                               SEQUENCE LISTING                               

<110> Chen, Xi
      Fan, Pinchen
      Gleason, Mark M.
      Jaen, Juan C.
      Li, Lianfa
      McMahon, Jeffrey P.
      Powers, Jay
      Zeng, Yibin
      Zhang, Penglie
      ChemoCentryx, Inc.

<120> Modulators of CXCR7

<130> 019934-008110PC

<140> WO PCT/US09/63298
<141> 2009-11-04

<150> US 61/111,251
<151> 2008-11-04

<150> US 61/219,341
<151> 2009-06-22

<160> 12                            

<170> PatentIn Ver. 2.1

<210> 1
<211> 1089
<212> DNA
<213> Homo sapiens

<220> 
<223> human chemokine receptor CXCR7 (RDC1, CCXCKR2)

<400> 1
atggatctgc atctcttcga ctactcagag ccagggaact tctcggacat cagctggcca 60    
tgcaacagca gcgactgcat cgtggtggac acggtgatgt gtcccaacat gcccaacaaa 120   
agcgtcctgc tctacacgct ctccttcatt tacattttca tcttcgtcat cggcatgatt 180   
gccaactccg tggtggtctg ggtgaatatc caggccaaga ccacaggcta tgacacgcac 240   
tgctacatct tgaacctggc cattgccgac ctgtgggttg tcctcaccat cccagtctgg 300   
gtggtcagtc tcgtgcagca caaccagtgg cccatgggcg agctcacgtg caaagtcaca 360   
cacctcatct tctccatcaa cctcttcggc agcattttct tcctcacgtg catgagcgtg 420   
gaccgctacc tctccatcac ctacttcacc aacaccccca gcagcaggaa gaagatggta 480   
cgccgtgtcg tctgcatcct ggtgtggctg ctggccttct gcgtgtctct gcctgacacc 540   
tactacctga agaccgtcac gtctgcgtcc aacaatgaga cctactgccg gtccttctac 600   
cccgagcaca gcatcaagga gtggctgatc ggcatggagc tggtctccgt tgtcttgggc 660   
tttgccgttc ccttctccat tatcgctgtc ttctacttcc tgctggccag agccatctcg 720   
gcgtccagtg accaggagaa gcacagcagc cggaagatca tcttctccta cgtggtggtc 780   
ttccttgtct gctggctgcc ctaccacgtg gcggtgctgc tggacatctt ctccatcctg 840   
cactacatcc ctttcacctg ccggctggag cacgccctct tcacggccct gcatgtcaca 900   
cagtgcctgt cgctggtgca ctgctgcgtc aaccctgtcc tctacagctt catcaatcgc 960   
aactacaggt acgagctgat gaaggccttc atcttcaagt actcggccaa aacagggctc 1020  
accaagctca tcgatgcctc cagagtctca gagacggagt actctgcctt ggagcagagc 1080  
accaaatga                                                         1089  


<210> 2
<211> 362
<212> PRT
<213> Homo sapiens

<220> 
<223> human chemokine receptor CXCR7 (RDC1, CCXCKR2)

<400> 2
Met Asp Leu His Leu Phe Asp Tyr Ser Glu Pro Gly Asn Phe Ser Asp  
  1               5                  10                  15    

Ile Ser Trp Pro Cys Asn Ser Ser Asp Cys Ile Val Val Asp Thr Val  
             20                  25                  30        

Met Cys Pro Asn Met Pro Asn Lys Ser Val Leu Leu Tyr Thr Leu Ser  
         35                  40                  45            

Phe Ile Tyr Ile Phe Ile Phe Val Ile Gly Met Ile Ala Asn Ser Val  
     50                  55                  60                

Val Val Trp Val Asn Ile Gln Ala Lys Thr Thr Gly Tyr Asp Thr His  
 65                  70                  75                  80

Cys Tyr Ile Leu Asn Leu Ala Ile Ala Asp Leu Trp Val Val Leu Thr  
                 85                  90                  95    

Ile Pro Val Trp Val Val Ser Leu Val Gln His Asn Gln Trp Pro Met  
            100                 105                 110        

Gly Glu Leu Thr Cys Lys Val Thr His Leu Ile Phe Ser Ile Asn Leu  
        115                 120                 125            

Phe Gly Ser Ile Phe Phe Leu Thr Cys Met Ser Val Asp Arg Tyr Leu  
    130                 135                 140                

Ser Ile Thr Tyr Phe Thr Asn Thr Pro Ser Ser Arg Lys Lys Met Val  
145                 150                 155                 160

Arg Arg Val Val Cys Ile Leu Val Trp Leu Leu Ala Phe Cys Val Ser  
                165                 170                 175    

Leu Pro Asp Thr Tyr Tyr Leu Lys Thr Val Thr Ser Ala Ser Asn Asn  
            180                 185                 190        

Glu Thr Tyr Cys Arg Ser Phe Tyr Pro Glu His Ser Ile Lys Glu Trp  
        195                 200                 205            

Leu Ile Gly Met Glu Leu Val Ser Val Val Leu Gly Phe Ala Val Pro  
    210                 215                 220                

Phe Ser Ile Ile Ala Val Phe Tyr Phe Leu Leu Ala Arg Ala Ile Ser  
225                 230                 235                 240

Ala Ser Ser Asp Gln Glu Lys His Ser Ser Arg Lys Ile Ile Phe Ser  
                245                 250                 255    

Tyr Val Val Val Phe Leu Val Cys Trp Leu Pro Tyr His Val Ala Val  
            260                 265                 270        

Leu Leu Asp Ile Phe Ser Ile Leu His Tyr Ile Pro Phe Thr Cys Arg  
        275                 280                 285            

Leu Glu His Ala Leu Phe Thr Ala Leu His Val Thr Gln Cys Leu Ser  
    290                 295                 300                

Leu Val His Cys Cys Val Asn Pro Val Leu Tyr Ser Phe Ile Asn Arg  
305                 310                 315                 320

Asn Tyr Arg Tyr Glu Leu Met Lys Ala Phe Ile Phe Lys Tyr Ser Ala  
                325                 330                 335    

Lys Thr Gly Leu Thr Lys Leu Ile Asp Ala Ser Arg Val Ser Glu Thr  
            340                 345                 350        

Glu Tyr Ser Ala Leu Glu Gln Ser Thr Lys                          
        355                 360        


<210> 3
<211> 1089
<212> DNA
<213> Homo sapiens

<220> 
<223> human chemokine receptor CXCR7.2

<400> 3
atggatctgc acctcttcga ctacgccgag ccaggcaact tctcggacat cagctggcca 60    
tgcaacagca gcgactgcat cgtggtggac acggtgatgt gtcccaacat gcccaacaaa 120   
agcgtcctgc tctacacgct ctccttcatt tacattttca tcttcgtcat cggcatgatt 180   
gccaactccg tggtggtctg ggtgaatatc caggccaaga ccacaggcta tgacacgcac 240   
tgctacatct tgaacctggc cattgccgac ctgtgggttg tcctcaccat cccagtctgg 300   
gtggtcagtc tcgtgcagca caaccagtgg cccatgggcg agctcacgtg caaagtcaca 360   
cacctcatct tctccatcaa cctcttcagc ggcattttct tcctcacgtg catgagcgtg 420   
gaccgctacc tctccatcac ctacttcacc aacaccccca gcagcaggaa gaagatggta 480   
cgccgtgtcg tctgcatcct ggtgtggctg ctggccttct gcgtgtctct gcctgacacc 540   
tactacctga agaccgtcac gtctgcgtcc aacaatgaga cctactgccg gtccttctac 600   
cccgagcaca gcatcaagga gtggctgatc ggcatggagc tggtctccgt tgtcttgggc 660   
tttgccgttc ccttctccat tatcgctgtc ttctacttcc tgctggccag agccatctcg 720   
gcgtccagtg accaggagaa gcacagcagc cggaagatca tcttctccta cgtggtggtc 780   
ttccttgtct gctggctgcc ctaccacgtg gcggtgctgc tggacatctt ctccatcctg 840   
cactacatcc ctttcacctg ccggctggag cacgccctct tcacggccct gcatgtcaca 900   
cagtgcctgt cgctggtgca ctgctgcgtc aaccctgtcc tctacagctt catcaatcgc 960   
aactacaggt acgagctgat gaaggccttc atcttcaagt actcggccaa aacagggctc 1020  
accaagctca tcgatgcctc cagagtgtcg gagacggagt actccgcctt ggagcaaaac 1080  
gccaagtga                                                         1089  


<210> 4
<211> 362
<212> PRT
<213> Homo sapiens

<220> 
<223> human chemokine receptor CXCR7.2

<400> 4
Met Asp Leu His Leu Phe Asp Tyr Ala Glu Pro Gly Asn Phe Ser Asp  
  1               5                  10                  15    

Ile Ser Trp Pro Cys Asn Ser Ser Asp Cys Ile Val Val Asp Thr Val  
             20                  25                  30        

Met Cys Pro Asn Met Pro Asn Lys Ser Val Leu Leu Tyr Thr Leu Ser  
         35                  40                  45            

Phe Ile Tyr Ile Phe Ile Phe Val Ile Gly Met Ile Ala Asn Ser Val  
     50                  55                  60                

Val Val Trp Val Asn Ile Gln Ala Lys Thr Thr Gly Tyr Asp Thr His  
 65                  70                  75                  80

Cys Tyr Ile Leu Asn Leu Ala Ile Ala Asp Leu Trp Val Val Leu Thr  
                 85                  90                  95    

Ile Pro Val Trp Val Val Ser Leu Val Gln His Asn Gln Trp Pro Met  
            100                 105                 110        

Gly Glu Leu Thr Cys Lys Val Thr His Leu Ile Phe Ser Ile Asn Leu  
        115                 120                 125            

Phe Ser Gly Ile Phe Phe Leu Thr Cys Met Ser Val Asp Arg Tyr Leu  
    130                 135                 140                

Ser Ile Thr Tyr Phe Thr Asn Thr Pro Ser Ser Arg Lys Lys Met Val  
145                 150                 155                 160

Arg Arg Val Val Cys Ile Leu Val Trp Leu Leu Ala Phe Cys Val Ser  
                165                 170                 175    

Leu Pro Asp Thr Tyr Tyr Leu Lys Thr Val Thr Ser Ala Ser Asn Asn  
            180                 185                 190        

Glu Thr Tyr Cys Arg Ser Phe Tyr Pro Glu His Ser Ile Lys Glu Trp  
        195                 200                 205            

Leu Ile Gly Met Glu Leu Val Ser Val Val Leu Gly Phe Ala Val Pro  
    210                 215                 220                

Phe Ser Ile Ile Ala Val Phe Tyr Phe Leu Leu Ala Arg Ala Ile Ser  
225                 230                 235                 240

Ala Ser Ser Asp Gln Glu Lys His Ser Ser Arg Lys Ile Ile Phe Ser  
                245                 250                 255    

Tyr Val Val Val Phe Leu Val Cys Trp Leu Pro Tyr His Val Ala Val  
            260                 265                 270        

Leu Leu Asp Ile Phe Ser Ile Leu His Tyr Ile Pro Phe Thr Cys Arg  
        275                 280                 285            

Leu Glu His Ala Leu Phe Thr Ala Leu His Val Thr Gln Cys Leu Ser  
    290                 295                 300                

Leu Val His Cys Cys Val Asn Pro Val Leu Tyr Ser Phe Ile Asn Arg  
305                 310                 315                 320

Asn Tyr Arg Tyr Glu Leu Met Lys Ala Phe Ile Phe Lys Tyr Ser Ala  
                325                 330                 335    

Lys Thr Gly Leu Thr Lys Leu Ile Asp Ala Ser Arg Val Ser Glu Thr  
            340                 345                 350        

Glu Tyr Ser Ala Leu Glu Gln Asn Ala Lys                          
        355                 360        


<210> 5
<211> 1089
<212> DNA
<213> Homo sapiens

<220> 
<223> human chemokine receptor CXCR7.3

<400> 5
atggatctgc atctcttcga ctactcagag ccagggaact tctcggacat cagctggcca 60    
tgcaacagca gcgactgcat cgtggtggac acggtgatgt gtcccaacat gcccaacaaa 120   
agcgtcctgc tctacacgct ctccttcatt tacattttca tcttcgtcat cggcatgatt 180   
gccaactccg tggtggtctg ggtgaatatc caggccaaga ccacaggcta tgacacgcac 240   
tgctacatct tgaacctggc cattgccgac ctgtgggttg tcctcaccat cccagtctgg 300   
gtggtcagtc tcgtgcagca caaccagtgg cccatgggcg agctcacgtg caaagtcaca 360   
cacctcatct tctccatcaa cctcttcggc agcattttct tcctcacgtg catgagcgtg 420   
gaccgctacc tctccatcac ctacttcacc aacaccccca gcagcaggaa gaagatggta 480   
cgccgtgtcg tctgcatcct ggtgtggctg ctggccttct gcgtgtctct gcctgacacc 540   
tactacctga agaccgtcac gtctgcgtcc aacaatgaga cctactgccg gtccttctac 600   
cccgagcaca gcatcaagga gtggctgatc ggcatggagc tggtctccgt tgtcttgggc 660   
tttgccgttc ccttctccat tgtcgctgtc ttctacttcc tgctggccag agccatctcg 720   
gcgtccagtg accaggagaa gcacagcagc cggaagatca tcttctccta cgtggtggtc 780   
ttccttgtct gctggttgcc ctaccacgtg gcggtgctgc tggacatctt ctccatcctg 840   
cactacatcc ctttcacctg ccggctggag cacgccctct tcacggccct gcatgtcaca 900   
cagtgcctgt cgctggtgca ctgctgcgtc aaccctgtcc tctacagctt catcaatcgc 960   
aactacaggt acgagctgat gaaggccttc atcttcaagt actcggccaa aacagggctc 1020  
accaagctca tcgatgcctc cagagtctca gagacggagt actctgcctt ggagcagagc 1080  
accaaatga                                                         1089  


<210> 6
<211> 362
<212> PRT
<213> Homo sapiens

<220> 
<223> human chemokine receptor CXCR7.3

<400> 6
Met Asp Leu His Leu Phe Asp Tyr Ser Glu Pro Gly Asn Phe Ser Asp  
  1               5                  10                  15    

Ile Ser Trp Pro Cys Asn Ser Ser Asp Cys Ile Val Val Asp Thr Val  
             20                  25                  30        

Met Cys Pro Asn Met Pro Asn Lys Ser Val Leu Leu Tyr Thr Leu Ser  
         35                  40                  45            

Phe Ile Tyr Ile Phe Ile Phe Val Ile Gly Met Ile Ala Asn Ser Val  
     50                  55                  60                

Val Val Trp Val Asn Ile Gln Ala Lys Thr Thr Gly Tyr Asp Thr His  
 65                  70                  75                  80

Cys Tyr Ile Leu Asn Leu Ala Ile Ala Asp Leu Trp Val Val Leu Thr  
                 85                  90                  95    

Ile Pro Val Trp Val Val Ser Leu Val Gln His Asn Gln Trp Pro Met  
            100                 105                 110        

Gly Glu Leu Thr Cys Lys Val Thr His Leu Ile Phe Ser Ile Asn Leu  
        115                 120                 125            

Phe Gly Ser Ile Phe Phe Leu Thr Cys Met Ser Val Asp Arg Tyr Leu  
    130                 135                 140                

Ser Ile Thr Tyr Phe Thr Asn Thr Pro Ser Ser Arg Lys Lys Met Val  
145                 150                 155                 160

Arg Arg Val Val Cys Ile Leu Val Trp Leu Leu Ala Phe Cys Val Ser  
                165                 170                 175    

Leu Pro Asp Thr Tyr Tyr Leu Lys Thr Val Thr Ser Ala Ser Asn Asn  
            180                 185                 190        

Glu Thr Tyr Cys Arg Ser Phe Tyr Pro Glu His Ser Ile Lys Glu Trp  
        195                 200                 205            

Leu Ile Gly Met Glu Leu Val Ser Val Val Leu Gly Phe Ala Val Pro  
    210                 215                 220                

Phe Ser Ile Val Ala Val Phe Tyr Phe Leu Leu Ala Arg Ala Ile Ser  
225                 230                 235                 240

Ala Ser Ser Asp Gln Glu Lys His Ser Ser Arg Lys Ile Ile Phe Ser  
                245                 250                 255    

Tyr Val Val Val Phe Leu Val Cys Trp Leu Pro Tyr His Val Ala Val  
            260                 265                 270        

Leu Leu Asp Ile Phe Ser Ile Leu His Tyr Ile Pro Phe Thr Cys Arg  
        275                 280                 285            

Leu Glu His Ala Leu Phe Thr Ala Leu His Val Thr Gln Cys Leu Ser  
    290                 295                 300                

Leu Val His Cys Cys Val Asn Pro Val Leu Tyr Ser Phe Ile Asn Arg  
305                 310                 315                 320

Asn Tyr Arg Tyr Glu Leu Met Lys Ala Phe Ile Phe Lys Tyr Ser Ala  
                325                 330                 335    

Lys Thr Gly Leu Thr Lys Leu Ile Asp Ala Ser Arg Val Ser Glu Thr  
            340                 345                 350        

Glu Tyr Ser Ala Leu Glu Gln Ser Thr Lys                          
        355                 360        


<210> 7
<211> 1089
<212> DNA
<213> Homo sapiens

<220> 
<223> human chemokine receptor CXCR7.4

<400> 7
atggatctgc atctcttcga ctactcagag ccagggaact tctcggacat cagctggcca 60    
tgcaacagca gcgactgcat cgtggtggac acggtgatgt gtcccaacat gcccaacaaa 120   
agcgtcctgc tctacacgct ctccttcatt tacattttca tcttcgtcat cggcatgatt 180   
gccaactccg tggtggtctg ggtgaatatc caggccaaga ccacaggcta tgacacgcac 240   
tgctacatct tgaacctggc cattgccgac ctgtgggttg tcctcaccat cccagtctgg 300   
gtggtcagtc tcgtgcagca caaccagtgg cccatgggcg agctcacgtg caaagtcaca 360   
cacctcatct tctccatcaa cctcttcggc agcattttct tcctcacgtg catgagcgtg 420   
gaccgctacc tctccatcac ctacttcacc aacaccccca gcagcaggaa gaagatggta 480   
cgccgtgtcg tctgcatcct ggtgtggctg ctggccttct gcgtgtctct gcctgacacc 540   
tactacctga agaccgtcac gtctgcgtcc aacaatgaga cctactgccg gtccttctac 600   
cccgagcaca gcatcaagga gtggctgatc ggcatggagc tggtctccgt tgtcttgggc 660   
tttgccgttc ccttctccat tatcgctgtc ttctacttcc tgctggccag agccatctcg 720   
gcgtccagtg accaggagaa gcacagcagc cggaagatca tcttctccta cgtggtggtc 780   
ttccttgtct gctggctgcc ctaccacgtg gcggtgctgc tggacatctt ctccatcctg 840   
cactacatcc ctttcacctg ccggctggag cacgccctct tcacggccct gcatgtcaca 900   
cagtgcctgt cgctggtgca ctgctgcgtc aaccctgtcc tctacagctt catcaatcgc 960   
aactacaggt acgagctgat gaaggccttc atcttcaagt actcggccaa aacagggctc 1020  
accaagctca tcgatgcctc cagagtctca gagacggagt actctgcctt ggagcagagc 1080  
accaaatga                                                         1089  


<210> 8
<211> 362
<212> PRT
<213> Homo sapiens

<220> 
<223> human chemokine receptor CXCR7.4

<400> 8
Met Asp Leu His Leu Phe Asp Tyr Ser Glu Pro Gly Asn Phe Ser Asp  
  1               5                  10                  15    

Ile Ser Trp Pro Cys Asn Ser Ser Asp Cys Ile Val Val Asp Thr Val  
             20                  25                  30        

Met Cys Pro Asn Met Pro Asn Lys Ser Val Leu Leu Tyr Thr Leu Ser  
         35                  40                  45            

Phe Ile Tyr Ile Phe Ile Phe Val Ile Gly Met Ile Ala Asn Ser Val  
     50                  55                  60                

Val Val Trp Val Asn Ile Gln Ala Lys Thr Thr Gly Tyr Asp Thr His  
 65                  70                  75                  80

Cys Tyr Ile Leu Asn Leu Ala Ile Ala Asp Leu Trp Val Val Leu Thr  
                 85                  90                  95    

Ile Pro Val Trp Val Val Ser Leu Val Gln His Asn Gln Trp Pro Met  
            100                 105                 110        

Gly Glu Leu Thr Cys Lys Val Thr His Leu Ile Phe Ser Ile Asn Leu  
        115                 120                 125            

Phe Gly Ser Ile Phe Phe Leu Thr Cys Met Ser Val Asp Arg Tyr Leu  
    130                 135                 140                

Ser Ile Thr Tyr Phe Thr Asn Thr Pro Ser Ser Arg Lys Lys Met Val  
145                 150                 155                 160

Arg Arg Val Val Cys Ile Leu Val Trp Leu Leu Ala Phe Cys Val Ser  
                165                 170                 175    

Leu Pro Asp Thr Tyr Tyr Leu Lys Thr Val Thr Ser Ala Ser Asn Asn  
            180                 185                 190        

Glu Thr Tyr Cys Arg Ser Phe Tyr Pro Glu His Ser Ile Lys Glu Trp  
        195                 200                 205            

Leu Ile Gly Met Glu Leu Val Ser Val Val Leu Gly Phe Ala Val Pro  
    210                 215                 220                

Phe Ser Ile Ile Ala Val Phe Tyr Phe Leu Leu Ala Arg Ala Ile Ser  
225                 230                 235                 240

Ala Ser Ser Asp Gln Glu Lys His Ser Ser Arg Lys Ile Ile Phe Ser  
                245                 250                 255    

Tyr Val Val Val Phe Leu Val Cys Trp Leu Pro Tyr His Val Ala Val  
            260                 265                 270        

Leu Leu Asp Ile Phe Ser Ile Leu His Tyr Ile Pro Phe Thr Cys Arg  
        275                 280                 285            

Leu Glu His Ala Leu Phe Thr Ala Leu His Val Thr Gln Cys Leu Ser  
    290                 295                 300                

Leu Val His Cys Cys Val Asn Pro Val Leu Tyr Ser Phe Ile Asn Arg  
305                 310                 315                 320

Asn Tyr Arg Tyr Glu Leu Met Lys Ala Phe Ile Phe Lys Tyr Ser Ala  
                325                 330                 335    

Lys Thr Gly Leu Thr Lys Leu Ile Asp Ala Ser Arg Val Ser Glu Thr  
            340                 345                 350        

Glu Tyr Ser Ala Leu Glu Gln Ser Thr Lys                          
        355                 360        


<210> 9
<211> 1089
<212> DNA
<213> Homo sapiens

<220> 
<223> human chemokine receptor CXCR7.5

<400> 9
atggatctgc atctcttcga ctactcagag ccagggaact tctcggacat cagctggccg 60    
tgcaacagca gcgactgcat cgtggtggac acggtgatgt gtcccaacat gcccaacaaa 120   
agcgtcctgc tctacacgct ctccttcatt tacattttca tcttcgtcat cggcatgatt 180   
gccaactccg tggtggtctg ggtgaatatc caggccaaga ccacaggcta tgacacgcac 240   
tgctacatct tgaacctggc cattgccgac ctgtgggttg tcctcaccat cccagtctgg 300   
gtggtcagtc tcgtgcagca caaccagtgg cccatgggcg agctcacgtg caaagtcaca 360   
cacctcatct tctccatcaa cctcttcagc agcattttct tcctcacgtg catgagcgtg 420   
gaccgctacc tctccatcac ctacttcacc aacaccccca gcagcaggaa gaagatggta 480   
cgccgtgtcg tctgcatcct ggtgtggctg ctggccttct gcgtgtctct gcctgacacc 540   
tactacctga agaccgtcac gtctgcgtcc aacaatgaga cctactgccg gtccttctac 600   
cccgagcaca gcatcaagga gtggctgatc ggcatggagc tggtctccgt tgtcttgggc 660   
tttgccgttc ccttctccat tatcgctgtc ttctacttcc tgctggccag agccatctcg 720   
gcgtccagtg accaggagaa gcacagcagc cggaagatca tcttctccta cgtggtggtc 780   
ttccttgtct gctggttgcc ctaccacgtg gcggtgctgc tggacatctt ctccatcctg 840   
cactacatcc ctttcacctg ccggctggag cacgccctct tcacggccct gcatgtcaca 900   
cagtgcctgt cgctggtgca ctgctgcgtc aaccctgtcc tctacagctt catcaatcgc 960   
aactacaggt acgagctgat gaaggccttc atcttcaagt actcggccaa aacagggctc 1020  
accaagctca tcgatgcctc cagagtctca gagacggagt actccgcctt ggagcagagc 1080  
accaaatga                                                         1089  


<210> 10
<211> 362
<212> PRT
<213> Homo sapiens

<220> 
<223> human chemokine receptor CXCR7.5

<400> 10
Met Asp Leu His Leu Phe Asp Tyr Ser Glu Pro Gly Asn Phe Ser Asp  
  1               5                  10                  15    

Ile Ser Trp Pro Cys Asn Ser Ser Asp Cys Ile Val Val Asp Thr Val  
             20                  25                  30        

Met Cys Pro Asn Met Pro Asn Lys Ser Val Leu Leu Tyr Thr Leu Ser  
         35                  40                  45            

Phe Ile Tyr Ile Phe Ile Phe Val Ile Gly Met Ile Ala Asn Ser Val  
     50                  55                  60                

Val Val Trp Val Asn Ile Gln Ala Lys Thr Thr Gly Tyr Asp Thr His  
 65                  70                  75                  80

Cys Tyr Ile Leu Asn Leu Ala Ile Ala Asp Leu Trp Val Val Leu Thr  
                 85                  90                  95    

Ile Pro Val Trp Val Val Ser Leu Val Gln His Asn Gln Trp Pro Met  
            100                 105                 110        

Gly Glu Leu Thr Cys Lys Val Thr His Leu Ile Phe Ser Ile Asn Leu  
        115                 120                 125            

Phe Ser Ser Ile Phe Phe Leu Thr Cys Met Ser Val Asp Arg Tyr Leu  
    130                 135                 140                

Ser Ile Thr Tyr Phe Thr Asn Thr Pro Ser Ser Arg Lys Lys Met Val  
145                 150                 155                 160

Arg Arg Val Val Cys Ile Leu Val Trp Leu Leu Ala Phe Cys Val Ser  
                165                 170                 175    

Leu Pro Asp Thr Tyr Tyr Leu Lys Thr Val Thr Ser Ala Ser Asn Asn  
            180                 185                 190        

Glu Thr Tyr Cys Arg Ser Phe Tyr Pro Glu His Ser Ile Lys Glu Trp  
        195                 200                 205            

Leu Ile Gly Met Glu Leu Val Ser Val Val Leu Gly Phe Ala Val Pro  
    210                 215                 220                

Phe Ser Ile Ile Ala Val Phe Tyr Phe Leu Leu Ala Arg Ala Ile Ser  
225                 230                 235                 240

Ala Ser Ser Asp Gln Glu Lys His Ser Ser Arg Lys Ile Ile Phe Ser  
                245                 250                 255    

Tyr Val Val Val Phe Leu Val Cys Trp Leu Pro Tyr His Val Ala Val  
            260                 265                 270        

Leu Leu Asp Ile Phe Ser Ile Leu His Tyr Ile Pro Phe Thr Cys Arg  
        275                 280                 285            

Leu Glu His Ala Leu Phe Thr Ala Leu His Val Thr Gln Cys Leu Ser  
    290                 295                 300                

Leu Val His Cys Cys Val Asn Pro Val Leu Tyr Ser Phe Ile Asn Arg  
305                 310                 315                 320

Asn Tyr Arg Tyr Glu Leu Met Lys Ala Phe Ile Phe Lys Tyr Ser Ala  
                325                 330                 335    

Lys Thr Gly Leu Thr Lys Leu Ile Asp Ala Ser Arg Val Ser Glu Thr  
            340                 345                 350        

Glu Tyr Ser Ala Leu Glu Gln Ser Thr Lys                          
        355                 360        


<210> 11
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:synthetic PCR
      primer hRDC1F

<400> 11
gaatgcggcc gctatggatc tgcatctctt cgact                            35    


<210> 12
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:synthetic PCR
      primer hRDC1R

<400> 12
gaatgcggcc gctcatttgg tgctctgctc caag                             34    


