                         SEQUENCE LISTING

<110>  Wayne State University
 
<120>  Vaccines Targeting Cellular Death Receptors

<130>  0788.00015

<150>  US 61/111,798
<151>  2008-11-06

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  384
<212>  DNA
<213>  Mus musculus

<400>  1
aacccagccc ataatcgtcc agctggccta cagcggccgg aggagagccc atcaagagga       60

ccctgtctag caggccagta cctgtcagaa gggaactgca agccttgcag agagggtatt      120

gactacacca gccattccaa ccattctctg gattcatgta ttctctgcac agtctgtaag      180

gaagataaag tcgtagaaac ccgatgcaac ataaccacaa atacggtgtg tcgatgcaaa      240

ccaggcacct ttgaagataa agactcccct gagatctgcc agtcatgctc taactgcact      300

gacggggaag aggaactgac ttcctgtacc cccagagaaa accggaagtg tgtctccaaa      360

acggcttggg catcttggca taag                                             384


<210>  2
<211>  128
<212>  PRT
<213>  Mus musculus

<400>  2

Asn Pro Ala His Asn Arg Pro Ala Gly Leu Gln Arg Pro Glu Glu Ser 
1               5                   10                  15      


Pro Ser Arg Gly Pro Cys Leu Ala Gly Gln Tyr Leu Ser Glu Gly Asn 
            20                  25                  30          


Cys Lys Pro Cys Arg Glu Gly Ile Asp Tyr Thr Ser His Ser Asn His 
        35                  40                  45              


Ser Leu Asp Ser Cys Ile Leu Cys Thr Val Cys Lys Glu Asp Lys Val 
    50                  55                  60                  


Val Glu Thr Arg Cys Asn Ile Thr Thr Asn Thr Val Cys Arg Cys Lys 
65                  70                  75                  80  


Pro Gly Thr Phe Glu Asp Lys Asp Ser Pro Glu Ile Cys Gln Ser Cys 
                85                  90                  95      


Ser Asn Cys Thr Asp Gly Glu Glu Glu Leu Thr Ser Cys Thr Pro Arg 
            100                 105                 110         


Glu Asn Arg Lys Cys Val Ser Lys Thr Ala Trp Ala Ser Trp His Lys 
        115                 120                 125             


<210>  3
<211>  63
<212>  DNA
<213>  Mus musculus

<400>  3
ctaggcctct ggataggact cctggttcca gtagtgctgc tgattggagc tctgcttgtc       60

tgg                                                                     63


<210>  4
<211>  21
<212>  PRT
<213>  Mus musculus

<400>  4

Leu Gly Leu Trp Ile Gly Leu Leu Val Pro Val Val Leu Leu Ile Gly 
1               5                   10                  15      


Ala Leu Leu Val Trp 
            20      


<210>  5
<211>  390
<212>  DNA
<213>  Homo sapiens

<400>  5
gctctgatca cccaacaaga cctagctccc cagcagagag cggccccaca acaaaagagg       60

tccagcccct cagagggatt gtgtccacct ggacaccata tctcagaaga cggtagagat      120

tgcatctcct gcaaatatgg acaggactat agcactcact ggaatgacct ccttttctgc      180

ttgcgctgca ccaggtgtga ttcaggtgaa gtggagctaa gtccctgcac cacgaccaga      240

aacacagtgt gtcagtgcga agaaggcacc ttccgggaag aagattctcc tgagatgtgc      300

cggaagtgcc gcacagggtg tcccagaggg atggtcaagg tcggtgattg tacaccctgg      360

agtgacatcg aatgtgtcca caaagaatca                                       390


<210>  6
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  6

Ala Leu Ile Thr Gln Gln Asp Leu Ala Pro Gln Gln Arg Ala Ala Pro 
1               5                   10                  15      


Gln Gln Lys Arg Ser Ser Pro Ser Glu Gly Leu Cys Pro Pro Gly His 
            20                  25                  30          


His Ile Ser Glu Asp Gly Arg Asp Cys Ile Ser Cys Lys Tyr Gly Gln 
        35                  40                  45              


Asp Tyr Ser Thr His Trp Asn Asp Leu Leu Phe Cys Leu Arg Cys Thr 
    50                  55                  60                  


Arg Cys Asp Ser Gly Glu Val Glu Leu Ser Pro Cys Thr Thr Thr Arg 
65                  70                  75                  80  


Asn Thr Val Cys Gln Cys Glu Glu Gly Thr Phe Arg Glu Glu Asp Ser 
                85                  90                  95      


Pro Glu Met Cys Arg Lys Cys Arg Thr Gly Cys Pro Arg Gly Met Val 
            100                 105                 110         


Lys Val Gly Asp Cys Thr Pro Trp Ser Asp Ile Glu Cys Val His Lys 
        115                 120                 125             


Glu Ser 
    130 


<210>  7
<211>  57
<212>  DNA
<213>  Homo sapiens

<400>  7
ggcatcatca taggagtcac agttgcagcc gtagtcttga ttgtggctgt gtttgtt          57


<210>  8
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  8

Gly Ile Ile Ile Gly Val Thr Val Ala Ala Val Val Leu Ile Val Ala 
1               5                   10                  15      


Val Phe Val 
            


<210>  9
<211>  669
<212>  DNA
<213>  Hybrid Homo sapiens X Rattus norvegicus


<220>
<221>  misc_feature
<222>  (307)..(486)
<223>  rat sequence

<400>  9
atggaacaac ggggacagaa cgccccggcc gcttcggggg cccggaaaag gcacggccca       60

ggacccaggg aggcgcgggg agccaggcct gggctccggg tccccaagac ccttgtgctc      120

gttgtcgccg cggtcctgct gttggtctca gctgagtctg ctctgatcac ccaacaagac      180

ctagctcccc agcagagagc ggccccacaa caaaagaggt ccagcccctc agagggattg      240

tgtccacctg gacaccatat ctcagaagac ggtagagatt gcatctcctg caaatatgga      300

caggactaca ccagcggtcc caacgtcctg ccttcctgcc tttcctgcag ggtctgtaag      360

gaagataaag tcataaaaag ccgatgcgtc aaagctagaa acacagagtg tgagtgcaaa      420

ccaggcagct ttgaagataa agactcgact gagatctgcc agacatgctc taacgggtgt      480

cccagaggga tggtcaaggt cggtgattgt acaccctgga gtgacatcga atgtgtccac      540

aaagaatcag gcatcatcat aggagtcaca gttgcagccg tagtcttgat tgtggctgtg      600

tttgtttgca agtctttact gtggaagaaa gtccttcctt acctgaaagg catctgctca      660

ggtggaggc                                                              669


<210>  10
<211>  223
<212>  PRT
<213>  Hybrid Homo sapiens X Rattus norvegicus

<400>  10

Met Glu Gln Arg Gly Gln Asn Ala Pro Ala Ala Ser Gly Ala Arg Lys 
1               5                   10                  15      


Arg His Gly Pro Gly Pro Arg Glu Ala Arg Gly Ala Arg Pro Gly Leu 
            20                  25                  30          


Arg Val Pro Lys Thr Leu Val Leu Val Val Ala Ala Val Leu Leu Leu 
        35                  40                  45              


Val Ser Ala Glu Ser Ala Leu Ile Thr Gln Gln Asp Leu Ala Pro Gln 
    50                  55                  60                  


Gln Arg Ala Ala Pro Gln Gln Lys Arg Ser Ser Pro Ser Glu Gly Leu 
65                  70                  75                  80  


Cys Pro Pro Gly His His Ile Ser Glu Asp Gly Arg Asp Cys Ile Ser 
                85                  90                  95      


Cys Lys Tyr Gly Gln Asp Tyr Thr Ser Gly Pro Asn Val Leu Pro Ser 
            100                 105                 110         


Cys Leu Ser Cys Arg Val Cys Lys Glu Asp Lys Val Ile Lys Ser Arg 
        115                 120                 125             


Cys Val Lys Ala Arg Asn Thr Glu Cys Glu Cys Lys Pro Gly Ser Phe 
    130                 135                 140                 


Glu Asp Lys Asp Ser Thr Glu Ile Cys Gln Thr Cys Ser Asn Gly Cys 
145                 150                 155                 160 


Pro Arg Gly Met Val Lys Val Gly Asp Cys Thr Pro Trp Ser Asp Ile 
                165                 170                 175     


Glu Cys Val His Lys Glu Ser Gly Ile Ile Ile Gly Val Thr Val Ala 
            180                 185                 190         


Ala Val Val Leu Ile Val Ala Val Phe Val Cys Lys Ser Leu Leu Trp 
        195                 200                 205             


Lys Lys Val Leu Pro Tyr Leu Lys Gly Ile Cys Ser Gly Gly Gly 
    210                 215                 220             


<210>  11
<211>  663
<212>  DNA
<213>  Mus musculus

<400>  11
atggagcctc caggacccag cacgcccaca gcctctgccg ctgcccgggc agatcactac       60

accccaggcc tccggccact cccgaagcgc agacttctat atagctttgc gttgctgctt      120

gctgtgctac aggctgtctt tgttccagta acagctaacc cagcccataa tcgtccagct      180

ggcctacagc ggccggagga gagcccatca agaggaccct gtctagcagg ccagtacctg      240

tcagaaggga actgcaagcc ttgcagagag ggtattgact acaccagcca ttccaaccat      300

tctctggatt catgtattct ctgcacagtc tgtaaggaag ataaagtcgt agaaacccga      360

tgcaacataa ccacaaatac ggtgtgtcga tgcaaaccag gcacctttga agataaagac      420

tcccctgaga tctgccagtc atgctctaac tgcactgacg gggaagagga actgacttcc      480

tgtaccccca gagaaaaccg gaagtgtgtc tccaaaacgg cttgggcatc ttggcataag      540

ctaggcctct ggataggact cctggttcca gtagtgctgc tgattggagc tctgcttgtc      600

tggaagactg gagcatggag gcaatggttg ctctgtataa aaagaggctg tgaacgggat      660

ccc                                                                    663


<210>  12
<211>  221
<212>  PRT
<213>  Mus musculus

<400>  12

Met Glu Pro Pro Gly Pro Ser Thr Pro Thr Ala Ser Ala Ala Ala Arg 
1               5                   10                  15      


Ala Asp His Tyr Thr Pro Gly Leu Arg Pro Leu Pro Lys Arg Arg Leu 
            20                  25                  30          


Leu Tyr Ser Phe Ala Leu Leu Leu Ala Val Leu Gln Ala Val Phe Val 
        35                  40                  45              


Pro Val Thr Ala Asn Pro Ala His Asn Arg Pro Ala Gly Leu Gln Arg 
    50                  55                  60                  


Pro Glu Glu Ser Pro Ser Arg Gly Pro Cys Leu Ala Gly Gln Tyr Leu 
65                  70                  75                  80  


Ser Glu Gly Asn Cys Lys Pro Cys Arg Glu Gly Ile Asp Tyr Thr Ser 
                85                  90                  95      


His Ser Asn His Ser Leu Asp Ser Cys Ile Leu Cys Thr Val Cys Lys 
            100                 105                 110         


Glu Asp Lys Val Val Glu Thr Arg Cys Asn Ile Thr Thr Asn Thr Val 
        115                 120                 125             


Cys Arg Cys Lys Pro Gly Thr Phe Glu Asp Lys Asp Ser Pro Glu Ile 
    130                 135                 140                 


Cys Gln Ser Cys Ser Asn Cys Thr Asp Gly Glu Glu Glu Leu Thr Ser 
145                 150                 155                 160 


Cys Thr Pro Arg Glu Asn Arg Lys Cys Val Ser Lys Thr Ala Trp Ala 
                165                 170                 175     


Ser Trp His Lys Leu Gly Leu Trp Ile Gly Leu Leu Val Pro Val Val 
            180                 185                 190         


Leu Leu Ile Gly Ala Leu Leu Val Trp Lys Thr Gly Ala Trp Arg Gln 
        195                 200                 205             


Trp Leu Leu Cys Ile Lys Arg Gly Cys Glu Arg Asp Pro 
    210                 215                 220     


<210>  13
<211>  669
<212>  DNA
<213>  Homo sapiens

<400>  13
atggaacaac ggggacagaa cgccccggcc gcttcggggg cccggaaaag gcacggccca       60

ggacccaggg aggcgcgggg agccaggcct gggctccggg tccccaagac ccttgtgctc      120

gttgtcgccg cggtcctgct gttggtctca gctgagtctg ctctgatcac ccaacaagac      180

ctagctcccc agcagagagc ggccccacaa caaaagaggt ccagcccctc agagggattg      240

tgtccacctg gacaccatat ctcagaagac ggtagagatt gcatctcctg caaatatgga      300

caggactata gcactcactg gaatgacctc cttttctgct tgcgctgcac caggtgtgat      360

tcaggtgaag tggagctaag tccctgcacc acgaccagaa acacagtgtg tcagtgcgaa      420

gaaggcacct tccgggaaga agattctcct gagatgtgcc ggaagtgccg cacagggtgt      480

cccagaggga tggtcaaggt cggtgattgt acaccctgga gtgacatcga atgtgtccac      540

aaagaatcag gcatcatcat aggagtcaca gttgcagccg tagtcttgat tgtggctgtg      600

tttgtttgca agtctttact gtggaagaaa gtccttcctt acctgaaagg catctgctca      660

ggtggaggc                                                              669


<210>  14
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Glu Gln Arg Gly Gln Asn Ala Pro Ala Ala Ser Gly Ala Arg Lys 
1               5                   10                  15      


Arg His Gly Pro Gly Pro Arg Glu Ala Arg Gly Ala Arg Pro Gly Leu 
            20                  25                  30          


Arg Val Pro Lys Thr Leu Val Leu Val Val Ala Ala Val Leu Leu Leu 
        35                  40                  45              


Val Ser Ala Glu Ser Ala Leu Ile Thr Gln Gln Asp Leu Ala Pro Gln 
    50                  55                  60                  


Gln Arg Ala Ala Pro Gln Gln Lys Arg Ser Ser Pro Ser Glu Gly Leu 
65                  70                  75                  80  


Cys Pro Pro Gly His His Ile Ser Glu Asp Gly Arg Asp Cys Ile Ser 
                85                  90                  95      


Cys Lys Tyr Gly Gln Asp Tyr Ser Thr His Trp Asn Asp Leu Leu Phe 
            100                 105                 110         


Cys Leu Arg Cys Thr Arg Cys Asp Ser Gly Glu Val Glu Leu Ser Pro 
        115                 120                 125             


Cys Thr Thr Thr Arg Asn Thr Val Cys Gln Cys Glu Glu Gly Thr Phe 
    130                 135                 140                 


Arg Glu Glu Asp Ser Pro Glu Met Cys Arg Lys Cys Arg Thr Gly Cys 
145                 150                 155                 160 


Pro Arg Gly Met Val Lys Val Gly Asp Cys Thr Pro Trp Ser Asp Ile 
                165                 170                 175     


Glu Cys Val His Lys Glu Ser Gly Ile Ile Ile Gly Val Thr Val Ala 
            180                 185                 190         


Ala Val Val Leu Ile Val Ala Val Phe Val Cys Lys Ser Leu Leu Trp 
        195                 200                 205             


Lys Lys Val Leu Pro Tyr Leu Lys Gly Ile Cys Ser Gly Gly Gly 
    210                 215                 220             


<210>  15
<211>  1449
<212>  DNA
<213>  Mus musculus

<400>  15
atggagcctc caggacccag cacgcccaca gcctctgccg ctgcccgggc agatcactac       60

accccaggcc tccggccact cccgaagcgc agacttctat atagctttgc gttgctgctt      120

gctgtgctac aggctgtctt tgttccagta acagctaacc cagcccataa tcgtccagct      180

ggcctacagc ggccggagga gagcccatca agaggaccct gtctagcagg ccagtacctg      240

tcagaaggga actgcaagcc ttgcagagag ggtattgact acaccagcca ttccaaccat      300

tctctggatt catgtattct ctgcacagtc tgtaaggaag ataaagtcgt agaaacccga      360

tgcaacataa ccacaaatac ggtgtgtcga tgcaaaccag gcacctttga agataaagac      420

tcccctgaga tctgccagtc atgctctaac tgcactgacg gggaagagga actgacttcc      480

tgtaccccca gagaaaaccg gaagtgtgtc tccaaaacgg cttgggcatc ttggcataag      540

ctaggcctct ggataggact cctggttcca gtagtgctgc tgattggagc tctgcttgtc      600

tggaagactg gagcatggag gcaatggttg ctctgtataa aaagaggctg tgaacgggat      660

ccactagtcc agtgtggtgg aatggaaaac cttgattgtt gggtcgacaa cgaagaagac      720

atcgatgtta tcctgaaaaa gtctaccatt ctgaacttgg acatcaacaa cgatattatc      780

tccgacatct ctggtttcaa ctcctctgtt atcacatatc cagatgctca attggtgccg      840

ggcatcaacg gcaaagctat ccacctggtt aacaacgaat cttctgaagt tatcgtgcac      900

aaggccatgg acatcgaata caacgacatg ttcaacaact tcaccgttag cttctggctg      960

cgcgttccga aagtttctgc ttcccacctg gaacagtacg gcactaacga gtactccatc     1020

atcagctcta tgaagaaaca ctccctgtcc atcggctctg gttggtctgt ttccctgaag     1080

ggtaacaacc tgatctggac tctgaaagac tccgcgggcg aagttcgtca gatcactttc     1140

cgcgacctgc cggacaagtt caacgcgtac ctggctaaca aatgggtttt catcactatc     1200

actaacgatc gtctgtcttc tgctaacctg tacatcaacg gcgttctgat gggctccgct     1260

gaaatcactg gtctgggcgc tatccgtgag gacaacaaca tcactcttaa gctggaccgt     1320

tgcaacaaca acaaccagta cgtatccatc gacaagttcc gtatcttctg caaagcactg     1380

aacccgaaag agatcgaaaa actgtatacc agctacctgt ctatcacctt cctgcgtgac     1440

ttctggggt                                                             1449


<210>  16
<211>  483
<212>  PRT
<213>  Mus musculus

<400>  16

Met Glu Pro Pro Gly Pro Ser Thr Pro Thr Ala Ser Ala Ala Ala Arg 
1               5                   10                  15      


Ala Asp His Tyr Thr Pro Gly Leu Arg Pro Leu Pro Lys Arg Arg Leu 
            20                  25                  30          


Leu Tyr Ser Phe Ala Leu Leu Leu Ala Val Leu Gln Ala Val Phe Val 
        35                  40                  45              


Pro Val Thr Ala Asn Pro Ala His Asn Arg Pro Ala Gly Leu Gln Arg 
    50                  55                  60                  


Pro Glu Glu Ser Pro Ser Arg Gly Pro Cys Leu Ala Gly Gln Tyr Leu 
65                  70                  75                  80  


Ser Glu Gly Asn Cys Lys Pro Cys Arg Glu Gly Ile Asp Tyr Thr Ser 
                85                  90                  95      


His Ser Asn His Ser Leu Asp Ser Cys Ile Leu Cys Thr Val Cys Lys 
            100                 105                 110         


Glu Asp Lys Val Val Glu Thr Arg Cys Asn Ile Thr Thr Asn Thr Val 
        115                 120                 125             


Cys Arg Cys Lys Pro Gly Thr Phe Glu Asp Lys Asp Ser Pro Glu Ile 
    130                 135                 140                 


Cys Gln Ser Cys Ser Asn Cys Thr Asp Gly Glu Glu Glu Leu Thr Ser 
145                 150                 155                 160 


Cys Thr Pro Arg Glu Asn Arg Lys Cys Val Ser Lys Thr Ala Trp Ala 
                165                 170                 175     


Ser Trp His Lys Leu Gly Leu Trp Ile Gly Leu Leu Val Pro Val Val 
            180                 185                 190         


Leu Leu Ile Gly Ala Leu Leu Val Trp Lys Thr Gly Ala Trp Arg Gln 
        195                 200                 205             


Trp Leu Leu Cys Ile Lys Arg Gly Cys Glu Arg Asp Pro Leu Val Gln 
    210                 215                 220                 


Cys Gly Gly Met Glu Asn Leu Asp Cys Trp Val Asp Asn Glu Glu Asp 
225                 230                 235                 240 


Ile Asp Val Ile Leu Lys Lys Ser Thr Ile Leu Asn Leu Asp Ile Asn 
                245                 250                 255     


Asn Asp Ile Ile Ser Asp Ile Ser Gly Phe Asn Ser Ser Val Ile Thr 
            260                 265                 270         


Tyr Pro Asp Ala Gln Leu Val Pro Gly Ile Asn Gly Lys Ala Ile His 
        275                 280                 285             


Leu Val Asn Asn Glu Ser Ser Glu Val Ile Val His Lys Ala Met Asp 
    290                 295                 300                 


Ile Glu Tyr Asn Asp Met Phe Asn Asn Phe Thr Val Ser Phe Trp Leu 
305                 310                 315                 320 


Arg Val Pro Lys Val Ser Ala Ser His Leu Glu Gln Tyr Gly Thr Asn 
                325                 330                 335     


Glu Tyr Ser Ile Ile Ser Ser Met Lys Lys His Ser Leu Ser Ile Gly 
            340                 345                 350         


Ser Gly Trp Ser Val Ser Leu Lys Gly Asn Asn Leu Ile Trp Thr Leu 
        355                 360                 365             


Lys Asp Ser Ala Gly Glu Val Arg Gln Ile Thr Phe Arg Asp Leu Pro 
    370                 375                 380                 


Asp Lys Phe Asn Ala Tyr Leu Ala Asn Lys Trp Val Phe Ile Thr Ile 
385                 390                 395                 400 


Thr Asn Asp Arg Leu Ser Ser Ala Asn Leu Tyr Ile Asn Gly Val Leu 
                405                 410                 415     


Met Gly Ser Ala Glu Ile Thr Gly Leu Gly Ala Ile Arg Glu Asp Asn 
            420                 425                 430         


Asn Ile Thr Leu Lys Leu Asp Arg Cys Asn Asn Asn Asn Gln Tyr Val 
        435                 440                 445             


Ser Ile Asp Lys Phe Arg Ile Phe Cys Lys Ala Leu Asn Pro Lys Glu 
    450                 455                 460                 


Ile Glu Lys Leu Tyr Thr Ser Tyr Leu Ser Ile Thr Phe Leu Arg Asp 
465                 470                 475                 480 


Phe Trp Gly 
            


<210>  17
<211>  1412
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(663)
<223>  mDR5ectm w/signal peptide

<220>
<221>  misc_feature
<222>  (693)..(1412)
<223>  eGFP

<400>  17
atggagcctc caggacccag cacgcccaca gcctctgccg ctgcccgggc agatcactac       60

accccaggcc tccggccact cccgaagcgc agacttctat atagctttgc gttgctgctt      120

gctgtgctac aggctgtctt tgttccagta acagctaacc cagcccataa tcgtccagct      180

ggcctacagc ggccggagga gagcccatca agaggaccct gtctagcagg ccagtacctg      240

tcagaaggga actgcaagcc ttgcagagag ggtattgact acaccagcca ttccaaccat      300

tctctggatt catgtattct ctgcacagtc tgtaaggaag ataaagtcgt agaaacccga      360

tgcaacataa ccacaaatac ggtgtgtcga tgcaaaccag gcacctttga agataaagac      420

tcccctgaga tctgccagtc atgctctaac tgcactgacg gggaagagga actgacttcc      480

tgtaccccca gagaaaaccg gaagtgtgtc tccaaaacgg cttgggcatc ttggcataag      540

ctaggcctct ggataggact cctggttcca gtagtgctgc tgattggagc tctgcttgtc      600

tggaagactg gagcatggag gcaatggttg ctctgtataa aaagaggctg tgaacgggat      660

cggtgaccgc ggtcaccgat ccaccggtcg ccaccatggt gagcaagggc gaggagctgt      720

tcaccggggt ggtgcccatc ctggtcgagc tggacggcga cgtaaacggc cacaagttca      780

gcgtgtccgg cgagggcgag ggcgatgcca cctacggcaa gctgaccctg aagttcatct      840

gcaccaccgg caagctgccc gtgccctggc ccaccctcgt gaccaccctg acctacggcg      900

tgcagtgctt cagccgctac cccgaccaca tgaagcagca cgacttcttc aagtccgcca      960

tgcccgaagg ctacgtccag gagcgcacca tcttcttcaa ggacgacggc aactacaaga     1020

cccgcgccga ggtgaagttc gagggcgaca ccctggtgaa ccgcatcgag ctgaagggca     1080

tcgacttcaa ggaggacggc aacatcctgg ggcacaagct ggagtacaac tacaacagcc     1140

acaacgtcta tatcatggcc gacaagcaga agaacggcat caaggtgaac ttcaagatcc     1200

gccacaacat cgaggacggc agcgtgcagc tcgccgacca ctaccagcag aacaccccca     1260

tcggcgacgg ccccgtgctg ctgcccgaca accactacct gagcacccag tccgccctga     1320

gcaaagaccc caacgagaag cgcgatcaca tggtcctgct ggagttcgtg accgccgccg     1380

ggatcactct cggcatggac gagctgtaca ag                                   1412


<210>  18
<211>  460
<212>  PRT
<213>  Mus musculus


<220>
<221>  PEPTIDE
<222>  (1)..(221)
<223>  mDR5ectm

<220>
<221>  PEPTIDE
<222>  (222)..(460)
<223>  eGFP

<400>  18

Met Glu Pro Pro Gly Pro Ser Thr Pro Thr Ala Ser Ala Ala Ala Arg 
1               5                   10                  15      


Ala Asp His Tyr Thr Pro Gly Leu Arg Pro Leu Pro Lys Arg Arg Leu 
            20                  25                  30          


Leu Tyr Ser Phe Ala Leu Leu Leu Ala Val Leu Gln Ala Val Phe Val 
        35                  40                  45              


Pro Val Thr Ala Asn Pro Ala His Asn Arg Pro Ala Gly Leu Gln Arg 
    50                  55                  60                  


Pro Glu Glu Ser Pro Ser Arg Gly Pro Cys Leu Ala Gly Gln Tyr Leu 
65                  70                  75                  80  


Ser Glu Gly Asn Cys Lys Pro Cys Arg Glu Gly Ile Asp Tyr Thr Ser 
                85                  90                  95      


His Ser Asn His Ser Leu Asp Ser Cys Ile Leu Cys Thr Val Cys Lys 
            100                 105                 110         


Glu Asp Lys Val Val Glu Thr Arg Cys Asn Ile Thr Thr Asn Thr Val 
        115                 120                 125             


Cys Arg Cys Lys Pro Gly Thr Phe Glu Asp Lys Asp Ser Pro Glu Ile 
    130                 135                 140                 


Cys Gln Ser Cys Ser Asn Cys Thr Asp Gly Glu Glu Glu Leu Thr Ser 
145                 150                 155                 160 


Cys Thr Pro Arg Glu Asn Arg Lys Cys Val Ser Lys Thr Ala Trp Ala 
                165                 170                 175     


Ser Trp His Lys Leu Gly Leu Trp Ile Gly Leu Leu Val Pro Val Val 
            180                 185                 190         


Leu Leu Ile Gly Ala Leu Leu Val Trp Lys Thr Gly Ala Trp Arg Gln 
        195                 200                 205             


Trp Leu Leu Cys Ile Lys Arg Gly Cys Glu Arg Asp Arg Met Val Ser 
    210                 215                 220                 


Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu 
225                 230                 235                 240 


Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu 
                245                 250                 255     


Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr 
            260                 265                 270         


Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr 
        275                 280                 285             


Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His Asp 
    290                 295                 300                 


Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile 
305                 310                 315                 320 


Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe 
                325                 330                 335     


Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe 
            340                 345                 350         


Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn 
        355                 360                 365             


Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys 
    370                 375                 380                 


Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu 
385                 390                 395                 400 


Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu 
                405                 410                 415     


Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp 
            420                 425                 430         


Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala 
        435                 440                 445             


Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
    450                 455                 460 


<210>  19
<211>  660
<212>  DNA
<213>  Hybrid Mus Musculus X Rattus norvegicus


<220>
<221>  misc_feature
<222>  (280)..(444)
<223>  Rat sequence

<400>  19
atggagcctc caggacccag cacgcccaca gcctctgccg ctgcccgggc agatcactac       60

accccaggcc tccggccact cccgaagcgc agacttctat atagctttgc gttgctgctt      120

gctatgctac aggctgtctt tgttccagta acagctaacc cagcccataa tcgtccagct      180

ggcctacagc ggccggagga gagcccatca agaggaccct gtctagcagg ccagtacctg      240

tcagaaggga actgcaagcc ttgcagagag ggtattgact acaccagcgg tcccaacgtc      300

ctgccttcct gcctttcctg cagggtctgt aaggaagata aagtcataaa aagccgatgc      360

gtcaaagcta gaaacacaga gtgtgagtgc aaaccaggca gctttgaaga taaagactcg      420

actgagatct gccagacatg ctctaactgc actgacgggg aagaggaact gacttcctgt      480

acccccagag aaaaccggaa gtgtgtctcc aaaacggctt gggcatcttg gcataagcta      540

ggcctctgga taggactcct ggttccagta gtgctgctga ttggagctct gcttgtctgg      600

aagactggag catggaggca atggttgctc tgtataaaaa gaggctgtga acgggatcca      660


<210>  20
<211>  220
<212>  PRT
<213>  Hybrid Mus Musculus X Rattus norvegicus

<400>  20

Met Glu Pro Pro Gly Pro Ser Thr Pro Thr Ala Ser Ala Ala Ala Arg 
1               5                   10                  15      


Ala Asp His Tyr Thr Pro Gly Leu Arg Pro Leu Pro Lys Arg Arg Leu 
            20                  25                  30          


Leu Tyr Ser Phe Ala Leu Leu Leu Ala Met Leu Gln Ala Val Phe Val 
        35                  40                  45              


Pro Val Thr Ala Asn Pro Ala His Asn Arg Pro Ala Gly Leu Gln Arg 
    50                  55                  60                  


Pro Glu Glu Ser Pro Ser Arg Gly Pro Cys Leu Ala Gly Gln Tyr Leu 
65                  70                  75                  80  


Ser Glu Gly Asn Cys Lys Pro Cys Arg Glu Gly Ile Asp Tyr Thr Ser 
                85                  90                  95      


Gly Pro Asn Val Leu Pro Ser Cys Leu Ser Cys Arg Val Cys Lys Glu 
            100                 105                 110         


Asp Lys Val Ile Lys Ser Arg Cys Val Lys Ala Arg Asn Thr Glu Cys 
        115                 120                 125             


Glu Cys Lys Pro Gly Ser Phe Glu Asp Lys Asp Ser Thr Glu Ile Cys 
    130                 135                 140                 


Gln Thr Cys Ser Asn Cys Thr Asp Gly Glu Glu Glu Leu Thr Ser Cys 
145                 150                 155                 160 


Thr Pro Arg Glu Asn Arg Lys Cys Val Ser Lys Thr Ala Trp Ala Ser 
                165                 170                 175     


Trp His Lys Leu Gly Leu Trp Ile Gly Leu Leu Val Pro Val Val Leu 
            180                 185                 190         


Leu Ile Gly Ala Leu Leu Val Trp Lys Thr Gly Ala Trp Arg Gln Trp 
        195                 200                 205             


Leu Leu Cys Ile Lys Arg Gly Cys Glu Arg Asp Pro 
    210                 215                 220 


<210>  21
<211>  1233
<212>  DNA
<213>  Homo sapiens

<400>  21
atggaacaac ggggacagaa cgccccggcc gcttcggggg cccggaaaag gcacggccca       60

ggacccaggg aggcgcgggg agccaggcct gggctccggg tccccaagac ccttgtgctc      120

gttgtcgccg cggtcctgct gttggtctca gctgagtctg ctctgatcac ccaacaagac      180

ctagctcccc agcagagagc ggccccacaa caaaagaggt ccagcccctc agagggattg      240

tgtccacctg gacaccatat ctcagaagac ggtagagatt gcatctcctg caaatatgga      300

caggactata gcactcactg gaatgacctc cttttctgct tgcgctgcac caggtgtgat      360

tcaggtgaag tggagctaag tccctgcacc acgaccagaa acacagtgtg tcagtgcgaa      420

gaaggcacct tccgggaaga agattctcct gagatgtgcc ggaagtgccg cacagggtgt      480

cccagaggga tggtcaaggt cggtgattgt acaccctgga gtgacatcga atgtgtccac      540

aaagaatcag gcatcatcat aggagtcaca gttgcagccg tagtcttgat tgtggctgtg      600

tttgtttgca agtctttact gtggaagaaa gtccttcctt acctgaaagg catctgctca      660

ggtggaggcg gggaccctga gcgtgtggac agaagctcac aacgacctgg ggctgaggac      720

aatgtcctca atgagatcgt gagtatcttg cagcccaccc aggtccctga gcaggaaatg      780

gaagtccagg agccagcaga gccaacaggt gtcaacatgt tgtcccccgg ggagtcagag      840

catctgctgg aaccggcaga agctgaaagg tctcagagga ggaggctgct ggttccagca      900

aatgaaggtg atcccactga gactctgaga cagtgcttcg atgactttgc agacttggtg      960

ccctttgact cctgggagcc gctcatgagg aagttgggcc tcatggacaa tgagataaag     1020

gtggctaaag ctgaggcagc gggccacagg gacaccttgt acacgatgct gataaagtgg     1080

gtcaacaaaa ccgggcgaga tgcctctgtc cacaccctgc tggatgcctt ggagacgctg     1140

ggagagagac ttgccaagca gaagattgag gaccacttgt tgagctctgg aaagttcatg     1200

tatctagaag gtaatgcaga ctctgccatg tcc                                  1233


<210>  22
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Glu Gln Arg Gly Gln Asn Ala Pro Ala Ala Ser Gly Ala Arg Lys 
1               5                   10                  15      


Arg His Gly Pro Gly Pro Arg Glu Ala Arg Gly Ala Arg Pro Gly Leu 
            20                  25                  30          


Arg Val Pro Lys Thr Leu Val Leu Val Val Ala Ala Val Leu Leu Leu 
        35                  40                  45              


Val Ser Ala Glu Ser Ala Leu Ile Thr Gln Gln Asp Leu Ala Pro Gln 
    50                  55                  60                  


Gln Arg Ala Ala Pro Gln Gln Lys Arg Ser Ser Pro Ser Glu Gly Leu 
65                  70                  75                  80  


Cys Pro Pro Gly His His Ile Ser Glu Asp Gly Arg Asp Cys Ile Ser 
                85                  90                  95      


Cys Lys Tyr Gly Gln Asp Tyr Ser Thr His Trp Asn Asp Leu Leu Phe 
            100                 105                 110         


Cys Leu Arg Cys Thr Arg Cys Asp Ser Gly Glu Val Glu Leu Ser Pro 
        115                 120                 125             


Cys Thr Thr Thr Arg Asn Thr Val Cys Gln Cys Glu Glu Gly Thr Phe 
    130                 135                 140                 


Arg Glu Glu Asp Ser Pro Glu Met Cys Arg Lys Cys Arg Thr Gly Cys 
145                 150                 155                 160 


Pro Arg Gly Met Val Lys Val Gly Asp Cys Thr Pro Trp Ser Asp Ile 
                165                 170                 175     


Glu Cys Val His Lys Glu Ser Gly Ile Ile Ile Gly Val Thr Val Ala 
            180                 185                 190         


Ala Val Val Leu Ile Val Ala Val Phe Val Cys Lys Ser Leu Leu Trp 
        195                 200                 205             


Lys Lys Val Leu Pro Tyr Leu Lys Gly Ile Cys Ser Gly Gly Gly Gly 
    210                 215                 220                 


Asp Pro Glu Arg Val Asp Arg Ser Ser Gln Arg Pro Gly Ala Glu Asp 
225                 230                 235                 240 


Asn Val Leu Asn Glu Ile Val Ser Ile Leu Gln Pro Thr Gln Val Pro 
                245                 250                 255     


Glu Gln Glu Met Glu Val Gln Glu Pro Ala Glu Pro Thr Gly Val Asn 
            260                 265                 270         


Met Leu Ser Pro Gly Glu Ser Glu His Leu Leu Glu Pro Ala Glu Ala 
        275                 280                 285             


Glu Arg Ser Gln Arg Arg Arg Leu Leu Val Pro Ala Asn Glu Gly Asp 
    290                 295                 300                 


Pro Thr Glu Thr Leu Arg Gln Cys Phe Asp Asp Phe Ala Asp Leu Val 
305                 310                 315                 320 


Pro Phe Asp Ser Trp Glu Pro Leu Met Arg Lys Leu Gly Leu Met Asp 
                325                 330                 335     


Asn Glu Ile Lys Val Ala Lys Ala Glu Ala Ala Gly His Arg Asp Thr 
            340                 345                 350         


Leu Tyr Thr Met Leu Ile Lys Trp Val Asn Lys Thr Gly Arg Asp Ala 
        355                 360                 365             


Ser Val His Thr Leu Leu Asp Ala Leu Glu Thr Leu Gly Glu Arg Leu 
    370                 375                 380                 


Ala Lys Gln Lys Ile Glu Asp His Leu Leu Ser Ser Gly Lys Phe Met 
385                 390                 395                 400 


Tyr Leu Glu Gly Asn Ala Asp Ser Ala Met Ser 
                405                 410     


<210>  23
<211>  1443
<212>  DNA
<213>  Homo sapiens

<400>  23
atggaacaac ggggacagaa cgccccggcc gcttcggggg cccggaaaag gcacggccca       60

ggacccaggg aggcgcgggg agccaggcct gggccccggg tccccaagac ccttgtgctc      120

gttgtcgccg cggtcctgct gttggtctca gctgagtctg ctctgatcac ccaacaagac      180

ctagctcccc agcagagagc ggccccacaa caaaagaggt ccagcccctc agagggattg      240

tgtccacctg gacaccatat ctcagaagac ggtagagatt gcatctcctg caaatatgga      300

caggactata gcactcactg gaatgacctc cttttctgct tgcgctgcac caggtgtgat      360

tcaggtgaag tggagctaag tccctgcacc acgaccagaa acacagtgtg tcagtgcgaa      420

gaaggcacct tccgggaaga agattctcct gagatgtgcc ggaagtgccg cacagggtgt      480

cccagaggga tggtcaaggt cggtgattgt acaccctgga gtgacatcga atgtgtccac      540

aaagaatcag gcatcatcat aggagtcaca gttgcagccg tagtcttgat tgtggctgtg      600

tttgtttgca agtctttact gtggaagaaa gtccttcctt acctgaaagg catctgctca      660

ggtggaggca aaaaccttga ttgttgggtc gacaacgaag aagacatcga tgttatcctg      720

aaaaagtcta ccattctgaa cttggacatc aacaacgata ttatctccga catctctggt      780

ttcaactcct ctgttatcac atatccagat gctcaattgg tgccgggcat caacggcaaa      840

gctatccacc tggttaacaa cgaatcttct gaagttatcg tgcacaaggc catggacatc      900

gaatacaacg acatgttcaa caacttcacc gttagcttct ggctgcgcgt tccgaaagtt      960

tctgcttccc acctggaaca gtacggcact aacgagtact ccatcatcag ctctatgaag     1020

aaacactccc tgtccatcgg ctctggttgg tctgtttccc tgaagggtaa caacctgatc     1080

tggactctga aagactccgc gggcgaagtt cgtcagatca ctttccgcga cctgccggac     1140

aagttcaacg cgtacctggc taacaaatgg gttttcatca ctatcactaa cgatcgtctg     1200

tcttctgcta acctgtacat caacggcgtt ctgatgggct ccgctgaaat cactggtctg     1260

ggcgctatcc gtgaggacaa caacatcact cttaagctgg accgttgcaa caacaacaac     1320

cagtacgtat ccatcgacaa gttccgtatc ttctgcaaag cactgaaccc gaaagagatc     1380

gaaaaactgt ataccagcta cctgtctatc accttcctgc gtgacttctg gggtaacccg     1440

ctg                                                                   1443


<210>  24
<211>  481
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Glu Gln Arg Gly Gln Asn Ala Pro Ala Ala Ser Gly Ala Arg Lys 
1               5                   10                  15      


Arg His Gly Pro Gly Pro Arg Glu Ala Arg Gly Ala Arg Pro Gly Pro 
            20                  25                  30          


Arg Val Pro Lys Thr Leu Val Leu Val Val Ala Ala Val Leu Leu Leu 
        35                  40                  45              


Val Ser Ala Glu Ser Ala Leu Ile Thr Gln Gln Asp Leu Ala Pro Gln 
    50                  55                  60                  


Gln Arg Ala Ala Pro Gln Gln Lys Arg Ser Ser Pro Ser Glu Gly Leu 
65                  70                  75                  80  


Cys Pro Pro Gly His His Ile Ser Glu Asp Gly Arg Asp Cys Ile Ser 
                85                  90                  95      


Cys Lys Tyr Gly Gln Asp Tyr Ser Thr His Trp Asn Asp Leu Leu Phe 
            100                 105                 110         


Cys Leu Arg Cys Thr Arg Cys Asp Ser Gly Glu Val Glu Leu Ser Pro 
        115                 120                 125             


Cys Thr Thr Thr Arg Asn Thr Val Cys Gln Cys Glu Glu Gly Thr Phe 
    130                 135                 140                 


Arg Glu Glu Asp Ser Pro Glu Met Cys Arg Lys Cys Arg Thr Gly Cys 
145                 150                 155                 160 


Pro Arg Gly Met Val Lys Val Gly Asp Cys Thr Pro Trp Ser Asp Ile 
                165                 170                 175     


Glu Cys Val His Lys Glu Ser Gly Ile Ile Ile Gly Val Thr Val Ala 
            180                 185                 190         


Ala Val Val Leu Ile Val Ala Val Phe Val Cys Lys Ser Leu Leu Trp 
        195                 200                 205             


Lys Lys Val Leu Pro Tyr Leu Lys Gly Ile Cys Ser Gly Gly Gly Lys 
    210                 215                 220                 


Asn Leu Asp Cys Trp Val Asp Asn Glu Glu Asp Ile Asp Val Ile Leu 
225                 230                 235                 240 


Lys Lys Ser Thr Ile Leu Asn Leu Asp Ile Asn Asn Asp Ile Ile Ser 
                245                 250                 255     


Asp Ile Ser Gly Phe Asn Ser Ser Val Ile Thr Tyr Pro Asp Ala Gln 
            260                 265                 270         


Leu Val Pro Gly Ile Asn Gly Lys Ala Ile His Leu Val Asn Asn Glu 
        275                 280                 285             


Ser Ser Glu Val Ile Val His Lys Ala Met Asp Ile Glu Tyr Asn Asp 
    290                 295                 300                 


Met Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val 
305                 310                 315                 320 


Ser Ala Ser His Leu Glu Gln Tyr Gly Thr Asn Glu Tyr Ser Ile Ile 
                325                 330                 335     


Ser Ser Met Lys Lys His Ser Leu Ser Ile Gly Ser Gly Trp Ser Val 
            340                 345                 350         


Ser Leu Lys Gly Asn Asn Leu Ile Trp Thr Leu Lys Asp Ser Ala Gly 
        355                 360                 365             


Glu Val Arg Gln Ile Thr Phe Arg Asp Leu Pro Asp Lys Phe Asn Ala 
    370                 375                 380                 


Tyr Leu Ala Asn Lys Trp Val Phe Ile Thr Ile Thr Asn Asp Arg Leu 
385                 390                 395                 400 


Ser Ser Ala Asn Leu Tyr Ile Asn Gly Val Leu Met Gly Ser Ala Glu 
                405                 410                 415     


Ile Thr Gly Leu Gly Ala Ile Arg Glu Asp Asn Asn Ile Thr Leu Lys 
            420                 425                 430         


Leu Asp Arg Cys Asn Asn Asn Asn Gln Tyr Val Ser Ile Asp Lys Phe 
        435                 440                 445             


Arg Ile Phe Cys Lys Ala Leu Asn Pro Lys Glu Ile Glu Lys Leu Tyr 
    450                 455                 460                 


Thr Ser Tyr Leu Ser Ile Thr Phe Leu Arg Asp Phe Trp Gly Asn Pro 
465                 470                 475                 480 


Leu 
    


<210>  25
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  25
atatctacaa gcttgcgacc atggaacaac ggggacaga                              39


<210>  26
<211>  34
<212>  DNA
<213>  Homo sapiens

<400>  26
ctagatggat cctcagcctc cacctgagca gatg                                   34


<210>  27
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  27
atatctacaa gcttgcgacc atggaacaac ggggacaga                              39


<210>  28
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  28
ctagatggat ccttaggaca tggcagagtc tgc                                    33


<210>  29
<211>  34
<212>  DNA
<213>  Homo sapiens

<400>  29
ctagatggat cctcagcctc cacctgagca gatg                                   34


<210>  30
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  30
ccaacaatca aggtttttgc ctccacctga gcagat                                 36


<210>  31
<211>  26
<212>  DNA
<213>  Homo sapiens

<400>  31
gtggaggcaa aaaccttgat tgttgg                                            26


<210>  32
<211>  34
<212>  DNA
<213>  Homo sapiens

<400>  32
ctagatggat cctcacagcg ggttacccca gaag                                   34


