     5280

cattgacgtc aatgggtgga ctatttacgg taaactgccc acttggcagt acatcaagtg     5340

tatcatatgc caagtacgcc ccctattgac gtcaatgacg gtaaatggcc cgcctggcat     5400

tatgcccagt acatgacctt atgggacttt cctacttggc agtacatcta cgtattagtc     5460

atcgctatta ccatggtgat gcggttttgg cagtacatca atgggcgtgg atagcggttt     5520

gactcacggg gatttccaag tctccacccc attgacgtca atgggagttt gttttggcac     5580

caaaatcaac gggactttcc aaaatgtcgt aacaactccg ccccattgac gcaaatgggc     5640

ggtaggcgtg tacggtggga ggtctatata agcagagctc tctggctaac tagagaaccc     5700

actgcttact ggcttatcga aattaatacg actcactata gcaattgcac gtgtggccac     5760

aggtaagttt aaagctcagg tcgagaccgg gcctttgtcc ggcgctccct tggagcctac     5820

ctagactcag ccggctctcc acgctttgcc tgaccctgct tgctcaactc tacgtctttg     5880

tttcgttttc tgttcctttc tctccacagg cttaaaacgc cgccaccatg gggtcaaccg     5940

ccatcctcgc cctcctcctg gctgttctcc aaggagtctg tgccgaagtg cagctggtgc     6000

agtctggagc agaggtgaaa aagcccgggg agtctctgaa gatctcctgt aagggttctg     6060

gatacagctt taccacctac tggatgcact gggtgcgcca gatgcccggg aaaggcctgg     6120

agtggatggg ggagattaat cctaccaacg gtcatactaa ctacaatccg tccttccaag     6180

gccaggtcac catctcagct gacaagtcca tcagcactgc ctacctgcag tggagcagcc     6240

tgaaggcctc ggacaccgcc atgtattact gtgcgagaaa ctatgttggt agcatctttg     6300

actactgggg ccaaggaacc ctggtcaccg tctcctcagc tagcaccaag ggcccatcgg     6360

tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc ctgggctgcc     6420

tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc gccctgacca     6480

gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc ctcagcagcg     6540

tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac gtgaatcaca     6600

agcccagcaa caccaaggtg gacaagaaag ttgagcccaa atcttgtgac aaaactcaca     6660

catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc ctcttccccc     6720

caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc gtggtggtgg     6780

acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc gtggaggtgc     6840

ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt gtggtcagcg     6900

tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc aaggtctcca     6960

acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg cagccccgag     7020

aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac caggtcagcc     7080

tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg gagagcaatg     7140

ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac ggctccttct     7200

tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac gtcttctcat     7260

gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc tccctgtctc     7320

cgggtaaatg aatcgatgat tctagatacg ggtccggagg atccagatcc ccctcgcttt     7380

cttgctgtcc aatttctatt aaaggttcct ttgttcccta agtccaacta ctaaactggg     7440

ggatattatg aagggccttg agcatctgga ttctgcctaa taaaaaacat ttattttcat     7500

tgcaatgatg tatttaaatt atttctgaat attttactaa aaagggaatg tgggaggtca     7560

gtgcatttaa aacataaaga aatgaagagg gggatctgtc gacaagctct agagagctca     7620

cgcgttgatc atgtacaggc cggccaagct ttcgactagc ttggcacgcc agaaatccgc     7680

gcggtggttt ttgggggtcg ggggtgtttg gcagccacag acgcccggtg ttcgtgtcgc     7740

gccagtacat gcggtccatg cccaggccat ccaaaaacca tgggtctgtc tgctcagtcc     7800

agtcgtggac ctgaccccac gcaacgccca aaataataac ccccacgaac cataaaccat     7860

tccccatggg ggaccccgtc cctaacccac ggggccagtg gctatggcag ggcctgccgc     7920

cccgacgttg gctgcgagcc ctgggccttc acccgaactt ggggggtggg gtggggaaaa     7980

ggaagaaacg cgggcgtatt ggccccaatg gggtctcggt ggggtatcga cagagtgcca     8040

gccctgggac cgaaccccgc gtttatgaac aaacgaccca acacccgtgc gttttattct     8100

gtctttttat tgccgtcata gcgcgggttc cttccggtat tgtctccttc cgtgtttcag     8160

ttagcctccc ccatctcccg atccggacga gtgctggggc gtcggtttcc actatcggcg     8220

agtacttcta cacagccatc ggtccagacg gccgcgcttc tgcgggcgat ttgtgtacgc     8280

ccgacagtcc cggctccgga tcggacgatt gcgtcgcatc gaccctgcgc ccaagctgca     8340

tcatcgaaat tgccgtcaac caagctctga tagagttggt caagaccaat gcggagcata     8400

tacgcccgga gccgcggcga tcctgcaagc tccggatgcc tccgctcgaa gtagcgcgtc     8460

tgctgctcca tacaagccaa ccacggcctc cagaagaaga tgttggcgac ctcgtattgg     8520

gaatccccga acatcgcctc gctccagtca atgaccgctg ttatgcggcc attgtccgtc     8580

aggacattgt tggagccgaa atccgcgtgc acgaggtgcc ggacttcggg gcagtcctcg     8640

gcccaaagca tcagctcatc gagagcctgc gcgacggacg cactgacggt gtcgtccatc     8700

acagtttgcc agtgatacac atggggatca gcaatcgcgc atatgaaatc acgccatgta     8760

gtgtattgac cgattccttg cggtccgaat gggccgaacc cgctcgtctg gctaagatcg     8820

gccgcagcga tcgcatccat ggcctccgcg accggctgca gaacagcggg cagttcggtt     8880

tcaggcaggt cttgcaacgt gacaccctgt gcacggcggg agatgcaata ggtcaggctc     8940

tcgctgaatt ccccaatgtc aagcacttcc ggaatcggga gcgcggccga tgcaaagtgc     9000

cgataaacat aacgatcttt gtagaaacca tcggcgcagc tatttacccg caggacatat     9060

ccacgccctc ctacatcgaa gctgaaagca cgagattctt cgccctccga gagctgcatc     9120

aggtcggaga cgctgtcgaa cttttcgatc agaaacttct cgacagacgt cgcggtgagt     9180

tcaggctttt tcatatctca ttgccccccg ggatctgcgg cacgctgttg acgctgttaa     9240

gcgggtcgct gcagggtcgc tcggtgttcg aggccacacg cgtcacctta atatgcgaag     9300

tggacctcgg accgcgccgc cccgactgca tctgcgtgtt cgaattcgcc aatgacaaga     9360

cgctgggcgg ggtttgtgtc atcatagaac taaagacatg caaatatatt tcttccgggg     9420

acaccgccag caaacgcgag caacgggcca cggggatgaa gcagggcggc acctcgctaa     9480

cggattcacc actccaagaa ttggagccaa tcaattcttg cggagaactg tgaatgcgca     9540

aaccaaccct tggcagaaca tatccatcgc gtccgccatc tccagcagcc gcacgcggcg     9600

catctcgggg ccgacgcgct gggctacgtc ttgctggcgt tcgcacaggc cggccagcgc     9660

gcggccggcc ggtaccacgc gttggccaca tatggcggcc gctcgcgatt aattaatcgc     9720

gatggccaca tatggagctc tctagagctt gtcgacagat ccccctcttc atttctttat     9780

gttttaaatg cactgacctc ccacattccc tttttagtaa aatattcaga aataatttaa     9840

atacatcatt gcaatgaaaa taaatgtttt ttattaggca gaatccagat gctcaaggcc     9900

cttcataata tcccccagtt tagtagttgg acttagggaa caaaggaacc tttaatagaa     9960

attggacagc aagaaagcga gggggatctg gatcctccta cgtatctaga atcatcgatt    10020

aacactctcc cctgttgaag ctctttgtca cggggctgct caggccctga tgggtcacct    10080

cgcaggcgta caccttgtgt ttctcgtagt ctgctttgct cagggtcagg gtgctgctca    10140

ggctgtaggt gctgtccttg ctgtcctgct ctgtcacgct ctcctgggag ttgccgctct    10200

ggagggcgtt atccaccttc cactgcacct tggcctctct gggatagaag ttattcagca    10260

ggcacaccac ggaggcagtt ccagacttca gctgctcatc agatggaggg aagatgaaca    10320

cagatggtgc agccaccgta cgtttgatct ccagcttggt cccctggcca aacgtgtacg    10380

gatagttgta actctgccca cagtagtaag ttgcaaaatc ttcaggttgc agactgctga    10440

tggtgagagt gaaatctgtc ccagatccac tgccactgaa ccttgatggg accccagtgt    10500

tccggttgga tgccccatag atcaggagct taggggcttt ccctggtttc tgctgatacc    10560

aggatacata agaaaccaca ttctcactgg ccttgcaagt gatggtgact ctgtctccta    10620

cagatgcaga cagggaggat ggagactggg tcatctggat gtcacatctg gcacctcgga    10680

gccagagtag caggagcccc aggagctgag cggggaccct catgtccatg gtggcggcga    10740

attctcgaga agcttaagtt taattcttaa gcctgtggag agaaaggaac agaaaacgaa    10800

acaaagacgt agagttgagc aagcagggtc aggcaaagcg tggagagccg gctgagtcta    10860

ggtaggctcc aagggagcgc cggacaaagg cccggtctcg acctgagctt taaacttacc    10920

tgtggccaca cgtgcaattg ctatagtgag tcgtattaat ttcgataagc cagtaagcag    10980

tgggttctct agttagccag agagctctgc ttatatagac ctcccaccgt acacgcctac    11040

cgcccatttg cgtcaatggg gcggagttgt tacgacattt tggaaagtcc cgttgatttt    11100

ggtgccaaaa caaactccca ttgacgtcaa tggggtggag acttggaaat ccccgtgagt    11160

caaaccgcta tccacgccca ttgatgtact gccaaaaccg catcaccatg gtaatagcga    11220

tgactaatac gtagatgtac tgccaagtag gaaagtccca taaggtcatg tactgggcat    11280

aatgccaggc gggccattta ccgtcattga cgtcaatagg gggcgtactt ggcatatgat    11340

acacttgatg tactgccaag tgggcagttt accgtaaata gtccacccat tgacgtcaat    11400

ggaaagtccc tattggcgtt actatgggaa catacgtcat tattgacgtc aatgggcggg    11460

ggtcgttggg cggtcagcca ggcgggccat ttaccgtaag ttatgtaacg cggaactcca    11520

tatatgggct atgaactaat gaccccgtaa ttgattacta ttaataacta gtcaataatc    11580

aatgtcaacg cgtatatctg gcccgtacat cggtaactag tcggaccggc ccgggccacc    11640

ggtgctcgaa gcttggatcg atccagacat gataagatac attgatgagt ttggacaaac    11700

cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg ctattgcttt    11760

atttgtaacc attataagct gcaataaaca agttaacaac aacaattgca ttcattttat    11820

gtttcaggtt cagggggagg tgtgggaggt tttttaaagc aagtaaaacc tctacaaatg    11880

tggtatggct gattatgatc tctagtcaa                                      11909




