                         SEQUENCE LISTING

<110>  Nordic Bioscience A/S
 
<120>  Assessment of subchondral bone remodelling

<130>  PJS/P16428WO

<150>  GB0820785.4
<151>  2008-11-13

<160>  85    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Hydroxyproline

<400>  1

Glu Gly Pro Pro Gly Pro Gln Gly 
1               5               


<210>  2
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Hydroxyproline

<400>  2

Gly Pro Pro Gly Pro Gln Gly 
1               5           


<210>  3
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  3

Gly Pro Pro Gly Pro Gln Gly 
1               5           


<210>  4
<211>  20
<212>  PRT
<213>  Bos taurus

<400>  4

Pro Gly Asp Asp Gly Glu Ala Gly Lys Pro Gly Lys Ser Gly Glu Arg 
1               5                   10                  15      


Gly Pro Pro Gly 
            20  


<210>  5
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  5

Pro Gly Asp Asp Gly Glu Ala Gly Lys Pro Gly Lys Ala Gly Glu Arg 
1               5                   10                  15      


Gly Pro Pro Gly 
            20  


<210>  6
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  6

Gly Glu Ala Gly Lys Pro Gly 
1               5           


<210>  7
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  7

Gly Pro Pro Gly Pro Gln Gly 
1               5           


<210>  8
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  8

Gly Glu Pro Gly Asp Asp Gly Pro Ser Gly 
1               5                   10  


<210>  9
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  9

Ala Pro Gly Glu Asp Gly Arg Pro Gly Pro Pro Gly Pro 
1               5                   10              


<210>  10
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  10

Gly Lys Val Gly Pro Ser Gly Ala Pro Gly Glu Asp Gly Arg Pro Gly 
1               5                   10                  15      


<210>  11
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  11

Ala Glu Gly Pro Pro Gly Pro Gln Gly 
1               5                   


<210>  12
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  12

Gly Pro Pro Gly Pro Gln Gly Leu Ala Gly 
1               5                   10  


<210>  13
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  13

Gly Glu Pro Gly Asp Asp Gly Pro Ser 
1               5                   


<210>  14
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  14

Gly Glu Pro Gly Asp Asp Gly Pro Ser Gly Ala Glu Gly Pro Pro Gly 
1               5                   10                  15      


<210>  15
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  15

Glu Lys Gly Glu Pro Gly Asp Asp Ala Pro Ser Gly Ala Glu Gly Pro 
1               5                   10                  15      


Pro Gly Pro Gln Gly 
            20      


<210>  16
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  16

Gly Pro Pro Gly Pro Pro Gly Lys Pro Gly Asp Asp Gly Glu Ala Gly 
1               5                   10                  15      


Lys Pro Gly Lys Ala 
            20      


<210>  17
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  17

Gly Pro Pro Gly Pro Arg Gly Arg Ser Gly Glu Thr Gly Pro Ala Gly 
1               5                   10                  15      


Pro Pro Gly Asn Pro 
            20      


<210>  18
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  18

Gly Ala Pro Gly Pro Gln Gly Phe Gln Gly Asn Pro Gly Glu Pro Gly 
1               5                   10                  15      


Glu Pro Gly Val Ser Tyr 
            20          


<210>  19
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  19

Gly Glu Pro Gly Asp Asp Ala Gly Pro Ser Gly Ala Glu Gly Pro Pro 
1               5                   10                  15      


Gly Pro Gln Gly 
            20  


<210>  20
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  20

His Arg Gly Tyr Pro Gly Leu Asp Gly 
1               5                   


<210>  21
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  21

Cys Gly Lys Val Gly Pro Ser Gly Ala Pro Gly Glu Asp Gly Arg Pro 
1               5                   10                  15      


Gly Pro Pro Gly Pro Gln Tyr 
            20              


<210>  22
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  22

Ala Pro Gly Glu Asp Gly Arg Pro Gly Pro Pro Gly Pro 
1               5                   10              


<210>  23
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  23

Gly Gln Pro Gly 
1               


<210>  24
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  24

Cys Gly Gly Glu Gly Pro Pro Gly Pro Gln Gly 
1               5                   10      


<210>  25
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  25

Gly Ala Glu Gly Pro Pro Gly Pro Gln Gly Leu Ala Gly Gln Arg Gly 
1               5                   10                  15      


Ile Val Gly 
            


<210>  26
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  26

Gly Ala Pro Gly Thr Pro Gly Pro Gln Gly Ile Ala Gly Gln Arg Gly 
1               5                   10                  15      


Val Val Gly 
            


<210>  27
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  27

Gly Pro Pro Gly Thr Pro Gly Pro Gln Gly Leu Leu Gly Ala Pro Gly 
1               5                   10                  15      


Ile Leu Gly 
            


<210>  28
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  28

Gly Pro Pro Gly Ala Pro Gly Pro Leu Gly Ile Ala Gly Ile Thr Gly 
1               5                   10                  15      


Ala Arg Gly 
            


<210>  29
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  29

Cys Gly Gly Glu Gly Pro Pro Gly Pro Gln Gly Leu 
1               5                   10          


<210>  30
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  30

Cys Gly Gly Glu Gly Pro Pro Gly Pro Gln Gly Leu Ala 
1               5                   10              


<210>  31
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  31

Cys Gly Gly Glu Gly Pro Pro Gly Pro Gln 
1               5                   10  


<210>  32
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  32

Cys Gly Gly Glu Gly Pro Pro Gly Pro 
1               5                   


<210>  33
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  33

Cys Gly Pro Pro Gly Pro Gln Gly 
1               5               


<210>  34
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  34

Leu Gln Gly Pro Ala Gly Pro Pro Gly Glu Lys Gly Glu Pro Gly Asp 
1               5                   10                  15      


Asp Gly Pro Ser Gly Ala Glu Gly Pro Pro Gly Pro Gln Gly 
            20                  25                  30  


<210>  35
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  35

Pro Gly Pro Gln Gly 
1               5   


<210>  36
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  36

Pro Pro Gly Pro Gln Gly 
1               5       


<210>  37
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  37

Val Leu Gln Gly Pro Ala Gly Pro Pro Gly Glu Lys Gly Glu Pro Gly 
1               5                   10                  15      


Asp Asp Gly Pro Ser Gly Ala Glu Gly Pro Pro Gly Pro Gln Gly 
            20                  25                  30      


<210>  38
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  38

Lys Gly Ala Arg Gly Asp Ser Gly Pro Pro Gly Arg Ala Gly Glu Pro 
1               5                   10                  15      


Gly Leu Gln Gly Pro Ala Gly Pro Pro Gly Glu Lys Gly Glu Pro Gly 
            20                  25                  30          


Asp Asp Gly Pro Ser Gly Ala Glu Gly Pro Pro Gly Pro Gln Gly 
        35                  40                  45          


<210>  39
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  39

Ala Arg Gly Asp Ser Gly Pro Pro Gly Arg Ala Gly Glu Pro Gly Leu 
1               5                   10                  15      


Gln Gly Pro Ala Gly Pro Pro Gly Glu Lys Gly Glu Pro Gly Asp Asp 
            20                  25                  30          


Gly Pro Ser Gly Ala Glu Gly Pro Pro Gly Pro Gln Gly 
        35                  40                  45  


<210>  40
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  40

Gly Pro Ala Gly Pro Pro Gly Glu Lys Gly Glu Pro Gly Asp Asp Gly 
1               5                   10                  15      


Pro Ser Gly Ala Glu Gly Pro Pro Gly Pro Gln Gly 
            20                  25              


<210>  41
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  41

Gly Pro Ile Gly Pro Pro Gly Glu Arg Gly Ala Pro Gly Asn Arg Gly 
1               5                   10                  15      


Phe Pro Gly Gln Asp Gly Leu Ala Gly Pro Lys Gly Ala Pro Gly Glu 
            20                  25                  30          


Arg Gly Pro Ser Gly Leu Ala Gly Pro Lys Gly Ala Asn Gly Asp Pro 
        35                  40                  45              


Gly Arg Pro Gly Glu Pro Gly Leu Pro Gly Ala Arg Gly Leu Thr Gly 
    50                  55                  60                  


Arg Pro Gly Asp Ala Gly Pro Gln Gly Lys Val Gly Pro Ser Gly Ala 
65                  70                  75                  80  


Pro Gly Glu Asp Gly Arg Pro Gly Pro Pro Gly Pro Gln Gly Ala Arg 
                85                  90                  95      


Gly Gln Pro Gly Val Met Gly Phe Pro Gly Pro Lys Gly Ala Asn Gly 
            100                 105                 110         


Glu Pro Gly Lys Ala Gly Glu Lys Gly Leu Pro Gly Ala Pro Gly Leu 
        115                 120                 125             


Gly Leu Pro Gly Lys Asp Gly Glu Thr Gly Ala Glu Gly Pro Pro Pro 
    130                 135                 140                 


Ala 
145 


<210>  42
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Pro Gly Glu Arg Gly Ala Ala Gly Ile Ala Gly Pro Lys Gly Asp 
1               5                   10                  15      


Arg Gly Asp Val Gly Glu Lys Gly Pro Glu Gly Ala Pro Gly Lys Asp 
            20                  25                  30          


Gly Gly Arg Gly Leu Thr Gly Pro Ile Gly Pro Pro Gly Pro Ala Gly 
        35                  40                  45              


Ala Asn Gly Glu Lys Gly Glu Val Gly Pro Pro Gly Pro Ala Gly Ser 
    50                  55                  60                  


Ala Gly Ala Arg Gly Ala Pro Gly Glu Arg Gly Glu Thr Gly Pro Pro 
65                  70                  75                  80  


Gly Thr Ser Gly Ile Ala Gly Pro Pro Gly Ala Asp Gly Gln Pro Gly 
                85                  90                  95      


Ala Lys Gly Glu Gln Gly Glu Ala Gly Gln Lys Gly Asp Ala Gly Ala 
            100                 105                 110         


Pro Gly Pro Gln Gly Pro Ser Gly Ala Pro Gly Pro Gln Gly Pro Thr 
        115                 120                 125             


Gly Val Thr Gly Pro Lys Gly Ala Arg Gly Ala Gln Gly Pro Pro Gly 
    130                 135                 140                 


Ala Thr Gly Phe Pro Gly Ala Ala Gly Arg Val Gly Pro Pro Gly Ser 
145                 150                 155                 160 


Asn Gly Asn Pro Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Lys Asp 
                165                 170                 175     


Gly Pro Lys Gly Ala Arg Gly Asp Ser Gly Pro Pro Gly Arg Ala Gly 
            180                 185                 190         


Glu Pro Gly Leu Gln Gly Pro Ala Gly Pro Pro Gly Glu Lys Gly Glu 
        195                 200                 205             


Pro Gly Asp Asp Gly Pro Ser Gly Ala Glu Gly Pro Pro Gly Pro Gln 
    210                 215                 220                 


Gly Leu Ala Gly Gln Arg Gly Ile Val Gly Leu Pro Gly Gln Arg Gly 
225                 230                 235                 240 


Glu Arg Gly Phe Pro Gly Leu Pro Gly Pro Ser Gly Glu Pro Gly Gln 
                245                 250                 255     


Gln Gly Ala Pro Gly Ala Ser Gly Asp Arg Gly Pro Pro Gly Pro Val 
            260                 265                 270         


Gly Pro Pro Gly Leu Thr Gly Pro Ala Gly Glu Pro Gly Arg Glu Gly 
        275                 280                 285             


Ser Pro Gly Ala Asp Gly Pro Pro Gly Arg Asp Gly Ala Ala Gly Val 
    290                 295                 300                 


Lys Gly Asp Arg Gly Glu Thr Gly Ala Val Gly Ala Pro Gly Ala Pro 
305                 310                 315                 320 


Gly Pro Pro Gly Ser Pro Gly Pro Ala Gly Pro Thr Gly Lys Gln Gly 
                325                 330                 335     


Asp Arg Gly Glu Ala Gly Ala Gln Gly Pro Met 
            340                 345         


<210>  43
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  43

Glu Lys Gly Pro Asp Pro 
1               5       


<210>  44
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  Isomerised peptide bond

<400>  44

Gly Asp Ile Lys Asp Ile Val 
1               5           


<210>  45
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  Isomerised peptide bond

<400>  45

Glu Lys Gly Pro Asp 
1               5   


<210>  46
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  46

Gly Asp Ile Lys Asp Ile Val 
1               5           


<210>  47
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  47

Glu Lys Gly Pro Asp Pro 
1               5       


<210>  48
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  48

Pro Gly Pro Lys Gly 
1               5   


<210>  49
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  49

Pro Gly Val Lys Gly Glu 
1               5       


<210>  50
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  50

Gly Gln Lys Gly Glu Pro 
1               5       


<210>  51
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Unknown amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(9)
<223>  Unspecified amino acids

<220>
<221>  MISC_FEATURE
<222>  (11)..(12)
<223>  Unspecified amino acids

<400>  51

Gly Phe Gln Gly Leu Xaa Gly Xaa Xaa Gly Xaa Xaa Gly 
1               5                   10              


<210>  52
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Unspecified amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(9)
<223>  Unspecified amino acids

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Unspecified amino acid

<400>  52

Gly Leu Gln Gly Leu Xaa Gly Xaa Xaa Gly Xaa Ser Gly 
1               5                   10              


<210>  53
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  53

Gly Gln Pro Gly Pro Ala 
1               5       


<210>  54
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  54

Glu Pro Gly Gly Val Gly 
1               5       


<210>  55
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  55

Asp Gln Gly Val Pro Gly 
1               5       


<210>  56
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  56

Pro Lys Gly Ala Arg Gly 
1               5       


<210>  57
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  57

Arg Glu Gly Ser Pro Gly 
1               5       


<210>  58
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  58

Ala Gln Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly Ala Ala Gly Arg 
1               5                   10                  15      


<210>  59
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  59

Ala Ser Gly Asp Arg Gly Pro Pro Gly Pro Val 
1               5                   10      


<210>  60
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  60

Ala Ser Gly Asp Arg Gly Pro Pro Gly Pro Val Gly Pro Pro Gly 
1               5                   10                  15  


<210>  61
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  61

Gly Ala Asn Gly Glu Lys Gly Glu Val Gly Pro Pro Gly Pro Ala 
1               5                   10                  15  


<210>  62
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  62

Gly Ala Pro Gly Glu Asp Gly Arg Pro Gly Pro Pro Gly Pro Gln 
1               5                   10                  15  


<210>  63
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  63

Gly Ala Arg Gly Ala Pro Gly Glu Arg Gly Glu Thr Gly Pro Pro Gly 
1               5                   10                  15      


Pro Ala 
        


<210>  64
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  64

Gly Asp Arg Gly Pro Pro Gly Pro Val 
1               5                   


<210>  65
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  65

Gly Glu Arg Gly Phe Pro Gly 
1               5           


<210>  66
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  66

Gly Glu Arg Gly Phe Pro Gly Glu Arg 
1               5                   


<210>  67
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  67

Gly Glu Ser Gly Ser Pro Gly Glu Asn Gly Ser Pro Gly Pro Met 
1               5                   10                  15  


<210>  68
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  68

Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Glu Gly Gly Lys Pro Gly 
1               5                   10                  15      


<210>  69
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  69

Gly Pro Ile Gly Pro Pro Gly Pro Ala 
1               5                   


<210>  70
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  70

Gly Pro Pro Gly Pro Pro Gly Lys Pro Gly Asp Asp Gly Glu Ala Gly 
1               5                   10                  15      


Lys Pro Gly 
            


<210>  71
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  71

Gly Pro Pro Gly Pro Val 
1               5       


<210>  72
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  72

Gly Pro Pro Gly Pro Val Gly Pro Ala 
1               5                   


<210>  73
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  73

Leu Pro Gly Pro Pro Gly Pro Pro Gly Glu Gly Gly Lys Pro Gly 
1               5                   10                  15  


<210>  74
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  74

Asn Pro Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Pro Gly 
1               5                   10                  


<210>  75
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  75

Pro Ile Gly Pro Pro 
1               5   


<210>  76
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  76

Arg Glu Gly Ser Pro Gly Ala Asp Gly Pro Pro Gly Arg Asp Gly Ala 
1               5                   10                  15      


Ala Gly Val Lys 
            20  


<210>  77
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  77

Ser Asn Gly Asn Pro Gly Pro Pro Gly Pro Pro Gly Pro Ser 
1               5                   10                  


<210>  78
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  78

Leu Thr Gly Pro Ala Gly Gly Gly Gly Cys 
1               5                   10  


<210>  79
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  79

Leu Thr Gly Pro Ala Gly Glu Pro Gly Lys 
1               5                   10  


<210>  80
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  80

Gly Leu Thr Gly Pro Ala Gly Glu Pro Gly Lys 
1               5                   10      


<210>  81
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  81

Lys Gly Ala Thr Gly Pro Leu Gly Pro Lys 
1               5                   10  


<210>  82
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  82

Glu Ala Gly Lys Pro Gly 
1               5       


<210>  83
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  83

Arg Glu Gly Ser Pro Gly Gly Ala Asp Ala Pro 
1               5                   10      


<210>  84
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  84

Gly Arg Glu Gly Ser Pro Gly Gly Ala Asp Ala Pro 
1               5                   10          


<210>  85
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  85

Lys Gly Ala Thr Gly Pro Leu Gly Pro Lys 
1               5                   10  


