
                                SEQUENCE LISTING

<110> The Regents of the University of California
      FONG, LAWRENCE H.
      MacPhee, Serena Kwek

<120> Disease-Associated Antigens and Methods
  of Use Thereof

<130> UCSF-405WO

<150> US 61/109,428       
<151> 2008-10-29  

<160> 155

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 352
<212> PRT
<213> Homo sapiens

<400> 1
Met Ala Pro Lys Leu Ile Thr Val Leu Cys Leu Gly Phe Cys Leu Asn
 1               5                  10                  15      
Gln Lys Ile Cys Pro His Ala Gly Ala Gln Asp Lys Phe Ser Leu Ser
            20                  25                  30          
Ala Trp Pro Ser Pro Val Val Pro Leu Gly Gly Arg Val Thr Leu Ser
        35                  40                  45              
Cys His Ser His Leu Arg Phe Val Ile Trp Thr Ile Phe Gln Thr Thr
    50                  55                  60                  
Gly Thr Arg Ser His Glu Leu His Thr Gly Leu Ser Asn Asn Ile Thr
65                  70                  75                  80  
Ile Ser Pro Val Thr Pro Glu His Ala Gly Thr Tyr Arg Cys Val Gly
                85                  90                  95      
Ile Tyr Lys His Ala Ser Lys Trp Ser Ala Glu Ser Asn Ser Leu Lys
            100                 105                 110         
Ile Ile Val Thr Gly Leu Phe Thr Lys Pro Ser Ile Ser Ala His Pro
        115                 120                 125             
Ser Ser Leu Val His Ala Gly Ala Arg Val Ser Leu Arg Cys His Ser
    130                 135                 140                 
Glu Leu Ala Phe Asp Glu Phe Ile Leu Tyr Lys Glu Gly His Ile Gln
145                 150                 155                 160 
His Ser Gln Gln Leu Asp Gln Gly Met Glu Ala Gly Ile His Tyr Val
                165                 170                 175     
Glu Ala Val Phe Ser Met Gly Pro Val Thr Pro Ala His Ala Gly Ala
            180                 185                 190         
Tyr Arg Cys Cys Gly Cys Phe Ser His Ser Arg Tyr Glu Trp Ser Ala
        195                 200                 205             
Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Lys Tyr Lys Lys Pro
    210                 215                 220                 
Ser Leu Ser Thr Gln Val Asp Pro Met Met Arg Leu Gly Glu Lys Leu
225                 230                 235                 240 
Thr Leu Phe Cys Ser Ser Glu Ile Ser Phe Asp Gln Tyr His Leu Phe
                245                 250                 255     
Arg His Gly Val Ala His Gly Gln Trp Leu Ser Gly Gly Gln Arg His
            260                 265                 270         
Arg Glu Ala Phe Gln Ala Asn Phe Ser Val Gly Arg Ala Thr Pro Val
        275                 280                 285             
Pro Gly Gly Thr Tyr Arg Cys Tyr Gly Ser Phe Asn Asp Ser Pro Tyr
    290                 295                 300                 
Lys Pro Pro Val Thr Arg Cys Asn Phe Thr Pro Gln Glu Thr Leu Arg
305                 310                 315                 320 
Val Leu Leu Cys His Ser Gln Asn Pro Pro Leu Asn Leu Thr His Leu
                325                 330                 335     
Ala Leu Lys Asp Ser Pro Ala Thr Cys Ile Cys Ser Leu Asp Ser Gln
            340                 345                 350         


<210> 2
<211> 344
<212> PRT
<213> Homo sapiens

<400> 2
Met Ala Gln Lys Glu Asn Ser Tyr Pro Trp Pro Tyr Gly Arg Gln Thr
 1               5                  10                  15      
Ala Pro Ser Gly Leu Ser Thr Leu Pro Gln Arg Val Leu Arg Lys Glu
            20                  25                  30          
Pro Val Thr Pro Ser Ala Leu Val Leu Met Ser Arg Ser Asn Val Gln
        35                  40                  45              
Pro Thr Ala Ala Pro Gly Gln Lys Val Met Glu Asn Ser Ser Gly Thr
    50                  55                  60                  
Pro Asp Ile Leu Thr Arg His Phe Thr Ile Asp Asp Phe Glu Ile Gly
65                  70                  75                  80  
Arg Pro Leu Gly Lys Gly Lys Phe Gly Asn Val Tyr Leu Ala Arg Glu
                85                  90                  95      
Lys Lys Ser His Phe Ile Val Ala Leu Lys Val Leu Phe Lys Ser Gln
            100                 105                 110         
Ile Glu Lys Glu Gly Val Glu His Gln Leu Arg Arg Glu Ile Glu Ile
        115                 120                 125             
Gln Ala His Leu His His Pro Asn Ile Leu Arg Leu Tyr Asn Tyr Phe
    130                 135                 140                 
Tyr Asp Arg Arg Arg Ile Tyr Leu Ile Leu Glu Tyr Ala Pro Arg Gly
145                 150                 155                 160 
Glu Leu Tyr Lys Glu Leu Gln Lys Ser Cys Thr Phe Asp Glu Gln Arg
                165                 170                 175     
Thr Ala Thr Ile Met Glu Glu Leu Ala Asp Ala Leu Met Tyr Cys His
            180                 185                 190         
Gly Lys Lys Val Ile His Arg Asp Ile Lys Pro Glu Asn Leu Leu Leu
        195                 200                 205             
Gly Leu Lys Gly Glu Leu Lys Ile Ala Asp Phe Gly Trp Ser Val His
    210                 215                 220                 
Ala Pro Ser Leu Arg Arg Lys Thr Met Cys Gly Thr Leu Asp Tyr Leu
225                 230                 235                 240 
Pro Pro Glu Met Ile Glu Gly Arg Met His Asn Glu Lys Val Asp Leu
                245                 250                 255     
Trp Cys Ile Gly Val Leu Cys Tyr Glu Leu Leu Val Gly Asn Pro Pro
            260                 265                 270         
Phe Glu Ser Ala Ser His Asn Glu Thr Tyr Arg Arg Ile Val Lys Val
        275                 280                 285             
Asp Leu Lys Phe Pro Ala Ser Val Pro Met Gly Ala Gln Asp Leu Ile
    290                 295                 300                 
Ser Lys Leu Leu Arg His Asn Pro Ser Glu Arg Leu Pro Leu Ala Gln
305                 310                 315                 320 
Val Ser Ala His Pro Trp Val Arg Ala Asn Ser Arg Arg Val Leu Pro
                325                 330                 335     
Pro Ser Ala Leu Gln Ser Val Ala
            340                 


<210> 3
<211> 646
<212> PRT
<213> Homo sapiens

<400> 3
Met Glu Pro Ala Ala Gly Phe Leu Ser Pro Arg Pro Phe Gln Arg Ala
 1               5                  10                  15      
Ala Ala Ala Pro Ala Pro Pro Ala Gly Pro Gly Pro Pro Pro Ser Ala
            20                  25                  30          
Leu Arg Gly Pro Glu Leu Glu Met Leu Ala Gly Leu Pro Thr Ser Asp
        35                  40                  45              
Pro Gly Arg Leu Ile Thr Asp Pro Arg Ser Gly Arg Thr Tyr Leu Lys
    50                  55                  60                  
Gly Arg Leu Leu Gly Lys Gly Gly Phe Ala Arg Cys Tyr Glu Ala Thr
65                  70                  75                  80  
Asp Thr Glu Thr Gly Ser Ala Tyr Ala Val Lys Val Ile Pro Gln Ser
                85                  90                  95      
Arg Val Ala Lys Pro His Gln Arg Glu Lys Ile Leu Asn Glu Ile Glu
            100                 105                 110         
Leu His Arg Asp Leu Gln His Arg His Ile Val Arg Phe Ser His His
        115                 120                 125             
Phe Glu Asp Ala Asp Asn Ile Tyr Ile Phe Leu Glu Leu Cys Ser Arg
    130                 135                 140                 
Lys Ser Leu Ala His Ile Trp Lys Ala Arg His Thr Leu Leu Glu Pro
145                 150                 155                 160 
Glu Val Arg Tyr Tyr Leu Arg Gln Ile Leu Ser Gly Leu Lys Tyr Leu
                165                 170                 175     
His Gln Arg Gly Ile Leu His Arg Asp Leu Lys Leu Gly Asn Phe Phe
            180                 185                 190         
Ile Thr Glu Asn Met Glu Leu Lys Val Gly Asp Phe Gly Leu Ala Ala
        195                 200                 205             
Arg Leu Glu Pro Pro Glu Gln Arg Lys Lys Thr Ile Cys Gly Thr Pro
    210                 215                 220                 
Asn Tyr Val Ala Pro Glu Val Leu Leu Arg Gln Gly His Gly Pro Glu
225                 230                 235                 240 
Ala Asp Val Trp Ser Leu Gly Cys Val Met Tyr Thr Leu Leu Cys Gly
                245                 250                 255     
Ser Pro Pro Phe Glu Thr Ala Asp Leu Lys Glu Thr Tyr Arg Cys Ile
            260                 265                 270         
Lys Gln Val His Tyr Thr Leu Pro Ala Ser Leu Ser Leu Pro Ala Arg
        275                 280                 285             
Gln Leu Leu Ala Ala Ile Leu Arg Ala Ser Pro Arg Asp Arg Pro Ser
    290                 295                 300                 
Ile Asp Gln Ile Leu Arg His Asp Phe Phe Thr Lys Gly Tyr Thr Pro
305                 310                 315                 320 
Asp Arg Leu Pro Ile Ser Ser Cys Val Thr Val Pro Asp Leu Thr Pro
                325                 330                 335     
Pro Asn Pro Ala Arg Ser Leu Phe Ala Lys Val Thr Lys Ser Leu Phe
            340                 345                 350         
Gly Arg Lys Lys Lys Ser Lys Asn His Ala Gln Glu Arg Asp Glu Val
        355                 360                 365             
Ser Gly Leu Val Ser Gly Leu Met Arg Thr Ser Val Gly His Gln Asp
    370                 375                 380                 
Ala Arg Pro Glu Ala Pro Ala Ala Ser Gly Pro Ala Pro Val Ser Leu
385                 390                 395                 400 
Val Glu Thr Ala Pro Glu Asp Ser Ser Pro Arg Gly Thr Leu Ala Ser
                405                 410                 415     
Ser Gly Asp Gly Phe Glu Glu Gly Leu Thr Val Ala Thr Val Val Glu
            420                 425                 430         
Ser Ala Leu Cys Ala Leu Arg Asn Cys Ile Ala Phe Met Pro Pro Ala
        435                 440                 445             
Glu Gln Asn Pro Ala Pro Leu Ala Gln Pro Glu Pro Leu Val Trp Val
    450                 455                 460                 
Ser Lys Trp Val Asp Tyr Ser Asn Lys Phe Gly Phe Gly Tyr Gln Leu
465                 470                 475                 480 
Ser Ser Arg Arg Val Ala Val Leu Phe Asn Asp Gly Thr His Met Ala
                485                 490                 495     
Leu Ser Ala Asn Arg Lys Thr Val His Tyr Asn Pro Thr Ser Thr Lys
            500                 505                 510         
His Phe Ser Phe Ser Val Gly Ala Val Pro Arg Ala Leu Gln Pro Gln
        515                 520                 525             
Leu Gly Ile Leu Arg Tyr Phe Ala Ser Tyr Met Glu Gln His Leu Met
    530                 535                 540                 
Lys Gly Gly Asp Leu Pro Ser Val Glu Glu Val Glu Val Pro Ala Pro
545                 550                 555                 560 
Pro Leu Leu Leu Gln Trp Val Lys Thr Asp Gln Ala Leu Leu Met Leu
                565                 570                 575     
Phe Ser Asp Gly Thr Val Gln Val Asn Phe Tyr Gly Asp His Thr Lys
            580                 585                 590         
Leu Ile Leu Ser Gly Trp Glu Pro Leu Leu Val Thr Phe Val Ala Arg
        595                 600                 605             
Asn Arg Ser Ala Cys Thr Tyr Leu Ala Ser His Leu Arg Gln Leu Gly
    610                 615                 620                 
Cys Ser Pro Asp Leu Arg Gln Arg Leu Arg Tyr Ala Leu Arg Leu Leu
625                 630                 635                 640 
Arg Asp Arg Ser Pro Ala
                645     


<210> 4
<211> 293
<212> PRT
<213> Homo sapiens

<400> 4
Met Pro Ala Arg Ser Gly Ala Gln Phe Cys Arg Arg Met Gly Gln Lys
 1               5                  10                  15      
Lys Gln Arg Pro Ala Arg Ala Gly Gln Pro His Ser Ser Ser Asp Ala
            20                  25                  30          
Ala Gln Ala Pro Ala Glu Gln Pro His Ser Ser Ser Asp Ala Ala Gln
        35                  40                  45              
Ala Pro Cys Pro Arg Glu Arg Cys Leu Gly Pro Pro Thr Thr Pro Gly
    50                  55                  60                  
Pro Tyr Arg Ser Ile Tyr Phe Ser Ser Pro Lys Gly His Leu Thr Arg
65                  70                  75                  80  
Leu Gly Leu Glu Phe Phe Asp Gln Pro Ala Val Pro Leu Ala Arg Ala
                85                  90                  95      
Phe Leu Gly Gln Val Leu Val Arg Arg Leu Pro Asn Gly Thr Glu Leu
            100                 105                 110         
Arg Gly Arg Ile Val Glu Thr Glu Ala Tyr Leu Gly Pro Glu Asp Glu
        115                 120                 125             
Ala Ala His Ser Arg Gly Gly Arg Gln Thr Pro Arg Asn Arg Gly Met
    130                 135                 140                 
Phe Met Lys Pro Gly Thr Leu Tyr Val Tyr Ile Ile Tyr Gly Met Tyr
145                 150                 155                 160 
Phe Cys Met Asn Ile Ser Ser Gln Gly Asp Gly Ala Cys Val Leu Leu
                165                 170                 175     
Arg Ala Leu Glu Pro Leu Glu Gly Leu Glu Thr Met Arg Gln Leu Arg
            180                 185                 190         
Ser Thr Leu Arg Lys Gly Thr Ala Ser Arg Val Leu Lys Asp Arg Glu
        195                 200                 205             
Leu Cys Ser Gly Pro Ser Lys Leu Cys Gln Ala Leu Ala Ile Asn Lys
    210                 215                 220                 
Ser Phe Asp Gln Arg Asp Leu Ala Gln Asp Glu Ala Val Trp Leu Glu
225                 230                 235                 240 
Arg Gly Pro Leu Glu Pro Ser Glu Pro Ala Val Val Ala Ala Ala Arg
                245                 250                 255     
Val Gly Val Gly His Ala Gly Glu Trp Ala Arg Lys Pro Leu Arg Phe
            260                 265                 270         
Tyr Val Arg Gly Ser Pro Trp Val Ser Val Val Asp Arg Val Ala Glu
        275                 280                 285             
Gln Asp Thr Gln Ala
    290             


<210> 5
<211> 445
<212> PRT
<213> Homo sapiens

<400> 5
Met Pro Ser Arg Ala Glu Asp Tyr Glu Val Leu Tyr Thr Ile Gly Thr
 1               5                  10                  15      
Gly Ser Tyr Gly Arg Cys Gln Lys Ile Arg Arg Lys Ser Asp Gly Lys
            20                  25                  30          
Ile Leu Val Trp Lys Glu Leu Asp Tyr Gly Ser Met Thr Glu Ala Glu
        35                  40                  45              
Lys Gln Met Leu Val Ser Glu Val Asn Leu Leu Arg Glu Leu Lys His
    50                  55                  60                  
Pro Asn Ile Val Arg Tyr Tyr Asp Arg Ile Ile Asp Arg Thr Asn Thr
65                  70                  75                  80  
Thr Leu Tyr Ile Val Met Glu Tyr Cys Glu Gly Gly Asp Leu Ala Ser
                85                  90                  95      
Val Ile Thr Lys Gly Thr Lys Glu Arg Gln Tyr Leu Asp Glu Glu Phe
            100                 105                 110         
Val Leu Arg Val Met Thr Gln Leu Thr Leu Ala Leu Lys Glu Cys His
        115                 120                 125             
Arg Arg Ser Asp Gly Gly His Thr Val Leu His Arg Asp Leu Lys Pro
    130                 135                 140                 
Ala Asn Val Phe Leu Asp Gly Lys Gln Asn Val Lys Leu Gly Asp Phe
145                 150                 155                 160 
Gly Leu Ala Arg Ile Leu Asn His Asp Thr Ser Phe Ala Lys Thr Phe
                165                 170                 175     
Val Gly Thr Pro Tyr Tyr Met Ser Pro Glu Gln Met Asn Arg Met Ser
            180                 185                 190         
Tyr Asn Glu Lys Ser Asp Ile Trp Ser Leu Gly Cys Leu Leu Tyr Glu
        195                 200                 205             
Leu Cys Ala Leu Met Pro Pro Phe Thr Ala Phe Ser Gln Lys Glu Leu
    210                 215                 220                 
Ala Gly Lys Ile Arg Glu Gly Lys Phe Arg Arg Ile Pro Tyr Arg Tyr
225                 230                 235                 240 
Ser Asp Glu Leu Asn Glu Ile Ile Thr Arg Met Leu Asn Leu Lys Asp
                245                 250                 255     
Tyr His Arg Pro Ser Val Glu Glu Ile Leu Glu Asn Pro Leu Ile Ala
            260                 265                 270         
Asp Leu Val Ala Asp Glu Gln Arg Arg Asn Leu Glu Arg Arg Gly Arg
        275                 280                 285             
Gln Leu Gly Glu Pro Glu Lys Ser Gln Asp Ser Ser Pro Val Leu Ser
    290                 295                 300                 
Glu Leu Lys Leu Lys Glu Ile Gln Leu Gln Glu Arg Glu Arg Ala Leu
305                 310                 315                 320 
Lys Ala Arg Glu Glu Arg Leu Glu Gln Lys Glu Gln Glu Leu Cys Val
                325                 330                 335     
Arg Glu Arg Leu Ala Glu Asp Lys Leu Ala Arg Ala Glu Asn Leu Leu
            340                 345                 350         
Lys Asn Tyr Ser Leu Leu Lys Glu Arg Lys Phe Leu Ser Leu Ala Ser
        355                 360                 365             
Asn Pro Glu Leu Leu Asn Leu Pro Ser Ser Val Ile Lys Lys Lys Val
    370                 375                 380                 
His Phe Ser Gly Glu Ser Lys Glu Asn Ile Met Arg Ser Glu Asn Ser
385                 390                 395                 400 
Glu Ser Gln Leu Thr Ser Lys Ser Lys Cys Lys Asp Leu Lys Lys Arg
                405                 410                 415     
Leu His Ala Ala Gln Leu Arg Ala Gln Ala Leu Ser Asp Ile Glu Lys
            420                 425                 430         
Asn Tyr Gln Leu Lys Ser Arg Gln Ile Leu Gly Met Arg
        435                 440                 445 


<210> 6
<211> 71
<212> PRT
<213> Homo sapiens

<400> 6
Met Glu Arg Ala Arg Asp Arg Leu His Leu Arg Arg Thr Thr Glu Gln
 1               5                  10                  15      
His Val Pro Glu Val Glu Val Gln Val Lys Arg Arg Arg Thr Ala Ser
            20                  25                  30          
Leu Ser Asn Gln Glu Cys Gln Leu Tyr Pro Arg Arg Ser Gln Gln Gln
        35                  40                  45              
Gln Val Pro Val Val Asp Phe Gln Ala Glu Leu Arg Gln Ala Phe Leu
    50                  55                  60                  
Ala Glu Thr Pro Arg Gly Gly
65                  70      


<210> 7
<211> 1101
<212> PRT
<213> Homo sapiens

<400> 7
Met Ser Ala Lys Ala Ile Ser Glu Gln Thr Gly Lys Glu Leu Leu Tyr
 1               5                  10                  15      
Lys Phe Ile Cys Thr Thr Ser Ala Ile Gln Asn Arg Phe Lys Tyr Ala
            20                  25                  30          
Arg Val Thr Pro Asp Thr Asp Trp Ala Arg Leu Leu Gln Asp His Pro
        35                  40                  45              
Trp Leu Leu Ser Gln Asn Leu Val Val Lys Pro Asp Gln Leu Ile Lys
    50                  55                  60                  
Arg Arg Gly Lys Leu Gly Leu Val Gly Val Asn Leu Thr Leu Asp Gly
65                  70                  75                  80  
Val Lys Ser Trp Leu Lys Pro Arg Leu Gly Gln Glu Ala Thr Val Gly
                85                  90                  95      
Lys Ala Thr Gly Phe Leu Lys Asn Phe Leu Ile Glu Pro Phe Val Pro
            100                 105                 110         
His Ser Gln Ala Glu Glu Phe Tyr Val Cys Ile Tyr Ala Thr Arg Glu
        115                 120                 125             
Gly Asp Tyr Val Leu Phe His His Glu Gly Gly Val Asp Val Gly Asp
    130                 135                 140                 
Val Asp Ala Lys Ala Gln Lys Leu Leu Val Gly Val Asp Glu Lys Leu
145                 150                 155                 160 
Asn Pro Glu Asp Ile Lys Lys His Leu Leu Val His Ala Pro Glu Asp
                165                 170                 175     
Lys Lys Glu Ile Leu Ala Ser Phe Ile Ser Gly Leu Phe Asn Phe Tyr
            180                 185                 190         
Glu Asp Leu Tyr Phe Thr Tyr Leu Glu Ile Asn Pro Leu Val Val Thr
        195                 200                 205             
Lys Asp Gly Val Tyr Val Leu Asp Leu Ala Ala Lys Val Asp Ala Thr
    210                 215                 220                 
Ala Asp Tyr Ile Cys Lys Val Lys Trp Gly Asp Ile Glu Phe Pro Pro
225                 230                 235                 240 
Pro Phe Gly Arg Glu Ala Tyr Pro Glu Glu Ala Tyr Ile Ala Asp Leu
                245                 250                 255     
Asp Ala Lys Ser Gly Ala Ser Leu Lys Leu Thr Leu Leu Asn Pro Lys
            260                 265                 270         
Gly Arg Ile Trp Thr Met Val Ala Gly Gly Gly Ala Ser Val Val Tyr
        275                 280                 285             
Ser Asp Thr Ile Cys Asp Leu Gly Gly Val Asn Glu Leu Ala Asn Tyr
    290                 295                 300                 
Gly Glu Tyr Ser Gly Ala Pro Ser Glu Gln Gln Thr Tyr Asp Tyr Ala
305                 310                 315                 320 
Lys Thr Ile Leu Ser Leu Met Thr Arg Glu Lys His Pro Asp Gly Lys
                325                 330                 335     
Ile Leu Ile Ile Gly Gly Ser Ile Ala Asn Phe Thr Asn Val Ala Ala
            340                 345                 350         
Thr Phe Lys Gly Ile Val Arg Ala Ile Arg Asp Tyr Gln Gly Pro Leu
        355                 360                 365             
Lys Glu His Glu Val Thr Ile Phe Val Arg Arg Gly Gly Pro Asn Tyr
    370                 375                 380                 
Gln Glu Gly Leu Arg Val Met Gly Glu Val Gly Lys Thr Thr Gly Ile
385                 390                 395                 400 
Pro Ile His Val Phe Gly Thr Glu Thr His Met Thr Ala Ile Val Gly
                405                 410                 415     
Met Ala Leu Gly His Arg Pro Ile Pro Asn Gln Pro Pro Thr Ala Ala
            420                 425                 430         
His Thr Ala Asn Phe Leu Leu Asn Ala Ser Gly Ser Thr Ser Thr Pro
        435                 440                 445             
Ala Pro Ser Arg Thr Ala Ser Phe Ser Glu Ser Arg Ala Asp Glu Val
    450                 455                 460                 
Ala Pro Ala Lys Lys Ala Lys Pro Ala Met Pro Gln Asp Ser Val Pro
465                 470                 475                 480 
Ser Pro Arg Ser Leu Gln Gly Lys Ser Thr Thr Leu Phe Ser Arg His
                485                 490                 495     
Thr Lys Ala Ile Val Trp Gly Met Gln Thr Arg Ala Val Gln Gly Met
            500                 505                 510         
Leu Asp Phe Asp Tyr Val Cys Ser Arg Asp Glu Pro Ser Val Ala Ala
        515                 520                 525             
Met Val Tyr Pro Phe Thr Gly Asp His Lys Gln Lys Phe Tyr Trp Gly
    530                 535                 540                 
His Lys Glu Ile Leu Ile Pro Val Phe Lys Asn Met Ala Asp Ala Met
545                 550                 555                 560 
Arg Lys His Pro Glu Val Asp Val Leu Ile Asn Phe Ala Ser Leu Arg
                565                 570                 575     
Ser Ala Tyr Asp Ser Thr Met Glu Thr Met Asn Tyr Ala Gln Ile Arg
            580                 585                 590         
Thr Ile Ala Ile Ile Ala Glu Gly Ile Pro Glu Ala Leu Thr Arg Lys
        595                 600                 605             
Leu Ile Lys Lys Ala Asp Gln Lys Gly Val Thr Ile Ile Gly Pro Ala
    610                 615                 620                 
Thr Val Gly Gly Ile Lys Pro Gly Cys Phe Lys Ile Gly Asn Thr Gly
625                 630                 635                 640 
Gly Met Leu Asp Asn Ile Leu Ala Ser Lys Leu Tyr Arg Pro Gly Ser
                645                 650                 655     
Val Ala Tyr Val Ser Arg Ser Gly Gly Met Ser Asn Glu Leu Asn Asn
            660                 665                 670         
Ile Ile Ser Arg Thr Thr Asp Gly Val Tyr Glu Gly Val Ala Ile Gly
        675                 680                 685             
Gly Asp Arg Tyr Pro Gly Ser Thr Phe Met Asp His Val Leu Arg Tyr
    690                 695                 700                 
Gln Asp Thr Pro Gly Val Lys Met Ile Val Val Leu Gly Glu Ile Gly
705                 710                 715                 720 
Gly Thr Glu Glu Tyr Lys Ile Cys Arg Gly Ile Lys Glu Gly Arg Leu
                725                 730                 735     
Thr Lys Pro Ile Val Cys Trp Cys Ile Gly Thr Cys Ala Thr Met Phe
            740                 745                 750         
Ser Ser Glu Val Gln Phe Gly His Ala Gly Ala Cys Ala Asn Gln Ala
        755                 760                 765             
Ser Glu Thr Ala Val Ala Lys Asn Gln Ala Leu Lys Glu Ala Gly Val
    770                 775                 780                 
Phe Val Pro Arg Ser Phe Asp Glu Leu Gly Glu Ile Ile Gln Ser Val
785                 790                 795                 800 
Tyr Glu Asp Leu Val Ala Asn Gly Val Ile Val Pro Ala Gln Glu Val
                805                 810                 815     
Pro Pro Pro Thr Val Pro Met Asp Tyr Ser Trp Ala Arg Glu Leu Gly
            820                 825                 830         
Leu Ile Arg Lys Pro Ala Ser Phe Met Thr Ser Ile Cys Asp Glu Arg
        835                 840                 845             
Gly Gln Glu Leu Ile Tyr Ala Gly Met Pro Ile Thr Glu Val Phe Lys
    850                 855                 860                 
Glu Glu Met Gly Ile Gly Gly Val Leu Gly Leu Leu Trp Phe Gln Lys
865                 870                 875                 880 
Arg Leu Pro Lys Tyr Ser Cys Gln Phe Ile Glu Met Cys Leu Met Val
                885                 890                 895     
Thr Ala Asp His Gly Pro Ala Val Ser Gly Ala His Asn Thr Ile Ile
            900                 905                 910         
Cys Ala Arg Ala Gly Lys Asp Leu Val Ser Ser Leu Thr Ser Gly Leu
        915                 920                 925             
Leu Thr Ile Gly Asp Arg Phe Gly Gly Ala Leu Asp Ala Ala Ala Lys
    930                 935                 940                 
Met Phe Ser Lys Ala Phe Asp Ser Gly Ile Ile Pro Met Glu Phe Val
945                 950                 955                 960 
Asn Lys Met Lys Lys Glu Gly Lys Leu Ile Met Gly Ile Gly His Arg
                965                 970                 975     
Val Lys Ser Ile Asn Asn Pro Asp Met Arg Val Gln Ile Leu Lys Asp
            980                 985                 990         
Tyr Val Arg Gln His Phe Pro Ala Thr Pro Leu Leu Asp Tyr Ala Leu
        995                 1000                1005            
Glu Val Glu Lys Ile Thr Thr Ser Lys Lys Pro Asn Leu Ile Leu Asn
    1010                1015                1020                
Val Asp Gly Leu Ile Gly Val Ala Phe Val Asp Met Leu Arg Asn Cys
1025                1030                1035               1040 
Gly Ser Phe Thr Arg Glu Glu Ala Asp Glu Tyr Ile Asp Ile Gly Ala
                1045                1050                1055    
Leu Asn Gly Ile Phe Val Leu Gly Arg Ser Met Gly Phe Ile Gly His
            1060                1065                1070        
Tyr Leu Asp Gln Lys Arg Leu Lys Gln Gly Leu Tyr Arg His Pro Trp
        1075                1080                1085            
Asp Asp Ile Ser Tyr Val Leu Pro Glu His Met Ser Met
    1090                1095                1100    


<210> 8
<211> 499
<212> PRT
<213> Homo sapiens

<400> 8
Met Ala Ser Thr Thr Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu
 1               5                  10                  15      
Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Met
            20                  25                  30          
Lys Ile Pro Thr Gly Gln Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys
        35                  40                  45              
Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile
    50                  55                  60                  
Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile
65                  70                  75                  80  
Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly
                85                  90                  95      
Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp
            100                 105                 110         
Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ser Val Asn His Cys His
        115                 120                 125             
Leu Asn Gly Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu
    130                 135                 140                 
Ala Ser Lys Ser Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu
145                 150                 155                 160 
Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly
                165                 170                 175     
Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly
            180                 185                 190         
Lys Pro Val Asp Met Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu
        195                 200                 205             
Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Arg Leu Tyr Gln
    210                 215                 220                 
Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr
225                 230                 235                 240 
Val Thr Pro Glu Ala Lys Asp Leu Ile Asn Lys Met Leu Thr Ile Asn
                245                 250                 255     
Pro Ala Lys Arg Ile Thr Ala Ser Glu Ala Leu Lys His Pro Trp Ile
            260                 265                 270         
Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val
        275                 280                 285             
Asp Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile
    290                 295                 300                 
Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Ala Ala Lys Ser Leu
305                 310                 315                 320 
Leu Lys Lys Pro Asp Gly Val Lys Glu Ser Thr Glu Ser Ser Asn Thr
                325                 330                 335     
Thr Ile Glu Asp Glu Asp Val Lys Ala Arg Lys Gln Glu Ile Ile Lys
            340                 345                 350         
Val Thr Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu Ala
        355                 360                 365             
Tyr Thr Lys Ile Cys Asp Pro Gly Leu Thr Ala Phe Glu Pro Glu Ala
    370                 375                 380                 
Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu
385                 390                 395                 400 
Asn Ala Leu Ser Lys Ser Asn Lys Pro Ile His Thr Ile Ile Leu Asn
                405                 410                 415     
Pro His Val His Leu Val Gly Asp Asp Ala Ala Cys Ile Ala Tyr Ile
            420                 425                 430         
Arg Leu Thr Gln Tyr Met Asp Gly Ser Gly Met Pro Lys Thr Met Gln
        435                 440                 445             
Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn
    450                 455                 460                 
Val His Phe His Arg Ser Gly Ser Pro Thr Val Pro Ile Lys Pro Pro
465                 470                 475                 480 
Cys Ile Pro Asn Gly Lys Glu Asn Phe Ser Gly Gly Thr Ser Leu Trp
                485                 490                 495     
Gln Asn Ile
            


<210> 9
<211> 681
<212> PRT
<213> Homo sapiens

<400> 9
Met Phe Arg Lys Lys Lys Lys Lys Arg Pro Glu Ile Ser Ala Pro Gln
 1               5                  10                  15      
Asn Phe Gln His Arg Val His Thr Ser Phe Asp Pro Lys Glu Gly Lys
            20                  25                  30          
Phe Val Gly Leu Pro Pro Gln Trp Gln Asn Ile Leu Asp Thr Leu Arg
        35                  40                  45              
Arg Pro Lys Pro Val Val Asp Pro Ser Arg Ile Thr Arg Val Gln Leu
    50                  55                  60                  
Gln Pro Met Lys Thr Val Val Arg Gly Ser Ala Met Pro Val Asp Gly
65                  70                  75                  80  
Tyr Ile Ser Gly Leu Leu Asn Asp Ile Gln Lys Leu Ser Val Ile Ser
                85                  90                  95      
Ser Asn Thr Leu Arg Gly Arg Ser Pro Thr Ser Arg Arg Arg Ala Gln
            100                 105                 110         
Ser Leu Gly Leu Leu Gly Asp Glu His Trp Ala Thr Asp Pro Asp Met
        115                 120                 125             
Tyr Leu Gln Ser Pro Gln Ser Glu Arg Thr Asp Pro His Gly Leu Tyr
    130                 135                 140                 
Leu Ser Cys Asn Gly Gly Thr Pro Ala Gly His Lys Gln Met Pro Trp
145                 150                 155                 160 
Pro Glu Pro Gln Ser Pro Arg Val Leu Pro Asn Gly Leu Ala Ala Lys
                165                 170                 175     
Ala Gln Ser Leu Gly Pro Ala Glu Phe Gln Gly Ala Ser Gln Arg Cys
            180                 185                 190         
Leu Gln Leu Gly Ala Cys Leu Gln Ser Ser Pro Pro Gly Ala Ser Pro
        195                 200                 205             
Pro Thr Gly Thr Asn Arg His Gly Met Lys Ala Ala Lys His Gly Ser
    210                 215                 220                 
Glu Glu Ala Arg Pro Gln Ser Cys Leu Val Gly Ser Ala Thr Gly Arg
225                 230                 235                 240 
Pro Gly Gly Glu Gly Ser Pro Ser Pro Lys Thr Arg Glu Ser Ser Leu
                245                 250                 255     
Lys Arg Arg Leu Phe Arg Ser Met Phe Leu Ser Thr Ala Ala Thr Ala
            260                 265                 270         
Pro Pro Ser Ser Ser Lys Pro Gly Pro Pro Pro Gln Ser Lys Pro Asn
        275                 280                 285             
Ser Ser Phe Arg Pro Pro Gln Lys Asp Asn Pro Pro Ser Leu Val Ala
    290                 295                 300                 
Lys Ala Gln Ser Leu Pro Ser Asp Gln Pro Val Gly Thr Phe Ser Pro
305                 310                 315                 320 
Leu Thr Thr Ser Asp Thr Ser Ser Pro Gln Lys Ser Leu Arg Thr Ala
                325                 330                 335     
Pro Ala Thr Gly Gln Leu Pro Gly Arg Ser Ser Pro Ala Gly Ser Pro
            340                 345                 350         
Arg Thr Trp His Ala Gln Ile Ser Thr Ser Asn Leu Tyr Leu Pro Gln
        355                 360                 365             
Asp Pro Thr Val Ala Lys Gly Ala Leu Ala Gly Glu Asp Thr Gly Val
    370                 375                 380                 
Val Thr His Glu Gln Phe Lys Ala Ala Leu Arg Met Val Val Asp Gln
385                 390                 395                 400 
Gly Asp Pro Arg Leu Leu Leu Asp Ser Tyr Val Lys Ile Gly Glu Gly
                405                 410                 415     
Ser Thr Gly Ile Val Cys Leu Ala Arg Glu Lys His Ser Gly Arg Gln
            420                 425                 430         
Val Ala Val Lys Met Met Asp Leu Arg Lys Gln Gln Arg Arg Glu Leu
        435                 440                 445             
Leu Phe Asn Glu Val Val Ile Met Arg Asp Tyr Gln His Phe Asn Val
    450                 455                 460                 
Val Glu Met Tyr Lys Ser Tyr Leu Val Gly Glu Glu Leu Trp Val Leu
465                 470                 475                 480 
Met Glu Phe Leu Gln Gly Gly Ala Leu Thr Asp Ile Val Ser Gln Val
                485                 490                 495     
Arg Leu Asn Glu Glu Gln Ile Ala Thr Val Cys Glu Ala Val Leu Gln
            500                 505                 510         
Ala Leu Ala Tyr Leu His Ala Gln Gly Val Ile His Arg Asp Ile Lys
        515                 520                 525             
Ser Asp Ser Ile Leu Leu Thr Leu Asp Gly Arg Val Lys Leu Ser Asp
    530                 535                 540                 
Phe Gly Phe Cys Ala Gln Ile Ser Lys Asp Val Pro Lys Arg Lys Ser
545                 550                 555                 560 
Leu Val Gly Thr Pro Tyr Trp Met Ala Pro Glu Val Ile Ser Arg Ser
                565                 570                 575     
Leu Tyr Ala Thr Glu Val Asp Ile Trp Ser Leu Gly Ile Met Val Ile
            580                 585                 590         
Glu Met Val Asp Gly Glu Pro Pro Tyr Phe Ser Asp Ser Pro Val Gln
        595                 600                 605             
Ala Met Lys Arg Leu Arg Asp Ser Pro Pro Pro Lys Leu Lys Asn Ser
    610                 615                 620                 
His Lys Val Ser Pro Val Leu Arg Asp Phe Leu Glu Arg Met Leu Val
625                 630                 635                 640 
Arg Asp Pro Gln Glu Arg Ala Thr Ala Gln Glu Leu Leu Asp His Pro
                645                 650                 655     
Phe Leu Leu Gln Thr Gly Leu Pro Glu Cys Leu Val Pro Leu Ile Gln
            660                 665                 670         
Leu Tyr Arg Lys Gln Thr Ser Thr Cys
        675                 680     


<210> 10
<211> 415
<212> PRT
<213> Homo sapiens

<400> 10
Met Glu Leu Arg Val Gly Asn Arg Tyr Arg Leu Gly Arg Lys Ile Gly
 1               5                  10                  15      
Ser Gly Ser Phe Gly Asp Ile Tyr Leu Gly Thr Asp Ile Ala Ala Gly
            20                  25                  30          
Glu Glu Val Ala Ile Lys Leu Glu Cys Val Lys Thr Lys His Pro Gln
        35                  40                  45              
Leu His Ile Glu Ser Lys Ile Tyr Lys Met Met Gln Gly Gly Val Gly
    50                  55                  60                  
Ile Pro Thr Ile Arg Trp Cys Gly Ala Glu Gly Asp Tyr Asn Val Met
65                  70                  75                  80  
Val Met Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu Phe Asn Phe Cys
                85                  90                  95      
Ser Arg Lys Phe Ser Leu Lys Thr Val Leu Leu Leu Ala Asp Gln Met
            100                 105                 110         
Ile Ser Arg Ile Glu Tyr Ile His Ser Lys Asn Phe Ile His Arg Asp
        115                 120                 125             
Val Lys Pro Asp Asn Phe Leu Met Gly Leu Gly Lys Lys Gly Asn Leu
    130                 135                 140                 
Val Tyr Ile Ile Asp Phe Gly Leu Ala Lys Lys Tyr Arg Asp Ala Arg
145                 150                 155                 160 
Thr His Gln His Ile Pro Tyr Arg Glu Asn Lys Asn Leu Thr Gly Thr
                165                 170                 175     
Ala Arg Tyr Ala Ser Ile Asn Thr His Leu Gly Ile Glu Gln Ser Arg
            180                 185                 190         
Arg Asp Asp Leu Glu Ser Leu Gly Tyr Val Leu Met Tyr Phe Asn Leu
        195                 200                 205             
Gly Ser Leu Pro Trp Gln Gly Leu Lys Ala Ala Thr Lys Arg Gln Lys
    210                 215                 220                 
Tyr Glu Arg Ile Ser Glu Lys Lys Met Ser Thr Pro Ile Glu Val Leu
225                 230                 235                 240 
Cys Lys Gly Tyr Pro Ser Glu Phe Ala Thr Tyr Leu Asn Phe Cys Arg
                245                 250                 255     
Ser Leu Arg Phe Asp Asp Lys Pro Asp Tyr Ser Tyr Leu Arg Gln Leu
            260                 265                 270         
Phe Arg Asn Leu Phe His Arg Gln Gly Phe Ser Tyr Asp Tyr Val Phe
        275                 280                 285             
Asp Trp Asn Met Leu Lys Phe Gly Ala Ser Arg Ala Ala Asp Asp Ala
    290                 295                 300                 
Glu Arg Glu Arg Arg Asp Arg Glu Glu Arg Leu Arg His Ser Arg Asn
305                 310                 315                 320 
Pro Ala Thr Arg Gly Leu Pro Ser Thr Ala Ser Gly Arg Leu Arg Gly
                325                 330                 335     
Thr Gln Glu Val Ala Pro Pro Thr Pro Leu Thr Pro Thr Ser His Thr
            340                 345                 350         
Ala Asn Thr Ser Pro Arg Pro Val Ser Gly Met Glu Arg Glu Arg Lys
        355                 360                 365             
Val Ser Met Arg Leu His Arg Gly Ala Pro Val Asn Ile Ser Ser Ser
    370                 375                 380                 
Asp Leu Thr Gly Arg Gln Asp Thr Ser Arg Met Ser Thr Ser Gln Ile
385                 390                 395                 400 
Pro Gly Arg Val Ala Ser Ser Gly Leu Gln Ser Val Val His Arg
                405                 410                 415 


<210> 11
<211> 415
<212> PRT
<213> Homo sapiens

<400> 11
Met Asp Phe Asp Lys Lys Gly Gly Lys Gly Glu Thr Glu Glu Gly Arg
 1               5                  10                  15      
Arg Met Ser Lys Ala Gly Gly Gly Arg Ser Ser His Gly Ile Arg Ser
            20                  25                  30          
Ser Gly Thr Ser Ser Gly Val Leu Met Val Gly Pro Asn Phe Arg Val
        35                  40                  45              
Gly Lys Lys Ile Gly Cys Gly Asn Phe Gly Glu Leu Arg Leu Gly Lys
    50                  55                  60                  
Asn Leu Tyr Thr Asn Glu Tyr Val Ala Ile Lys Leu Glu Pro Ile Lys
65                  70                  75                  80  
Ser Arg Ala Pro Gln Leu His Leu Glu Tyr Arg Phe Tyr Lys Gln Leu
                85                  90                  95      
Ser Ala Thr Glu Gly Val Pro Gln Val Tyr Tyr Phe Gly Pro Cys Gly
            100                 105                 110         
Lys Tyr Asn Ala Met Val Leu Glu Leu Leu Gly Pro Ser Leu Glu Asp
        115                 120                 125             
Leu Phe Asp Leu Cys Asp Arg Thr Phe Thr Leu Lys Thr Val Leu Met
    130                 135                 140                 
Ile Ala Ile Gln Leu Ile Thr Arg Met Glu Tyr Val His Thr Lys Ser
145                 150                 155                 160 
Leu Ile Tyr Arg Asp Val Lys Pro Glu Asn Phe Leu Val Gly Arg Pro
                165                 170                 175     
Gly Thr Lys Arg Gln His Ala Ile His Ile Ile Asp Phe Gly Leu Ala
            180                 185                 190         
Lys Glu Tyr Ile Asp Pro Glu Thr Lys Lys His Ile Pro Tyr Arg Glu
        195                 200                 205             
His Lys Ser Leu Thr Gly Thr Ala Arg Tyr Met Ser Ile Asn Thr His
    210                 215                 220                 
Leu Gly Lys Glu Gln Ser Arg Arg Asp Asp Leu Glu Ala Leu Gly His
225                 230                 235                 240 
Met Phe Met Tyr Phe Leu Arg Gly Ser Leu Pro Trp Gln Gly Leu Lys
                245                 250                 255     
Ala Asp Thr Leu Lys Glu Arg Tyr Gln Lys Ile Gly Asp Thr Lys Arg
            260                 265                 270         
Ala Thr Pro Ile Glu Val Leu Cys Glu Asn Phe Pro Glu Glu Met Ala
        275                 280                 285             
Thr Tyr Leu Arg Tyr Val Arg Arg Leu Asp Phe Phe Glu Lys Pro Asp
    290                 295                 300                 
Tyr Asp Tyr Leu Arg Lys Leu Phe Thr Asp Leu Phe Asp Arg Ser Gly
305                 310                 315                 320 
Phe Val Phe Asp Tyr Glu Tyr Asp Trp Ala Gly Lys Pro Leu Pro Thr
                325                 330                 335     
Pro Ile Gly Thr Val His Thr Asp Leu Pro Ser Gln Pro Gln Leu Arg
            340                 345                 350         
Asp Lys Thr Gln Pro His Ser Lys Asn Gln Ala Leu Asn Ser Thr Asn
        355                 360                 365             
Gly Glu Leu Asn Ala Asp Asp Pro Thr Ala Gly His Ser Asn Ala Pro
    370                 375                 380                 
Ile Thr Ala Pro Ala Glu Val Glu Val Ala Asp Glu Thr Lys Cys Cys
385                 390                 395                 400 
Cys Phe Phe Lys Arg Arg Lys Arg Lys Ser Leu Gln Arg His Lys
                405                 410                 415 


<210> 12
<211> 317
<212> PRT
<213> Homo sapiens

<400> 12
Met Arg Lys Thr Ser Asn Ser Cys Ile Met Glu Asn Gly His Gln Pro
 1               5                  10                  15      
Gly Thr Gly Pro Gly Asp Gly Pro Pro Glu Ile Ala Gln Asn Phe Ser
            20                  25                  30          
Ala Pro Asp Pro Pro Arg Pro Arg Pro Val Ser Leu Ser Leu Arg Leu
        35                  40                  45              
Pro His Gln Pro Val Thr Ala Ile Thr Arg Val Ser Asp Arg Phe Ser
    50                  55                  60                  
Gly Glu Thr Ser Ala Ala Ala Leu Ser Pro Met Ser Ala Ala Thr Leu
65                  70                  75                  80  
Gly Gly Leu Asn Pro Ser Pro Ser Glu Val Ile Thr Pro Trp Thr Pro
                85                  90                  95      
Ser Pro Ser Glu Lys Asn Ser Ser Phe Thr Trp Ser Val Pro Ser Ser
            100                 105                 110         
Gly Tyr Gly Ala Val Thr Ala Ser Lys His Ser Asn Ser Pro Pro Leu
        115                 120                 125             
Val Thr Pro Pro Gln Ser Pro Val Ser Pro Gln Pro Pro Ala Ile Thr
    130                 135                 140                 
Gln Val His Arg Gln Gly Glu Arg Arg Arg Glu Leu Val Arg Ser Gln
145                 150                 155                 160 
Thr Leu Pro Arg Thr Ser Glu Ala Gln Ala Arg Lys Ala Leu Phe Glu
                165                 170                 175     
Lys Trp Glu Gln Glu Thr Ala Ala Gly Lys Gly Lys Gly Glu Ala Arg
            180                 185                 190         
Ala Arg Leu Lys Arg Ser Gln Ser Phe Gly Val Ala Ser Ala Ser Ser
        195                 200                 205             
Ile Lys Gln Ile Leu Leu Glu Trp Cys Arg Ser Lys Thr Leu Gly Tyr
    210                 215                 220                 
Gln His Val Asp Leu Gln Asn Phe Ser Ser Ser Trp Ser Asp Gly Met
225                 230                 235                 240 
Ala Phe Cys Ala Leu Val His Ser Phe Phe Pro Asp Ala Phe Asp Tyr
                245                 250                 255     
Asn Ser Leu Ser Pro Thr Gln Arg Gln Lys Asn Phe Glu Leu Ala Phe
            260                 265                 270         
Thr Met Ala Glu Asn Leu Ala Asn Cys Glu Arg Leu Ile Glu Val Glu
        275                 280                 285             
Asp Met Met Val Met Gly Arg Lys Pro Asp Pro Met Cys Val Phe Thr
    290                 295                 300                 
Tyr Val Gln Ser Leu Tyr Asn His Leu Arg Arg Phe Glu
305                 310                 315         


<210> 13
<211> 688
<212> PRT
<213> Homo sapiens

<400> 13
Met Ser Ser Arg Thr Val Leu Ala Pro Gly Asn Asp Arg Asn Ser Asp
 1               5                  10                  15      
Thr His Gly Thr Leu Gly Ser Gly Arg Ser Ser Asp Lys Gly Pro Ser
            20                  25                  30          
Trp Ser Ser Arg Ser Leu Gly Ala Arg Cys Arg Asn Ser Ile Ala Ser
        35                  40                  45              
Cys Pro Glu Glu Gln Pro His Val Gly Asn Tyr Arg Leu Leu Arg Thr
    50                  55                  60                  
Ile Gly Lys Gly Asn Phe Ala Lys Val Lys Leu Ala Arg His Ile Leu
65                  70                  75                  80  
Thr Gly Arg Glu Val Ala Ile Lys Ile Ile Asp Lys Thr Gln Leu Asn
                85                  90                  95      
Pro Ser Ser Leu Gln Lys Leu Phe Arg Glu Val Arg Ile Met Lys Gly
            100                 105                 110         
Leu Asn His Pro Asn Ile Val Lys Leu Phe Glu Val Ile Glu Thr Glu
        115                 120                 125             
Lys Thr Leu Tyr Leu Val Met Glu Tyr Ala Ser Ala Gly Glu Val Phe
    130                 135                 140                 
Asp Tyr Leu Val Ser His Gly Arg Met Lys Glu Lys Glu Ala Arg Ala
145                 150                 155                 160 
Lys Phe Arg Gln Ile Val Ser Ala Val His Tyr Cys His Gln Lys Asn
                165                 170                 175     
Ile Val His Arg Asp Leu Lys Ala Glu Asn Leu Leu Leu Asp Ala Glu
            180                 185                 190         
Ala Asn Ile Lys Ile Ala Asp Phe Gly Phe Ser Asn Glu Phe Thr Leu
        195                 200                 205             
Gly Ser Lys Leu Asp Thr Phe Cys Gly Ser Pro Pro Tyr Ala Ala Pro
    210                 215                 220                 
Glu Leu Phe Gln Gly Lys Lys Tyr Asp Gly Pro Glu Val Asp Ile Trp
225                 230                 235                 240 
Ser Leu Gly Val Ile Leu Tyr Thr Leu Val Ser Gly Ser Leu Pro Phe
                245                 250                 255     
Asp Gly His Asn Leu Lys Glu Leu Arg Glu Arg Val Leu Arg Gly Lys
            260                 265                 270         
Tyr Arg Val Pro Phe Tyr Met Ser Thr Asp Cys Glu Ser Ile Leu Arg
        275                 280                 285             
Arg Phe Leu Val Leu Asn Pro Ala Lys Arg Cys Thr Leu Glu Gln Ile
    290                 295                 300                 
Met Lys Asp Lys Trp Ile Asn Ile Gly Tyr Glu Gly Glu Glu Leu Lys
305                 310                 315                 320 
Pro Tyr Thr Glu Pro Glu Glu Asp Phe Gly Asp Thr Lys Arg Ile Glu
                325                 330                 335     
Val Met Val Gly Met Gly Tyr Thr Arg Glu Glu Ile Lys Glu Ser Leu
            340                 345                 350         
Thr Ser Gln Lys Tyr Asn Glu Val Thr Ala Thr Tyr Leu Leu Leu Gly
        355                 360                 365             
Arg Lys Thr Glu Glu Gly Gly Asp Arg Gly Ala Pro Gly Leu Ala Leu
    370                 375                 380                 
Ala Arg Val Arg Ala Pro Ser Asp Thr Thr Asn Gly Thr Ser Ser Ser
385                 390                 395                 400 
Lys Gly Thr Ser His Ser Lys Gly Gln Arg Ser Ser Ser Ser Thr Tyr
                405                 410                 415     
His Arg Gln Arg Arg His Ser Asp Phe Cys Gly Pro Ser Pro Ala Pro
            420                 425                 430         
Leu His Pro Lys Arg Ser Pro Thr Ser Thr Gly Glu Ala Glu Leu Lys
        435                 440                 445             
Glu Glu Arg Leu Pro Gly Arg Lys Ala Ser Cys Ser Thr Ala Gly Ser
    450                 455                 460                 
Gly Ser Arg Gly Leu Pro Pro Ser Ser Pro Met Val Ser Ser Ala His
465                 470                 475                 480 
Asn Pro Asn Lys Ala Glu Ile Pro Glu Arg Arg Lys Asp Ser Thr Ser
                485                 490                 495     
Thr Pro Asn Asn Leu Pro Pro Ser Met Met Thr Arg Arg Asn Thr Tyr
            500                 505                 510         
Val Cys Thr Glu Arg Pro Gly Ala Glu Arg Pro Ser Leu Leu Pro Asn
        515                 520                 525             
Gly Lys Glu Asn Ser Ser Gly Thr Pro Arg Val Pro Pro Ala Ser Pro
    530                 535                 540                 
Ser Ser His Ser Leu Ala Pro Pro Ser Gly Glu Arg Ser Arg Leu Ala
545                 550                 555                 560 
Arg Gly Ser Thr Ile Arg Ser Thr Phe His Gly Gly Gln Val Arg Asp
                565                 570                 575     
Arg Arg Ala Gly Gly Gly Gly Gly Gly Gly Val Gln Asn Gly Pro Pro
            580                 585                 590         
Ala Ser Pro Thr Leu Ala His Glu Ala Ala Pro Leu Pro Ala Gly Arg
        595                 600                 605             
Pro Arg Pro Thr Thr Asn Leu Phe Thr Lys Leu Thr Ser Lys Leu Thr
    610                 615                 620                 
Arg Arg Val Thr Leu Asp Pro Ser Lys Arg Gln Asn Ser Asn Arg Cys
625                 630                 635                 640 
Val Ser Gly Ala Ser Leu Pro Gln Gly Ser Lys Ile Arg Ser Gln Thr
                645                 650                 655     
Asn Leu Arg Glu Ser Gly Asp Leu Arg Ser Gln Val Ala Ile Tyr Leu
            660                 665                 670         
Gly Ile Lys Arg Lys Pro Pro Pro Gly Cys Ser Asp Ser Pro Gly Val
        675                 680                 685             


<210> 14
<211> 167
<212> PRT
<213> Homo sapiens

<400> 14
Met Glu Glu Thr Tyr Thr Asp Ser Leu Asp Pro Glu Lys Leu Leu Gln
 1               5                  10                  15      
Cys Pro Tyr Asp Lys Asn His Gln Ile Arg Ala Cys Arg Phe Pro Tyr
            20                  25                  30          
His Leu Ile Lys Cys Arg Lys Asn His Pro Asp Val Ala Ser Lys Leu
        35                  40                  45              
Ala Thr Cys Pro Phe Asn Ala Arg His Gln Val Pro Arg Ala Glu Ile
    50                  55                  60                  
Ser His His Ile Ser Ser Cys Asp Asp Arg Ser Cys Ile Glu Gln Asp
65                  70                  75                  80  
Val Val Asn Gln Thr Arg Ser Leu Arg Gln Glu Thr Leu Ala Glu Ser
                85                  90                  95      
Thr Trp Gln Cys Pro Pro Cys Asp Glu Asp Trp Asp Lys Asp Leu Trp
            100                 105                 110         
Glu Gln Thr Ser Thr Pro Phe Val Trp Gly Thr Thr His Tyr Ser Asp
        115                 120                 125             
Asn Asn Ser Pro Ala Ser Asn Ile Val Thr Glu His Lys Asn Asn Leu
    130                 135                 140                 
Ala Ser Gly Met Arg Val Pro Lys Ser Leu Pro Tyr Val Leu Pro Trp
145                 150                 155                 160 
Lys Asn Asn Gly Asn Ala Gln
                165         


<210> 15
<211> 325
<212> PRT
<213> Homo sapiens

<400> 15
Met Lys Glu Met Val Gly Gly Cys Cys Val Cys Ser Asp Glu Arg Gly
 1               5                  10                  15      
Trp Ala Glu Asn Pro Leu Val Tyr Cys Asp Gly His Ala Cys Ser Val
            20                  25                  30          
Ala Val His Gln Ala Cys Tyr Gly Ile Val Gln Val Pro Thr Gly Pro
        35                  40                  45              
Trp Phe Cys Arg Lys Cys Glu Ser Gln Glu Arg Ala Ala Arg Val Arg
    50                  55                  60                  
Cys Glu Leu Cys Pro His Lys Asp Gly Ala Leu Lys Arg Thr Asp Asn
65                  70                  75                  80  
Gly Gly Trp Ala His Val Val Cys Ala Leu Tyr Ile Pro Glu Val Gln
                85                  90                  95      
Phe Ala Asn Val Leu Thr Met Glu Pro Ile Val Leu Gln Tyr Val Pro
            100                 105                 110         
His Asp Arg Phe Asn Lys Thr Cys Tyr Ile Cys Glu Glu Gln Gly Arg
        115                 120                 125             
Glu Ser Lys Ala Ala Ser Gly Ala Cys Met Thr Cys Asn Arg His Gly
    130                 135                 140                 
Cys Arg Gln Ala Phe His Val Thr Cys Ala Gln Met Ala Gly Leu Leu
145                 150                 155                 160 
Cys Glu Glu Glu Val Leu Glu Val Asp Asn Val Lys Tyr Cys Gly Tyr
                165                 170                 175     
Cys Lys Tyr His Phe Ser Lys Met Lys Thr Ser Arg His Ser Ser Gly
            180                 185                 190         
Gly Gly Gly Gly Gly Ala Gly Gly Gly Gly Gly Ser Met Gly Gly Gly
        195                 200                 205             
Gly Ser Gly Phe Ile Ser Gly Arg Arg Ser Arg Ser Ala Ser Pro Ser
    210                 215                 220                 
Thr Gln Gln Glu Lys His Pro Thr His His Glu Arg Gly Gln Lys Lys
225                 230                 235                 240 
Ser Arg Lys Asp Lys Glu Arg Leu Lys Gln Lys His Lys Lys Arg Pro
                245                 250                 255     
Glu Ser Pro Pro Ser Ile Leu Thr Pro Pro Val Val Pro Thr Ala Asp
            260                 265                 270         
Lys Pro Arg Arg Gly His Gln Ser Pro Thr Asn His Gly Ile Gly Ser
        275                 280                 285             
Leu Gly Cys Cys Leu Pro Asp Thr Pro Ile Cys Leu Cys Pro Glu Gly
    290                 295                 300                 
Leu Ser Pro Gly Leu Leu Ser Ala Glu Ser Gly Gly Arg His Ser Gly
305                 310                 315                 320 
Leu Leu Ser Lys Phe
                325 


<210> 16
<211> 1072
<212> PRT
<213> Homo sapiens

<400> 16
Met Ala Lys Ala Thr Ser Gly Ala Ala Gly Leu Arg Leu Leu Leu Leu
 1               5                  10                  15      
Leu Leu Leu Pro Leu Leu Gly Lys Val Ala Leu Gly Leu Tyr Phe Ser
            20                  25                  30          
Arg Asp Ala Tyr Trp Glu Lys Leu Tyr Val Asp Gln Ala Ala Gly Thr
        35                  40                  45              
Pro Leu Leu Tyr Val His Ala Leu Arg Asp Ala Pro Glu Glu Val Pro
    50                  55                  60                  
Ser Phe Arg Leu Gly Gln His Leu Tyr Gly Thr Tyr Arg Thr Arg Leu
65                  70                  75                  80  
His Glu Asn Asn Trp Ile Cys Ile Gln Glu Asp Thr Gly Leu Leu Tyr
                85                  90                  95      
Leu Asn Arg Ser Leu Asp His Ser Ser Trp Glu Lys Leu Ser Val Arg
            100                 105                 110         
Asn Arg Gly Phe Pro Leu Leu Thr Val Tyr Leu Lys Val Phe Leu Ser
        115                 120                 125             
Pro Thr Ser Leu Arg Glu Gly Glu Cys Gln Trp Pro Gly Cys Ala Arg
    130                 135                 140                 
Val Tyr Phe Ser Phe Phe Asn Thr Ser Phe Pro Ala Cys Ser Ser Leu
145                 150                 155                 160 
Lys Pro Arg Glu Leu Cys Phe Pro Glu Thr Arg Pro Ser Phe Arg Ile
                165                 170                 175     
Arg Glu Asn Arg Pro Pro Gly Thr Phe His Gln Phe Arg Leu Leu Pro
            180                 185                 190         
Val Gln Phe Leu Cys Pro Asn Ile Ser Val Ala Tyr Arg Leu Leu Glu
        195                 200                 205             
Gly Glu Gly Leu Pro Phe Arg Cys Ala Pro Asp Ser Leu Glu Val Ser
    210                 215                 220                 
Thr Arg Trp Ala Leu Asp Arg Glu Gln Arg Glu Lys Tyr Glu Leu Val
225                 230                 235                 240 
Ala Val Cys Thr Val His Ala Gly Ala Arg Glu Glu Val Val Met Val
                245                 250                 255     
Pro Phe Pro Val Thr Val Tyr Asp Glu Asp Asp Ser Ala Pro Thr Phe
            260                 265                 270         
Pro Ala Gly Val Asp Thr Ala Ser Ala Val Val Glu Phe Lys Arg Lys
        275                 280                 285             
Glu Asp Thr Val Val Ala Thr Leu Arg Val Phe Asp Ala Asp Val Val
    290                 295                 300                 
Pro Ala Ser Gly Glu Leu Val Arg Arg Tyr Thr Ser Thr Leu Leu Pro
305                 310                 315                 320 
Gly Asp Thr Trp Ala Gln Gln Thr Phe Arg Val Glu His Trp Pro Asn
                325                 330                 335     
Glu Thr Ser Val Gln Ala Asn Gly Ser Phe Val Arg Ala Thr Val His
            340                 345                 350         
Asp Tyr Arg Leu Val Leu Asn Arg Asn Leu Ser Ile Ser Glu Asn Arg
        355                 360                 365             
Thr Met Gln Leu Ala Val Leu Val Asn Asp Ser Asp Phe Gln Gly Pro
    370                 375                 380                 
Gly Ala Gly Val Leu Leu Leu His Phe Asn Val Ser Val Leu Pro Val
385                 390                 395                 400 
Ser Leu His Leu Pro Ser Thr Tyr Ser Leu Ser Val Ser Arg Arg Ala
                405                 410                 415     
Arg Arg Phe Ala Gln Ile Gly Lys Val Cys Val Glu Asn Cys Gln Ala
            420                 425                 430         
Phe Ser Gly Ile Asn Val Gln Tyr Lys Leu His Ser Ser Gly Ala Asn
        435                 440                 445             
Cys Ser Thr Leu Gly Val Val Thr Ser Ala Glu Asp Thr Ser Gly Ile
    450                 455                 460                 
Leu Phe Val Asn Asp Thr Lys Ala Leu Arg Arg Pro Lys Cys Ala Glu
465                 470                 475                 480 
Leu His Tyr Met Val Val Ala Thr Asp Gln Gln Thr Ser Arg Gln Ala
                485                 490                 495     
Gln Ala Gln Leu Leu Val Thr Val Glu Gly Ser Tyr Val Ala Glu Glu
            500                 505                 510         
Ala Gly Cys Pro Leu Ser Cys Ala Val Ser Lys Arg Arg Leu Glu Cys
        515                 520                 525             
Glu Glu Cys Gly Gly Leu Gly Ser Pro Thr Gly Arg Cys Glu Trp Arg
    530                 535                 540                 
Gln Gly Asp Gly Lys Gly Ile Thr Arg Asn Phe Ser Thr Cys Ser Pro
545                 550                 555                 560 
Ser Thr Lys Thr Cys Pro Asp Gly His Cys Asp Val Val Glu Thr Gln
                565                 570                 575     
Asp Ile Asn Ile Cys Pro Gln Asp Cys Leu Arg Gly Ser Ile Val Gly
            580                 585                 590         
Gly His Glu Pro Gly Glu Pro Arg Gly Ile Lys Ala Gly Tyr Gly Thr
        595                 600                 605             
Cys Asn Cys Phe Pro Glu Glu Glu Lys Cys Phe Cys Glu Pro Glu Asp
    610                 615                 620                 
Ile Gln Asp Pro Leu Cys Asp Glu Leu Cys Arg Thr Val Ile Ala Ala
625                 630                 635                 640 
Ala Val Leu Phe Ser Phe Ile Val Ser Val Leu Leu Ser Ala Phe Cys
                645                 650                 655     
Ile His Cys Tyr His Lys Phe Ala His Lys Pro Pro Ile Ser Ser Ala
            660                 665                 670         
Glu Met Thr Phe Arg Arg Pro Ala Gln Ala Phe Pro Val Ser Tyr Ser
        675                 680                 685             
Ser Ser Gly Ala Arg Arg Pro Ser Leu Asp Ser Met Glu Asn Gln Val
    690                 695                 700                 
Ser Val Asp Ala Phe Lys Ile Leu Glu Asp Pro Lys Trp Glu Phe Pro
705                 710                 715                 720 
Arg Lys Asn Leu Val Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly
                725                 730                 735     
Lys Val Val Lys Ala Thr Ala Phe His Leu Lys Gly Arg Ala Gly Tyr
            740                 745                 750         
Thr Thr Val Ala Val Lys Met Leu Lys Glu Asn Ala Ser Pro Ser Glu
        755                 760                 765             
Leu Arg Asp Leu Leu Ser Glu Phe Asn Val Leu Lys Gln Val Asn His
    770                 775                 780                 
Pro His Val Ile Lys Leu Tyr Gly Ala Cys Ser Gln Asp Gly Pro Leu
785                 790                 795                 800 
Leu Leu Ile Val Glu Tyr Ala Lys Tyr Gly Ser Leu Arg Gly Phe Leu
                805                 810                 815     
Arg Glu Ser Arg Lys Val Gly Pro Gly Tyr Leu Gly Ser Gly Gly Ser
            820                 825                 830         
Arg Asn Ser Ser Ser Leu Asp His Pro Asp Glu Arg Ala Leu Thr Met
        835                 840                 845             
Gly Asp Leu Ile Ser Phe Ala Trp Gln Ile Ser Gln Gly Met Gln Tyr
    850                 855                 860                 
Leu Ala Glu Met Lys Leu Val His Arg Asp Leu Ala Ala Arg Asn Ile
865                 870                 875                 880 
Leu Val Ala Glu Gly Arg Lys Met Lys Ile Ser Asp Phe Gly Leu Ser
                885                 890                 895     
Arg Asp Val Tyr Glu Glu Asp Ser Tyr Val Lys Arg Ser Gln Gly Arg
            900                 905                 910         
Ile Pro Val Lys Trp Met Ala Ile Glu Ser Leu Phe Asp His Ile Tyr
        915                 920                 925             
Thr Thr Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile
    930                 935                 940                 
Val Thr Leu Gly Gly Asn Pro Tyr Pro Gly Ile Pro Pro Glu Arg Leu
945                 950                 955                 960 
Phe Asn Leu Leu Lys Thr Gly His Arg Met Glu Arg Pro Asp Asn Cys
                965                 970                 975     
Ser Glu Glu Met Tyr Arg Leu Met Leu Gln Cys Trp Lys Gln Glu Pro
            980                 985                 990         
Asp Lys Arg Pro Val Phe Ala Asp Ile Ser Lys Asp Leu Glu Lys Met
        995                 1000                1005            
Met Val Lys Arg Arg Asp Tyr Leu Asp Leu Ala Ala Ser Thr Pro Ser
    1010                1015                1020                
Asp Ser Leu Ile Tyr Asp Asp Gly Leu Ser Glu Glu Glu Thr Pro Leu
1025                1030                1035               1040 
Val Asp Cys Asn Asn Ala Pro Leu Pro Arg Ala Leu Pro Ser Thr Trp
                1045                1050                1055    
Ile Glu Asn Lys Leu Tyr Gly Arg Ile Ser His Ala Phe Thr Arg Phe
            1060                1065                1070        


<210> 17
<211> 78
<212> PRT
<213> Homo sapiens

<400> 17
Met Ser Ala Thr Thr Ala Cys Trp Pro Ala Phe Thr Val Leu Gly Glu
 1               5                  10                  15      
Ala Arg Gly Asp Gln Val Asp Trp Ser Arg Leu Tyr Arg Asp Thr Gly
            20                  25                  30          
Leu Val Lys Met Ser Arg Lys Pro Arg Ala Ser Ser Pro Phe Ser Asn
        35                  40                  45              
Asn His Pro Ser Thr Pro Lys Arg Phe Pro Arg Gln Pro Arg Arg Glu
    50                  55                  60                  
Lys Gly Pro Val Lys Glu Val Pro Gly Thr Lys Gly Ser Pro
65                  70                  75              


<210> 18
<211> 210
<212> PRT
<213> Homo sapiens

<400> 18
Met Ser Leu Thr Ser Asp Ala Ser Ser Pro Arg Ser Tyr Val Ser Pro
 1               5                  10                  15      
Arg Ile Ser Thr Pro Gln Thr Asn Thr Val Pro Ile Lys Pro Leu Ile
            20                  25                  30          
Ser Thr Pro Pro Val Ser Ser Gln Pro Lys Val Ser Thr Pro Val Val
        35                  40                  45              
Lys Gln Gly Pro Val Ser Gln Ser Ala Thr Gln Gln Pro Val Thr Ala
    50                  55                  60                  
Asp Lys Gln Gln Gly His Glu Pro Val Ser Pro Arg Ser Leu Gln Arg
65                  70                  75                  80  
Ser Ser Ser Gln Arg Ser Pro Ser Pro Gly Pro Asn His Thr Ser Asn
                85                  90                  95      
Ser Ser Asn Ala Ser Asn Ala Thr Val Val Pro Gln Asn Ser Ser Ala
            100                 105                 110         
Arg Ser Thr Cys Ser Leu Thr Pro Ala Leu Ala Ala His Phe Ser Glu
        115                 120                 125             
Asn Leu Ile Lys His Val Gln Gly Trp Pro Ala Asp His Ala Glu Arg
    130                 135                 140                 
Gln Ala Ser Arg Leu Arg Glu Glu Ala His Asn Met Gly Thr Ile His
145                 150                 155                 160 
Met Ser Glu Ile Cys Thr Glu Leu Lys Asn Leu Arg Ser Leu Val Arg
                165                 170                 175     
Val Cys Glu Ile Gln Ala Thr Leu Arg Glu Gln Arg Ile Leu Phe Leu
            180                 185                 190         
Arg Gln Gln Ile Lys Glu Leu Glu Lys Leu Lys Asn Gln Asn Ser Phe
        195                 200                 205             
Met Val
    210 


<210> 19
<211> 287
<212> PRT
<213> Homo sapiens

<400> 19
Met His Arg Leu Met Gly Val Asn Ser Thr Ala Ala Ala Ala Ala Gly
 1               5                  10                  15      
Gln Pro Asn Val Ser Cys Thr Cys Asn Cys Lys Arg Ser Leu Phe Gln
            20                  25                  30          
Ser Met Glu Ile Thr Glu Leu Glu Phe Val Gln Ile Ile Ile Ile Val
        35                  40                  45              
Val Val Met Met Val Met Val Val Val Ile Thr Cys Leu Leu Ser His
    50                  55                  60                  
Tyr Lys Leu Ser Ala Arg Ser Phe Ile Ser Arg His Ser Gln Gly Arg
65                  70                  75                  80  
Arg Arg Glu Asp Ala Leu Ser Ser Glu Gly Cys Leu Trp Pro Ser Glu
                85                  90                  95      
Ser Thr Val Ser Gly Asn Gly Ile Pro Glu Pro Gln Val Tyr Ala Pro
            100                 105                 110         
Pro Arg Pro Thr Asp Arg Leu Ala Val Pro Pro Phe Ala Gln Arg Glu
        115                 120                 125             
Arg Phe His Arg Phe Gln Pro Thr Tyr Pro Tyr Leu Gln His Glu Ile
    130                 135                 140                 
Asp Leu Pro Pro Thr Ile Ser Leu Ser Asp Gly Glu Glu Pro Pro Pro
145                 150                 155                 160 
Tyr Gln Gly Pro Cys Thr Leu Gln Leu Arg Asp Pro Glu Gln Gln Leu
                165                 170                 175     
Glu Leu Asn Arg Glu Ser Val Arg Ala Pro Pro Asn Arg Thr Ile Phe
            180                 185                 190         
Asp Ser Asp Leu Met Asp Ser Ala Arg Leu Gly Gly Pro Cys Pro Pro
        195                 200                 205             
Ser Ser Asn Ser Gly Ile Ser Ala Thr Cys Tyr Gly Ser Gly Gly Arg
    210                 215                 220                 
Met Glu Gly Pro Pro Pro Thr Tyr Ser Glu Val Ile Gly His Tyr Pro
225                 230                 235                 240 
Gly Ser Ser Phe Gln His Gln Gln Ser Ser Gly Pro Pro Ser Leu Leu
                245                 250                 255     
Glu Gly Thr Arg Leu His His Thr His Ile Ala Pro Leu Glu Ser Ala
            260                 265                 270         
Ala Ile Trp Ser Lys Glu Lys Asp Lys Gln Lys Gly His Pro Leu
        275                 280                 285         


<210> 20
<211> 481
<212> PRT
<213> Homo sapiens

<400> 20
Met Asn Glu Val Ser Val Ile Lys Glu Gly Trp Leu His Lys Arg Gly
 1               5                  10                  15      
Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Ser Asp
            20                  25                  30          
Gly Ser Phe Ile Gly Tyr Lys Glu Arg Pro Glu Ala Pro Asp Gln Thr
        35                  40                  45              
Leu Pro Pro Leu Asn Asn Phe Ser Val Ala Glu Cys Gln Leu Met Lys
    50                  55                  60                  
Thr Glu Arg Pro Arg Pro Asn Thr Phe Val Ile Arg Cys Leu Gln Trp
65                  70                  75                  80  
Thr Thr Val Ile Glu Arg Thr Phe His Val Asp Ser Pro Asp Glu Arg
                85                  90                  95      
Glu Glu Trp Met Arg Ala Ile Gln Met Val Ala Asn Ser Leu Lys Gln
            100                 105                 110         
Arg Ala Pro Gly Glu Asp Pro Met Asp Tyr Lys Cys Gly Ser Pro Ser
        115                 120                 125             
Asp Ser Ser Thr Thr Glu Glu Met Glu Val Ala Val Ser Lys Ala Arg
    130                 135                 140                 
Ala Lys Val Thr Met Asn Asp Phe Asp Tyr Leu Lys Leu Leu Gly Lys
145                 150                 155                 160 
Gly Thr Phe Gly Lys Val Ile Leu Val Arg Glu Lys Ala Thr Gly Arg
                165                 170                 175     
Tyr Tyr Ala Met Lys Ile Leu Arg Lys Glu Val Ile Ile Ala Lys Asp
            180                 185                 190         
Glu Val Ala His Thr Val Thr Glu Ser Arg Val Leu Gln Asn Thr Arg
        195                 200                 205             
His Pro Phe Leu Thr Ala Leu Lys Tyr Ala Phe Gln Thr His Asp Arg
    210                 215                 220                 
Leu Cys Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His
225                 230                 235                 240 
Leu Ser Arg Glu Arg Val Phe Thr Glu Glu Arg Ala Arg Phe Tyr Gly
                245                 250                 255     
Ala Glu Ile Val Ser Ala Leu Glu Tyr Leu His Ser Arg Asp Val Val
            260                 265                 270         
Tyr Arg Asp Ile Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His
        275                 280                 285             
Ile Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Ser Asp Gly
    290                 295                 300                 
Ala Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu
305                 310                 315                 320 
Val Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu
                325                 330                 335     
Gly Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn
            340                 345                 350         
Gln Asp His Glu Arg Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg
        355                 360                 365             
Phe Pro Arg Thr Leu Ser Pro Glu Ala Lys Ser Leu Leu Ala Gly Leu
    370                 375                 380                 
Leu Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Pro Ser Asp Ala
385                 390                 395                 400 
Lys Glu Val Met Glu His Arg Phe Phe Leu Ser Ile Asn Trp Gln Asp
                405                 410                 415     
Val Val Gln Lys Lys Leu Leu Pro Pro Phe Lys Pro Gln Val Thr Ser
            420                 425                 430         
Glu Val Asp Thr Arg Tyr Phe Asp Asp Glu Phe Thr Ala Gln Ser Ile
        435                 440                 445             
Thr Ile Thr Pro Pro Asp Arg Tyr Asp Ser Leu Gly Leu Leu Glu Leu
    450                 455                 460                 
Asp Gln Arg Thr His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Ile Arg
465                 470                 475                 480 
Glu
    


<210> 21
<211> 147
<212> PRT
<213> Homo sapiens

<400> 21
Met Ser Gln Thr Arg Asp Leu Gln Gly Gly Lys Ala Phe Gly Leu Leu
 1               5                  10                  15      
Lys Ala Gln Gln Glu Glu Arg Leu Asp Glu Ile Asn Lys Gln Phe Leu
            20                  25                  30          
Asp Asp Pro Lys Tyr Ser Ser Asp Glu Asp Leu Pro Ser Lys Leu Glu
        35                  40                  45              
Gly Phe Lys Glu Lys Tyr Met Glu Phe Asp Leu Asn Gly Asn Gly Asp
    50                  55                  60                  
Ile Asp Ile Met Ser Leu Lys Arg Met Leu Glu Lys Leu Gly Val Pro
65                  70                  75                  80  
Lys Thr His Leu Glu Leu Lys Lys Leu Ile Gly Glu Val Ser Ser Gly
                85                  90                  95      
Ser Gly Glu Thr Phe Ser Tyr Pro Asp Phe Leu Arg Met Met Leu Gly
            100                 105                 110         
Lys Arg Ser Ala Ile Leu Lys Met Ile Leu Met Tyr Glu Glu Lys Ala
        115                 120                 125             
Arg Glu Lys Glu Lys Pro Thr Gly Pro Pro Ala Lys Lys Ala Ile Ser
    130                 135                 140                 
Glu Leu Pro
145         


<210> 22
<211> 292
<212> PRT
<213> Homo sapiens

<400> 22
Met Ala Ala Cys Ile Ala Ala Gly His Trp Ala Ala Met Gly Leu Gly
 1               5                  10                  15      
Arg Ser Phe Gln Ala Ala Arg Thr Leu Leu Pro Pro Pro Ala Ser Ile
            20                  25                  30          
Ala Cys Arg Val His Ala Gly Pro Val Arg Gln Gln Ser Thr Gly Pro
        35                  40                  45              
Ser Glu Pro Gly Ala Phe Gln Pro Pro Pro Lys Pro Val Ile Val Asp
    50                  55                  60                  
Lys His Arg Pro Val Glu Pro Glu Arg Arg Phe Leu Ser Pro Glu Phe
65                  70                  75                  80  
Ile Pro Arg Arg Gly Arg Thr Asp Pro Leu Lys Phe Gln Ile Glu Arg
                85                  90                  95      
Lys Asp Met Leu Glu Arg Arg Lys Val Leu His Ile Pro Glu Phe Tyr
            100                 105                 110         
Val Gly Ser Ile Leu Arg Val Thr Thr Ala Asp Pro Tyr Ala Ser Gly
        115                 120                 125             
Lys Ile Ser Gln Phe Leu Gly Ile Cys Ile Gln Arg Ser Gly Arg Gly
    130                 135                 140                 
Leu Gly Ala Thr Phe Ile Leu Arg Asn Val Ile Glu Gly Gln Gly Val
145                 150                 155                 160 
Glu Ile Cys Phe Glu Leu Tyr Asn Pro Arg Val Gln Glu Ile Gln Val
                165                 170                 175     
Val Lys Leu Glu Lys Arg Leu Asp Asp Ser Leu Leu Tyr Leu Arg Asp
            180                 185                 190         
Ala Leu Pro Glu Tyr Ser Thr Phe Asp Val Asn Met Lys Pro Val Val
        195                 200                 205             
Gln Glu Pro Asn Gln Lys Val Pro Val Asn Glu Leu Lys Val Lys Met
    210                 215                 220                 
Lys Pro Lys Pro Trp Ser Lys Arg Trp Glu Arg Pro Asn Phe Asn Ile
225                 230                 235                 240 
Lys Gly Ile Arg Phe Asp Leu Cys Leu Thr Glu Gln Gln Met Lys Glu
                245                 250                 255     
Ala Gln Lys Trp Asn Gln Pro Trp Leu Glu Phe Asp Met Met Arg Glu
            260                 265                 270         
Tyr Asp Thr Ser Lys Ile Glu Ala Ala Ile Trp Lys Glu Ile Glu Ala
        275                 280                 285             
Ser Lys Arg Ser
    290         


<210> 23
<211> 23
<212> PRT
<213> Homo sapiens

<400> 23
Met His Trp Glu Lys Val Asp Val Asn Asn Ser Ile Lys Gln Pro Tyr
 1               5                  10                  15      
Phe Leu Ile Lys Asn Asp Lys
            20              


<210> 24
<211> 226
<212> PRT
<213> Homo sapiens

<400> 24
Met Ser Arg Ile Tyr His Asp Gly Ala Leu Arg Asn Lys Ala Val Gln
 1               5                  10                  15      
Ser Val Arg Leu Pro Gly Ala Trp Asp Pro Ala Ala His Gln Gly Gly
            20                  25                  30          
Asn Gly Val Leu Leu Glu Gly Glu Leu Ile Asp Val Ser Arg His Ser
        35                  40                  45              
Ile Leu Asp Thr His Gly Arg Lys Glu Arg Tyr Tyr Val Leu Tyr Ile
    50                  55                  60                  
Arg Pro Ser His Ile His Arg Arg Lys Phe Asp Ala Lys Gly Asn Glu
65                  70                  75                  80  
Ile Glu Pro Asn Phe Ser Ala Thr Arg Lys Val Asn Thr Gly Phe Leu
                85                  90                  95      
Met Ser Ser Tyr Lys Val Glu Ala Lys Gly Asp Thr Asp Arg Leu Thr
            100                 105                 110         
Pro Glu Ala Leu Lys Gly Leu Val Asn Lys Pro Glu Leu Leu Ala Leu
        115                 120                 125             
Thr Glu Ser Leu Thr Pro Asp His Thr Val Ala Phe Trp Met Pro Glu
    130                 135                 140                 
Ser Glu Met Glu Val Met Glu Leu Glu Leu Gly Ala Gly Val Arg Leu
145                 150                 155                 160 
Lys Thr Arg Gly Asp Gly Pro Phe Leu Asp Ser Leu Ala Lys Leu Glu
                165                 170                 175     
Ala Gly Thr Val Thr Lys Cys Asn Phe Thr Gly Asp Gly Lys Thr Gly
            180                 185                 190         
Ala Ser Trp Thr Asp Asn Ile Met Ala Gln Lys Cys Ser Lys Gly Ala
        195                 200                 205             
Ala Ala Glu Ile Arg Glu Gln Gly Asp Gly Ala Glu Asp Glu Glu Trp
    210                 215                 220                 
Asp Asp
225     


<210> 25
<211> 154
<212> PRT
<213> Homo sapiens

<400> 25
Met Thr Thr Thr Thr Thr Phe Lys Gly Val Asp Pro Asn Ser Arg Asn
 1               5                  10                  15      
Ser Ser Arg Val Leu Arg Pro Pro Gly Gly Gly Ser Asn Phe Ser Leu
            20                  25                  30          
Gly Phe Asp Glu Pro Thr Glu Gln Pro Val Arg Lys Asn Lys Met Ala
        35                  40                  45              
Ser Asn Ile Phe Gly Thr Pro Glu Glu Asn Gln Ala Ser Trp Ala Lys
    50                  55                  60                  
Ser Ala Gly Ala Lys Ser Ser Gly Gly Arg Glu Asp Leu Glu Ser Ser
65                  70                  75                  80  
Gly Leu Gln Arg Arg Asn Ser Ser Glu Ala Ser Ser Gly Asp Phe Leu
                85                  90                  95      
Asp Leu Lys Gly Glu Gly Asp Ile His Glu Asn Val Asp Thr Asp Leu
            100                 105                 110         
Pro Gly Ser Leu Gly Gln Ser Glu Glu Lys Pro Val Pro Ala Ala Pro
        115                 120                 125             
Val Pro Ser Pro Val Ala Pro Ala Pro Val Pro Ser Arg Arg Asn Pro
    130                 135                 140                 
Pro Gly Gly Lys Ser Ser Leu Val Leu Gly
145                 150                 


<210> 26
<211> 695
<212> PRT
<213> Homo sapiens

<400> 26
Met Ala Ser Thr Arg Ser Ile Glu Leu Glu His Phe Glu Glu Arg Asp
 1               5                  10                  15      
Lys Arg Pro Arg Pro Gly Ser Arg Arg Gly Ala Pro Ser Ser Ser Gly
            20                  25                  30          
Gly Ser Ser Ser Ser Gly Pro Lys Gly Asn Gly Leu Ile Pro Ser Pro
        35                  40                  45              
Ala His Ser Ala His Cys Ser Phe Tyr Arg Thr Arg Thr Leu Gln Ala
    50                  55                  60                  
Leu Ser Ser Glu Lys Lys Ala Lys Lys Ala Arg Phe Tyr Arg Asn Gly
65                  70                  75                  80  
Asp Arg Tyr Phe Lys Gly Leu Val Phe Ala Ile Ser Ser Asp Arg Phe
                85                  90                  95      
Arg Ser Phe Asp Ala Leu Leu Ile Glu Leu Thr Arg Ser Leu Ser Asp
            100                 105                 110         
Asn Val Asn Leu Pro Gln Gly Val Arg Thr Ile Tyr Thr Ile Asp Gly
        115                 120                 125             
Ser Arg Lys Val Thr Ser Leu Asp Glu Leu Leu Glu Gly Glu Ser Tyr
    130                 135                 140                 
Val Cys Ala Ser Asn Glu Pro Phe Arg Lys Val Asp Tyr Thr Lys Asn
145                 150                 155                 160 
Ile Asn Pro Asn Trp Ser Val Asn Ile Lys Gly Gly Thr Ser Arg Ala
                165                 170                 175     
Leu Ala Ala Ala Ser Ser Val Lys Ser Glu Val Lys Glu Ser Lys Asp
            180                 185                 190         
Phe Ile Lys Pro Lys Leu Val Thr Val Ile Arg Ser Gly Val Lys Pro
        195                 200                 205             
Arg Lys Ala Val Arg Ile Leu Leu Asn Lys Lys Thr Ala His Ser Phe
    210                 215                 220                 
Glu Gln Val Leu Thr Asp Ile Thr Glu Ala Ile Lys Leu Asp Ser Gly
225                 230                 235                 240 
Val Val Lys Arg Leu Cys Thr Leu Asp Gly Lys Gln Val Thr Cys Leu
                245                 250                 255     
Gln Asp Phe Phe Gly Asp Asp Asp Val Phe Ile Ala Cys Gly Pro Glu
            260                 265                 270         
Lys Phe Arg Tyr Ala Gln Asp Asp Phe Val Leu Asp His Ser Glu Cys
        275                 280                 285             
Arg Val Leu Lys Ser Ser Tyr Ser Arg Ser Ser Ala Val Lys Tyr Ser
    290                 295                 300                 
Gly Ser Lys Ser Pro Gly Pro Ser Arg Arg Ser Lys Ser Pro Ala Ser
305                 310                 315                 320 
Val Asn Gly Thr Pro Ser Ser Gln Leu Ser Thr Pro Lys Ser Thr Lys
                325                 330                 335     
Ser Ser Ser Ser Ser Pro Thr Ser Pro Gly Ser Phe Arg Gly Leu Lys
            340                 345                 350         
Ile Ser Ala His Gly Arg Ser Ser Ser Asn Val Asn Gly Gly Pro Glu
        355                 360                 365             
Leu Asp Arg Cys Ile Ser Pro Glu Gly Val Asn Gly Asn Arg Cys Ser
    370                 375                 380                 
Glu Ser Ser Thr Leu Leu Glu Lys Tyr Lys Ile Gly Lys Val Ile Gly
385                 390                 395                 400 
Asp Gly Asn Phe Ala Val Val Lys Glu Cys Ile Asp Arg Ser Thr Gly
                405                 410                 415     
Lys Glu Phe Ala Leu Lys Ile Ile Asp Lys Ala Lys Cys Cys Gly Lys
            420                 425                 430         
Glu His Leu Ile Glu Asn Glu Val Ser Ile Leu Arg Arg Val Lys His
        435                 440                 445             
Pro Asn Ile Ile Met Leu Val Glu Glu Met Glu Thr Ala Thr Glu Leu
    450                 455                 460                 
Phe Leu Val Met Glu Leu Val Lys Gly Gly Asp Leu Phe Asp Ala Ile
465                 470                 475                 480 
Thr Ser Ser Thr Lys Tyr Thr Glu Arg Asp Gly Ser Ala Met Val Tyr
                485                 490                 495     
Asn Leu Ala Asn Ala Leu Arg Tyr Leu His Gly Leu Ser Ile Val His
            500                 505                 510         
Arg Asp Ile Lys Pro Glu Asn Leu Leu Val Cys Glu Tyr Pro Asp Gly
        515                 520                 525             
Thr Lys Ser Leu Lys Leu Gly Asp Phe Gly Leu Ala Thr Val Val Glu
    530                 535                 540                 
Gly Pro Leu Tyr Thr Val Cys Gly Thr Pro Thr Tyr Val Ala Pro Glu
545                 550                 555                 560 
Ile Ile Ala Glu Thr Gly Tyr Gly Leu Lys Val Asp Ile Trp Ala Ala
                565                 570                 575     
Gly Val Ile Thr Tyr Ile Leu Leu Cys Gly Phe Pro Pro Phe Arg Ser
            580                 585                 590         
Glu Asn Asn Leu Gln Glu Asp Leu Phe Asp Gln Ile Leu Ala Gly Lys
        595                 600                 605             
Leu Glu Phe Pro Ala Pro Tyr Trp Asp Asn Ile Thr Asp Ser Ala Lys
    610                 615                 620                 
Glu Leu Ile Ser Gln Met Leu Gln Val Asn Val Glu Ala Arg Cys Thr
625                 630                 635                 640 
Ala Gly Gln Ile Leu Ser His Pro Trp Val Ser Asp Asp Ala Ser Gln
                645                 650                 655     
Glu Asn Asn Met Gln Ala Glu Val Thr Gly Lys Leu Lys Gln His Phe
            660                 665                 670         
Asn Asn Ala Leu Pro Lys Gln Asn Ser Thr Thr Thr Gly Val Ser Val
        675                 680                 685             
Ile Met Phe Asp Leu Thr Val
    690                 695 


<210> 27
<211> 635
<212> PRT
<213> Homo sapiens

<400> 27
Met Ala Ser Ser Gly Met Ala Asp Ser Ala Asn His Leu Pro Phe Phe
 1               5                  10                  15      
Phe Gly Asn Ile Thr Arg Glu Glu Ala Glu Asp Tyr Leu Val Gln Gly
            20                  25                  30          
Gly Met Ser Asp Gly Leu Tyr Leu Leu Arg Gln Ser Arg Asn Tyr Leu
        35                  40                  45              
Gly Gly Phe Ala Leu Ser Val Ala His Gly Arg Lys Ala His His Tyr
    50                  55                  60                  
Thr Ile Glu Arg Glu Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Arg
65                  70                  75                  80  
Thr His Ala Ser Pro Ala Asp Leu Cys His Tyr His Ser Gln Glu Ser
                85                  90                  95      
Asp Gly Leu Val Cys Leu Leu Lys Lys Pro Phe Asn Arg Pro Gln Gly
            100                 105                 110         
Val Gln Pro Lys Thr Gly Pro Phe Glu Asp Leu Lys Glu Asn Leu Ile
        115                 120                 125             
Arg Glu Tyr Val Lys Gln Thr Trp Asn Leu Gln Gly Gln Ala Leu Glu
    130                 135                 140                 
Gln Ala Ile Ile Ser Gln Lys Pro Gln Leu Glu Lys Leu Ile Ala Thr
145                 150                 155                 160 
Thr Ala His Glu Lys Met Pro Trp Phe His Gly Lys Ile Ser Arg Glu
                165                 170                 175     
Glu Ser Glu Gln Ile Val Leu Ile Gly Ser Lys Thr Asn Gly Lys Phe
            180                 185                 190         
Leu Ile Arg Ala Arg Asp Asn Asn Gly Ser Tyr Ala Leu Cys Leu Leu
        195                 200                 205             
His Glu Gly Lys Val Leu His Tyr Arg Ile Asp Lys Asp Lys Thr Gly
    210                 215                 220                 
Lys Leu Ser Ile Pro Glu Gly Lys Lys Phe Asp Thr Leu Trp Gln Leu
225                 230                 235                 240 
Val Glu His Tyr Ser Tyr Lys Ala Asp Gly Leu Leu Arg Val Leu Thr
                245                 250                 255     
Val Pro Cys Gln Lys Ile Gly Thr Gln Gly Asn Val Asn Phe Gly Gly
            260                 265                 270         
Arg Pro Gln Leu Pro Gly Ser His Pro Ala Thr Trp Ser Ala Gly Gly
        275                 280                 285             
Ile Ile Ser Arg Ile Lys Ser Tyr Ser Phe Pro Lys Pro Gly His Arg
    290                 295                 300                 
Lys Ser Ser Pro Ala Gln Gly Asn Arg Gln Glu Ser Thr Val Ser Phe
305                 310                 315                 320 
Asn Pro Tyr Glu Pro Glu Leu Ala Pro Trp Ala Ala Asp Lys Gly Pro
                325                 330                 335     
Gln Arg Glu Ala Leu Pro Met Asp Thr Glu Val Tyr Glu Ser Pro Tyr
            340                 345                 350         
Ala Asp Pro Glu Glu Ile Arg Pro Lys Glu Val Tyr Leu Asp Arg Lys
        355                 360                 365             
Leu Leu Thr Leu Glu Asp Lys Glu Leu Gly Ser Gly Asn Phe Gly Thr
    370                 375                 380                 
Val Lys Lys Gly Tyr Tyr Gln Met Lys Lys Val Val Lys Thr Val Ala
385                 390                 395                 400 
Val Lys Ile Leu Lys Asn Glu Ala Asn Asp Pro Ala Leu Lys Asp Glu
                405                 410                 415     
Leu Leu Ala Glu Ala Asn Val Met Gln Gln Leu Asp Asn Pro Tyr Ile
            420                 425                 430         
Val Arg Met Ile Gly Ile Cys Glu Ala Glu Ser Trp Met Leu Val Met
        435                 440                 445             
Glu Met Ala Glu Leu Gly Pro Leu Asn Lys Tyr Leu Gln Gln Asn Arg
    450                 455                 460                 
His Val Lys Asp Lys Asn Ile Ile Glu Leu Val His Gln Val Ser Met
465                 470                 475                 480 
Gly Met Lys Tyr Leu Glu Glu Ser Asn Phe Val His Arg Asp Leu Ala
                485                 490                 495     
Ala Arg Asn Val Leu Leu Val Thr Gln His Tyr Ala Lys Ile Ser Asp
            500                 505                 510         
Phe Gly Leu Ser Lys Ala Leu Arg Ala Asp Glu Asn Tyr Tyr Lys Ala
        515                 520                 525             
Gln Thr His Gly Lys Trp Pro Val Lys Trp Tyr Ala Pro Glu Cys Ile
    530                 535                 540                 
Asn Tyr Tyr Lys Phe Ser Ser Lys Ser Asp Val Trp Ser Phe Gly Val
545                 550                 555                 560 
Leu Met Trp Glu Ala Phe Ser Tyr Gly Gln Lys Pro Tyr Arg Gly Met
                565                 570                 575     
Lys Gly Ser Glu Val Thr Ala Met Leu Glu Lys Gly Glu Arg Met Gly
            580                 585                 590         
Cys Pro Ala Gly Cys Pro Arg Glu Met Tyr Asp Leu Met Asn Leu Cys
        595                 600                 605             
Trp Thr Tyr Asp Val Glu Asn Arg Pro Gly Phe Ala Ala Val Glu Leu
    610                 615                 620                 
Arg Leu Arg Asn Tyr Tyr Tyr Asp Val Val Asn
625                 630                 635 


<210> 28
<211> 88
<212> PRT
<213> Homo sapiens

<400> 28
Met Asn Ala Ile His Thr Lys Glu Leu Leu Leu Thr Ser His Leu Gln
 1               5                  10                  15      
Ser Pro Pro Gly His Arg Gln Asp Pro Phe Asn Lys Ser Ser Ser Glu
            20                  25                  30          
Thr Pro Ile Val Gln Asn Leu Gln Leu Ala Thr Gly Tyr His His Ser
        35                  40                  45              
Leu Trp Leu Cys Lys Ile Lys Asp Leu Glu Glu Gly Trp Gly Gly Gly
    50                  55                  60                  
Ser Tyr Glu Lys Arg Gln Glu Lys Ser Ser Phe Asp Pro Met Leu Ser
65                  70                  75                  80  
Glu Ser Val His Glu Glu Glu Ser
                85              


<210> 29
<211> 79
<212> PRT
<213> Homo sapiens

<400> 29
Met Ser Glu Ile Leu Pro Tyr Ser Glu Asp Lys Met Gly Arg Phe Gly
 1               5                  10                  15      
Ala Asp Pro Glu Gly Ser Asp Leu Ser Phe Ser Cys Arg Leu Gln Asp
            20                  25                  30          
Thr Asn Ser Phe Phe Ala Gly Asn Gln Ala Lys Arg Pro Pro Lys Leu
        35                  40                  45              
Gly Gln Ile Gly Arg Ala Lys Arg Val Val Ile Glu Asp Asp Arg Ile
    50                  55                  60                  
Asp Asp Val Leu Lys Gly Met Gly Glu Lys Pro Pro Ser Gly Val
65                  70                  75                  


<210> 30
<211> 310
<212> PRT
<213> Homo sapiens

<400> 30
Met Gly Lys Arg Arg Cys Val Pro Pro Leu Glu Pro Lys Leu Ala Ala
 1               5                  10                  15      
Gly Cys Cys Gly Val Lys Lys Pro Lys Leu Ser Gly Ser Gly Thr His
            20                  25                  30          
Ser His Gly Asn Gln Ser Thr Thr Val Pro Gly Ser Ser Ser Gly Pro
        35                  40                  45              
Leu Gln Asn His Gln His Val Asp Ser Ser Ser Gly Arg Glu Asn Val
    50                  55                  60                  
Ser Asp Leu Thr Leu Gly Pro Gly Asn Ser Pro Ile Thr Arg Met Asn
65                  70                  75                  80  
Pro Ala Ser Gly Ala Leu Ser Pro Leu Pro Arg Pro Asn Gly Thr Ala
                85                  90                  95      
Asn Thr Thr Lys Asn Leu Val Val Thr Ala Glu Met Cys Cys Tyr Cys
            100                 105                 110         
Phe Asp Val Leu Tyr Cys His Leu Tyr Gly Phe Pro Gln Pro Arg Leu
        115                 120                 125             
Pro Arg Phe Thr Asn Asp Pro Tyr Pro Leu Phe Val Thr Trp Lys Thr
    130                 135                 140                 
Gly Arg Asp Lys Arg Leu Arg Gly Cys Ile Gly Thr Phe Ser Ala Met
145                 150                 155                 160 
Asn Leu His Ser Gly Leu Arg Glu Tyr Thr Leu Thr Ser Ala Leu Lys
                165                 170                 175     
Asp Ser Arg Phe Pro Pro Leu Thr Arg Glu Glu Leu Pro Lys Leu Phe
            180                 185                 190         
Cys Ser Val Ser Leu Leu Thr Asn Phe Glu Asp Ala Ser Asp Tyr Leu
        195                 200                 205             
Asp Trp Glu Val Gly Val His Gly Ile Arg Ile Glu Phe Ile Asn Glu
    210                 215                 220                 
Lys Gly Val Lys Arg Thr Ala Thr Tyr Leu Pro Glu Val Ala Lys Glu
225                 230                 235                 240 
Gln Asp Trp Asp Gln Ile Gln Thr Ile Asp Ser Leu Leu Arg Lys Gly
                245                 250                 255     
Gly Phe Lys Ala Pro Ile Thr Ser Glu Phe Arg Lys Thr Ile Lys Leu
            260                 265                 270         
Thr Arg Tyr Arg Ser Glu Lys Val Thr Ile Ser Tyr Ala Glu Tyr Ile
        275                 280                 285             
Ala Ser Arg Gln His Cys Phe Gln Asn Gly Thr Leu His Ala Pro Pro
    290                 295                 300                 
Leu Tyr Asn His Tyr Ser
305                 310 


<210> 31
<211> 147
<212> PRT
<213> Homo sapiens

<400> 31
Met Ala Ala Thr Thr Gly Ser Gly Val Lys Val Pro Arg Asn Phe Arg
 1               5                  10                  15      
Leu Leu Glu Glu Leu Glu Glu Gly Gln Lys Gly Val Gly Asp Gly Thr
            20                  25                  30          
Val Ser Trp Gly Leu Glu Asp Asp Glu Asp Met Thr Leu Thr Arg Trp
        35                  40                  45              
Thr Gly Met Ile Ile Gly Pro Pro Arg Thr Ile Tyr Glu Asn Arg Ile
    50                  55                  60                  
Tyr Ser Leu Lys Ile Glu Cys Gly Pro Lys Tyr Pro Glu Ala Pro Pro
65                  70                  75                  80  
Phe Val Arg Phe Val Thr Lys Ile Asn Met Asn Gly Val Asn Ser Ser
                85                  90                  95      
Asn Gly Val Val Asp Pro Arg Ala Ile Ser Val Leu Ala Lys Trp Gln
            100                 105                 110         
Asn Ser Tyr Ser Ile Lys Val Val Leu Gln Glu Leu Arg Arg Leu Met
        115                 120                 125             
Met Ser Lys Glu Asn Met Lys Leu Pro Gln Pro Pro Glu Gly Gln Cys
    130                 135                 140                 
Tyr Ser Asn
145         


<210> 32
<211> 256
<212> PRT
<213> Homo sapiens

<400> 32
Met Ala Ala Val Lys Ser Thr Glu Ala His Pro Ser Ser Asn Lys Asp
 1               5                  10                  15      
Pro Thr Gln Gly Gln Lys Ser Ala Leu Gln Gly Asn Ser Pro Asp Ser
            20                  25                  30          
Glu Ala Ser Arg Gln Arg Phe Arg Gln Phe Cys Tyr Gln Glu Val Thr
        35                  40                  45              
Gly Pro His Glu Ala Phe Ser Lys Leu Trp Glu Leu Cys Cys Gln Trp
    50                  55                  60                  
Leu Arg Pro Lys Thr His Ser Lys Glu Glu Ile Leu Glu Leu Leu Val
65                  70                  75                  80  
Leu Glu Gln Phe Leu Thr Ile Leu Pro Glu Glu Ile Gln Thr Trp Val
                85                  90                  95      
Arg Glu Gln His Pro Glu Asn Gly Glu Glu Ala Val Ala Leu Val Glu
            100                 105                 110         
Asp Val Gln Arg Ala Pro Gly Gln Gln Val Leu Asp Ser Glu Lys Asp
        115                 120                 125             
Leu Lys Val Leu Met Lys Glu Met Ala Pro Leu Gly Ala Thr Arg Glu
    130                 135                 140                 
Ser Leu Arg Ser Gln Trp Lys Gln Glu Val Gln Pro Glu Glu Pro Thr
145                 150                 155                 160 
Phe Lys Gly Ser Gln Ser Ser His Gln Arg Pro Gly Glu Gln Ser Glu
                165                 170                 175     
Ala Trp Leu Ala Pro Gln Ala Pro Arg Asn Leu Pro Gln Asn Thr Gly
            180                 185                 190         
Leu His Asp Gln Glu Thr Gly Ala Val Val Trp Thr Ala Gly Ser Gln
        195                 200                 205             
Gly Pro Ala Met Arg Asp Asn Arg Ala Val Ser Leu Cys Gln Gln Glu
    210                 215                 220                 
Trp Met Cys Pro Gly Pro Ala Gln Arg Ala Leu Tyr Arg Gly Ala Thr
225                 230                 235                 240 
Gln Arg Lys Asp Ser His Val Ser Leu Ala Thr Gly Ala Leu Gly Leu
                245                 250                 255     


<210> 33
<211> 70
<212> PRT
<213> Homo sapiens

<400> 33
Met Ser Glu Val Lys Ser Arg Lys Lys Ser Gly Pro Lys Gly Ala Pro
 1               5                  10                  15      
Ala Ala Glu Pro Gly Lys Arg Ser Glu Gly Gly Lys Thr Pro Val Ala
            20                  25                  30          
Arg Ser Ser Gly Gly Gly Gly Trp Ala Asp Pro Arg Thr Cys Leu Ser
        35                  40                  45              
Leu Leu Ser Leu Gly Thr Cys Leu Gly Leu Ala Cys Gly Arg Asn Leu
    50                  55                  60                  
Lys Leu Ser Trp Asn Asn
65                  70  


<210> 34
<211> 480
<212> PRT
<213> Homo sapiens

<400> 34
Met Ser Asp Val Ala Ile Val Lys Glu Gly Trp Leu His Lys Arg Gly
 1               5                  10                  15      
Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Asn Asp
            20                  25                  30          
Gly Thr Phe Ile Gly Tyr Lys Glu Arg Pro Gln Asp Val Asp Gln Arg
        35                  40                  45              
Glu Ala Pro Leu Asn Asn Phe Ser Val Ala Gln Cys Gln Leu Met Lys
    50                  55                  60                  
Thr Glu Arg Pro Arg Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp
65                  70                  75                  80  
Thr Thr Val Ile Glu Arg Thr Phe His Val Glu Thr Pro Glu Glu Arg
                85                  90                  95      
Glu Glu Trp Thr Thr Ala Ile Gln Thr Val Ala Asp Gly Leu Lys Lys
            100                 105                 110         
Gln Glu Glu Glu Glu Met Asp Phe Arg Ser Gly Ser Pro Ser Asp Asn
        115                 120                 125             
Ser Gly Ala Glu Glu Met Glu Val Ser Leu Ala Lys Pro Lys His Arg
    130                 135                 140                 
Val Thr Met Asn Glu Phe Glu Tyr Leu Lys Leu Leu Gly Lys Gly Thr
145                 150                 155                 160 
Phe Gly Lys Val Ile Leu Val Lys Glu Lys Ala Thr Gly Arg Tyr Tyr
                165                 170                 175     
Ala Met Lys Ile Leu Lys Lys Glu Val Ile Val Ala Lys Asp Glu Val
            180                 185                 190         
Ala His Thr Leu Thr Glu Asn Arg Val Leu Gln Asn Ser Arg His Pro
        195                 200                 205             
Phe Leu Thr Ala Leu Lys Tyr Ser Phe Gln Thr His Asp Arg Leu Cys
    210                 215                 220                 
Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His Leu Ser
225                 230                 235                 240 
Arg Glu Arg Val Phe Ser Glu Asp Arg Ala Arg Phe Tyr Gly Ala Glu
                245                 250                 255     
Ile Val Ser Ala Leu Asp Tyr Leu His Ser Glu Lys Asn Val Val Tyr
            260                 265                 270         
Arg Asp Leu Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile
        275                 280                 285             
Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Lys Asp Gly Ala
    290                 295                 300                 
Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val
305                 310                 315                 320 
Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly
                325                 330                 335     
Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln
            340                 345                 350         
Asp His Glu Lys Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg Phe
        355                 360                 365             
Pro Arg Thr Leu Gly Pro Glu Ala Lys Ser Leu Leu Ser Gly Leu Leu
    370                 375                 380                 
Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Ser Glu Asp Ala Lys
385                 390                 395                 400 
Glu Ile Met Gln His Arg Phe Phe Ala Gly Ile Val Trp Gln His Val
                405                 410                 415     
Tyr Glu Lys Lys Leu Ser Pro Pro Phe Lys Pro Gln Val Thr Ser Glu
            420                 425                 430         
Thr Asp Thr Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Met Ile Thr
        435                 440                 445             
Ile Thr Pro Pro Asp Gln Asp Asp Ser Met Glu Cys Val Asp Ser Glu
    450                 455                 460                 
Arg Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Gly Thr Ala
465                 470                 475                 480 


<210> 35
<211> 78
<212> PRT
<213> Homo sapiens

<400> 35
Met Ser Glu Val Leu Pro Tyr Gly Asp Glu Lys Leu Ser Pro Tyr Gly
 1               5                  10                  15      
Asp Gly Gly Asp Val Gly Gln Ile Phe Ser Cys Arg Leu Gln Asp Thr
            20                  25                  30          
Asn Asn Phe Phe Gly Ala Gly Gln Asn Lys Arg Pro Pro Lys Leu Gly
        35                  40                  45              
Gln Ile Gly Arg Ser Lys Arg Val Val Ile Glu Asp Asp Arg Ile Asp
    50                  55                  60                  
Asp Val Leu Lys Asn Met Thr Asp Lys Ala Pro Pro Gly Val
65                  70                  75              


<210> 36
<211> 885
<212> PRT
<213> Homo sapiens

<400> 36
Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys
 1               5                  10                  15      
Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala
            20                  25                  30          
Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg
        35                  40                  45              
Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro
    50                  55                  60                  
Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp
65                  70                  75                  80  
Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp
                85                  90                  95      
Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr
            100                 105                 110         
Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser
        115                 120                 125             
Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu
    130                 135                 140                 
Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys
145                 150                 155                 160 
Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp
                165                 170                 175     
Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu
            180                 185                 190         
His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His
        195                 200                 205             
Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu
    210                 215                 220                 
Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu
225                 230                 235                 240 
Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr
                245                 250                 255     
His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln
            260                 265                 270         
Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser
        275                 280                 285             
Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro
    290                 295                 300                 
Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp
305                 310                 315                 320 
Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro
                325                 330                 335     
Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His
            340                 345                 350         
Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg
        355                 360                 365             
Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly
    370                 375                 380                 
Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser
385                 390                 395                 400 
Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro
                405                 410                 415     
Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Val Lys Glu Pro
            420                 425                 430         
Ser Thr Pro Ala Phe Ser Trp Pro Trp Trp Tyr Val Leu Leu Gly Ala
        435                 440                 445             
Val Val Ala Ala Ala Cys Val Leu Ile Leu Ala Leu Phe Leu Val His
    450                 455                 460                 
Arg Arg Lys Lys Glu Thr Arg Tyr Gly Glu Val Phe Glu Pro Thr Val
465                 470                 475                 480 
Glu Arg Gly Glu Leu Val Val Arg Tyr Arg Val Arg Lys Ser Tyr Ser
                485                 490                 495     
Arg Arg Thr Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile Ser Glu Glu
            500                 505                 510         
Leu Lys Glu Lys Leu Arg Asp Val Met Val Asp Arg His Lys Val Ala
        515                 520                 525             
Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Ala Val Met Glu Gly
    530                 535                 540                 
Gln Leu Asn Gln Asp Asp Ser Ile Leu Lys Val Ala Val Lys Thr Met
545                 550                 555                 560 
Lys Ile Ala Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe Leu Ser Glu
                565                 570                 575     
Ala Val Cys Met Lys Glu Phe Asp His Pro Asn Val Met Arg Leu Ile
            580                 585                 590         
Gly Val Cys Phe Gln Gly Ser Glu Arg Glu Ser Phe Pro Ala Pro Val
        595                 600                 605             
Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His Ser Phe Leu Leu
    610                 615                 620                 
Tyr Ser Arg Leu Gly Asp Gln Pro Val Tyr Leu Pro Thr Gln Met Leu
625                 630                 635                 640 
Val Lys Phe Met Ala Asp Ile Ala Ser Gly Met Glu Tyr Leu Ser Thr
                645                 650                 655     
Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asn
            660                 665                 670         
Glu Asn Met Ser Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile
        675                 680                 685             
Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val
    690                 695                 700                 
Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys
705                 710                 715                 720 
Ser Asp Val Trp Ser Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg
                725                 730                 735     
Gly Gln Thr Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile Tyr Asp Tyr
            740                 745                 750         
Leu Arg Gln Gly Asn Arg Leu Lys Gln Pro Ala Asp Cys Leu Asp Gly
        755                 760                 765             
Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu Leu Asn Pro Gln Asp Arg
    770                 775                 780                 
Pro Ser Phe Thr Glu Leu Arg Glu Asp Leu Glu Asn Thr Leu Lys Ala
785                 790                 795                 800 
Leu Pro Pro Ala Gln Glu Pro Asp Glu Ile Leu Tyr Val Asn Met Asp
                805                 810                 815     
Glu Gly Gly Gly Tyr Pro Glu Pro Pro Gly Ala Ala Gly Gly Ala Asp
            820                 825                 830         
Pro Pro Thr Gln Pro Asp Pro Lys Asp Ser Cys Ser Cys Leu Thr Ala
        835                 840                 845             
Ala Glu Val His Pro Ala Gly Arg Tyr Val Leu Cys Pro Ser Thr Thr
    850                 855                 860                 
Pro Ser Pro Ala Gln Pro Ala Asp Arg Gly Ser Pro Ala Ala Pro Gly
865                 870                 875                 880 
Gln Glu Asp Gly Ala
                885 


<210> 37
<211> 403
<212> PRT
<213> Homo sapiens

<400> 37
Met Asp Arg Ser Lys Glu Asn Cys Ile Ser Gly Pro Val Lys Ala Thr
 1               5                  10                  15      
Ala Pro Val Gly Gly Pro Lys Arg Val Leu Val Thr Gln Gln Phe Pro
            20                  25                  30          
Cys Gln Asn Pro Leu Pro Val Asn Ser Gly Gln Ala Gln Arg Val Leu
        35                  40                  45              
Cys Pro Ser Asn Ser Ser Gln Arg Ile Pro Leu Gln Ala Gln Lys Leu
    50                  55                  60                  
Val Ser Ser His Lys Pro Val Gln Asn Gln Lys Gln Lys Gln Leu Gln
65                  70                  75                  80  
Ala Thr Ser Val Pro His Pro Val Ser Arg Pro Leu Asn Asn Thr Gln
                85                  90                  95      
Lys Ser Lys Gln Pro Leu Pro Ser Ala Pro Glu Asn Asn Pro Glu Glu
            100                 105                 110         
Glu Leu Ala Ser Lys Gln Lys Asn Glu Glu Ser Lys Lys Arg Gln Trp
        115                 120                 125             
Ala Leu Glu Asp Phe Glu Ile Gly Arg Pro Leu Gly Lys Gly Lys Phe
    130                 135                 140                 
Gly Asn Val Tyr Leu Ala Arg Glu Lys Gln Ser Lys Phe Ile Leu Ala
145                 150                 155                 160 
Leu Lys Val Leu Phe Lys Ala Gln Leu Glu Lys Ala Gly Val Glu His
                165                 170                 175     
Gln Leu Arg Arg Glu Val Glu Ile Gln Ser His Leu Arg His Pro Asn
            180                 185                 190         
Ile Leu Arg Leu Tyr Gly Tyr Phe His Asp Ala Thr Arg Val Tyr Leu
        195                 200                 205             
Ile Leu Glu Tyr Ala Pro Leu Gly Thr Val Tyr Arg Glu Leu Gln Lys
    210                 215                 220                 
Leu Ser Lys Phe Asp Glu Gln Arg Thr Ala Thr Tyr Ile Thr Glu Leu
225                 230                 235                 240 
Ala Asn Ala Leu Ser Tyr Cys His Ser Lys Arg Val Ile His Arg Asp
                245                 250                 255     
Ile Lys Pro Glu Asn Leu Leu Leu Gly Ser Ala Gly Glu Leu Lys Ile
            260                 265                 270         
Ala Asp Phe Gly Trp Ser Val His Ala Pro Ser Ser Arg Arg Thr Thr
        275                 280                 285             
Leu Cys Gly Thr Leu Asp Tyr Leu Pro Pro Glu Met Ile Glu Gly Arg
    290                 295                 300                 
Met His Asp Glu Lys Val Asp Leu Trp Ser Leu Gly Val Leu Cys Tyr
305                 310                 315                 320 
Glu Phe Leu Val Gly Lys Pro Pro Phe Glu Ala Asn Thr Tyr Gln Glu
                325                 330                 335     
Thr Tyr Lys Arg Ile Ser Arg Val Glu Phe Thr Phe Pro Asp Phe Val
            340                 345                 350         
Thr Glu Gly Ala Arg Asp Leu Ile Ser Arg Leu Leu Lys His Asn Pro
        355                 360                 365             
Ser Gln Arg Pro Met Leu Arg Glu Val Leu Glu His Pro Trp Ile Thr
    370                 375                 380                 
Ala Asn Ser Ser Lys Pro Ser Asn Cys Gln Asn Lys Glu Ser Ala Ser
385                 390                 395                 400 
Lys Gln Ser
            


<210> 38
<211> 976
<212> PRT
<213> Homo sapiens

<400> 38
Met Arg Gly Ala Arg Gly Ala Trp Asp Phe Leu Cys Val Leu Leu Leu
 1               5                  10                  15      
Leu Leu Arg Val Gln Thr Gly Ser Ser Gln Pro Ser Val Ser Pro Gly
            20                  25                  30          
Glu Pro Ser Pro Pro Ser Ile His Pro Gly Lys Ser Asp Leu Ile Val
        35                  40                  45              
Arg Val Gly Asp Glu Ile Arg Leu Leu Cys Thr Asp Pro Gly Phe Val
    50                  55                  60                  
Lys Trp Thr Phe Glu Ile Leu Asp Glu Thr Asn Glu Asn Lys Gln Asn
65                  70                  75                  80  
Glu Trp Ile Thr Glu Lys Ala Glu Ala Thr Asn Thr Gly Lys Tyr Thr
                85                  90                  95      
Cys Thr Asn Lys His Gly Leu Ser Asn Ser Ile Tyr Val Phe Val Arg
            100                 105                 110         
Asp Pro Ala Lys Leu Phe Leu Val Asp Arg Ser Leu Tyr Gly Lys Glu
        115                 120                 125             
Asp Asn Asp Thr Leu Val Arg Cys Pro Leu Thr Asp Pro Glu Val Thr
    130                 135                 140                 
Asn Tyr Ser Leu Lys Gly Cys Gln Gly Lys Pro Leu Pro Lys Asp Leu
145                 150                 155                 160 
Arg Phe Ile Pro Asp Pro Lys Ala Gly Ile Met Ile Lys Ser Val Lys
                165                 170                 175     
Arg Ala Tyr His Arg Leu Cys Leu His Cys Ser Val Asp Gln Glu Gly
            180                 185                 190         
Lys Ser Val Leu Ser Glu Lys Phe Ile Leu Lys Val Arg Pro Ala Phe
        195                 200                 205             
Lys Ala Val Pro Val Val Ser Val Ser Lys Ala Ser Tyr Leu Leu Arg
    210                 215                 220                 
Glu Gly Glu Glu Phe Thr Val Thr Cys Thr Ile Lys Asp Val Ser Ser
225                 230                 235                 240 
Ser Val Tyr Ser Thr Trp Lys Arg Glu Asn Ser Gln Thr Lys Leu Gln
                245                 250                 255     
Glu Lys Tyr Asn Ser Trp His His Gly Asp Phe Asn Tyr Glu Arg Gln
            260                 265                 270         
Ala Thr Leu Thr Ile Ser Ser Ala Arg Val Asn Asp Ser Gly Val Phe
        275                 280                 285             
Met Cys Tyr Ala Asn Asn Thr Phe Gly Ser Ala Asn Val Thr Thr Thr
    290                 295                 300                 
Leu Glu Val Val Asp Lys Gly Phe Ile Asn Ile Phe Pro Met Ile Asn
305                 310                 315                 320 
Thr Thr Val Phe Val Asn Asp Gly Glu Asn Val Asp Leu Ile Val Glu
                325                 330                 335     
Tyr Glu Ala Phe Pro Lys Pro Glu His Gln Gln Trp Ile Tyr Met Asn
            340                 345                 350         
Arg Thr Phe Thr Asp Lys Trp Glu Asp Tyr Pro Lys Ser Glu Asn Glu
        355                 360                 365             
Ser Asn Ile Arg Tyr Val Ser Glu Leu His Leu Thr Arg Leu Lys Gly
    370                 375                 380                 
Thr Glu Gly Gly Thr Tyr Thr Phe Leu Val Ser Asn Ser Asp Val Asn
385                 390                 395                 400 
Ala Ala Ile Ala Phe Asn Val Tyr Val Asn Thr Lys Pro Glu Ile Leu
                405                 410                 415     
Thr Tyr Asp Arg Leu Val Asn Gly Met Leu Gln Cys Val Ala Ala Gly
            420                 425                 430         
Phe Pro Glu Pro Thr Ile Asp Trp Tyr Phe Cys Pro Gly Thr Glu Gln
        435                 440                 445             
Arg Cys Ser Ala Ser Val Leu Pro Val Asp Val Gln Thr Leu Asn Ser
    450                 455                 460                 
Ser Gly Pro Pro Phe Gly Lys Leu Val Val Gln Ser Ser Ile Asp Ser
465                 470                 475                 480 
Ser Ala Phe Lys His Asn Gly Thr Val Glu Cys Lys Ala Tyr Asn Asp
                485                 490                 495     
Val Gly Lys Thr Ser Ala Tyr Phe Asn Phe Ala Phe Lys Gly Asn Asn
            500                 505                 510         
Lys Glu Gln Ile His Pro His Thr Leu Phe Thr Pro Leu Leu Ile Gly
        515                 520                 525             
Phe Val Ile Val Ala Gly Met Met Cys Ile Ile Val Met Ile Leu Thr
    530                 535                 540                 
Tyr Lys Tyr Leu Gln Lys Pro Met Tyr Glu Val Gln Trp Lys Val Val
545                 550                 555                 560 
Glu Glu Ile Asn Gly Asn Asn Tyr Val Tyr Ile Asp Pro Thr Gln Leu
                565                 570                 575     
Pro Tyr Asp His Lys Trp Glu Phe Pro Arg Asn Arg Leu Ser Phe Gly
            580                 585                 590         
Lys Thr Leu Gly Ala Gly Ala Phe Gly Lys Val Val Glu Ala Thr Ala
        595                 600                 605             
Tyr Gly Leu Ile Lys Ser Asp Ala Ala Met Thr Val Ala Val Lys Met
    610                 615                 620                 
Leu Lys Pro Ser Ala His Leu Thr Glu Arg Glu Ala Leu Met Ser Glu
625                 630                 635                 640 
Leu Lys Val Leu Ser Tyr Leu Gly Asn His Met Asn Ile Val Asn Leu
                645                 650                 655     
Leu Gly Ala Cys Thr Ile Gly Gly Pro Thr Leu Val Ile Thr Glu Tyr
            660                 665                 670         
Cys Cys Tyr Gly Asp Leu Leu Asn Phe Leu Arg Arg Lys Arg Asp Ser
        675                 680                 685             
Phe Ile Cys Ser Lys Gln Glu Asp His Ala Glu Ala Ala Leu Tyr Lys
    690                 695                 700                 
Asn Leu Leu His Ser Lys Glu Ser Ser Cys Ser Asp Ser Thr Asn Glu
705                 710                 715                 720 
Tyr Met Asp Met Lys Pro Gly Val Ser Tyr Val Val Pro Thr Lys Ala
                725                 730                 735     
Asp Lys Arg Arg Ser Val Arg Ile Gly Ser Tyr Ile Glu Arg Asp Val
            740                 745                 750         
Thr Pro Ala Ile Met Glu Asp Asp Glu Leu Ala Leu Asp Leu Glu Asp
        755                 760                 765             
Leu Leu Ser Phe Ser Tyr Gln Val Ala Lys Gly Met Ala Phe Leu Ala
    770                 775                 780                 
Ser Lys Asn Cys Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu
785                 790                 795                 800 
Thr His Gly Arg Ile Thr Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp
                805                 810                 815     
Ile Lys Asn Asp Ser Asn Tyr Val Val Lys Gly Asn Ala Arg Leu Pro
            820                 825                 830         
Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Cys Val Tyr Thr Phe
        835                 840                 845             
Glu Ser Asp Val Trp Ser Tyr Gly Ile Phe Leu Trp Glu Leu Phe Ser
    850                 855                 860                 
Leu Gly Ser Ser Pro Tyr Pro Gly Met Pro Val Asp Ser Lys Phe Tyr
865                 870                 875                 880 
Lys Met Ile Lys Glu Gly Phe Arg Met Leu Ser Pro Glu His Ala Pro
                885                 890                 895     
Ala Glu Met Tyr Asp Ile Met Lys Thr Cys Trp Asp Ala Asp Pro Leu
            900                 905                 910         
Lys Arg Pro Thr Phe Lys Gln Ile Val Gln Leu Ile Glu Lys Gln Ile
        915                 920                 925             
Ser Glu Ser Thr Asn His Ile Tyr Ser Asn Leu Ala Asn Cys Ser Pro
    930                 935                 940                 
Asn Arg Gln Lys Pro Val Val Asp His Ser Val Arg Ile Asn Ser Val
945                 950                 955                 960 
Gly Ser Thr Ala Ser Ser Ser Gln Pro Leu Leu Val His Asp Asp Val
                965                 970                 975     


<210> 39
<211> 422
<212> PRT
<213> Homo sapiens

<400> 39
Met Asp His Pro Ser Arg Glu Lys Asp Glu Arg Gln Arg Thr Thr Lys
 1               5                  10                  15      
Pro Met Ala Gln Arg Ser Ala His Cys Ser Arg Pro Ser Gly Ser Ser
            20                  25                  30          
Ser Ser Ser Gly Val Leu Met Val Gly Pro Asn Phe Arg Val Gly Lys
        35                  40                  45              
Lys Ile Gly Cys Gly Asn Phe Gly Glu Leu Arg Leu Gly Lys Asn Leu
    50                  55                  60                  
Tyr Thr Asn Glu Tyr Val Ala Ile Lys Leu Glu Pro Ile Lys Ser Arg
65                  70                  75                  80  
Ala Pro Gln Leu His Leu Glu Tyr Arg Phe Tyr Lys Gln Leu Gly Ser
                85                  90                  95      
Ala Gly Glu Gly Leu Pro Gln Val Tyr Tyr Phe Gly Pro Cys Gly Lys
            100                 105                 110         
Tyr Asn Ala Met Val Leu Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu
        115                 120                 125             
Phe Asp Leu Cys Asp Arg Thr Phe Thr Leu Lys Thr Val Leu Met Ile
    130                 135                 140                 
Ala Ile Gln Leu Leu Ser Arg Met Glu Tyr Val His Ser Lys Asn Leu
145                 150                 155                 160 
Ile Tyr Arg Asp Val Lys Pro Glu Asn Phe Leu Ile Gly Arg Gln Gly
                165                 170                 175     
Asn Lys Lys Glu His Val Ile His Ile Ile Asp Phe Gly Leu Ala Lys
            180                 185                 190         
Glu Tyr Ile Asp Pro Glu Thr Lys Lys His Ile Pro Tyr Arg Glu His
        195                 200                 205             
Lys Ser Leu Thr Gly Thr Ala Arg Tyr Met Ser Ile Asn Thr His Leu
    210                 215                 220                 
Gly Lys Glu Gln Ser Arg Arg Asp Asp Leu Glu Ala Leu Gly His Met
225                 230                 235                 240 
Phe Met Tyr Phe Leu Arg Gly Ser Leu Pro Trp Gln Gly Leu Lys Ala
                245                 250                 255     
Asp Thr Leu Lys Glu Arg Tyr Gln Lys Ile Gly Asp Thr Lys Arg Asn
            260                 265                 270         
Thr Pro Ile Glu Ala Leu Cys Glu Asn Phe Pro Glu Glu Met Ala Thr
        275                 280                 285             
Tyr Leu Arg Tyr Val Arg Arg Leu Asp Phe Phe Glu Lys Pro Asp Tyr
    290                 295                 300                 
Glu Tyr Leu Arg Thr Leu Phe Thr Asp Leu Phe Glu Lys Lys Gly Tyr
305                 310                 315                 320 
Thr Phe Asp Tyr Ala Tyr Asp Trp Val Gly Arg Pro Ile Pro Thr Pro
                325                 330                 335     
Val Gly Ser Val His Val Asp Ser Gly Ala Ser Ala Ile Thr Arg Glu
            340                 345                 350         
Ser His Thr His Arg Asp Arg Pro Ser Gln Gln Gln Pro Leu Arg Asn
        355                 360                 365             
Gln Val Val Ser Ser Thr Asn Gly Glu Leu Asn Val Asp Asp Pro Thr
    370                 375                 380                 
Gly Ala His Ser Asn Ala Pro Ile Thr Ala His Ala Glu Val Glu Val
385                 390                 395                 400 
Val Glu Glu Ala Lys Cys Cys Cys Phe Phe Lys Arg Lys Arg Lys Lys
                405                 410                 415     
Thr Ala Gln Arg His Lys
            420         


<210> 40
<211> 416
<212> PRT
<213> Homo sapiens

<400> 40
Met Glu Leu Arg Val Gly Asn Lys Tyr Arg Leu Gly Arg Lys Ile Gly
 1               5                  10                  15      
Ser Gly Ser Phe Gly Asp Ile Tyr Leu Gly Ala Asn Ile Ala Ser Gly
            20                  25                  30          
Glu Glu Val Ala Ile Lys Leu Glu Cys Val Lys Thr Lys His Pro Gln
        35                  40                  45              
Leu His Ile Glu Ser Lys Phe Tyr Lys Met Met Gln Gly Gly Val Gly
    50                  55                  60                  
Ile Pro Ser Ile Lys Trp Cys Gly Ala Glu Gly Asp Tyr Asn Val Met
65                  70                  75                  80  
Val Met Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu Phe Asn Phe Cys
                85                  90                  95      
Ser Arg Lys Phe Ser Leu Lys Thr Val Leu Leu Leu Ala Asp Gln Met
            100                 105                 110         
Ile Ser Arg Ile Glu Tyr Ile His Ser Lys Asn Phe Ile His Arg Asp
        115                 120                 125             
Val Lys Pro Asp Asn Phe Leu Met Gly Leu Gly Lys Lys Gly Asn Leu
    130                 135                 140                 
Val Tyr Ile Ile Asp Phe Gly Leu Ala Lys Lys Tyr Arg Asp Ala Arg
145                 150                 155                 160 
Thr His Gln His Ile Pro Tyr Arg Glu Asn Lys Asn Leu Thr Gly Thr
                165                 170                 175     
Ala Arg Tyr Ala Ser Ile Asn Thr His Leu Gly Ile Glu Gln Ser Arg
            180                 185                 190         
Arg Asp Asp Leu Glu Ser Leu Gly Tyr Val Leu Met Tyr Phe Asn Leu
        195                 200                 205             
Gly Ser Leu Pro Trp Gln Gly Leu Lys Ala Ala Thr Lys Arg Gln Lys
    210                 215                 220                 
Tyr Glu Arg Ile Ser Glu Lys Lys Met Ser Thr Pro Ile Glu Val Leu
225                 230                 235                 240 
Cys Lys Gly Tyr Pro Ser Glu Phe Ser Thr Tyr Leu Asn Phe Cys Arg
                245                 250                 255     
Ser Leu Arg Phe Asp Asp Lys Pro Asp Tyr Ser Tyr Leu Arg Gln Leu
            260                 265                 270         
Phe Arg Asn Leu Phe His Arg Gln Gly Phe Ser Tyr Asp Tyr Val Phe
        275                 280                 285             
Asp Trp Asn Met Leu Lys Phe Gly Ala Ala Arg Asn Pro Glu Asp Val
    290                 295                 300                 
Asp Arg Glu Arg Arg Glu His Glu Arg Glu Glu Arg Met Gly Gln Leu
305                 310                 315                 320 
Arg Gly Ser Ala Thr Arg Ala Leu Pro Pro Gly Pro Pro Thr Gly Ala
                325                 330                 335     
Thr Ala Asn Arg Leu Arg Ser Ala Ala Glu Pro Val Ala Ser Thr Pro
            340                 345                 350         
Ala Ser Arg Ile Gln Pro Ala Gly Asn Thr Ser Pro Arg Ala Ile Ser
        355                 360                 365             
Arg Val Asp Arg Glu Arg Lys Val Ser Met Arg Leu His Arg Gly Ala
    370                 375                 380                 
Pro Ala Asn Val Ser Ser Ser Asp Leu Thr Gly Arg Gln Glu Val Ser
385                 390                 395                 400 
Arg Ile Pro Ala Ser Gln Thr Ser Val Pro Phe Asp His Leu Gly Lys
                405                 410                 415     


<210> 41
<211> 726
<212> PRT
<213> Homo sapiens

<400> 41
Met Glu Gly Glu Arg Lys Asn Asn Asn Lys Arg Trp Tyr Phe Thr Arg
 1               5                  10                  15      
Glu Gln Leu Glu Asn Ser Pro Ser Arg Arg Phe Gly Val Asp Pro Asp
            20                  25                  30          
Lys Glu Leu Ser Tyr Arg Gln Gln Ala Ala Asn Leu Leu Gln Asp Met
        35                  40                  45              
Gly Gln Arg Leu Asn Val Ser Gln Leu Thr Ile Asn Thr Ala Ile Val
    50                  55                  60                  
Tyr Met His Arg Phe Tyr Met Ile Gln Ser Phe Thr Gln Phe Pro Gly
65                  70                  75                  80  
Asn Ser Val Ala Pro Ala Ala Leu Phe Leu Ala Ala Lys Val Glu Glu
                85                  90                  95      
Gln Pro Lys Lys Leu Glu His Val Ile Lys Val Ala His Thr Cys Leu
            100                 105                 110         
His Pro Gln Glu Ser Leu Pro Asp Thr Arg Ser Glu Ala Tyr Leu Gln
        115                 120                 125             
Gln Val Gln Asp Leu Val Ile Leu Glu Ser Ile Ile Leu Gln Thr Leu
    130                 135                 140                 
Gly Phe Glu Leu Thr Ile Asp His Pro His Thr His Val Val Lys Cys
145                 150                 155                 160 
Thr Gln Leu Val Arg Ala Ser Lys Asp Leu Ala Gln Thr Ser Tyr Phe
                165                 170                 175     
Met Ala Thr Asn Ser Leu His Leu Thr Thr Phe Ser Leu Gln Tyr Thr
            180                 185                 190         
Pro Pro Val Val Ala Cys Val Cys Ile His Leu Ala Cys Lys Trp Ser
        195                 200                 205             
Asn Trp Glu Ile Pro Val Ser Thr Asp Gly Lys His Trp Trp Glu Tyr
    210                 215                 220                 
Val Asp Ala Thr Val Thr Leu Glu Leu Leu Asp Glu Leu Thr His Glu
225                 230                 235                 240 
Phe Leu Gln Ile Leu Glu Lys Thr Pro Asn Arg Leu Lys Arg Ile Trp
                245                 250                 255     
Asn Trp Arg Ala Cys Glu Ala Ala Lys Lys Thr Lys Ala Asp Asp Arg
            260                 265                 270         
Gly Thr Asp Glu Lys Thr Ser Glu Gln Thr Ile Leu Asn Met Ile Ser
        275                 280                 285             
Gln Ser Ser Ser Asp Thr Thr Ile Ala Gly Leu Met Ser Met Ser Thr
    290                 295                 300                 
Ser Thr Thr Ser Ala Val Pro Ser Leu Pro Val Ser Glu Glu Ser Ser
305                 310                 315                 320 
Ser Asn Leu Thr Ser Val Glu Met Leu Pro Gly Lys Arg Trp Leu Ser
                325                 330                 335     
Ser Gln Pro Ser Phe Lys Leu Glu Pro Thr Gln Gly His Arg Thr Ser
            340                 345                 350         
Glu Asn Leu Ala Leu Thr Gly Val Asp His Ser Leu Pro Gln Asp Gly
        355                 360                 365             
Ser Asn Ala Phe Ile Ser Gln Lys Gln Asn Ser Lys Ser Val Pro Ser
    370                 375                 380                 
Ala Lys Val Ser Leu Lys Glu Tyr Arg Ala Lys His Ala Glu Glu Leu
385                 390                 395                 400 
Ala Ala Gln Lys Arg Gln Leu Glu Asn Met Glu Ala Asn Val Lys Ser
                405                 410                 415     
Gln Tyr Ala Tyr Ala Ala Gln Asn Leu Leu Ser His His Asp Ser His
            420                 425                 430         
Ser Ser Val Ile Leu Lys Met Pro Ile Glu Gly Ser Glu Asn Pro Glu
        435                 440                 445             
Arg Pro Phe Leu Glu Lys Ala Asp Lys Thr Ala Leu Lys Met Arg Ile
    450                 455                 460                 
Pro Val Ala Gly Gly Asp Lys Ala Ala Ser Ser Lys Pro Glu Glu Ile
465                 470                 475                 480 
Lys Met Arg Ile Lys Val His Ala Ala Ala Asp Lys His Asn Ser Val
                485                 490                 495     
Glu Asp Ser Val Thr Lys Ser Arg Glu His Lys Glu Lys His Lys Thr
            500                 505                 510         
His Pro Ser Asn His His His His His Asn His His Ser His Lys His
        515                 520                 525             
Ser His Ser Gln Leu Pro Val Gly Thr Gly Asn Lys Arg Pro Gly Asp
    530                 535                 540                 
Pro Lys His Ser Ser Gln Thr Ser Asn Leu Ala His Lys Thr Tyr Ser
545                 550                 555                 560 
Leu Ser Ser Ser Phe Ser Ser Ser Ser Ser Thr Arg Lys Arg Gly Pro
                565                 570                 575     
Ser Glu Glu Thr Gly Gly Ala Val Phe Asp His Pro Ala Lys Ile Ala
            580                 585                 590         
Lys Ser Thr Lys Ser Ser Ser Leu Asn Phe Ser Phe Pro Ser Leu Pro
        595                 600                 605             
Thr Met Gly Gln Met Pro Gly His Ser Ser Asp Thr Ser Gly Leu Ser
    610                 615                 620                 
Phe Ser Gln Pro Ser Cys Lys Thr Arg Val Pro His Ser Lys Leu Asp
625                 630                 635                 640 
Lys Gly Pro Thr Gly Ala Asn Gly His Asn Thr Thr Gln Thr Ile Asp
                645                 650                 655     
Tyr Gln Asp Thr Val Asn Met Leu His Ser Leu Leu Ser Ala Gln Gly
            660                 665                 670         
Val Gln Pro Thr Gln Pro Thr Ala Phe Glu Phe Val Arg Pro Tyr Ser
        675                 680                 685             
Asp Tyr Leu Asn Pro Arg Ser Gly Gly Ile Ser Ser Arg Ser Gly Asn
    690                 695                 700                 
Thr Asp Lys Pro Arg Pro Pro Pro Leu Pro Ser Glu Pro Pro Pro Pro
705                 710                 715                 720 
Leu Pro Pro Leu Pro Lys
                725     


<210> 42
<211> 591
<212> PRT
<213> Homo sapiens

<400> 42
Met Phe Gly Lys Arg Lys Lys Arg Val Glu Ile Ser Ala Pro Ser Asn
 1               5                  10                  15      
Phe Glu His Arg Val His Thr Gly Phe Asp Gln His Glu Gln Lys Phe
            20                  25                  30          
Thr Gly Leu Pro Arg Gln Trp Gln Ser Leu Ile Glu Glu Ser Ala Arg
        35                  40                  45              
Arg Pro Lys Pro Leu Val Asp Pro Ala Cys Ile Thr Ser Ile Gln Pro
    50                  55                  60                  
Gly Ala Pro Lys Thr Ile Val Arg Gly Ser Lys Gly Ala Lys Asp Gly
65                  70                  75                  80  
Ala Leu Thr Leu Leu Leu Asp Glu Phe Glu Asn Met Ser Val Thr Arg
                85                  90                  95      
Ser Asn Ser Leu Arg Arg Asp Ser Pro Pro Pro Pro Ala Arg Ala Arg
            100                 105                 110         
Gln Glu Asn Gly Met Pro Glu Glu Pro Ala Thr Thr Ala Arg Gly Gly
        115                 120                 125             
Pro Gly Lys Ala Gly Ser Arg Gly Arg Phe Ala Gly His Ser Glu Ala
    130                 135                 140                 
Gly Gly Gly Ser Gly Asp Arg Arg Arg Ala Gly Pro Glu Lys Arg Pro
145                 150                 155                 160 
Lys Ser Ser Arg Glu Gly Ser Gly Gly Pro Gln Glu Ser Ser Arg Asp
                165                 170                 175     
Lys Arg Pro Leu Ser Gly Pro Asp Val Gly Thr Pro Gln Pro Ala Gly
            180                 185                 190         
Leu Ala Ser Gly Ala Lys Leu Ala Ala Gly Arg Pro Phe Asn Thr Tyr
        195                 200                 205             
Pro Arg Ala Asp Thr Asp His Pro Ser Arg Gly Ala Gln Gly Glu Pro
    210                 215                 220                 
His Asp Val Ala Pro Asn Gly Pro Ser Ala Gly Gly Leu Ala Ile Pro
225                 230                 235                 240 
Gln Ser Ser Ser Ser Ser Ser Arg Pro Pro Thr Arg Ala Arg Gly Ala
                245                 250                 255     
Pro Ser Pro Gly Val Leu Gly Pro His Ala Ser Glu Pro Gln Leu Ala
            260                 265                 270         
Pro Pro Ala Cys Thr Pro Ala Ala Pro Ala Val Pro Gly Pro Pro Gly
        275                 280                 285             
Pro Arg Ser Pro Gln Arg Glu Pro Gln Arg Val Ser His Glu Gln Phe
    290                 295                 300                 
Arg Ala Ala Leu Gln Leu Val Val Asp Pro Gly Asp Pro Arg Ser Tyr
305                 310                 315                 320 
Leu Asp Asn Phe Ile Lys Ile Gly Glu Gly Ser Thr Gly Ile Val Cys
                325                 330                 335     
Ile Ala Thr Val Arg Ser Ser Gly Lys Leu Val Ala Val Lys Lys Met
            340                 345                 350         
Asp Leu Arg Lys Gln Gln Arg Arg Glu Leu Leu Phe Asn Glu Val Val
        355                 360                 365             
Ile Met Arg Asp Tyr Gln His Glu Asn Val Val Glu Met Tyr Asn Ser
    370                 375                 380                 
Tyr Leu Val Gly Asp Glu Leu Trp Val Val Met Glu Phe Leu Glu Gly
385                 390                 395                 400 
Gly Ala Leu Thr Asp Ile Val Thr His Thr Arg Met Asn Glu Glu Gln
                405                 410                 415     
Ile Ala Ala Val Cys Leu Ala Val Leu Gln Ala Leu Ser Val Leu His
            420                 425                 430         
Ala Gln Gly Val Ile His Arg Asp Ile Lys Ser Asp Ser Ile Leu Leu
        435                 440                 445             
Thr His Asp Gly Arg Val Lys Leu Ser Asp Phe Gly Phe Cys Ala Gln
    450                 455                 460                 
Val Ser Lys Glu Val Pro Arg Arg Lys Ser Leu Val Gly Thr Pro Tyr
465                 470                 475                 480 
Trp Met Ala Pro Glu Leu Ile Ser Arg Leu Pro Tyr Gly Pro Glu Val
                485                 490                 495     
Asp Ile Trp Ser Leu Gly Ile Met Val Ile Glu Met Val Asp Gly Glu
            500                 505                 510         
Pro Pro Tyr Phe Asn Glu Pro Pro Leu Lys Ala Met Lys Met Ile Arg
        515                 520                 525             
Asp Asn Leu Pro Pro Arg Leu Lys Asn Leu His Lys Val Ser Pro Ser
    530                 535                 540                 
Leu Lys Gly Phe Leu Asp Arg Leu Leu Val Arg Asp Pro Ala Gln Arg
545                 550                 555                 560 
Ala Thr Ala Ala Glu Leu Leu Lys His Pro Phe Leu Ala Lys Ala Gly
                565                 570                 575     
Pro Pro Ala Ser Ile Val Pro Leu Met Arg Gln Asn Arg Thr Arg
            580                 585                 590     


<210> 43
<211> 424
<212> PRT
<213> Homo sapiens

<400> 43
Met Ser Asp Ser Lys Cys Asp Ser Gln Phe Tyr Ser Val Gln Val Ala
 1               5                  10                  15      
Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Gln Leu Lys Pro Ile
            20                  25                  30          
Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Phe Asp Thr Val Leu
        35                  40                  45              
Gly Ile Asn Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln
    50                  55                  60                  
Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Leu Lys Cys Val
65                  70                  75                  80  
Asn His Lys Asn Ile Ile Ser Leu Leu Asn Val Phe Thr Pro Gln Lys
                85                  90                  95      
Thr Leu Glu Glu Phe Gln Asp Val Tyr Leu Val Met Glu Leu Met Asp
            100                 105                 110         
Ala Asn Leu Cys Gln Val Ile His Met Glu Leu Asp His Glu Arg Met
        115                 120                 125             
Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser
    130                 135                 140                 
Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys
145                 150                 155                 160 
Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala
                165                 170                 175     
Cys Thr Asn Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg
            180                 185                 190         
Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Ile
        195                 200                 205             
Trp Ser Val Gly Cys Ile Met Gly Glu Leu Val Lys Gly Cys Val Ile
    210                 215                 220                 
Phe Gln Gly Thr Asp His Ile Asp Gln Trp Asn Lys Val Ile Glu Gln
225                 230                 235                 240 
Leu Gly Thr Pro Ser Ala Glu Phe Met Lys Lys Leu Gln Pro Thr Val
                245                 250                 255     
Arg Asn Tyr Val Glu Asn Arg Pro Lys Tyr Pro Gly Ile Lys Phe Glu
            260                 265                 270         
Glu Leu Phe Pro Asp Trp Ile Phe Pro Ser Glu Ser Glu Arg Asp Lys
        275                 280                 285             
Ile Lys Thr Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile
    290                 295                 300                 
Asp Pro Asp Lys Arg Ile Ser Val Asp Glu Ala Leu Arg His Pro Tyr
305                 310                 315                 320 
Ile Thr Val Trp Tyr Asp Pro Ala Glu Ala Glu Ala Pro Pro Pro Gln
                325                 330                 335     
Ile Tyr Asp Ala Gln Leu Glu Glu Arg Glu His Ala Ile Glu Glu Trp
            340                 345                 350         
Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Trp Glu Glu Arg Ser Lys
        355                 360                 365             
Asn Gly Val Val Lys Asp Gln Pro Ser Asp Ala Ala Val Ser Ser Asn
    370                 375                 380                 
Ala Thr Pro Ser Gln Ser Ser Ser Ile Asn Asp Ile Ser Ser Met Ser
385                 390                 395                 400 
Thr Glu Gln Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu Asp Ala Ser
                405                 410                 415     
Thr Gly Pro Leu Glu Gly Cys Arg
            420                 


<210> 44
<211> 209
<212> PRT
<213> Homo sapiens

<400> 44
Met Lys Phe Lys Leu His Val Asn Ser Ala Arg Gln Tyr Lys Asp Leu
 1               5                  10                  15      
Trp Asn Met Ser Asp Asp Lys Pro Phe Leu Cys Thr Ala Pro Gly Cys
            20                  25                  30          
Gly Gln Arg Phe Thr Asn Glu Asp His Leu Ala Val His Lys His Lys
        35                  40                  45              
His Glu Met Thr Leu Lys Phe Gly Pro Ala Arg Asn Asp Ser Val Ile
    50                  55                  60                  
Val Ala Asp Gln Thr Pro Thr Pro Thr Arg Phe Leu Lys Asn Cys Glu
65                  70                  75                  80  
Glu Val Gly Leu Phe Asn Glu Leu Ala Ser Pro Phe Glu Asn Glu Phe
                85                  90                  95      
Lys Lys Ala Ser Glu Asp Asp Ile Lys Lys Met Pro Leu Asp Leu Ser
            100                 105                 110         
Pro Leu Ala Thr Pro Ile Ile Arg Ser Lys Ile Glu Glu Pro Ser Val
        115                 120                 125             
Val Glu Thr Thr His Gln Asp Ser Pro Leu Pro His Pro Glu Ser Thr
    130                 135                 140                 
Thr Ser Asp Glu Lys Glu Val Pro Leu Ala Gln Thr Ala Gln Pro Thr
145                 150                 155                 160 
Ser Ala Ile Val Arg Pro Ala Ser Leu Gln Val Pro Asn Val Leu Leu
                165                 170                 175     
Thr Ser Ser Asp Ser Ser Val Ile Ile Gln Gln Ala Val Pro Ser Pro
            180                 185                 190         
Thr Ser Ser Thr Val Ile Thr Gln Ala Pro Ser Ser Asn Arg Pro Ile
        195                 200                 205             
Val
    


<210> 45
<211> 1073
<212> PRT
<213> Homo sapiens

<400> 45
Met Ala Ala Ala Gly Gln Leu Cys Leu Leu Tyr Leu Ser Ala Gly Leu
 1               5                  10                  15      
Leu Ser Arg Leu Gly Ala Ala Phe Asn Leu Asp Thr Arg Glu Asp Asn
            20                  25                  30          
Val Ile Arg Lys Tyr Gly Asp Pro Gly Ser Leu Phe Gly Phe Ser Leu
        35                  40                  45              
Ala Met His Trp Gln Leu Gln Pro Glu Asp Lys Arg Leu Leu Leu Val
    50                  55                  60                  
Gly Ala Pro Arg Ala Glu Ala Leu Pro Leu Gln Arg Ala Asn Arg Thr
65                  70                  75                  80  
Gly Gly Leu Tyr Ser Cys Asp Ile Thr Ala Arg Gly Pro Cys Thr Arg
                85                  90                  95      
Ile Glu Phe Asp Asn Asp Ala Asp Pro Thr Ser Glu Ser Lys Glu Asp
            100                 105                 110         
Gln Trp Met Gly Val Thr Val Gln Ser Gln Gly Pro Gly Gly Lys Val
        115                 120                 125             
Val Thr Cys Ala His Arg Tyr Glu Lys Arg Gln His Val Asn Thr Lys
    130                 135                 140                 
Gln Glu Ser Arg Asp Ile Phe Gly Arg Cys Tyr Val Leu Ser Gln Asn
145                 150                 155                 160 
Leu Arg Ile Glu Asp Asp Met Asp Gly Gly Asp Trp Ser Phe Cys Asp
                165                 170                 175     
Gly Arg Leu Arg Gly His Glu Lys Phe Gly Ser Cys Gln Gln Gly Val
            180                 185                 190         
Ala Ala Thr Phe Thr Lys Asp Phe His Tyr Ile Val Phe Gly Ala Pro
        195                 200                 205             
Gly Thr Tyr Asn Trp Lys Gly Ile Val Arg Val Glu Gln Lys Asn Asn
    210                 215                 220                 
Thr Phe Phe Asp Met Asn Ile Phe Glu Asp Gly Pro Tyr Glu Val Gly
225                 230                 235                 240 
Gly Glu Thr Glu His Asp Glu Ser Leu Val Pro Val Pro Ala Asn Ser
                245                 250                 255     
Tyr Leu Gly Phe Ser Leu Asp Ser Gly Lys Gly Ile Val Ser Lys Asp
            260                 265                 270         
Glu Ile Thr Phe Val Ser Gly Ala Pro Arg Ala Asn His Ser Gly Ala
        275                 280                 285             
Val Val Leu Leu Lys Arg Asp Met Lys Ser Ala His Leu Leu Pro Glu
    290                 295                 300                 
His Ile Phe Asp Gly Glu Gly Leu Ala Ser Ser Phe Gly Tyr Asp Val
305                 310                 315                 320 
Ala Val Val Asp Leu Asn Lys Asp Gly Trp Gln Asp Ile Val Ile Gly
                325                 330                 335     
Ala Pro Gln Tyr Phe Asp Arg Asp Gly Glu Val Gly Gly Ala Val Tyr
            340                 345                 350         
Val Tyr Met Asn Gln Gln Gly Arg Trp Asn Asn Val Lys Pro Ile Arg
        355                 360                 365             
Leu Asn Gly Thr Lys Asp Ser Met Phe Gly Ile Ala Val Lys Asn Ile
    370                 375                 380                 
Gly Asp Ile Asn Gln Asp Gly Tyr Pro Asp Ile Ala Val Gly Ala Pro
385                 390                 395                 400 
Tyr Asp Asp Leu Gly Lys Val Phe Ile Tyr His Gly Ser Ala Asn Gly
                405                 410                 415     
Ile Asn Thr Lys Pro Thr Gln Val Leu Lys Gly Ile Ser Pro Tyr Phe
            420                 425                 430         
Gly Tyr Ser Ile Ala Gly Asn Met Asp Leu Asp Arg Asn Ser Tyr Pro
        435                 440                 445             
Asp Val Ala Val Gly Ser Leu Ser Asp Ser Val Thr Ile Phe Arg Ser
    450                 455                 460                 
Arg Pro Val Ile Asn Ile Gln Lys Thr Ile Thr Val Thr Pro Asn Arg
465                 470                 475                 480 
Ile Asp Leu Arg Gln Lys Thr Ala Cys Gly Ala Pro Ser Gly Ile Cys
                485                 490                 495     
Leu Gln Val Lys Ser Cys Phe Glu Tyr Thr Ala Asn Pro Ala Gly Tyr
            500                 505                 510         
Asn Pro Ser Ile Ser Ile Val Gly Thr Leu Glu Ala Glu Lys Glu Arg
        515                 520                 525             
Arg Lys Ser Gly Leu Ser Ser Arg Val Gln Phe Arg Asn Gln Gly Ser
    530                 535                 540                 
Glu Pro Lys Tyr Thr Gln Glu Leu Thr Leu Lys Arg Gln Lys Gln Lys
545                 550                 555                 560 
Val Cys Met Glu Glu Thr Leu Trp Leu Gln Asp Asn Ile Arg Asp Lys
                565                 570                 575     
Leu Arg Pro Ile Pro Ile Thr Ala Ser Val Glu Ile Gln Glu Pro Ser
            580                 585                 590         
Ser Arg Arg Arg Val Asn Ser Leu Pro Glu Val Leu Pro Ile Leu Asn
        595                 600                 605             
Ser Asp Glu Pro Lys Thr Ala His Ile Asp Val His Phe Leu Lys Glu
    610                 615                 620                 
Gly Cys Gly Asp Asp Asn Val Cys Asn Ser Asn Leu Lys Leu Glu Tyr
625                 630                 635                 640 
Lys Phe Cys Thr Arg Glu Gly Asn Gln Asp Lys Phe Ser Tyr Leu Pro
                645                 650                 655     
Ile Gln Lys Gly Val Pro Glu Leu Val Leu Lys Asp Gln Lys Asp Ile
            660                 665                 670         
Ala Leu Glu Ile Thr Val Thr Asn Ser Pro Ser Asn Pro Arg Asn Pro
        675                 680                 685             
Thr Lys Asp Gly Asp Asp Ala His Glu Ala Lys Leu Ile Ala Thr Phe
    690                 695                 700                 
Pro Asp Thr Leu Thr Tyr Ser Ala Tyr Arg Glu Leu Arg Ala Phe Pro
705                 710                 715                 720 
Glu Lys Gln Leu Ser Cys Val Ala Asn Gln Asn Gly Ser Gln Ala Asp
                725                 730                 735     
Cys Glu Leu Gly Asn Pro Phe Lys Arg Asn Ser Asn Val Thr Phe Tyr
            740                 745                 750         
Leu Val Leu Ser Thr Thr Glu Val Thr Phe Asp Thr Pro Asp Leu Asp
        755                 760                 765             
Ile Asn Leu Lys Leu Glu Thr Thr Ser Asn Gln Asp Asn Leu Ala Pro
    770                 775                 780                 
Ile Thr Ala Lys Ala Lys Val Val Ile Glu Leu Leu Leu Ser Val Ser
785                 790                 795                 800 
Gly Val Ala Lys Pro Ser Gln Val Tyr Phe Gly Gly Thr Val Val Gly
                805                 810                 815     
Glu Gln Ala Met Lys Ser Glu Asp Glu Val Gly Ser Leu Ile Glu Tyr
            820                 825                 830         
Glu Phe Arg Val Ile Asn Leu Gly Lys Pro Leu Thr Asn Leu Gly Thr
        835                 840                 845             
Ala Thr Leu Asn Ile Gln Trp Pro Lys Glu Ile Ser Asn Gly Lys Trp
    850                 855                 860                 
Leu Leu Tyr Leu Val Lys Val Glu Ser Lys Gly Leu Glu Lys Val Thr
865                 870                 875                 880 
Cys Glu Pro Gln Lys Glu Ile Asn Ser Leu Asn Leu Thr Glu Ser His
                885                 890                 895     
Asn Ser Arg Lys Lys Arg Glu Ile Thr Glu Lys Gln Ile Asp Asp Asn
            900                 905                 910         
Arg Lys Phe Ser Leu Phe Ala Glu Arg Lys Tyr Gln Thr Leu Asn Cys
        915                 920                 925             
Ser Val Asn Val Asn Cys Val Asn Ile Arg Cys Pro Leu Arg Gly Leu
    930                 935                 940                 
Asp Ser Lys Ala Ser Leu Ile Leu Arg Ser Arg Leu Trp Asn Ser Thr
945                 950                 955                 960 
Phe Leu Glu Glu Tyr Ser Lys Leu Asn Tyr Leu Asp Ile Leu Met Arg
                965                 970                 975     
Ala Phe Ile Asp Val Thr Ala Ala Ala Glu Asn Ile Arg Leu Pro Asn
            980                 985                 990         
Ala Gly Thr Gln Val Arg Val Thr Val Phe Pro Ser Lys Thr Val Ala
        995                 1000                1005            
Gln Tyr Ser Gly Val Pro Trp Trp Ile Ile Leu Val Ala Ile Leu Ala
    1010                1015                1020                
Gly Ile Leu Met Leu Ala Leu Leu Val Phe Ile Leu Trp Lys Cys Gly
1025                1030                1035               1040 
Phe Phe Lys Arg Asn Lys Lys Asp His Tyr Asp Ala Thr Tyr His Lys
                1045                1050                1055    
Ala Glu Ile His Ala Gln Pro Ser Asp Lys Glu Arg Leu Thr Ser Asp
            1060                1065                1070        
Ala
    


<210> 46
<211> 421
<212> PRT
<213> Homo sapiens

<400> 46
Met Ala Ser Ser Ser Val Pro Pro Ala Thr Val Ser Ala Ala Thr Ala
 1               5                  10                  15      
Gly Pro Gly Pro Gly Phe Gly Phe Ala Ser Lys Thr Lys Lys Lys His
            20                  25                  30          
Phe Val Gln Gln Lys Val Lys Val Phe Arg Ala Ala Asp Pro Leu Val
        35                  40                  45              
Gly Val Phe Leu Trp Gly Val Ala His Ser Ile Asn Glu Leu Ser Gln
    50                  55                  60                  
Val Pro Pro Pro Val Met Leu Leu Pro Asp Asp Phe Lys Ala Ser Ser
65                  70                  75                  80  
Lys Ile Lys Val Asn Asn His Leu Phe His Arg Glu Asn Leu Pro Ser
                85                  90                  95      
His Phe Lys Phe Lys Glu Tyr Cys Pro Gln Val Phe Arg Asn Leu Arg
            100                 105                 110         
Asp Arg Phe Gly Ile Asp Asp Gln Asp Tyr Leu Val Ser Leu Thr Arg
        115                 120                 125             
Asn Pro Pro Ser Glu Ser Glu Gly Ser Asp Gly Arg Phe Leu Ile Ser
    130                 135                 140                 
Tyr Asp Arg Thr Leu Val Ile Lys Glu Val Ser Ser Glu Asp Ile Ala
145                 150                 155                 160 
Asp Met His Ser Asn Leu Ser Asn Tyr His Gln Tyr Ile Val Lys Cys
                165                 170                 175     
His Gly Asn Thr Leu Leu Pro Gln Phe Leu Gly Met Tyr Arg Val Ser
            180                 185                 190         
Val Asp Asn Glu Asp Ser Tyr Met Leu Val Met Arg Asn Met Phe Ser
        195                 200                 205             
His Arg Leu Pro Val His Arg Lys Tyr Asp Leu Lys Gly Ser Leu Val
    210                 215                 220                 
Ser Arg Glu Ala Ser Asp Lys Glu Lys Val Lys Glu Leu Pro Thr Leu
225                 230                 235                 240 
Arg Asp Met Asp Phe Leu Asn Lys Asn Gln Lys Val Tyr Ile Gly Glu
                245                 250                 255     
Glu Glu Lys Lys Ile Phe Leu Glu Lys Leu Lys Arg Asp Val Glu Phe
            260                 265                 270         
Leu Val Gln Leu Lys Ile Met Asp Tyr Ser Leu Leu Leu Gly Ile His
        275                 280                 285             
Asp Ile Ile Arg Gly Ser Glu Pro Glu Glu Glu Ala Pro Val Arg Glu
    290                 295                 300                 
Asp Glu Ser Glu Val Asp Gly Asp Cys Ser Leu Thr Gly Pro Pro Ala
305                 310                 315                 320 
Leu Val Gly Ser Tyr Gly Thr Ser Pro Glu Gly Ile Gly Gly Tyr Ile
                325                 330                 335     
His Ser His Arg Pro Leu Gly Pro Gly Glu Phe Glu Ser Phe Ile Asp
            340                 345                 350         
Val Tyr Ala Ile Arg Ser Ala Glu Gly Ala Pro Gln Lys Glu Val Tyr
        355                 360                 365             
Phe Met Gly Leu Ile Asp Ile Leu Thr Gln Tyr Asp Ala Lys Lys Lys
    370                 375                 380                 
Ala Ala His Ala Ala Lys Thr Val Lys His Gly Ala Gly Ala Glu Ile
385                 390                 395                 400 
Ser Thr Val His Pro Glu Gln Tyr Ala Lys Arg Phe Leu Asp Phe Ile
                405                 410                 415     
Thr Asn Ile Phe Ala
            420     


<210> 47
<211> 619
<212> PRT
<213> Homo sapiens

<400> 47
Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser
 1               5                  10                  15      
Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly
            20                  25                  30          
Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu
        35                  40                  45              
Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln
    50                  55                  60                  
Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro
65                  70                  75                  80  
Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys
                85                  90                  95      
Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro
            100                 105                 110         
Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg
        115                 120                 125             
Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser
    130                 135                 140                 
Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg
145                 150                 155                 160 
Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys
                165                 170                 175     
Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg
            180                 185                 190         
Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val
        195                 200                 205             
Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro
    210                 215                 220                 
Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys
225                 230                 235                 240 
Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn
                245                 250                 255     
Ser Ser Ala Ser Asn Ala Ser Gly Ala Ala Ala Pro Thr Leu Pro Ala
            260                 265                 270         
His Pro Ser Thr Leu Thr His Pro Gln Arg Arg Ile Asp Thr Leu Asn
        275                 280                 285             
Ser Asp Gly Tyr Thr Pro Glu Pro Ala Arg Ile Thr Ser Pro Asp Lys
    290                 295                 300                 
Pro Arg Pro Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser
305                 310                 315                 320 
Asp Pro Glu Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn
                325                 330                 335     
Leu Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val
            340                 345                 350         
Arg Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile
        355                 360                 365             
Lys Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met
    370                 375                 380                 
Arg Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg
385                 390                 395                 400 
Leu Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Met Glu Met
                405                 410                 415     
Ala Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu
            420                 425                 430         
Ile Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly
        435                 440                 445             
Met Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala
    450                 455                 460                 
Arg Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe
465                 470                 475                 480 
Gly Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg
                485                 490                 495     
Ser Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn
            500                 505                 510         
Phe Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr
        515                 520                 525             
Met Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys
    530                 535                 540                 
Gly Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys
545                 550                 555                 560 
Pro Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp
                565                 570                 575     
Ile Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg
            580                 585                 590         
Met Arg Ala Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly Pro Pro
        595                 600                 605             
Gly Ser Thr Gln Lys Ala Glu Ala Ala Cys Ala
    610                 615                 


<210> 48
<211> 418
<212> PRT
<213> Homo sapiens

<400> 48
Met Lys Asn Lys Pro Gly Pro Tyr Ser Ser Val Pro Pro Pro Ser Ala
 1               5                  10                  15      
Pro Pro Pro Lys Lys Ser Leu Gly Thr Gln Pro Pro Lys Lys Ala Val
            20                  25                  30          
Glu Lys Gln Gln Pro Val Glu Ser Ser Glu Asp Ser Ser Asp Glu Ser
        35                  40                  45              
Asp Ser Ser Ser Glu Glu Glu Lys Lys Pro Pro Thr Lys Ala Val Val
    50                  55                  60                  
Ser Lys Ala Thr Thr Lys Pro Pro Pro Ala Lys Lys Ala Ala Glu Ser
65                  70                  75                  80  
Ser Ser Asp Ser Ser Asp Ser Asp Ser Ser Glu Asp Asp Glu Ala Pro
                85                  90                  95      
Ser Lys Pro Ala Gly Thr Thr Lys Asn Ser Ser Asn Lys Pro Ala Val
            100                 105                 110         
Thr Thr Lys Ser Pro Ala Val Lys Pro Ala Ala Ala Pro Lys Gln Pro
        115                 120                 125             
Val Gly Gly Gly Gln Lys Leu Leu Thr Arg Lys Ala Asp Ser Ser Ser
    130                 135                 140                 
Ser Glu Glu Glu Ser Ser Ser Ser Glu Glu Glu Lys Thr Lys Lys Met
145                 150                 155                 160 
Val Ala Thr Thr Lys Pro Lys Ala Thr Ala Lys Ala Ala Leu Ser Leu
                165                 170                 175     
Pro Ala Lys Gln Ala Pro Gln Gly Ser Arg Asp Ser Ser Ser Asp Ser
            180                 185                 190         
Asp Ser Ser Ser Ser Glu Glu Glu Glu Glu Lys Thr Ser Lys Ser Ala
        195                 200                 205             
Val Lys Lys Lys Pro Gln Lys Val Ala Gly Gly Ala Ala Pro Ser Lys
    210                 215                 220                 
Pro Ala Ser Ala Lys Lys Gly Lys Ala Glu Ser Ser Asn Ser Ser Ser
225                 230                 235                 240 
Ser Asp Asp Ser Ser Glu Glu Glu Glu Glu Lys Leu Lys Gly Lys Gly
                245                 250                 255     
Ser Pro Arg Pro Gln Ala Pro Lys Ala Asn Gly Thr Ser Ala Leu Thr
            260                 265                 270         
Ala Gln Asn Gly Lys Ala Ala Lys Asn Ser Glu Glu Glu Glu Glu Glu
        275                 280                 285             
Lys Lys Lys Ala Ala Val Val Val Ser Lys Ser Gly Ser Leu Lys Lys
    290                 295                 300                 
Arg Lys Gln Asn Glu Ala Ala Lys Glu Ala Glu Thr Pro Gln Ala Lys
305                 310                 315                 320 
Lys Ile Lys Leu Gln Thr Pro Asn Thr Phe Pro Lys Arg Lys Lys Gly
                325                 330                 335     
Glu Lys Arg Ala Ser Ser Pro Phe Arg Arg Val Arg Glu Glu Glu Ile
            340                 345                 350         
Glu Val Asp Ser Arg Val Ala Asp Asn Ser Phe Asp Ala Lys Arg Gly
        355                 360                 365             
Ala Ala Gly Asp Trp Gly Glu Arg Ala Asn Gln Val Leu Lys Phe Thr
    370                 375                 380                 
Lys Gly Lys Ser Phe Arg His Glu Lys Thr Lys Lys Lys Arg Gly Ser
385                 390                 395                 400 
Tyr Arg Gly Gly Ser Ile Ser Val Gln Val Asn Ser Ile Lys Phe Asp
                405                 410                 415     
Ser Glu
        


<210> 49
<211> 279
<212> PRT
<213> Homo sapiens

<400> 49
Met Ser Val Ala Gly Leu Lys Lys Gln Phe His Lys Ala Thr Gln Lys
 1               5                  10                  15      
Val Ser Glu Lys Val Gly Gly Ala Glu Gly Thr Lys Leu Asp Asp Asp
            20                  25                  30          
Phe Lys Glu Met Glu Arg Lys Val Asp Val Thr Ser Arg Ala Val Met
        35                  40                  45              
Glu Ile Met Thr Lys Thr Ile Glu Tyr Leu Gln Pro Asn Pro Ala Ser
    50                  55                  60                  
Arg Ala Lys Leu Ser Met Ile Asn Thr Met Ser Lys Ile Arg Gly Gln
65                  70                  75                  80  
Glu Lys Gly Pro Gly Tyr Pro Gln Ala Glu Ala Leu Leu Ala Glu Ala
                85                  90                  95      
Met Leu Lys Phe Gly Arg Glu Leu Gly Asp Asp Cys Asn Phe Gly Pro
            100                 105                 110         
Ala Leu Gly Glu Val Gly Glu Ala Met Arg Glu Leu Ser Glu Val Lys
        115                 120                 125             
Asp Ser Leu Asp Ile Glu Val Lys Gln Asn Phe Ile Asp Pro Leu Gln
    130                 135                 140                 
Asn Leu His Asp Lys Asp Leu Arg Glu Ile Gln His His Leu Lys Lys
145                 150                 155                 160 
Leu Glu Gly Arg Arg Leu Asp Phe Asp Tyr Lys Lys Glu Arg Gln Gly
                165                 170                 175     
Lys Ile Pro Asp Glu Glu Leu Arg Gln Ala Leu Glu Lys Phe Asp Glu
            180                 185                 190         
Ser Lys Glu Ile Ala Glu Ser Ser Met Phe Asn Leu Leu Glu Met Asp
        195                 200                 205             
Ile Glu Gln Val Ser Gln Leu Ser Ala Leu Val Gln Ala Gln Leu Glu
    210                 215                 220                 
Tyr His Lys Gln Ala Val Gln Ile Leu Gln Gln Val Thr Val Arg Leu
225                 230                 235                 240 
Glu Glu Arg Ile Arg Gln Ala Ser Ser Gln Pro Arg Arg Glu Tyr Gln
                245                 250                 255     
Pro Lys Pro Arg Met Ser Leu Glu Phe Pro Thr Gly Asp Ser Thr Gln
            260                 265                 270         
Pro Asn Gly Gly Leu Ser His
        275                 


<210> 50
<211> 631
<212> PRT
<213> Homo sapiens

<400> 50
Met Thr Ser Ala Asn Lys Ala Ile Glu Leu Gln Leu Gln Val Lys Gln
 1               5                  10                  15      
Asn Ala Glu Glu Leu Gln Asp Phe Met Arg Asp Leu Glu Asn Trp Glu
            20                  25                  30          
Lys Asp Ile Lys Gln Lys Asp Met Glu Leu Arg Arg Gln Asn Gly Val
        35                  40                  45              
Pro Glu Glu Asn Leu Pro Pro Ile Arg Asn Gly Asn Phe Arg Lys Lys
    50                  55                  60                  
Lys Lys Gly Lys Ala Lys Glu Ser Ser Lys Lys Thr Arg Glu Glu Asn
65                  70                  75                  80  
Thr Lys Asn Arg Ile Lys Ser Tyr Asp Tyr Glu Ala Trp Ala Lys Leu
                85                  90                  95      
Asp Val Asp Arg Ile Leu Asp Glu Leu Asp Lys Asp Asp Ser Thr His
            100                 105                 110         
Glu Ser Leu Ser Gln Glu Ser Glu Ser Glu Glu Asp Gly Ile His Val
        115                 120                 125             
Asp Ser Gln Lys Ala Leu Val Leu Lys Glu Lys Gly Asn Lys Tyr Phe
    130                 135                 140                 
Lys Gln Gly Lys Tyr Asp Glu Ala Ile Asp Cys Tyr Thr Lys Gly Met
145                 150                 155                 160 
Asp Ala Asp Pro Tyr Asn Pro Val Leu Pro Thr Asn Arg Ala Ser Ala
                165                 170                 175     
Tyr Phe Arg Leu Lys Lys Phe Ala Val Ala Glu Ser Asp Cys Asn Leu
            180                 185                 190         
Ala Val Ala Leu Asn Arg Ser Tyr Thr Lys Ala Tyr Ser Arg Arg Gly
        195                 200                 205             
Ala Ala Arg Phe Ala Leu Gln Lys Leu Glu Glu Ala Lys Lys Asp Tyr
    210                 215                 220                 
Glu Arg Val Leu Glu Leu Glu Pro Asn Asn Phe Glu Ala Thr Asn Glu
225                 230                 235                 240 
Leu Arg Lys Ile Ser Gln Ala Leu Ala Ser Lys Glu Asn Ser Tyr Pro
                245                 250                 255     
Lys Glu Ala Asp Ile Val Ile Lys Ser Thr Glu Gly Glu Arg Lys Gln
            260                 265                 270         
Ile Glu Ala Gln Gln Asn Lys Gln Gln Ala Ile Ser Glu Lys Asp Arg
        275                 280                 285             
Gly Asn Gly Phe Phe Lys Glu Gly Lys Tyr Glu Arg Ala Ile Glu Cys
    290                 295                 300                 
Tyr Thr Arg Gly Ile Ala Ala Asp Gly Ala Asn Ala Leu Leu Pro Ala
305                 310                 315                 320 
Asn Arg Ala Met Ala Tyr Leu Lys Ile Gln Lys Tyr Glu Glu Ala Glu
                325                 330                 335     
Lys Asp Cys Thr Gln Ala Ile Leu Leu Asp Gly Ser Tyr Ser Lys Ala
            340                 345                 350         
Phe Ala Arg Arg Gly Thr Ala Arg Thr Phe Leu Gly Lys Leu Asn Glu
        355                 360                 365             
Ala Lys Gln Asp Phe Glu Thr Val Leu Leu Leu Glu Pro Gly Asn Lys
    370                 375                 380                 
Gln Ala Val Thr Glu Leu Ser Lys Ile Lys Lys Lys Pro Leu Lys Lys
385                 390                 395                 400 
Val Ile Ile Glu Glu Thr Gly Asn Leu Ile Gln Thr Ile Asp Val Pro
                405                 410                 415     
Asp Ser Thr Thr Ala Ala Ala Pro Glu Asn Asn Pro Ile Asn Leu Ala
            420                 425                 430         
Asn Val Ile Ala Ala Thr Gly Thr Thr Ser Lys Lys Asn Ser Ser Gln
        435                 440                 445             
Asp Asp Leu Phe Pro Thr Ser Asp Thr Pro Arg Ala Lys Val Leu Lys
    450                 455                 460                 
Ile Glu Glu Val Ser Asp Thr Ser Ser Leu Gln Pro Gln Ala Ser Leu
465                 470                 475                 480 
Lys Gln Asp Val Cys Gln Ser Tyr Ser Glu Lys Met Pro Ile Glu Ile
                485                 490                 495     
Glu Gln Lys Pro Ala Gln Phe Ala Thr Thr Val Leu Pro Pro Ile Pro
            500                 505                 510         
Ala Asn Ser Phe Gln Leu Glu Ser Asp Phe Arg Gln Leu Lys Ser Ser
        515                 520                 525             
Pro Asp Met Leu Tyr Gln Tyr Leu Lys Gln Ile Glu Pro Ser Leu Tyr
    530                 535                 540                 
Pro Lys Leu Phe Gln Lys Asn Leu Asp Pro Asp Val Phe Asn Gln Ile
545                 550                 555                 560 
Val Lys Ile Leu His Asp Phe Tyr Ile Glu Lys Glu Lys Pro Leu Leu
                565                 570                 575     
Ile Phe Glu Ile Leu Gln Arg Leu Ser Glu Leu Lys Arg Phe Asp Met
            580                 585                 590         
Ala Val Met Phe Met Ser Glu Thr Glu Lys Lys Ile Ala Arg Ala Leu
        595                 600                 605             
Phe Asn His Ile Asp Lys Ser Gly Leu Lys Asp Ser Ser Val Glu Glu
    610                 615                 620                 
Leu Lys Lys Arg Tyr Gly Gly
625                 630     


<210> 51
<211> 362
<212> PRT
<213> Homo sapiens

<400> 51
Met Ala Cys Ala Gly Leu Leu Thr Val Cys Leu Leu Arg Pro Pro Ala
 1               5                  10                  15      
Pro Gln Pro Gln Pro Gln Thr Pro Arg His Pro Gln Leu Ala Pro Asp
            20                  25                  30          
Pro Gly Pro Ala Gly His Thr Leu Phe Gln Asp Val Phe Arg Arg Ala
        35                  40                  45              
Asp Lys Asn Asp Asp Gly Lys Leu Ser Phe Glu Glu Phe Gln Asn Tyr
    50                  55                  60                  
Phe Ala Asp Gly Val Leu Ser Leu Gly Glu Leu Gln Glu Leu Phe Ser
65                  70                  75                  80  
Gly Ile Asp Gly His Leu Thr Asp Asn Leu Glu Thr Glu Lys Leu Cys
                85                  90                  95      
Asp Tyr Phe Ser Glu His Leu Gly Val Tyr Arg Pro Val Leu Ala Ala
            100                 105                 110         
Leu Glu Ser Leu Asn Arg Ala Val Leu Ala Ala Met Asp Ala Thr Lys
        115                 120                 125             
Leu Glu Tyr Glu Arg Ala Ser Lys Val Asp Gln Phe Val Thr Arg Phe
    130                 135                 140                 
Leu Leu Arg Glu Thr Val Ser Gln Leu Gln Ala Leu Gln Ser Ser Leu
145                 150                 155                 160 
Glu Gly Ala Ser Asp Thr Leu Glu Ala Gln Ala His Gly Trp Arg Ser
                165                 170                 175     
Asp Ala Glu Ser Val Glu Ala Gln Ser Arg Leu Cys Gly Ser Arg Arg
            180                 185                 190         
Ala Gly Arg Arg Ala Leu Arg Ser Val Ser Arg Ser Ser Thr Trp Ser
        195                 200                 205             
Pro Gly Ser Ser Asp Thr Gly Arg Ser Ser Glu Ala Glu Met Gln Trp
    210                 215                 220                 
Arg Leu Gln Val Asn Arg Leu Gln Glu Leu Ile Asp Gln Leu Glu Cys
225                 230                 235                 240 
Lys Ala Pro Arg Leu Glu Pro Leu Arg Glu Glu Asp Leu Ala Lys Gly
                245                 250                 255     
Pro Asp Leu His Ile Leu Met Ala Gln Arg Gln Val Gln Val Ala Glu
            260                 265                 270         
Glu Gly Leu Gln Asp Phe His Arg Ala Leu Arg Cys Tyr Val Asp Phe
        275                 280                 285             
Thr Gly Ala Gln Ser His Cys Leu His Val Ser Ala Gln Lys Met Leu
    290                 295                 300                 
Asp Gly Ala Ser Phe Thr Leu Tyr Glu Phe Trp Gln Asp Glu Ala Ser
305                 310                 315                 320 
Trp Arg Arg His Gln Gln Ser Pro Gly Ser Lys Ala Phe Gln Arg Ile
                325                 330                 335     
Leu Ile Asp His Leu Arg Ala Pro Asp Thr Leu Thr Thr Val Phe Phe
            340                 345                 350         
Pro Ala Ser Trp Trp Ile Met Asn Asn Asn
        355                 360         


<210> 52
<211> 181
<212> PRT
<213> Homo sapiens

<400> 52
Met Ala Gly Ser Arg Glu Val Val Ala Met Asp Cys Glu Met Val Gly
 1               5                  10                  15      
Leu Gly Pro His Arg Glu Ser Gly Leu Ala Arg Cys Ser Leu Val Asn
            20                  25                  30          
Val His Gly Ala Val Leu Tyr Asp Lys Phe Ile Arg Pro Glu Gly Glu
        35                  40                  45              
Ile Thr Asp Tyr Arg Thr Arg Val Ser Gly Val Thr Pro Gln His Met
    50                  55                  60                  
Val Gly Ala Thr Pro Phe Ala Val Ala Arg Leu Glu Ile Leu Gln Leu
65                  70                  75                  80  
Leu Lys Gly Lys Leu Val Val Gly His Asp Leu Lys His Asp Phe Gln
                85                  90                  95      
Ala Leu Lys Glu Asp Met Ser Gly Tyr Thr Ile Tyr Asp Thr Ser Thr
            100                 105                 110         
Asp Arg Leu Leu Trp Arg Glu Ala Lys Leu Asp His Cys Arg Arg Val
        115                 120                 125             
Ser Leu Arg Val Leu Ser Glu Arg Leu Leu His Lys Ser Ile Gln Asn
    130                 135                 140                 
Ser Leu Leu Gly His Ser Ser Val Glu Asp Ala Arg Ala Thr Met Glu
145                 150                 155                 160 
Leu Tyr Gln Ile Ser Gln Arg Ile Arg Ala Arg Arg Gly Leu Pro Arg
                165                 170                 175     
Leu Ala Val Ser Asp
            180     


<210> 53
<211> 85
<212> PRT
<213> Homo sapiens

<400> 53
Met Glu Phe Asp Leu Gly Ala Ala Leu Glu Pro Thr Ser Gln Lys Pro
 1               5                  10                  15      
Gly Val Gly Ala Gly His Gly Gly Asp Pro Lys Leu Ser Pro His Lys
            20                  25                  30          
Val Gln Gly Arg Ser Glu Ala Gly Ala Gly Pro Gly Pro Lys Ala Ser
        35                  40                  45              
Asn Phe Arg Gly Leu Gly Lys Gly Arg Arg Leu Thr Ala Ala Pro Pro
    50                  55                  60                  
Ser Ser Lys Asp Thr Thr Ala Leu Pro Thr Pro Ala Ala Ala Pro Ala
65                  70                  75                  80  
Ile Arg Thr Arg Met
                85  


<210> 54
<211> 475
<212> PRT
<213> Homo sapiens

<400> 54
Met Ala Ser Ala Ala Arg Leu Thr Met Met Trp Glu Glu Val Thr Cys
 1               5                  10                  15      
Pro Ile Cys Leu Asp Pro Phe Val Glu Pro Val Ser Ile Glu Cys Gly
            20                  25                  30          
His Ser Phe Cys Gln Glu Cys Ile Ser Gln Val Gly Lys Gly Gly Gly
        35                  40                  45              
Ser Val Cys Pro Val Cys Arg Gln Arg Phe Leu Leu Lys Asn Leu Arg
    50                  55                  60                  
Pro Asn Arg Gln Leu Ala Asn Met Val Asn Asn Leu Lys Glu Ile Ser
65                  70                  75                  80  
Gln Glu Ala Arg Glu Gly Thr Gln Gly Glu Arg Cys Ala Val His Gly
                85                  90                  95      
Glu Arg Leu His Leu Phe Cys Glu Lys Asp Gly Lys Ala Leu Cys Trp
            100                 105                 110         
Val Cys Ala Gln Ser Arg Lys His Arg Asp His Ala Met Val Pro Leu
        115                 120                 125             
Glu Glu Ala Ala Gln Glu Tyr Gln Glu Lys Leu Gln Val Ala Leu Gly
    130                 135                 140                 
Glu Leu Arg Arg Lys Gln Glu Leu Ala Glu Lys Leu Glu Val Glu Ile
145                 150                 155                 160 
Ala Ile Lys Arg Ala Asp Trp Lys Lys Thr Val Glu Thr Gln Lys Ser
                165                 170                 175     
Arg Ile His Ala Glu Phe Val Gln Gln Lys Asn Phe Leu Val Glu Glu
            180                 185                 190         
Glu Gln Arg Gln Leu Gln Glu Leu Glu Lys Asp Glu Arg Glu Gln Leu
        195                 200                 205             
Arg Ile Leu Gly Glu Lys Glu Ala Lys Leu Ala Gln Gln Ser Gln Ala
    210                 215                 220                 
Leu Gln Glu Leu Ile Ser Glu Leu Asp Arg Arg Cys His Ser Ser Ala
225                 230                 235                 240 
Leu Glu Leu Leu Gln Glu Val Ile Ile Val Leu Glu Arg Ser Glu Ser
                245                 250                 255     
Trp Asn Leu Lys Asp Leu Asp Ile Thr Ser Pro Glu Leu Arg Ser Val
            260                 265                 270         
Cys His Val Pro Gly Leu Lys Lys Met Leu Arg Thr Cys Ala Val His
        275                 280                 285             
Ile Thr Leu Asp Pro Asp Thr Ala Asn Pro Trp Leu Ile Leu Ser Glu
    290                 295                 300                 
Asp Arg Arg Gln Val Arg Leu Gly Asp Thr Gln Gln Ser Ile Pro Gly
305                 310                 315                 320 
Asn Glu Glu Arg Phe Asp Ser Tyr Pro Met Val Leu Gly Ala Gln His
                325                 330                 335     
Phe His Ser Gly Lys His Tyr Trp Glu Val Asp Val Thr Gly Lys Glu
            340                 345                 350         
Ala Trp Asp Leu Gly Val Cys Arg Asp Ser Val Arg Arg Lys Gly His
        355                 360                 365             
Phe Leu Leu Ser Ser Lys Ser Gly Phe Trp Thr Ile Trp Leu Trp Asn
    370                 375                 380                 
Lys Gln Lys Tyr Glu Ala Gly Thr Tyr Pro Gln Thr Pro Leu His Leu
385                 390                 395                 400 
Gln Val Pro Pro Cys Gln Val Gly Ile Phe Leu Asp Tyr Glu Ala Gly
                405                 410                 415     
Met Val Ser Phe Tyr Asn Ile Thr Asp His Gly Ser Leu Ile Tyr Ser
            420                 425                 430         
Phe Ser Glu Cys Ala Phe Thr Gly Pro Leu Arg Pro Phe Phe Ser Pro
        435                 440                 445             
Gly Phe Asn Asp Gly Gly Lys Asn Thr Ala Pro Leu Thr Leu Cys Pro
    450                 455                 460                 
Leu Asn Ile Gly Ser Gln Gly Ser Thr Asp Tyr
465                 470                 475 


<210> 55
<211> 454
<212> PRT
<213> Homo sapiens

<400> 55
Met Ala Glu Phe Ser Gln Lys Arg Gly Lys Arg Arg Ser Asp Glu Gly
 1               5                  10                  15      
Leu Gly Ser Met Val Asp Phe Leu Leu Ala Asn Ala Arg Leu Val Leu
            20                  25                  30          
Gly Val Gly Gly Ala Ala Val Leu Gly Ile Ala Thr Leu Ala Val Lys
        35                  40                  45              
Arg Phe Ile Asp Arg Ala Thr Ser Pro Arg Asp Glu Asp Asp Thr Lys
    50                  55                  60                  
Ala Asp Ser Trp Lys Glu Leu Ser Leu Leu Lys Ala Thr Pro His Leu
65                  70                  75                  80  
Gln Pro Arg Pro Pro Pro Ala Ala Leu Ser Gln Pro Val Leu Pro Leu
                85                  90                  95      
Ala Pro Ser Ser Ser Ala Pro Glu Gly Pro Ala Glu Thr Asp Pro Glu
            100                 105                 110         
Val Thr Pro Gln Leu Ser Ser Pro Ala Pro Leu Cys Leu Thr Leu Gln
        115                 120                 125             
Glu Arg Leu Leu Ala Phe Glu Arg Asp Arg Val Thr Ile Pro Ala Ala
    130                 135                 140                 
Gln Val Ala Leu Ala Lys Gln Leu Ala Gly Asp Ile Ala Leu Glu Leu
145                 150                 155                 160 
Gln Ala Tyr Phe Arg Ser Lys Phe Pro Glu Leu Pro Phe Gly Ala Phe
                165                 170                 175     
Val Pro Gly Gly Pro Leu Tyr Asp Gly Leu Gln Ala Gly Ala Ala Asp
            180                 185                 190         
His Val Arg Leu Leu Val Pro Leu Val Leu Glu Pro Gly Leu Trp Ser
        195                 200                 205             
Leu Val Pro Gly Val Asp Thr Val Ala Arg Asp Pro Arg Cys Trp Ala
    210                 215                 220                 
Val Arg Arg Thr Gln Leu Glu Phe Cys Pro Arg Gly Ser Ser Pro Trp
225                 230                 235                 240 
Asp Arg Phe Leu Val Gly Gly Tyr Leu Ser Ser Arg Val Leu Leu Glu
                245                 250                 255     
Leu Leu Arg Lys Ala Leu Ala Ala Ser Val Asn Trp Pro Ala Ile Gly
            260                 265                 270         
Ser Leu Leu Gly Cys Leu Ile Arg Pro Ser Met Ala Ser Glu Glu Leu
        275                 280                 285             
Leu Leu Glu Val Gln His Glu Arg Leu Glu Leu Thr Val Ala Val Leu
    290                 295                 300                 
Val Ala Val Pro Gly Val Asp Ala Asp Asp Arg Leu Leu Leu Ala Trp
305                 310                 315                 320 
Pro Leu Glu Gly Leu Ala Gly Asn Leu Trp Leu Gln Asp Leu Tyr Pro
                325                 330                 335     
Val Glu Ala Ala Arg Leu Arg Ala Leu Asp Asp His Asp Ala Gly Thr
            340                 345                 350         
Arg Arg Arg Leu Leu Leu Leu Leu Cys Ala Val Cys Arg Gly Cys Ser
        355                 360                 365             
Ala Leu Gly Gln Leu Gly Arg Gly His Leu Thr Gln Val Val Leu Arg
    370                 375                 380                 
Leu Gly Glu Asp Asn Val Asp Trp Thr Glu Glu Ala Leu Gly Glu Arg
385                 390                 395                 400 
Phe Leu Gln Ala Leu Glu Leu Leu Ile Gly Ser Leu Glu Gln Ala Ser
                405                 410                 415     
Leu Pro Cys His Phe Asn Pro Ser Val Asn Leu Phe Ser Ser Leu Arg
            420                 425                 430         
Glu Glu Glu Ile Asp Asp Ile Gly Tyr Ala Leu Tyr Ser Gly Leu Gln
        435                 440                 445             
Glu Pro Glu Gly Leu Leu
    450                 


<210> 56
<211> 282
<212> PRT
<213> Homo sapiens

<400> 56
Met Ala Val Pro Glu Thr Arg Pro Asn His Thr Ile Tyr Ile Asn Asn
 1               5                  10                  15      
Leu Asn Glu Lys Ile Lys Lys Asp Glu Leu Lys Lys Ser Leu Tyr Ala
            20                  25                  30          
Ile Phe Ser Gln Phe Gly Gln Ile Leu Asp Ile Leu Val Ser Arg Ser
        35                  40                  45              
Leu Lys Met Arg Gly Gln Ala Phe Val Ile Phe Lys Glu Val Ser Ser
    50                  55                  60                  
Ala Thr Asn Ala Leu Arg Ser Met Gln Gly Phe Pro Phe Tyr Asp Lys
65                  70                  75                  80  
Pro Met Arg Ile Gln Tyr Ala Lys Thr Asp Ser Asp Ile Ile Ala Lys
                85                  90                  95      
Met Lys Gly Thr Phe Val Glu Arg Asp Arg Lys Arg Glu Lys Arg Lys
            100                 105                 110         
Pro Lys Ser Gln Glu Thr Pro Ala Thr Lys Lys Ala Val Gln Gly Gly
        115                 120                 125             
Gly Ala Thr Pro Val Val Gly Ala Val Gln Gly Pro Val Pro Gly Met
    130                 135                 140                 
Pro Pro Met Thr Gln Ala Pro Arg Ile Met His His Met Pro Gly Gln
145                 150                 155                 160 
Pro Pro Tyr Met Pro Pro Pro Gly Met Ile Pro Pro Pro Gly Leu Ala
                165                 170                 175     
Pro Gly Gln Ile Pro Pro Gly Ala Met Pro Pro Gln Gln Leu Met Pro
            180                 185                 190         
Gly Gln Met Pro Pro Ala Gln Pro Leu Ser Glu Asn Pro Pro Asn His
        195                 200                 205             
Ile Leu Phe Leu Thr Asn Leu Pro Glu Glu Thr Asn Glu Leu Met Leu
    210                 215                 220                 
Ser Met Leu Phe Asn Gln Phe Pro Gly Phe Lys Glu Val Arg Leu Val
225                 230                 235                 240 
Pro Gly Arg His Asp Ile Ala Phe Val Glu Phe Asp Asn Glu Val Gln
                245                 250                 255     
Ala Gly Ala Ala Arg Asp Ala Leu Gln Gly Phe Lys Ile Thr Gln Asn
            260                 265                 270         
Asn Ala Met Lys Ile Ser Phe Ala Lys Lys
        275                 280         


<210> 57
<211> 115
<212> PRT
<213> Homo sapiens

<400> 57
Met Arg Tyr Val Ala Ser Tyr Leu Leu Ala Ala Leu Gly Gly Asn Ser
 1               5                  10                  15      
Ser Pro Ser Ala Lys Asp Ile Lys Lys Ile Leu Asp Ser Val Gly Ile
            20                  25                  30          
Glu Ala Asp Asp Asp Arg Leu Asn Lys Val Ile Ser Glu Leu Asn Gly
        35                  40                  45              
Lys Asn Ile Glu Asp Val Ile Ala Gln Gly Ile Gly Lys Leu Ala Ser
    50                  55                  60                  
Val Pro Ala Gly Gly Ala Val Ala Val Ser Ala Ala Pro Gly Ser Ala
65                  70                  75                  80  
Ala Pro Ala Ala Gly Ser Ala Pro Ala Ala Ala Glu Glu Lys Lys Asp
                85                  90                  95      
Glu Lys Lys Glu Glu Ser Glu Glu Ser Asp Asp Asp Met Gly Phe Gly
            100                 105                 110         
Leu Phe Asp
        115 


<210> 58
<211> 614
<212> PRT
<213> Homo sapiens

<400> 58
Cys Met Gln Val Gly Cys Asn Lys Val Tyr Thr Ser Thr Ser Asp Val
 1               5                  10                  15      
Met Thr His Glu Asn Phe His Lys Lys Asn Thr Gln Leu Ile Asn Asp
            20                  25                  30          
Gly Phe Gln Arg Phe Arg Ala Thr Glu Asp Cys Gly Thr Ala Asp Cys
        35                  40                  45              
Gln Phe Tyr Gly Gln Lys Thr Thr His Phe His Cys Arg Arg Pro Gly
    50                  55                  60                  
Cys Thr Phe Thr Phe Lys Asn Lys Cys Asp Ile Glu Lys His Lys Ser
65                  70                  75                  80  
Tyr His Ile Lys Asp Asp Ala Tyr Ala Lys Asp Gly Phe Lys Lys Phe
                85                  90                  95      
Tyr Lys Tyr Glu Glu Cys Lys Tyr Glu Gly Cys Val Tyr Ser Lys Ala
            100                 105                 110         
Thr Asn His Phe His Cys Ile Arg Ala Gly Cys Gly Phe Thr Phe Thr
        115                 120                 125             
Ser Thr Ser Gln Met Thr Ser His Lys Arg Lys His Glu Arg Arg His
    130                 135                 140                 
Ile Arg Ser Ser Gly Ala Leu Gly Leu Pro Pro Ser Leu Leu Gly Ala
145                 150                 155                 160 
Lys Asp Thr Glu His Glu Glu Ser Ser Asn Asp Asp Leu Val Asp Phe
                165                 170                 175     
Ser Ala Leu Ser Ser Lys Asn Ser Ser Leu Ser Ala Ser Pro Thr Ser
            180                 185                 190         
Gln Gln Ser Ser Ala Ser Leu Ala Ala Ala Thr Ala Ala Thr Glu Ala
        195                 200                 205             
Gly Pro Ser Ala Thr Lys Pro Pro Asn Ser Lys Ile Ser Gly Leu Leu
    210                 215                 220                 
Pro Gln Gly Leu Pro Gly Ser Ile Pro Leu Ala Leu Ala Leu Ser Asn
225                 230                 235                 240 
Ser Gly Leu Pro Thr Pro Thr Pro Tyr Phe Pro Ile Leu Ala Gly Arg
                245                 250                 255     
Gly Ser Thr Ser Leu Pro Val Gly Thr Pro Ser Leu Leu Gly Ala Val
            260                 265                 270         
Ser Ser Gly Ser Ala Ala Ser Ala Thr Pro Asp Thr Pro Thr Leu Val
        275                 280                 285             
Ala Ser Gly Ala Gly Asp Ser Ala Pro Val Ala Ala Ala Ser Val Pro
    290                 295                 300                 
Ala Pro Pro Ala Ser Ile Met Glu Arg Ile Ser Ala Ser Lys Gly Leu
305                 310                 315                 320 
Ile Ser Pro Met Met Ala Arg Leu Ala Ala Ala Ala Leu Lys Pro Ser
                325                 330                 335     
Ala Thr Phe Asp Pro Gly Ser Gly Gln Gln Val Thr Pro Ala Arg Phe
            340                 345                 350         
Pro Pro Ala Gln Val Lys Pro Glu Pro Gly Glu Ser Thr Gly Ala Pro
        355                 360                 365             
Gly Pro His Glu Ala Ser Gln Asp Arg Ser Leu Asp Leu Thr Val Lys
    370                 375                 380                 
Glu Pro Ser Asn Glu Ser Asn Gly His Ala Val Pro Ala Asn Ser Ser
385                 390                 395                 400 
Leu Leu Ser Ser Leu Met Asn Lys Met Ser Gln Gly Asn Pro Gly Leu
                405                 410                 415     
Gly Ser Leu Leu Asn Ile Lys Ala Glu Ala Glu Gly Ser Pro Ala Ala
            420                 425                 430         
Glu Pro Ser Pro Phe Leu Gly Lys Ala Val Lys Ala Leu Val Gln Glu
        435                 440                 445             
Lys Leu Ala Glu Pro Trp Lys Val Tyr Leu Arg Arg Phe Gly Thr Lys
    450                 455                 460                 
Asp Phe Cys Asp Gly Gln Cys Asp Phe Leu His Lys Ala His Phe His
465                 470                 475                 480 
Cys Val Val Glu Glu Cys Gly Ala Leu Phe Ser Thr Leu Asp Gly Ala
                485                 490                 495     
Ile Lys His Ala Asn Phe His Phe Arg Thr Glu Gly Gly Ala Ala Lys
            500                 505                 510         
Gly Asn Thr Glu Ala Ala Phe Pro Ala Ser Ala Ala Glu Thr Lys Pro
        515                 520                 525             
Pro Met Ala Pro Ser Ser Pro Pro Val Pro Pro Val Thr Thr Ala Thr
    530                 535                 540                 
Val Ser Ser Leu Glu Gly Pro Ala Pro Ser Pro Ala Ser Val Pro Ser
545                 550                 555                 560 
Thr Pro Thr Leu Leu Ala Trp Lys Gln Leu Ala Ser Thr Ile Pro Gln
                565                 570                 575     
Met Pro Gln Ile Pro Ala Ser Val Pro His Leu Pro Ala Ser Pro Leu
            580                 585                 590         
Ala Thr Thr Ser Leu Glu Asn Ala Lys Pro Gln Val Lys Pro Gly Phe
        595                 600                 605             
Leu Gln Phe Gln Glu Lys
    610                 


<210> 59
<211> 437
<212> PRT
<213> Homo sapiens

<400> 59
Met Thr Gln Phe Leu Pro Pro Asn Leu Leu Ala Leu Phe Ala Pro Arg
 1               5                  10                  15      
Asp Pro Ile Pro Tyr Leu Pro Pro Leu Glu Lys Leu Pro His Glu Lys
            20                  25                  30          
His His Asn Gln Pro Tyr Cys Gly Ile Ala Pro Tyr Ile Arg Glu Phe
        35                  40                  45              
Glu Asp Pro Arg Asp Ala Pro Pro Pro Thr Arg Ala Glu Thr Arg Glu
    50                  55                  60                  
Glu Arg Met Glu Arg Lys Arg Arg Glu Lys Ile Glu Arg Arg Gln Gln
65                  70                  75                  80  
Glu Val Glu Thr Glu Leu Lys Met Trp Asp Pro His Asn Asp Pro Asn
                85                  90                  95      
Ala Gln Gly Asp Ala Phe Lys Thr Leu Phe Val Ala Arg Val Asn Tyr
            100                 105                 110         
Asp Thr Thr Glu Ser Lys Leu Arg Arg Glu Phe Glu Val Tyr Gly Pro
        115                 120                 125             
Ile Lys Arg Ile His Met Val Tyr Ser Lys Arg Ser Gly Lys Pro Arg
    130                 135                 140                 
Gly Tyr Ala Phe Ile Glu Tyr Glu His Glu Arg Asp Met His Ser Ala
145                 150                 155                 160 
Tyr Lys His Ala Asp Gly Lys Lys Ile Asp Gly Arg Arg Val Leu Val
                165                 170                 175     
Asp Val Glu Arg Gly Arg Thr Val Lys Gly Trp Arg Pro Arg Arg Leu
            180                 185                 190         
Gly Gly Gly Leu Gly Gly Thr Arg Arg Gly Gly Ala Asp Val Asn Ile
        195                 200                 205             
Arg His Ser Gly Arg Asp Asp Thr Ser Arg Tyr Asp Glu Arg Pro Gly
    210                 215                 220                 
Pro Ser Pro Leu Pro His Arg Asp Arg Asp Arg Asp Arg Glu Arg Glu
225                 230                 235                 240 
Arg Arg Glu Arg Ser Arg Glu Arg Asp Lys Glu Arg Glu Arg Arg Arg
                245                 250                 255     
Ser Arg Ser Arg Asp Arg Arg Arg Arg Ser Arg Ser Arg Asp Lys Glu
            260                 265                 270         
Glu Arg Arg Arg Ser Arg Glu Arg Ser Lys Asp Lys Asp Arg Asp Arg
        275                 280                 285             
Lys Arg Arg Ser Ser Arg Ser Arg Glu Arg Ala Arg Arg Glu Arg Glu
    290                 295                 300                 
Arg Lys Glu Glu Leu Arg Gly Gly Gly Gly Asp Met Ala Glu Pro Ser
305                 310                 315                 320 
Glu Ala Gly Asp Ala Pro Pro Asp Asp Gly Pro Pro Gly Glu Leu Gly
                325                 330                 335     
Pro Asp Gly Pro Asp Gly Pro Glu Glu Lys Gly Arg Asp Arg Asp Arg
            340                 345                 350         
Glu Arg Arg Arg Ser His Arg Ser Glu Arg Glu Arg Arg Arg Asp Arg
        355                 360                 365             
Asp Arg Asp Arg Asp Arg Asp Arg Glu His Lys Arg Gly Glu Arg Gly
    370                 375                 380                 
Ser Glu Arg Gly Arg Asp Glu Ala Arg Gly Gly Gly Gly Gly Gln Asp
385                 390                 395                 400 
Asn Gly Leu Glu Gly Leu Gly Asn Asp Ser Arg Asp Met Tyr Met Glu
                405                 410                 415     
Ser Glu Gly Gly Asp Gly Tyr Leu Ala Pro Glu Asn Gly Tyr Leu Met
            420                 425                 430         
Glu Ala Ala Pro Glu
        435         


<210> 60
<211> 159
<212> PRT
<213> Homo sapiens

<400> 60
Met Pro Lys Phe Tyr Cys Asp Tyr Cys Asp Thr Tyr Leu Thr His Asp
 1               5                  10                  15      
Ser Pro Ser Val Arg Lys Thr His Cys Ser Gly Arg Lys His Lys Glu
            20                  25                  30          
Asn Val Lys Asp Tyr Tyr Gln Lys Trp Met Glu Glu Gln Ala Gln Ser
        35                  40                  45              
Leu Ile Asp Lys Thr Thr Ala Ala Phe Gln Gln Gly Lys Ile Pro Pro
    50                  55                  60                  
Thr Pro Phe Ser Ala Pro Pro Pro Ala Gly Ala Met Ile Pro Pro Pro
65                  70                  75                  80  
Pro Ser Leu Pro Gly Pro Pro Arg Pro Gly Met Met Pro Ala Pro His
                85                  90                  95      
Met Gly Gly Pro Pro Met Met Pro Met Met Gly Pro Pro Pro Pro Gly
            100                 105                 110         
Met Met Pro Val Gly Pro Ala Pro Gly Met Arg Pro Pro Met Gly Gly
        115                 120                 125             
His Met Pro Met Met Pro Gly Pro Pro Met Met Arg Pro Pro Ala Arg
    130                 135                 140                 
Pro Met Met Val Pro Thr Arg Pro Gly Met Thr Arg Pro Asp Arg
145                 150                 155                 


<210> 61
<211> 181
<212> PRT
<213> Homo sapiens

<400> 61
Met Glu Ser Lys Glu Pro Gln Leu Lys Gly Ile Val Thr Arg Leu Phe
 1               5                  10                  15      
Ser Gln Gln Gly Tyr Phe Leu Gln Met His Pro Asp Gly Thr Ile Asp
            20                  25                  30          
Gly Thr Lys Asp Glu Asn Ser Asp Tyr Thr Leu Phe Asn Leu Ile Pro
        35                  40                  45              
Val Gly Leu Arg Val Val Ala Ile Gln Gly Val Lys Ala Ser Leu Tyr
    50                  55                  60                  
Val Ala Met Asn Gly Glu Gly Tyr Leu Tyr Ser Ser Asp Val Phe Thr
65                  70                  75                  80  
Pro Glu Cys Lys Phe Lys Glu Ser Val Phe Glu Asn Tyr Tyr Val Ile
                85                  90                  95      
Tyr Ser Ser Thr Leu Tyr Arg Gln Gln Glu Ser Gly Arg Ala Trp Phe
            100                 105                 110         
Leu Gly Leu Asn Lys Glu Gly Gln Ile Met Lys Gly Asn Arg Val Lys
        115                 120                 125             
Lys Thr Lys Pro Ser Ser His Phe Val Pro Lys Pro Ile Glu Val Cys
    130                 135                 140                 
Met Tyr Arg Glu Pro Ser Leu His Glu Ile Gly Glu Lys Gln Gly Arg
145                 150                 155                 160 
Ser Arg Lys Ser Ser Gly Thr Pro Thr Met Asn Gly Gly Lys Val Val
                165                 170                 175     
Asn Gln Asp Ser Thr
            180     


<210> 62
<211> 78
<212> PRT
<213> Homo sapiens

<400> 62
Met Ser Glu Val Leu Pro Tyr Gly Asp Glu Lys Leu Ser Pro Tyr Gly
 1               5                  10                  15      
Asp Gly Gly Asp Val Gly Gln Ile Phe Ser Cys Arg Leu Gln Asp Thr
            20                  25                  30          
Asn Asn Phe Phe Gly Ala Gly Gln Asn Lys Arg Pro Pro Lys Leu Gly
        35                  40                  45              
Gln Ile Gly Arg Ser Lys Arg Val Val Ile Glu Asp Asp Arg Ile Asp
    50                  55                  60                  
Asp Val Leu Lys Asn Met Thr Asp Lys Ala Pro Pro Gly Val
65                  70                  75              


<210> 63
<211> 471
<212> PRT
<213> Homo sapiens

<400> 63
Met Glu Leu Gly Leu Arg Trp Val Phe Leu Val Ala Ile Leu Glu Gly
 1               5                  10                  15      
Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys
            20                  25                  30          
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe
        35                  40                  45              
Ser Ser Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
    50                  55                  60                  
Glu Trp Val Ser Ser Met Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala
65                  70                  75                  80  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn
                85                  90                  95      
Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
            100                 105                 110         
Tyr Tyr Cys Ala Arg Asp Leu Arg Gln Leu Thr Ser Tyr Trp Tyr Phe
        115                 120                 125             
Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
    130                 135                 140                 
Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser
145                 150                 155                 160 
Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu
                165                 170                 175     
Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His
            180                 185                 190         
Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
        195                 200                 205             
Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
    210                 215                 220                 
Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu
225                 230                 235                 240 
Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro
                245                 250                 255     
Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
            260                 265                 270         
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
        275                 280                 285             
Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp
    290                 295                 300                 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr
305                 310                 315                 320 
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
                325                 330                 335     
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu
            340                 345                 350         
Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
        355                 360                 365             
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys
    370                 375                 380                 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
385                 390                 395                 400 
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
                405                 410                 415     
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
            420                 425                 430         
Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
        435                 440                 445             
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
    450                 455                 460                 
Leu Ser Leu Ser Pro Gly Lys
465                 470     


<210> 64
<211> 326
<212> PRT
<213> Homo sapiens

<400> 64
Met Pro Pro Met Pro Val Ala Ser Val Ala Pro Ser Ala Ser Met Pro
 1               5                  10                  15      
Gly Ser His Leu Pro Pro Leu Tyr Leu Asp Gly His Val Phe Ala Ser
            20                  25                  30          
Gln Pro Arg Leu Val Pro Gln Thr Ile Pro Gln Gln Gln Ser Tyr Gln
        35                  40                  45              
Gln Ala Ala Ala Ala Gln Gln Ile Pro Ile Ser Leu His Thr Ser Leu
    50                  55                  60                  
Gln Ala Gln Ala Gln Leu Gly Leu Arg Gly Gly Leu Pro Val Ser Gln
65                  70                  75                  80  
Ser Gln Glu Ile Phe Ser Ser Leu Gln Pro Phe Arg Ser Gln Val Tyr
                85                  90                  95      
Met His Pro Ser Leu Ser Pro Pro Ser Thr Met Ile Leu Ser Gly Gly
            100                 105                 110         
Thr Ala Leu Lys Pro Pro Tyr Ser Ala Phe Pro Gly Met Gln Pro Leu
        115                 120                 125             
Glu Met Val Lys Pro Gln Ser Gly Ser Pro Tyr Gln Pro Met Ser Gly
    130                 135                 140                 
Asn Gln Ala Leu Val Tyr Glu Gly Gln Leu Ser Gln Ala Ala Gly Leu
145                 150                 155                 160 
Gly Ala Ser Gln Met Leu Asp Ser Gln Leu Pro Gln Leu Thr Met Pro
                165                 170                 175     
Leu Pro Arg Tyr Gly Ser Gly Gln Gln Pro Leu Ile Leu Pro Gln Ser
            180                 185                 190         
Ile Gln Leu Pro Pro Gly Gln Ser Leu Ser Val Gly Ala Pro Arg Arg
        195                 200                 205             
Ile Pro Pro Pro Gly Ser Gln Pro Pro Val Leu Asn Thr Ser Arg Glu
    210                 215                 220                 
Pro Ser Gln Met Glu Met Lys Gly Phe His Phe Ala Asp Ser Lys Gln
225                 230                 235                 240 
Asn Val Pro Ser Gly Gly Pro Val Pro Ser Pro Gln Thr Tyr Arg Pro
                245                 250                 255     
Ser Ser Ala Ser Pro Ser Gly Lys Pro Ser Gly Ser Ala Val Asn Met
            260                 265                 270         
Gly Ser Val Gln Gly His Tyr Val Gln Gln Ala Lys Gln Arg Val Asp
        275                 280                 285             
Glu Lys Pro Ser Leu Gly Ala Val Lys Leu Gln Glu Ala Pro Ser Ala
    290                 295                 300                 
Ala Ser Gln Met Lys Arg Thr Gly Ala Ile Lys Pro Arg Ala Val Lys
305                 310                 315                 320 
Val Glu Glu Ser Lys Ala
                325     


<210> 65
<211> 536
<212> PRT
<213> Homo sapiens

<400> 65
Met Thr Lys Lys Thr Arg Asp Leu Arg Arg Gln Leu Arg Lys Ala Val
 1               5                  10                  15      
Met Asp His Val Ser Asp Ser Phe Leu Glu Thr Asn Val Pro Leu Leu
            20                  25                  30          
Val Leu Ile Glu Ala Ala Lys Asn Gly Asn Glu Lys Glu Val Lys Glu
        35                  40                  45              
Tyr Ala Gln Val Phe Arg Glu His Ala Asn Lys Leu Ile Glu Val Ala
    50                  55                  60                  
Asn Leu Ala Cys Ser Ile Ser Asn Asn Glu Glu Gly Val Lys Leu Val
65                  70                  75                  80  
Arg Met Ser Ala Ser Gln Leu Glu Ala Leu Cys Pro Gln Val Ile Asn
                85                  90                  95      
Ala Ala Leu Ala Leu Ala Ala Lys Pro Gln Ser Lys Leu Ala Gln Glu
            100                 105                 110         
Asn Met Asp Leu Phe Lys Glu Gln Trp Glu Lys Gln Val Arg Val Leu
        115                 120                 125             
Thr Asp Ala Val Asp Asp Ile Thr Ser Ile Asp Asp Phe Leu Ala Val
    130                 135                 140                 
Ser Glu Asn His Ile Leu Glu Asp Val Asn Lys Cys Val Ile Ala Leu
145                 150                 155                 160 
Gln Glu Lys Asp Val Asp Gly Leu Asp Arg Thr Ala Gly Ala Ile Arg
                165                 170                 175     
Gly Arg Ala Ala Arg Val Ile His Val Val Thr Ser Glu Met Asp Asn
            180                 185                 190         
Tyr Glu Pro Gly Val Tyr Thr Glu Lys Val Leu Glu Ala Thr Lys Leu
        195                 200                 205             
Leu Ser Asn Thr Val Met Pro Arg Phe Thr Glu Gln Val Glu Ala Ala
    210                 215                 220                 
Val Glu Ala Leu Ser Ser Asp Pro Ala Gln Pro Met Asp Glu Asn Glu
225                 230                 235                 240 
Phe Ile Asp Ala Ser Arg Leu Val Tyr Asp Gly Ile Arg Asp Ile Arg
                245                 250                 255     
Lys Ala Val Leu Met Ile Arg Thr Pro Glu Glu Leu Asp Asp Ser Asp
            260                 265                 270         
Phe Glu Thr Glu Asp Phe Asp Val Arg Ser Arg Thr Ser Val Gln Thr
        275                 280                 285             
Glu Asp Asp Gln Leu Ile Ala Gly Gln Ser Ala Arg Ala Ile Met Ala
    290                 295                 300                 
Gln Leu Pro Gln Glu Gln Lys Ala Lys Ile Ala Glu Gln Val Ala Ser
305                 310                 315                 320 
Phe Gln Glu Glu Lys Ser Lys Leu Asp Ala Glu Val Ser Lys Trp Asp
                325                 330                 335     
Asp Ser Gly Asn Asp Ile Ile Val Leu Ala Lys Gln Met Cys Met Ile
            340                 345                 350         
Met Met Glu Met Thr Asp Phe Thr Arg Gly Lys Gly Pro Leu Lys Asn
        355                 360                 365             
Thr Ser Asp Val Ile Ser Ala Ala Lys Lys Ile Ala Glu Ala Gly Ser
    370                 375                 380                 
Arg Met Asp Lys Leu Gly Arg Thr Ile Ala Asp His Cys Pro Asp Ser
385                 390                 395                 400 
Ala Cys Lys Gln Asp Leu Leu Ala Tyr Leu Gln Arg Ile Ala Leu Tyr
                405                 410                 415     
Cys His Gln Leu Asn Ile Cys Ser Lys Val Lys Ala Glu Val Gln Asn
            420                 425                 430         
Leu Gly Gly Glu Leu Val Val Ser Gly Val Asp Ser Ala Met Ser Leu
        435                 440                 445             
Ile Gln Ala Ala Lys Asn Leu Met Asn Ala Val Val Gln Thr Val Lys
    450                 455                 460                 
Ala Ser Tyr Val Ala Ser Thr Lys Tyr Gln Lys Ser Gln Gly Met Ala
465                 470                 475                 480 
Ser Leu Asn Leu Pro Ala Val Ser Trp Lys Met Lys Ala Pro Glu Lys
                485                 490                 495     
Lys Pro Leu Val Lys Arg Glu Lys Gln Asp Glu Thr Gln Thr Lys Ile
            500                 505                 510         
Lys Arg Ala Ser Gln Lys Lys His Val Asn Pro Val Gln Ala Leu Ser
        515                 520                 525             
Glu Phe Lys Ala Met Asp Ser Ile
    530                 535     


<210> 66
<211> 268
<212> PRT
<213> Homo sapiens

<400> 66
Met Ala Val Asn Val Tyr Ser Thr Ser Val Thr Ser Asp Asn Leu Ser
 1               5                  10                  15      
Arg His Asp Met Leu Ala Trp Ile Asn Glu Ser Leu Gln Leu Asn Leu
            20                  25                  30          
Thr Lys Ile Glu Gln Leu Cys Ser Gly Ala Ala Tyr Cys Gln Phe Met
        35                  40                  45              
Asp Met Leu Phe Pro Gly Ser Ile Ala Leu Lys Lys Val Lys Phe Gln
    50                  55                  60                  
Ala Lys Leu Glu His Glu Tyr Ile Gln Asn Phe Lys Ile Leu Gln Ala
65                  70                  75                  80  
Gly Phe Lys Arg Met Gly Val Asp Lys Ile Ile Pro Val Asp Lys Leu
                85                  90                  95      
Val Lys Gly Lys Phe Gln Asp Asn Phe Glu Phe Val Gln Trp Phe Lys
            100                 105                 110         
Lys Phe Phe Asp Ala Asn Tyr Asp Gly Lys Asp Tyr Asp Pro Val Ala
        115                 120                 125             
Ala Arg Gln Gly Gln Glu Thr Ala Val Ala Pro Ser Leu Val Ala Pro
    130                 135                 140                 
Ala Leu Asn Lys Pro Lys Lys Pro Leu Thr Ser Ser Ser Ala Ala Pro
145                 150                 155                 160 
Gln Arg Pro Ile Ser Thr Gln Arg Thr Ala Ala Ala Pro Lys Ala Gly
                165                 170                 175     
Pro Gly Val Val Arg Lys Asn Pro Gly Val Gly Asn Gly Asp Asp Glu
            180                 185                 190         
Ala Ala Glu Leu Met Gln Gln Val Asn Val Leu Lys Leu Thr Val Glu
        195                 200                 205             
Asp Leu Glu Lys Glu Arg Asp Phe Tyr Phe Gly Lys Leu Arg Asn Ile
    210                 215                 220                 
Glu Leu Ile Cys Gln Glu Asn Glu Gly Glu Asn Asp Pro Val Leu Gln
225                 230                 235                 240 
Arg Ile Val Asp Ile Leu Tyr Ala Thr Asp Glu Gly Phe Val Ile Pro
                245                 250                 255     
Asp Glu Gly Gly Pro Gln Glu Glu Gln Glu Glu Tyr
            260                 265             


<210> 67
<211> 254
<212> PRT
<213> Homo sapiens

<400> 67
Met Asp Gly Gly Asp Asp Gly Asn Leu Ile Ile Lys Lys Arg Phe Val
 1               5                  10                  15      
Ser Glu Ala Glu Leu Asp Glu Arg Arg Lys Arg Arg Gln Glu Glu Trp
            20                  25                  30          
Glu Lys Val Arg Lys Pro Glu Asp Pro Glu Glu Cys Pro Glu Glu Val
        35                  40                  45              
Tyr Asp Pro Arg Ser Leu Tyr Glu Arg Leu Gln Glu Gln Lys Asp Arg
    50                  55                  60                  
Lys Gln Gln Glu Tyr Glu Glu Gln Phe Lys Phe Lys Asn Met Val Arg
65                  70                  75                  80  
Gly Leu Asp Glu Asp Glu Thr Asn Phe Leu Asp Glu Val Ser Arg Gln
                85                  90                  95      
Gln Glu Leu Ile Glu Lys Gln Arg Arg Glu Glu Glu Leu Lys Glu Leu
            100                 105                 110         
Lys Glu Tyr Arg Asn Asn Leu Lys Lys Val Gly Ile Ser Gln Glu Asn
        115                 120                 125             
Lys Lys Glu Val Glu Lys Lys Leu Thr Val Lys Pro Ile Glu Thr Lys
    130                 135                 140                 
Asn Lys Phe Ser Gln Ala Lys Leu Leu Ala Gly Ala Val Lys His Lys
145                 150                 155                 160 
Ser Ser Glu Ser Gly Asn Ser Val Lys Arg Leu Lys Pro Asp Pro Glu
                165                 170                 175     
Pro Asp Asp Lys Asn Gln Glu Pro Ser Ser Cys Lys Ser Leu Gly Asn
            180                 185                 190         
Thr Ser Leu Ser Gly Pro Ser Ile His Cys Pro Ser Ala Ala Val Cys
        195                 200                 205             
Ile Gly Ile Leu Pro Gly Leu Gly Ala Tyr Ser Gly Ser Ser Asp Ser
    210                 215                 220                 
Glu Ser Ser Ser Asp Ser Glu Gly Thr Ile Asn Ala Thr Gly Lys Ile
225                 230                 235                 240 
Val Ser Ser Ile Phe Arg Thr Asn Thr Phe Leu Glu Ala Pro
                245                 250                 


<210> 68
<211> 466
<212> PRT
<213> Homo sapiens

<400> 68
Met Gly Trp Ile Thr Glu Asp Leu Ile Arg Arg Asn Ala Glu His Asn
 1               5                  10                  15      
Asp Cys Val Ile Phe Ser Leu Glu Glu Leu Ser Leu His Gln Gln Glu
            20                  25                  30          
Ile Glu Arg Leu Glu His Ile Asp Lys Trp Cys Arg Asp Leu Lys Ile
        35                  40                  45              
Leu Tyr Leu Gln Asn Asn Leu Ile Gly Lys Ile Glu Asn Val Ser Lys
    50                  55                  60                  
Leu Lys Lys Leu Glu Tyr Leu Asn Leu Ala Leu Asn Asn Ile Glu Lys
65                  70                  75                  80  
Ile Glu Asn Leu Glu Gly Cys Glu Glu Leu Ala Lys Leu Asp Leu Thr
                85                  90                  95      
Val Asn Phe Ile Gly Glu Leu Ser Ser Ile Lys Asn Leu Gln His Asn
            100                 105                 110         
Ile His Leu Lys Glu Leu Phe Leu Met Gly Asn Pro Cys Ala Ser Phe
        115                 120                 125             
Asp His Tyr Arg Glu Phe Val Val Ala Thr Leu Pro Gln Leu Lys Trp
    130                 135                 140                 
Leu Asp Gly Lys Glu Ile Glu Pro Ser Glu Arg Ile Lys Ala Leu Gln
145                 150                 155                 160 
Asp Tyr Ser Val Ile Glu Pro Gln Ile Arg Glu Gln Glu Lys Asp His
                165                 170                 175     
Cys Leu Lys Arg Ala Lys Leu Lys Glu Glu Ala Gln Arg Lys His Gln
            180                 185                 190         
Glu Glu Asp Lys Asn Glu Asp Lys Arg Ser Asn Ala Gly Phe Asp Gly
        195                 200                 205             
Arg Trp Tyr Thr Asp Ile Asn Ala Thr Leu Ser Ser Leu Glu Ser Lys
    210                 215                 220                 
Asp His Leu Gln Ala Pro Asp Thr Glu Glu His Asn Thr Lys Lys Leu
225                 230                 235                 240 
Asp Asn Ser Glu Asp Asp Leu Glu Phe Trp Asn Lys Pro Cys Leu Phe
                245                 250                 255     
Thr Pro Glu Ser Arg Leu Glu Thr Leu Arg His Met Glu Lys Gln Arg
            260                 265                 270         
Lys Lys Gln Glu Lys Leu Ser Glu Lys Lys Lys Lys Val Lys Pro Pro
        275                 280                 285             
Arg Thr Leu Ile Thr Glu Asp Gly Lys Ala Leu Asn Val Asn Glu Pro
    290                 295                 300                 
Lys Ile Asp Phe Ser Leu Lys Asp Asn Glu Lys Gln Ile Ile Leu Asp
305                 310                 315                 320 
Leu Ala Val Tyr Arg Tyr Met Asp Thr Ser Leu Ile Asp Val Asp Val
                325                 330                 335     
Gln Pro Thr Tyr Val Arg Val Met Ile Lys Gly Lys Pro Phe Gln Leu
            340                 345                 350         
Val Leu Pro Ala Glu Val Lys Pro Asp Ser Ser Ser Ala Lys Arg Ser
        355                 360                 365             
Gln Thr Thr Gly His Leu Val Ile Cys Met Pro Lys Val Gly Glu Val
    370                 375                 380                 
Ile Thr Gly Gly Gln Arg Ala Phe Lys Ser Met Lys Thr Thr Ser Asp
385                 390                 395                 400 
Arg Ser Arg Glu Gln Thr Asn Thr Arg Ser Lys His Met Glu Lys Leu
                405                 410                 415     
Glu Val Asp Pro Ser Lys His Ser Phe Pro Asp Val Thr Asn Ile Val
            420                 425                 430         
Gln Glu Lys Lys His Thr Pro Arg Arg Arg Pro Glu Pro Lys Ile Ile
        435                 440                 445             
Pro Ser Glu Glu Asp Pro Thr Phe Glu Asp Asn Pro Glu Val Pro Pro
    450                 455                 460                 
Leu Ile
465     


<210> 69
<211> 545
<212> PRT
<213> Homo sapiens

<400> 69
Met Ser Asn Asn Gly Leu Asp Ile Gln Asp Lys Pro Pro Ala Pro Pro
 1               5                  10                  15      
Met Arg Asn Thr Ser Thr Met Ile Gly Ala Gly Ser Lys Asp Ala Gly
            20                  25                  30          
Thr Leu Asn His Gly Ser Lys Pro Leu Pro Pro Asn Pro Glu Glu Lys
        35                  40                  45              
Lys Lys Lys Asp Arg Phe Tyr Arg Ser Ile Leu Pro Gly Asp Lys Thr
    50                  55                  60                  
Asn Lys Lys Lys Glu Lys Glu Arg Pro Glu Ile Ser Leu Pro Ser Asp
65                  70                  75                  80  
Phe Glu His Thr Ile His Val Gly Phe Asp Ala Val Thr Gly Glu Phe
                85                  90                  95      
Thr Gly Met Pro Glu Gln Trp Ala Arg Leu Leu Gln Thr Ser Asn Ile
            100                 105                 110         
Thr Lys Ser Glu Gln Lys Lys Asn Pro Gln Ala Val Leu Asp Val Leu
        115                 120                 125             
Glu Phe Tyr Asn Ser Lys Lys Thr Ser Asn Ser Gln Lys Tyr Met Ser
    130                 135                 140                 
Phe Thr Asp Lys Ser Ala Glu Asp Tyr Asn Ser Ser Asn Ala Leu Asn
145                 150                 155                 160 
Val Lys Ala Val Ser Glu Thr Pro Ala Val Pro Pro Val Ser Glu Asp
                165                 170                 175     
Glu Asp Asp Asp Asp Asp Asp Ala Thr Pro Pro Pro Val Ile Ala Pro
            180                 185                 190         
Arg Pro Glu His Thr Lys Ser Val Tyr Thr Arg Ser Val Ile Glu Pro
        195                 200                 205             
Leu Pro Val Thr Pro Thr Arg Asp Val Ala Thr Ser Pro Ile Ser Pro
    210                 215                 220                 
Thr Glu Asn Asn Thr Thr Pro Pro Asp Ala Leu Thr Arg Asn Thr Glu
225                 230                 235                 240 
Lys Gln Lys Lys Lys Pro Lys Met Ser Asp Glu Glu Ile Leu Glu Lys
                245                 250                 255     
Leu Arg Ser Ile Val Ser Val Gly Asp Pro Lys Lys Lys Tyr Thr Arg
            260                 265                 270         
Phe Glu Lys Ile Gly Gln Gly Ala Ser Gly Thr Val Tyr Thr Ala Met
        275                 280                 285             
Asp Val Ala Thr Gly Gln Glu Val Ala Ile Lys Gln Met Asn Leu Gln
    290                 295                 300                 
Gln Gln Pro Lys Lys Glu Leu Ile Ile Asn Glu Ile Leu Val Met Arg
305                 310                 315                 320 
Glu Asn Lys Asn Pro Asn Ile Val Asn Tyr Leu Asp Ser Tyr Leu Val
                325                 330                 335     
Gly Asp Glu Leu Trp Val Val Met Glu Tyr Leu Ala Gly Gly Ser Leu
            340                 345                 350         
Thr Asp Val Val Thr Glu Thr Cys Met Asp Glu Gly Gln Ile Ala Ala
        355                 360                 365             
Val Cys Arg Glu Cys Leu Gln Ala Leu Glu Phe Leu His Ser Asn Gln
    370                 375                 380                 
Val Ile His Arg Asp Ile Lys Ser Asp Asn Ile Leu Leu Gly Met Asp
385                 390                 395                 400 
Gly Ser Val Lys Leu Thr Asp Phe Gly Phe Cys Ala Gln Ile Thr Pro
                405                 410                 415     
Glu Gln Ser Lys Arg Ser Thr Met Val Gly Thr Pro Tyr Trp Met Ala
            420                 425                 430         
Pro Glu Val Val Thr Arg Lys Ala Tyr Gly Pro Lys Val Asp Ile Trp
        435                 440                 445             
Ser Leu Gly Ile Met Ala Ile Glu Met Ile Glu Gly Glu Pro Pro Tyr
    450                 455                 460                 
Leu Asn Glu Asn Pro Leu Arg Ala Leu Tyr Leu Ile Ala Thr Asn Gly
465                 470                 475                 480 
Thr Pro Glu Leu Gln Asn Pro Glu Lys Leu Ser Ala Ile Phe Arg Asp
                485                 490                 495     
Phe Leu Asn Arg Cys Leu Glu Met Asp Val Glu Lys Arg Gly Ser Ala
            500                 505                 510         
Lys Glu Leu Leu Gln His Gln Phe Leu Lys Ile Ala Lys Pro Leu Ser
        515                 520                 525             
Ser Leu Thr Pro Leu Ile Ala Ala Ala Lys Glu Ala Thr Lys Asn Asn
    530                 535                 540                 
His
545 


<210> 70
<211> 145
<212> PRT
<213> Homo sapiens

<400> 70
Met Trp Ser Phe Leu Pro Gly Ala Glu Ser Val Ser Met Gly Pro Val
 1               5                  10                  15      
Pro Gly Val Ser Ser Leu Gly Ala Cys Trp Thr His Asp Gln Asp Ser
            20                  25                  30          
Gly Arg Ala Glu Asp Arg Pro Gln Ala Pro Arg Ile Thr Gln Tyr Thr
        35                  40                  45              
Trp Val Leu Ser Phe Leu Phe Thr Glu Lys Pro Gln Thr Arg Ser Thr
    50                  55                  60                  
Ser Pro Ile Ser His Gln Gly Gln Pro Gln Thr Thr Arg Ala Leu Ser
65                  70                  75                  80  
Leu Arg Gln Pro Gln His Pro Ser Ala Pro Ala Ser Gly Arg Pro Arg
                85                  90                  95      
Pro Pro His Ser Ser Gly Pro Asp Leu Ala Glu Ala Ala Pro Val Val
            100                 105                 110         
Asp Gln Ala Ser Gln Ala Ala Gly Arg Ala Ser Ser Gly Leu Gly Leu
        115                 120                 125             
Trp Glu Gln Ala Ser Val Ser Gln Gly Phe Arg Asn Ala Ala Phe Glu
    130                 135                 140                 
Ala
145 


<210> 71
<211> 426
<212> PRT
<213> Homo sapiens

<400> 71
Met Ala His Leu Arg Gly Phe Ala Asn Gln His Ser Arg Val Asp Pro
 1               5                  10                  15      
Glu Glu Leu Phe Thr Lys Leu Asp Arg Ile Gly Lys Gly Ser Phe Gly
            20                  25                  30          
Glu Val Tyr Lys Gly Ile Asp Asn His Thr Lys Glu Val Val Ala Ile
        35                  40                  45              
Lys Ile Ile Asp Leu Glu Glu Ala Glu Asp Glu Ile Glu Asp Ile Gln
    50                  55                  60                  
Gln Glu Ile Thr Val Leu Ser Gln Cys Asp Ser Pro Tyr Ile Thr Arg
65                  70                  75                  80  
Tyr Phe Gly Ser Tyr Leu Lys Ser Thr Lys Leu Trp Ile Ile Met Glu
                85                  90                  95      
Tyr Leu Gly Gly Gly Ser Ala Leu Asp Leu Leu Lys Pro Gly Pro Leu
            100                 105                 110         
Glu Glu Thr Tyr Ile Ala Thr Ile Leu Arg Glu Ile Leu Lys Gly Leu
        115                 120                 125             
Asp Tyr Leu His Ser Glu Arg Lys Ile His Arg Asp Ile Lys Ala Ala
    130                 135                 140                 
Asn Val Leu Leu Ser Glu Gln Gly Asp Val Lys Leu Ala Asp Phe Gly
145                 150                 155                 160 
Val Ala Gly Gln Leu Thr Asp Thr Gln Ile Lys Arg Asn Thr Phe Val
                165                 170                 175     
Gly Thr Pro Phe Trp Met Ala Pro Glu Val Ile Lys Gln Ser Ala Tyr
            180                 185                 190         
Asp Phe Lys Ala Asp Ile Trp Ser Leu Gly Ile Thr Ala Ile Glu Leu
        195                 200                 205             
Ala Lys Gly Glu Pro Pro Asn Ser Asp Leu His Pro Met Arg Val Leu
    210                 215                 220                 
Phe Leu Ile Pro Lys Asn Ser Pro Pro Thr Leu Glu Gly Gln His Ser
225                 230                 235                 240 
Lys Pro Phe Lys Glu Phe Val Glu Ala Cys Leu Asn Lys Asp Pro Arg
                245                 250                 255     
Phe Arg Pro Thr Ala Lys Glu Leu Leu Lys His Lys Phe Ile Thr Arg
            260                 265                 270         
Tyr Thr Lys Lys Thr Ser Phe Leu Thr Glu Leu Ile Asp Arg Tyr Lys
        275                 280                 285             
Arg Trp Lys Ser Glu Gly His Gly Glu Glu Ser Ser Ser Glu Asp Ser
    290                 295                 300                 
Asp Ile Asp Gly Glu Ala Glu Asp Gly Glu Gln Gly Pro Ile Trp Thr
305                 310                 315                 320 
Phe Pro Pro Thr Ile Arg Pro Ser Pro His Ser Lys Leu His Lys Gly
                325                 330                 335     
Thr Ala Leu His Ser Ser Gln Lys Pro Ala Glu Pro Val Lys Arg Gln
            340                 345                 350         
Pro Arg Ser Gln Cys Leu Ser Thr Leu Val Arg Pro Val Phe Gly Glu
        355                 360                 365             
Leu Lys Glu Lys His Lys Gln Ser Gly Gly Ser Val Gly Ala Leu Glu
    370                 375                 380                 
Glu Leu Glu Asn Ala Phe Ser Leu Ala Glu Glu Ser Cys Pro Gly Ile
385                 390                 395                 400 
Ser Asp Lys Leu Met Val His Leu Val Glu Arg Val Gln Arg Phe Ser
                405                 410                 415     
His Asn Arg Asn His Leu Thr Ser Thr Arg
            420                 425     


<210> 72
<211> 194
<212> PRT
<213> Homo sapiens

<400> 72
Met Ala Lys Gln Lys Arg Lys Val Pro Glu Val Thr Glu Lys Lys Asn
 1               5                  10                  15      
Lys Lys Leu Lys Lys Ala Ser Ala Glu Gly Pro Leu Leu Gly Pro Glu
            20                  25                  30          
Ala Ala Pro Ser Gly Glu Gly Ala Gly Ser Lys Gly Glu Ala Val Leu
        35                  40                  45              
Arg Pro Gly Leu Asp Ala Glu Pro Glu Leu Ser Pro Glu Glu Gln Arg
    50                  55                  60                  
Val Leu Glu Arg Lys Leu Lys Lys Glu Arg Lys Lys Glu Glu Arg Gln
65                  70                  75                  80  
Arg Leu Arg Glu Ala Gly Leu Val Ala Gln His Pro Pro Ala Arg Arg
                85                  90                  95      
Ser Gly Ala Glu Leu Ala Leu Asp Tyr Leu Cys Arg Trp Ala Gln Lys
            100                 105                 110         
His Lys Asn Trp Arg Phe Gln Lys Thr Arg Gln Thr Trp Leu Leu Leu
        115                 120                 125             
His Met Tyr Asp Ser Asp Lys Val Pro Asp Glu His Phe Ser Thr Leu
    130                 135                 140                 
Leu Ala Tyr Leu Glu Gly Leu Gln Gly Arg Ala Arg Glu Leu Thr Val
145                 150                 155                 160 
Gln Lys Ala Glu Ala Leu Met Arg Glu Leu Asp Glu Glu Gly Ser Asp
                165                 170                 175     
Pro Pro Leu Pro Gly Arg Ala Gln Arg Ile Arg Gln Val Leu Gln Leu
            180                 185                 190         
Leu Ser
        


<210> 73
<211> 1146
<212> PRT
<213> Homo sapiens

<400> 73
Met Val Leu Gly Thr Val Leu Leu Pro Pro Asn Ser Tyr Gly Arg Asp
 1               5                  10                  15      
Gln Asp Thr Ser Leu Cys Cys Leu Cys Thr Glu Ala Ser Glu Ser Ala
            20                  25                  30          
Leu Pro Asp Leu Thr Glu Ala Leu His Arg Pro Tyr Gly Cys Asp Val
        35                  40                  45              
Glu Pro Gln Ala Leu Asn Glu Ala Ile Arg Trp Ser Ser Lys Glu Asn
    50                  55                  60                  
Leu Leu Gly Ala Thr Glu Ser Asp Pro Asn Leu Phe Val Ala Leu Tyr
65                  70                  75                  80  
Asp Phe Val Ala Ser Gly Asp Asn Thr Leu Ser Ile Thr Lys Gly Glu
                85                  90                  95      
Lys Leu Arg Val Leu Gly Tyr Asn Gln Asn Gly Glu Trp Ser Glu Val
            100                 105                 110         
Arg Ser Lys Asn Gly Gln Gly Trp Val Pro Ser Asn Tyr Ile Thr Pro
        115                 120                 125             
Val Asn Ser Leu Glu Lys His Ser Trp Tyr His Gly Pro Val Ser Arg
    130                 135                 140                 
Ser Ala Ala Glu Tyr Leu Leu Ser Ser Leu Ile Asn Gly Ser Phe Leu
145                 150                 155                 160 
Val Arg Glu Ser Glu Ser Ser Pro Gly Gln Leu Ser Ile Ser Leu Arg
                165                 170                 175     
Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile Asn Thr Thr Ala Asp Gly
            180                 185                 190         
Lys Val Tyr Val Thr Ala Glu Ser Arg Phe Ser Thr Leu Ala Glu Leu
        195                 200                 205             
Val His His His Ser Thr Val Ala Asp Gly Leu Val Thr Thr Leu His
    210                 215                 220                 
Tyr Pro Ala Pro Lys Cys Asn Lys Pro Thr Val Tyr Gly Val Ser Pro
225                 230                 235                 240 
Ile His Asp Lys Trp Glu Met Glu Arg Thr Asp Ile Thr Met Lys His
                245                 250                 255     
Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val Tyr Val Gly Val Trp Lys
            260                 265                 270         
Lys Tyr Ser Leu Thr Val Ala Val Lys Thr Leu Lys Glu Asp Thr Met
        275                 280                 285             
Glu Val Glu Glu Phe Leu Lys Glu Ala Ala Val Met Lys Glu Ile Lys
    290                 295                 300                 
His Pro Asn Leu Val Gln Leu Leu Gly Val Cys Thr Leu Glu Pro Pro
305                 310                 315                 320 
Phe Tyr Ile Val Thr Glu Tyr Met Pro Tyr Gly Asn Leu Leu Asp Tyr
                325                 330                 335     
Leu Arg Glu Cys Asn Arg Glu Glu Val Thr Ala Val Val Leu Leu Tyr
            340                 345                 350         
Met Ala Thr Gln Ile Ser Ser Ala Met Glu Tyr Leu Glu Lys Lys Asn
        355                 360                 365             
Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Leu Val Gly Glu Asn
    370                 375                 380                 
His Val Val Lys Val Ala Asp Phe Gly Leu Ser Arg Leu Met Thr Gly
385                 390                 395                 400 
Asp Thr Tyr Thr Ala His Ala Gly Ala Lys Phe Pro Ile Lys Trp Thr
                405                 410                 415     
Ala Pro Glu Ser Leu Ala Tyr Asn Thr Phe Ser Ile Lys Ser Asp Val
            420                 425                 430         
Trp Ala Phe Gly Val Leu Leu Trp Glu Ile Ala Thr Tyr Gly Met Ser
        435                 440                 445             
Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val Tyr Asp Leu Leu Glu Lys
    450                 455                 460                 
Gly Tyr Arg Met Glu Gln Pro Glu Gly Cys Pro Pro Lys Val Tyr Glu
465                 470                 475                 480 
Leu Met Arg Ala Cys Trp Lys Trp Ser Pro Ala Asp Arg Pro Ser Phe
                485                 490                 495     
Ala Glu Thr His Gln Ala Phe Glu Thr Met Phe His Asp Ser Ser Ile
            500                 505                 510         
Ser Glu Glu Val Ala Glu Glu Leu Gly Arg Ala Ala Ser Ser Ser Ser
        515                 520                 525             
Val Val Pro Tyr Leu Pro Arg Leu Pro Ile Leu Pro Ser Lys Thr Arg
    530                 535                 540                 
Thr Leu Lys Lys Gln Val Glu Asn Lys Glu Asn Ile Glu Gly Ala Gln
545                 550                 555                 560 
Asp Ala Thr Glu Asn Ser Ala Ser Ser Leu Ala Pro Gly Phe Ile Arg
                565                 570                 575     
Gly Ala Gln Ala Ser Ser Gly Ser Pro Ala Leu Pro Arg Lys Gln Arg
            580                 585                 590         
Asp Lys Ser Pro Ser Ser Leu Leu Glu Asp Ala Lys Glu Thr Cys Phe
        595                 600                 605             
Thr Arg Asp Arg Lys Gly Gly Phe Phe Ser Ser Phe Met Lys Lys Arg
    610                 615                 620                 
Asn Ala Pro Thr Pro Pro Lys Arg Ser Ser Ser Phe Arg Glu Met Glu
625                 630                 635                 640 
Asn Gln Pro His Lys Lys Tyr Glu Leu Thr Gly Asn Phe Ser Ser Val
                645                 650                 655     
Ala Ser Leu Gln His Ala Asp Gly Phe Ser Phe Thr Pro Ala Gln Gln
            660                 665                 670         
Glu Ala Asn Leu Val Pro Pro Lys Cys Tyr Gly Gly Ser Phe Ala Gln
        675                 680                 685             
Arg Asn Leu Cys Asn Asp Asp Gly Gly Gly Gly Gly Gly Ser Gly Thr
    690                 695                 700                 
Ala Gly Gly Gly Trp Ser Gly Ile Thr Gly Phe Phe Thr Pro Arg Leu
705                 710                 715                 720 
Ile Lys Lys Thr Leu Gly Leu Arg Ala Gly Lys Pro Thr Ala Ser Asp
                725                 730                 735     
Asp Thr Ser Lys Pro Phe Pro Arg Ser Asn Ser Thr Ser Ser Met Ser
            740                 745                 750         
Ser Gly Leu Pro Glu Gln Asp Arg Met Ala Met Thr Leu Pro Arg Asn
        755                 760                 765             
Cys Gln Arg Ser Lys Leu Gln Leu Glu Arg Thr Val Ser Thr Ser Ser
    770                 775                 780                 
Gln Pro Glu Glu Asn Val Asp Arg Ala Asn Asp Met Leu Pro Lys Lys
785                 790                 795                 800 
Ser Glu Glu Ser Ala Ala Pro Ser Arg Glu Arg Pro Lys Ala Lys Leu
                805                 810                 815     
Leu Pro Arg Gly Ala Thr Ala Leu Pro Leu Arg Thr Pro Ser Gly Asp
            820                 825                 830         
Leu Ala Ile Thr Glu Lys Asp Pro Pro Gly Val Gly Val Ala Gly Val
        835                 840                 845             
Ala Ala Ala Pro Lys Gly Lys Glu Lys Asn Gly Gly Ala Arg Leu Gly
    850                 855                 860                 
Met Ala Gly Val Pro Glu Asp Gly Glu Gln Pro Gly Trp Pro Ser Pro
865                 870                 875                 880 
Ala Lys Ala Ala Pro Val Leu Pro Thr Thr His Asn His Lys Val Pro
                885                 890                 895     
Val Leu Ile Ser Pro Thr Leu Lys His Thr Pro Ala Asp Val Gln Leu
            900                 905                 910         
Ile Gly Thr Asp Ser Gln Gly Asn Lys Phe Lys Leu Leu Ser Glu His
        915                 920                 925             
Gln Val Thr Ser Ser Gly Asp Lys Asp Arg Pro Arg Arg Val Lys Pro
    930                 935                 940                 
Lys Cys Ala Pro Pro Pro Pro Pro Val Met Arg Leu Leu Gln His Pro
945                 950                 955                 960 
Ser Ile Cys Ser Asp Pro Thr Glu Glu Pro Thr Ala Leu Thr Ala Gly
                965                 970                 975     
Gln Ser Thr Ser Glu Thr Gln Glu Gly Gly Lys Lys Ala Ala Leu Gly
            980                 985                 990         
Ala Val Pro Ile Ser Gly Lys Ala Gly Arg Pro Val Met Pro Pro Pro
        995                 1000                1005            
Gln Val Pro Leu Pro Thr Ser Ser Ile Ser Pro Ala Lys Met Ala Asn
    1010                1015                1020                
Gly Thr Ala Gly Thr Lys Val Ala Leu Arg Lys Thr Lys Gln Ala Ala
1025                1030                1035               1040 
Glu Lys Ile Ser Ala Asp Lys Ile Ser Lys Glu Ala Leu Leu Glu Cys
                1045                1050                1055    
Ala Asp Leu Leu Ser Ser Ala Leu Thr Glu Pro Val Pro Asn Ser Gln
            1060                1065                1070        
Leu Val Asp Thr Gly His Gln Leu Leu Asp Tyr Cys Ser Gly Tyr Val
        1075                1080                1085            
Asp Cys Ile Pro Gln Thr Arg Asn Lys Phe Ala Phe Arg Glu Ala Val
    1090                1095                1100                
Ser Lys Leu Glu Leu Ser Leu Gln Glu Leu Gln Val Ser Ser Ala Ala
1105                1110                1115               1120 
Ala Gly Val Pro Gly Thr Asn Pro Val Leu Asn Asn Leu Leu Ser Cys
                1125                1130                1135    
Val Gln Glu Ile Ser Asp Val Val Gln Arg
            1140                1145    


<210> 74
<211> 335
<212> PRT
<213> Homo sapiens

<400> 74
Met Val Arg Pro Val Arg His Lys Lys Pro Val Asn Tyr Ser Gln Phe
 1               5                  10                  15      
Asp His Ser Asp Ser Asp Asp Asp Phe Val Ser Ala Thr Val Pro Leu
            20                  25                  30          
Asn Lys Lys Ser Arg Thr Ala Pro Lys Glu Leu Lys Gln Asp Lys Pro
        35                  40                  45              
Lys Pro Asn Leu Asn Asn Leu Arg Lys Glu Glu Ile Pro Val Gln Glu
    50                  55                  60                  
Lys Thr Pro Lys Lys Arg Met Ala Leu Asp Asp Lys Leu Tyr Gln Arg
65                  70                  75                  80  
Asp Leu Glu Val Ala Leu Ala Leu Ser Val Lys Glu Leu Pro Thr Val
                85                  90                  95      
Thr Thr Asn Val Gln Asn Ser Gln Asp Lys Ser Ile Glu Lys His Gly
            100                 105                 110         
Ser Ser Lys Ile Glu Thr Met Asn Lys Ser Pro His Ile Ser Asn Cys
        115                 120                 125             
Ser Val Ala Ser Asp Tyr Leu Asp Leu Asp Lys Ile Thr Val Glu Asp
    130                 135                 140                 
Asp Val Gly Gly Val Gln Gly Lys Arg Lys Ala Ala Ser Lys Ala Ala
145                 150                 155                 160 
Ala Gln Gln Arg Lys Ile Leu Leu Glu Gly Ser Asp Gly Asp Ser Ala
                165                 170                 175     
Asn Asp Thr Glu Pro Asp Phe Ala Pro Gly Glu Asp Ser Glu Asp Asp
            180                 185                 190         
Ser Asp Phe Cys Glu Ser Glu Asp Asn Asp Glu Asp Phe Ser Met Arg
        195                 200                 205             
Lys Ser Lys Val Lys Glu Ile Lys Lys Lys Glu Val Lys Val Lys Ser
    210                 215                 220                 
Pro Val Glu Lys Lys Glu Lys Lys Ser Lys Ser Lys Cys Asn Ala Leu
225                 230                 235                 240 
Val Thr Ser Val Asp Ser Ala Pro Ala Ala Val Lys Ser Glu Ser Gln
                245                 250                 255     
Ser Leu Pro Lys Lys Val Ser Leu Ser Ser Asp Thr Thr Arg Lys Pro
            260                 265                 270         
Leu Glu Ile Arg Ser Pro Ser Ala Glu Ser Lys Lys Pro Lys Trp Val
        275                 280                 285             
Pro Pro Ala Ala Ser Gly Gly Ser Arg Ser Ser Ser Ser Pro Leu Val
    290                 295                 300                 
Val Val Ser Val Lys Ser Pro Asn Gln Ser Leu Arg Leu Gly Leu Ser
305                 310                 315                 320 
Arg Leu Ala Arg Val Lys Pro Leu His Pro Asn Ala Thr Ser Thr
                325                 330                 335 


<210> 75
<211> 558
<212> PRT
<213> Homo sapiens

<400> 75
Met Ala Ile Pro Gly Arg Gln Tyr Gly Leu Ile Leu Pro Lys Lys Thr
 1               5                  10                  15      
Gln Gln Leu His Pro Val Leu Gln Lys Pro Ser Val Phe Gly Asn Asp
            20                  25                  30          
Ser Asp Asp Asp Asp Glu Thr Ser Val Ser Glu Ser Leu Gln Arg Glu
        35                  40                  45              
Ala Ala Lys Lys Gln Ala Met Lys Gln Thr Lys Leu Glu Ile Gln Lys
    50                  55                  60                  
Ala Leu Ala Glu Asp Ala Thr Val Tyr Glu Tyr Asp Ser Ile Tyr Asp
65                  70                  75                  80  
Glu Met Gln Lys Lys Lys Glu Glu Asn Asn Pro Lys Leu Leu Leu Gly
                85                  90                  95      
Lys Asp Arg Lys Pro Lys Tyr Ile His Asn Leu Leu Lys Ala Val Glu
            100                 105                 110         
Ile Arg Lys Lys Glu Gln Glu Lys Arg Met Glu Lys Lys Ile Gln Arg
        115                 120                 125             
Glu Arg Glu Met Glu Lys Gly Glu Phe Asp Asp Lys Glu Ala Phe Val
    130                 135                 140                 
Thr Ser Ala Tyr Lys Lys Lys Leu Gln Glu Arg Ala Glu Glu Glu Glu
145                 150                 155                 160 
Arg Glu Lys Arg Ala Ala Ala Leu Glu Ala Cys Leu Asp Val Thr Lys
                165                 170                 175     
Gln Lys Asp Leu Ser Gly Phe Tyr Arg His Leu Leu Asn Gln Ala Val
            180                 185                 190         
Gly Glu Glu Glu Val Pro Lys Cys Ser Phe Arg Glu Ala Arg Ser Gly
        195                 200                 205             
Ile Lys Glu Glu Lys Ser Arg Gly Phe Ser Asn Glu Val Ser Ser Lys
    210                 215                 220                 
Asn Arg Ile Pro Gln Glu Lys Cys Ile Leu Gln Thr Asp Val Lys Val
225                 230                 235                 240 
Glu Glu Asn Pro Asp Ala Asp Ser Asp Phe Asp Ala Lys Ser Ser Ala
                245                 250                 255     
Asp Asp Glu Ile Glu Glu Thr Arg Val Asn Cys Arg Arg Glu Lys Val
            260                 265                 270         
Ile Glu Thr Pro Glu Asn Asp Phe Lys His His Arg Ser Gln Asn His
        275                 280                 285             
Ser Arg Ser Pro Ser Glu Glu Arg Gly His Ser Thr Arg His His Thr
    290                 295                 300                 
Lys Gly Ser Arg Thr Ser Arg Gly His Glu Lys Arg Glu Asp Gln His
305                 310                 315                 320 
Gln Gln Lys Gln Ser Arg Asp Gln Glu Asn His Tyr Thr Asp Arg Asp
                325                 330                 335     
Tyr Arg Lys Glu Arg Asp Ser His Arg His Arg Glu Ala Ser His Arg
            340                 345                 350         
Asp Ser His Trp Lys Arg His Glu Gln Glu Asp Lys Pro Arg Ala Arg
        355                 360                 365             
Asp Gln Arg Glu Arg Ser Asp Arg Val Trp Lys Arg Glu Lys Asp Arg
    370                 375                 380                 
Glu Lys Tyr Ser Gln Arg Glu Gln Glu Arg Asp Arg Gln Gln Asn Asp
385                 390                 395                 400 
Gln Asn Arg Pro Ser Glu Lys Gly Glu Lys Glu Glu Lys Ser Lys Ala
                405                 410                 415     
Lys Glu Glu His Met Lys Val Arg Lys Glu Arg Tyr Glu Asn Asn Asp
            420                 425                 430         
Lys Tyr Arg Asp Arg Glu Lys Arg Glu Val Gly Val Gln Ser Ser Glu
        435                 440                 445             
Arg Asn Gln Asp Arg Lys Glu Ser Ser Pro Asn Ser Arg Ala Lys Asp
    450                 455                 460                 
Lys Phe Leu Asp Gln Glu Arg Ser Asn Lys Met Arg Asn Met Ala Lys
465                 470                 475                 480 
Asp Lys Glu Arg Asn Gln Glu Lys Pro Ser Asn Ser Glu Ser Ser Leu
                485                 490                 495     
Gly Ala Lys His Arg Leu Thr Glu Glu Gly Gln Glu Lys Gly Lys Glu
            500                 505                 510         
Gln Glu Arg Pro Pro Glu Ala Val Ser Lys Phe Ala Lys Arg Asn Asn
        515                 520                 525             
Glu Glu Thr Val Met Ser Ala Arg Asp Arg Tyr Leu Ala Arg Gln Met
    530                 535                 540                 
Ala Arg Val Asn Ala Lys Thr Tyr Ile Glu Lys Glu Asp Asp
545                 550                 555             


<210> 76
<211> 1242
<212> PRT
<213> Homo sapiens

<400> 76
Met Ala Ser Pro Pro Glu Ser Asp Gly Phe Ser Asp Val Arg Lys Val
 1               5                  10                  15      
Gly Tyr Leu Arg Lys Pro Lys Ser Met His Lys Arg Phe Phe Val Leu
            20                  25                  30          
Arg Ala Ala Ser Glu Ala Gly Gly Pro Ala Arg Leu Glu Tyr Tyr Glu
        35                  40                  45              
Asn Glu Lys Lys Trp Arg His Lys Ser Ser Ala Pro Lys Arg Ser Ile
    50                  55                  60                  
Pro Leu Glu Ser Cys Phe Asn Ile Asn Lys Arg Ala Asp Ser Lys Asn
65                  70                  75                  80  
Lys His Leu Val Ala Leu Tyr Thr Arg Asp Glu His Phe Ala Ile Ala
                85                  90                  95      
Ala Asp Ser Glu Ala Glu Gln Asp Ser Trp Tyr Gln Ala Leu Leu Gln
            100                 105                 110         
Leu His Asn Arg Ala Lys Gly His His Asp Gly Ala Ala Ala Leu Gly
        115                 120                 125             
Ala Gly Gly Gly Gly Gly Ser Cys Ser Gly Ser Ser Gly Leu Gly Glu
    130                 135                 140                 
Ala Gly Glu Asp Leu Ser Tyr Gly Asp Val Pro Pro Gly Pro Ala Phe
145                 150                 155                 160 
Lys Glu Val Trp Gln Val Ile Leu Lys Pro Lys Gly Leu Gly Gln Thr
                165                 170                 175     
Lys Asn Leu Ile Gly Ile Tyr Arg Leu Cys Leu Thr Ser Lys Thr Ile
            180                 185                 190         
Ser Phe Val Lys Leu Asn Ser Glu Ala Ala Ala Val Val Leu Gln Leu
        195                 200                 205             
Met Asn Ile Arg Arg Cys Gly His Ser Glu Asn Phe Phe Phe Ile Glu
    210                 215                 220                 
Val Gly Arg Ser Ala Val Thr Gly Pro Gly Glu Phe Trp Met Gln Val
225                 230                 235                 240 
Asp Asp Ser Val Val Ala Gln Asn Met His Glu Thr Ile Leu Glu Ala
                245                 250                 255     
Met Arg Ala Met Ser Asp Glu Phe Arg Pro Arg Ser Lys Ser Gln Ser
            260                 265                 270         
Ser Ser Asn Cys Ser Asn Pro Ile Ser Val Pro Leu Arg Arg His His
        275                 280                 285             
Leu Asn Asn Pro Pro Pro Ser Gln Val Gly Leu Thr Arg Arg Ser Arg
    290                 295                 300                 
Thr Glu Ser Ile Thr Ala Thr Ser Pro Ala Ser Met Val Gly Gly Lys
305                 310                 315                 320 
Pro Gly Ser Phe Arg Val Arg Ala Ser Ser Asp Gly Glu Gly Thr Met
                325                 330                 335     
Ser Arg Pro Ala Ser Val Asp Gly Ser Pro Val Ser Pro Ser Thr Asn
            340                 345                 350         
Arg Thr His Ala His Arg His Arg Gly Ser Ala Arg Leu His Pro Pro
        355                 360                 365             
Leu Asn His Ser Arg Ser Ile Pro Met Pro Ala Ser Arg Cys Ser Pro
    370                 375                 380                 
Ser Ala Thr Ser Pro Val Ser Leu Ser Ser Ser Ser Thr Ser Gly His
385                 390                 395                 400 
Gly Ser Thr Ser Asp Cys Leu Phe Pro Arg Arg Ser Ser Ala Ser Val
                405                 410                 415     
Ser Gly Ser Pro Ser Asp Gly Gly Phe Ile Ser Ser Asp Glu Tyr Gly
            420                 425                 430         
Ser Ser Pro Cys Asp Phe Arg Ser Ser Phe Arg Ser Val Thr Pro Asp
        435                 440                 445             
Ser Leu Gly His Thr Pro Pro Ala Arg Gly Glu Glu Glu Leu Ser Asn
    450                 455                 460                 
Tyr Ile Cys Met Gly Gly Lys Gly Pro Ser Thr Leu Thr Ala Pro Asn
465                 470                 475                 480 
Gly His Tyr Ile Leu Ser Arg Gly Gly Asn Gly His Arg Cys Thr Pro
                485                 490                 495     
Gly Thr Gly Leu Gly Thr Ser Pro Ala Leu Ala Gly Asp Glu Ala Ala
            500                 505                 510         
Ser Ala Ala Asp Leu Asp Asn Arg Phe Arg Lys Arg Thr His Ser Ala
        515                 520                 525             
Gly Thr Ser Pro Thr Ile Thr His Gln Lys Thr Pro Ser Gln Ser Ser
    530                 535                 540                 
Val Ala Ser Ile Glu Glu Tyr Thr Glu Met Met Pro Ala Tyr Pro Pro
545                 550                 555                 560 
Gly Gly Gly Ser Gly Gly Arg Leu Pro Gly His Arg His Ser Ala Phe
                565                 570                 575     
Val Pro Thr Arg Ser Tyr Pro Glu Glu Gly Leu Glu Met His Pro Leu
            580                 585                 590         
Glu Arg Arg Gly Gly His His Arg Pro Asp Ser Ser Thr Leu His Thr
        595                 600                 605             
Asp Asp Gly Tyr Met Pro Met Ser Pro Gly Val Ala Pro Val Pro Ser
    610                 615                 620                 
Gly Arg Lys Gly Ser Gly Asp Tyr Met Pro Met Ser Pro Lys Ser Val
625                 630                 635                 640 
Ser Ala Pro Gln Gln Ile Ile Asn Pro Ile Arg Arg His Pro Gln Arg
                645                 650                 655     
Val Asp Pro Asn Gly Tyr Met Met Met Ser Pro Ser Gly Gly Cys Ser
            660                 665                 670         
Pro Asp Ile Gly Gly Gly Pro Ser Ser Ser Ser Ser Ser Ser Asn Ala
        675                 680                 685             
Val Pro Ser Gly Thr Ser Tyr Gly Lys Leu Trp Thr Asn Gly Val Gly
    690                 695                 700                 
Gly His His Ser His Val Leu Pro His Pro Lys Pro Pro Val Glu Ser
705                 710                 715                 720 
Ser Gly Gly Lys Leu Leu Pro Cys Thr Gly Asp Tyr Met Asn Met Ser
                725                 730                 735     
Pro Val Gly Asp Ser Asn Thr Ser Ser Pro Ser Asp Cys Tyr Tyr Gly
            740                 745                 750         
Pro Glu Asp Pro Gln His Lys Pro Val Leu Ser Tyr Tyr Ser Leu Pro
        755                 760                 765             
Arg Ser Phe Lys His Thr Gln Arg Pro Gly Glu Pro Glu Glu Gly Ala
    770                 775                 780                 
Arg His Gln His Leu Arg Leu Ser Thr Ser Ser Gly Arg Leu Leu Tyr
785                 790                 795                 800 
Ala Ala Thr Ala Asp Asp Ser Ser Ser Ser Thr Ser Ser Asp Ser Leu
                805                 810                 815     
Gly Gly Gly Tyr Cys Gly Ala Arg Leu Glu Pro Ser Leu Pro His Pro
            820                 825                 830         
His His Gln Val Leu Gln Pro His Leu Pro Arg Lys Val Asp Thr Ala
        835                 840                 845             
Ala Gln Thr Asn Ser Arg Leu Ala Arg Pro Thr Arg Leu Ser Leu Gly
    850                 855                 860                 
Asp Pro Lys Ala Ser Thr Leu Pro Arg Ala Arg Glu Gln Gln Gln Gln
865                 870                 875                 880 
Gln Gln Pro Leu Leu His Pro Pro Glu Pro Lys Ser Pro Gly Glu Tyr
                885                 890                 895     
Val Asn Ile Glu Phe Gly Ser Asp Gln Ser Gly Tyr Leu Ser Gly Pro
            900                 905                 910         
Val Ala Phe His Ser Ser Pro Ser Val Arg Cys Pro Ser Gln Leu Gln
        915                 920                 925             
Pro Ala Pro Arg Glu Glu Glu Thr Gly Thr Glu Glu Tyr Met Lys Met
    930                 935                 940                 
Asp Leu Gly Pro Gly Arg Arg Ala Ala Trp Gln Glu Ser Thr Gly Val
945                 950                 955                 960 
Glu Met Gly Arg Leu Gly Pro Ala Pro Pro Gly Ala Ala Ser Ile Cys
                965                 970                 975     
Arg Pro Thr Arg Ala Val Pro Ser Ser Arg Gly Asp Tyr Met Thr Met
            980                 985                 990         
Gln Met Ser Cys Pro Arg Gln Ser Tyr Val Asp Thr Ser Pro Ala Ala
        995                 1000                1005            
Pro Val Ser Tyr Ala Asp Met Arg Thr Gly Ile Ala Ala Glu Glu Val
    1010                1015                1020                
Ser Leu Pro Arg Ala Thr Met Ala Ala Ala Ser Ser Ser Ser Ala Ala
1025                1030                1035               1040 
Ser Ala Ser Pro Thr Gly Pro Gln Gly Ala Ala Glu Leu Ala Ala His
                1045                1050                1055    
Ser Ser Leu Leu Gly Gly Pro Gln Gly Pro Gly Gly Met Ser Ala Phe
            1060                1065                1070        
Thr Arg Val Asn Leu Ser Pro Asn Arg Asn Gln Ser Ala Lys Val Ile
        1075                1080                1085            
Arg Ala Asp Pro Gln Gly Cys Arg Arg Arg His Ser Ser Glu Thr Phe
    1090                1095                1100                
Ser Ser Thr Pro Ser Ala Thr Arg Val Gly Asn Thr Val Pro Phe Gly
1105                1110                1115               1120 
Ala Gly Ala Ala Val Gly Gly Gly Gly Gly Ser Ser Ser Ser Ser Glu
                1125                1130                1135    
Asp Val Lys Arg His Ser Ser Ala Ser Phe Glu Asn Val Trp Leu Arg
            1140                1145                1150        
Pro Gly Glu Leu Gly Gly Ala Pro Lys Glu Pro Ala Lys Leu Cys Gly
        1155                1160                1165            
Ala Ala Gly Gly Leu Glu Asn Gly Leu Asn Tyr Ile Asp Leu Asp Leu
    1170                1175                1180                
Val Lys Asp Phe Lys Gln Cys Pro Gln Glu Cys Thr Pro Glu Pro Gln
1185                1190                1195               1200 
Pro Pro Pro Pro Pro Pro Pro His Gln Pro Leu Gly Ser Gly Glu Ser
                1205                1210                1215    
Ser Ser Thr Arg Arg Ser Ser Glu Asp Leu Ser Ala Tyr Ala Ser Ile
            1220                1225                1230        
Ser Phe Gln Lys Gln Pro Glu Asp Arg Gln
        1235                1240        


<210> 77
<211> 1106
<212> PRT
<213> Homo sapiens

<400> 77
Met Arg Leu Pro Gly Ala Met Pro Ala Leu Ala Leu Lys Gly Glu Leu
 1               5                  10                  15      
Leu Leu Leu Ser Leu Leu Leu Leu Leu Glu Pro Gln Ile Ser Gln Gly
            20                  25                  30          
Leu Val Val Thr Pro Pro Gly Pro Glu Leu Val Leu Asn Val Ser Ser
        35                  40                  45              
Thr Phe Val Leu Thr Cys Ser Gly Ser Ala Pro Val Val Trp Glu Arg
    50                  55                  60                  
Met Ser Gln Glu Pro Pro Gln Glu Met Ala Lys Ala Gln Asp Gly Thr
65                  70                  75                  80  
Phe Ser Ser Val Leu Thr Leu Thr Asn Leu Thr Gly Leu Asp Thr Gly
                85                  90                  95      
Glu Tyr Phe Cys Thr His Asn Asp Ser Arg Gly Leu Glu Thr Asp Glu
            100                 105                 110         
Arg Lys Arg Leu Tyr Ile Phe Val Pro Asp Pro Thr Val Gly Phe Leu
        115                 120                 125             
Pro Asn Asp Ala Glu Glu Leu Phe Ile Phe Leu Thr Glu Ile Thr Glu
    130                 135                 140                 
Ile Thr Ile Pro Cys Arg Val Thr Asp Pro Gln Leu Val Val Thr Leu
145                 150                 155                 160 
His Glu Lys Lys Gly Asp Val Ala Leu Pro Val Pro Tyr Asp His Gln
                165                 170                 175     
Arg Gly Phe Ser Gly Ile Phe Glu Asp Arg Ser Tyr Ile Cys Lys Thr
            180                 185                 190         
Thr Ile Gly Asp Arg Glu Val Asp Ser Asp Ala Tyr Tyr Val Tyr Arg
        195                 200                 205             
Leu Gln Val Ser Ser Ile Asn Val Ser Val Asn Ala Val Gln Thr Val
    210                 215                 220                 
Val Arg Gln Gly Glu Asn Ile Thr Leu Met Cys Ile Val Ile Gly Asn
225                 230                 235                 240 
Glu Val Val Asn Phe Glu Trp Thr Tyr Pro Arg Lys Glu Ser Gly Arg
                245                 250                 255     
Leu Val Glu Pro Val Thr Asp Phe Leu Leu Asp Met Pro Tyr His Ile
            260                 265                 270         
Arg Ser Ile Leu His Ile Pro Ser Ala Glu Leu Glu Asp Ser Gly Thr
        275                 280                 285             
Tyr Thr Cys Asn Val Thr Glu Ser Val Asn Asp His Gln Asp Glu Lys
    290                 295                 300                 
Ala Ile Asn Ile Thr Val Val Glu Ser Gly Tyr Val Arg Leu Leu Gly
305                 310                 315                 320 
Glu Val Gly Thr Leu Gln Phe Ala Glu Leu His Arg Ser Arg Thr Leu
                325                 330                 335     
Gln Val Val Phe Glu Ala Tyr Pro Pro Pro Thr Val Leu Trp Phe Lys
            340                 345                 350         
Asp Asn Arg Thr Leu Gly Asp Ser Ser Ala Gly Glu Ile Ala Leu Ser
        355                 360                 365             
Thr Arg Asn Val Ser Glu Thr Arg Tyr Val Ser Glu Leu Thr Leu Val
    370                 375                 380                 
Arg Val Lys Val Ala Glu Ala Gly His Tyr Thr Met Arg Ala Phe His
385                 390                 395                 400 
Glu Asp Ala Glu Val Gln Leu Ser Phe Gln Leu Gln Ile Asn Val Pro
                405                 410                 415     
Val Arg Val Leu Glu Leu Ser Glu Ser His Pro Asp Ser Gly Glu Gln
            420                 425                 430         
Thr Val Arg Cys Arg Gly Arg Gly Met Pro Gln Pro Asn Ile Ile Trp
        435                 440                 445             
Ser Ala Cys Arg Asp Leu Lys Arg Cys Pro Arg Glu Leu Pro Pro Thr
    450                 455                 460                 
Leu Leu Gly Asn Ser Ser Glu Glu Glu Ser Gln Leu Glu Thr Asn Val
465                 470                 475                 480 
Thr Tyr Trp Glu Glu Glu Gln Glu Phe Glu Val Val Ser Thr Leu Arg
                485                 490                 495     
Leu Gln His Val Asp Arg Pro Leu Ser Val Arg Cys Thr Leu Arg Asn
            500                 505                 510         
Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu
        515                 520                 525             
Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu
    530                 535                 540                 
Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys Pro
545                 550                 555                 560 
Arg Tyr Glu Ile Arg Trp Lys Val Ile Glu Ser Val Ser Ser Asp Gly
                565                 570                 575     
His Glu Tyr Ile Tyr Val Asp Pro Met Gln Leu Pro Tyr Asp Ser Thr
            580                 585                 590         
Trp Glu Leu Pro Arg Asp Gln Leu Val Leu Gly Arg Thr Leu Gly Ser
        595                 600                 605             
Gly Ala Phe Gly Gln Val Val Glu Ala Thr Ala His Gly Leu Ser His
    610                 615                 620                 
Ser Gln Ala Thr Met Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala
625                 630                 635                 640 
Arg Ser Ser Glu Lys Gln Ala Leu Met Ser Glu Leu Lys Ile Met Ser
                645                 650                 655     
His Leu Gly Pro His Leu Asn Val Val Asn Leu Leu Gly Ala Cys Thr
            660                 665                 670         
Lys Gly Gly Pro Ile Tyr Ile Ile Thr Glu Tyr Cys Arg Tyr Gly Asp
        675                 680                 685             
Leu Val Asp Tyr Leu His Arg Asn Lys His Thr Phe Leu Gln His His
    690                 695                 700                 
Ser Asp Lys Arg Arg Pro Pro Ser Ala Glu Leu Tyr Ser Asn Ala Leu
705                 710                 715                 720 
Pro Val Gly Leu Pro Leu Pro Ser His Val Ser Leu Thr Gly Glu Ser
                725                 730                 735     
Asp Gly Gly Tyr Met Asp Met Ser Lys Asp Glu Ser Val Asp Tyr Val
            740                 745                 750         
Pro Met Leu Asp Met Lys Gly Asp Val Lys Tyr Ala Asp Ile Glu Ser
        755                 760                 765             
Ser Asn Tyr Met Ala Pro Tyr Asp Asn Tyr Val Pro Ser Ala Pro Glu
    770                 775                 780                 
Arg Thr Cys Arg Ala Thr Leu Ile Asn Glu Ser Pro Val Leu Ser Tyr
785                 790                 795                 800 
Met Asp Leu Val Gly Phe Ser Tyr Gln Val Ala Asn Gly Met Glu Phe
                805                 810                 815     
Leu Ala Ser Lys Asn Cys Val His Arg Asp Leu Ala Ala Arg Asn Val
            820                 825                 830         
Leu Ile Cys Glu Gly Lys Leu Val Lys Ile Cys Asp Phe Gly Leu Ala
        835                 840                 845             
Arg Asp Ile Met Arg Asp Ser Asn Tyr Ile Ser Lys Gly Ser Thr Phe
    850                 855                 860                 
Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Ser Leu Tyr
865                 870                 875                 880 
Thr Thr Leu Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile
                885                 890                 895     
Phe Thr Leu Gly Gly Thr Pro Tyr Pro Glu Leu Pro Met Asn Glu Gln
            900                 905                 910         
Phe Tyr Asn Ala Ile Lys Arg Gly Tyr Arg Met Ala Gln Pro Ala His
        915                 920                 925             
Ala Ser Asp Glu Ile Tyr Glu Ile Met Gln Lys Cys Trp Glu Glu Lys
    930                 935                 940                 
Phe Glu Ile Arg Pro Pro Phe Ser Gln Leu Val Leu Leu Leu Glu Arg
945                 950                 955                 960 
Leu Leu Gly Glu Gly Tyr Lys Lys Lys Tyr Gln Gln Val Asp Glu Glu
                965                 970                 975     
Phe Leu Arg Ser Asp His Pro Ala Ile Leu Arg Ser Gln Ala Arg Leu
            980                 985                 990         
Pro Gly Phe His Gly Leu Arg Ser Pro Leu Asp Thr Ser Ser Val Leu
        995                 1000                1005            
Tyr Thr Ala Val Gln Pro Asn Glu Gly Asp Asn Asp Tyr Ile Ile Pro
    1010                1015                1020                
Leu Pro Asp Pro Lys Pro Glu Val Ala Asp Glu Gly Pro Leu Glu Gly
1025                1030                1035               1040 
Ser Pro Ser Leu Ala Ser Ser Thr Leu Asn Glu Val Asn Thr Ser Ser
                1045                1050                1055    
Thr Ile Ser Cys Asp Ser Pro Leu Glu Pro Gln Asp Glu Pro Glu Pro
            1060                1065                1070        
Glu Pro Gln Leu Glu Leu Gln Val Glu Pro Glu Pro Glu Leu Glu Gln
        1075                1080                1085            
Leu Pro Asp Ser Gly Cys Pro Ala Pro Arg Ala Glu Ala Glu Asp Ser
    1090                1095                1100                
Phe Leu
1105    


<210> 78
<211> 486
<212> PRT
<213> Homo sapiens

<400> 78
Met Ala Trp Ile Lys Arg Lys Phe Gly Glu Arg Pro Pro Pro Lys Arg
 1               5                  10                  15      
Leu Thr Arg Glu Ala Met Arg Asn Tyr Leu Lys Glu Arg Gly Asp Gln
            20                  25                  30          
Thr Val Leu Ile Leu His Ala Lys Val Ala Gln Lys Ser Tyr Gly Asn
        35                  40                  45              
Glu Lys Arg Phe Phe Cys Pro Pro Pro Cys Val Tyr Leu Met Gly Ser
    50                  55                  60                  
Gly Trp Lys Lys Lys Lys Glu Gln Met Glu Arg Asp Gly Cys Ser Glu
65                  70                  75                  80  
Gln Glu Ser Gln Pro Cys Ala Phe Ile Gly Ile Gly Asn Ser Asp Gln
                85                  90                  95      
Glu Met Gln Gln Leu Asn Leu Glu Gly Lys Asn Tyr Cys Thr Ala Lys
            100                 105                 110         
Thr Leu Tyr Ile Ser Asp Ser Asp Lys Arg Lys His Phe Met Leu Ser
        115                 120                 125             
Val Lys Met Phe Tyr Gly Asn Ser Asp Asp Ile Gly Val Phe Leu Ser
    130                 135                 140                 
Lys Arg Ile Lys Val Ile Ser Lys Pro Ser Lys Lys Lys Gln Ser Leu
145                 150                 155                 160 
Lys Asn Ala Asp Leu Cys Ile Ala Ser Gly Thr Lys Val Ala Leu Phe
                165                 170                 175     
Asn Arg Leu Arg Ser Gln Thr Val Ser Thr Arg Tyr Leu His Val Glu
            180                 185                 190         
Gly Gly Asn Phe His Ala Ser Ser Gln Gln Trp Gly Ala Phe Phe Ile
        195                 200                 205             
His Leu Leu Asp Asp Asp Glu Ser Glu Gly Glu Glu Phe Thr Val Arg
    210                 215                 220                 
Asp Gly Tyr Ile His Tyr Gly Gln Thr Val Lys Leu Val Cys Ser Val
225                 230                 235                 240 
Thr Gly Met Ala Leu Pro Arg Leu Ile Ile Arg Lys Val Asp Lys Gln
                245                 250                 255     
Thr Ala Leu Leu Asp Ala Asp Asp Pro Val Ser Gln Leu His Lys Cys
            260                 265                 270         
Ala Phe Tyr Leu Lys Asp Thr Glu Arg Met Tyr Leu Cys Leu Ser Gln
        275                 280                 285             
Glu Arg Ile Ile Gln Phe Gln Ala Thr Pro Cys Pro Lys Glu Pro Asn
    290                 295                 300                 
Lys Glu Met Ile Asn Asp Gly Ala Ser Trp Thr Ile Ile Ser Thr Asp
305                 310                 315                 320 
Lys Ala Glu Tyr Thr Phe Tyr Glu Gly Met Gly Pro Val Leu Ala Pro
                325                 330                 335     
Val Thr Pro Val Pro Val Val Glu Ser Leu Gln Leu Asn Gly Gly Gly
            340                 345                 350         
Asp Val Ala Met Leu Glu Leu Thr Gly Gln Asn Phe Thr Pro Asn Leu
        355                 360                 365             
Arg Val Trp Phe Gly Asp Val Glu Ala Glu Thr Met Tyr Arg Cys Gly
    370                 375                 380                 
Glu Ser Met Leu Cys Val Val Pro Asp Ile Ser Ala Phe Arg Glu Gly
385                 390                 395                 400 
Trp Arg Trp Val Arg Gln Pro Val Gln Val Pro Val Thr Leu Val Arg
                405                 410                 415     
Asn Asp Gly Ile Ile Tyr Ser Thr Ser Leu Thr Phe Thr Tyr Thr Pro
            420                 425                 430         
Glu Pro Gly Pro Arg Pro His Cys Ser Ala Ala Gly Ala Ile Leu Arg
        435                 440                 445             
Ala Asn Ser Ser Gln Val Pro Pro Asn Glu Ser Asn Thr Asn Ser Glu
    450                 455                 460                 
Gly Ser Tyr Thr Asn Ala Ser Thr Asn Ser Thr Ser Val Thr Ser Ser
465                 470                 475                 480 
Thr Ala Thr Val Val Ser
                485     


<210> 79
<211> 402
<212> PRT
<213> Homo sapiens

<400> 79
Met Ile Pro Pro Ser Ser Pro Arg Glu Asp Gly Val Asp Gly Leu Pro
 1               5                  10                  15      
Lys Glu Ala Val Gly Ala Glu Gln Pro Pro Ser Pro Ala Ser Thr Ser
            20                  25                  30          
Ser Gln Glu Ser Lys Leu Gln Lys Leu Lys Arg Ser Leu Ser Phe Lys
        35                  40                  45              
Thr Lys Ser Leu Arg Ser Lys Ser Ala Asp Asn Phe Phe Gln Arg Thr
    50                  55                  60                  
Asn Ser Glu Asp Met Lys Leu Gln Ala His Met Val Ala Glu Ile Ser
65                  70                  75                  80  
Pro Ser Ser Ser Pro Leu Pro Ala Pro Gly Ser Leu Thr Ser Thr Pro
                85                  90                  95      
Ala Arg Ala Gly Leu His Pro Gly Gly Lys Ala His Ala Phe His Glu
            100                 105                 110         
Tyr Ile Phe Lys Lys Pro Thr Phe Cys Asp Val Cys Asn His Met Ile
        115                 120                 125             
Val Gly Thr Asn Ala Lys His Gly Leu Arg Cys Lys Ala Cys Lys Met
    130                 135                 140                 
Ser Ile His His Lys Cys Thr Asp Gly Leu Ala Pro Gln Arg Cys Met
145                 150                 155                 160 
Gly Lys Leu Pro Lys Gly Phe Arg Arg Tyr Tyr Ser Ser Pro Leu Leu
                165                 170                 175     
Ile His Glu Gln Phe Gly Cys Ile Lys Glu Val Met Pro Ile Ala Cys
            180                 185                 190         
Gly Asn Lys Val Asp Pro Val Tyr Glu Thr Leu Arg Phe Gly Thr Ser
        195                 200                 205             
Leu Ala Gln Arg Thr Lys Lys Gly Ser Ser Gly Ser Gly Ser Asp Ser
    210                 215                 220                 
Pro His Arg Thr Ser Thr Ser Asp Leu Val Glu Val Pro Glu Glu Ala
225                 230                 235                 240 
Asn Gly Pro Gly Gly Gly Tyr Asp Leu Arg Lys Arg Ser Asn Ser Val
                245                 250                 255     
Phe Thr Tyr Pro Glu Asn Gly Thr Asp Asp Phe Arg Asp Pro Ala Lys
            260                 265                 270         
Asn Ile Asn His Gln Gly Ser Leu Ser Lys Asp Pro Leu Gln Met Asn
        275                 280                 285             
Thr Tyr Val Ala Leu Tyr Lys Phe Val Pro Gln Glu Asn Glu Asp Leu
    290                 295                 300                 
Glu Met Arg Pro Gly Asp Ile Ile Thr Leu Leu Glu Asp Ser Asn Glu
305                 310                 315                 320 
Asp Trp Trp Lys Gly Lys Ile Gln Asp Arg Ile Gly Phe Phe Pro Ala
                325                 330                 335     
Asn Phe Val Gln Arg Leu Gln Gln Asn Glu Lys Ile Phe Arg Cys Val
            340                 345                 350         
Arg Thr Phe Ile Gly Cys Lys Glu Gln Gly Gln Ile Thr Leu Lys Glu
        355                 360                 365             
Asn Gln Ile Cys Val Ser Ser Glu Glu Glu Gln Asp Gly Phe Ile Arg
    370                 375                 380                 
Val Leu Ser Gly Lys Lys Lys Gly Leu Ile Pro Leu Asp Val Leu Glu
385                 390                 395                 400 
Asn Ile
        


<210> 80
<211> 293
<212> PRT
<213> Homo sapiens

<400> 80
Met Pro Ala Arg Ser Gly Ala Gln Phe Cys Arg Arg Met Gly Gln Lys
 1               5                  10                  15      
Lys Gln Arg Pro Ala Arg Ala Gly Gln Pro His Ser Ser Ser Asp Ala
            20                  25                  30          
Ala Gln Ala Pro Ala Glu Gln Pro His Ser Ser Ser Asp Ala Ala Gln
        35                  40                  45              
Ala Pro Cys Pro Arg Glu Arg Cys Leu Gly Pro Pro Thr Thr Pro Gly
    50                  55                  60                  
Pro Tyr Arg Ser Ile Tyr Phe Ser Ser Pro Lys Gly His Leu Thr Arg
65                  70                  75                  80  
Leu Gly Leu Glu Phe Phe Asp Gln Pro Ala Val Pro Leu Ala Arg Ala
                85                  90                  95      
Phe Leu Gly Gln Val Leu Val Arg Arg Leu Pro Asn Gly Thr Glu Leu
            100                 105                 110         
Arg Gly Arg Ile Val Glu Thr Glu Ala Tyr Leu Gly Pro Glu Asp Glu
        115                 120                 125             
Ala Ala His Ser Arg Gly Gly Arg Gln Thr Pro Arg Asn Arg Gly Met
    130                 135                 140                 
Phe Met Lys Pro Gly Thr Leu Tyr Val Tyr Ile Ile Tyr Gly Met Tyr
145                 150                 155                 160 
Phe Cys Met Asn Ile Ser Ser Gln Gly Asp Gly Ala Cys Val Leu Leu
                165                 170                 175     
Arg Ala Leu Glu Pro Leu Glu Gly Leu Glu Thr Met Arg Gln Leu Arg
            180                 185                 190         
Ser Thr Leu Arg Lys Gly Thr Ala Ser Arg Val Leu Lys Asp Arg Glu
        195                 200                 205             
Leu Cys Ser Gly Pro Ser Lys Leu Cys Gln Ala Leu Ala Ile Asn Lys
    210                 215                 220                 
Ser Phe Asp Gln Arg Asp Leu Ala Gln Asp Glu Ala Val Trp Leu Glu
225                 230                 235                 240 
Arg Gly Pro Leu Glu Pro Ser Glu Pro Ala Val Val Ala Ala Ala Arg
                245                 250                 255     
Val Gly Val Gly His Ala Gly Glu Trp Ala Arg Lys Pro Leu Arg Phe
            260                 265                 270         
Tyr Val Arg Gly Ser Pro Trp Val Ser Val Val Asp Arg Val Ala Glu
        275                 280                 285             
Gln Asp Thr Gln Ala
    290             


<210> 81
<211> 424
<212> PRT
<213> Homo sapiens

<400> 81
Met Ala Ala Gly Pro Ile Ser Glu Arg Asn Gln Asp Ala Thr Val Tyr
 1               5                  10                  15      
Val Gly Gly Leu Asp Glu Lys Val Ser Glu Pro Leu Leu Trp Glu Leu
            20                  25                  30          
Phe Leu Gln Ala Gly Pro Val Val Asn Thr His Met Pro Lys Asp Arg
        35                  40                  45              
Val Thr Gly Gln His Gln Gly Tyr Gly Phe Val Glu Phe Leu Ser Glu
    50                  55                  60                  
Glu Asp Ala Asp Tyr Ala Ile Lys Ile Met Asn Met Ile Lys Leu Tyr
65                  70                  75                  80  
Gly Lys Pro Ile Arg Val Asn Lys Ala Ser Ala His Asn Lys Asn Leu
                85                  90                  95      
Asp Val Gly Ala Asn Ile Phe Ile Gly Asn Leu Asp Pro Glu Ile Asp
            100                 105                 110         
Glu Lys Leu Leu Tyr Asp Thr Phe Ser Ala Phe Gly Val Ile Leu Gln
        115                 120                 125             
Thr Pro Lys Ile Met Arg Asp Pro Asp Thr Gly Asn Ser Lys Gly Tyr
    130                 135                 140                 
Ala Phe Ile Asn Phe Ala Ser Phe Asp Ala Ser Asp Ala Ala Ile Glu
145                 150                 155                 160 
Ala Met Asn Gly Gln Tyr Leu Cys Asn Arg Pro Ile Thr Val Ser Tyr
                165                 170                 175     
Ala Phe Lys Lys Asp Ser Lys Gly Glu Arg His Gly Ser Ala Ala Glu
            180                 185                 190         
Arg Leu Leu Ala Ala Gln Asn Pro Leu Ser Gln Ala Asp Arg Pro His
        195                 200                 205             
Gln Leu Phe Ala Asp Ala Pro Pro Pro Pro Ser Ala Pro Asn Pro Val
    210                 215                 220                 
Val Ser Ser Leu Gly Ser Gly Leu Pro Pro Pro Gly Met Pro Pro Pro
225                 230                 235                 240 
Gly Ser Phe Pro Pro Pro Val Pro Pro Pro Gly Ala Leu Pro Pro Gly
                245                 250                 255     
Ile Pro Pro Ala Met Pro Pro Pro Pro Met Pro Pro Gly Ala Ala Gly
            260                 265                 270         
His Gly Pro Pro Ser Ala Gly Thr Pro Gly Ala Gly His Pro Gly His
        275                 280                 285             
Gly His Ser His Pro His Pro Phe Pro Pro Gly Gly Met Pro His Pro
    290                 295                 300                 
Gly Met Ser Gln Met Gln Leu Ala His His Gly Pro His Gly Leu Gly
305                 310                 315                 320 
His Pro His Ala Gly Pro Pro Gly Ser Gly Gly Gln Pro Pro Pro Arg
                325                 330                 335     
Pro Pro Pro Gly Met Pro His Pro Gly Pro Pro Pro Met Gly Met Pro
            340                 345                 350         
Pro Arg Gly Pro Pro Phe Gly Ser Pro Met Gly His Pro Gly Pro Met
        355                 360                 365             
Pro Pro His Gly Met Arg Gly Pro Pro Pro Leu Met Pro Pro His Gly
    370                 375                 380                 
Tyr Thr Gly Pro Pro Arg Pro Pro Pro Tyr Gly Tyr Gln Arg Gly Pro
385                 390                 395                 400 
Leu Pro Pro Pro Arg Pro Thr Pro Arg Pro Pro Val Pro Pro Arg Gly
                405                 410                 415     
Pro Leu Arg Gly Pro Leu Pro Gln
            420                 


<210> 82
<211> 806
<212> PRT
<213> Homo sapiens

<400> 82
Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile
 1               5                  10                  15      
Val Ala Gly Ala Ser Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val
            20                  25                  30          
Gly Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln
        35                  40                  45              
Leu Val Phe Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro
    50                  55                  60                  
Gly Gly Gly Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly
65                  70                  75                  80  
Leu Val Pro Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val
                85                  90                  95      
Leu Asn Ala Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg
            100                 105                 110         
Leu Thr Gln Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala
        115                 120                 125             
Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr
    130                 135                 140                 
Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp
145                 150                 155                 160 
Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys
                165                 170                 175     
Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly
            180                 185                 190         
Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His
        195                 200                 205             
Gln Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly
    210                 215                 220                 
Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr
225                 230                 235                 240 
Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln
                245                 250                 255     
Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu
            260                 265                 270         
Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu
        275                 280                 285             
Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro
    290                 295                 300                 
Tyr Val Thr Val Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu
305                 310                 315                 320 
Leu Glu Val Leu Ser Leu His Asn Val Thr Phe Glu Asp Ala Gly Glu
                325                 330                 335     
Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Phe Ser His His Ser Ala
            340                 345                 350         
Trp Leu Val Val Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Asp Glu
        355                 360                 365             
Ala Gly Ser Val Tyr Ala Gly Ile Leu Ser Tyr Gly Val Gly Phe Phe
    370                 375                 380                 
Leu Phe Ile Leu Val Val Ala Ala Val Thr Leu Cys Arg Leu Arg Ser
385                 390                 395                 400 
Pro Pro Lys Lys Gly Leu Gly Ser Pro Thr Val His Lys Ile Ser Arg
                405                 410                 415     
Phe Pro Leu Lys Arg Gln Val Ser Leu Glu Ser Asn Ala Ser Met Ser
            420                 425                 430         
Ser Asn Thr Pro Leu Val Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly
        435                 440                 445             
Pro Thr Leu Ala Asn Val Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys
    450                 455                 460                 
Trp Glu Leu Ser Arg Ala Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu
465                 470                 475                 480 
Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Ile Gly Ile Asp Lys
                485                 490                 495     
Asp Arg Ala Ala Lys Pro Val Thr Val Ala Val Lys Met Leu Lys Asp
            500                 505                 510         
Asp Ala Thr Asp Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met
        515                 520                 525             
Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala
    530                 535                 540                 
Cys Thr Gln Gly Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys
545                 550                 555                 560 
Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro Gly Leu Asp
                565                 570                 575     
Tyr Ser Phe Asp Thr Cys Lys Pro Pro Glu Glu Gln Leu Thr Phe Lys
            580                 585                 590         
Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu
        595                 600                 605             
Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu
    610                 615                 620                 
Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg
625                 630                 635                 640 
Asp Val His Asn Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu
                645                 650                 655     
Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr
            660                 665                 670         
His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe
        675                 680                 685             
Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe
    690                 695                 700                 
Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr
705                 710                 715                 720 
His Asp Leu Tyr Met Ile Met Arg Glu Cys Trp His Ala Ala Pro Ser
                725                 730                 735     
Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Val Leu
            740                 745                 750         
Thr Val Thr Ser Thr Asp Glu Tyr Leu Asp Leu Ser Ala Pro Phe Glu
        755                 760                 765             
Gln Tyr Ser Pro Gly Gly Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly
    770                 775                 780                 
Asp Asp Ser Val Phe Ala His Asp Leu Leu Pro Pro Ala Pro Pro Ser
785                 790                 795                 800 
Ser Gly Gly Ser Arg Thr
                805     


<210> 83
<211> 553
<212> PRT
<213> Homo sapiens

<400> 83
Met Ala Ala Pro Ala Gly Gly Gly Gly Ser Ala Val Ser Val Leu Ala
 1               5                  10                  15      
Pro Asn Gly Arg Arg His Thr Val Lys Val Thr Pro Ser Thr Val Leu
            20                  25                  30          
Leu Gln Val Leu Glu Asp Thr Cys Arg Arg Gln Asp Phe Asn Pro Cys
        35                  40                  45              
Glu Tyr Asp Leu Lys Phe Gln Arg Ser Val Leu Asp Leu Ser Leu Gln
    50                  55                  60                  
Trp Arg Phe Ala Asn Leu Pro Asn Asn Ala Lys Leu Glu Met Val Pro
65                  70                  75                  80  
Ala Ser Arg Ser Arg Glu Gly Pro Glu Asn Met Val Arg Ile Ala Leu
                85                  90                  95      
Gln Leu Asp Asp Gly Ser Arg Leu Gln Asp Ser Phe Cys Ser Gly Gln
            100                 105                 110         
Thr Leu Trp Glu Leu Leu Ser His Phe Pro Gln Ile Arg Glu Cys Leu
        115                 120                 125             
Gln His Pro Gly Gly Ala Thr Pro Val Cys Val Tyr Thr Arg Asp Glu
    130                 135                 140                 
Val Thr Gly Glu Ala Ala Leu Arg Gly Thr Thr Leu Gln Ser Leu Gly
145                 150                 155                 160 
Leu Thr Gly Gly Ser Ala Thr Ile Arg Phe Val Met Lys Cys Tyr Asp
                165                 170                 175     
Pro Val Gly Lys Thr Pro Gly Ser Leu Gly Ser Ser Ala Ser Ala Gly
            180                 185                 190         
Gln Ala Ala Ala Ser Ala Pro Leu Pro Leu Glu Ser Gly Glu Leu Ser
        195                 200                 205             
Arg Gly Asp Leu Ser Arg Pro Glu Asp Ala Asp Thr Ser Gly Pro Cys
    210                 215                 220                 
Cys Glu His Thr Gln Glu Lys Gln Ser Thr Arg Ala Pro Ala Ala Ala
225                 230                 235                 240 
Pro Phe Val Pro Phe Ser Gly Gly Gly Gln Arg Gln Gly Gly Pro Pro
                245                 250                 255     
Gly Pro Thr Arg Pro Leu Thr Ser Ser Ser Ala Lys Leu Pro Lys Ser
            260                 265                 270         
Leu Ser Ser Pro Gly Gly Pro Ser Lys Pro Lys Lys Ser Lys Ser Gly
        275                 280                 285             
Gln Asp Pro Gln Gln Glu Gln Glu Gln Glu Arg Glu Arg Asp Pro Gln
    290                 295                 300                 
Gln Glu Gln Glu Arg Glu Arg Pro Val Asp Arg Glu Pro Val Asp Arg
305                 310                 315                 320 
Glu Pro Val Val Cys His Pro Asp Leu Glu Glu Arg Leu Gln Ala Trp
                325                 330                 335     
Pro Ala Glu Leu Pro Asp Glu Phe Phe Glu Leu Thr Val Asp Asp Val
            340                 345                 350         
Arg Arg Arg Leu Ala Gln Leu Lys Ser Glu Arg Lys Arg Leu Glu Glu
        355                 360                 365             
Ala Pro Leu Val Thr Lys Ala Phe Arg Glu Ala Gln Ile Lys Glu Lys
    370                 375                 380                 
Leu Glu Arg Tyr Pro Lys Val Ala Leu Arg Val Leu Phe Pro Asp Arg
385                 390                 395                 400 
Tyr Val Leu Gln Gly Phe Phe Arg Pro Ser Glu Thr Val Gly Asp Leu
                405                 410                 415     
Arg Asp Phe Val Arg Ser His Leu Gly Asn Pro Glu Leu Ser Phe Tyr
            420                 425                 430         
Leu Phe Ile Thr Pro Pro Lys Thr Val Leu Asp Asp His Thr Gln Thr
        435                 440                 445             
Leu Phe Gln Ala Asn Leu Phe Pro Ala Ala Leu Val His Leu Gly Ala
    450                 455                 460                 
Glu Glu Pro Ala Gly Val Tyr Leu Glu Pro Gly Leu Leu Glu His Ala
465                 470                 475                 480 
Ile Ser Pro Ser Ala Ala Asp Val Leu Val Ala Arg Tyr Met Ser Arg
                485                 490                 495     
Ala Ala Gly Ser Pro Ser Pro Leu Pro Ala Pro Asp Pro Ala Pro Lys
            500                 505                 510         
Ser Glu Pro Ala Ala Glu Glu Gly Ala Leu Val Pro Pro Glu Pro Ile
        515                 520                 525             
Pro Gly Thr Ala Gln Pro Val Lys Arg Ser Leu Gly Lys Val Pro Lys
    530                 535                 540                 
Trp Leu Lys Leu Pro Ala Ser Lys Arg
545                 550             


<210> 84
<211> 204
<212> PRT
<213> Homo sapiens

<400> 84
Met Glu Ala Ala Gly Ser Pro Ala Ala Thr Glu Thr Gly Lys Tyr Ile
 1               5                  10                  15      
Ala Ser Thr Gln Arg Pro Asp Gly Thr Trp Arg Lys Gln Arg Arg Val
            20                  25                  30          
Lys Glu Gly Tyr Val Pro Gln Glu Glu Val Pro Val Tyr Glu Asn Lys
        35                  40                  45              
Tyr Val Lys Phe Phe Lys Ser Lys Pro Glu Leu Pro Pro Gly Leu Ser
    50                  55                  60                  
Pro Glu Ala Thr Ala Pro Val Thr Pro Ser Arg Pro Glu Gly Gly Glu
65                  70                  75                  80  
Pro Gly Leu Ser Lys Thr Ala Lys Arg Asn Leu Lys Arg Lys Glu Lys
                85                  90                  95      
Arg Arg Gln Gln Gln Glu Lys Gly Glu Ala Glu Ala Leu Ser Arg Thr
            100                 105                 110         
Leu Asp Lys Val Ser Leu Glu Glu Thr Ala Gln Leu Pro Ser Ala Pro
        115                 120                 125             
Gln Gly Ser Arg Ala Ala Pro Thr Ala Ala Ser Asp Gln Pro Asp Ser
    130                 135                 140                 
Ala Ala Thr Thr Glu Lys Ala Lys Lys Ile Lys Asn Leu Lys Lys Lys
145                 150                 155                 160 
Leu Arg Gln Val Glu Glu Leu Gln Gln Arg Ile Gln Ala Gly Glu Val
                165                 170                 175     
Ser Gln Pro Ser Lys Glu Gln Leu Glu Lys Leu Ala Arg Arg Arg Ala
            180                 185                 190         
Leu Glu Glu Glu Leu Glu Asp Leu Glu Leu Gly Leu
        195                 200                 


<210> 85
<211> 354
<212> PRT
<213> Homo sapiens

<400> 85
Met Cys Gly Arg Thr Ser Cys His Leu Pro Arg Asp Val Leu Thr Arg
 1               5                  10                  15      
Ala Cys Ala Tyr Gln Asp Arg Arg Gly Gln Gln Arg Leu Pro Glu Trp
            20                  25                  30          
Arg Asp Pro Asp Lys Tyr Cys Pro Ser Tyr Asn Lys Ser Pro Gln Ser
        35                  40                  45              
Asn Ser Pro Val Leu Leu Ser Arg Leu His Phe Asp Lys Asp Ala Asp
    50                  55                  60                  
Ser Ser Glu Arg Ile Ile Ala Pro Met Arg Trp Gly Leu Val Pro Ser
65                  70                  75                  80  
Trp Phe Lys Glu Ser Asp Pro Ser Lys Leu Gln Phe Asn Thr Thr Asn
                85                  90                  95      
Cys Arg Ser Asp Thr Val Met Glu Lys Arg Ser Phe Lys Val Pro Leu
            100                 105                 110         
Gly Lys Gly Arg Arg Cys Val Val Leu Ala Asp Gly Phe Tyr Glu Trp
        115                 120                 125             
Gln Arg Cys Gln Gly Thr Asn Gln Arg Gln Pro Tyr Phe Ile Tyr Phe
    130                 135                 140                 
Pro Gln Ile Lys Thr Glu Lys Ser Gly Ser Ile Gly Ala Ala Asp Ser
145                 150                 155                 160 
Pro Glu Asn Trp Glu Lys Val Trp Asp Asn Trp Arg Leu Leu Thr Met
                165                 170                 175     
Ala Gly Ile Phe Asp Cys Trp Glu Pro Pro Glu Gly Gly Asp Val Leu
            180                 185                 190         
Tyr Ser Tyr Thr Ile Ile Thr Val Asp Ser Cys Lys Gly Leu Ser Asp
        195                 200                 205             
Ile His His Arg Met Pro Ala Ile Leu Asp Gly Glu Glu Ala Val Ser
    210                 215                 220                 
Lys Trp Leu Asp Phe Gly Glu Val Ser Thr Gln Glu Ala Leu Lys Leu
225                 230                 235                 240 
Ile His Pro Thr Glu Asn Ile Thr Phe His Ala Val Ser Ser Val Val
                245                 250                 255     
Asn Asn Ser Arg Asn Asn Thr Pro Glu Cys Leu Ala Pro Val Asp Leu
            260                 265                 270         
Val Val Lys Lys Glu Leu Arg Ala Ser Gly Ser Ser Gln Arg Met Leu
        275                 280                 285             
Gln Trp Leu Ala Thr Lys Ser Pro Lys Lys Glu Asp Ser Lys Thr Pro
    290                 295                 300                 
Gln Lys Glu Glu Ser Asp Val Pro Gln Trp Ser Ser Gln Phe Leu Gln
305                 310                 315                 320 
Lys Ser Pro Leu Pro Thr Lys Arg Gly Thr Ala Gly Leu Leu Glu Gln
                325                 330                 335     
Trp Leu Lys Arg Glu Lys Glu Glu Glu Pro Val Ala Lys Arg Pro Tyr
            340                 345                 350         
Ser Gln
        


<210> 86
<211> 468
<212> PRT
<213> Homo sapiens

<400> 86
Met Ala Lys Arg Asn Ala Glu Lys Glu Leu Thr Asp Arg Asn Trp Asp
 1               5                  10                  15      
Gln Glu Asp Glu Ala Glu Glu Val Gly Thr Phe Ser Met Ala Ser Glu
            20                  25                  30          
Glu Val Leu Lys Asn Arg Ala Ile Lys Lys Ala Lys Arg Arg Asn Val
        35                  40                  45              
Gly Phe Glu Ser Asp Thr Gly Gly Ala Phe Lys Gly Phe Lys Gly Leu
    50                  55                  60                  
Val Val Pro Ser Gly Gly Gly Arg Phe Ser Gly Phe Gly Ser Gly Ala
65                  70                  75                  80  
Gly Gly Lys Pro Leu Glu Gly Leu Ser Asn Gly Asn Asn Ile Thr Ser
                85                  90                  95      
Ala Pro Pro Phe Ala Ser Ala Lys Ala Ala Ala Asp Pro Lys Val Ala
            100                 105                 110         
Phe Gly Ser Leu Ala Ala Asn Gly Pro Thr Thr Leu Val Asp Lys Val
        115                 120                 125             
Ser Asn Pro Lys Thr Asn Gly Asp Ser Gln Gln Pro Ser Ser Ser Gly
    130                 135                 140                 
Leu Ala Ser Ser Lys Ala Cys Val Gly Asn Ala Tyr His Lys Gln Leu
145                 150                 155                 160 
Ala Ala Leu Asn Cys Ser Val Arg Asp Trp Ile Val Lys His Val Asn
                165                 170                 175     
Thr Asn Pro Leu Cys Asp Leu Thr Pro Ile Phe Lys Asp Tyr Glu Lys
            180                 185                 190         
Tyr Leu Ala Asn Ile Glu Gln Gln His Gly Asn Ser Gly Arg Asn Ser
        195                 200                 205             
Glu Ser Glu Ser Asn Lys Val Ala Ala Glu Thr Gln Ser Pro Ser Leu
    210                 215                 220                 
Phe Gly Ser Thr Lys Leu Gln Gln Glu Ser Thr Phe Leu Phe His Gly
225                 230                 235                 240 
Asn Lys Thr Glu Asp Thr Pro Asp Lys Lys Met Glu Val Ala Ser Glu
                245                 250                 255     
Lys Lys Thr Asp Pro Ser Ser Leu Gly Ala Thr Ser Ala Ser Phe Asn
            260                 265                 270         
Phe Gly Lys Lys Val Asp Ser Ser Val Leu Gly Ser Leu Ser Ser Val
        275                 280                 285             
Pro Leu Thr Gly Phe Ser Phe Ser Pro Gly Asn Ser Ser Leu Phe Gly
    290                 295                 300                 
Lys Asp Thr Thr Gln Ser Lys Pro Val Ser Ser Pro Phe Pro Thr Lys
305                 310                 315                 320 
Pro Leu Glu Gly Gln Ala Glu Gly Asp Ser Gly Glu Cys Lys Gly Gly
                325                 330                 335     
Asp Glu Glu Glu Asn Asp Glu Pro Pro Lys Val Val Val Thr Glu Val
            340                 345                 350         
Lys Glu Glu Asp Ala Phe Tyr Ser Lys Lys Cys Lys Leu Phe Tyr Lys
        355                 360                 365             
Lys Asp Asn Glu Phe Lys Glu Lys Gly Ile Gly Thr Leu His Leu Lys
    370                 375                 380                 
Pro Thr Ala Asn Gln Lys Thr Gln Leu Leu Val Arg Ala Asp Thr Asn
385                 390                 395                 400 
Leu Gly Asn Ile Leu Leu Asn Val Leu Ile Pro Pro Asn Met Pro Cys
                405                 410                 415     
Thr Arg Thr Gly Lys Asn Asn Val Leu Ile Val Cys Val Pro Asn Pro
            420                 425                 430         
Pro Ile Asp Glu Lys Asn Ala Thr Met Pro Val Thr Met Leu Ile Arg
        435                 440                 445             
Val Lys Thr Ser Glu Asp Ala Asp Glu Leu His Lys Ile Leu Leu Glu
    450                 455                 460                 
Lys Lys Asp Ala
465             


<210> 87
<211> 1130
<212> PRT
<213> Homo sapiens

<400> 87
Met Leu Glu Ile Cys Leu Lys Leu Val Gly Cys Lys Ser Lys Lys Gly
 1               5                  10                  15      
Leu Ser Ser Ser Ser Ser Cys Tyr Leu Glu Glu Ala Leu Gln Arg Pro
            20                  25                  30          
Val Ala Ser Asp Phe Glu Pro Gln Gly Leu Ser Glu Ala Ala Arg Trp
        35                  40                  45              
Asn Ser Lys Glu Asn Leu Leu Ala Gly Pro Ser Glu Asn Asp Pro Asn
    50                  55                  60                  
Leu Phe Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Thr Leu
65                  70                  75                  80  
Ser Ile Thr Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn His Asn
                85                  90                  95      
Gly Glu Trp Cys Glu Ala Gln Thr Lys Asn Gly Gln Gly Trp Val Pro
            100                 105                 110         
Ser Asn Tyr Ile Thr Pro Val Asn Ser Leu Glu Lys His Ser Trp Tyr
        115                 120                 125             
His Gly Pro Val Ser Arg Asn Ala Ala Glu Tyr Leu Leu Ser Ser Gly
    130                 135                 140                 
Ile Asn Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro Gly Gln
145                 150                 155                 160 
Arg Ser Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile
                165                 170                 175     
Asn Thr Ala Ser Asp Gly Lys Leu Tyr Val Ser Ser Glu Ser Arg Phe
            180                 185                 190         
Asn Thr Leu Ala Glu Leu Val His His His Ser Thr Val Ala Asp Gly
        195                 200                 205             
Leu Ile Thr Thr Leu His Tyr Pro Ala Pro Lys Arg Asn Lys Pro Thr
    210                 215                 220                 
Val Tyr Gly Val Ser Pro Asn Tyr Asp Lys Trp Glu Met Glu Arg Thr
225                 230                 235                 240 
Asp Ile Thr Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val
                245                 250                 255     
Tyr Glu Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val Lys Thr
            260                 265                 270         
Leu Lys Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala
        275                 280                 285             
Val Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val
    290                 295                 300                 
Cys Thr Arg Glu Pro Pro Phe Tyr Ile Ile Thr Glu Phe Met Thr Tyr
305                 310                 315                 320 
Gly Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Gln Glu Val Asn
                325                 330                 335     
Ala Val Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala Met Glu
            340                 345                 350         
Tyr Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn
        355                 360                 365             
Cys Leu Val Gly Glu Asn His Leu Val Lys Val Ala Asp Phe Gly Leu
    370                 375                 380                 
Ser Arg Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly Ala Lys
385                 390                 395                 400 
Phe Pro Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn Lys Phe
                405                 410                 415     
Ser Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile
            420                 425                 430         
Ala Thr Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val
        435                 440                 445             
Tyr Glu Leu Leu Glu Lys Asp Tyr Arg Met Glu Arg Pro Glu Gly Cys
    450                 455                 460                 
Pro Glu Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Gln Trp Asn Pro
465                 470                 475                 480 
Ser Asp Arg Pro Ser Phe Ala Glu Ile His Gln Ala Phe Glu Thr Met
                485                 490                 495     
Phe Gln Glu Ser Ser Ile Ser Asp Glu Val Glu Lys Glu Leu Gly Lys
            500                 505                 510         
Gln Gly Val Arg Gly Ala Val Ser Thr Leu Leu Gln Ala Pro Glu Leu
        515                 520                 525             
Pro Thr Lys Thr Arg Thr Ser Arg Arg Ala Ala Glu His Arg Asp Thr
    530                 535                 540                 
Thr Asp Val Pro Glu Met Pro His Ser Lys Gly Gln Gly Glu Ser Asp
545                 550                 555                 560 
Pro Leu Asp His Glu Pro Ala Val Ser Pro Leu Leu Pro Arg Lys Glu
                565                 570                 575     
Arg Gly Pro Pro Glu Gly Gly Leu Asn Glu Asp Glu Arg Leu Leu Pro
            580                 585                 590         
Lys Asp Lys Lys Thr Asn Leu Phe Ser Ala Leu Ile Lys Lys Lys Lys
        595                 600                 605             
Lys Thr Ala Pro Thr Pro Pro Lys Arg Ser Ser Ser Phe Arg Glu Met
    610                 615                 620                 
Asp Gly Gln Pro Glu Arg Arg Gly Ala Gly Glu Glu Glu Gly Arg Asp
625                 630                 635                 640 
Ile Ser Asn Gly Ala Leu Ala Phe Thr Pro Leu Asp Thr Ala Asp Pro
                645                 650                 655     
Ala Lys Ser Pro Lys Pro Ser Asn Gly Ala Gly Val Pro Asn Gly Ala
            660                 665                 670         
Leu Arg Glu Ser Gly Gly Ser Gly Phe Arg Ser Pro His Leu Trp Lys
        675                 680                 685             
Lys Ser Ser Thr Leu Thr Ser Ser Arg Leu Ala Thr Gly Glu Glu Glu
    690                 695                 700                 
Gly Gly Gly Ser Ser Ser Lys Arg Phe Leu Arg Ser Cys Ser Ala Ser
705                 710                 715                 720 
Cys Val Pro His Gly Ala Lys Asp Thr Glu Trp Arg Ser Val Thr Leu
                725                 730                 735     
Pro Arg Asp Leu Gln Ser Thr Gly Arg Gln Phe Asp Ser Ser Thr Phe
            740                 745                 750         
Gly Gly His Lys Ser Glu Lys Pro Ala Leu Pro Arg Lys Arg Ala Gly
        755                 760                 765             
Glu Asn Arg Ser Asp Gln Val Thr Arg Gly Thr Val Thr Pro Pro Pro
    770                 775                 780                 
Arg Leu Val Lys Lys Asn Glu Glu Ala Ala Asp Glu Val Phe Lys Asp
785                 790                 795                 800 
Ile Met Glu Ser Ser Pro Gly Ser Ser Pro Pro Asn Leu Thr Pro Lys
                805                 810                 815     
Pro Leu Arg Arg Gln Val Thr Val Ala Pro Ala Ser Gly Leu Pro His
            820                 825                 830         
Lys Glu Glu Ala Gly Lys Gly Ser Ala Leu Gly Thr Pro Ala Ala Ala
        835                 840                 845             
Glu Pro Val Thr Pro Thr Ser Lys Ala Gly Ser Gly Ala Pro Gly Gly
    850                 855                 860                 
Thr Ser Lys Gly Pro Ala Glu Glu Ser Arg Val Arg Arg His Lys His
865                 870                 875                 880 
Ser Ser Glu Ser Pro Gly Arg Asp Lys Gly Lys Leu Ser Arg Leu Lys
                885                 890                 895     
Pro Ala Pro Pro Pro Pro Pro Ala Ala Ser Ala Gly Lys Ala Gly Gly
            900                 905                 910         
Lys Pro Ser Gln Ser Pro Ser Gln Glu Ala Ala Gly Glu Ala Val Leu
        915                 920                 925             
Gly Ala Lys Thr Lys Ala Thr Ser Leu Val Asp Ala Val Asn Ser Asp
    930                 935                 940                 
Ala Ala Lys Pro Ser Gln Pro Gly Glu Gly Leu Lys Lys Pro Val Leu
945                 950                 955                 960 
Pro Ala Thr Pro Lys Pro Gln Ser Ala Lys Pro Ser Gly Thr Pro Ile
                965                 970                 975     
Ser Pro Ala Pro Val Pro Ser Thr Leu Pro Ser Ala Ser Ser Ala Leu
            980                 985                 990         
Ala Gly Asp Gln Pro Ser Ser Thr Ala Phe Ile Pro Leu Ile Ser Thr
        995                 1000                1005            
Arg Val Ser Leu Arg Lys Thr Arg Gln Pro Pro Glu Arg Ile Ala Ser
    1010                1015                1020                
Gly Ala Ile Thr Lys Gly Val Val Leu Asp Ser Thr Glu Ala Leu Cys
1025                1030                1035               1040 
Leu Ala Ile Ser Arg Asn Ser Glu Gln Met Ala Ser His Ser Ala Val
                1045                1050                1055    
Leu Glu Ala Gly Lys Asn Leu Tyr Thr Phe Cys Val Ser Tyr Val Asp
            1060                1065                1070        
Ser Ile Gln Gln Met Arg Asn Lys Phe Ala Phe Arg Glu Ala Ile Asn
        1075                1080                1085            
Lys Leu Glu Asn Asn Leu Arg Glu Leu Gln Ile Cys Pro Ala Thr Ala
    1090                1095                1100                
Gly Ser Gly Pro Ala Ala Thr Gln Asp Phe Ser Lys Leu Leu Ser Ser
1105                1110                1115               1120 
Val Lys Glu Ile Ser Asp Ile Val Gln Arg
                1125                1130


<210> 88
<211> 209
<212> PRT
<213> Homo sapiens

<400> 88
Met Lys Phe Lys Leu His Val Asn Ser Ala Arg Gln Tyr Lys Asp Leu
 1               5                  10                  15      
Trp Asn Met Ser Asp Asp Lys Pro Phe Leu Cys Thr Ala Pro Gly Cys
            20                  25                  30          
Gly Gln Arg Phe Thr Asn Glu Asp His Leu Ala Val His Lys His Lys
        35                  40                  45              
His Glu Met Thr Leu Lys Phe Gly Pro Ala Arg Asn Asp Ser Val Ile
    50                  55                  60                  
Val Ala Asp Gln Thr Pro Thr Pro Thr Arg Phe Leu Lys Asn Cys Glu
65                  70                  75                  80  
Glu Val Gly Leu Phe Asn Glu Leu Ala Ser Pro Phe Glu Asn Glu Phe
                85                  90                  95      
Lys Lys Ala Ser Glu Asp Asp Ile Lys Lys Met Pro Leu Asp Leu Ser
            100                 105                 110         
Pro Leu Ala Thr Pro Ile Ile Arg Ser Lys Ile Glu Glu Pro Ser Val
        115                 120                 125             
Val Glu Thr Thr His Gln Asp Ser Pro Leu Pro His Pro Glu Ser Thr
    130                 135                 140                 
Thr Ser Asp Glu Lys Glu Val Pro Leu Ala Gln Thr Ala Gln Pro Thr
145                 150                 155                 160 
Ser Ala Ile Val Arg Pro Ala Ser Leu Gln Val Pro Asn Val Leu Leu
                165                 170                 175     
Thr Ser Ser Asp Ser Ser Val Ile Ile Gln Gln Ala Val Pro Ser Pro
            180                 185                 190         
Thr Ser Ser Thr Val Ile Thr Gln Ala Pro Ser Ser Asn Arg Pro Ile
        195                 200                 205             
Val
    


<210> 89
<211> 505
<212> PRT
<213> Homo sapiens

<400> 89
Met Lys Phe Lys Leu His Val Asn Ser Ala Arg Gln Tyr Lys Asp Leu
 1               5                  10                  15      
Trp Asn Met Ser Asp Asp Lys Pro Phe Leu Cys Thr Ala Pro Gly Cys
            20                  25                  30          
Gly Gln Arg Phe Thr Asn Glu Asp His Leu Ala Val His Lys His Lys
        35                  40                  45              
His Glu Met Thr Leu Lys Phe Gly Pro Ala Arg Asn Asp Ser Val Ile
    50                  55                  60                  
Val Ala Asp Gln Thr Pro Thr Pro Thr Arg Phe Leu Lys Asn Cys Glu
65                  70                  75                  80  
Glu Val Gly Leu Phe Asn Glu Leu Ala Ser Pro Phe Glu Asn Glu Phe
                85                  90                  95      
Lys Lys Ala Ser Glu Asp Asp Ile Lys Lys Met Pro Leu Asp Leu Ser
            100                 105                 110         
Pro Leu Ala Thr Pro Ile Ile Arg Ser Lys Ile Glu Glu Pro Ser Val
        115                 120                 125             
Val Glu Thr Thr His Gln Asp Ser Pro Leu Pro His Pro Glu Ser Thr
    130                 135                 140                 
Thr Ser Asp Glu Lys Glu Val Pro Leu Ala Gln Thr Ala Gln Pro Thr
145                 150                 155                 160 
Ser Ala Ile Val Arg Pro Ala Ser Leu Gln Val Pro Asn Val Leu Leu
                165                 170                 175     
Thr Ser Ser Asp Ser Ser Val Ile Ile Gln Gln Ala Val Pro Ser Pro
            180                 185                 190         
Thr Ser Ser Thr Val Ile Thr Gln Ala Pro Ser Ser Asn Arg Pro Ile
        195                 200                 205             
Val Pro Val Pro Gly Pro Phe Pro Leu Leu Leu His Leu Pro Asn Gly
    210                 215                 220                 
Gln Thr Met Pro Val Ala Ile Pro Ala Ser Ile Thr Ser Ser Asn Val
225                 230                 235                 240 
His Val Pro Ala Ala Val Pro Leu Val Arg Pro Val Thr Met Val Pro
                245                 250                 255     
Ser Val Pro Gly Ile Pro Gly Pro Ser Ser Pro Gln Pro Val Gln Ser
            260                 265                 270         
Glu Ala Lys Met Arg Leu Lys Ala Ala Leu Thr Gln Gln His Pro Pro
        275                 280                 285             
Val Thr Asn Gly Asp Thr Val Lys Gly His Gly Ser Gly Leu Val Arg
    290                 295                 300                 
Thr Gln Ser Glu Glu Ser Arg Pro Gln Ser Leu Gln Gln Pro Ala Thr
305                 310                 315                 320 
Ser Thr Thr Glu Thr Pro Ala Ser Pro Ala His Thr Thr Pro Gln Thr
                325                 330                 335     
Gln Ser Thr Ser Gly Arg Arg Arg Arg Ala Ala Asn Glu Asp Pro Asp
            340                 345                 350         
Glu Lys Arg Arg Lys Phe Leu Glu Arg Asn Arg Ala Ala Ala Ser Arg
        355                 360                 365             
Cys Arg Gln Lys Arg Lys Val Trp Val Gln Ser Leu Glu Lys Lys Ala
    370                 375                 380                 
Glu Asp Leu Ser Ser Leu Asn Gly Gln Leu Gln Ser Glu Val Thr Leu
385                 390                 395                 400 
Leu Arg Asn Glu Val Ala Gln Leu Lys Gln Leu Leu Leu Ala His Lys
                405                 410                 415     
Asp Cys Pro Val Thr Ala Met Gln Lys Lys Ser Gly Tyr His Thr Ala
            420                 425                 430         
Asp Lys Asp Asp Ser Ser Glu Asp Ile Ser Val Pro Ser Ser Pro His
        435                 440                 445             
Thr Glu Ala Ile Gln His Ser Ser Val Ser Thr Ser Asn Gly Val Ser
    450                 455                 460                 
Ser Thr Ser Lys Ala Glu Ala Val Ala Thr Ser Val Leu Thr Gln Met
465                 470                 475                 480 
Ala Asp Gln Ser Thr Glu Pro Ala Leu Ser Gln Ile Val Met Ala Pro
                485                 490                 495     
Ser Ser Gln Ser Gln Pro Ser Gly Ser
            500                 505 


<210> 90
<211> 545
<212> PRT
<213> Homo sapiens

<400> 90
Met Ser Asn Asn Gly Leu Asp Ile Gln Asp Lys Pro Pro Ala Pro Pro
 1               5                  10                  15      
Met Arg Asn Thr Ser Thr Met Ile Gly Ala Gly Ser Lys Asp Ala Gly
            20                  25                  30          
Thr Leu Asn His Gly Ser Lys Pro Leu Pro Pro Asn Pro Glu Glu Lys
        35                  40                  45              
Lys Lys Lys Asp Arg Phe Tyr Arg Ser Ile Leu Pro Gly Asp Lys Thr
    50                  55                  60                  
Asn Lys Lys Lys Glu Lys Glu Arg Pro Glu Ile Ser Leu Pro Ser Asp
65                  70                  75                  80  
Phe Glu His Thr Ile His Val Gly Phe Asp Ala Val Thr Gly Glu Phe
                85                  90                  95      
Thr Gly Met Pro Glu Gln Trp Ala Arg Leu Leu Gln Thr Ser Asn Ile
            100                 105                 110         
Thr Lys Ser Glu Gln Lys Lys Asn Pro Gln Ala Val Leu Asp Val Leu
        115                 120                 125             
Glu Phe Tyr Asn Ser Lys Lys Thr Ser Asn Ser Gln Lys Tyr Met Ser
    130                 135                 140                 
Phe Thr Asp Lys Ser Ala Glu Asp Tyr Asn Ser Ser Asn Ala Leu Asn
145                 150                 155                 160 
Val Lys Ala Val Ser Glu Thr Pro Ala Val Pro Pro Val Ser Glu Asp
                165                 170                 175     
Glu Asp Asp Asp Asp Asp Asp Ala Thr Pro Pro Pro Val Ile Ala Pro
            180                 185                 190         
Arg Pro Glu His Thr Lys Ser Val Tyr Thr Arg Ser Val Ile Glu Pro
        195                 200                 205             
Leu Pro Val Thr Pro Thr Arg Asp Val Ala Thr Ser Pro Ile Ser Pro
    210                 215                 220                 
Thr Glu Asn Asn Thr Thr Pro Pro Asp Ala Leu Thr Arg Asn Thr Glu
225                 230                 235                 240 
Lys Gln Lys Lys Lys Pro Lys Met Ser Asp Glu Glu Ile Leu Glu Lys
                245                 250                 255     
Leu Arg Ser Ile Val Ser Val Gly Asp Pro Lys Lys Lys Tyr Thr Arg
            260                 265                 270         
Phe Glu Lys Ile Gly Gln Gly Ala Ser Gly Thr Val Tyr Thr Ala Met
        275                 280                 285             
Asp Val Ala Thr Gly Gln Glu Val Ala Ile Lys Gln Met Asn Leu Gln
    290                 295                 300                 
Gln Gln Pro Lys Lys Glu Leu Ile Ile Asn Glu Ile Leu Val Met Arg
305                 310                 315                 320 
Glu Asn Lys Asn Pro Asn Ile Val Asn Tyr Leu Asp Ser Tyr Leu Val
                325                 330                 335     
Gly Asp Glu Leu Trp Val Val Met Glu Tyr Leu Ala Gly Gly Ser Leu
            340                 345                 350         
Thr Asp Val Val Thr Glu Thr Cys Met Asp Glu Gly Gln Ile Ala Ala
        355                 360                 365             
Val Cys Arg Glu Cys Leu Gln Ala Leu Glu Phe Leu His Ser Asn Gln
    370                 375                 380                 
Val Ile His Arg Asp Ile Lys Ser Asp Asn Ile Leu Leu Gly Met Asp
385                 390                 395                 400 
Gly Ser Val Lys Leu Thr Asp Phe Gly Phe Cys Ala Gln Ile Thr Pro
                405                 410                 415     
Glu Gln Ser Lys Arg Ser Thr Met Val Gly Thr Pro Tyr Trp Met Ala
            420                 425                 430         
Pro Glu Val Val Thr Arg Lys Ala Tyr Gly Pro Lys Val Asp Ile Trp
        435                 440                 445             
Ser Leu Gly Ile Met Ala Ile Glu Met Ile Glu Gly Glu Pro Pro Tyr
    450                 455                 460                 
Leu Asn Glu Asn Pro Leu Arg Ala Leu Tyr Leu Ile Ala Thr Asn Gly
465                 470                 475                 480 
Thr Pro Glu Leu Gln Asn Pro Glu Lys Leu Ser Ala Ile Phe Arg Asp
                485                 490                 495     
Phe Leu Asn Arg Cys Leu Glu Met Asp Val Glu Lys Arg Gly Ser Ala
            500                 505                 510         
Lys Glu Leu Leu Gln His Gln Phe Leu Lys Ile Ala Lys Pro Leu Ser
        515                 520                 525             
Ser Leu Thr Pro Leu Ile Ala Ala Ala Lys Glu Ala Thr Lys Asn Asn
    530                 535                 540                 
His
545 


<210> 91
<211> 586
<212> PRT
<213> Homo sapiens

<400> 91
Met Ser Arg Glu Ser Asp Val Glu Ala Gln Gln Ser His Gly Ser Ser
 1               5                  10                  15      
Ala Cys Ser Gln Pro His Gly Ser Val Thr Gln Ser Gln Gly Ser Ser
            20                  25                  30          
Ser Gln Ser Gln Gly Ile Ser Ser Ser Ser Thr Ser Thr Met Pro Asn
        35                  40                  45              
Ser Ser Gln Ser Ser His Ser Ser Ser Gly Thr Leu Ser Ser Leu Glu
    50                  55                  60                  
Thr Val Ser Thr Gln Glu Leu Tyr Ser Ile Pro Glu Asp Gln Glu Pro
65                  70                  75                  80  
Glu Asp Gln Glu Pro Glu Glu Pro Thr Pro Ala Pro Trp Ala Arg Leu
                85                  90                  95      
Trp Ala Leu Gln Asp Gly Phe Ala Asn Leu Glu Thr Glu Ser Gly His
            100                 105                 110         
Val Thr Gln Ser Asp Leu Glu Leu Leu Leu Ser Ser Asp Pro Pro Ala
        115                 120                 125             
Ser Ala Ser Gln Ser Ala Gly Ile Arg Gly Val Arg His His Pro Arg
    130                 135                 140                 
Pro Val Cys Ser Leu Lys Cys Val Asn Asp Asn Tyr Trp Phe Gly Arg
145                 150                 155                 160 
Asp Lys Ser Cys Glu Tyr Cys Phe Asp Glu Pro Leu Leu Lys Arg Thr
                165                 170                 175     
Asp Lys Tyr Arg Thr Tyr Ser Lys Lys His Phe Arg Ile Phe Arg Glu
            180                 185                 190         
Val Gly Pro Lys Asn Ser Tyr Ile Ala Tyr Ile Glu Asp His Ser Gly
        195                 200                 205             
Asn Gly Thr Phe Val Asn Thr Glu Leu Val Gly Lys Gly Lys Arg Arg
    210                 215                 220                 
Pro Leu Asn Asn Asn Ser Glu Ile Ala Leu Ser Leu Ser Arg Asn Lys
225                 230                 235                 240 
Val Phe Val Phe Phe Asp Leu Thr Val Asp Asp Gln Ser Val Tyr Pro
                245                 250                 255     
Lys Ala Leu Arg Asp Glu Tyr Ile Met Ser Lys Thr Leu Gly Ser Gly
            260                 265                 270         
Ala Cys Gly Glu Val Lys Leu Ala Phe Glu Arg Lys Thr Cys Lys Lys
        275                 280                 285             
Val Ala Ile Lys Ile Ile Ser Lys Arg Lys Phe Ala Ile Gly Ser Ala
    290                 295                 300                 
Arg Glu Ala Asp Pro Ala Leu Asn Val Glu Thr Glu Ile Glu Ile Leu
305                 310                 315                 320 
Lys Lys Leu Asn His Pro Cys Ile Ile Lys Ile Lys Asn Phe Phe Asp
                325                 330                 335     
Ala Glu Asp Tyr Tyr Ile Val Leu Glu Leu Met Glu Gly Gly Glu Leu
            340                 345                 350         
Phe Asp Lys Val Val Gly Asn Lys Arg Leu Lys Glu Ala Thr Cys Lys
        355                 360                 365             
Leu Tyr Phe Tyr Gln Met Leu Leu Ala Val Gln Tyr Leu His Glu Asn
    370                 375                 380                 
Gly Ile Ile His Arg Asp Leu Lys Pro Glu Asn Val Leu Leu Ser Ser
385                 390                 395                 400 
Gln Glu Glu Asp Cys Leu Ile Lys Ile Thr Asp Phe Gly His Ser Lys
                405                 410                 415     
Ile Leu Gly Glu Thr Ser Leu Met Arg Thr Leu Cys Gly Thr Pro Thr
            420                 425                 430         
Tyr Leu Ala Pro Glu Val Leu Val Ser Val Gly Thr Ala Gly Tyr Asn
        435                 440                 445             
Arg Ala Val Asp Cys Trp Ser Leu Gly Val Ile Leu Phe Ile Cys Leu
    450                 455                 460                 
Ser Gly Tyr Pro Pro Phe Ser Glu His Arg Thr Gln Val Ser Leu Lys
465                 470                 475                 480 
Asp Gln Ile Thr Ser Gly Lys Tyr Asn Phe Ile Pro Glu Val Trp Ala
                485                 490                 495     
Glu Val Ser Glu Lys Ala Leu Asp Leu Val Lys Lys Leu Leu Val Val
            500                 505                 510         
Asp Pro Lys Ala Arg Phe Thr Thr Glu Glu Ala Leu Arg His Pro Trp
        515                 520                 525             
Leu Gln Asp Glu Asp Met Lys Arg Lys Phe Gln Asp Leu Leu Ser Glu
    530                 535                 540                 
Glu Asn Glu Ser Thr Ala Leu Pro Gln Val Leu Ala Gln Pro Ser Thr
545                 550                 555                 560 
Ser Arg Lys Arg Pro Arg Glu Gly Glu Ala Glu Gly Ala Glu Thr Thr
                565                 570                 575     
Lys Arg Pro Ala Val Cys Ala Ala Val Leu
            580                 585     


<210> 92
<211> 3267
<212> PRT
<213> Homo sapiens

<400> 92
Met Gln Lys Ala Arg Gly Thr Arg Gly Glu Asp Ala Gly Thr Arg Ala
 1               5                  10                  15      
Pro Pro Ser Pro Gly Val Pro Pro Lys Arg Ala Lys Val Gly Ala Gly
            20                  25                  30          
Gly Gly Ala Pro Val Ala Val Ala Gly Ala Pro Val Phe Leu Arg Pro
        35                  40                  45              
Leu Lys Asn Ala Ala Val Cys Ala Gly Ser Asp Val Arg Leu Arg Val
    50                  55                  60                  
Val Val Ser Gly Thr Pro Gln Pro Ser Leu Arg Trp Phe Arg Asp Gly
65                  70                  75                  80  
Gln Leu Leu Pro Ala Pro Ala Pro Glu Pro Ser Cys Leu Trp Leu Arg
                85                  90                  95      
Arg Cys Gly Ala Gln Asp Ala Gly Val Tyr Ser Cys Met Ala Gln Asn
            100                 105                 110         
Glu Arg Gly Arg Ala Ser Cys Glu Ala Val Leu Thr Val Leu Glu Val
        115                 120                 125             
Gly Asp Ser Glu Thr Ala Glu Asp Asp Ile Ser Asp Val Gln Gly Thr
    130                 135                 140                 
Gln Arg Leu Glu Leu Arg Asp Asp Gly Ala Phe Ser Thr Pro Thr Gly
145                 150                 155                 160 
Gly Ser Asp Thr Leu Val Gly Thr Ser Leu Asp Thr Pro Pro Thr Ser
                165                 170                 175     
Val Thr Gly Thr Ser Glu Glu Gln Val Ser Trp Trp Gly Ser Gly Gln
            180                 185                 190         
Thr Val Leu Glu Gln Glu Ala Gly Ser Gly Gly Gly Thr Arg Arg Leu
        195                 200                 205             
Pro Gly Ser Pro Arg Gln Ala Gln Ala Thr Gly Ala Gly Pro Arg His
    210                 215                 220                 
Leu Gly Val Glu Pro Leu Val Arg Ala Ser Arg Ala Asn Leu Val Gly
225                 230                 235                 240 
Ala Ser Trp Gly Ser Glu Asp Ser Leu Ser Val Ala Ser Asp Leu Tyr
                245                 250                 255     
Gly Ser Ala Phe Ser Leu Tyr Arg Gly Arg Ala Leu Ser Ile His Val
            260                 265                 270         
Ser Val Pro Gln Ser Gly Leu Arg Arg Glu Glu Pro Asp Leu Gln Pro
        275                 280                 285             
Gln Leu Ala Ser Glu Ala Pro Arg Arg Pro Ala Gln Pro Pro Pro Ser
    290                 295                 300                 
Lys Ser Ala Leu Leu Pro Pro Pro Ser Pro Arg Val Gly Lys Arg Ser
305                 310                 315                 320 
Pro Pro Gly Pro Pro Ala Gln Pro Ala Ala Thr Pro Thr Ser Pro His
                325                 330                 335     
Arg Arg Thr Gln Glu Pro Val Leu Pro Glu Asp Thr Thr Thr Glu Glu
            340                 345                 350         
Lys Arg Gly Lys Lys Ser Lys Ser Ser Gly Pro Ser Leu Ala Gly Thr
        355                 360                 365             
Ala Glu Ser Arg Pro Gln Thr Pro Leu Ser Glu Ala Ser Gly Arg Leu
    370                 375                 380                 
Ser Ala Leu Gly Arg Ser Pro Arg Leu Val Arg Ala Gly Ser Arg Ile
385                 390                 395                 400 
Leu Asp Lys Leu Gln Phe Phe Glu Glu Arg Arg Arg Ser Leu Glu Arg
                405                 410                 415     
Ser Asp Ser Pro Pro Ala Pro Leu Arg Pro Trp Val Pro Leu Arg Lys
            420                 425                 430         
Ala Arg Ser Leu Glu Gln Pro Lys Ser Glu Arg Gly Ala Pro Trp Gly
        435                 440                 445             
Thr Pro Gly Ala Ser Gln Glu Glu Leu Arg Ala Pro Gly Ser Val Ala
    450                 455                 460                 
Glu Arg Arg Arg Leu Phe Gln Gln Lys Ala Ala Ser Leu Asp Glu Arg
465                 470                 475                 480 
Thr Arg Gln Arg Ser Pro Ala Ser Asp Leu Glu Leu Arg Phe Ala Gln
                485                 490                 495     
Glu Leu Gly Arg Ile Arg Arg Ser Thr Ser Arg Glu Glu Leu Val Arg
            500                 505                 510         
Ser His Glu Ser Leu Arg Ala Thr Leu Gln Arg Ala Pro Ser Pro Arg
        515                 520                 525             
Glu Pro Gly Glu Pro Pro Leu Phe Ser Arg Pro Ser Thr Pro Lys Thr
    530                 535                 540                 
Ser Arg Ala Val Ser Pro Ala Ala Ala Gln Pro Pro Ser Pro Ser Ser
545                 550                 555                 560 
Ala Glu Lys Pro Gly Asp Glu Pro Gly Arg Pro Arg Ser Arg Gly Pro
                565                 570                 575     
Ala Gly Arg Thr Glu Pro Gly Glu Gly Pro Gln Gln Glu Val Arg Arg
            580                 585                 590         
Arg Asp Gln Phe Pro Leu Thr Arg Ser Arg Ala Ile Gln Glu Cys Arg
        595                 600                 605             
Ser Pro Val Pro Pro Pro Ala Ala Asp Pro Pro Glu Ala Arg Thr Lys
    610                 615                 620                 
Ala Pro Pro Gly Arg Lys Arg Glu Pro Pro Ala Gln Ala Val Arg Phe
625                 630                 635                 640 
Leu Pro Trp Ala Thr Pro Gly Leu Glu Gly Ala Ala Val Pro Gln Thr
                645                 650                 655     
Leu Glu Lys Asn Arg Ala Gly Pro Glu Ala Glu Lys Arg Leu Arg Arg
            660                 665                 670         
Gly Pro Glu Glu Asp Gly Pro Trp Gly Pro Trp Asp Arg Arg Gly Ala
        675                 680                 685             
Arg Ser Gln Gly Lys Gly Arg Arg Ala Arg Pro Thr Ser Pro Glu Leu
    690                 695                 700                 
Glu Ser Ser Asp Asp Ser Tyr Val Ser Ala Gly Glu Glu Pro Leu Glu
705                 710                 715                 720 
Ala Pro Val Phe Glu Ile Pro Leu Gln Asn Val Val Val Ala Pro Gly
                725                 730                 735     
Ala Asp Val Leu Leu Lys Cys Ile Ile Thr Ala Asn Pro Pro Pro Gln
            740                 745                 750         
Val Ser Trp His Lys Asp Gly Ser Ala Leu Arg Ser Glu Gly Arg Leu
        755                 760                 765             
Leu Leu Arg Ala Glu Gly Glu Arg His Thr Leu Leu Leu Arg Glu Ala
    770                 775                 780                 
Arg Ala Ala Asp Ala Gly Ser Tyr Met Ala Thr Ala Thr Asn Glu Leu
785                 790                 795                 800 
Gly Gln Ala Thr Cys Ala Ala Ser Leu Thr Val Arg Pro Gly Gly Ser
                805                 810                 815     
Thr Ser Pro Phe Ser Ser Pro Ile Thr Ser Asp Glu Glu Tyr Leu Ser
            820                 825                 830         
Pro Pro Glu Glu Phe Pro Glu Pro Gly Glu Thr Trp Pro Arg Thr Pro
        835                 840                 845             
Thr Met Lys Pro Ser Pro Ser Gln Asn Arg Arg Ser Ser Asp Thr Gly
    850                 855                 860                 
Ser Lys Ala Pro Pro Thr Phe Lys Val Ser Leu Met Asp Gln Ser Val
865                 870                 875                 880 
Arg Glu Gly Gln Asp Val Ile Met Ser Ile Arg Val Gln Gly Glu Pro
                885                 890                 895     
Lys Pro Val Val Ser Trp Leu Arg Asn Arg Gln Pro Val Arg Pro Asp
            900                 905                 910         
Gln Arg Arg Phe Ala Glu Glu Ala Glu Gly Gly Leu Cys Arg Leu Arg
        915                 920                 925             
Ile Leu Ala Ala Glu Arg Gly Asp Ala Gly Phe Tyr Thr Cys Lys Ala
    930                 935                 940                 
Val Asn Glu Tyr Gly Ala Arg Gln Cys Glu Ala Arg Leu Glu Val Arg
945                 950                 955                 960 
Ala His Pro Glu Ser Arg Ser Leu Ala Val Leu Ala Pro Leu Gln Asp
                965                 970                 975     
Val Asp Val Gly Ala Gly Glu Met Ala Leu Phe Glu Cys Leu Val Ala
            980                 985                 990         
Gly Pro Thr Asp Val Glu Val Asp Trp Leu Cys Arg Gly Arg Leu Leu
        995                 1000                1005            
Gln Pro Ala Leu Leu Lys Cys Lys Met His Phe Asp Gly Arg Lys Cys
    1010                1015                1020                
Lys Leu Leu Leu Thr Ser Val His Glu Asp Asp Ser Gly Val Tyr Thr
1025                1030                1035               1040 
Cys Lys Leu Ser Thr Ala Lys Asp Glu Leu Thr Cys Ser Ala Arg Leu
                1045                1050                1055    
Thr Val Arg Pro Ser Leu Ala Pro Leu Phe Thr Arg Leu Leu Glu Asp
            1060                1065                1070        
Val Glu Val Leu Glu Gly Arg Ala Ala Arg Phe Asp Cys Lys Ile Ser
        1075                1080                1085            
Gly Thr Pro Pro Pro Val Val Thr Trp Thr His Phe Gly Cys Pro Met
    1090                1095                1100                
Glu Glu Ser Glu Asn Leu Arg Leu Arg Gln Asp Gly Gly Leu His Ser
1105                1110                1115               1120 
Leu His Ile Ala His Val Gly Ser Glu Asp Glu Gly Leu Tyr Ala Val
                1125                1130                1135    
Ser Ala Val Asn Thr His Gly Gln Ala His Cys Ser Ala Gln Leu Tyr
            1140                1145                1150        
Val Glu Glu Pro Arg Thr Ala Ala Ser Gly Pro Ser Ser Lys Leu Glu
        1155                1160                1165            
Lys Met Pro Ser Ile Pro Glu Glu Pro Glu Gln Gly Glu Leu Glu Arg
    1170                1175                1180                
Leu Ser Ile Pro Asp Phe Leu Arg Pro Leu Gln Asp Leu Glu Val Gly
1185                1190                1195               1200 
Leu Ala Lys Glu Ala Met Leu Glu Cys Gln Val Thr Gly Leu Pro Tyr
                1205                1210                1215    
Pro Thr Ile Ser Trp Phe His Asn Gly His Arg Ile Gln Ser Ser Asp
            1220                1225                1230        
Asp Arg Arg Met Thr Gln Tyr Arg Asp Val His Arg Leu Val Phe Pro
        1235                1240                1245            
Ala Val Gly Pro Gln His Ala Gly Val Tyr Lys Ser Val Ile Ala Asn
    1250                1255                1260                
Lys Leu Gly Lys Ala Ala Cys Tyr Ala His Leu Tyr Val Thr Asp Val
1265                1270                1275               1280 
Val Pro Gly Pro Pro Asp Gly Ala Pro Gln Val Val Ala Val Thr Gly
                1285                1290                1295    
Arg Met Val Thr Leu Thr Trp Asn Pro Pro Arg Ser Leu Asp Met Ala
            1300                1305                1310        
Ile Asp Pro Asp Ser Leu Thr Tyr Thr Val Gln His Gln Val Leu Gly
        1315                1320                1325            
Ser Asp Gln Trp Thr Ala Leu Val Thr Gly Leu Arg Glu Pro Gly Trp
    1330                1335                1340                
Ala Ala Thr Gly Leu Arg Lys Gly Val Gln His Ile Phe Arg Val Leu
1345                1350                1355               1360 
Ser Thr Thr Val Lys Ser Ser Ser Lys Pro Ser Pro Pro Ser Glu Pro
                1365                1370                1375    
Val Gln Leu Leu Glu His Gly Pro Thr Leu Glu Glu Ala Pro Ala Met
            1380                1385                1390        
Leu Asp Lys Pro Asp Ile Val Tyr Val Val Glu Gly Gln Pro Ala Ser
        1395                1400                1405            
Val Thr Val Thr Phe Asn His Val Glu Ala Gln Val Val Trp Arg Ser
    1410                1415                1420                
Cys Arg Gly Ala Leu Leu Glu Ala Arg Ala Gly Val Tyr Glu Leu Ser
1425                1430                1435               1440 
Gln Pro Asp Asp Asp Gln Tyr Cys Leu Arg Ile Cys Arg Val Ser Arg
                1445                1450                1455    
Arg Asp Met Gly Ala Leu Thr Cys Thr Ala Arg Asn Arg His Gly Thr
            1460                1465                1470        
Gln Thr Cys Ser Val Thr Leu Glu Leu Ala Glu Ala Pro Arg Phe Glu
        1475                1480                1485            
Ser Ile Met Glu Asp Val Glu Val Gly Ala Gly Glu Thr Ala Arg Phe
    1490                1495                1500                
Ala Val Val Val Glu Gly Lys Pro Leu Pro Asp Ile Met Trp Tyr Lys
1505                1510                1515               1520 
Asp Glu Val Leu Leu Thr Glu Ser Ser His Val Ser Phe Val Tyr Glu
                1525                1530                1535    
Glu Asn Glu Cys Ser Leu Val Val Leu Ser Thr Gly Ala Gln Asp Gly
            1540                1545                1550        
Gly Val Tyr Thr Cys Thr Ala Gln Asn Leu Ala Gly Glu Val Ser Cys
        1555                1560                1565            
Lys Ala Glu Leu Ala Val His Ser Ala Gln Thr Ala Met Glu Val Glu
    1570                1575                1580                
Gly Val Gly Glu Asp Glu Asp His Arg Gly Arg Arg Leu Ser Asp Phe
1585                1590                1595               1600 
Tyr Asp Ile His Gln Glu Ile Gly Arg Gly Ala Phe Ser Tyr Leu Arg
                1605                1610                1615    
Arg Ile Val Glu Arg Ser Ser Gly Leu Glu Phe Ala Ala Lys Phe Ile
            1620                1625                1630        
Pro Ser Gln Ala Lys Pro Lys Ala Ser Ala Arg Arg Glu Ala Arg Leu
        1635                1640                1645            
Leu Ala Arg Leu Gln His Asp Cys Val Leu Tyr Phe His Glu Ala Phe
    1650                1655                1660                
Glu Arg Arg Arg Gly Leu Val Ile Val Thr Glu Leu Cys Thr Glu Glu
1665                1670                1675               1680 
Leu Leu Glu Arg Ile Ala Arg Lys Pro Thr Val Cys Glu Ser Glu Ile
                1685                1690                1695    
Arg Ala Tyr Met Arg Gln Val Leu Glu Gly Ile His Tyr Leu His Gln
            1700                1705                1710        
Ser His Val Leu His Leu Asp Val Lys Pro Glu Asn Leu Leu Val Trp
        1715                1720                1725            
Asp Gly Ala Ala Gly Glu Gln Gln Val Arg Ile Cys Asp Phe Gly Asn
    1730                1735                1740                
Ala Gln Glu Leu Thr Pro Gly Glu Pro Gln Tyr Cys Gln Tyr Gly Thr
1745                1750                1755               1760 
Pro Glu Phe Val Ala Pro Glu Ile Val Asn Gln Ser Pro Val Ser Gly
                1765                1770                1775    
Val Thr Asp Ile Trp Pro Val Gly Val Val Ala Phe Leu Cys Leu Thr
            1780                1785                1790        
Gly Ile Ser Pro Phe Val Gly Glu Asn Asp Arg Thr Thr Leu Met Asn
        1795                1800                1805            
Ile Arg Asn Tyr Asn Val Ala Phe Glu Glu Thr Thr Phe Leu Ser Leu
    1810                1815                1820                
Ser Arg Glu Ala Arg Gly Phe Leu Ile Lys Val Leu Val Gln Asp Arg
1825                1830                1835               1840 
Leu Arg Pro Thr Ala Glu Glu Thr Leu Glu His Pro Trp Phe Lys Thr
                1845                1850                1855    
Gln Ala Lys Gly Ala Glu Val Ser Thr Asp His Leu Lys Leu Phe Leu
            1860                1865                1870        
Ser Arg Arg Arg Trp Gln Arg Ser Gln Ile Ser Tyr Lys Cys His Leu
        1875                1880                1885            
Val Leu Arg Pro Ile Pro Glu Leu Leu Arg Ala Pro Pro Glu Arg Val
    1890                1895                1900                
Trp Val Thr Met Pro Arg Arg Pro Pro Pro Ser Gly Gly Leu Ser Ser
1905                1910                1915               1920 
Ser Ser Asp Ser Glu Glu Glu Glu Leu Glu Glu Leu Pro Ser Val Pro
                1925                1930                1935    
Arg Pro Leu Gln Pro Glu Phe Ser Gly Ser Arg Val Ser Leu Thr Asp
            1940                1945                1950        
Ile Pro Thr Glu Asp Glu Ala Leu Gly Thr Pro Glu Thr Gly Ala Ala
        1955                1960                1965            
Thr Pro Met Asp Trp Gln Glu Gln Gly Arg Ala Pro Ser Gln Asp Gln
    1970                1975                1980                
Glu Ala Pro Ser Pro Glu Ala Leu Pro Ser Pro Gly Gln Glu Pro Ala
1985                1990                1995               2000 
Ala Gly Ala Ser Pro Arg Arg Gly Glu Leu Arg Arg Gly Ser Ser Ala
                2005                2010                2015    
Glu Ser Ala Leu Pro Arg Ala Gly Pro Arg Glu Leu Gly Arg Gly Leu
            2020                2025                2030        
His Lys Ala Ala Ser Val Glu Leu Pro Gln Arg Arg Ser Pro Ser Pro
        2035                2040                2045            
Gly Ala Thr Arg Leu Ala Arg Gly Gly Leu Gly Glu Gly Glu Tyr Ala
    2050                2055                2060                
Gln Arg Leu Gln Ala Leu Arg Gln Arg Leu Leu Arg Gly Gly Pro Glu
2065                2070                2075               2080 
Asp Gly Lys Val Ser Gly Leu Arg Gly Pro Leu Leu Glu Ser Leu Gly
                2085                2090                2095    
Gly Arg Ala Arg Asp Pro Arg Met Ala Arg Ala Ala Ser Ser Glu Ala
            2100                2105                2110        
Ala Pro His His Gln Pro Pro Leu Glu Asn Arg Gly Leu Gln Lys Ser
        2115                2120                2125            
Ser Ser Phe Ser Gln Gly Glu Ala Glu Pro Arg Gly Arg His Arg Arg
    2130                2135                2140                
Ala Gly Ala Pro Leu Glu Ile Pro Val Ala Arg Leu Gly Ala Arg Arg
2145                2150                2155               2160 
Leu Gln Glu Ser Pro Ser Leu Ser Ala Leu Ser Glu Ala Gln Pro Ser
                2165                2170                2175    
Ser Pro Ala Arg Pro Ser Ala Pro Lys Pro Ser Thr Pro Lys Ser Ala
            2180                2185                2190        
Glu Pro Ser Ala Thr Thr Pro Ser Asp Ala Pro Gln Pro Pro Ala Pro
        2195                2200                2205            
Gln Pro Ala Gln Asp Lys Ala Pro Glu Pro Arg Pro Glu Pro Val Arg
    2210                2215                2220                
Ala Ser Lys Pro Ala Pro Pro Pro Gln Ala Leu Gln Thr Leu Ala Leu
2225                2230                2235               2240 
Pro Leu Thr Pro Tyr Ala Gln Ile Ile Gln Ser Leu Gln Leu Ser Gly
                2245                2250                2255    
His Ala Gln Gly Pro Ser Gln Gly Pro Ala Ala Pro Pro Ser Glu Pro
            2260                2265                2270        
Lys Pro His Ala Ala Val Phe Ala Arg Val Ala Ser Pro Pro Pro Gly
        2275                2280                2285            
Ala Pro Glu Lys Arg Val Pro Ser Ala Gly Gly Pro Pro Val Leu Ala
    2290                2295                2300                
Glu Lys Ala Arg Val Pro Thr Val Pro Pro Arg Pro Gly Ser Ser Leu
2305                2310                2315               2320 
Ser Ser Ser Ile Glu Asn Leu Glu Ser Glu Ala Val Phe Glu Ala Lys
                2325                2330                2335    
Phe Lys Arg Ser Arg Glu Ser Pro Leu Ser Leu Gly Leu Arg Leu Leu
            2340                2345                2350        
Ser Arg Ser Arg Ser Glu Glu Arg Gly Pro Phe Arg Gly Ala Glu Glu
        2355                2360                2365            
Glu Asp Gly Ile Tyr Arg Pro Ser Pro Ala Gly Thr Pro Leu Glu Leu
    2370                2375                2380                
Val Arg Arg Pro Glu Arg Ser Arg Ser Val Gln Asp Leu Arg Ala Val
2385                2390                2395               2400 
Gly Glu Pro Gly Leu Val Arg Arg Leu Ser Leu Ser Leu Ser Gln Arg
                2405                2410                2415    
Leu Arg Arg Thr Pro Pro Ala Gln Arg His Pro Ala Trp Glu Ala Arg
            2420                2425                2430        
Gly Gly Asp Gly Glu Ser Ser Glu Gly Gly Ser Ser Ala Arg Gly Ser
        2435                2440                2445            
Pro Val Leu Ala Met Arg Arg Arg Leu Ser Phe Thr Leu Glu Arg Leu
    2450                2455                2460                
Ser Ser Arg Leu Gln Arg Ser Gly Ser Ser Glu Asp Ser Gly Gly Ala
2465                2470                2475               2480 
Ser Gly Arg Ser Thr Pro Leu Phe Gly Arg Leu Arg Arg Ala Thr Ser
                2485                2490                2495    
Glu Gly Glu Ser Leu Arg Arg Leu Gly Leu Pro His Asn Gln Leu Ala
            2500                2505                2510        
Ala Gln Ala Gly Ala Thr Thr Pro Ser Ala Glu Ser Leu Gly Ser Glu
        2515                2520                2525            
Ala Ser Ala Thr Ser Gly Ser Ser Ala Pro Gly Glu Ser Arg Ser Arg
    2530                2535                2540                
Leu Arg Trp Gly Phe Ser Arg Pro Arg Lys Asp Lys Gly Leu Ser Pro
2545                2550                2555               2560 
Pro Asn Leu Ser Ala Ser Val Gln Glu Glu Leu Gly His Gln Tyr Val
                2565                2570                2575    
Arg Ser Glu Ser Asp Phe Pro Pro Val Phe His Ile Lys Leu Lys Asp
            2580                2585                2590        
Gln Val Leu Leu Glu Gly Glu Ala Ala Thr Leu Leu Cys Leu Pro Ala
        2595                2600                2605            
Ala Cys Pro Ala Pro His Ile Ser Trp Met Lys Asp Lys Lys Ser Leu
    2610                2615                2620                
Arg Ser Glu Pro Ser Val Ile Ile Val Ser Cys Lys Asp Gly Arg Gln
2625                2630                2635               2640 
Leu Leu Ser Ile Pro Arg Ala Gly Lys Arg His Ala Gly Leu Tyr Glu
                2645                2650                2655    
Cys Ser Ala Thr Asn Val Leu Gly Ser Ile Thr Ser Ser Cys Thr Val
            2660                2665                2670        
Ala Val Ala Arg Val Pro Gly Lys Leu Ala Pro Pro Glu Val Pro Gln
        2675                2680                2685            
Thr Tyr Gln Asp Thr Ala Leu Val Leu Trp Lys Pro Gly Asp Ser Arg
    2690                2695                2700                
Ala Pro Cys Thr Tyr Thr Leu Glu Arg Arg Val Asp Gly Glu Ser Val
2705                2710                2715               2720 
Trp His Pro Val Ser Ser Gly Ile Pro Asp Cys Tyr Tyr Asn Val Thr
                2725                2730                2735    
His Leu Pro Val Gly Val Thr Val Arg Phe Arg Val Ala Cys Ala Asn
            2740                2745                2750        
Arg Ala Gly Gln Gly Pro Phe Ser Asn Ser Ser Glu Lys Val Phe Val
        2755                2760                2765            
Arg Gly Thr Gln Asp Ser Ser Ala Val Pro Ser Ala Ala His Gln Glu
    2770                2775                2780                
Ala Pro Val Thr Ser Arg Pro Ala Arg Ala Arg Pro Pro Asp Ser Pro
2785                2790                2795               2800 
Thr Ser Leu Ala Pro Pro Leu Ala Pro Ala Ala Pro Thr Pro Pro Ser
                2805                2810                2815    
Val Thr Val Ser Pro Ser Ser Pro Pro Thr Pro Pro Ser Gln Ala Leu
            2820                2825                2830        
Ser Ser Leu Lys Ala Val Gly Pro Pro Pro Gln Thr Pro Pro Arg Arg
        2835                2840                2845            
His Arg Gly Leu Gln Ala Ala Arg Pro Ala Glu Pro Thr Leu Pro Ser
    2850                2855                2860                
Thr His Val Thr Pro Ser Glu Pro Lys Pro Phe Val Leu Asp Thr Gly
2865                2870                2875               2880 
Thr Pro Ile Pro Ala Ser Thr Pro Gln Gly Val Lys Pro Val Ser Ser
                2885                2890                2895    
Ser Thr Pro Val Tyr Val Val Thr Ser Phe Val Ser Ala Pro Pro Ala
            2900                2905                2910        
Pro Glu Pro Pro Ala Pro Glu Pro Pro Pro Glu Pro Thr Lys Val Thr
        2915                2920                2925            
Val Gln Ser Leu Ser Pro Ala Lys Glu Val Val Ser Ser Pro Gly Ser
    2930                2935                2940                
Ser Pro Arg Ser Ser Pro Arg Pro Glu Gly Thr Thr Leu Arg Gln Gly
2945                2950                2955               2960 
Pro Pro Gln Lys Pro Tyr Thr Phe Leu Glu Glu Lys Ala Arg Gly Arg
                2965                2970                2975    
Phe Gly Val Val Arg Ala Cys Arg Glu Asn Ala Thr Gly Arg Thr Phe
            2980                2985                2990        
Val Ala Lys Ile Val Pro Tyr Ala Ala Glu Gly Lys Arg Arg Val Leu
        2995                3000                3005            
Gln Glu Tyr Glu Val Leu Arg Thr Leu His His Glu Arg Ile Met Ser
    3010                3015                3020                
Leu His Glu Ala Tyr Ile Thr Pro Arg Tyr Leu Val Leu Ile Ala Glu
3025                3030                3035               3040 
Ser Cys Gly Asn Arg Glu Leu Leu Cys Gly Leu Ser Asp Arg Phe Arg
                3045                3050                3055    
Tyr Ser Glu Asp Asp Val Ala Thr Tyr Met Val Gln Leu Leu Gln Gly
            3060                3065                3070        
Leu Asp Tyr Leu His Gly His His Val Leu His Leu Asp Ile Lys Pro
        3075                3080                3085            
Asp Asn Leu Leu Leu Ala Pro Asp Asn Ala Leu Lys Ile Val Asp Phe
    3090                3095                3100                
Gly Ser Ala Gln Pro Tyr Asn Pro Gln Ala Leu Arg Pro Leu Gly His
3105                3110                3115               3120 
Arg Thr Gly Thr Leu Glu Phe Met Ala Pro Glu Met Val Lys Gly Glu
                3125                3130                3135    
Pro Ile Gly Ser Ala Thr Asp Ile Trp Gly Ala Gly Val Leu Thr Tyr
            3140                3145                3150        
Ile Met Leu Ser Gly Arg Ser Pro Phe Tyr Glu Pro Asp Pro Gln Glu
        3155                3160                3165            
Thr Glu Ala Arg Ile Val Gly Gly Arg Phe Asp Ala Phe Gln Leu Tyr
    3170                3175                3180                
Pro Asn Thr Ser Gln Ser Ala Thr Leu Phe Leu Arg Lys Val Leu Ser
3185                3190                3195               3200 
Val His Pro Trp Ser Arg Pro Ser Leu Gln Asp Cys Leu Ala His Pro
                3205                3210                3215    
Trp Leu Gln Asp Ala Tyr Leu Met Lys Leu Arg Arg Gln Thr Leu Thr
            3220                3225                3230        
Phe Thr Thr Asn Arg Leu Lys Glu Phe Leu Gly Glu Gln Arg Arg Arg
        3235                3240                3245            
Arg Ala Glu Ala Ala Thr Arg His Lys Val Leu Leu Arg Ser Tyr Pro
    3250                3255                3260                
Gly Gly Pro
3265        


<210> 93
<211> 393
<212> PRT
<213> Homo sapiens

<400> 93
Met Pro Lys Lys Lys Pro Thr Pro Ile Gln Leu Asn Pro Ala Pro Asp
 1               5                  10                  15      
Gly Ser Ala Val Asn Gly Thr Ser Ser Ala Glu Thr Asn Leu Glu Ala
            20                  25                  30          
Leu Gln Lys Lys Leu Glu Glu Leu Glu Leu Asp Glu Gln Gln Arg Lys
        35                  40                  45              
Arg Leu Glu Ala Phe Leu Thr Gln Lys Gln Lys Val Gly Glu Leu Lys
    50                  55                  60                  
Asp Asp Asp Phe Glu Lys Ile Ser Glu Leu Gly Ala Gly Asn Gly Gly
65                  70                  75                  80  
Val Val Phe Lys Val Ser His Lys Pro Ser Gly Leu Val Met Ala Arg
                85                  90                  95      
Lys Leu Ile His Leu Glu Ile Lys Pro Ala Ile Arg Asn Gln Ile Ile
            100                 105                 110         
Arg Glu Leu Gln Val Leu His Glu Cys Asn Ser Pro Tyr Ile Val Gly
        115                 120                 125             
Phe Tyr Gly Ala Phe Tyr Ser Asp Gly Glu Ile Ser Ile Cys Met Glu
    130                 135                 140                 
His Met Asp Gly Gly Ser Leu Asp Gln Val Leu Lys Lys Ala Gly Arg
145                 150                 155                 160 
Ile Pro Glu Gln Ile Leu Gly Lys Val Ser Ile Ala Val Ile Lys Gly
                165                 170                 175     
Leu Thr Tyr Leu Arg Glu Lys His Lys Ile Met His Arg Asp Val Lys
            180                 185                 190         
Pro Ser Asn Ile Leu Val Asn Ser Arg Gly Glu Ile Lys Leu Cys Asp
        195                 200                 205             
Phe Gly Val Ser Gly Gln Leu Ile Asp Ser Met Ala Asn Ser Phe Val
    210                 215                 220                 
Gly Thr Arg Ser Tyr Met Ser Pro Glu Arg Leu Gln Gly Thr His Tyr
225                 230                 235                 240 
Ser Val Gln Ser Asp Ile Trp Ser Met Gly Leu Ser Leu Val Glu Met
                245                 250                 255     
Ala Val Gly Arg Tyr Pro Ile Pro Pro Pro Asp Ala Lys Glu Leu Glu
            260                 265                 270         
Leu Met Phe Gly Cys Gln Val Glu Gly Asp Ala Ala Glu Thr Pro Pro
        275                 280                 285             
Arg Pro Arg Thr Pro Gly Arg Pro Leu Ser Ser Tyr Gly Met Asp Ser
    290                 295                 300                 
Arg Pro Pro Met Ala Ile Phe Glu Leu Leu Asp Tyr Ile Val Asn Glu
305                 310                 315                 320 
Pro Pro Pro Lys Leu Pro Ser Gly Val Phe Ser Leu Glu Phe Gln Asp
                325                 330                 335     
Phe Val Asn Lys Cys Leu Ile Lys Asn Pro Ala Glu Arg Ala Asp Leu
            340                 345                 350         
Lys Gln Leu Met Val His Ala Phe Ile Lys Arg Ser Asp Ala Glu Glu
        355                 360                 365             
Val Asp Phe Ala Gly Trp Leu Cys Ser Thr Ile Gly Leu Asn Gln Pro
    370                 375                 380                 
Ser Thr Pro Thr His Ala Ala Gly Val
385                 390             


<210> 94
<211> 673
<212> PRT
<213> Homo sapiens

<400> 94
Met Ala Asp Pro Ala Ala Gly Pro Pro Pro Ser Glu Gly Glu Glu Ser
 1               5                  10                  15      
Thr Val Arg Phe Ala Arg Lys Gly Ala Leu Arg Gln Lys Asn Val His
            20                  25                  30          
Glu Val Lys Asn His Lys Phe Thr Ala Arg Phe Phe Lys Gln Pro Thr
        35                  40                  45              
Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys Gln Gly
    50                  55                  60                  
Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys His Glu
65                  70                  75                  80  
Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Ala Ser Asp
                85                  90                  95      
Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Ser Ser Pro
            100                 105                 110         
Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile His Gln
        115                 120                 125             
Gly Met Lys Cys Asp Thr Cys Met Met Asn Val His Lys Arg Cys Val
    130                 135                 140                 
Met Asn Val Pro Ser Leu Cys Gly Thr Asp His Thr Glu Arg Arg Gly
145                 150                 155                 160 
Arg Ile Tyr Ile Gln Ala His Ile Asp Arg Asp Val Leu Ile Val Leu
                165                 170                 175     
Val Arg Asp Ala Lys Asn Leu Val Pro Met Asp Pro Asn Gly Leu Ser
            180                 185                 190         
Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Ser Glu Ser
        195                 200                 205             
Lys Gln Lys Thr Lys Thr Ile Lys Cys Ser Leu Asn Pro Glu Trp Asn
    210                 215                 220                 
Glu Thr Phe Arg Phe Gln Leu Lys Glu Ser Asp Lys Asp Arg Arg Leu
225                 230                 235                 240 
Ser Val Glu Ile Trp Asp Trp Asp Leu Thr Ser Arg Asn Asp Phe Met
                245                 250                 255     
Gly Ser Leu Ser Phe Gly Ile Ser Glu Leu Gln Lys Ala Ser Val Asp
            260                 265                 270         
Gly Trp Phe Lys Leu Leu Ser Gln Glu Glu Gly Glu Tyr Phe Asn Val
        275                 280                 285             
Pro Val Pro Pro Glu Gly Ser Glu Ala Asn Glu Glu Leu Arg Gln Lys
    290                 295                 300                 
Phe Glu Arg Ala Lys Ile Ser Gln Gly Thr Lys Val Pro Glu Glu Lys
305                 310                 315                 320 
Thr Thr Asn Thr Val Ser Lys Phe Asp Asn Asn Gly Asn Arg Asp Arg
                325                 330                 335     
Met Lys Leu Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys Gly Ser
            340                 345                 350         
Phe Gly Lys Val Met Leu Ser Glu Arg Lys Gly Thr Asp Glu Leu Tyr
        355                 360                 365             
Ala Val Lys Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp Asp Val
    370                 375                 380                 
Glu Cys Thr Met Val Glu Lys Arg Val Leu Ala Leu Pro Gly Lys Pro
385                 390                 395                 400 
Pro Phe Leu Thr Gln Leu His Ser Cys Phe Gln Thr Met Asp Arg Leu
                405                 410                 415     
Tyr Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Tyr His Ile
            420                 425                 430         
Gln Gln Val Gly Arg Phe Lys Glu Pro His Ala Val Phe Tyr Ala Ala
        435                 440                 445             
Glu Ile Ala Ile Gly Leu Phe Phe Leu Gln Ser Lys Gly Ile Ile Tyr
    450                 455                 460                 
Arg Asp Leu Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly His Ile
465                 470                 475                 480 
Lys Ile Ala Asp Phe Gly Met Cys Lys Glu Asn Ile Trp Asp Gly Val
                485                 490                 495     
Thr Thr Lys Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile
            500                 505                 510         
Ile Ala Tyr Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala Phe Gly
        515                 520                 525             
Val Leu Leu Tyr Glu Met Leu Ala Gly Gln Ala Pro Phe Glu Gly Glu
    530                 535                 540                 
Asp Glu Asp Glu Leu Phe Gln Ser Ile Met Glu His Asn Val Ala Tyr
545                 550                 555                 560 
Pro Lys Ser Met Ser Lys Glu Ala Val Ala Ile Cys Lys Gly Leu Met
                565                 570                 575     
Thr Lys His Pro Gly Lys Arg Leu Gly Cys Gly Pro Glu Gly Glu Arg
            580                 585                 590         
Asp Ile Lys Glu His Ala Phe Phe Arg Tyr Ile Asp Trp Glu Lys Leu
        595                 600                 605             
Glu Arg Lys Glu Ile Gln Pro Pro Tyr Lys Pro Lys Ala Cys Gly Arg
    610                 615                 620                 
Asn Ala Glu Asn Phe Asp Arg Phe Phe Thr Arg His Pro Pro Val Leu
625                 630                 635                 640 
Thr Pro Pro Asp Gln Glu Val Ile Arg Asn Ile Asp Gln Ser Glu Phe
                645                 650                 655     
Glu Gly Phe Ser Phe Val Asn Ser Glu Phe Leu Lys Pro Glu Val Lys
            660                 665                 670         
Ser
    


<210> 95
<211> 726
<212> PRT
<213> Homo sapiens

<400> 95
Met Ser Glu Glu Thr Val Pro Glu Ala Ala Ser Pro Pro Pro Pro Gln
 1               5                  10                  15      
Gly Gln Pro Tyr Phe Asp Arg Phe Ser Glu Asp Asp Pro Glu Tyr Met
            20                  25                  30          
Arg Leu Arg Asn Arg Ala Ala Asp Leu Arg Gln Asp Phe Asn Leu Met
        35                  40                  45              
Glu Gln Lys Lys Arg Val Thr Met Ile Leu Gln Ser Pro Ser Phe Arg
    50                  55                  60                  
Glu Glu Leu Glu Gly Leu Ile Gln Glu Gln Met Lys Lys Gly Asn Asn
65                  70                  75                  80  
Ser Ser Asn Ile Trp Ala Leu Arg Gln Ile Ala Asp Phe Met Ala Ser
                85                  90                  95      
Thr Ser His Ala Val Phe Pro Thr Ser Ser Met Asn Val Ser Met Met
            100                 105                 110         
Thr Pro Ile Asn Asp Leu His Thr Ala Asp Ser Leu Asn Leu Ala Lys
        115                 120                 125             
Gly Glu Arg Leu Met Arg Cys Lys Ile Ser Ser Val Tyr Arg Leu Leu
    130                 135                 140                 
Asp Leu Tyr Gly Trp Ala Gln Leu Ser Asp Thr Tyr Val Thr Leu Arg
145                 150                 155                 160 
Val Ser Lys Glu Gln Asp His Phe Leu Ile Ser Pro Lys Gly Val Ser
                165                 170                 175     
Cys Ser Glu Val Thr Ala Ser Ser Leu Ile Lys Val Asn Ile Leu Gly
            180                 185                 190         
Glu Val Val Glu Lys Gly Ser Ser Cys Phe Pro Val Asp Thr Thr Gly
        195                 200                 205             
Phe Cys Leu His Ser Ala Ile Tyr Ala Ala Arg Pro Asp Val Arg Cys
    210                 215                 220                 
Ile Ile His Leu His Thr Pro Ala Thr Ala Ala Val Ser Ala Met Lys
225                 230                 235                 240 
Trp Gly Leu Leu Pro Val Ser His Asn Ala Leu Leu Val Gly Asp Met
                245                 250                 255     
Ala Tyr Tyr Asp Phe Asn Gly Glu Met Glu Gln Glu Ala Asp Arg Ile
            260                 265                 270         
Asn Leu Gln Lys Cys Leu Gly Pro Thr Cys Lys Ile Leu Val Leu Arg
        275                 280                 285             
Asn His Gly Val Val Ala Leu Gly Asp Thr Val Glu Glu Ala Phe Tyr
    290                 295                 300                 
Lys Ile Phe His Leu Gln Ala Ala Cys Glu Ile Gln Val Ser Ala Leu
305                 310                 315                 320 
Ser Ser Ala Gly Gly Val Glu Asn Leu Ile Leu Leu Glu Gln Glu Lys
                325                 330                 335     
His Arg Pro His Glu Val Gly Ser Val Gln Trp Ala Gly Ser Thr Phe
            340                 345                 350         
Gly Pro Met Gln Lys Ser Arg Leu Gly Glu His Glu Phe Glu Ala Leu
        355                 360                 365             
Met Arg Met Leu Asp Asn Leu Gly Tyr Arg Thr Gly Tyr Thr Tyr Arg
    370                 375                 380                 
His Pro Phe Val Gln Glu Lys Thr Lys His Lys Ser Glu Val Glu Ile
385                 390                 395                 400 
Pro Ala Thr Val Thr Ala Phe Val Phe Glu Glu Asp Gly Ala Pro Val
                405                 410                 415     
Pro Ala Leu Arg Gln His Ala Gln Lys Gln Gln Lys Glu Lys Thr Arg
            420                 425                 430         
Trp Leu Asn Thr Pro Asn Ala Tyr Leu Arg Val Asn Val Ala Asp Glu
        435                 440                 445             
Val Gln Arg Ser Met Gly Ser Pro Arg Pro Lys Thr Thr Trp Met Lys
    450                 455                 460                 
Ala Asp Glu Val Glu Lys Ser Ser Ser Gly Met Pro Ile Arg Ile Glu
465                 470                 475                 480 
Asn Pro Asn Gln Phe Val Pro Leu Tyr Thr Asp Pro Gln Glu Val Leu
                485                 490                 495     
Glu Met Arg Asn Lys Ile Arg Glu Gln Asn Arg Gln Asp Val Lys Ser
            500                 505                 510         
Ala Gly Pro Gln Ser Gln Leu Leu Ala Ser Val Ile Ala Glu Lys Ser
        515                 520                 525             
Arg Ser Pro Ser Thr Glu Ser Gln Leu Met Ser Lys Gly Asp Glu Asp
    530                 535                 540                 
Thr Lys Asp Asp Ser Glu Glu Thr Val Pro Asn Pro Phe Ser Gln Leu
545                 550                 555                 560 
Thr Asp Gln Glu Leu Glu Glu Tyr Lys Lys Glu Val Glu Arg Lys Lys
                565                 570                 575     
Leu Glu Leu Asp Gly Glu Lys Glu Thr Ala Pro Glu Glu Pro Gly Ser
            580                 585                 590         
Pro Ala Lys Ser Ala Pro Ala Ser Pro Val Gln Ser Pro Ala Lys Glu
        595                 600                 605             
Ala Glu Thr Lys Ser Pro Leu Val Ser Pro Ser Lys Ser Leu Glu Glu
    610                 615                 620                 
Gly Thr Lys Lys Thr Glu Thr Ser Lys Ala Ala Thr Thr Glu Pro Glu
625                 630                 635                 640 
Thr Thr Gln Pro Glu Gly Val Val Val Asn Gly Arg Glu Glu Glu Gln
                645                 650                 655     
Thr Ala Glu Glu Ile Leu Ser Lys Gly Leu Ser Gln Met Thr Thr Ser
            660                 665                 670         
Ala Asp Thr Asp Val Asp Thr Ser Lys Asp Lys Thr Glu Ser Val Thr
        675                 680                 685             
Ser Gly Pro Met Ser Pro Glu Gly Ser Pro Ser Lys Ser Pro Ser Lys
    690                 695                 700                 
Lys Lys Lys Lys Phe Arg Thr Pro Ser Phe Leu Lys Lys Ser Lys Lys
705                 710                 715                 720 
Lys Glu Lys Val Glu Ser
                725     


<210> 96
<211> 603
<212> PRT
<213> Homo sapiens

<400> 96
Met Ser Ala Ala Val Thr Ala Gly Lys Leu Ala Arg Ala Pro Ala Asp
 1               5                  10                  15      
Pro Gly Lys Ala Gly Val Pro Gly Val Ala Ala Pro Gly Ala Pro Ala
            20                  25                  30          
Ala Ala Pro Pro Ala Lys Glu Ile Pro Glu Val Leu Val Asp Pro Arg
        35                  40                  45              
Ser Arg Arg Arg Tyr Val Arg Gly Arg Phe Leu Gly Lys Gly Gly Phe
    50                  55                  60                  
Ala Lys Cys Phe Glu Ile Ser Asp Ala Asp Thr Lys Glu Val Phe Ala
65                  70                  75                  80  
Gly Lys Ile Val Pro Lys Ser Leu Leu Leu Lys Pro His Gln Arg Glu
                85                  90                  95      
Lys Met Ser Met Glu Ile Ser Ile His Arg Ser Leu Ala His Gln His
            100                 105                 110         
Val Val Gly Phe His Gly Phe Phe Glu Asp Asn Asp Phe Val Phe Val
        115                 120                 125             
Val Leu Glu Leu Cys Arg Arg Arg Ser Leu Leu Glu Leu His Lys Arg
    130                 135                 140                 
Arg Lys Ala Leu Thr Glu Pro Glu Ala Arg Tyr Tyr Leu Arg Gln Ile
145                 150                 155                 160 
Val Leu Gly Cys Gln Tyr Leu His Arg Asn Arg Val Ile His Arg Asp
                165                 170                 175     
Leu Lys Leu Gly Asn Leu Phe Leu Asn Glu Asp Leu Glu Val Lys Ile
            180                 185                 190         
Gly Asp Phe Gly Leu Ala Thr Lys Val Glu Tyr Asp Gly Glu Arg Lys
        195                 200                 205             
Lys Thr Leu Cys Gly Thr Pro Asn Tyr Ile Ala Pro Glu Val Leu Ser
    210                 215                 220                 
Lys Lys Gly His Ser Phe Glu Val Asp Val Trp Ser Ile Gly Cys Ile
225                 230                 235                 240 
Met Tyr Thr Leu Leu Val Gly Lys Pro Pro Phe Glu Thr Ser Cys Leu
                245                 250                 255     
Lys Glu Thr Tyr Leu Arg Ile Lys Lys Asn Glu Tyr Ser Ile Pro Lys
            260                 265                 270         
His Ile Asn Pro Val Ala Ala Ser Leu Ile Gln Lys Met Leu Gln Thr
        275                 280                 285             
Asp Pro Thr Ala Arg Pro Thr Ile Asn Glu Leu Leu Asn Asp Glu Phe
    290                 295                 300                 
Phe Thr Ser Gly Tyr Ile Pro Ala Arg Leu Pro Ile Thr Cys Leu Thr
305                 310                 315                 320 
Ile Pro Pro Arg Phe Ser Ile Ala Pro Ser Ser Leu Asp Pro Ser Asn
                325                 330                 335     
Arg Lys Pro Leu Thr Val Leu Asn Lys Gly Leu Glu Asn Pro Leu Pro
            340                 345                 350         
Glu Arg Pro Arg Glu Lys Glu Glu Pro Val Val Arg Glu Thr Gly Glu
        355                 360                 365             
Val Val Asp Cys His Leu Ser Asp Met Leu Gln Gln Leu His Ser Val
    370                 375                 380                 
Asn Ala Ser Lys Pro Ser Glu Arg Gly Leu Val Arg Gln Glu Glu Ala
385                 390                 395                 400 
Glu Asp Pro Ala Cys Ile Pro Ile Phe Trp Val Ser Lys Trp Val Asp
                405                 410                 415     
Tyr Ser Asp Lys Tyr Gly Leu Gly Tyr Gln Leu Cys Asp Asn Ser Val
            420                 425                 430         
Gly Val Leu Phe Asn Asp Ser Thr Arg Leu Ile Leu Tyr Asn Asp Gly
        435                 440                 445             
Asp Ser Leu Gln Tyr Ile Glu Arg Asp Gly Thr Glu Ser Tyr Leu Thr
    450                 455                 460                 
Val Ser Ser His Pro Asn Ser Leu Met Lys Lys Ile Thr Leu Leu Lys
465                 470                 475                 480 
Tyr Phe Arg Asn Tyr Met Ser Glu His Leu Leu Lys Ala Gly Ala Asn
                485                 490                 495     
Ile Thr Pro Arg Glu Gly Asp Glu Leu Ala Arg Leu Pro Tyr Leu Arg
            500                 505                 510         
Thr Trp Phe Arg Thr Arg Ser Ala Ile Ile Leu His Leu Ser Asn Gly
        515                 520                 525             
Ser Val Gln Ile Asn Phe Phe Gln Asp His Thr Lys Leu Ile Leu Cys
    530                 535                 540                 
Pro Leu Met Ala Ala Val Thr Tyr Ile Asp Glu Lys Arg Asp Phe Arg
545                 550                 555                 560 
Thr Tyr Arg Leu Ser Leu Leu Glu Glu Tyr Gly Cys Cys Lys Glu Leu
                565                 570                 575     
Ala Ser Arg Leu Arg Tyr Ala Arg Thr Met Val Asp Lys Leu Leu Ser
            580                 585                 590         
Ser Arg Ser Ala Ser Asn Arg Leu Lys Ala Ser
        595                 600             


<210> 97
<211> 556
<212> PRT
<213> Homo sapiens

<400> 97
Met Ala Arg Thr Thr Ser Gln Leu Tyr Asp Ala Val Pro Ile Gln Ser
 1               5                  10                  15      
Ser Val Val Leu Cys Ser Cys Pro Ser Pro Ser Met Val Arg Thr Gln
            20                  25                  30          
Thr Glu Ser Ser Thr Pro Pro Gly Ile Pro Gly Gly Ser Arg Gln Gly
        35                  40                  45              
Pro Ala Met Asp Gly Thr Ala Ala Glu Pro Arg Pro Gly Ala Gly Ser
    50                  55                  60                  
Leu Gln His Ala Gln Pro Pro Pro Gln Pro Arg Lys Lys Arg Pro Glu
65                  70                  75                  80  
Asp Phe Lys Phe Gly Lys Ile Leu Gly Glu Gly Ser Phe Ser Thr Val
                85                  90                  95      
Val Leu Ala Arg Glu Leu Ala Thr Ser Arg Glu Tyr Ala Ile Lys Ile
            100                 105                 110         
Leu Glu Lys Arg His Ile Ile Lys Glu Asn Lys Val Pro Tyr Val Thr
        115                 120                 125             
Arg Glu Arg Asp Val Met Ser Arg Leu Asp His Pro Phe Phe Val Lys
    130                 135                 140                 
Leu Tyr Phe Thr Phe Gln Asp Asp Glu Lys Leu Tyr Phe Gly Leu Ser
145                 150                 155                 160 
Tyr Ala Lys Asn Gly Glu Leu Leu Lys Tyr Ile Arg Lys Ile Gly Ser
                165                 170                 175     
Phe Asp Glu Thr Cys Thr Arg Phe Tyr Thr Ala Glu Ile Val Ser Ala
            180                 185                 190         
Leu Glu Tyr Leu His Gly Lys Gly Ile Ile His Arg Asp Leu Lys Pro
        195                 200                 205             
Glu Asn Ile Leu Leu Asn Glu Asp Met His Ile Gln Ile Thr Asp Phe
    210                 215                 220                 
Gly Thr Ala Lys Val Leu Ser Pro Glu Ser Lys Gln Ala Arg Ala Asn
225                 230                 235                 240 
Ser Phe Val Gly Thr Ala Gln Tyr Val Ser Pro Glu Leu Leu Thr Glu
                245                 250                 255     
Lys Ser Ala Cys Lys Ser Ser Asp Leu Trp Ala Leu Gly Cys Ile Ile
            260                 265                 270         
Tyr Gln Leu Val Ala Gly Leu Pro Pro Phe Arg Ala Gly Asn Glu Tyr
        275                 280                 285             
Leu Ile Phe Gln Lys Ile Ile Lys Leu Glu Tyr Asp Phe Pro Glu Lys
    290                 295                 300                 
Phe Phe Pro Lys Ala Arg Asp Leu Val Glu Lys Leu Leu Val Leu Asp
305                 310                 315                 320 
Ala Thr Lys Arg Leu Gly Cys Glu Glu Met Glu Gly Tyr Gly Pro Leu
                325                 330                 335     
Lys Ala His Pro Phe Phe Glu Ser Val Thr Trp Glu Asn Leu His Gln
            340                 345                 350         
Gln Thr Pro Pro Lys Leu Thr Ala Tyr Leu Pro Ala Met Ser Glu Asp
        355                 360                 365             
Asp Glu Asp Cys Tyr Gly Asn Tyr Asp Asn Leu Leu Ser Gln Phe Gly
    370                 375                 380                 
Cys Met Gln Val Ser Ser Ser Ser Ser Ser His Ser Leu Ser Ala Ser
385                 390                 395                 400 
Asp Thr Gly Leu Pro Gln Arg Ser Gly Ser Asn Ile Glu Gln Tyr Ile
                405                 410                 415     
His Asp Leu Asp Ser Asn Ser Phe Glu Leu Asp Leu Gln Phe Ser Glu
            420                 425                 430         
Asp Glu Lys Arg Leu Leu Leu Glu Lys Gln Ala Gly Gly Asn Pro Trp
        435                 440                 445             
His Gln Phe Val Glu Asn Asn Leu Ile Leu Lys Met Gly Pro Val Asp
    450                 455                 460                 
Lys Arg Lys Gly Leu Phe Ala Arg Arg Arg Gln Leu Leu Leu Thr Glu
465                 470                 475                 480 
Gly Pro His Leu Tyr Tyr Val Asp Pro Val Asn Lys Val Leu Lys Gly
                485                 490                 495     
Glu Ile Pro Trp Ser Gln Glu Leu Arg Pro Glu Ala Lys Asn Phe Lys
            500                 505                 510         
Thr Phe Phe Val His Thr Pro Asn Arg Thr Tyr Tyr Leu Met Asp Pro
        515                 520                 525             
Ser Gly Asn Ala His Lys Trp Cys Arg Lys Ile Gln Glu Val Trp Arg
    530                 535                 540                 
Gln Arg Tyr Gln Ser His Pro Asp Ala Ala Val Gln
545                 550                 555     


<210> 98
<211> 506
<212> PRT
<213> Homo sapiens

<400> 98
Met Asp Asp Tyr Met Val Leu Arg Met Ile Gly Glu Gly Ser Phe Gly
 1               5                  10                  15      
Arg Ala Leu Leu Val Gln His Glu Ser Ser Asn Gln Met Phe Ala Met
            20                  25                  30          
Lys Glu Ile Arg Leu Pro Lys Ser Phe Ser Asn Thr Gln Asn Ser Arg
        35                  40                  45              
Lys Glu Ala Val Leu Leu Ala Lys Met Lys His Pro Asn Ile Val Ala
    50                  55                  60                  
Phe Lys Glu Ser Phe Glu Ala Glu Gly His Leu Tyr Ile Val Met Glu
65                  70                  75                  80  
Tyr Cys Asp Gly Gly Asp Leu Met Gln Lys Ile Lys Gln Gln Lys Gly
                85                  90                  95      
Lys Leu Phe Pro Glu Asp Met Ile Leu Asn Trp Phe Thr Gln Met Cys
            100                 105                 110         
Leu Gly Val Asn His Ile His Lys Lys Arg Val Leu His Arg Asp Ile
        115                 120                 125             
Lys Ser Lys Asn Ile Phe Leu Thr Gln Asn Gly Lys Val Lys Leu Gly
    130                 135                 140                 
Asp Phe Gly Ser Ala Arg Leu Leu Ser Asn Pro Met Ala Phe Ala Cys
145                 150                 155                 160 
Thr Tyr Val Gly Thr Pro Tyr Tyr Val Pro Pro Glu Ile Trp Glu Asn
                165                 170                 175     
Leu Pro Tyr Asn Asn Lys Ser Asp Ile Trp Ser Leu Gly Cys Ile Leu
            180                 185                 190         
Tyr Glu Leu Cys Thr Leu Lys His Pro Phe Gln Ala Asn Ser Trp Lys
        195                 200                 205             
Asn Leu Ile Leu Lys Val Cys Gln Gly Cys Ile Ser Pro Leu Pro Ser
    210                 215                 220                 
His Tyr Ser Tyr Glu Leu Gln Phe Leu Val Lys Gln Met Phe Lys Arg
225                 230                 235                 240 
Asn Pro Ser His Arg Pro Ser Ala Thr Thr Leu Leu Ser Arg Gly Ile
                245                 250                 255     
Val Ala Arg Leu Val Gln Lys Cys Leu Pro Pro Glu Ile Ile Met Glu
            260                 265                 270         
Tyr Gly Glu Glu Val Leu Glu Glu Ile Lys Asn Ser Lys His Asn Thr
        275                 280                 285             
Pro Arg Lys Lys Thr Asn Pro Ser Arg Ile Arg Ile Ala Leu Gly Asn
    290                 295                 300                 
Glu Ala Ser Thr Val Gln Glu Glu Glu Gln Asp Arg Lys Gly Ser His
305                 310                 315                 320 
Thr Asp Leu Glu Ser Ile Asn Glu Asn Leu Val Glu Ser Ala Leu Arg
                325                 330                 335     
Arg Val Asn Arg Glu Glu Lys Gly Asn Lys Ser Val His Leu Arg Lys
            340                 345                 350         
Ala Ser Ser Pro Asn Leu His Arg Arg Gln Trp Glu Lys Asn Val Pro
        355                 360                 365             
Asn Thr Ala Leu Thr Ala Leu Glu Asn Ala Ser Ile Leu Thr Ser Ser
    370                 375                 380                 
Leu Thr Ala Glu Asp Asp Arg Gly Gly Ser Val Ile Lys Tyr Ser Lys
385                 390                 395                 400 
Asn Thr Thr Arg Lys Gln Trp Leu Lys Glu Thr Pro Asp Thr Leu Leu
                405                 410                 415     
Asn Ile Leu Lys Asn Ala Asp Leu Ser Leu Ala Phe Gln Thr Tyr Thr
            420                 425                 430         
Ile Tyr Arg Pro Gly Ser Glu Gly Phe Leu Lys Gly Pro Leu Ser Glu
        435                 440                 445             
Glu Thr Glu Ala Ser Asp Ser Val Asp Gly Gly His Asp Ser Val Ile
    450                 455                 460                 
Leu Asp Pro Glu Arg Leu Glu Pro Gly Leu Asp Glu Glu Asp Thr Asp
465                 470                 475                 480 
Phe Glu Glu Glu Asp Asp Asn Pro Asp Trp Val Ser Glu Leu Lys Lys
                485                 490                 495     
Arg Ala Gly Trp Gln Gly Leu Cys Asp Arg
            500                 505     


<210> 99
<211> 619
<212> PRT
<213> Homo sapiens

<400> 99
Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser
 1               5                  10                  15      
Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly
            20                  25                  30          
Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu
        35                  40                  45              
Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln
    50                  55                  60                  
Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro
65                  70                  75                  80  
Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys
                85                  90                  95      
Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro
            100                 105                 110         
Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg
        115                 120                 125             
Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser
    130                 135                 140                 
Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg
145                 150                 155                 160 
Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys
                165                 170                 175     
Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg
            180                 185                 190         
Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val
        195                 200                 205             
Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro
    210                 215                 220                 
Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys
225                 230                 235                 240 
Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn
                245                 250                 255     
Ser Ser Ala Ser Asn Ala Ser Gly Ala Ala Ala Pro Thr Leu Pro Ala
            260                 265                 270         
His Pro Ser Thr Leu Thr His Pro Gln Arg Arg Ile Asp Thr Leu Asn
        275                 280                 285             
Ser Asp Gly Tyr Thr Pro Glu Pro Ala Arg Ile Thr Ser Pro Asp Lys
    290                 295                 300                 
Pro Arg Pro Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser
305                 310                 315                 320 
Asp Pro Glu Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn
                325                 330                 335     
Leu Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val
            340                 345                 350         
Arg Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile
        355                 360                 365             
Lys Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met
    370                 375                 380                 
Arg Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg
385                 390                 395                 400 
Leu Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Met Glu Met
                405                 410                 415     
Ala Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu
            420                 425                 430         
Ile Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly
        435                 440                 445             
Met Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala
    450                 455                 460                 
Arg Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe
465                 470                 475                 480 
Gly Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg
                485                 490                 495     
Ser Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn
            500                 505                 510         
Phe Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr
        515                 520                 525             
Met Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys
    530                 535                 540                 
Gly Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys
545                 550                 555                 560 
Pro Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp
                565                 570                 575     
Ile Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg
            580                 585                 590         
Met Arg Ala Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly Pro Pro
        595                 600                 605             
Gly Ser Thr Gln Lys Ala Glu Ala Ala Cys Ala
    610                 615                 


<210> 100
<211> 548
<212> PRT
<213> Homo sapiens

<400> 100
Met Ala Glu Glu Leu Val Leu Glu Arg Cys Asp Leu Glu Leu Glu Thr
 1               5                  10                  15      
Asn Gly Arg Asp His His Thr Ala Asp Leu Cys Arg Glu Lys Leu Val
            20                  25                  30          
Val Arg Arg Gly Gln Pro Phe Trp Leu Thr Leu His Phe Glu Gly Arg
        35                  40                  45              
Asn Tyr Glu Ala Ser Val Asp Ser Leu Thr Phe Ser Val Val Thr Gly
    50                  55                  60                  
Pro Ala Pro Ser Gln Glu Ala Gly Thr Lys Ala Arg Phe Pro Leu Arg
65                  70                  75                  80  
Asp Ala Val Glu Glu Gly Asp Trp Thr Ala Thr Val Val Asp Gln Gln
                85                  90                  95      
Asp Cys Thr Leu Ser Leu Gln Leu Thr Thr Pro Ala Asn Ala Pro Ile
            100                 105                 110         
Gly Leu Tyr Arg Leu Ser Leu Glu Ala Ser Thr Gly Tyr Gln Gly Ser
        115                 120                 125             
Ser Phe Val Leu Gly His Phe Ile Leu Leu Phe Asn Ala Trp Cys Pro
    130                 135                 140                 
Ala Asp Ala Val Tyr Leu Asp Ser Glu Glu Glu Arg Gln Glu Tyr Val
145                 150                 155                 160 
Leu Thr Gln Gln Gly Phe Ile Tyr Gln Gly Ser Ala Lys Phe Ile Lys
                165                 170                 175     
Asn Ile Pro Trp Asn Phe Gly Gln Phe Glu Asp Gly Ile Leu Asp Ile
            180                 185                 190         
Cys Leu Ile Leu Leu Asp Val Asn Pro Lys Phe Leu Lys Asn Ala Gly
        195                 200                 205             
Arg Asp Cys Ser Arg Arg Ser Ser Pro Val Tyr Val Gly Arg Val Val
    210                 215                 220                 
Ser Gly Met Val Asn Cys Asn Asp Asp Gln Gly Val Leu Leu Gly Arg
225                 230                 235                 240 
Trp Asp Asn Asn Tyr Gly Asp Gly Val Ser Pro Met Ser Trp Ile Gly
                245                 250                 255     
Ser Val Asp Ile Leu Arg Arg Trp Lys Asn His Gly Cys Gln Arg Val
            260                 265                 270         
Lys Tyr Gly Gln Cys Trp Val Phe Ala Ala Val Ala Cys Thr Val Leu
        275                 280                 285             
Arg Cys Leu Gly Ile Pro Thr Arg Val Val Thr Asn Tyr Asn Ser Ala
    290                 295                 300                 
His Asp Gln Asn Ser Asn Leu Leu Ile Glu Tyr Phe Arg Asn Glu Phe
305                 310                 315                 320 
Gly Glu Ile Gln Gly Asp Lys Ser Glu Met Ile Trp Asn Phe His Cys
                325                 330                 335     
Trp Val Glu Ser Trp Met Thr Arg Pro Asp Leu Gln Pro Gly Tyr Glu
            340                 345                 350         
Gly Trp Gln Ala Leu Asp Pro Thr Pro Gln Glu Lys Ser Glu Gly Thr
        355                 360                 365             
Tyr Cys Cys Gly Pro Val Pro Val Arg Ala Ile Lys Glu Gly Asp Leu
    370                 375                 380                 
Ser Thr Lys Tyr Asp Ala Pro Phe Val Phe Ala Glu Val Asn Ala Asp
385                 390                 395                 400 
Val Val Asp Trp Ile Gln Gln Asp Asp Gly Ser Val His Lys Ser Ile
                405                 410                 415     
Asn Arg Ser Leu Ile Val Gly Leu Lys Ile Ser Thr Lys Ser Val Gly
            420                 425                 430         
Arg Asp Glu Arg Glu Asp Ile Thr His Thr Tyr Lys Tyr Pro Glu Gly
        435                 440                 445             
Ser Ser Glu Glu Arg Glu Ala Phe Thr Arg Ala Asn His Leu Asn Lys
    450                 455                 460                 
Leu Ala Glu Lys Glu Glu Thr Gly Met Ala Met Arg Ile Arg Val Gly
465                 470                 475                 480 
Gln Ser Met Asn Met Gly Ser Asp Phe Asp Val Phe Ala His Ile Thr
                485                 490                 495     
Asn Asn Thr Ala Glu Glu Tyr Val Cys Arg Leu Leu Leu Cys Ala Arg
            500                 505                 510         
Thr Val Ser Tyr Asn Gly Ile Leu Gly Pro Glu Cys Gly Thr Lys Tyr
        515                 520                 525             
Leu Leu Asn Leu Asn Leu Glu Pro Phe Ser Gly Lys Ala Leu Cys Ser
    530                 535                 540                 
Trp Ser Ile Cys
545             


<210> 101
<211> 576
<212> PRT
<213> Homo sapiens

<400> 101
Met Ala Ala Ser Glu Thr Val Arg Leu Arg Leu Gln Phe Asp Tyr Pro
 1               5                  10                  15      
Pro Pro Ala Thr Pro His Cys Thr Ala Phe Trp Leu Leu Val Asp Leu
            20                  25                  30          
Asn Arg Cys Arg Val Val Thr Asp Leu Ile Ser Leu Ile Arg Gln Arg
        35                  40                  45              
Phe Gly Phe Ser Ser Gly Ala Phe Leu Gly Leu Tyr Leu Glu Gly Gly
    50                  55                  60                  
Leu Leu Pro Pro Ala Glu Ser Ala Arg Leu Val Arg Asp Asn Asp Cys
65                  70                  75                  80  
Leu Arg Val Lys Leu Glu Glu Arg Gly Val Ala Glu Asn Ser Val Val
                85                  90                  95      
Ile Ser Asn Gly Asp Ile Asn Leu Ser Leu Arg Lys Ala Lys Lys Arg
            100                 105                 110         
Ala Phe Gln Leu Glu Glu Gly Glu Glu Thr Glu Pro Asp Cys Lys Tyr
        115                 120                 125             
Ser Lys Lys His Trp Lys Ser Arg Glu Asn Asn Asn Asn Asn Glu Lys
    130                 135                 140                 
Val Leu Asp Leu Glu Pro Lys Ala Val Thr Asp Gln Thr Val Ser Lys
145                 150                 155                 160 
Lys Asn Lys Arg Lys Asn Lys Ala Thr Cys Gly Thr Val Gly Asp Asp
                165                 170                 175     
Asn Glu Glu Ala Lys Arg Lys Ser Pro Lys Lys Lys Glu Lys Cys Glu
            180                 185                 190         
Tyr Lys Lys Lys Ala Lys Asn Pro Lys Ser Pro Lys Val Gln Ala Val
        195                 200                 205             
Lys Asp Trp Ala Asn Gln Arg Cys Ser Ser Pro Lys Gly Ser Ala Arg
    210                 215                 220                 
Asn Ser Leu Val Lys Ala Lys Arg Lys Gly Ser Val Ser Val Cys Ser
225                 230                 235                 240 
Lys Glu Ser Pro Ser Ser Ser Ser Glu Ser Glu Ser Cys Asp Glu Ser
                245                 250                 255     
Ile Ser Asp Gly Pro Ser Lys Val Thr Leu Glu Ala Arg Asn Ser Ser
            260                 265                 270         
Glu Lys Leu Pro Thr Glu Leu Ser Lys Glu Glu Pro Ser Thr Lys Asn
        275                 280                 285             
Thr Thr Ala Asp Lys Leu Ala Ile Lys Leu Gly Phe Ser Leu Thr Pro
    290                 295                 300                 
Ser Lys Gly Lys Thr Ser Gly Thr Thr Ser Ser Ser Ser Asp Ser Ser
305                 310                 315                 320 
Ala Glu Ser Asp Asp Gln Cys Leu Met Ser Ser Ser Thr Pro Glu Cys
                325                 330                 335     
Ala Ala Gly Phe Leu Lys Thr Val Gly Leu Phe Ala Gly Arg Gly Arg
            340                 345                 350         
Pro Gly Pro Gly Leu Ser Ser Gln Thr Ala Gly Ala Ala Gly Trp Arg
        355                 360                 365             
Arg Ser Gly Ser Asn Gly Gly Gly Gln Ala Pro Gly Ala Ser Pro Ser
    370                 375                 380                 
Val Ser Leu Pro Ala Ser Leu Gly Arg Gly Trp Gly Arg Glu Glu Asn
385                 390                 395                 400 
Leu Phe Ser Trp Lys Gly Ala Lys Gly Arg Gly Met Arg Gly Arg Gly
                405                 410                 415     
Arg Gly Arg Gly His Pro Val Ser Cys Val Val Asn Arg Ser Thr Asp
            420                 425                 430         
Asn Gln Arg Gln Gln Gln Leu Asn Asp Val Val Lys Asn Ser Ser Thr
        435                 440                 445             
Ile Ile Gln Asn Pro Val Glu Thr Pro Lys Lys Asp Tyr Ser Leu Leu
    450                 455                 460                 
Pro Leu Leu Ala Ala Ala Pro Gln Val Gly Glu Lys Ile Ala Phe Lys
465                 470                 475                 480 
Leu Leu Glu Leu Thr Ser Ser Tyr Ser Pro Asp Val Ser Asp Tyr Lys
                485                 490                 495     
Glu Gly Arg Ile Leu Ser His Asn Pro Glu Thr Gln Gln Val Asp Ile
            500                 505                 510         
Glu Ile Leu Ser Ser Leu Pro Ala Leu Arg Glu Pro Gly Lys Phe Asp
        515                 520                 525             
Leu Val Tyr His Asn Glu Asn Gly Ala Glu Val Val Glu Tyr Ala Val
    530                 535                 540                 
Thr Gln Glu Ser Lys Ile Thr Val Phe Trp Lys Glu Leu Ile Asp Pro
545                 550                 555                 560 
Arg Leu Ile Ile Glu Ser Pro Ser Asn Thr Ser Ser Thr Glu Pro Ala
                565                 570                 575     


<210> 102
<211> 424
<212> PRT
<213> Homo sapiens

<400> 102
Met Ser Asp Ser Lys Cys Asp Ser Gln Phe Tyr Ser Val Gln Val Ala
 1               5                  10                  15      
Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Gln Leu Lys Pro Ile
            20                  25                  30          
Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Phe Asp Thr Val Leu
        35                  40                  45              
Gly Ile Asn Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln
    50                  55                  60                  
Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Leu Lys Cys Val
65                  70                  75                  80  
Asn His Lys Asn Ile Ile Ser Leu Leu Asn Val Phe Thr Pro Gln Lys
                85                  90                  95      
Thr Leu Glu Glu Phe Gln Asp Val Tyr Leu Val Met Glu Leu Met Asp
            100                 105                 110         
Ala Asn Leu Cys Gln Val Ile His Met Glu Leu Asp His Glu Arg Met
        115                 120                 125             
Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser
    130                 135                 140                 
Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys
145                 150                 155                 160 
Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala
                165                 170                 175     
Cys Thr Asn Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg
            180                 185                 190         
Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Ile
        195                 200                 205             
Trp Ser Val Gly Cys Ile Met Gly Glu Leu Val Lys Gly Cys Val Ile
    210                 215                 220                 
Phe Gln Gly Thr Asp His Ile Asp Gln Trp Asn Lys Val Ile Glu Gln
225                 230                 235                 240 
Leu Gly Thr Pro Ser Ala Glu Phe Met Lys Lys Leu Gln Pro Thr Val
                245                 250                 255     
Arg Asn Tyr Val Glu Asn Arg Pro Lys Tyr Pro Gly Ile Lys Phe Glu
            260                 265                 270         
Glu Leu Phe Pro Asp Trp Ile Phe Pro Ser Glu Ser Glu Arg Asp Lys
        275                 280                 285             
Ile Lys Thr Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile
    290                 295                 300                 
Asp Pro Asp Lys Arg Ile Ser Val Asp Glu Ala Leu Arg His Pro Tyr
305                 310                 315                 320 
Ile Thr Val Trp Tyr Asp Pro Ala Glu Ala Glu Ala Pro Pro Pro Gln
                325                 330                 335     
Ile Tyr Asp Ala Gln Leu Glu Glu Arg Glu His Ala Ile Glu Glu Trp
            340                 345                 350         
Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Trp Glu Glu Arg Ser Lys
        355                 360                 365             
Asn Gly Val Val Lys Asp Gln Pro Ser Asp Ala Ala Val Ser Ser Asn
    370                 375                 380                 
Ala Thr Pro Ser Gln Ser Ser Ser Ile Asn Asp Ile Ser Ser Met Ser
385                 390                 395                 400 
Thr Glu Gln Thr Leu Ala Ser Asp Thr Asp Ser Ser Leu Asp Ala Ser
                405                 410                 415     
Thr Gly Pro Leu Glu Gly Cys Arg
            420                 


<210> 103
<211> 697
<212> PRT
<213> Homo sapiens

<400> 103
Met Ala Gly Leu Gly Pro Gly Val Gly Asp Ser Glu Gly Gly Pro Arg
 1               5                  10                  15      
Pro Leu Phe Cys Arg Lys Gly Ala Leu Arg Gln Lys Val Val His Glu
            20                  25                  30          
Val Lys Ser His Lys Phe Thr Ala Arg Phe Phe Lys Gln Pro Thr Phe
        35                  40                  45              
Cys Ser His Cys Thr Asp Phe Ile Trp Gly Ile Gly Lys Gln Gly Leu
    50                  55                  60                  
Gln Cys Gln Val Cys Ser Phe Val Val His Arg Arg Cys His Glu Phe
65                  70                  75                  80  
Val Thr Phe Glu Cys Pro Gly Ala Gly Lys Gly Pro Gln Thr Asp Asp
                85                  90                  95      
Pro Arg Asn Lys His Lys Phe Arg Leu His Ser Tyr Ser Ser Pro Thr
            100                 105                 110         
Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Val His Gln Gly
        115                 120                 125             
Met Lys Cys Ser Cys Cys Glu Met Asn Val His Arg Arg Cys Val Arg
    130                 135                 140                 
Ser Val Pro Ser Leu Cys Gly Val Asp His Thr Glu Arg Arg Gly Arg
145                 150                 155                 160 
Leu Gln Leu Glu Ile Arg Ala Pro Thr Ala Asp Glu Ile His Val Thr
                165                 170                 175     
Val Gly Glu Ala Arg Asn Leu Ile Pro Met Asp Pro Asn Gly Leu Ser
            180                 185                 190         
Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Arg Asn Leu Thr
        195                 200                 205             
Lys Gln Lys Thr Arg Thr Val Lys Ala Thr Leu Asn Pro Val Trp Asn
    210                 215                 220                 
Glu Thr Phe Val Phe Asn Leu Lys Pro Gly Asp Val Glu Arg Arg Leu
225                 230                 235                 240 
Ser Val Glu Val Trp Asp Trp Asp Arg Thr Ser Arg Asn Asp Phe Met
                245                 250                 255     
Gly Ala Met Ser Phe Gly Val Ser Glu Leu Leu Lys Ala Pro Val Asp
            260                 265                 270         
Gly Trp Tyr Lys Leu Leu Asn Gln Glu Glu Gly Glu Tyr Tyr Asn Val
        275                 280                 285             
Pro Val Ala Asp Ala Asp Asn Cys Ser Leu Leu Gln Lys Phe Glu Ala
    290                 295                 300                 
Cys Asn Tyr Pro Leu Glu Leu Tyr Glu Arg Val Arg Met Gly Pro Ser
305                 310                 315                 320 
Ser Ser Pro Ile Pro Ser Pro Ser Pro Ser Pro Thr Asp Pro Lys Arg
                325                 330                 335     
Cys Phe Phe Gly Ala Ser Pro Gly Arg Leu His Ile Ser Asp Phe Ser
            340                 345                 350         
Phe Leu Met Val Leu Gly Lys Gly Ser Phe Gly Lys Val Met Leu Ala
        355                 360                 365             
Glu Arg Arg Gly Ser Asp Glu Leu Tyr Ala Ile Lys Ile Leu Lys Lys
    370                 375                 380                 
Asp Val Ile Val Gln Asp Asp Asp Val Asp Cys Thr Leu Val Glu Lys
385                 390                 395                 400 
Arg Val Leu Ala Leu Gly Gly Arg Gly Pro Gly Gly Arg Pro His Phe
                405                 410                 415     
Leu Thr Gln Leu His Ser Thr Phe Gln Thr Pro Asp Arg Leu Tyr Phe
            420                 425                 430         
Val Met Glu Tyr Val Thr Gly Gly Asp Leu Met Tyr His Ile Gln Gln
        435                 440                 445             
Leu Gly Lys Phe Lys Glu Pro His Ala Ala Phe Tyr Ala Ala Glu Ile
    450                 455                 460                 
Ala Ile Gly Leu Phe Phe Leu His Asn Gln Gly Ile Ile Tyr Arg Asp
465                 470                 475                 480 
Leu Lys Leu Asp Asn Val Met Leu Asp Ala Glu Gly His Ile Lys Ile
                485                 490                 495     
Thr Asp Phe Gly Met Cys Lys Glu Asn Val Phe Pro Gly Thr Thr Thr
            500                 505                 510         
Arg Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile Ile Ala
        515                 520                 525             
Tyr Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ser Phe Gly Val Leu
    530                 535                 540                 
Leu Tyr Glu Met Leu Ala Gly Gln Pro Pro Phe Asp Gly Glu Asp Glu
545                 550                 555                 560 
Glu Glu Leu Phe Gln Ala Ile Met Glu Gln Thr Val Thr Tyr Pro Lys
                565                 570                 575     
Ser Leu Ser Arg Glu Ala Val Ala Ile Cys Lys Gly Phe Leu Thr Lys
            580                 585                 590         
His Pro Gly Lys Arg Leu Gly Ser Gly Pro Asp Gly Glu Pro Thr Ile
        595                 600                 605             
Arg Ala His Gly Phe Phe Arg Trp Ile Asp Trp Glu Arg Leu Glu Arg
    610                 615                 620                 
Leu Glu Ile Pro Pro Pro Phe Arg Pro Arg Pro Cys Gly Arg Ser Gly
625                 630                 635                 640 
Glu Asn Phe Asp Lys Phe Phe Thr Arg Ala Ala Pro Ala Leu Thr Pro
                645                 650                 655     
Pro Asp Arg Leu Val Leu Ala Ser Ile Asp Gln Ala Asp Phe Gln Gly
            660                 665                 670         
Phe Thr Tyr Val Asn Pro Asp Phe Val His Pro Asp Ala Arg Ser Pro
        675                 680                 685             
Thr Ser Pro Val Pro Val Pro Val Met
    690                 695         


<210> 104
<211> 441
<212> PRT
<213> Homo sapiens

<400> 104
Met Lys Lys Phe Phe Gln Glu Phe Lys Ala Asp Ile Lys Phe Lys Ser
 1               5                  10                  15      
Ala Gly Pro Gly Gln Lys Leu Lys Glu Ser Val Gly Glu Lys Ala His
            20                  25                  30          
Lys Glu Lys Pro Asn Gln Pro Ala Pro Arg Pro Pro Arg Gln Gly Pro
        35                  40                  45              
Thr Asn Glu Ala Gln Met Ala Ala Ala Ala Ala Leu Ala Arg Leu Glu
    50                  55                  60                  
Gln Lys Gln Ser Arg Ala Trp Gly Pro Thr Ser Gln Asp Thr Ile Arg
65                  70                  75                  80  
Asn Gln Val Arg Lys Glu Leu Gln Ala Glu Ala Thr Val Ser Gly Ser
                85                  90                  95      
Pro Glu Ala Pro Gly Thr Asn Val Val Ser Glu Pro Arg Glu Glu Gly
            100                 105                 110         
Ser Ala His Leu Ala Val Pro Gly Val Tyr Phe Thr Cys Pro Leu Thr
        115                 120                 125             
Gly Ala Thr Leu Arg Lys Asp Gln Arg Asp Ala Cys Ile Lys Glu Ala
    130                 135                 140                 
Ile Leu Leu His Phe Ser Thr Asp Pro Val Ala Ala Ser Ile Met Lys
145                 150                 155                 160 
Ile Tyr Thr Phe Asn Lys Asp Gln Asp Arg Val Lys Leu Gly Val Asp
                165                 170                 175     
Thr Ile Ala Lys Tyr Leu Asp Asn Ile His Leu His Pro Glu Glu Glu
            180                 185                 190         
Lys Tyr Arg Lys Ile Lys Leu Gln Asn Lys Val Phe Gln Glu Arg Ile
        195                 200                 205             
Asn Cys Leu Glu Gly Thr His Glu Phe Phe Glu Ala Ile Gly Phe Gln
    210                 215                 220                 
Lys Val Leu Leu Pro Ala Gln Asp Gln Glu Asp Pro Glu Glu Phe Tyr
225                 230                 235                 240 
Val Leu Ser Glu Thr Thr Leu Ala Gln Pro Gln Ser Leu Glu Arg His
                245                 250                 255     
Lys Glu Gln Leu Leu Ala Ala Glu Pro Val Arg Ala Lys Leu Asp Arg
            260                 265                 270         
Gln Arg Arg Val Phe Gln Pro Ser Pro Leu Ala Ser Gln Phe Glu Leu
        275                 280                 285             
Pro Gly Asp Phe Phe Asn Leu Thr Ala Glu Glu Ile Lys Arg Glu Gln
    290                 295                 300                 
Arg Leu Arg Ser Glu Ala Val Glu Arg Leu Ser Val Leu Arg Thr Lys
305                 310                 315                 320 
Ala Met Arg Glu Lys Glu Glu Gln Arg Gly Leu Arg Lys Tyr Asn Tyr
                325                 330                 335     
Thr Leu Leu Arg Val Arg Leu Pro Asp Gly Cys Leu Leu Gln Gly Thr
            340                 345                 350         
Phe Tyr Ala Arg Glu Arg Leu Gly Ala Val Tyr Gly Phe Val Arg Glu
        355                 360                 365             
Ala Leu Gln Ser Asp Trp Leu Pro Phe Glu Leu Leu Ala Ser Gly Gly
    370                 375                 380                 
Gln Lys Leu Ser Glu Asp Glu Asn Leu Ala Leu Asn Glu Cys Gly Leu
385                 390                 395                 400 
Val Pro Ser Ala Leu Leu Thr Phe Ser Trp Asp Met Ala Val Leu Glu
                405                 410                 415     
Asp Ile Lys Ala Ala Gly Ala Glu Pro Asp Ser Ile Leu Lys Pro Glu
            420                 425                 430         
Leu Leu Ser Ala Ile Glu Lys Leu Leu
        435                 440     


<210> 105
<211> 737
<212> PRT
<213> Homo sapiens

<400> 105
Met Val Val Phe Asn Gly Leu Leu Lys Ile Lys Ile Cys Glu Ala Val
 1               5                  10                  15      
Ser Leu Lys Pro Thr Ala Trp Ser Leu Arg His Ala Val Gly Pro Arg
            20                  25                  30          
Pro Gln Thr Phe Leu Leu Asp Pro Tyr Ile Ala Leu Asn Val Asp Asp
        35                  40                  45              
Ser Arg Ile Gly Gln Thr Ala Thr Lys Gln Lys Thr Asn Ser Pro Ala
    50                  55                  60                  
Trp His Asp Glu Phe Val Thr Asp Val Cys Asn Gly Arg Lys Ile Glu
65                  70                  75                  80  
Leu Ala Val Phe His Asp Ala Pro Ile Gly Tyr Asp Asp Phe Val Ala
                85                  90                  95      
Asn Cys Thr Ile Gln Phe Glu Glu Leu Leu Gln Asn Gly Ser Arg His
            100                 105                 110         
Phe Glu Asp Trp Ile Asp Leu Glu Pro Glu Gly Arg Val Tyr Val Ile
        115                 120                 125             
Ile Asp Leu Ser Gly Ser Ser Gly Glu Ala Pro Lys Asp Asn Glu Glu
    130                 135                 140                 
Arg Val Phe Arg Glu Arg Met Arg Pro Arg Lys Arg Gln Gly Ala Val
145                 150                 155                 160 
Arg Arg Arg Val His Gln Val Asn Gly His Lys Phe Met Ala Thr Tyr
                165                 170                 175     
Leu Arg Gln Pro Thr Tyr Cys Ser His Cys Arg Asp Phe Ile Trp Gly
            180                 185                 190         
Val Ile Gly Lys Gln Gly Tyr Gln Cys Gln Val Cys Thr Cys Val Val
        195                 200                 205             
His Lys Arg Cys His Glu Leu Ile Ile Thr Lys Cys Ala Gly Leu Lys
    210                 215                 220                 
Lys Gln Glu Thr Pro Asp Gln Val Gly Ser Gln Arg Phe Ser Val Asn
225                 230                 235                 240 
Met Pro His Lys Phe Gly Ile His Asn Tyr Lys Val Pro Thr Phe Cys
                245                 250                 255     
Asp His Cys Gly Ser Leu Leu Trp Gly Leu Leu Arg Gln Gly Leu Gln
            260                 265                 270         
Cys Lys Val Cys Lys Met Asn Val His Arg Arg Cys Glu Thr Asn Val
        275                 280                 285             
Ala Pro Asn Cys Gly Val Asp Ala Arg Gly Ile Ala Lys Val Leu Ala
    290                 295                 300                 
Asp Leu Gly Val Thr Pro Asp Lys Ile Thr Asn Ser Gly Gln Arg Arg
305                 310                 315                 320 
Lys Lys Leu Ile Ala Gly Ala Glu Ser Pro Gln Pro Ala Ser Gly Ser
                325                 330                 335     
Ser Pro Ser Glu Glu Asp Arg Ser Lys Ser Ala Pro Thr Ser Pro Cys
            340                 345                 350         
Asp Gln Glu Ile Lys Glu Leu Glu Asn Asn Ile Arg Lys Ala Leu Ser
        355                 360                 365             
Phe Asp Asn Arg Gly Glu Glu His Arg Ala Ala Ser Ser Pro Asp Gly
    370                 375                 380                 
Gln Leu Met Ser Pro Gly Glu Asn Gly Glu Val Arg Gln Gly Gln Ala
385                 390                 395                 400 
Lys Arg Leu Gly Leu Asp Glu Phe Asn Phe Ile Lys Val Leu Gly Lys
                405                 410                 415     
Gly Ser Phe Gly Lys Val Met Leu Ala Glu Leu Lys Gly Lys Asp Glu
            420                 425                 430         
Val Tyr Ala Val Lys Val Leu Lys Lys Asp Val Ile Leu Gln Asp Asp
        435                 440                 445             
Asp Val Asp Cys Thr Met Thr Glu Lys Arg Ile Leu Ala Leu Ala Arg
    450                 455                 460                 
Lys His Pro Tyr Leu Thr Gln Leu Tyr Cys Cys Phe Gln Thr Lys Asp
465                 470                 475                 480 
Arg Leu Phe Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Phe
                485                 490                 495     
Gln Ile Gln Arg Ser Arg Lys Phe Asp Glu Pro Arg Ser Arg Phe Tyr
            500                 505                 510         
Ala Ala Glu Val Thr Ser Ala Leu Met Phe Leu His Gln His Gly Val
        515                 520                 525             
Ile Tyr Arg Asp Leu Lys Leu Asp Asn Ile Leu Leu Asp Ala Glu Gly
    530                 535                 540                 
His Cys Lys Leu Ala Asp Phe Gly Met Cys Lys Glu Gly Ile Leu Asn
545                 550                 555                 560 
Gly Val Thr Thr Thr Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro
                565                 570                 575     
Glu Ile Leu Gln Glu Leu Glu Tyr Gly Pro Ser Val Asp Trp Trp Ala
            580                 585                 590         
Leu Gly Val Leu Met Tyr Glu Met Met Ala Gly Gln Pro Pro Phe Glu
        595                 600                 605             
Ala Asp Asn Glu Asp Asp Leu Phe Glu Ser Ile Leu His Asp Asp Val
    610                 615                 620                 
Leu Tyr Pro Val Trp Leu Ser Lys Glu Ala Val Ser Ile Leu Lys Ala
625                 630                 635                 640 
Phe Met Thr Lys Asn Pro His Lys Arg Leu Gly Cys Val Ala Ser Gln
                645                 650                 655     
Asn Gly Glu Asp Ala Ile Lys Gln His Pro Phe Phe Lys Glu Ile Asp
            660                 665                 670         
Trp Val Leu Leu Glu Gln Lys Lys Ile Lys Pro Pro Phe Lys Pro Arg
        675                 680                 685             
Ile Lys Thr Lys Arg Asp Val Asn Asn Phe Asp Gln Asp Phe Thr Arg
    690                 695                 700                 
Glu Glu Pro Val Leu Thr Leu Val Asp Glu Ala Ile Val Lys Gln Ile
705                 710                 715                 720 
Asn Gln Glu Glu Phe Lys Gly Phe Ser Tyr Phe Gly Glu Asp Leu Met
                725                 730                 735     
Pro
    


<210> 106
<211> 183
<212> PRT
<213> Homo sapiens

<400> 106
Met Ser Ser Pro Ser Pro Gly Lys Arg Arg Met Asp Thr Asp Val Val
 1               5                  10                  15      
Lys Leu Ile Glu Ser Lys His Glu Val Thr Ile Leu Gly Gly Leu Asn
            20                  25                  30          
Glu Phe Val Val Lys Phe Tyr Gly Pro Gln Gly Thr Pro Tyr Glu Gly
        35                  40                  45              
Gly Val Trp Lys Val Arg Val Asp Leu Pro Asp Lys Tyr Pro Phe Lys
    50                  55                  60                  
Ser Pro Ser Ile Gly Phe Met Asn Lys Ile Phe His Pro Asn Ile Asp
65                  70                  75                  80  
Glu Ala Ser Gly Thr Val Cys Leu Asp Val Ile Asn Gln Thr Trp Thr
                85                  90                  95      
Ala Leu Tyr Asp Leu Thr Asn Ile Phe Glu Ser Phe Leu Pro Gln Leu
            100                 105                 110         
Leu Ala Tyr Pro Asn Pro Ile Asp Pro Leu Asn Gly Asp Ala Ala Ala
        115                 120                 125             
Met Tyr Leu His Arg Pro Glu Glu Tyr Lys Gln Lys Ile Lys Glu Tyr
    130                 135                 140                 
Ile Gln Lys Tyr Ala Thr Glu Glu Ala Leu Lys Glu Gln Glu Glu Gly
145                 150                 155                 160 
Thr Gly Asp Ser Ser Ser Glu Ser Ser Met Ser Asp Phe Ser Glu Asp
                165                 170                 175     
Glu Ala Gln Asp Met Glu Leu
            180             


<210> 107
<211> 1146
<212> PRT
<213> Homo sapiens

<400> 107
Met Val Leu Gly Thr Val Leu Leu Pro Pro Asn Ser Tyr Gly Arg Asp
 1               5                  10                  15      
Gln Asp Thr Ser Leu Cys Cys Leu Cys Thr Glu Ala Ser Glu Ser Ala
            20                  25                  30          
Leu Pro Asp Leu Thr Glu Ala Leu His Arg Pro Tyr Gly Cys Asp Val
        35                  40                  45              
Glu Pro Gln Ala Leu Asn Glu Ala Ile Arg Trp Ser Ser Lys Glu Asn
    50                  55                  60                  
Leu Leu Gly Ala Thr Glu Ser Asp Pro Asn Leu Phe Val Ala Leu Tyr
65                  70                  75                  80  
Asp Phe Val Ala Ser Gly Asp Asn Thr Leu Ser Ile Thr Lys Gly Glu
                85                  90                  95      
Lys Leu Arg Val Leu Gly Tyr Asn Gln Asn Gly Glu Trp Ser Glu Val
            100                 105                 110         
Arg Ser Lys Asn Gly Gln Gly Trp Val Pro Ser Asn Tyr Ile Thr Pro
        115                 120                 125             
Val Asn Ser Leu Glu Lys His Ser Trp Tyr His Gly Pro Val Ser Arg
    130                 135                 140                 
Ser Ala Ala Glu Tyr Leu Leu Ser Ser Leu Ile Asn Gly Ser Phe Leu
145                 150                 155                 160 
Val Arg Glu Ser Glu Ser Ser Pro Gly Gln Leu Ser Ile Ser Leu Arg
                165                 170                 175     
Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile Asn Thr Thr Ala Asp Gly
            180                 185                 190         
Lys Val Tyr Val Thr Ala Glu Ser Arg Phe Ser Thr Leu Ala Glu Leu
        195                 200                 205             
Val His His His Ser Thr Val Ala Asp Gly Leu Val Thr Thr Leu His
    210                 215                 220                 
Tyr Pro Ala Pro Lys Cys Asn Lys Pro Thr Val Tyr Gly Val Ser Pro
225                 230                 235                 240 
Ile His Asp Lys Trp Glu Met Glu Arg Thr Asp Ile Thr Met Lys His
                245                 250                 255     
Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val Tyr Val Gly Val Trp Lys
            260                 265                 270         
Lys Tyr Ser Leu Thr Val Ala Val Lys Thr Leu Lys Glu Asp Thr Met
        275                 280                 285             
Glu Val Glu Glu Phe Leu Lys Glu Ala Ala Val Met Lys Glu Ile Lys
    290                 295                 300                 
His Pro Asn Leu Val Gln Leu Leu Gly Val Cys Thr Leu Glu Pro Pro
305                 310                 315                 320 
Phe Tyr Ile Val Thr Glu Tyr Met Pro Tyr Gly Asn Leu Leu Asp Tyr
                325                 330                 335     
Leu Arg Glu Cys Asn Arg Glu Glu Val Thr Ala Val Val Leu Leu Tyr
            340                 345                 350         
Met Ala Thr Gln Ile Ser Ser Ala Met Glu Tyr Leu Glu Lys Lys Asn
        355                 360                 365             
Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Leu Val Gly Glu Asn
    370                 375                 380                 
His Val Val Lys Val Ala Asp Phe Gly Leu Ser Arg Leu Met Thr Gly
385                 390                 395                 400 
Asp Thr Tyr Thr Ala His Ala Gly Ala Lys Phe Pro Ile Lys Trp Thr
                405                 410                 415     
Ala Pro Glu Ser Leu Ala Tyr Asn Thr Phe Ser Ile Lys Ser Asp Val
            420                 425                 430         
Trp Ala Phe Gly Val Leu Leu Trp Glu Ile Ala Thr Tyr Gly Met Ser
        435                 440                 445             
Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val Tyr Asp Leu Leu Glu Lys
    450                 455                 460                 
Gly Tyr Arg Met Glu Gln Pro Glu Gly Cys Pro Pro Lys Val Tyr Glu
465                 470                 475                 480 
Leu Met Arg Ala Cys Trp Lys Trp Ser Pro Ala Asp Arg Pro Ser Phe
                485                 490                 495     
Ala Glu Thr His Gln Ala Phe Glu Thr Met Phe His Asp Ser Ser Ile
            500                 505                 510         
Ser Glu Glu Val Ala Glu Glu Leu Gly Arg Ala Ala Ser Ser Ser Ser
        515                 520                 525             
Val Val Pro Tyr Leu Pro Arg Leu Pro Ile Leu Pro Ser Lys Thr Arg
    530                 535                 540                 
Thr Leu Lys Lys Gln Val Glu Asn Lys Glu Asn Ile Glu Gly Ala Gln
545                 550                 555                 560 
Asp Ala Thr Glu Asn Ser Ala Ser Ser Leu Ala Pro Gly Phe Ile Arg
                565                 570                 575     
Gly Ala Gln Ala Ser Ser Gly Ser Pro Ala Leu Pro Arg Lys Gln Arg
            580                 585                 590         
Asp Lys Ser Pro Ser Ser Leu Leu Glu Asp Ala Lys Glu Thr Cys Phe
        595                 600                 605             
Thr Arg Asp Arg Lys Gly Gly Phe Phe Ser Ser Phe Met Lys Lys Arg
    610                 615                 620                 
Asn Ala Pro Thr Pro Pro Lys Arg Ser Ser Ser Phe Arg Glu Met Glu
625                 630                 635                 640 
Asn Gln Pro His Lys Lys Tyr Glu Leu Thr Gly Asn Phe Ser Ser Val
                645                 650                 655     
Ala Ser Leu Gln His Ala Asp Gly Phe Ser Phe Thr Pro Ala Gln Gln
            660                 665                 670         
Glu Ala Asn Leu Val Pro Pro Lys Cys Tyr Gly Gly Ser Phe Ala Gln
        675                 680                 685             
Arg Asn Leu Cys Asn Asp Asp Gly Gly Gly Gly Gly Gly Ser Gly Thr
    690                 695                 700                 
Ala Gly Gly Gly Trp Ser Gly Ile Thr Gly Phe Phe Thr Pro Arg Leu
705                 710                 715                 720 
Ile Lys Lys Thr Leu Gly Leu Arg Ala Gly Lys Pro Thr Ala Ser Asp
                725                 730                 735     
Asp Thr Ser Lys Pro Phe Pro Arg Ser Asn Ser Thr Ser Ser Met Ser
            740                 745                 750         
Ser Gly Leu Pro Glu Gln Asp Arg Met Ala Met Thr Leu Pro Arg Asn
        755                 760                 765             
Cys Gln Arg Ser Lys Leu Gln Leu Glu Arg Thr Val Ser Thr Ser Ser
    770                 775                 780                 
Gln Pro Glu Glu Asn Val Asp Arg Ala Asn Asp Met Leu Pro Lys Lys
785                 790                 795                 800 
Ser Glu Glu Ser Ala Ala Pro Ser Arg Glu Arg Pro Lys Ala Lys Leu
                805                 810                 815     
Leu Pro Arg Gly Ala Thr Ala Leu Pro Leu Arg Thr Pro Ser Gly Asp
            820                 825                 830         
Leu Ala Ile Thr Glu Lys Asp Pro Pro Gly Val Gly Val Ala Gly Val
        835                 840                 845             
Ala Ala Ala Pro Lys Gly Lys Glu Lys Asn Gly Gly Ala Arg Leu Gly
    850                 855                 860                 
Met Ala Gly Val Pro Glu Asp Gly Glu Gln Pro Gly Trp Pro Ser Pro
865                 870                 875                 880 
Ala Lys Ala Ala Pro Val Leu Pro Thr Thr His Asn His Lys Val Pro
                885                 890                 895     
Val Leu Ile Ser Pro Thr Leu Lys His Thr Pro Ala Asp Val Gln Leu
            900                 905                 910         
Ile Gly Thr Asp Ser Gln Gly Asn Lys Phe Lys Leu Leu Ser Glu His
        915                 920                 925             
Gln Val Thr Ser Ser Gly Asp Lys Asp Arg Pro Arg Arg Val Lys Pro
    930                 935                 940                 
Lys Cys Ala Pro Pro Pro Pro Pro Val Met Arg Leu Leu Gln His Pro
945                 950                 955                 960 
Ser Ile Cys Ser Asp Pro Thr Glu Glu Pro Thr Ala Leu Thr Ala Gly
                965                 970                 975     
Gln Ser Thr Ser Glu Thr Gln Glu Gly Gly Lys Lys Ala Ala Leu Gly
            980                 985                 990         
Ala Val Pro Ile Ser Gly Lys Ala Gly Arg Pro Val Met Pro Pro Pro
        995                 1000                1005            
Gln Val Pro Leu Pro Thr Ser Ser Ile Ser Pro Ala Lys Met Ala Asn
    1010                1015                1020                
Gly Thr Ala Gly Thr Lys Val Ala Leu Arg Lys Thr Lys Gln Ala Ala
1025                1030                1035               1040 
Glu Lys Ile Ser Ala Asp Lys Ile Ser Lys Glu Ala Leu Leu Glu Cys
                1045                1050                1055    
Ala Asp Leu Leu Ser Ser Ala Leu Thr Glu Pro Val Pro Asn Ser Gln
            1060                1065                1070        
Leu Val Asp Thr Gly His Gln Leu Leu Asp Tyr Cys Ser Gly Tyr Val
        1075                1080                1085            
Asp Cys Ile Pro Gln Thr Arg Asn Lys Phe Ala Phe Arg Glu Ala Val
    1090                1095                1100                
Ser Lys Leu Glu Leu Ser Leu Gln Glu Leu Gln Val Ser Ser Ala Ala
1105                1110                1115               1120 
Ala Gly Val Pro Gly Thr Asn Pro Val Leu Asn Asn Leu Leu Ser Cys
                1125                1130                1135    
Val Gln Glu Ile Ser Asp Val Val Gln Arg
            1140                1145    


<210> 108
<211> 365
<212> PRT
<213> Homo sapiens

<400> 108
Met Asn Arg Glu Asp Arg Asn Val Leu Arg Met Lys Glu Arg Glu Arg
 1               5                  10                  15      
Arg Asn Gln Glu Ile Gln Gln Gly Glu Asp Ala Phe Pro Pro Ser Ser
            20                  25                  30          
Pro Leu Phe Ala Glu Pro Tyr Lys Val Thr Ser Lys Glu Asp Lys Leu
        35                  40                  45              
Ser Ser Arg Ile Gln Ser Met Leu Gly Asn Tyr Asp Glu Met Lys Asp
    50                  55                  60                  
Phe Ile Gly Asp Arg Ser Ile Pro Lys Leu Val Ala Ile Pro Lys Pro
65                  70                  75                  80  
Thr Val Pro Pro Ser Ala Asp Glu Lys Ser Asn Pro Asn Phe Phe Glu
                85                  90                  95      
Gln Arg His Gly Gly Ser His Gln Ser Ser Lys Trp Thr Pro Val Gly
            100                 105                 110         
Pro Ala Pro Ser Thr Ser Gln Ser Gln Lys Arg Ser Ser Gly Leu Gln
        115                 120                 125             
Ser Gly His Ser Ser Gln Arg Thr Ser Ala Gly Ser Ser Ser Gly Thr
    130                 135                 140                 
Asn Ser Ser Gly Gln Arg His Asp Arg Glu Ser Tyr Asn Asn Ser Gly
145                 150                 155                 160 
Ser Ser Ser Arg Lys Lys Gly Gln His Gly Ser Glu His Ser Lys Ser
                165                 170                 175     
Arg Ser Ser Ser Pro Gly Lys Pro Gln Ala Val Ser Ser Leu Asn Ser
            180                 185                 190         
Ser His Ser Arg Ser His Gly Asn Asp His His Ser Lys Glu His Gln
        195                 200                 205             
Arg Ser Lys Ser Pro Arg Asp Pro Asp Ala Asn Trp Asp Ser Pro Ser
    210                 215                 220                 
Arg Val Pro Phe Ser Ser Gly Gln His Ser Thr Gln Ser Phe Pro Pro
225                 230                 235                 240 
Ser Leu Met Ser Lys Ser Asn Ser Met Leu Gln Lys Pro Thr Ala Tyr
                245                 250                 255     
Val Arg Pro Met Asp Gly Gln Glu Ser Met Glu Pro Lys Leu Ser Ser
            260                 265                 270         
Glu His Tyr Ser Ser Gln Ser His Gly Asn Ser Met Thr Glu Leu Lys
        275                 280                 285             
Pro Ser Ser Lys Ala His Leu Thr Lys Leu Lys Ile Pro Ser Gln Pro
    290                 295                 300                 
Leu Asp Ala Ser Ala Ser Gly Asp Val Ser Cys Val Asp Glu Ile Leu
305                 310                 315                 320 
Lys Glu Met Thr His Ser Trp Pro Pro Pro Leu Thr Ala Ile His Thr
                325                 330                 335     
Pro Cys Lys Thr Glu Pro Ser Lys Phe Pro Phe Pro Thr Lys Glu Ser
            340                 345                 350         
Gln Gln Ser Asn Phe Gly Thr Gly Glu Gln Arg Leu Lys
        355                 360                 365 


<210> 109
<211> 726
<212> PRT
<213> Homo sapiens

<400> 109
Met Glu Gly Glu Arg Lys Asn Asn Asn Lys Arg Trp Tyr Phe Thr Arg
 1               5                  10                  15      
Glu Gln Leu Glu Asn Ser Pro Ser Arg Arg Phe Gly Val Asp Pro Asp
            20                  25                  30          
Lys Glu Leu Ser Tyr Arg Gln Gln Ala Ala Asn Leu Leu Gln Asp Met
        35                  40                  45              
Gly Gln Arg Leu Asn Val Ser Gln Leu Thr Ile Asn Thr Ala Ile Val
    50                  55                  60                  
Tyr Met His Arg Phe Tyr Met Ile Gln Ser Phe Thr Gln Phe Pro Gly
65                  70                  75                  80  
Asn Ser Val Ala Pro Ala Ala Leu Phe Leu Ala Ala Lys Val Glu Glu
                85                  90                  95      
Gln Pro Lys Lys Leu Glu His Val Ile Lys Val Ala His Thr Cys Leu
            100                 105                 110         
His Pro Gln Glu Ser Leu Pro Asp Thr Arg Ser Glu Ala Tyr Leu Gln
        115                 120                 125             
Gln Val Gln Asp Leu Val Ile Leu Glu Ser Ile Ile Leu Gln Thr Leu
    130                 135                 140                 
Gly Phe Glu Leu Thr Ile Asp His Pro His Thr His Val Val Lys Cys
145                 150                 155                 160 
Thr Gln Leu Val Arg Ala Ser Lys Asp Leu Ala Gln Thr Ser Tyr Phe
                165                 170                 175     
Met Ala Thr Asn Ser Leu His Leu Thr Thr Phe Ser Leu Gln Tyr Thr
            180                 185                 190         
Pro Pro Val Val Ala Cys Val Cys Ile His Leu Ala Cys Lys Trp Ser
        195                 200                 205             
Asn Trp Glu Ile Pro Val Ser Thr Asp Gly Lys His Trp Trp Glu Tyr
    210                 215                 220                 
Val Asp Ala Thr Val Thr Leu Glu Leu Leu Asp Glu Leu Thr His Glu
225                 230                 235                 240 
Phe Leu Gln Ile Leu Glu Lys Thr Pro Asn Arg Leu Lys Arg Ile Trp
                245                 250                 255     
Asn Trp Arg Ala Cys Glu Ala Ala Lys Lys Thr Lys Ala Asp Asp Arg
            260                 265                 270         
Gly Thr Asp Glu Lys Thr Ser Glu Gln Thr Ile Leu Asn Met Ile Ser
        275                 280                 285             
Gln Ser Ser Ser Asp Thr Thr Ile Ala Gly Leu Met Ser Met Ser Thr
    290                 295                 300                 
Ser Thr Thr Ser Ala Val Pro Ser Leu Pro Val Ser Glu Glu Ser Ser
305                 310                 315                 320 
Ser Asn Leu Thr Ser Val Glu Met Leu Pro Gly Lys Arg Trp Leu Ser
                325                 330                 335     
Ser Gln Pro Ser Phe Lys Leu Glu Pro Thr Gln Gly His Arg Thr Ser
            340                 345                 350         
Glu Asn Leu Ala Leu Thr Gly Val Asp His Ser Leu Pro Gln Asp Gly
        355                 360                 365             
Ser Asn Ala Phe Ile Ser Gln Lys Gln Asn Ser Lys Ser Val Pro Ser
    370                 375                 380                 
Ala Lys Val Ser Leu Lys Glu Tyr Arg Ala Lys His Ala Glu Glu Leu
385                 390                 395                 400 
Ala Ala Gln Lys Arg Gln Leu Glu Asn Met Glu Ala Asn Val Lys Ser
                405                 410                 415     
Gln Tyr Ala Tyr Ala Ala Gln Asn Leu Leu Ser His His Asp Ser His
            420                 425                 430         
Ser Ser Val Ile Leu Lys Met Pro Ile Glu Gly Ser Glu Asn Pro Glu
        435                 440                 445             
Arg Pro Phe Leu Glu Lys Ala Asp Lys Thr Ala Leu Lys Met Arg Ile
    450                 455                 460                 
Pro Val Ala Gly Gly Asp Lys Ala Ala Ser Ser Lys Pro Glu Glu Ile
465                 470                 475                 480 
Lys Met Arg Ile Lys Val His Ala Ala Ala Asp Lys His Asn Ser Val
                485                 490                 495     
Glu Asp Ser Val Thr Lys Ser Arg Glu His Lys Glu Lys His Lys Thr
            500                 505                 510         
His Pro Ser Asn His His His His His Asn His His Ser His Lys His
        515                 520                 525             
Ser His Ser Gln Leu Pro Val Gly Thr Gly Asn Lys Arg Pro Gly Asp
    530                 535                 540                 
Pro Lys His Ser Ser Gln Thr Ser Asn Leu Ala His Lys Thr Tyr Ser
545                 550                 555                 560 
Leu Ser Ser Ser Phe Ser Ser Ser Ser Ser Thr Arg Lys Arg Gly Pro
                565                 570                 575     
Ser Glu Glu Thr Gly Gly Ala Val Phe Asp His Pro Ala Lys Ile Ala
            580                 585                 590         
Lys Ser Thr Lys Ser Ser Ser Leu Asn Phe Ser Phe Pro Ser Leu Pro
        595                 600                 605             
Thr Met Gly Gln Met Pro Gly His Ser Ser Asp Thr Ser Gly Leu Ser
    610                 615                 620                 
Phe Ser Gln Pro Ser Cys Lys Thr Arg Val Pro His Ser Lys Leu Asp
625                 630                 635                 640 
Lys Gly Pro Thr Gly Ala Asn Gly His Asn Thr Thr Gln Thr Ile Asp
                645                 650                 655     
Tyr Gln Asp Thr Val Asn Met Leu His Ser Leu Leu Ser Ala Gln Gly
            660                 665                 670         
Val Gln Pro Thr Gln Pro Thr Ala Phe Glu Phe Val Arg Pro Tyr Ser
        675                 680                 685             
Asp Tyr Leu Asn Pro Arg Ser Gly Gly Ile Ser Ser Arg Ser Gly Asn
    690                 695                 700                 
Thr Asp Lys Pro Arg Pro Pro Pro Leu Pro Ser Glu Pro Pro Pro Pro
705                 710                 715                 720 
Leu Pro Pro Leu Pro Lys
                725     


<210> 110
<211> 258
<212> PRT
<213> Homo sapiens

<400> 110
Met Thr His Asp Lys Ser Trp Arg Arg Cys Ser Ile Ser Gly Ser Thr
 1               5                  10                  15      
Lys Cys Arg Cys Gly Ser Arg Ile Ala Gly Pro Asn Ala Leu Gly Ser
            20                  25                  30          
Gly Gly Ser Arg Ser Ser Ser Ser Ser Ser Arg Ser Ile Leu Ser Ser
        35                  40                  45              
Ser Ile Leu Ser Ser Ser Ile Pro Ser Ser Ser Ser Ser Ser Ser Ser
    50                  55                  60                  
Pro Ser Ser Ser His Ser Ser Ser Ser Pro Ser Ser Ser His Ser Ser
65                  70                  75                  80  
Ser Ser Pro Ser Ser Ser Ser Ser Thr Ser Ser Pro Ser Ser Ser Ser
                85                  90                  95      
Ser Ser Ser Ser Ser Ser Ser Pro Ser Ser Ser Asn Ser Ser Ser Ser
            100                 105                 110         
Ser Ser Ser Ser Ser Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser
        115                 120                 125             
Pro Ser Ser Ser Ser Ser Ser Pro Ser Ser Ser Ser Ser Ser Ser Ser
    130                 135                 140                 
Ser Ser Pro Ser Ser Ser Ser Ser Ser Pro Ser Ser Ser Ser Ser Ser
145                 150                 155                 160 
Ser Ser Ser Ser Ser Ser Ser Pro Ser Ser Ser Ser Pro Ser Ser Ser
                165                 170                 175     
Gly Ser Ser Pro Ser Ser Ser Asn Ser Ser Pro Ser Ser Ser Ser Ser
            180                 185                 190         
Ser Pro Ser Ser Ser Ser Ser Ser Pro Ser Pro Arg Ser Ser Ser Pro
        195                 200                 205             
Ser Ser Ser Ser Ser Ser Thr Ser Ser Pro Ser Thr Ser Ser Pro Ser
    210                 215                 220                 
Ser Ser Ser Pro Ser Ser Ser Ser Pro Ser Ser Ser Cys Pro Ser Ala
225                 230                 235                 240 
Ala Leu Gly Arg Arg Pro Gln Ser Pro Gln Ser Ser His Cys Ala Pro
                245                 250                 255     
Phe Pro
        


<210> 111
<211> 358
<212> PRT
<213> Homo sapiens

<400> 111
Met Asp Asp Ala Thr Val Leu Arg Lys Lys Gly Tyr Ile Val Gly Ile
 1               5                  10                  15      
Asn Leu Gly Lys Gly Ser Tyr Ala Lys Val Lys Ser Ala Tyr Ser Glu
            20                  25                  30          
Arg Leu Lys Phe Asn Val Ala Val Lys Ile Ile Asp Arg Lys Lys Thr
        35                  40                  45              
Pro Thr Asp Phe Val Glu Arg Phe Leu Pro Arg Glu Met Asp Ile Leu
    50                  55                  60                  
Ala Thr Val Asn His Gly Ser Ile Ile Lys Thr Tyr Glu Ile Phe Glu
65                  70                  75                  80  
Thr Ser Asp Gly Arg Ile Tyr Ile Ile Met Glu Leu Gly Val Gln Gly
                85                  90                  95      
Asp Leu Leu Glu Phe Ile Lys Cys Gln Gly Ala Leu His Glu Asp Val
            100                 105                 110         
Ala Arg Lys Met Phe Arg Gln Leu Ser Ser Ala Val Lys Tyr Cys His
        115                 120                 125             
Asp Leu Asp Ile Val His Arg Asp Leu Lys Cys Glu Asn Leu Leu Leu
    130                 135                 140                 
Asp Lys Asp Phe Asn Ile Lys Leu Ser Asp Phe Gly Phe Ser Lys Arg
145                 150                 155                 160 
Cys Leu Arg Asp Ser Asn Gly Arg Ile Ile Leu Ser Lys Thr Phe Cys
                165                 170                 175     
Gly Ser Ala Ala Tyr Ala Ala Pro Glu Val Leu Gln Ser Ile Pro Tyr
            180                 185                 190         
Gln Pro Lys Val Tyr Asp Ile Trp Ser Leu Gly Val Ile Leu Tyr Ile
        195                 200                 205             
Met Val Cys Gly Ser Met Pro Tyr Asp Asp Ser Asp Ile Arg Lys Met
    210                 215                 220                 
Leu Arg Ile Gln Lys Glu His Arg Val Asp Phe Pro Arg Ser Lys Asn
225                 230                 235                 240 
Leu Thr Cys Glu Cys Lys Asp Leu Ile Tyr Arg Met Leu Gln Pro Asp
                245                 250                 255     
Val Ser Gln Arg Leu His Ile Asp Glu Ile Leu Ser His Ser Trp Leu
            260                 265                 270         
Gln Pro Pro Lys Pro Lys Ala Thr Ser Ser Ala Ser Phe Lys Arg Glu
        275                 280                 285             
Gly Glu Gly Lys Tyr Arg Ala Glu Cys Lys Leu Asp Thr Lys Thr Gly
    290                 295                 300                 
Leu Arg Pro Asp His Arg Pro Asp His Lys Leu Gly Ala Lys Thr Gln
305                 310                 315                 320 
His Arg Leu Leu Val Val Pro Glu Asn Glu Asn Arg Met Glu Asp Arg
                325                 330                 335     
Leu Ala Glu Thr Ser Arg Ala Lys Asp His His Ile Ser Gly Ala Glu
            340                 345                 350         
Val Gly Lys Ala Ser Thr
        355             


<210> 112
<211> 661
<212> PRT
<213> Homo sapiens

<400> 112
Met Glu Gly Ala Ala Ala Pro Val Ala Gly Asp Arg Pro Asp Leu Gly
 1               5                  10                  15      
Leu Gly Ala Pro Gly Ser Pro Arg Glu Ala Val Ala Gly Ala Thr Ala
            20                  25                  30          
Ala Leu Glu Pro Arg Lys Pro His Gly Val Lys Arg His His His Lys
        35                  40                  45              
His Asn Leu Lys His Arg Tyr Glu Leu Gln Glu Thr Leu Gly Lys Gly
    50                  55                  60                  
Thr Tyr Gly Lys Val Lys Arg Ala Thr Glu Arg Phe Ser Gly Arg Val
65                  70                  75                  80  
Val Ala Ile Lys Ser Ile Arg Lys Asp Lys Ile Lys Asp Glu Gln Asp
                85                  90                  95      
Met Val His Ile Arg Arg Glu Ile Glu Ile Met Ser Ser Leu Asn His
            100                 105                 110         
Pro His Ile Ile Ser Ile Tyr Glu Val Phe Glu Asn Lys Asp Lys Ile
        115                 120                 125             
Val Ile Ile Met Glu Tyr Ala Ser Lys Gly Glu Leu Tyr Asp Tyr Ile
    130                 135                 140                 
Ser Glu Arg Arg Arg Leu Ser Glu Arg Glu Thr Arg His Phe Phe Arg
145                 150                 155                 160 
Gln Ile Val Ser Ala Val His Tyr Cys His Lys Asn Gly Val Val His
                165                 170                 175     
Arg Asp Leu Lys Leu Glu Asn Ile Leu Leu Asp Asp Asn Cys Asn Ile
            180                 185                 190         
Lys Ile Ala Asp Phe Gly Leu Ser Asn Leu Tyr Gln Lys Asp Lys Phe
        195                 200                 205             
Leu Gln Thr Phe Cys Gly Ser Pro Leu Tyr Ala Ser Pro Glu Ile Val
    210                 215                 220                 
Asn Gly Arg Pro Tyr Arg Gly Pro Glu Val Asp Ser Trp Ala Leu Gly
225                 230                 235                 240 
Val Leu Leu Tyr Thr Leu Val Tyr Gly Thr Met Pro Phe Asp Gly Phe
                245                 250                 255     
Asp His Lys Asn Leu Ile Arg Gln Ile Ser Ser Gly Glu Tyr Arg Glu
            260                 265                 270         
Pro Thr Gln Pro Ser Asp Ala Arg Gly Leu Ile Arg Trp Met Leu Met
        275                 280                 285             
Val Asn Pro Asp Arg Arg Ala Thr Ile Glu Asp Ile Ala Asn His Trp
    290                 295                 300                 
Trp Val Asn Trp Gly Tyr Lys Ser Ser Val Cys Asp Cys Asp Ala Leu
305                 310                 315                 320 
His Asp Ser Glu Ser Pro Leu Leu Ala Arg Ile Ile Asp Trp His His
                325                 330                 335     
Arg Ser Thr Gly Leu Gln Ala Asp Thr Glu Ala Lys Met Lys Gly Leu
            340                 345                 350         
Ala Lys Pro Thr Thr Ser Glu Val Met Leu Glu Arg Gln Arg Ser Leu
        355                 360                 365             
Lys Lys Ser Lys Lys Glu Asn Asp Phe Ala Gln Ser Gly Gln Asp Ala
    370                 375                 380                 
Val Pro Glu Ser Pro Ser Lys Leu Ser Ser Lys Arg Pro Lys Gly Ile
385                 390                 395                 400 
Leu Lys Lys Arg Ser Asn Ser Glu His Arg Ser His Ser Thr Gly Phe
                405                 410                 415     
Ile Glu Gly Val Val Gly Pro Ala Leu Pro Ser Thr Phe Lys Met Glu
            420                 425                 430         
Gln Asp Leu Cys Arg Thr Gly Val Leu Leu Pro Ser Ser Pro Glu Ala
        435                 440                 445             
Glu Val Pro Gly Lys Leu Ser Pro Lys Gln Ser Ala Thr Met Pro Lys
    450                 455                 460                 
Lys Gly Ile Leu Lys Lys Thr Gln Gln Arg Glu Ser Gly Tyr Tyr Ser
465                 470                 475                 480 
Ser Pro Glu Arg Ser Glu Ser Ser Glu Leu Leu Asp Ser Asn Asp Val
                485                 490                 495     
Met Gly Ser Ser Ile Pro Ser Pro Ser Pro Pro Asp Pro Ala Arg Val
            500                 505                 510         
Thr Ser His Ser Leu Ser Cys Arg Arg Lys Gly Ile Leu Lys His Ser
        515                 520                 525             
Ser Lys Tyr Ser Ala Gly Thr Met Asp Pro Ala Leu Val Ser Pro Glu
    530                 535                 540                 
Met Pro Thr Leu Glu Ser Leu Ser Glu Pro Gly Val Pro Ala Glu Gly
545                 550                 555                 560 
Leu Ser Arg Ser Tyr Ser Arg Pro Ser Ser Val Ile Ser Asp Asp Ser
                565                 570                 575     
Val Leu Ser Ser Asp Ser Phe Asp Leu Leu Asp Leu Gln Glu Asn Arg
            580                 585                 590         
Pro Ala Arg Gln Arg Ile Arg Ser Cys Val Ser Ala Glu Asn Phe Leu
        595                 600                 605             
Gln Ile Gln Asp Phe Glu Gly Leu Gln Asn Arg Pro Arg Pro Gln Tyr
    610                 615                 620                 
Leu Lys Arg Tyr Arg Asn Arg Leu Ala Asp Ser Ser Phe Ser Leu Leu
625                 630                 635                 640 
Thr Asp Met Asp Asp Val Thr Gln Val Tyr Lys Gln Ala Leu Glu Ile
                645                 650                 655     
Cys Ser Lys Leu Asn
            660     


<210> 113
<211> 724
<212> PRT
<213> Homo sapiens

<400> 113
Met Ser Ser Ala Arg Thr Pro Leu Pro Thr Leu Asn Glu Arg Asp Thr
 1               5                  10                  15      
Glu Gln Pro Thr Leu Gly His Leu Asp Ser Lys Pro Ser Ser Lys Ser
            20                  25                  30          
Asn Met Ile Arg Gly Arg Asn Ser Ala Thr Ser Ala Asp Glu Gln Pro
        35                  40                  45              
His Ile Gly Asn Tyr Arg Leu Leu Lys Thr Ile Gly Lys Gly Asn Phe
    50                  55                  60                  
Ala Lys Val Lys Leu Ala Arg His Ile Leu Thr Gly Lys Glu Val Ala
65                  70                  75                  80  
Val Lys Ile Ile Asp Lys Thr Gln Leu Asn Ser Ser Ser Leu Gln Lys
                85                  90                  95      
Leu Phe Arg Glu Val Arg Ile Met Lys Val Leu Asn His Pro Asn Ile
            100                 105                 110         
Val Lys Leu Phe Glu Val Ile Glu Thr Glu Lys Thr Leu Tyr Leu Val
        115                 120                 125             
Met Glu Tyr Ala Ser Gly Gly Glu Val Phe Asp Tyr Leu Val Ala His
    130                 135                 140                 
Gly Arg Met Lys Glu Lys Glu Ala Arg Ala Lys Phe Arg Gln Ile Val
145                 150                 155                 160 
Ser Ala Val Gln Tyr Cys His Gln Lys Phe Ile Val His Arg Asp Leu
                165                 170                 175     
Lys Ala Glu Asn Leu Leu Leu Asp Ala Asp Met Asn Ile Lys Ile Ala
            180                 185                 190         
Asp Phe Gly Phe Ser Asn Glu Phe Thr Phe Gly Asn Lys Leu Asp Thr
        195                 200                 205             
Phe Cys Gly Ser Pro Pro Tyr Ala Ala Pro Glu Leu Phe Gln Gly Lys
    210                 215                 220                 
Lys Tyr Asp Gly Pro Glu Val Asp Val Trp Ser Leu Gly Val Ile Leu
225                 230                 235                 240 
Tyr Thr Leu Val Ser Gly Ser Leu Pro Phe Asp Gly Gln Asn Leu Lys
                245                 250                 255     
Glu Leu Arg Glu Arg Val Leu Arg Gly Lys Tyr Arg Ile Pro Phe Tyr
            260                 265                 270         
Met Ser Thr Asp Cys Glu Asn Leu Leu Lys Lys Phe Leu Ile Leu Asn
        275                 280                 285             
Pro Ser Lys Arg Gly Thr Leu Glu Gln Ile Met Lys Asp Arg Trp Met
    290                 295                 300                 
Asn Val Gly His Glu Asp Asp Glu Leu Lys Pro Tyr Val Glu Pro Leu
305                 310                 315                 320 
Pro Asp Tyr Lys Asp Pro Arg Arg Thr Glu Leu Met Val Ser Met Gly
                325                 330                 335     
Tyr Thr Arg Glu Glu Ile Gln Asp Ser Leu Val Gly Gln Arg Tyr Asn
            340                 345                 350         
Glu Val Met Ala Thr Tyr Leu Leu Leu Gly Tyr Lys Ser Ser Glu Leu
        355                 360                 365             
Glu Gly Asp Thr Ile Thr Leu Lys Pro Arg Pro Ser Ala Asp Leu Thr
    370                 375                 380                 
Asn Ser Ser Ala Pro Ser Pro Ser His Lys Val Gln Arg Ser Val Ser
385                 390                 395                 400 
Ala Asn Pro Lys Gln Arg Arg Phe Ser Asp Gln Ala Gly Pro Ala Ile
                405                 410                 415     
Pro Thr Ser Asn Ser Tyr Ser Lys Lys Thr Gln Ser Asn Asn Ala Glu
            420                 425                 430         
Asn Lys Arg Pro Glu Glu Asp Arg Glu Ser Gly Arg Lys Ala Ser Ser
        435                 440                 445             
Thr Ala Lys Val Pro Ala Ser Pro Leu Pro Gly Leu Glu Arg Lys Lys
    450                 455                 460                 
Thr Thr Pro Thr Pro Ser Thr Asn Ser Val Leu Ser Thr Ser Thr Asn
465                 470                 475                 480 
Arg Ser Arg Asn Ser Pro Leu Leu Glu Arg Ala Ser Leu Gly Gln Ala
                485                 490                 495     
Ser Ile Gln Asn Gly Lys Asp Ser Thr Ala Pro Gln Arg Val Pro Val
            500                 505                 510         
Ala Ser Pro Ser Ala His Asn Ile Ser Ser Ser Gly Gly Ala Pro Asp
        515                 520                 525             
Arg Thr Asn Phe Pro Arg Gly Val Ser Ser Arg Ser Thr Phe His Ala
    530                 535                 540                 
Gly Gln Leu Arg Gln Val Arg Asp Gln Gln Asn Leu Pro Tyr Gly Val
545                 550                 555                 560 
Thr Pro Ala Ser Pro Ser Gly His Ser Gln Gly Arg Arg Gly Ala Ser
                565                 570                 575     
Gly Ser Ile Phe Ser Lys Phe Thr Ser Lys Phe Val Arg Arg Asn Leu
            580                 585                 590         
Asn Glu Pro Glu Ser Lys Asp Arg Val Glu Thr Leu Arg Pro His Val
        595                 600                 605             
Val Gly Ser Gly Gly Asn Asp Lys Glu Lys Glu Glu Phe Arg Glu Ala
    610                 615                 620                 
Lys Pro Arg Ser Leu Arg Phe Thr Trp Ser Met Lys Thr Thr Ser Ser
625                 630                 635                 640 
Met Glu Pro Asn Glu Met Met Arg Glu Ile Arg Lys Val Leu Asp Ala
                645                 650                 655     
Asn Ser Cys Gln Ser Glu Leu His Glu Lys Tyr Met Leu Leu Cys Met
            660                 665                 670         
His Gly Thr Pro Gly His Glu Asp Phe Val Gln Trp Glu Met Glu Val
        675                 680                 685             
Cys Lys Leu Pro Arg Leu Ser Leu Asn Gly Val Arg Phe Lys Arg Ile
    690                 695                 700                 
Ser Gly Thr Ser Met Ala Phe Lys Asn Ile Ala Ser Lys Ile Ala Asn
705                 710                 715                 720 
Glu Leu Lys Leu
                


<210> 114
<211> 885
<212> PRT
<213> Homo sapiens

<400> 114
Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys
 1               5                  10                  15      
Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala
            20                  25                  30          
Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg
        35                  40                  45              
Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro
    50                  55                  60                  
Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp
65                  70                  75                  80  
Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp
                85                  90                  95      
Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr
            100                 105                 110         
Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser
        115                 120                 125             
Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu
    130                 135                 140                 
Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys
145                 150                 155                 160 
Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp
                165                 170                 175     
Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu
            180                 185                 190         
His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His
        195                 200                 205             
Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu
    210                 215                 220                 
Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu
225                 230                 235                 240 
Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr
                245                 250                 255     
His Cys Thr Leu Gln Ala Val Leu Ser Asp Asp Gly Met Gly Ile Gln
            260                 265                 270         
Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser
        275                 280                 285             
Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro
    290                 295                 300                 
Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp
305                 310                 315                 320 
Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro
                325                 330                 335     
Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His
            340                 345                 350         
Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg
        355                 360                 365             
Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly
    370                 375                 380                 
Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser
385                 390                 395                 400 
Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro
                405                 410                 415     
Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Val Lys Glu Pro
            420                 425                 430         
Ser Thr Pro Ala Phe Ser Trp Pro Trp Trp Tyr Val Leu Leu Gly Ala
        435                 440                 445             
Val Val Ala Ala Ala Cys Val Leu Ile Leu Ala Leu Phe Leu Val His
    450                 455                 460                 
Arg Arg Lys Lys Glu Thr Arg Tyr Gly Glu Val Phe Glu Pro Thr Val
465                 470                 475                 480 
Glu Arg Gly Glu Leu Val Val Arg Tyr Arg Val Arg Lys Ser Tyr Ser
                485                 490                 495     
Arg Arg Thr Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile Ser Glu Glu
            500                 505                 510         
Leu Lys Glu Lys Leu Arg Asp Val Met Val Asp Arg His Lys Val Ala
        515                 520                 525             
Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Ala Val Met Glu Gly
    530                 535                 540                 
Gln Leu Asn Gln Asp Asp Ser Ile Leu Lys Val Ala Val Lys Thr Met
545                 550                 555                 560 
Lys Ile Ala Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe Leu Ser Glu
                565                 570                 575     
Ala Val Cys Met Lys Glu Phe Asp His Pro Asn Val Met Arg Leu Ile
            580                 585                 590         
Gly Val Cys Phe Gln Gly Ser Glu Arg Glu Ser Phe Pro Ala Pro Val
        595                 600                 605             
Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His Ser Phe Leu Leu
    610                 615                 620                 
Tyr Ser Arg Leu Gly Asp Gln Pro Val Tyr Leu Pro Thr Gln Met Leu
625                 630                 635                 640 
Val Lys Phe Met Ala Asp Ile Ala Ser Gly Met Glu Tyr Leu Ser Thr
                645                 650                 655     
Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asn
            660                 665                 670         
Glu Asn Met Ser Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile
        675                 680                 685             
Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val
    690                 695                 700                 
Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys
705                 710                 715                 720 
Ser Asp Val Trp Ser Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg
                725                 730                 735     
Gly Gln Thr Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile Tyr Asp Tyr
            740                 745                 750         
Leu Arg Gln Gly Asn Arg Leu Lys Gln Pro Ala Asp Cys Leu Asp Gly
        755                 760                 765             
Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu Leu Asn Pro Gln Asp Arg
    770                 775                 780                 
Pro Ser Phe Thr Glu Leu Arg Glu Asp Leu Glu Asn Thr Leu Lys Ala
785                 790                 795                 800 
Leu Pro Pro Ala Gln Glu Pro Asp Glu Ile Leu Tyr Val Asn Met Asp
                805                 810                 815     
Glu Gly Gly Gly Tyr Pro Glu Pro Pro Gly Ala Ala Gly Gly Ala Asp
            820                 825                 830         
Pro Pro Thr Gln Pro Asp Pro Lys Asp Ser Cys Ser Cys Leu Thr Ala
        835                 840                 845             
Ala Glu Val His Pro Ala Gly Arg Tyr Val Leu Cys Pro Ser Thr Thr
    850                 855                 860                 
Pro Ser Pro Ala Gln Pro Ala Asp Arg Gly Ser Pro Ala Ala Pro Gly
865                 870                 875                 880 
Gln Glu Asp Gly Ala
                885 


<210> 115
<211> 297
<212> PRT
<213> Homo sapiens

<400> 115
Met Glu Asp Tyr Thr Lys Ile Glu Lys Ile Gly Glu Gly Thr Tyr Gly
 1               5                  10                  15      
Val Val Tyr Lys Gly Arg His Lys Thr Thr Gly Gln Val Val Ala Met
            20                  25                  30          
Lys Lys Ile Arg Leu Glu Ser Glu Glu Glu Gly Val Pro Ser Thr Ala
        35                  40                  45              
Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu Arg His Pro Asn Ile Val
    50                  55                  60                  
Ser Leu Gln Asp Val Leu Met Gln Asp Ser Arg Leu Tyr Leu Ile Phe
65                  70                  75                  80  
Glu Phe Leu Ser Met Asp Leu Lys Lys Tyr Leu Asp Ser Ile Pro Pro
                85                  90                  95      
Gly Gln Tyr Met Asp Ser Ser Leu Val Lys Ser Tyr Leu Tyr Gln Ile
            100                 105                 110         
Leu Gln Gly Ile Val Phe Cys His Ser Arg Arg Val Leu His Arg Asp
        115                 120                 125             
Leu Lys Pro Gln Asn Leu Leu Ile Asp Asp Lys Gly Thr Ile Lys Leu
    130                 135                 140                 
Ala Asp Phe Gly Leu Ala Arg Ala Phe Gly Ile Pro Ile Arg Val Tyr
145                 150                 155                 160 
Thr His Glu Val Val Thr Leu Trp Tyr Arg Ser Pro Glu Val Leu Leu
                165                 170                 175     
Gly Ser Ala Arg Tyr Ser Thr Pro Val Asp Ile Trp Ser Ile Gly Thr
            180                 185                 190         
Ile Phe Ala Glu Leu Ala Thr Lys Lys Pro Leu Phe His Gly Asp Ser
        195                 200                 205             
Glu Ile Asp Gln Leu Phe Arg Ile Phe Arg Ala Leu Gly Thr Pro Asn
    210                 215                 220                 
Asn Glu Val Trp Pro Glu Val Glu Ser Leu Gln Asp Tyr Lys Asn Thr
225                 230                 235                 240 
Phe Pro Lys Trp Lys Pro Gly Ser Leu Ala Ser His Val Lys Asn Leu
                245                 250                 255     
Asp Glu Asn Gly Leu Asp Leu Leu Ser Lys Met Leu Ile Tyr Asp Pro
            260                 265                 270         
Ala Lys Arg Ile Ser Gly Lys Met Ala Leu Asn His Pro Tyr Phe Asn
        275                 280                 285             
Asp Leu Asp Asn Gln Ile Lys Lys Met
    290                 295         


<210> 116
<211> 466
<212> PRT
<213> Homo sapiens

<400> 116
Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val
 1               5                  10                  15      
Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg
            20                  25                  30          
Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn
        35                  40                  45              
Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys
    50                  55                  60                  
Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val
65                  70                  75                  80  
Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly
                85                  90                  95      
Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe
            100                 105                 110         
Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn
        115                 120                 125             
Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu
    130                 135                 140                 
Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln
145                 150                 155                 160 
Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln
                165                 170                 175     
Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala
            180                 185                 190         
Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser
        195                 200                 205             
Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro
    210                 215                 220                 
Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln
225                 230                 235                 240 
Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser
                245                 250                 255     
Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro
            260                 265                 270         
His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro
        275                 280                 285             
Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg
    290                 295                 300                 
Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg
305                 310                 315                 320 
Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His
                325                 330                 335     
Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val Asp
            340                 345                 350         
Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val Glu
        355                 360                 365             
Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val Val
    370                 375                 380                 
Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro Ile
385                 390                 395                 400 
Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu Glu Lys Lys Thr Arg
                405                 410                 415     
Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly
            420                 425                 430         
Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg Gly Pro Pro Arg Gly
        435                 440                 445             
Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly Arg Gly Leu Ala Pro
    450                 455                 460                 
Arg Gln
465     


<210> 117
<211> 298
<212> PRT
<213> Homo sapiens

<400> 117
Met Val Thr Pro Ala Leu Gln Met Lys Lys Pro Lys Gln Phe Cys Arg
 1               5                  10                  15      
Arg Met Gly Gln Lys Lys Gln Arg Pro Ala Arg Ala Gly Gln Pro His
            20                  25                  30          
Ser Ser Ser Asp Ala Ala Gln Ala Pro Ala Glu Gln Pro His Ser Ser
        35                  40                  45              
Ser Asp Ala Ala Gln Ala Pro Cys Pro Arg Glu Arg Cys Leu Gly Pro
    50                  55                  60                  
Pro Thr Thr Pro Gly Pro Tyr Arg Ser Ile Tyr Phe Ser Ser Pro Lys
65                  70                  75                  80  
Gly His Leu Thr Arg Leu Gly Leu Glu Phe Phe Asp Gln Pro Ala Val
                85                  90                  95      
Pro Leu Ala Arg Ala Phe Leu Gly Gln Val Leu Val Arg Arg Leu Pro
            100                 105                 110         
Asn Gly Thr Glu Leu Arg Gly Arg Ile Val Glu Thr Glu Ala Tyr Leu
        115                 120                 125             
Gly Pro Glu Asp Glu Ala Ala His Ser Arg Gly Gly Arg Gln Thr Pro
    130                 135                 140                 
Arg Asn Arg Gly Met Phe Met Lys Pro Gly Thr Leu Tyr Val Tyr Ile
145                 150                 155                 160 
Ile Tyr Gly Met Tyr Phe Cys Met Asn Ile Ser Ser Gln Gly Asp Gly
                165                 170                 175     
Ala Cys Val Leu Leu Arg Ala Leu Glu Pro Leu Glu Gly Leu Glu Thr
            180                 185                 190         
Met Arg Gln Leu Arg Ser Thr Leu Arg Lys Gly Thr Ala Ser Arg Val
        195                 200                 205             
Leu Lys Asp Arg Glu Leu Cys Ser Gly Pro Ser Lys Leu Cys Gln Ala
    210                 215                 220                 
Leu Ala Ile Asn Lys Ser Phe Asp Gln Arg Asp Leu Ala Gln Asp Glu
225                 230                 235                 240 
Ala Val Trp Leu Glu Arg Gly Pro Leu Glu Pro Ser Glu Pro Ala Val
                245                 250                 255     
Val Ala Ala Ala Arg Val Gly Val Gly His Ala Gly Glu Trp Ala Arg
            260                 265                 270         
Lys Pro Leu Arg Phe Tyr Val Arg Gly Ser Pro Trp Val Ser Val Val
        275                 280                 285             
Asp Arg Val Ala Glu Gln Asp Thr Gln Ala
    290                 295             


<210> 118
<211> 581
<212> PRT
<213> Homo sapiens

<400> 118
Met Glu Asp Val Asn Ser Asn Val Asn Ala Asp Gln Glu Val Arg Lys
 1               5                  10                  15      
Leu Gln Glu Leu Val Lys Lys Leu Glu Lys Gln Asn Glu Gln Leu Arg
            20                  25                  30          
Ser Arg Ser Gly Ala Val Gln Gly Ala Gly Ser Leu Gly Pro Gly Ser
        35                  40                  45              
Pro Val Arg Ala Gly Ala Ser Ile Pro Ser Ser Gly Ala Ala Ser Pro
    50                  55                  60                  
Arg Gly Phe Pro Leu Gly Leu Ser Ala Lys Ser Gly Gly Gly Pro Gly
65                  70                  75                  80  
Ser Gly Pro Arg Arg Thr Ser Ser Glu Glu Leu Arg Asp Ala Thr Ser
                85                  90                  95      
Leu Leu Ala Ala Gly Glu Gly Gly Leu Leu Asp Glu Val Glu Pro Leu
            100                 105                 110         
Arg Pro Asp Glu Leu Glu Arg Leu Ser Gly Trp Glu Glu Glu Glu Glu
        115                 120                 125             
Ser Trp Leu Tyr Ser Ser Pro Lys Lys Lys Leu Thr Pro Met Gln Lys
    130                 135                 140                 
Ser Val Ser Pro Leu Val Trp Cys Arg Gln Val Leu Asp Tyr Pro Ser
145                 150                 155                 160 
Pro Asp Val Glu Cys Ala Lys Lys Ser Leu Ile His Lys Leu Asp Gln
                165                 170                 175     
Thr Met Ser Ala Leu Lys Arg Gln Asn Leu Tyr Asn Asn Pro Phe Asn
            180                 185                 190         
Ser Met Ser Tyr Thr Ser Pro Tyr Ser Pro Asn Ala Ser Ser Pro Tyr
        195                 200                 205             
Ser Ser Gly Phe Asn Ser Pro Ser Ser Thr Pro Val Arg Pro Pro Ile
    210                 215                 220                 
Val Lys Gln Leu Ile Leu Pro Gly Asn Ser Gly Asn Leu Lys Ser Ser
225                 230                 235                 240 
Asp Arg Asn Pro Pro Leu Ser Pro Gln Ser Ser Ile Asp Ser Glu Leu
                245                 250                 255     
Ser Ala Ser Glu Leu Asp Glu Asp Ser Ile Gly Ser Asn Tyr Lys Leu
            260                 265                 270         
Asn Asp Val Thr Asp Val Gln Ile Leu Ala Arg Met Gln Glu Glu Ser
        275                 280                 285             
Leu Arg Gln Glu Tyr Ala Ala Thr Thr Ser Arg Arg Ser Ser Gly Ser
    290                 295                 300                 
Ser Cys Asn Ser Thr Arg Arg Gly Thr Phe Ser Asp Gln Glu Leu Asp
305                 310                 315                 320 
Ala Gln Ser Leu Asp Asp Glu Asp Asp Asn Met His His Ala Val Tyr
                325                 330                 335     
Pro Ala Val Asn Arg Phe Ser Pro Ser Pro Arg Asn Ser Pro Arg Pro
            340                 345                 350         
Ser Pro Lys Gln Ser Pro Arg Asn Ser Pro Arg Ser Arg Ser Pro Ala
        355                 360                 365             
Arg Gly Ile Glu Tyr Ser Arg Val Ser Pro Gln Pro Met Ile Ser Arg
    370                 375                 380                 
Leu Gln Gln Pro Arg Leu Ser Leu Gln Gly His Pro Thr Asp Leu Gln
385                 390                 395                 400 
Thr Ser Asn Val Lys Asn Glu Glu Lys Leu Arg Arg Ser Leu Pro Asn
                405                 410                 415     
Leu Ser Arg Thr Ser Asn Thr Gln Val Asp Ser Val Lys Ser Ser Arg
            420                 425                 430         
Ser Asp Ser Asn Phe Gln Val Pro Asn Gly Gly Ile Pro Arg Met Gln
        435                 440                 445             
Pro Gln Ala Ser Ala Ile Pro Ser Pro Gly Lys Phe Arg Ser Pro Ala
    450                 455                 460                 
Ala Pro Ser Pro Leu Ala Leu Arg Gln Pro Val Lys Ala Phe Ser Asn
465                 470                 475                 480 
His Gly Ser Gly Ser Pro Gly Ser Gln Glu Ile Thr Gln Leu Thr Gln
                485                 490                 495     
Thr Thr Ser Ser Pro Gly Pro Pro Met Val Gln Ser Thr Val Ser Ala
            500                 505                 510         
Asn Pro Pro Ser Asn Ile Asn Ser Ala Thr Leu Thr Arg Pro Ala Gly
        515                 520                 525             
Thr Thr Ala Met Arg Ser Gly Leu Pro Arg Pro Ser Ala Pro Ser Ala
    530                 535                 540                 
Gly Gly Ile Pro Val Pro Arg Ser Lys Leu Ala Gln Pro Val Arg Arg
545                 550                 555                 560 
Ser Leu Pro Ala Pro Lys Thr Tyr Gly Ser Met Lys Asp Asp Ser Trp
                565                 570                 575     
Lys Asp Gly Cys Tyr
            580     


<210> 119
<211> 370
<212> PRT
<213> Homo sapiens

<400> 119
Met Ser His Pro Ser Pro Gln Ala Lys Pro Ser Asn Pro Ser Asn Pro
 1               5                  10                  15      
Arg Val Phe Phe Asp Val Asp Ile Gly Gly Glu Arg Val Gly Arg Ile
            20                  25                  30          
Val Leu Glu Leu Phe Ala Asp Ile Val Pro Lys Thr Ala Glu Asn Phe
        35                  40                  45              
Arg Ala Leu Cys Thr Gly Glu Lys Gly Ile Gly His Thr Thr Gly Lys
    50                  55                  60                  
Pro Leu His Phe Lys Gly Cys Pro Phe His Arg Ile Ile Lys Lys Phe
65                  70                  75                  80  
Met Ile Gln Gly Gly Asp Phe Ser Asn Gln Asn Gly Thr Gly Gly Glu
                85                  90                  95      
Ser Ile Tyr Gly Glu Lys Phe Glu Asp Glu Asn Phe His Tyr Lys His
            100                 105                 110         
Asp Arg Glu Gly Leu Leu Ser Met Ala Asn Ala Gly Arg Asn Thr Asn
        115                 120                 125             
Gly Ser Gln Phe Phe Ile Thr Thr Val Pro Thr Pro His Leu Asp Gly
    130                 135                 140                 
Lys His Val Val Phe Gly Gln Val Ile Lys Gly Ile Gly Val Ala Arg
145                 150                 155                 160 
Ile Leu Glu Asn Val Glu Val Lys Gly Glu Lys Pro Ala Lys Leu Cys
                165                 170                 175     
Val Ile Ala Glu Cys Gly Glu Leu Lys Glu Gly Asp Asp Gly Gly Ile
            180                 185                 190         
Phe Pro Lys Asp Gly Ser Gly Asp Ser His Pro Asp Phe Pro Glu Asp
        195                 200                 205             
Ala Asp Ile Asp Leu Lys Asp Val Asp Lys Ile Leu Leu Ile Thr Glu
    210                 215                 220                 
Asp Leu Lys Asn Ile Gly Asn Thr Phe Phe Lys Ser Gln Asn Trp Glu
225                 230                 235                 240 
Met Ala Ile Lys Lys Tyr Ala Glu Val Leu Arg Tyr Val Asp Ser Ser
                245                 250                 255     
Lys Ala Val Ile Glu Thr Ala Asp Arg Ala Lys Leu Gln Pro Ile Ala
            260                 265                 270         
Leu Ser Cys Val Leu Asn Ile Gly Ala Cys Lys Leu Lys Met Ser Asn
        275                 280                 285             
Trp Gln Gly Ala Ile Asp Ser Cys Leu Glu Ala Leu Glu Leu Asp Pro
    290                 295                 300                 
Ser Asn Thr Lys Ala Leu Tyr Arg Arg Ala Gln Gly Trp Gln Gly Leu
305                 310                 315                 320 
Lys Glu Tyr Asp Gln Ala Leu Ala Asp Leu Lys Lys Ala Gln Gly Ile
                325                 330                 335     
Ala Pro Glu Asp Lys Ala Ile Gln Ala Glu Leu Leu Lys Val Lys Gln
            340                 345                 350         
Lys Ile Lys Ala Gln Lys Asp Lys Glu Lys Ala Val Tyr Ala Lys Met
        355                 360                 365             
Phe Ala
    370 


<210> 120
<211> 354
<212> PRT
<213> Homo sapiens

<400> 120
Met Cys Gly Arg Thr Ser Cys His Leu Pro Arg Asp Val Leu Thr Arg
 1               5                  10                  15      
Ala Cys Ala Tyr Gln Asp Arg Arg Gly Gln Gln Arg Leu Pro Glu Trp
            20                  25                  30          
Arg Asp Pro Asp Lys Tyr Cys Pro Ser Tyr Asn Lys Ser Pro Gln Ser
        35                  40                  45              
Asn Ser Pro Val Leu Leu Ser Arg Leu His Phe Glu Lys Asp Ala Asp
    50                  55                  60                  
Ser Ser Glu Arg Ile Ile Ala Pro Met Arg Trp Gly Leu Val Pro Ser
65                  70                  75                  80  
Trp Phe Lys Glu Ser Asp Pro Ser Lys Leu Gln Phe Asn Thr Thr Asn
                85                  90                  95      
Cys Arg Ser Asp Thr Val Met Glu Lys Arg Ser Phe Lys Val Pro Leu
            100                 105                 110         
Gly Lys Gly Arg Arg Cys Val Val Leu Ala Asp Gly Phe Tyr Glu Trp
        115                 120                 125             
Gln Arg Cys Gln Gly Thr Asn Gln Arg Gln Pro Tyr Phe Ile Tyr Phe
    130                 135                 140                 
Pro Gln Ile Lys Thr Glu Lys Ser Gly Ser Ile Gly Ala Ala Asp Ser
145                 150                 155                 160 
Pro Glu Asn Trp Glu Lys Val Trp Asp Asn Trp Arg Leu Leu Thr Met
                165                 170                 175     
Ala Gly Ile Phe Asp Cys Trp Glu Pro Pro Glu Gly Gly Asp Val Leu
            180                 185                 190         
Tyr Ser Tyr Thr Ile Ile Thr Val Asp Ser Cys Lys Gly Leu Ser Asp
        195                 200                 205             
Ile His His Arg Met Pro Ala Ile Leu Asp Gly Glu Glu Ala Val Ser
    210                 215                 220                 
Lys Trp Leu Asp Phe Gly Glu Val Ser Thr Gln Glu Ala Leu Lys Leu
225                 230                 235                 240 
Ile His Pro Thr Glu Asn Ile Thr Phe His Ala Val Ser Ser Val Val
                245                 250                 255     
Asn Asn Ser Arg Asn Asn Thr Pro Glu Cys Leu Ala Pro Val Asp Leu
            260                 265                 270         
Val Val Lys Lys Glu Leu Arg Ala Ser Gly Ser Ser Gln Arg Met Leu
        275                 280                 285             
Gln Trp Leu Ala Thr Lys Ser Pro Lys Lys Glu Asp Ser Lys Thr Pro
    290                 295                 300                 
Gln Lys Glu Glu Ser Asp Val Pro Gln Trp Ser Ser Gln Phe Leu Gln
305                 310                 315                 320 
Lys Ser Pro Leu Pro Thr Lys Arg Gly Thr Ala Gly Leu Leu Glu Gln
                325                 330                 335     
Trp Leu Lys Arg Glu Lys Glu Glu Glu Pro Val Ala Lys Arg Pro Tyr
            340                 345                 350         
Ser Gln
        


<210> 121
<211> 365
<212> PRT
<213> Homo sapiens

<400> 121
Met Ser Leu Ile Arg Lys Lys Gly Phe Tyr Lys Gln Asp Val Asn Lys
 1               5                  10                  15      
Thr Ala Trp Glu Leu Pro Lys Thr Tyr Val Ser Pro Thr His Val Gly
            20                  25                  30          
Ser Gly Ala Tyr Gly Ser Val Cys Ser Ala Ile Asp Lys Arg Ser Gly
        35                  40                  45              
Glu Lys Val Ala Ile Lys Lys Leu Ser Arg Pro Phe Gln Ser Glu Ile
    50                  55                  60                  
Phe Ala Lys Arg Ala Tyr Arg Glu Leu Leu Leu Leu Lys His Met Gln
65                  70                  75                  80  
His Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Ser Ser
                85                  90                  95      
Leu Arg Asn Phe Tyr Asp Phe Tyr Leu Val Met Pro Phe Met Gln Thr
            100                 105                 110         
Asp Leu Gln Lys Ile Met Gly Met Glu Phe Ser Glu Glu Lys Ile Gln
        115                 120                 125             
Tyr Leu Val Tyr Gln Met Leu Lys Gly Leu Lys Tyr Ile His Ser Ala
    130                 135                 140                 
Gly Val Val His Arg Asp Leu Lys Pro Gly Asn Leu Ala Val Asn Glu
145                 150                 155                 160 
Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Ala Asp
                165                 170                 175     
Ala Glu Met Thr Gly Tyr Val Val Thr Arg Trp Tyr Arg Ala Pro Glu
            180                 185                 190         
Val Ile Leu Ser Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser
        195                 200                 205             
Val Gly Cys Ile Met Ala Glu Met Leu Thr Gly Lys Thr Leu Phe Lys
    210                 215                 220                 
Gly Lys Asp Tyr Leu Asp Gln Leu Thr Gln Ile Leu Lys Val Thr Gly
225                 230                 235                 240 
Val Pro Gly Thr Glu Phe Val Gln Lys Leu Asn Asp Lys Ala Ala Lys
                245                 250                 255     
Ser Tyr Ile Gln Ser Leu Pro Gln Thr Pro Arg Lys Asp Phe Thr Gln
            260                 265                 270         
Leu Phe Pro Arg Ala Ser Pro Gln Ala Ala Asp Leu Leu Glu Lys Met
        275                 280                 285             
Leu Glu Leu Asp Val Asp Lys Arg Leu Thr Ala Ala Gln Ala Leu Thr
    290                 295                 300                 
His Pro Phe Phe Glu Pro Phe Arg Asp Pro Glu Glu Glu Thr Glu Ala
305                 310                 315                 320 
Gln Gln Pro Phe Asp Asp Ser Leu Glu His Glu Lys Leu Thr Val Asp
                325                 330                 335     
Glu Trp Lys Gln His Ile Tyr Lys Glu Ile Val Asn Phe Ser Pro Ile
            340                 345                 350         
Ala Arg Lys Asp Ser Arg Arg Arg Ser Gly Met Lys Leu
        355                 360                 365 


<210> 122
<211> 70
<212> PRT
<213> Homo sapiens

<400> 122
Met Ser Glu Val Lys Ser Arg Lys Lys Ser Gly Pro Lys Gly Ala Pro
 1               5                  10                  15      
Ala Ala Glu Pro Gly Lys Arg Ser Glu Gly Gly Lys Thr Pro Val Ala
            20                  25                  30          
Arg Ser Ser Gly Gly Gly Gly Trp Ala Asp Pro Arg Thr Cys Leu Ser
        35                  40                  45              
Leu Leu Ser Leu Gly Thr Cys Leu Gly Leu Ala Cys Gly Arg Asn Leu
    50                  55                  60                  
Lys Leu Ser Trp Asn Asn
65                  70  


<210> 123
<211> 352
<212> PRT
<213> Homo sapiens

<400> 123
Met Ala Pro Lys Leu Ile Thr Val Leu Cys Leu Gly Phe Cys Leu Asn
 1               5                  10                  15      
Gln Lys Ile Cys Pro His Ala Gly Ala Gln Asp Lys Phe Ser Leu Ser
            20                  25                  30          
Ala Trp Pro Ser Pro Val Val Pro Leu Gly Gly Arg Val Thr Leu Ser
        35                  40                  45              
Cys His Ser His Leu Arg Phe Val Ile Trp Thr Ile Phe Gln Thr Thr
    50                  55                  60                  
Gly Thr Arg Ser His Glu Leu His Thr Gly Leu Ser Asn Asn Ile Thr
65                  70                  75                  80  
Ile Ser Pro Val Thr Pro Glu His Ala Gly Thr Tyr Arg Cys Val Gly
                85                  90                  95      
Ile Tyr Lys His Ala Ser Lys Trp Ser Ala Glu Ser Asn Ser Leu Lys
            100                 105                 110         
Ile Ile Val Thr Gly Leu Phe Thr Lys Pro Ser Ile Ser Ala His Pro
        115                 120                 125             
Ser Ser Leu Val His Ala Gly Ala Arg Val Ser Leu Arg Cys His Ser
    130                 135                 140                 
Glu Leu Ala Phe Asp Glu Phe Ile Leu Tyr Lys Glu Gly His Ile Gln
145                 150                 155                 160 
His Ser Gln Gln Leu Asp Gln Gly Met Glu Ala Gly Ile His Tyr Val
                165                 170                 175     
Glu Ala Val Phe Ser Met Gly Pro Val Thr Pro Ala His Ala Gly Ala
            180                 185                 190         
Tyr Arg Cys Cys Gly Cys Phe Ser His Ser Arg Tyr Glu Trp Ser Ala
        195                 200                 205             
Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Lys Tyr Lys Lys Pro
    210                 215                 220                 
Ser Leu Ser Thr Gln Val Asp Pro Met Met Arg Leu Gly Glu Lys Leu
225                 230                 235                 240 
Thr Leu Phe Cys Ser Ser Glu Ile Ser Phe Asp Gln Tyr His Leu Phe
                245                 250                 255     
Arg His Gly Val Ala His Gly Gln Trp Leu Ser Gly Gly Gln Arg His
            260                 265                 270         
Arg Glu Ala Phe Gln Ala Asn Phe Ser Val Gly Arg Ala Thr Pro Val
        275                 280                 285             
Pro Gly Gly Thr Tyr Arg Cys Tyr Gly Ser Phe Asn Asp Ser Pro Tyr
    290                 295                 300                 
Lys Pro Pro Val Thr Arg Cys Asn Phe Thr Pro Gln Glu Thr Leu Arg
305                 310                 315                 320 
Val Leu Leu Cys His Ser Gln Asn Pro Pro Leu Asn Leu Thr His Leu
                325                 330                 335     
Ala Leu Lys Asp Ser Pro Ala Thr Cys Ile Cys Ser Leu Asp Ser Gln
            340                 345                 350         


<210> 124
<211> 365
<212> PRT
<213> Homo sapiens

<400> 124
Met Ala Lys Val Ala Lys Asp Leu Asn Pro Gly Val Lys Lys Met Ser
 1               5                  10                  15      
Leu Gly Gln Leu Gln Ser Ala Arg Gly Val Ala Cys Leu Gly Cys Lys
            20                  25                  30          
Gly Thr Cys Ser Gly Phe Glu Pro His Ser Trp Arg Lys Ile Cys Lys
        35                  40                  45              
Ser Cys Lys Cys Ser Gln Glu Asp His Cys Leu Thr Ser Asp Leu Glu
    50                  55                  60                  
Asp Asp Arg Lys Ile Gly Arg Leu Leu Met Asp Ser Lys Tyr Ser Thr
65                  70                  75                  80  
Leu Thr Ala Arg Val Lys Gly Gly Asp Gly Ile Arg Ile Tyr Lys Arg
                85                  90                  95      
Asn Arg Met Ile Met Thr Asn Pro Ile Ala Thr Gly Lys Asp Pro Thr
            100                 105                 110         
Phe Asp Thr Ile Thr Tyr Glu Trp Ala Pro Pro Gly Val Thr Gln Lys
        115                 120                 125             
Leu Gly Leu Gln Tyr Met Glu Leu Ile Pro Lys Glu Lys Gln Pro Val
    130                 135                 140                 
Thr Gly Thr Glu Gly Ala Phe Tyr Arg Arg Arg Gln Leu Met His Gln
145                 150                 155                 160 
Leu Pro Ile Tyr Asp Gln Asp Pro Ser Arg Cys Arg Gly Leu Leu Glu
                165                 170                 175     
Asn Glu Leu Lys Leu Met Glu Glu Phe Val Lys Gln Tyr Lys Ser Glu
            180                 185                 190         
Ala Leu Gly Val Gly Glu Val Ala Leu Pro Gly Gln Gly Gly Leu Pro
        195                 200                 205             
Lys Glu Glu Gly Lys Gln Gln Glu Lys Pro Glu Gly Ala Glu Thr Thr
    210                 215                 220                 
Ala Ala Thr Thr Asn Gly Ser Leu Ser Asp Pro Ser Lys Glu Val Glu
225                 230                 235                 240 
Tyr Val Cys Glu Leu Cys Lys Gly Ala Ala Pro Pro Asp Ser Pro Val
                245                 250                 255     
Val Tyr Ser Asp Arg Ala Gly Tyr Asn Lys Gln Trp His Pro Thr Cys
            260                 265                 270         
Phe Val Cys Ala Lys Cys Ser Glu Pro Leu Val Asp Leu Ile Tyr Phe
        275                 280                 285             
Trp Lys Asp Gly Ala Pro Trp Cys Gly Arg His Tyr Cys Glu Ser Leu
    290                 295                 300                 
Arg Pro Arg Cys Ser Gly Cys Asp Glu Ile Ile Phe Ala Glu Asp Tyr
305                 310                 315                 320 
Gln Arg Val Glu Asp Leu Ala Trp His Arg Lys His Phe Val Cys Glu
                325                 330                 335     
Gly Cys Glu Gln Leu Leu Ser Gly Arg Ala Tyr Ile Val Thr Lys Gly
            340                 345                 350         
Gln Leu Leu Cys Pro Thr Cys Ser Lys Ser Lys Arg Ser
        355                 360                 365 


<210> 125
<211> 601
<212> PRT
<213> Homo sapiens

<400> 125
Met Pro Glu Arg Glu Leu Trp Pro Ala Gly Thr Gly Ser Glu Pro Val
 1               5                  10                  15      
Thr Arg Val Gly Ser Cys Asp Ser Met Met Ser Ser Thr Ser Thr Arg
            20                  25                  30          
Ser Gly Ser Ser Asp Ser Ser Tyr Asp Phe Leu Ser Thr Glu Glu Lys
        35                  40                  45              
Glu Cys Leu Leu Phe Leu Glu Glu Thr Ile Gly Ser Leu Asp Thr Glu
    50                  55                  60                  
Ala Asp Ser Gly Leu Ser Thr Asp Glu Ser Glu Pro Ala Thr Thr Pro
65                  70                  75                  80  
Arg Gly Phe Arg Ala Leu Pro Ile Thr Gln Pro Thr Pro Arg Gly Gly
                85                  90                  95      
Pro Glu Glu Thr Ile Thr Gln Gln Gly Arg Thr Pro Arg Thr Val Thr
            100                 105                 110         
Glu Ser Ser Ser Ser His Pro Pro Glu Pro Gln Gly Leu Gly Leu Arg
        115                 120                 125             
Ser Gly Ser Tyr Ser Leu Pro Arg Asn Ile His Ile Ala Arg Ser Gln
    130                 135                 140                 
Asn Phe Arg Lys Ser Thr Thr Gln Ala Ser Ser His Asn Pro Gly Glu
145                 150                 155                 160 
Pro Gly Arg Leu Ala Pro Glu Pro Glu Lys Glu Gln Val Ser Gln Ser
                165                 170                 175     
Ser Gln Pro Arg Gln Ala Pro Ala Ser Pro Gln Glu Ala Ala Leu Asp
            180                 185                 190         
Leu Asp Val Val Leu Ile Pro Pro Pro Glu Ala Phe Arg Asp Thr Gln
        195                 200                 205             
Pro Glu Gln Cys Arg Glu Ala Ser Leu Pro Glu Gly Pro Gly Gln Gln
    210                 215                 220                 
Gly His Thr Pro Gln Leu His Thr Pro Ser Ser Ser Gln Glu Arg Glu
225                 230                 235                 240 
Gln Thr Pro Ser Glu Ala Met Ser Gln Lys Ala Lys Glu Thr Val Ser
                245                 250                 255     
Thr Arg Tyr Thr Gln Pro Gln Pro Pro Pro Ala Gly Leu Pro Gln Asn
            260                 265                 270         
Ala Arg Ala Glu Asp Ala Pro Leu Ser Ser Gly Glu Asp Pro Asn Ser
        275                 280                 285             
Arg Leu Ala Pro Leu Thr Thr Pro Lys Pro Arg Lys Leu Pro Pro Asn
    290                 295                 300                 
Ile Val Leu Lys Ser Ser Arg Ser Ser Phe His Ser Asp Pro Gln His
305                 310                 315                 320 
Trp Leu Ser Arg His Thr Glu Ala Ala Pro Gly Asp Ser Gly Leu Ile
                325                 330                 335     
Ser Cys Ser Leu Gln Glu Gln Arg Lys Ala Arg Lys Glu Ala Leu Glu
            340                 345                 350         
Lys Leu Gly Leu Pro Gln Asp Gln Asp Glu Pro Gly Leu His Leu Ser
        355                 360                 365             
Lys Pro Thr Ser Ser Ile Arg Pro Lys Glu Thr Arg Ala Gln His Leu
    370                 375                 380                 
Ser Pro Ala Pro Gly Leu Ala Gln Pro Ala Ala Pro Ala Gln Ala Ser
385                 390                 395                 400 
Ala Ala Ile Pro Ala Ala Gly Lys Ala Leu Ala Gln Ala Pro Ala Pro
                405                 410                 415     
Ala Pro Gly Pro Ala Gln Gly Pro Leu Pro Met Lys Ser Pro Ala Pro
            420                 425                 430         
Gly Asn Val Ala Ala Ser Lys Ser Met Pro Ile Ser Ile Pro Lys Ala
        435                 440                 445             
Pro Arg Ala Asn Ser Ala Leu Thr Pro Pro Lys Pro Glu Ser Gly Leu
    450                 455                 460                 
Thr Leu Gln Glu Ser Asn Thr Pro Gly Leu Arg Gln Met Asn Phe Lys
465                 470                 475                 480 
Ser Asn Thr Leu Glu Arg Ser Gly Val Gly Leu Ser Ser Tyr Leu Ser
                485                 490                 495     
Thr Glu Lys Asp Ala Ser Pro Lys Thr Ser Thr Ser Leu Gly Lys Gly
            500                 505                 510         
Ser Phe Leu Asp Lys Ile Ser Pro Ser Val Leu Arg Asn Ser Arg Pro
        515                 520                 525             
Arg Pro Ala Ser Leu Gly Thr Gly Lys Asp Phe Ala Gly Ile Gln Val
    530                 535                 540                 
Gly Lys Leu Ala Asp Leu Glu Gln Glu Gln Ser Ser Lys Arg Leu Ser
545                 550                 555                 560 
Tyr Gln Gly Gln Ser Arg Asp Lys Leu Pro Arg Pro Pro Cys Val Ser
                565                 570                 575     
Val Lys Ile Ser Pro Lys Gly Val Pro Asn Glu His Arg Arg Glu Ala
            580                 585                 590         
Leu Lys Lys Leu Gly Leu Leu Lys Glu
        595                 600     


<210> 126
<211> 433
<212> PRT
<213> Homo sapiens

<400> 126
Met Ser Gly Arg Pro Arg Thr Thr Ser Phe Ala Glu Ser Cys Lys Pro
 1               5                  10                  15      
Val Gln Gln Pro Ser Ala Phe Gly Ser Met Lys Val Ser Arg Asp Lys
            20                  25                  30          
Asp Gly Ser Lys Val Thr Thr Val Val Ala Thr Pro Gly Gln Gly Pro
        35                  40                  45              
Asp Arg Pro Gln Glu Val Ser Tyr Thr Asp Thr Lys Val Ile Gly Asn
    50                  55                  60                  
Gly Ser Phe Gly Val Val Tyr Gln Ala Lys Leu Cys Asp Ser Gly Glu
65                  70                  75                  80  
Leu Val Ala Ile Lys Lys Val Leu Gln Asp Lys Arg Phe Lys Asn Arg
                85                  90                  95      
Glu Leu Gln Ile Met Arg Lys Leu Asp His Cys Asn Ile Val Arg Leu
            100                 105                 110         
Arg Tyr Phe Phe Tyr Ser Ser Gly Glu Lys Lys Asp Glu Val Tyr Leu
        115                 120                 125             
Asn Leu Val Leu Asp Tyr Val Pro Glu Thr Val Tyr Arg Val Ala Arg
    130                 135                 140                 
His Tyr Ser Arg Ala Lys Gln Thr Leu Pro Val Ile Tyr Val Lys Leu
145                 150                 155                 160 
Tyr Met Tyr Gln Leu Phe Arg Ser Leu Ala Tyr Ile His Ser Phe Gly
                165                 170                 175     
Ile Cys His Arg Asp Ile Lys Pro Gln Asn Leu Leu Leu Asp Pro Asp
            180                 185                 190         
Thr Ala Val Leu Lys Leu Cys Asp Phe Gly Ser Ala Lys Gln Leu Val
        195                 200                 205             
Arg Gly Glu Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala
    210                 215                 220                 
Pro Glu Leu Ile Phe Gly Ala Thr Asp Tyr Thr Ser Ser Ile Asp Val
225                 230                 235                 240 
Trp Ser Ala Gly Cys Val Leu Ala Glu Leu Leu Leu Gly Gln Pro Ile
                245                 250                 255     
Phe Pro Gly Asp Ser Gly Val Asp Gln Leu Val Glu Ile Ile Lys Val
            260                 265                 270         
Leu Gly Thr Pro Thr Arg Glu Gln Ile Arg Glu Met Asn Pro Asn Tyr
        275                 280                 285             
Thr Glu Phe Lys Phe Pro Gln Ile Lys Ala His Pro Trp Thr Lys Asp
    290                 295                 300                 
Ser Ser Gly Thr Gly His Phe Thr Ser Gly Val Arg Val Phe Arg Pro
305                 310                 315                 320 
Arg Thr Pro Pro Glu Ala Ile Ala Leu Cys Ser Arg Leu Leu Glu Tyr
                325                 330                 335     
Thr Pro Thr Ala Arg Leu Thr Pro Leu Glu Ala Cys Ala His Ser Phe
            340                 345                 350         
Phe Asp Glu Leu Arg Asp Pro Asn Val Lys Leu Pro Asn Gly Arg Asp
        355                 360                 365             
Thr Pro Ala Leu Phe Asn Phe Thr Thr Gln Glu Leu Ser Ser Asn Pro
    370                 375                 380                 
Pro Leu Ala Thr Ile Leu Ile Pro Pro His Ala Arg Ile Gln Ala Ala
385                 390                 395                 400 
Ala Ser Thr Pro Thr Asn Ala Thr Ala Ala Ser Asp Ala Asn Thr Gly
                405                 410                 415     
Asp Arg Gly Gln Thr Asn Asn Ala Ala Ser Ala Ser Ala Ser Asn Ser
            420                 425                 430         
Thr
    


<210> 127
<211> 40
<212> PRT
<213> Homo sapiens

<400> 127
Leu Arg Ser Cys Gln Gly Tyr Lys Gln Cys Asn Pro Arg Pro Lys Asn
 1               5                  10                  15      
Leu Asp Val Gly Asn Lys Asp Gly Gly Ser Tyr Asp Leu His Arg Gly
            20                  25                  30          
Gln Leu Trp Asp Gly Trp Glu Gly
        35                  40  


<210> 128
<211> 637
<212> PRT
<213> Homo sapiens

<400> 128
Met Thr Lys Arg Lys Lys Leu Arg Thr Ser Gly Glu Gly Leu Cys Pro
 1               5                  10                  15      
Pro Lys Pro Leu Lys Asn Pro Arg Leu Gly Asp Phe Tyr Gly Asp Pro
            20                  25                  30          
Gln Ser Ser Met Leu Gly Cys Leu His His Pro Glu Glu Pro Glu Gly
        35                  40                  45              
Lys Leu Gly Pro Val Pro Ser Thr Gln Gln His Gly Glu Glu Pro Gly
    50                  55                  60                  
Lys Ala Val Ser Ser Ser Pro Asp Glu Glu Thr Gly Ser Pro Cys Arg
65                  70                  75                  80  
Leu Leu Arg Gln Pro Glu Lys Glu Pro Ala Pro Leu Pro Pro Ser Gln
                85                  90                  95      
Asn Ser Phe Gly Arg Phe Val Pro Gln Phe Ala Lys Ser Arg Lys Thr
            100                 105                 110         
Val Thr Arg Lys Glu Glu Met Lys Asp Glu Asp Arg Gly Ser Gly Ala
        115                 120                 125             
Phe Ser Leu Glu Thr Ile Ala Glu Ser Ser Ala Gln Ser Pro Gly Cys
    130                 135                 140                 
Gln Leu Leu Val Glu Thr Leu Gly Val Pro Leu Gln Glu Ala Thr Glu
145                 150                 155                 160 
Leu Gly Asp Pro Thr Gln Ala Asp Ser Ala Arg Pro Glu Gln Ser Ser
                165                 170                 175     
Gln Ser Pro Val Gln Ala Val Pro Gly Ser Gly Asp Ser Gln Pro Asp
            180                 185                 190         
Asp Pro Pro Asp Arg Gly Thr Gly Leu Ser Ala Ser Gln Arg Ala Ser
        195                 200                 205             
Gln Asp His Leu Ser Glu Gln Gly Ala Asp Asp Ser Lys Pro Glu Thr
    210                 215                 220                 
Asp Arg Val Pro Gly Asp Gly Gly Gln Lys Glu His Leu Pro Ser Ile
225                 230                 235                 240 
Asp Ser Glu Gly Glu Lys Pro Asp Arg Gly Ala Pro Gln Glu Gly Gly
                245                 250                 255     
Ala Gln Arg Thr Ala Gly Ala Gly Leu Pro Gly Gly Pro Gln Glu Glu
            260                 265                 270         
Gly Asp Gly Val Pro Cys Thr Pro Ala Ser Ala Pro Thr Ser Gly Pro
        275                 280                 285             
Ala Pro Gly Leu Gly Pro Ala Ser Trp Cys Leu Glu Pro Gly Ser Val
    290                 295                 300                 
Ala Gln Gly Ser Pro Asp Pro Gln Gln Thr Pro Ser Arg Met Gly Arg
305                 310                 315                 320 
Glu Gly Glu Gly Thr His Ser Ser Leu Gly Cys Ser Ser Leu Gly Met
                325                 330                 335     
Val Val Ile Ala Asp Leu Ser Thr Asp Pro Thr Glu Leu Glu Glu Arg
            340                 345                 350         
Ala Leu Glu Val Ala Gly Pro Asp Gly Gln Ala Ser Ala Ile Ser Pro
        355                 360                 365             
Ala Ser Pro Arg Arg Lys Ala Ala Asp Gly Gly His Arg Arg Ala Leu
    370                 375                 380                 
Pro Gly Cys Thr Ser Leu Thr Gly Glu Thr Thr Gly Glu Ser Gly Glu
385                 390                 395                 400 
Ala Gly Gln Asp Gly Lys Pro Pro Gly Asp Val Leu Val Gly Pro Thr
                405                 410                 415     
Ala Ser Leu Ala Leu Ala Pro Gly Ser Gly Glu Ser Met Met Gly Ala
            420                 425                 430         
Gly Asp Ser Gly His Ala Ser Pro Asp Thr Gly Pro Cys Val Asn Gln
        435                 440                 445             
Lys Gln Glu Pro Gly Pro Ala Gln Glu Glu Ala Glu Leu Gly Gly Gln
    450                 455                 460                 
Asn Leu Glu Arg Asp Leu Glu Gly Phe Arg Val Ser Pro Gln Ala Ser
465                 470                 475                 480 
Val Val Leu Glu His Arg Glu Ile Ala Asp Asp Pro Leu Gln Glu Pro
                485                 490                 495     
Gly Ala Gln Gln Gly Ile Pro Asp Thr Thr Ser Glu Leu Ala Gly Gln
            500                 505                 510         
Arg Asp His Leu Pro His Ser Ala Asp Gln Gly Thr Trp Ala Asp Ser
        515                 520                 525             
Leu Ala Val Glu Leu Asp Phe Leu Leu Asp Ser Gln Ile Gln Asp Ala
    530                 535                 540                 
Leu Asp Ala Ser Asp Phe Glu Ala Pro Pro Glu Gln Leu Phe Pro Ser
545                 550                 555                 560 
Gly Asn Lys Pro Gly Pro Cys Trp Pro Gly Pro Ser Ser His Ala Asn
                565                 570                 575     
Gly Asp Pro Val Ala Val Ala Lys Ala Gln Pro Ser Arg Leu Ile Met
            580                 585                 590         
Gly Thr His Arg Asp Leu Glu Ala Phe Lys Arg Leu Asn Tyr Arg Lys
        595                 600                 605             
Thr Lys Leu Gly Gly Lys Ala Pro Leu Pro Tyr Pro Ser Lys Gly Pro
    610                 615                 620                 
Gly Asn Ile Pro Arg Gly Asp Pro Pro Trp Arg Glu Leu
625                 630                 635         


<210> 129
<211> 553
<212> PRT
<213> Homo sapiens

<400> 129
Met Ala Ala Pro Ala Gly Gly Gly Gly Ser Ala Val Ser Val Leu Ala
 1               5                  10                  15      
Pro Asn Gly Arg Arg His Thr Val Lys Val Thr Pro Ser Thr Val Leu
            20                  25                  30          
Leu Gln Val Leu Glu Asp Thr Cys Arg Arg Gln Asp Phe Asn Pro Cys
        35                  40                  45              
Glu Tyr Asp Leu Lys Phe Gln Arg Ser Val Leu Asp Leu Ser Leu Gln
    50                  55                  60                  
Trp Arg Phe Ala Asn Leu Pro Asn Asn Ala Lys Leu Glu Met Val Pro
65                  70                  75                  80  
Ala Ser Arg Ser Arg Glu Gly Pro Glu Asn Met Val Arg Ile Ala Leu
                85                  90                  95      
Gln Leu Asp Asp Gly Ser Arg Leu Gln Asp Ser Phe Cys Ser Gly Gln
            100                 105                 110         
Thr Leu Trp Glu Leu Leu Ser His Phe Pro Gln Ile Arg Glu Cys Leu
        115                 120                 125             
Gln His Pro Gly Gly Ala Thr Pro Val Cys Val Tyr Thr Arg Asp Glu
    130                 135                 140                 
Val Thr Gly Glu Ala Ala Leu Arg Gly Thr Thr Leu Gln Ser Leu Gly
145                 150                 155                 160 
Leu Thr Gly Gly Ser Ala Thr Ile Arg Phe Val Met Lys Cys Tyr Asp
                165                 170                 175     
Pro Val Gly Lys Thr Pro Gly Ser Leu Gly Ser Ser Ala Ser Ala Gly
            180                 185                 190         
Gln Ala Ala Ala Ser Ala Pro Leu Pro Leu Glu Ser Gly Glu Leu Ser
        195                 200                 205             
Arg Gly Asp Leu Ser Arg Pro Glu Asp Ala Asp Thr Ser Gly Pro Cys
    210                 215                 220                 
Cys Glu His Thr Gln Glu Lys Gln Ser Thr Arg Ala Pro Ala Ala Ala
225                 230                 235                 240 
Pro Phe Val Pro Phe Ser Gly Gly Gly Gln Arg Gln Gly Gly Pro Pro
                245                 250                 255     
Gly Pro Thr Arg Pro Leu Thr Ser Ser Ser Ala Lys Leu Pro Lys Ser
            260                 265                 270         
Leu Ser Ser Pro Gly Gly Pro Ser Lys Pro Lys Lys Ser Lys Ser Gly
        275                 280                 285             
Gln Asp Pro Gln Gln Glu Gln Glu Gln Glu Arg Glu Arg Asp Pro Gln
    290                 295                 300                 
Gln Glu Gln Glu Arg Glu Arg Pro Val Asp Arg Glu Pro Val Asp Arg
305                 310                 315                 320 
Glu Pro Val Val Cys His Pro Asp Leu Glu Glu Arg Leu Gln Ala Trp
                325                 330                 335     
Pro Ala Glu Leu Pro Asp Glu Phe Phe Glu Leu Thr Val Asp Asp Val
            340                 345                 350         
Arg Arg Arg Leu Ala Gln Leu Lys Ser Glu Arg Lys Arg Leu Glu Glu
        355                 360                 365             
Ala Pro Leu Val Thr Lys Ala Phe Arg Glu Ala Gln Ile Lys Glu Lys
    370                 375                 380                 
Leu Glu Arg Tyr Pro Lys Val Ala Leu Arg Val Leu Phe Pro Asp Arg
385                 390                 395                 400 
Tyr Val Leu Gln Gly Phe Phe Arg Pro Ser Glu Thr Val Gly Asp Leu
                405                 410                 415     
Arg Asp Phe Val Arg Ser His Leu Gly Asn Pro Glu Leu Ser Phe Tyr
            420                 425                 430         
Leu Phe Ile Thr Pro Pro Lys Thr Val Leu Asp Asp His Thr Gln Thr
        435                 440                 445             
Leu Phe Gln Ala Asn Leu Phe Pro Ala Ala Leu Val His Leu Gly Ala
    450                 455                 460                 
Glu Glu Pro Ala Gly Val Tyr Leu Glu Pro Gly Leu Leu Glu His Ala
465                 470                 475                 480 
Ile Ser Pro Ser Ala Ala Asp Val Leu Val Ala Arg Tyr Met Ser Arg
                485                 490                 495     
Ala Ala Gly Ser Pro Ser Pro Leu Pro Ala Pro Asp Pro Ala Pro Lys
            500                 505                 510         
Ser Glu Pro Ala Ala Glu Glu Gly Ala Leu Val Pro Pro Glu Pro Ile
        515                 520                 525             
Pro Gly Thr Ala Gln Pro Val Lys Arg Ser Leu Gly Lys Val Pro Lys
    530                 535                 540                 
Trp Leu Lys Leu Pro Ala Ser Lys Arg
545                 550             


<210> 130
<211> 553
<212> PRT
<213> Homo sapiens

<400> 130
Met Ala Ala Pro Ala Gly Gly Gly Gly Ser Ala Val Ser Val Leu Ala
 1               5                  10                  15      
Pro Asn Gly Arg Arg His Thr Val Lys Val Thr Pro Ser Thr Val Leu
            20                  25                  30          
Leu Gln Val Leu Glu Asp Thr Cys Arg Arg Gln Asp Phe Asn Pro Cys
        35                  40                  45              
Glu Tyr Asp Leu Lys Phe Gln Arg Ser Val Leu Asp Leu Ser Leu Gln
    50                  55                  60                  
Trp Arg Phe Ala Asn Leu Pro Asn Asn Ala Lys Leu Glu Met Val Pro
65                  70                  75                  80  
Ala Ser Arg Ser Arg Glu Gly Pro Glu Asn Met Val Arg Ile Ala Leu
                85                  90                  95      
Gln Leu Asp Asp Gly Ser Arg Leu Gln Asp Ser Phe Cys Ser Gly Gln
            100                 105                 110         
Thr Leu Trp Glu Leu Leu Ser His Phe Pro Gln Ile Arg Glu Cys Leu
        115                 120                 125             
Gln His Pro Gly Gly Ala Thr Pro Val Cys Val Tyr Thr Arg Asp Glu
    130                 135                 140                 
Val Thr Gly Glu Ala Ala Leu Arg Gly Thr Thr Leu Gln Ser Leu Gly
145                 150                 155                 160 
Leu Thr Gly Gly Ser Ala Thr Ile Arg Phe Val Met Lys Cys Tyr Asp
                165                 170                 175     
Pro Val Gly Lys Thr Pro Gly Ser Leu Gly Ser Ser Ala Ser Ala Gly
            180                 185                 190         
Gln Ala Ala Ala Ser Ala Pro Leu Pro Leu Glu Ser Gly Glu Leu Ser
        195                 200                 205             
Arg Gly Asp Leu Ser Arg Pro Glu Asp Ala Asp Thr Ser Gly Pro Cys
    210                 215                 220                 
Cys Glu His Thr Gln Glu Lys Gln Ser Thr Arg Ala Pro Ala Ala Ala
225                 230                 235                 240 
Pro Phe Val Pro Phe Ser Gly Gly Gly Gln Arg Leu Gly Gly Pro Pro
                245                 250                 255     
Gly Pro Thr Arg Pro Leu Thr Ser Ser Ser Ala Lys Leu Pro Lys Ser
            260                 265                 270         
Leu Ser Ser Pro Gly Gly Pro Ser Lys Pro Lys Lys Ser Lys Ser Gly
        275                 280                 285             
Gln Asp Pro Gln Gln Glu Gln Glu Gln Glu Arg Glu Arg Asp Pro Gln
    290                 295                 300                 
Gln Glu Gln Glu Arg Glu Arg Pro Val Asp Arg Glu Pro Val Asp Arg
305                 310                 315                 320 
Glu Pro Val Val Cys His Pro Asp Leu Glu Glu Arg Leu Gln Ala Trp
                325                 330                 335     
Pro Ala Glu Leu Pro Asp Glu Phe Phe Glu Leu Thr Val Asp Asp Val
            340                 345                 350         
Arg Arg Arg Leu Ala Gln Leu Lys Ser Glu Arg Lys Arg Leu Glu Glu
        355                 360                 365             
Ala Pro Leu Val Thr Lys Ala Phe Arg Glu Ala Gln Ile Lys Glu Lys
    370                 375                 380                 
Leu Glu Arg Tyr Pro Lys Val Ala Leu Arg Val Leu Phe Pro Asp Arg
385                 390                 395                 400 
Tyr Val Leu Gln Gly Phe Phe Arg Pro Ser Glu Thr Val Gly Asp Leu
                405                 410                 415     
Arg Asp Phe Val Arg Ser His Leu Gly Asn Pro Glu Leu Ser Phe Tyr
            420                 425                 430         
Leu Phe Ile Thr Pro Pro Lys Thr Val Leu Asp Asp His Thr Gln Thr
        435                 440                 445             
Leu Phe Gln Ala Asn Leu Phe Pro Ala Ala Leu Val His Leu Gly Ala
    450                 455                 460                 
Glu Glu Pro Ala Gly Val Tyr Leu Glu Pro Gly Leu Leu Glu His Ala
465                 470                 475                 480 
Ile Ser Pro Ser Ala Ala Asp Val Leu Val Ala Arg Tyr Met Ser Arg
                485                 490                 495     
Ala Ala Gly Ser Pro Ser Pro Leu Pro Ala Pro Asp Pro Ala Pro Lys
            500                 505                 510         
Ser Glu Pro Ala Ala Glu Glu Gly Ala Leu Val Pro Pro Glu Pro Ile
        515                 520                 525             
Pro Gly Thr Ala Gln Pro Val Lys Arg Ser Leu Gly Lys Val Pro Lys
    530                 535                 540                 
Trp Leu Lys Leu Pro Ala Ser Lys Arg
545                 550             


<210> 131
<211> 483
<212> PRT
<213> Homo sapiens

<400> 131
Met Ser Gly Gly Gly Pro Ser Gly Gly Gly Pro Gly Gly Ser Gly Arg
 1               5                  10                  15      
Ala Arg Thr Ser Ser Phe Ala Glu Pro Gly Gly Gly Gly Gly Gly Gly
            20                  25                  30          
Gly Gly Gly Pro Gly Gly Ser Ala Ser Gly Pro Gly Gly Thr Gly Gly
        35                  40                  45              
Gly Lys Ala Ser Val Gly Ala Met Gly Gly Gly Val Gly Ala Ser Ser
    50                  55                  60                  
Ser Gly Gly Gly Pro Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Pro
65                  70                  75                  80  
Gly Ala Gly Thr Ser Phe Pro Pro Pro Gly Val Lys Leu Gly Arg Asp
                85                  90                  95      
Ser Gly Lys Val Thr Thr Val Val Ala Thr Leu Gly Gln Gly Pro Glu
            100                 105                 110         
Arg Ser Gln Glu Val Ala Tyr Thr Asp Ile Lys Val Ile Gly Asn Gly
        115                 120                 125             
Ser Phe Gly Val Val Tyr Gln Ala Arg Leu Ala Glu Thr Arg Glu Leu
    130                 135                 140                 
Val Ala Ile Lys Lys Val Leu Gln Asp Lys Arg Phe Lys Asn Arg Glu
145                 150                 155                 160 
Leu Gln Ile Met Arg Lys Leu Asp His Cys Asn Ile Val Arg Leu Arg
                165                 170                 175     
Tyr Phe Phe Tyr Ser Ser Gly Glu Lys Lys Asp Glu Leu Tyr Leu Asn
            180                 185                 190         
Leu Val Leu Glu Tyr Val Pro Glu Thr Val Tyr Arg Val Ala Arg His
        195                 200                 205             
Phe Thr Lys Ala Lys Leu Thr Ile Pro Ile Leu Tyr Val Lys Val Tyr
    210                 215                 220                 
Met Tyr Gln Leu Phe Arg Ser Leu Ala Tyr Ile His Ser Gln Gly Val
225                 230                 235                 240 
Cys His Arg Asp Ile Lys Pro Gln Asn Leu Leu Val Asp Pro Asp Thr
                245                 250                 255     
Ala Val Leu Lys Leu Cys Asp Phe Gly Ser Ala Lys Gln Leu Val Arg
            260                 265                 270         
Gly Glu Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala Pro
        275                 280                 285             
Glu Leu Ile Phe Gly Ala Thr Asp Tyr Thr Ser Ser Ile Asp Val Trp
    290                 295                 300                 
Ser Ala Gly Cys Val Leu Ala Glu Leu Leu Leu Gly Gln Pro Ile Phe
305                 310                 315                 320 
Pro Gly Asp Ser Gly Val Asp Gln Leu Val Glu Ile Ile Lys Val Leu
                325                 330                 335     
Gly Thr Pro Thr Arg Glu Gln Ile Arg Glu Met Asn Pro Asn Tyr Thr
            340                 345                 350         
Glu Phe Lys Phe Pro Gln Ile Lys Ala His Pro Trp Thr Lys Val Phe
        355                 360                 365             
Lys Ser Arg Thr Pro Pro Glu Ala Ile Ala Leu Cys Ser Ser Leu Leu
    370                 375                 380                 
Glu Tyr Thr Pro Ser Ser Arg Leu Ser Pro Leu Glu Ala Cys Ala His
385                 390                 395                 400 
Ser Phe Phe Asp Glu Leu Arg Cys Leu Gly Thr Gln Leu Pro Asn Asn
                405                 410                 415     
Arg Pro Leu Pro Pro Leu Phe Asn Phe Ser Ala Gly Glu Leu Ser Ile
            420                 425                 430         
Gln Pro Ser Leu Asn Ala Ile Leu Ile Pro Pro His Leu Arg Ser Pro
        435                 440                 445             
Ala Gly Thr Thr Thr Leu Thr Pro Ser Ser Gln Ala Leu Thr Glu Thr
    450                 455                 460                 
Pro Thr Ser Ser Asp Trp Gln Ser Thr Asp Ala Thr Pro Thr Leu Thr
465                 470                 475                 480 
Asn Ser Ser
            


<210> 132
<211> 744
<212> PRT
<213> Homo sapiens

<400> 132
Met Glu Gln Asp Pro Lys Pro Pro Arg Leu Arg Leu Trp Ala Leu Ile
 1               5                  10                  15      
Pro Trp Leu Pro Arg Lys Gln Arg Pro Arg Ile Ser Gln Thr Ser Leu
            20                  25                  30          
Pro Val Pro Gly Pro Gly Ser Gly Pro Gln Arg Asp Ser Asp Glu Gly
        35                  40                  45              
Val Leu Lys Glu Ile Ser Ile Thr His His Val Lys Ala Gly Ser Glu
    50                  55                  60                  
Lys Ala Asp Pro Ser His Phe Glu Leu Leu Lys Val Leu Gly Gln Gly
65                  70                  75                  80  
Ser Phe Gly Lys Val Phe Leu Val Arg Lys Val Thr Arg Pro Asp Ser
                85                  90                  95      
Gly His Leu Tyr Ala Met Lys Val Leu Lys Lys Ala Thr Leu Lys Val
            100                 105                 110         
Arg Asp Arg Val Arg Thr Lys Met Glu Arg Asp Ile Leu Ala Asp Val
        115                 120                 125             
Asn His Pro Phe Val Val Lys Leu His Tyr Ala Phe Gln Thr Glu Gly
    130                 135                 140                 
Lys Leu Tyr Leu Ile Leu Asp Phe Leu Arg Gly Gly Asp Leu Phe Thr
145                 150                 155                 160 
Arg Leu Ser Lys Glu Val Met Phe Thr Glu Glu Asp Val Lys Phe Tyr
                165                 170                 175     
Leu Ala Glu Leu Ala Leu Gly Leu Asp His Leu His Ser Leu Gly Ile
            180                 185                 190         
Ile Tyr Arg Asp Leu Lys Pro Glu Asn Ile Leu Leu Asp Glu Glu Gly
        195                 200                 205             
His Ile Lys Leu Thr Asp Phe Gly Leu Ser Lys Glu Ala Ile Asp His
    210                 215                 220                 
Glu Lys Lys Ala Tyr Ser Phe Cys Gly Thr Val Glu Tyr Met Ala Pro
225                 230                 235                 240 
Glu Val Val Asn Arg Gln Gly His Ser His Ser Ala Asp Trp Trp Ser
                245                 250                 255     
Tyr Gly Val Leu Met Phe Glu Met Leu Thr Gly Ser Leu Pro Phe Gln
            260                 265                 270         
Gly Lys Asp Arg Lys Glu Thr Met Thr Leu Ile Leu Lys Ala Lys Leu
        275                 280                 285             
Gly Met Pro Gln Phe Leu Ser Thr Glu Ala Gln Ser Leu Leu Arg Ala
    290                 295                 300                 
Leu Phe Lys Arg Asn Pro Ala Asn Arg Leu Gly Ser Gly Pro Asp Gly
305                 310                 315                 320 
Ala Glu Glu Ile Lys Arg His Val Phe Tyr Ser Thr Ile Asp Trp Asn
                325                 330                 335     
Lys Leu Tyr Arg Arg Glu Ile Lys Pro Pro Phe Lys Pro Ala Val Ala
            340                 345                 350         
Gln Pro Asp Asp Thr Phe Tyr Phe Asp Thr Glu Phe Thr Ser Arg Thr
        355                 360                 365             
Pro Lys Asp Ser Pro Gly Ile Pro Pro Ser Ala Gly Ala His Gln Leu
    370                 375                 380                 
Phe Arg Gly Phe Ser Phe Val Ala Thr Gly Leu Met Glu Asp Asp Gly
385                 390                 395                 400 
Lys Pro Arg Ala Pro Gln Ala Pro Leu His Ser Val Val Gln Gln Leu
                405                 410                 415     
His Gly Lys Asn Leu Val Phe Ser Asp Gly Tyr Val Val Lys Glu Thr
            420                 425                 430         
Ile Gly Val Gly Ser Tyr Ser Glu Cys Lys Arg Cys Val His Lys Ala
        435                 440                 445             
Thr Asn Met Glu Tyr Ala Val Lys Val Ile Asp Lys Ser Lys Arg Asp
    450                 455                 460                 
Pro Ser Glu Glu Ile Glu Ile Leu Leu Arg Tyr Gly Gln His Pro Asn
465                 470                 475                 480 
Ile Ile Thr Leu Lys Asp Val Tyr Asp Asp Gly Lys His Val Tyr Leu
                485                 490                 495     
Val Thr Glu Leu Met Arg Gly Gly Glu Leu Leu Asp Lys Ile Leu Arg
            500                 505                 510         
Gln Lys Phe Phe Ser Glu Arg Glu Ala Ser Phe Val Leu His Thr Ile
        515                 520                 525             
Gly Lys Thr Val Glu Tyr Leu His Ser Gln Gly Val Val His Arg Asp
    530                 535                 540                 
Leu Lys Pro Ser Asn Ile Leu Tyr Val Asp Glu Ser Gly Asn Pro Glu
545                 550                 555                 560 
Cys Leu Arg Ile Cys Asp Phe Gly Phe Ala Lys Gln Leu Arg Ala Glu
                565                 570                 575     
Asn Gly Leu Leu Met Thr Pro Cys Tyr Thr Ala Asn Phe Val Ala Pro
            580                 585                 590         
Glu Val Leu Lys Arg Gln Gly Tyr Asp Glu Gly Cys Asp Ile Trp Ser
        595                 600                 605             
Leu Gly Ile Leu Leu Tyr Thr Met Leu Ala Gly Tyr Thr Pro Phe Ala
    610                 615                 620                 
Asn Gly Pro Ser Asp Thr Pro Glu Glu Ile Leu Thr Arg Ile Gly Ser
625                 630                 635                 640 
Gly Lys Phe Thr Leu Ser Gly Gly Asn Trp Asn Thr Val Ser Glu Thr
                645                 650                 655     
Ala Lys Asp Leu Val Ser Lys Met Leu His Val Asp Pro His Gln Arg
            660                 665                 670         
Leu Thr Ala Lys Gln Val Leu Gln His Pro Trp Val Thr Gln Lys Asp
        675                 680                 685             
Lys Leu Pro Gln Ser Gln Leu Ser His Gln Asp Leu Gln Leu Val Lys
    690                 695                 700                 
Gly Ala Met Ala Ala Thr Tyr Ser Ala Leu Asn Ser Ser Lys Pro Thr
705                 710                 715                 720 
Pro Gln Leu Lys Pro Ile Glu Ser Ser Ile Leu Ala Gln Arg Arg Val
                725                 730                 735     
Arg Lys Leu Pro Ser Thr Thr Leu
            740                 


<210> 133
<211> 209
<212> PRT
<213> Homo sapiens

<400> 133
Met Asp Ser Asp Glu Thr Gly Phe Glu His Ser Gly Leu Trp Val Ser
 1               5                  10                  15      
Val Leu Ala Gly Leu Leu Leu Gly Ala Cys Gln Ala His Pro Ile Pro
            20                  25                  30          
Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr
        35                  40                  45              
Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg
    50                  55                  60                  
Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu
65                  70                  75                  80  
Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val
                85                  90                  95      
Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly
            100                 105                 110         
Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu
        115                 120                 125             
Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu
    130                 135                 140                 
His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly
145                 150                 155                 160 
Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu
                165                 170                 175     
Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp
            180                 185                 190         
Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala
        195                 200                 205             
Ser
    


<210> 134
<211> 151
<212> PRT
<213> Homo sapiens

<400> 134
Met Asp Ser Ala Ala Cys Ala Ala Ala Ala Thr Pro Val Pro Ala Leu
 1               5                  10                  15      
Ala Leu Ala Leu Ala Pro Asp Leu Ala Gln Ala Pro Leu Ala Leu Pro
            20                  25                  30          
Gly Leu Leu Ser Pro Ser Cys Leu Leu Ser Ser Gly Gln Glu Val Asn
        35                  40                  45              
Gly Ser Glu Arg Gly Thr Cys Leu Trp Arg Pro Trp Leu Ser Ser Thr
    50                  55                  60                  
Asn Asp Ser Pro Arg Gln Met Arg Lys Leu Val Asp Leu Ala Ala Gly
65                  70                  75                  80  
Gly Ala Thr Ala Ala Glu Val Thr Lys Ala Glu Ser Lys Phe His His
                85                  90                  95      
Pro Val Arg Leu Phe Trp Pro Lys Ser Arg Ser Phe Asp Tyr Leu Tyr
            100                 105                 110         
Ser Ala Gly Glu Ile Leu Leu Gln Asn Phe Pro Val Gln Ala Thr Ile
        115                 120                 125             
Asn Leu Tyr Glu Asp Ser Asp Ser Glu Glu Glu Glu Glu Asp Glu Glu
    130                 135                 140                 
Gln Glu Asp Glu Glu Glu Lys
145                 150     


<210> 135
<211> 539
<212> PRT
<213> Homo sapiens

<400> 135
Met Trp Arg Leu Pro Arg Ala Leu Cys Val His Ala Ala Lys Thr Ser
 1               5                  10                  15      
Lys Leu Ser Gly Pro Trp Ser Arg Pro Ala Ala Phe Met Ser Thr Leu
            20                  25                  30          
Leu Ile Asn Gln Pro Gln Tyr Ala Trp Leu Lys Glu Leu Gly Leu Arg
        35                  40                  45              
Glu Glu Asn Glu Gly Val Tyr Asn Gly Ser Trp Gly Gly Arg Gly Glu
    50                  55                  60                  
Val Ile Thr Thr Tyr Cys Pro Ala Asn Asn Glu Pro Ile Ala Arg Val
65                  70                  75                  80  
Arg Gln Ala Ser Val Ala Asp Tyr Glu Glu Thr Val Lys Lys Ala Arg
                85                  90                  95      
Glu Ala Trp Lys Ile Trp Ala Asp Ile Pro Ala Pro Lys Arg Gly Glu
            100                 105                 110         
Ile Val Arg Gln Ile Gly Asp Ala Leu Arg Glu Lys Ile Gln Val Leu
        115                 120                 125             
Gly Ser Leu Val Ser Leu Glu Met Gly Lys Ile Leu Val Glu Gly Val
    130                 135                 140                 
Gly Glu Val Gln Glu Tyr Val Asp Ile Cys Asp Tyr Ala Val Gly Leu
145                 150                 155                 160 
Ser Arg Met Ile Gly Gly Pro Ile Leu Pro Ser Glu Arg Ser Gly His
                165                 170                 175     
Ala Leu Ile Glu Gln Trp Asn Pro Val Gly Leu Val Gly Ile Ile Thr
            180                 185                 190         
Ala Phe Asn Phe Pro Val Ala Val Tyr Gly Trp Asn Asn Ala Ile Ala
        195                 200                 205             
Met Ile Cys Gly Asn Val Cys Leu Trp Lys Gly Ala Pro Thr Thr Ser
    210                 215                 220                 
Leu Ile Ser Val Ala Val Thr Lys Ile Ile Ala Lys Val Leu Glu Asp
225                 230                 235                 240 
Asn Lys Leu Pro Gly Ala Ile Cys Ser Leu Thr Cys Gly Gly Ala Asp
                245                 250                 255     
Ile Gly Thr Ala Met Ala Lys Asp Glu Arg Val Asn Leu Leu Ser Phe
            260                 265                 270         
Thr Gly Ser Thr Gln Val Gly Lys Gln Val Gly Leu Met Val Gln Glu
        275                 280                 285             
Arg Phe Gly Arg Ser Leu Leu Glu Leu Gly Gly Asn Asn Ala Ile Ile
    290                 295                 300                 
Ala Phe Glu Asp Ala Asp Leu Ser Leu Val Val Pro Ser Ala Leu Phe
305                 310                 315                 320 
Ala Ala Val Gly Thr Ala Gly Gln Arg Cys Thr Thr Ala Arg Arg Leu
                325                 330                 335     
Phe Ile His Glu Ser Ile His Asp Glu Val Val Asn Arg Leu Lys Lys
            340                 345                 350         
Ala Tyr Ala Gln Ile Arg Val Gly Asn Pro Trp Asp Pro Asn Val Leu
        355                 360                 365             
Tyr Gly Pro Leu His Thr Lys Gln Ala Val Ser Met Phe Leu Gly Ala
    370                 375                 380                 
Val Glu Glu Ala Lys Lys Glu Gly Gly Thr Val Val Tyr Gly Gly Lys
385                 390                 395                 400 
Val Met Asp Arg Pro Gly Asn Tyr Val Glu Pro Thr Ile Val Thr Gly
                405                 410                 415     
Leu Gly His Asp Ala Ser Ile Ala His Thr Glu Thr Phe Ala Pro Ile
            420                 425                 430         
Leu Tyr Val Phe Lys Phe Lys Asn Glu Glu Glu Val Phe Ala Trp Asn
        435                 440                 445             
Asn Glu Val Lys Gln Gly Leu Ser Ser Ser Ile Phe Thr Lys Asp Leu
    450                 455                 460                 
Gly Arg Ile Phe Arg Trp Leu Gly Pro Lys Gly Ser Asp Cys Gly Ile
465                 470                 475                 480 
Val Asn Val Asn Ile Pro Thr Ser Gly Ala Glu Ile Gly Gly Ala Phe
                485                 490                 495     
Gly Gly Glu Lys His Thr Gly Gly Gly Arg Glu Ser Gly Ser Asp Ala
            500                 505                 510         
Trp Lys Gln Tyr Met Arg Arg Ser Thr Cys Thr Ile Asn Tyr Ser Lys
        515                 520                 525             
Asp Leu Pro Leu Ala Gln Gly Ile Lys Phe Gln
    530                 535                 


<210> 136
<211> 280
<212> PRT
<213> Homo sapiens

<400> 136
Met Ala Thr Glu Ala Pro Val Asn Ile Ala Pro Pro Glu Cys Ser Thr
 1               5                  10                  15      
Val Val Ser Thr Ala Val Asp Ser Leu Ile Trp Gln Pro Asn Ser Leu
            20                  25                  30          
Asn Met His Met Ile Arg Pro Lys Ser Ala Lys Gly Arg Thr Arg Pro
        35                  40                  45              
Ser Leu Gln Lys Ser Gln Gly Val Glu Val Cys Ala His His Ile Pro
    50                  55                  60                  
Ser Pro Pro Pro Ala Ile Pro Tyr Glu Leu Pro Ser Ser Gln Lys Pro
65                  70                  75                  80  
Gly Ala Cys Ala Pro Lys Ser Pro Asn Gln Gly Ala Ser Asp Glu Ile
                85                  90                  95      
Pro Glu Leu Gln Gln Gln Val Pro Thr Gly Ala Ser Ser Ser Leu Asn
            100                 105                 110         
Lys Tyr Pro Val Leu Pro Ser Ile Asn Arg Lys Asn Leu Glu Glu Glu
        115                 120                 125             
Ala Val Glu Thr Val Ala Lys Lys Ala Ser Ser Leu Gln Leu Ser Ser
    130                 135                 140                 
Ile Arg Ala Leu Tyr Gln Asp Glu Thr Gly Thr Met Lys Thr Ser Glu
145                 150                 155                 160 
Glu Asp Ser Arg Ala Arg Ala Cys Ala Val Glu Arg Lys Phe Ile Val
                165                 170                 175     
Arg Thr Lys Lys Gln Gly Ser Ser Arg Ala Gly Asn Leu Glu Glu Pro
            180                 185                 190         
Ser Asp Gln Glu Pro Arg Leu Leu Leu Ala Val Arg Ser Pro Thr Gly
        195                 200                 205             
Gln Arg Phe Val Arg His Phe Arg Pro Thr Asp Asp Leu Gln Thr Ile
    210                 215                 220                 
Val Ala Val Ala Glu Gln Lys Asn Lys Thr Ser Tyr Arg His Cys Ser
225                 230                 235                 240 
Ile Glu Thr Met Glu Val Pro Arg Arg Arg Phe Ser Asp Leu Thr Lys
                245                 250                 255     
Ser Leu Gln Glu Cys Arg Ile Pro His Lys Ser Val Leu Gly Ile Ser
            260                 265                 270         
Leu Glu Asp Gly Glu Gly Trp Pro
        275                 280 


<210> 137
<211> 666
<212> PRT
<213> Homo sapiens

<400> 137
Met Ala Thr Thr Val Thr Cys Thr Arg Phe Thr Asp Glu Tyr Gln Leu
 1               5                  10                  15      
Tyr Glu Asp Ile Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val
            20                  25                  30          
Lys Leu Cys Thr Gly His Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys
        35                  40                  45              
Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile
    50                  55                  60                  
Cys Arg Leu Leu Lys His Ser Asn Ile Val Arg Leu His Asp Ser Ile
65                  70                  75                  80  
Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly
                85                  90                  95      
Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp
            100                 105                 110         
Ala Ser His Cys Ile Gln Gln Ile Leu Glu Ala Val Leu His Cys His
        115                 120                 125             
Gln Met Gly Val Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu
    130                 135                 140                 
Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu
145                 150                 155                 160 
Ala Ile Glu Val Gln Gly Asp Gln Gln Ala Trp Phe Gly Phe Ala Gly
                165                 170                 175     
Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Glu Ala Tyr Gly
            180                 185                 190         
Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu
        195                 200                 205             
Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln
    210                 215                 220                 
Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr
225                 230                 235                 240 
Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn
                245                 250                 255     
Pro Ala Lys Arg Ile Thr Ala His Glu Ala Leu Lys His Pro Trp Val
            260                 265                 270         
Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val
        275                 280                 285             
Glu Cys Leu Lys Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile
    290                 295                 300                 
Leu Thr Thr Met Leu Ala Thr Arg Asn Phe Ser Val Gly Arg Gln Thr
305                 310                 315                 320 
Thr Ala Pro Ala Thr Met Ser Thr Ala Ala Ser Gly Thr Thr Met Gly
                325                 330                 335     
Leu Val Glu Gln Ala Lys Ser Leu Leu Asn Lys Lys Ala Asp Gly Val
            340                 345                 350         
Lys Pro Gln Thr Asn Ser Thr Lys Asn Ser Ala Ala Ala Thr Ser Pro
        355                 360                 365             
Lys Gly Thr Leu Pro Pro Ala Ala Leu Glu Pro Gln Thr Thr Val Ile
    370                 375                 380                 
His Asn Pro Val Asp Gly Ile Lys Glu Ser Ser Asp Ser Ala Asn Thr
385                 390                 395                 400 
Thr Ile Glu Asp Glu Asp Ala Lys Ala Pro Arg Val Pro Asp Ile Leu
                405                 410                 415     
Ser Ser Val Arg Arg Gly Ser Gly Ala Pro Glu Ala Glu Gly Pro Leu
            420                 425                 430         
Pro Cys Pro Ser Pro Ala Pro Phe Ser Pro Leu Pro Ala Pro Ser Pro
        435                 440                 445             
Arg Ile Ser Asp Ile Leu Asn Ser Val Arg Arg Gly Ser Gly Thr Pro
    450                 455                 460                 
Glu Ala Glu Gly Pro Leu Ser Ala Gly Pro Pro Pro Cys Leu Ser Pro
465                 470                 475                 480 
Ala Leu Leu Gly Pro Leu Ser Ser Pro Ser Pro Arg Ile Ser Asp Ile
                485                 490                 495     
Leu Asn Ser Val Arg Arg Gly Ser Gly Thr Pro Glu Ala Glu Gly Pro
            500                 505                 510         
Ser Pro Val Gly Pro Pro Pro Cys Pro Ser Pro Thr Ile Pro Gly Pro
        515                 520                 525             
Leu Pro Thr Pro Ser Arg Lys Gln Glu Ile Ile Lys Thr Thr Glu Gln
    530                 535                 540                 
Leu Ile Glu Ala Val Asn Asn Gly Asp Phe Glu Ala Tyr Ala Lys Ile
545                 550                 555                 560 
Cys Asp Pro Gly Leu Thr Ser Phe Glu Pro Glu Ala Leu Gly Asn Leu
                565                 570                 575     
Val Glu Gly Met Asp Phe His Arg Phe Tyr Phe Glu Asn Leu Leu Ala
            580                 585                 590         
Lys Asn Ser Lys Pro Ile His Thr Thr Ile Leu Asn Pro His Val His
        595                 600                 605             
Val Ile Gly Glu Asp Ala Ala Cys Ile Ala Tyr Ile Arg Leu Thr Gln
    610                 615                 620                 
Tyr Ile Asp Gly Gln Gly Arg Pro Arg Thr Ser Gln Ser Glu Glu Thr
625                 630                 635                 640 
Arg Val Trp His Arg Arg Asp Gly Lys Trp Gln Asn Val His Phe His
                645                 650                 655     
Cys Ser Gly Ala Pro Val Ala Pro Leu Gln
            660                 665     


<210> 138
<211> 488
<212> PRT
<213> Homo sapiens

<400> 138
Met Arg Phe His Trp Leu Pro Thr Leu Ser Glu Pro Phe Asp Arg Asn
 1               5                  10                  15      
Gln Glu Leu Glu Thr Cys Ile Arg Pro Leu Trp Thr Pro Ser Gly Ser
            20                  25                  30          
Ala Cys Glu Thr Glu His Asn Lys Ser Met Asp Met Gly Asn Gln His
        35                  40                  45              
Pro Ser Ile Ser Arg Leu Gln Glu Ile Gln Lys Glu Val Lys Ser Val
    50                  55                  60                  
Glu Gln Gln Val Ile Gly Phe Ser Gly Leu Ser Asp Asp Lys Asn Tyr
65                  70                  75                  80  
Lys Lys Leu Glu Arg Ile Leu Thr Lys Gln Leu Phe Glu Ile Asp Ser
                85                  90                  95      
Val Asp Thr Glu Gly Lys Gly Asp Ile Gln Gln Ala Arg Lys Arg Ala
            100                 105                 110         
Ala Gln Glu Thr Glu Arg Leu Leu Lys Glu Leu Glu Gln Asn Ala Asn
        115                 120                 125             
His Pro His Arg Ile Glu Ile Gln Asn Ile Phe Glu Glu Ala Gln Ser
    130                 135                 140                 
Leu Val Arg Glu Lys Ile Val Pro Phe Tyr Asn Gly Gly Asn Cys Val
145                 150                 155                 160 
Thr Asp Glu Phe Glu Glu Gly Ile Gln Asp Ile Ile Leu Arg Leu Thr
                165                 170                 175     
His Val Lys Thr Gly Gly Lys Ile Ser Leu Arg Lys Ala Arg Tyr His
            180                 185                 190         
Thr Leu Thr Lys Ile Cys Ala Val Gln Glu Ile Ile Glu Asp Cys Met
        195                 200                 205             
Lys Lys Gln Pro Ser Leu Pro Leu Ser Glu Asp Ala His Pro Ser Val
    210                 215                 220                 
Ala Lys Ile Asn Phe Val Met Cys Glu Val Asn Lys Ala Arg Gly Val
225                 230                 235                 240 
Leu Ile Ala Leu Leu Met Gly Val Asn Asn Asn Glu Thr Cys Arg His
                245                 250                 255     
Leu Ser Cys Val Leu Ser Gly Leu Ile Ala Asp Leu Asp Ala Leu Asp
            260                 265                 270         
Val Cys Gly Arg Thr Glu Ile Arg Asn Tyr Arg Arg Glu Val Val Glu
        275                 280                 285             
Asp Ile Asn Lys Leu Leu Lys Tyr Leu Asp Leu Glu Glu Glu Ala Asp
    290                 295                 300                 
Thr Thr Lys Ala Phe Asp Leu Arg Gln Asn His Ser Ile Leu Lys Ile
305                 310                 315                 320 
Glu Lys Val Leu Lys Arg Met Arg Glu Ile Lys Asn Glu Leu Leu Gln
                325                 330                 335     
Ala Gln Asn Pro Ser Glu Leu Tyr Leu Ser Ser Lys Thr Glu Leu Gln
            340                 345                 350         
Gly Leu Ile Gly Gln Leu Asp Glu Val Ser Leu Glu Lys Asn Pro Cys
        355                 360                 365             
Ile Arg Glu Ala Arg Arg Arg Ala Val Ile Glu Val Gln Thr Leu Ile
    370                 375                 380                 
Thr Tyr Ile Asp Leu Lys Glu Ala Leu Glu Lys Arg Lys Leu Phe Ala
385                 390                 395                 400 
Cys Glu Glu His Pro Ser His Lys Ala Val Trp Asn Val Leu Gly Asn
                405                 410                 415     
Leu Ser Glu Ile Gln Gly Glu Val Leu Ser Phe Asp Gly Asn Arg Thr
            420                 425                 430         
Asp Lys Asn Tyr Ile Arg Leu Glu Glu Leu Leu Thr Lys Gln Leu Leu
        435                 440                 445             
Ala Leu Asp Ala Val Asp Pro Gln Gly Glu Glu Lys Cys Lys Ala Ala
    450                 455                 460                 
Arg Lys Gln Ala Val Arg Leu Ala Gln Asn Ile Leu Ser Tyr Leu Asp
465                 470                 475                 480 
Leu Lys Ser Asp Glu Trp Glu Tyr
                485             


<210> 139
<211> 928
<212> PRT
<213> Homo sapiens

<400> 139
Met Gly Gly Ser Ala Ser Ser Gln Leu Asp Glu Gly Lys Cys Ala Tyr
 1               5                  10                  15      
Ile Arg Gly Lys Thr Glu Ala Ala Ile Lys Asn Phe Ser Pro Tyr Tyr
            20                  25                  30          
Ser Arg Gln Tyr Ser Val Ala Phe Cys Asn His Val Arg Thr Glu Val
        35                  40                  45              
Glu Gln Gln Arg Asp Leu Thr Ser Gln Phe Leu Lys Thr Lys Pro Pro
    50                  55                  60                  
Leu Ala Pro Gly Thr Ile Leu Tyr Glu Ala Glu Leu Ser Gln Phe Ser
65                  70                  75                  80  
Glu Asp Ile Lys Lys Trp Lys Glu Arg Tyr Val Val Val Lys Asn Asp
                85                  90                  95      
Tyr Ala Val Glu Ser Tyr Glu Asn Lys Glu Ala Tyr Gln Arg Gly Ala
            100                 105                 110         
Ala Pro Lys Cys Arg Ile Leu Pro Ala Gly Gly Lys Val Leu Thr Ser
        115                 120                 125             
Glu Asp Glu Tyr Asn Leu Leu Ser Asp Arg His Phe Pro Asp Pro Leu
    130                 135                 140                 
Ala Ser Ser Glu Lys Glu Asn Thr Gln Pro Phe Val Val Leu Pro Lys
145                 150                 155                 160 
Glu Phe Pro Val Tyr Leu Trp Gln Pro Phe Phe Arg His Gly Tyr Phe
                165                 170                 175     
Cys Phe His Glu Ala Ala Asp Gln Lys Arg Phe Ser Ala Leu Leu Ser
            180                 185                 190         
Asp Cys Val Arg His Leu Asn His Asp Tyr Met Lys Gln Met Thr Phe
        195                 200                 205             
Glu Ala Gln Ala Phe Leu Glu Ala Val Gln Phe Phe Arg Gln Glu Lys
    210                 215                 220                 
Gly His Tyr Gly Ser Trp Glu Met Ile Thr Gly Asp Glu Ile Gln Ile
225                 230                 235                 240 
Leu Ser Asn Leu Val Met Glu Glu Leu Leu Pro Thr Leu Gln Thr Asp
                245                 250                 255     
Leu Leu Pro Lys Met Lys Gly Lys Lys Asn Asp Arg Lys Arg Thr Trp
            260                 265                 270         
Leu Gly Leu Leu Glu Glu Ala Tyr Thr Leu Val Gln His Gln Val Ser
        275                 280                 285             
Glu Gly Leu Ser Ala Leu Lys Glu Glu Cys Arg Ala Leu Thr Lys Gly
    290                 295                 300                 
Leu Glu Gly Thr Ile Arg Ser Asp Met Asp Gln Ile Val Asn Ser Lys
305                 310                 315                 320 
Asn Tyr Leu Ile Gly Lys Ile Lys Ala Met Val Ala Gln Pro Ala Glu
                325                 330                 335     
Lys Ser Cys Leu Glu Ser Val Gln Pro Phe Leu Ala Ser Ile Leu Glu
            340                 345                 350         
Glu Leu Met Gly Pro Val Ser Ser Gly Phe Ser Glu Val Arg Val Leu
        355                 360                 365             
Phe Glu Lys Glu Val Asn Glu Val Ser Gln Asn Phe Gln Thr Thr Lys
    370                 375                 380                 
Asp Ser Val Gln Leu Lys Glu His Leu Asp Arg Leu Met Asn Leu Pro
385                 390                 395                 400 
Leu His Ser Val Lys Met Glu Pro Cys Tyr Thr Lys Val Asn Leu Leu
                405                 410                 415     
His Glu Arg Leu Gln Asp Leu Lys Ser Arg Phe Arg Phe Pro His Ile
            420                 425                 430         
Asp Leu Val Val Gln Arg Thr Gln Asn Tyr Met Gln Glu Leu Met Glu
        435                 440                 445             
Asn Ala Val Phe Thr Phe Glu Gln Leu Leu Ser Pro His Leu Gln Gly
    450                 455                 460                 
Glu Ala Ser Lys Thr Ala Val Ala Ile Glu Lys Val Lys Leu Arg Val
465                 470                 475                 480 
Leu Lys Gln Tyr Asp Tyr Asp Ser Ser Thr Ile Arg Lys Lys Ile Phe
                485                 490                 495     
Gln Glu Ala Leu Val Gln Ile Thr Leu Pro Thr Val Gln Lys Ala Leu
            500                 505                 510         
Ala Ser Thr Cys Lys Pro Glu Leu Gln Lys Tyr Glu Gln Phe Ile Phe
        515                 520                 525             
Ala Asp His Thr Asn Met Ile His Val Glu Asn Val Tyr Glu Glu Ile
    530                 535                 540                 
Leu His Gln Ile Leu Leu Asp Glu Thr Leu Lys Val Ile Lys Glu Ala
545                 550                 555                 560 
Ala Ile Leu Lys Lys His Asn Leu Phe Glu Asp Asn Met Ala Leu Pro
                565                 570                 575     
Ser Glu Ser Val Ser Ser Leu Thr Asp Leu Lys Pro Pro Thr Gly Ser
            580                 585                 590         
Asn Gln Ala Ser Pro Ala Arg Arg Ala Ser Ala Ile Leu Pro Gly Val
        595                 600                 605             
Leu Gly Ser Glu Thr Leu Ser Asn Glu Val Phe Gln Glu Ser Glu Glu
    610                 615                 620                 
Glu Lys Gln Pro Glu Val Pro Ser Ser Leu Ala Lys Gly Glu Ser Leu
625                 630                 635                 640 
Ser Leu Pro Gly Pro Ser Pro Pro Pro Asp Gly Thr Glu Gln Val Ile
                645                 650                 655     
Ile Ser Arg Val Asp Asp Pro Val Val Asn Pro Val Ala Thr Glu Asp
            660                 665                 670         
Thr Ala Gly Leu Pro Gly Thr Cys Ser Ser Glu Leu Glu Phe Gly Gly
        675                 680                 685             
Thr Leu Glu Asp Glu Glu Pro Ala Gln Glu Glu Pro Glu Pro Ile Thr
    690                 695                 700                 
Ala Ser Gly Ser Leu Lys Ala Leu Arg Lys Leu Leu Thr Ala Ser Val
705                 710                 715                 720 
Glu Val Pro Val Asp Ser Ala Pro Val Met Glu Glu Asp Thr Asn Gly
                725                 730                 735     
Glu Ser His Val Pro Gln Glu Asn Glu Glu Glu Glu Glu Lys Glu Pro
            740                 745                 750         
Ser Gln Ala Ala Ala Ile His Pro Asp Asn Cys Glu Glu Ser Glu Val
        755                 760                 765             
Ser Glu Arg Glu Ala Gln Pro Pro Cys Pro Glu Ala His Gly Glu Glu
    770                 775                 780                 
Leu Gly Gly Phe Pro Glu Val Gly Ser Pro Ala Ser Pro Pro Ala Ser
785                 790                 795                 800 
Gly Gly Leu Thr Glu Glu Pro Leu Gly Pro Met Glu Gly Glu Leu Pro
                805                 810                 815     
Gly Glu Ala Cys Thr Leu Thr Ala His Glu Gly Arg Gly Gly Lys Cys
            820                 825                 830         
Thr Glu Glu Gly Asp Ala Ser Gln Gln Glu Gly Cys Thr Leu Gly Ser
        835                 840                 845             
Asp Pro Ile Cys Leu Ser Glu Ser Gln Val Ser Glu Glu Gln Glu Glu
    850                 855                 860                 
Met Gly Gly Gln Ser Ser Ala Ala Gln Ala Thr Ala Ser Val Asn Ala
865                 870                 875                 880 
Glu Glu Ile Lys Val Ala Arg Ile His Glu Cys Gln Trp Val Val Glu
                885                 890                 895     
Asp Ala Pro Asn Pro Asp Val Leu Leu Ser His Lys Asp Asp Val Lys
            900                 905                 910         
Glu Gly Glu Gly Gly Gln Glu Ser Phe Pro Glu Leu Pro Ser Glu Glu
        915                 920                 925             


<210> 140
<211> 550
<212> PRT
<213> Homo sapiens

<400> 140
Met Trp Lys Ala Ser Ala Gly His Ala Val Ser Ile Ala Gln Asp Asp
 1               5                  10                  15      
Ala Gly Ala Asp Asp Trp Glu Thr Asp Pro Asp Phe Val Asn Asp Val
            20                  25                  30          
Ser Glu Lys Glu Gln Arg Trp Gly Ala Lys Thr Val Gln Gly Ser Gly
        35                  40                  45              
His Gln Glu His Ile Asn Ile His Lys Leu Arg Glu Asn Val Phe Gln
    50                  55                  60                  
Glu His Gln Thr Leu Lys Glu Lys Glu Leu Glu Thr Gly Pro Lys Ala
65                  70                  75                  80  
Ser His Gly Tyr Gly Gly Lys Phe Gly Val Glu Gln Asp Arg Met Asp
                85                  90                  95      
Lys Ser Ala Val Gly His Glu Tyr Gln Ser Lys Leu Ser Lys His Cys
            100                 105                 110         
Ser Gln Val Asp Ser Val Arg Gly Phe Gly Gly Lys Phe Gly Val Gln
        115                 120                 125             
Met Asp Arg Val Asp Gln Ser Ala Val Gly Phe Glu Tyr Gln Gly Lys
    130                 135                 140                 
Thr Glu Lys His Ala Ser Gln Lys Asp Tyr Ser Ser Gly Phe Gly Gly
145                 150                 155                 160 
Lys Tyr Gly Val Gln Ala Asp Arg Val Asp Lys Ser Ala Val Gly Phe
                165                 170                 175     
Asp Tyr Gln Gly Lys Thr Glu Lys His Glu Ser Gln Arg Asp Tyr Ser
            180                 185                 190         
Lys Gly Phe Gly Gly Lys Tyr Gly Ile Asp Lys Asp Lys Val Asp Lys
        195                 200                 205             
Ser Ala Val Gly Phe Glu Tyr Gln Gly Lys Thr Glu Lys His Glu Ser
    210                 215                 220                 
Gln Lys Asp Tyr Val Lys Gly Phe Gly Gly Lys Phe Gly Val Gln Thr
225                 230                 235                 240 
Asp Arg Gln Asp Lys Cys Ala Leu Gly Trp Asp His Gln Glu Lys Leu
                245                 250                 255     
Gln Leu His Glu Ser Gln Lys Asp Tyr Lys Thr Gly Phe Gly Gly Lys
            260                 265                 270         
Phe Gly Val Gln Ser Glu Arg Gln Asp Ser Ala Ala Val Gly Phe Asp
        275                 280                 285             
Tyr Lys Glu Lys Leu Ala Lys His Glu Ser Gln Gln Asp Tyr Ser Lys
    290                 295                 300                 
Gly Phe Gly Gly Lys Tyr Gly Val Gln Lys Asp Arg Met Asp Lys Asn
305                 310                 315                 320 
Ala Ser Thr Phe Glu Asp Val Thr Gln Val Ser Ser Ala Tyr Gln Lys
                325                 330                 335     
Thr Val Pro Val Glu Ala Val Thr Ser Lys Thr Ser Asn Ile Arg Ala
            340                 345                 350         
Asn Phe Glu Asn Leu Ala Lys Glu Lys Glu Gln Glu Asp Arg Arg Lys
        355                 360                 365             
Ala Glu Ala Glu Arg Ala Gln Arg Met Ala Lys Glu Arg Gln Glu Gln
    370                 375                 380                 
Glu Glu Ala Arg Arg Lys Leu Glu Glu Gln Ala Arg Ala Lys Thr Gln
385                 390                 395                 400 
Thr Pro Pro Val Ser Pro Ala Pro Gln Pro Thr Glu Glu Arg Leu Pro
                405                 410                 415     
Ser Ser Pro Val Tyr Glu Asp Ala Ala Ser Phe Lys Ala Glu Leu Ser
            420                 425                 430         
Tyr Arg Gly Pro Val Ser Gly Thr Glu Pro Glu Pro Val Tyr Ser Met
        435                 440                 445             
Glu Ala Ala Asp Tyr Arg Glu Ala Ser Ser Gln Gln Gly Leu Ala Tyr
    450                 455                 460                 
Ala Thr Glu Ala Val Tyr Glu Ser Ala Glu Ala Pro Gly His Tyr Pro
465                 470                 475                 480 
Ala Glu Asp Ser Thr Tyr Asp Glu Tyr Glu Asn Asp Leu Gly Ile Thr
                485                 490                 495     
Ala Val Ala Leu Tyr Asp Tyr Gln Ala Ala Gly Asp Asp Glu Ile Ser
            500                 505                 510         
Phe Asp Pro Asp Asp Ile Ile Thr Asn Ile Glu Met Ile Asp Asp Gly
        515                 520                 525             
Trp Trp Arg Gly Val Cys Lys Gly Arg Tyr Gly Leu Phe Pro Ala Asn
    530                 535                 540                 
Tyr Val Glu Leu Arg Gln
545                 550 


<210> 141
<211> 1255
<212> PRT
<213> Homo sapiens

<400> 141
Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu
 1               5                  10                  15      
Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys
            20                  25                  30          
Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His
        35                  40                  45              
Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr
    50                  55                  60                  
Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val
65                  70                  75                  80  
Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu
                85                  90                  95      
Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr
            100                 105                 110         
Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro
        115                 120                 125             
Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser
    130                 135                 140                 
Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln
145                 150                 155                 160 
Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn
                165                 170                 175     
Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys
            180                 185                 190         
His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser
        195                 200                 205             
Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys
    210                 215                 220                 
Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys
225                 230                 235                 240 
Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu
                245                 250                 255     
His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val
            260                 265                 270         
Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg
        275                 280                 285             
Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu
    290                 295                 300                 
Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln
305                 310                 315                 320 
Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys
                325                 330                 335     
Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu
            340                 345                 350         
Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys
        355                 360                 365             
Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp
    370                 375                 380                 
Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe
385                 390                 395                 400 
Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro
                405                 410                 415     
Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg
            420                 425                 430         
Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu
        435                 440                 445             
Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly
    450                 455                 460                 
Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val
465                 470                 475                 480 
Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr
                485                 490                 495     
Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His
            500                 505                 510         
Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys
        515                 520                 525             
Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys
    530                 535                 540                 
Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys
545                 550                 555                 560 
Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys
                565                 570                 575     
Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp
            580                 585                 590         
Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu
        595                 600                 605             
Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln
    610                 615                 620                 
Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys
625                 630                 635                 640 
Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser
                645                 650                 655     
Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly
            660                 665                 670         
Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg
        675                 680                 685             
Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly
    690                 695                 700                 
Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu
705                 710                 715                 720 
Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys
                725                 730                 735     
Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile
            740                 745                 750         
Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu
        755                 760                 765             
Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg
    770                 775                 780                 
Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu
785                 790                 795                 800 
Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg
                805                 810                 815     
Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly
            820                 825                 830         
Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala
        835                 840                 845             
Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe
    850                 855                 860                 
Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp
865                 870                 875                 880 
Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg
                885                 890                 895     
Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val
            900                 905                 910         
Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala
        915                 920                 925             
Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro
    930                 935                 940                 
Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met
945                 950                 955                 960 
Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe
                965                 970                 975     
Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu
            980                 985                 990         
Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg Ser Leu
        995                 1000                1005            
Leu Glu Asp Asp Asp Met Gly Asp Leu Val Asp Ala Glu Glu Tyr Leu
    1010                1015                1020                
Val Pro Gln Gln Gly Phe Phe Cys Pro Asp Pro Ala Pro Gly Ala Gly
1025                1030                1035                1040
Gly Met Val His His Arg His Arg Ser Ser Ser Thr Arg Ser Gly Gly
                1045                1050                1055    
Gly Asp Leu Thr Leu Gly Leu Glu Pro Ser Glu Glu Glu Ala Pro Arg
            1060                1065                1070        
Ser Pro Leu Ala Pro Ser Glu Gly Ala Gly Ser Asp Val Phe Asp Gly
        1075                1080                1085            
Asp Leu Gly Met Gly Ala Ala Lys Gly Leu Gln Ser Leu Pro Thr His
    1090                1095                1100                
Asp Pro Ser Pro Leu Gln Arg Tyr Ser Glu Asp Pro Thr Val Pro Leu
1105                1110                1115                1120
Pro Ser Glu Thr Asp Gly Tyr Val Ala Pro Leu Thr Cys Ser Pro Gln
                1125                1130                1135    
Pro Glu Tyr Val Asn Gln Pro Asp Val Arg Pro Gln Pro Pro Ser Pro
            1140                1145                1150        
Arg Glu Gly Pro Leu Pro Ala Ala Arg Pro Ala Gly Ala Thr Leu Glu
        1155                1160                1165            
Arg Pro Lys Thr Leu Ser Pro Gly Lys Asn Gly Val Val Lys Asp Val
    1170                1175                1180                
Phe Ala Phe Gly Gly Ala Val Glu Asn Pro Glu Tyr Leu Thr Pro Gln
1185                1190                1195                1200
Gly Gly Ala Ala Pro Gln Pro His Pro Pro Pro Ala Phe Ser Pro Ala
                1205                1210                1215    
Phe Asp Asn Leu Tyr Tyr Trp Asp Gln Asp Pro Pro Glu Arg Gly Ala
            1220                1225                1230        
Pro Pro Ser Thr Phe Lys Gly Thr Pro Thr Ala Glu Asn Pro Glu Tyr
        1235                1240                1245            
Leu Gly Leu Asp Val Pro Val
    1250                1255


<210> 142
<211> 284
<212> PRT
<213> Homo sapiens

<400> 142
Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu
 1               5                  10                  15      
Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Ala Ala
            20                  25                  30          
Glu Asp Arg Ser Lys Gln Leu Glu Asp Glu Leu Val Ser Leu Gln Lys
        35                  40                  45              
Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala Leu
    50                  55                  60                  
Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Thr Asp
65                  70                  75                  80  
Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu
                85                  90                  95      
Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys
            100                 105                 110         
Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys
        115                 120                 125             
Val Ile Glu Ser Arg Ala Gln Lys Asp Glu Glu Lys Met Glu Ile Gln
    130                 135                 140                 
Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ala Asp Arg
145                 150                 155                 160 
Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Ser Asp Leu
                165                 170                 175     
Glu Arg Ala Glu Glu Arg Ala Glu Leu Ser Glu Gly Lys Cys Ala Glu
            180                 185                 190         
Leu Glu Glu Glu Leu Lys Thr Val Thr Asn Asn Leu Lys Ser Leu Glu
        195                 200                 205             
Ala Gln Ala Glu Lys Tyr Ser Gln Lys Glu Asp Arg Tyr Glu Glu Glu
    210                 215                 220                 
Ile Lys Val Leu Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu
225                 230                 235                 240 
Phe Ala Glu Arg Ser Val Thr Lys Leu Glu Lys Ser Ile Asp Asp Leu
                245                 250                 255     
Glu Asp Glu Leu Tyr Ala Gln Lys Leu Lys Tyr Lys Ala Ile Ser Glu
            260                 265                 270         
Glu Leu Asp His Ala Leu Asn Asp Met Thr Ser Ile
        275                 280                 


<210> 143
<211> 471
<212> PRT
<213> Homo sapiens

<400> 143
Met Leu Leu Asn Asp Pro Asp Thr Glu Leu Val Arg Leu Leu Ala Ser
 1               5                  10                  15      
Val Cys Met Gln Val Asn Lys Asp Lys Gly Arg Pro Ser His Gln Pro
            20                  25                  30          
Pro Leu Pro His Ser Lys Val Arg Gln Pro Trp Ser Ile Pro Val Leu
        35                  40                  45              
Pro Asp Asp Lys Gly Gly Leu Lys Ser Trp Trp Asn Arg Met Ser Asn
    50                  55                  60                  
Arg Phe Arg Lys Leu Lys Leu Met Gln Thr Leu Pro Arg Gly Leu Ser
65                  70                  75                  80  
Ser Asn Gln Pro Leu Pro Phe Ser Asp Glu Pro Glu Pro Ala Leu Asp
                85                  90                  95      
Ser Thr Met Arg Ala Ala Pro Gln Asp Lys Thr Ser Arg Ser Ala Leu
            100                 105                 110         
Pro Asp Ala Ala Pro Val Thr Lys Asp Asn Gly Pro Gly Ser Thr Arg
        115                 120                 125             
Gly Glu Lys Glu Asp Thr Leu Leu Thr Thr Met Leu Arg Asn Gly Ala
    130                 135                 140                 
Pro Leu Thr Arg Leu Pro Ser Asp Lys Leu Lys Ala Val Ile Pro Pro
145                 150                 155                 160 
Phe Leu Pro Pro Ser Ser Phe Glu Leu Trp Ser Ser Asp Arg Ser Arg
                165                 170                 175     
Thr Arg His Asn Gly Lys Ala Asp Pro Met Lys Thr Ala Leu Pro Gln
            180                 185                 190         
Arg Ala Ser Arg Gly His Pro Val Gly Gly Gly Gly Thr Asp Thr Thr
        195                 200                 205             
Pro Val Arg Pro Val Lys Phe Pro Ser Leu Pro Arg Ser Pro Ala Ser
    210                 215                 220                 
Ser Ala Asn Ser Gly Asn Phe Asn His Ser Pro His Ser Ser Gly Gly
225                 230                 235                 240 
Ser Ser Gly Ile Gly Val Ser Arg His Gly Gly Glu Leu Leu Asn Arg
                245                 250                 255     
Ser Gly Gly Ser Ile Asp Asn Val Leu Ser Gln Ile Ala Ala Gln Arg
            260                 265                 270         
Lys Lys Ala Ala Gly Leu Leu Glu Gln Lys Pro Ser His Arg Ser Ser
        275                 280                 285             
Pro Val Gly Pro Ala Pro Gly Ser Ser Pro Ser Glu Leu Pro Ala Ser
    290                 295                 300                 
Pro Ala Gly Gly Ser Ala Pro Val Gly Lys Lys Leu Glu Thr Ser Lys
305                 310                 315                 320 
Arg Pro Pro Ser Gly Thr Ser Thr Thr Ser Lys Ser Thr Ser Pro Thr
                325                 330                 335     
Leu Thr Pro Ser Pro Ser Pro Lys Gly His Thr Ala Glu Ser Ser Val
            340                 345                 350         
Ser Ser Ser Ser Ser His Arg Gln Ser Lys Ser Ser Gly Gly Ser Ser
        355                 360                 365             
Ser Gly Thr Ile Thr Asp Glu Asp Glu Leu Thr Gly Ile Leu Lys Lys
    370                 375                 380                 
Leu Ser Leu Glu Lys Tyr Gln Pro Ile Phe Glu Glu Gln Glu Val Asp
385                 390                 395                 400 
Met Glu Ala Phe Leu Thr Leu Thr Asp Gly Asp Leu Lys Glu Leu Gly
                405                 410                 415     
Ile Lys Thr Asp Gly Ser Arg Gln Gln Ile Leu Ala Ala Ile Ser Glu
            420                 425                 430         
Leu Asn Ala Gly Lys Gly Arg Glu Arg Gln Ile Leu Gln Glu Thr Ile
        435                 440                 445             
His Asn Phe His Ser Ser Phe Glu Ser Ser Ala Ser Asn Thr Arg Ala
    450                 455                 460                 
Pro Gly Asn Ser Pro Cys Ala
465                 470     


<210> 144
<211> 1073
<212> PRT
<213> Homo sapiens

<400> 144
Met Ala Ala Ala Gly Gln Leu Cys Leu Leu Tyr Leu Ser Ala Gly Leu
 1               5                  10                  15      
Leu Ser Arg Leu Gly Ala Ala Phe Asn Leu Asp Thr Arg Glu Asp Asn
            20                  25                  30          
Val Ile Arg Lys Tyr Gly Asp Pro Gly Ser Leu Phe Gly Phe Ser Leu
        35                  40                  45              
Ala Met His Trp Gln Leu Gln Pro Glu Asp Lys Arg Leu Leu Leu Val
    50                  55                  60                  
Gly Ala Pro Arg Ala Glu Ala Leu Pro Leu Gln Arg Ala Asn Arg Thr
65                  70                  75                  80  
Gly Gly Leu Tyr Ser Cys Asp Ile Thr Ala Arg Gly Pro Cys Thr Arg
                85                  90                  95      
Ile Glu Phe Asp Asn Asp Ala Asp Pro Thr Ser Glu Ser Lys Glu Asp
            100                 105                 110         
Gln Trp Met Gly Val Thr Val Gln Ser Gln Gly Pro Gly Gly Lys Val
        115                 120                 125             
Val Thr Cys Ala His Arg Tyr Glu Lys Arg Gln His Val Asn Thr Lys
    130                 135                 140                 
Gln Glu Ser Arg Asp Ile Phe Gly Arg Cys Tyr Val Leu Ser Gln Asn
145                 150                 155                 160 
Leu Arg Ile Glu Asp Asp Met Asp Gly Gly Asp Trp Ser Phe Cys Asp
                165                 170                 175     
Gly Arg Leu Arg Gly His Glu Lys Phe Gly Ser Cys Gln Gln Gly Val
            180                 185                 190         
Ala Ala Thr Phe Thr Lys Asp Phe His Tyr Ile Val Phe Gly Ala Pro
        195                 200                 205             
Gly Thr Tyr Asn Trp Lys Gly Ile Val Arg Val Glu Gln Lys Asn Asn
    210                 215                 220                 
Thr Phe Phe Asp Met Asn Ile Phe Glu Asp Gly Pro Tyr Glu Val Gly
225                 230                 235                 240 
Gly Glu Thr Glu His Asp Glu Ser Leu Val Pro Val Pro Ala Asn Ser
                245                 250                 255     
Tyr Leu Gly Phe Ser Leu Asp Ser Gly Lys Gly Ile Val Ser Lys Asp
            260                 265                 270         
Glu Ile Thr Phe Val Ser Gly Ala Pro Arg Ala Asn His Ser Gly Ala
        275                 280                 285             
Val Val Leu Leu Lys Arg Asp Met Lys Ser Ala His Leu Leu Pro Glu
    290                 295                 300                 
His Ile Phe Asp Gly Glu Gly Leu Ala Ser Ser Phe Gly Tyr Asp Val
305                 310                 315                 320 
Ala Val Val Asp Leu Asn Lys Asp Gly Trp Gln Asp Ile Val Ile Gly
                325                 330                 335     
Ala Pro Gln Tyr Phe Asp Arg Asp Gly Glu Val Gly Gly Ala Val Tyr
            340                 345                 350         
Val Tyr Met Asn Gln Gln Gly Arg Trp Asn Asn Val Lys Pro Ile Arg
        355                 360                 365             
Leu Asn Gly Thr Lys Asp Ser Met Phe Gly Ile Ala Val Lys Asn Ile
    370                 375                 380                 
Gly Asp Ile Asn Gln Asp Gly Tyr Pro Asp Ile Ala Val Gly Ala Pro
385                 390                 395                 400 
Tyr Asp Asp Leu Gly Lys Val Phe Ile Tyr His Gly Ser Ala Asn Gly
                405                 410                 415     
Ile Asn Thr Lys Pro Thr Gln Val Leu Lys Gly Ile Ser Pro Tyr Phe
            420                 425                 430         
Gly Tyr Ser Ile Ala Gly Asn Met Asp Leu Asp Arg Asn Ser Tyr Pro
        435                 440                 445             
Asp Val Ala Val Gly Ser Leu Ser Asp Ser Val Thr Ile Phe Arg Ser
    450                 455                 460                 
Arg Pro Val Ile Asn Ile Gln Lys Thr Ile Thr Val Thr Pro Asn Arg
465                 470                 475                 480 
Ile Asp Leu Arg Gln Lys Thr Ala Cys Gly Ala Pro Ser Gly Ile Cys
                485                 490                 495     
Leu Gln Val Lys Ser Cys Phe Glu Tyr Thr Ala Asn Pro Ala Gly Tyr
            500                 505                 510         
Asn Pro Ser Ile Ser Ile Val Gly Thr Leu Glu Ala Glu Lys Glu Arg
        515                 520                 525             
Arg Lys Ser Gly Leu Ser Ser Arg Val Gln Phe Arg Asn Gln Gly Ser
    530                 535                 540                 
Glu Pro Lys Tyr Thr Gln Glu Leu Thr Leu Lys Arg Gln Lys Gln Lys
545                 550                 555                 560 
Val Cys Met Glu Glu Thr Leu Trp Leu Gln Asp Asn Ile Arg Asp Lys
                565                 570                 575     
Leu Arg Pro Ile Pro Ile Thr Ala Ser Val Glu Ile Gln Glu Pro Ser
            580                 585                 590         
Ser Arg Arg Arg Val Asn Ser Leu Pro Glu Val Leu Pro Ile Leu Asn
        595                 600                 605             
Ser Asp Glu Pro Lys Thr Ala His Ile Asp Val His Phe Leu Lys Glu
    610                 615                 620                 
Gly Cys Gly Asp Asp Asn Val Cys Asn Ser Asn Leu Lys Leu Glu Tyr
625                 630                 635                 640 
Lys Phe Cys Thr Arg Glu Gly Asn Gln Asp Lys Phe Ser Tyr Leu Pro
                645                 650                 655     
Ile Gln Lys Gly Val Pro Glu Leu Val Leu Lys Asp Gln Lys Asp Ile
            660                 665                 670         
Ala Leu Glu Ile Thr Val Thr Asn Ser Pro Ser Asn Pro Arg Asn Pro
        675                 680                 685             
Thr Lys Asp Gly Asp Asp Ala His Glu Ala Lys Leu Ile Ala Thr Phe
    690                 695                 700                 
Pro Asp Thr Leu Thr Tyr Ser Ala Tyr Arg Glu Leu Arg Ala Phe Pro
705                 710                 715                 720 
Glu Lys Gln Leu Ser Cys Val Ala Asn Gln Asn Gly Ser Gln Ala Asp
                725                 730                 735     
Cys Glu Leu Gly Asn Pro Phe Lys Arg Asn Ser Asn Val Thr Phe Tyr
            740                 745                 750         
Leu Val Leu Ser Thr Thr Glu Val Thr Phe Asp Thr Pro Asp Leu Asp
        755                 760                 765             
Ile Asn Leu Lys Leu Glu Thr Thr Ser Asn Gln Asp Asn Leu Ala Pro
    770                 775                 780                 
Ile Thr Ala Lys Ala Lys Val Val Ile Glu Leu Leu Leu Ser Val Ser
785                 790                 795                 800 
Gly Val Ala Lys Pro Ser Gln Val Tyr Phe Gly Gly Thr Val Val Gly
                805                 810                 815     
Glu Gln Ala Met Lys Ser Glu Asp Glu Val Gly Ser Leu Ile Glu Tyr
            820                 825                 830         
Glu Phe Arg Val Ile Asn Leu Gly Lys Pro Leu Thr Asn Leu Gly Thr
        835                 840                 845             
Ala Thr Leu Asn Ile Gln Trp Pro Lys Glu Ile Ser Asn Gly Lys Trp
    850                 855                 860                 
Leu Leu Tyr Leu Val Lys Val Glu Ser Lys Gly Leu Glu Lys Val Thr
865                 870                 875                 880 
Cys Glu Pro Gln Lys Glu Ile Asn Ser Leu Asn Leu Thr Glu Ser His
                885                 890                 895     
Asn Ser Arg Lys Lys Arg Glu Ile Thr Glu Lys Gln Ile Asp Asp Asn
            900                 905                 910         
Arg Lys Phe Ser Leu Phe Ala Glu Arg Lys Tyr Gln Thr Leu Asn Cys
        915                 920                 925             
Ser Val Asn Val Asn Cys Val Asn Ile Arg Cys Pro Leu Arg Gly Leu
    930                 935                 940                 
Asp Ser Lys Ala Ser Leu Ile Leu Arg Ser Arg Leu Trp Asn Ser Thr
945                 950                 955                 960 
Phe Leu Glu Glu Tyr Ser Lys Leu Asn Tyr Leu Asp Ile Leu Met Arg
                965                 970                 975     
Ala Phe Ile Asp Val Thr Ala Ala Ala Glu Asn Ile Arg Leu Pro Asn
            980                 985                 990         
Ala Gly Thr Gln Val Arg Val Thr Val Phe Pro Ser Lys Thr Val Ala
        995                 1000                1005            
Gln Tyr Ser Gly Val Pro Trp Trp Ile Ile Leu Val Ala Ile Leu Ala
    1010                1015                1020                
Gly Ile Leu Met Leu Ala Leu Leu Val Phe Ile Leu Trp Lys Cys Gly
1025                1030                1035                1040
Phe Phe Lys Arg Asn Lys Lys Asp His Tyr Asp Ala Thr Tyr His Lys
                1045                1050                1055    
Ala Glu Ile His Ala Gln Pro Ser Asp Lys Glu Arg Leu Thr Ser Asp
            1060                1065                1070        
Ala
    


<210> 145
<211> 227
<212> PRT
<213> Homo sapiens

<400> 145
Met Glu Lys Leu Phe Asn Glu Asn Glu Gly Met Pro Ser Asn Gln Gly
 1               5                  10                  15      
Lys Ile Asp Asn Glu Glu Gln Pro Pro His Glu Gly Lys Pro Glu Val
            20                  25                  30          
Ala Cys Ile Leu Glu Asp Lys Lys Leu Glu Asn Glu Gly Asn Thr Glu
        35                  40                  45              
Asn Thr Gly Lys Arg Val Glu Glu Pro Leu Lys Asp Lys Glu Lys Pro
    50                  55                  60                  
Glu Ser Ala Gly Lys Ala Lys Gly Glu Gly Lys Ser Glu Arg Lys Gly
65                  70                  75                  80  
Lys Ser Glu Met Gln Gly Gly Ser Lys Thr Glu Gly Lys Pro Glu Arg
                85                  90                  95      
Gly Gly Arg Ala Glu Gly Glu Gly Glu Pro Asp Ser Glu Arg Glu Pro
            100                 105                 110         
Glu Ser Glu Gly Glu Pro Glu Ser Glu Thr Arg Ala Ala Gly Lys Arg
        115                 120                 125             
Pro Ala Glu Asp Asp Ile Pro Arg Lys Ala Lys Arg Lys Thr Asn Lys
    130                 135                 140                 
Gly Leu Ala Gln Tyr Leu Lys Gln Tyr Lys Glu Ala Ile His Asp Met
145                 150                 155                 160 
Asn Phe Ser Asn Glu Asp Met Ile Arg Glu Phe Asp Asn Met Ala Arg
                165                 170                 175     
Val Glu Asp Lys Arg Arg Lys Ser Lys Gln Lys Leu Gly Ala Phe Leu
            180                 185                 190         
Trp Met Gln Arg Asn Leu Gln Asp Pro Phe Tyr Pro Arg Gly Pro Arg
        195                 200                 205             
Glu Phe Arg Gly Gly Cys Arg Ala Pro Arg Arg Asp Thr Glu Asp Ile
    210                 215                 220                 
Pro Tyr Val
225         


<210> 146
<211> 117
<212> PRT
<213> Homo sapiens

<400> 146
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp
 1               5                  10                  15      
Leu Pro Gly Ala Lys Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Thr
            20                  25                  30          
Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
        35                  40                  45              
Gln Ser Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys
    50                  55                  60                  
Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val
65                  70                  75                  80  
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr
                85                  90                  95      
Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
            100                 105                 110         
Tyr Asn Ser Tyr Ser
        115         


<210> 147
<211> 284
<212> PRT
<213> Homo sapiens

<400> 147
Met Asp Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys Glu
 1               5                  10                  15      
Asn Ala Ile Asp Arg Ala Glu Gln Ala Glu Ala Asp Lys Lys Gln Ala
            20                  25                  30          
Glu Asp Arg Cys Lys Gln Leu Glu Glu Glu Gln Gln Ala Leu Gln Lys
        35                  40                  45              
Lys Leu Lys Gly Thr Glu Asp Glu Val Glu Lys Tyr Ser Glu Ser Val
    50                  55                  60                  
Lys Glu Ala Gln Glu Lys Leu Glu Gln Ala Glu Lys Lys Ala Thr Asp
65                  70                  75                  80  
Ala Glu Ala Asp Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu
                85                  90                  95      
Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys
            100                 105                 110         
Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys
        115                 120                 125             
Val Ile Glu Asn Arg Ala Met Lys Asp Glu Glu Lys Met Glu Leu Gln
    130                 135                 140                 
Glu Met Gln Leu Lys Glu Ala Lys His Ile Ala Glu Asp Ser Asp Arg
145                 150                 155                 160 
Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Leu Glu Gly Glu Leu
                165                 170                 175     
Glu Arg Ser Glu Glu Arg Ala Glu Val Ala Glu Ser Arg Ala Arg Gln
            180                 185                 190         
Leu Glu Glu Glu Leu Arg Thr Met Asp Gln Ala Leu Lys Ser Leu Met
        195                 200                 205             
Ala Ser Glu Glu Glu Tyr Ser Thr Lys Glu Asp Lys Tyr Glu Glu Glu
    210                 215                 220                 
Ile Lys Leu Leu Glu Glu Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu
225                 230                 235                 240 
Phe Ala Glu Arg Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu
                245                 250                 255     
Glu Glu Thr Leu Ala Ser Ala Lys Glu Glu Asn Val Glu Ile His Gln
            260                 265                 270         
Thr Leu Asp Gln Thr Leu Leu Glu Leu Asn Asn Leu
        275                 280                 


<210> 148
<211> 460
<212> PRT
<213> Homo sapiens

<400> 148
Met Asn Lys Pro Ile Thr Pro Ser Thr Tyr Val Arg Cys Leu Asn Val
 1               5                  10                  15      
Gly Leu Ile Arg Lys Leu Ser Asp Phe Ile Asp Pro Gln Glu Gly Trp
            20                  25                  30          
Lys Lys Leu Ala Val Ala Ile Lys Lys Pro Ser Gly Asp Asp Arg Tyr
        35                  40                  45              
Asn Gln Phe His Ile Arg Arg Phe Glu Ala Leu Leu Gln Thr Gly Lys
    50                  55                  60                  
Ser Pro Thr Ser Glu Leu Leu Phe Asp Trp Gly Thr Thr Asn Cys Thr
65                  70                  75                  80  
Val Gly Asp Leu Val Asp Leu Leu Ile Gln Asn Glu Phe Phe Ala Pro
                85                  90                  95      
Ala Ser Leu Leu Leu Pro Asp Ala Val Pro Lys Thr Ala Asn Thr Leu
            100                 105                 110         
Pro Ser Lys Glu Ala Ile Thr Val Gln Gln Lys Gln Met Pro Phe Cys
        115                 120                 125             
Asp Lys Asp Arg Thr Leu Met Thr Pro Val Gln Asn Leu Glu Gln Ser
    130                 135                 140                 
Tyr Met Pro Pro Asp Ser Ser Ser Pro Glu Asn Lys Ser Leu Glu Val
145                 150                 155                 160 
Ser Asp Thr Arg Phe His Ser Phe Ser Phe Tyr Glu Leu Lys Asn Val
                165                 170                 175     
Thr Asn Asn Phe Asp Glu Arg Pro Ile Ser Val Gly Gly Asn Lys Met
            180                 185                 190         
Gly Glu Gly Gly Phe Gly Val Val Tyr Lys Gly Tyr Val Asn Asn Thr
        195                 200                 205             
Thr Val Ala Val Lys Lys Leu Ala Ala Met Val Asp Ile Thr Thr Glu
    210                 215                 220                 
Glu Leu Lys Gln Gln Phe Asp Gln Glu Ile Lys Val Met Ala Lys Cys
225                 230                 235                 240 
Gln His Glu Asn Leu Val Glu Leu Leu Gly Phe Ser Ser Asp Gly Asp
                245                 250                 255     
Asp Leu Cys Leu Val Tyr Val Tyr Met Pro Asn Gly Ser Leu Leu Asp
            260                 265                 270         
Arg Leu Ser Cys Leu Asp Gly Thr Pro Pro Leu Ser Trp His Met Arg
        275                 280                 285             
Cys Lys Ile Ala Gln Gly Ala Ala Asn Gly Ile Asn Phe Leu His Glu
    290                 295                 300                 
Asn His His Ile His Arg Asp Ile Lys Ser Ala Asn Ile Leu Leu Asp
305                 310                 315                 320 
Glu Ala Phe Thr Ala Lys Ile Ser Asp Phe Gly Leu Ala Arg Ala Ser
                325                 330                 335     
Glu Lys Phe Ala Gln Thr Val Met Thr Ser Arg Ile Val Gly Thr Thr
            340                 345                 350         
Ala Tyr Met Ala Pro Glu Ala Leu Arg Gly Glu Ile Thr Pro Lys Ser
        355                 360                 365             
Asp Ile Tyr Ser Phe Gly Val Val Leu Leu Glu Ile Ile Thr Gly Leu
    370                 375                 380                 
Pro Ala Val Asp Glu His Arg Glu Pro Gln Leu Leu Leu Asp Ile Lys
385                 390                 395                 400 
Glu Glu Ile Glu Asp Glu Glu Lys Thr Ile Glu Asp Tyr Ile Asp Lys
                405                 410                 415     
Lys Met Asn Asp Ala Asp Ser Thr Ser Val Glu Ala Met Tyr Ser Val
            420                 425                 430         
Ala Ser Gln Cys Leu His Glu Lys Lys Asn Lys Arg Pro Asp Ile Lys
        435                 440                 445             
Lys Val Gln Gln Leu Leu Gln Glu Met Thr Ala Ser
    450                 455                 460 


<210> 149
<211> 120
<212> PRT
<213> Homo sapiens

<400> 149
Met Trp Ala Ser Glu Leu Arg Gly Pro Gly Cys Ala Asp Ser Leu Asn
 1               5                  10                  15      
Ala Ala Leu Ala His Ser Pro Leu Arg Asn Arg Gln Cys Arg Gly Phe
            20                  25                  30          
Pro Gly Gly Gly His Ser Ile Gln Pro Leu Tyr Thr Pro Arg Ala Pro
        35                  40                  45              
Ala Ala Ala Pro Pro Pro Pro His Lys Met Ala Ala Pro Ile Glu Glu
    50                  55                  60                  
Thr Ala Ala Ala Ser Pro Ala Pro Phe Cys Gly Arg Arg Glu Ile Cys
65                  70                  75                  80  
Gln His Gly Lys Pro Leu Leu Arg Met His Pro Ser Leu Glu Thr Pro
                85                  90                  95      
Leu Lys Gly Trp Ser Leu Gly Asp His Ile Lys Arg Lys Met Pro Thr
            100                 105                 110         
Thr Ser Thr Thr Ser Thr Arg Phe
        115                 120 


<210> 150
<211> 527
<212> PRT
<213> Homo sapiens

<400> 150
Met Ser Leu Cys Gly Ala Arg Ala Asn Ala Lys Met Met Ala Ala Tyr
 1               5                  10                  15      
Asn Gly Gly Thr Ser Ala Ala Ala Ala Gly His His His His His His
            20                  25                  30          
His His Leu Pro His Leu Pro Pro Pro His Leu His His His His His
        35                  40                  45              
Pro Gln His His Leu His Pro Gly Ser Ala Ala Ala Val His Pro Val
    50                  55                  60                  
Gln Gln His Thr Ser Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala
65                  70                  75                  80  
Ala Ala Ala Met Leu Asn Pro Gly Gln Gln Gln Pro Tyr Phe Pro Ser
                85                  90                  95      
Pro Ala Pro Gly Gln Ala Pro Gly Pro Ala Ala Ala Ala Pro Ala Gln
            100                 105                 110         
Val Gln Ala Ala Ala Ala Ala Thr Val Lys Ala His His His Gln His
        115                 120                 125             
Ser His His Pro Gln Gln Gln Leu Asp Ile Glu Pro Asp Arg Pro Ile
    130                 135                 140                 
Gly Tyr Gly Ala Phe Gly Val Val Trp Ser Val Thr Asp Pro Arg Asp
145                 150                 155                 160 
Gly Lys Arg Val Ala Leu Lys Lys Met Pro Asn Val Phe Gln Asn Leu
                165                 170                 175     
Val Ser Cys Lys Arg Val Phe Arg Glu Leu Lys Met Leu Cys Phe Phe
            180                 185                 190         
Lys His Asp Asn Val Leu Ser Ala Leu Asp Ile Leu Gln Pro Pro His
        195                 200                 205             
Ile Asp Tyr Phe Glu Glu Ile Tyr Val Val Thr Glu Leu Met Gln Ser
    210                 215                 220                 
Asp Leu His Lys Ile Ile Val Ser Pro Gln Pro Leu Ser Ser Asp His
225                 230                 235                 240 
Val Lys Val Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Leu His
                245                 250                 255     
Ser Ala Gly Ile Leu His Arg Asp Ile Lys Pro Gly Asn Leu Leu Val
            260                 265                 270         
Asn Ser Asn Cys Val Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Val
        275                 280                 285             
Glu Glu Leu Asp Glu Ser Arg His Met Thr Gln Glu Val Val Thr Gln
    290                 295                 300                 
Tyr Tyr Arg Ala Pro Glu Ile Leu Met Gly Ser Arg His Tyr Ser Asn
305                 310                 315                 320 
Ala Ile Asp Ile Trp Ser Val Gly Cys Ile Phe Ala Glu Leu Leu Gly
                325                 330                 335     
Arg Arg Ile Leu Phe Gln Ala Gln Ser Pro Ile Gln Gln Leu Asp Leu
            340                 345                 350         
Ile Thr Asp Leu Leu Gly Thr Pro Ser Leu Glu Ala Met Arg Thr Ala
        355                 360                 365             
Cys Glu Gly Ala Lys Ala His Ile Leu Arg Gly Pro His Lys Gln Pro
    370                 375                 380                 
Ser Leu Pro Val Leu Tyr Thr Leu Ser Ser Gln Ala Thr His Glu Ala
385                 390                 395                 400 
Val His Leu Leu Cys Arg Met Leu Val Phe Asp Pro Ser Lys Arg Ile
                405                 410                 415     
Ser Ala Lys Asp Ala Leu Ala His Pro Tyr Leu Asp Glu Gly Arg Leu
            420                 425                 430         
Arg Tyr His Thr Cys Met Cys Lys Cys Cys Phe Ser Thr Ser Thr Gly
        435                 440                 445             
Arg Val Tyr Thr Ser Asp Phe Glu Pro Val Thr Asn Pro Lys Phe Asp
    450                 455                 460                 
Asp Thr Phe Glu Lys Asn Leu Ser Ser Val Arg Gln Val Lys Glu Ile
465                 470                 475                 480 
Ile His Gln Phe Ile Leu Glu Gln Gln Lys Gly Asn Arg Val Pro Leu
                485                 490                 495     
Cys Ile Asn Pro Gln Ser Ala Ala Phe Lys Ser Phe Ile Ser Ser Thr
            500                 505                 510         
Val Ala Gln Pro Ser Glu Met Pro Pro Ser Pro Leu Val Trp Glu
        515                 520                 525         


<210> 151
<211> 248
<212> PRT
<213> Homo sapiens

<400> 151
Met Arg Leu Ile Gln Asn Met Cys Thr Ile Ala Glu Tyr Pro Ala Pro
 1               5                  10                  15      
Gly Asn Ala Ala Ala Ser Asp Cys Cys Val Gly Ala Ala Gly Arg Arg
            20                  25                  30          
Leu Val Lys Ile Ala Val Val Gly Ala Ser Gly Val Gly Lys Thr Ala
        35                  40                  45              
Leu Val Val Arg Phe Leu Thr Lys Arg Phe Ile Gly Asp Tyr Glu Arg
    50                  55                  60                  
Asn Ala Gly Asn Leu Tyr Thr Arg Gln Val Gln Ile Glu Gly Glu Thr
65                  70                  75                  80  
Leu Ala Leu Gln Val Gln Asp Thr Pro Gly Ile Gln Val His Glu Asn
                85                  90                  95      
Ser Leu Ser Cys Ser Glu Gln Leu Asn Arg Cys Ile Arg Trp Ala Asp
            100                 105                 110         
Ala Val Val Ile Val Phe Ser Ile Thr Asp Tyr Lys Ser Tyr Glu Leu
        115                 120                 125             
Ile Ser Gln Leu His Gln His Val Gln Gln Leu His Leu Gly Thr Arg
    130                 135                 140                 
Leu Pro Val Val Val Val Ala Asn Lys Ala Asp Leu Leu His Ile Lys
145                 150                 155                 160 
Gln Val Asp Pro Gln Leu Gly Leu Gln Leu Ala Ser Met Leu Gly Cys
                165                 170                 175     
Ser Phe Tyr Glu Val Ser Val Ser Glu Asn Tyr Asn Asp Val Tyr Ser
            180                 185                 190         
Ala Phe His Val Leu Cys Lys Glu Val Ser His Lys Gln Gln Pro Ser
        195                 200                 205             
Ser Thr Pro Glu Lys Arg Arg Thr Ser Leu Ile Pro Arg Pro Lys Ser
    210                 215                 220                 
Pro Asn Met Gln Asp Leu Lys Arg Arg Phe Lys Gln Ala Leu Ser Ala
225                 230                 235                 240 
Lys Val Arg Thr Val Thr Ser Val
                245             


<210> 152
<211> 592
<212> PRT
<213> Homo sapiens

<400> 152
Met Pro Ser Arg Thr Gly Pro Lys Met Glu Gly Ser Gly Gly Arg Val
 1               5                  10                  15      
Arg Leu Lys Ala His Tyr Gly Gly Asp Ile Phe Ile Thr Ser Val Asp
            20                  25                  30          
Ala Ala Thr Thr Phe Glu Glu Leu Cys Glu Glu Val Arg Asp Met Cys
        35                  40                  45              
Arg Leu His Gln Gln His Pro Leu Thr Leu Lys Trp Val Asp Ser Glu
    50                  55                  60                  
Gly Asp Pro Cys Thr Val Ser Ser Gln Met Glu Leu Glu Glu Ala Phe
65                  70                  75                  80  
Arg Leu Ala Arg Gln Cys Arg Asp Glu Gly Leu Ile Ile His Val Phe
                85                  90                  95      
Pro Ser Thr Pro Glu Gln Pro Gly Leu Pro Cys Pro Gly Glu Asp Lys
            100                 105                 110         
Ser Ile Tyr Arg Arg Gly Ala Arg Arg Trp Arg Lys Leu Tyr Arg Ala
        115                 120                 125             
Asn Gly His Leu Phe Gln Ala Lys Arg Phe Asn Arg Arg Ala Tyr Cys
    130                 135                 140                 
Gly Gln Cys Ser Glu Arg Ile Trp Gly Leu Ala Arg Gln Gly Tyr Arg
145                 150                 155                 160 
Cys Ile Asn Cys Lys Leu Leu Val His Lys Arg Cys His Gly Leu Val
                165                 170                 175     
Pro Leu Thr Cys Arg Lys His Met Asp Ser Val Met Pro Ser Gln Glu
            180                 185                 190         
Pro Pro Val Asp Asp Lys Asn Glu Asp Ala Asp Leu Pro Ser Glu Glu
        195                 200                 205             
Thr Asp Gly Ile Ala Tyr Ile Ser Ser Ser Arg Lys His Asp Ser Ile
    210                 215                 220                 
Lys Asp Asp Ser Glu Asp Leu Lys Pro Val Ile Asp Gly Met Asp Gly
225                 230                 235                 240 
Ile Lys Ile Ser Gln Gly Leu Gly Leu Gln Asp Phe Asp Leu Ile Arg
                245                 250                 255     
Val Ile Gly Arg Gly Ser Tyr Ala Lys Val Leu Leu Val Arg Leu Lys
            260                 265                 270         
Lys Asn Asp Gln Ile Tyr Ala Met Lys Val Val Lys Lys Glu Leu Val
        275                 280                 285             
His Asp Asp Glu Asp Ile Asp Trp Val Gln Thr Glu Lys His Val Phe
    290                 295                 300                 
Glu Gln Ala Ser Ser Asn Pro Phe Leu Val Gly Leu His Ser Cys Phe
305                 310                 315                 320 
Gln Thr Thr Ser Arg Leu Phe Leu Val Ile Glu Tyr Val Asn Gly Gly
                325                 330                 335     
Asp Leu Met Phe His Met Gln Arg Gln Arg Lys Leu Pro Glu Glu His
            340                 345                 350         
Ala Arg Phe Tyr Ala Ala Glu Ile Cys Ile Ala Leu Asn Phe Leu His
        355                 360                 365             
Glu Arg Gly Ile Ile Tyr Arg Asp Leu Lys Leu Asp Asn Val Leu Leu
    370                 375                 380                 
Asp Ala Asp Gly His Ile Lys Leu Thr Asp Tyr Gly Met Cys Lys Glu
385                 390                 395                 400 
Gly Leu Gly Pro Gly Asp Thr Thr Ser Thr Phe Cys Gly Thr Pro Asn
                405                 410                 415     
Tyr Ile Ala Pro Glu Ile Leu Arg Gly Glu Glu Tyr Gly Phe Ser Val
            420                 425                 430         
Asp Trp Trp Ala Leu Gly Val Leu Met Phe Glu Met Met Ala Gly Arg
        435                 440                 445             
Ser Pro Phe Asp Ile Ile Thr Asp Asn Pro Asp Met Asn Thr Glu Asp
    450                 455                 460                 
Tyr Leu Phe Gln Val Ile Leu Glu Lys Pro Ile Arg Ile Pro Arg Phe
465                 470                 475                 480 
Leu Ser Val Lys Ala Ser His Val Leu Lys Gly Phe Leu Asn Lys Asp
                485                 490                 495     
Pro Lys Glu Arg Leu Gly Cys Arg Pro Gln Thr Gly Phe Ser Asp Ile
            500                 505                 510         
Lys Ser His Ala Phe Phe Arg Ser Ile Asp Trp Asp Leu Leu Glu Lys
        515                 520                 525             
Lys Gln Ala Leu Pro Pro Phe Gln Pro Gln Ile Thr Asp Asp Tyr Gly
    530                 535                 540                 
Leu Asp Asn Phe Asp Thr Gln Phe Thr Ser Glu Pro Val Gln Leu Thr
545                 550                 555                 560 
Pro Asp Asp Glu Asp Ala Ile Lys Arg Ile Asp Gln Ser Glu Phe Glu
                565                 570                 575     
Gly Phe Glu Tyr Ile Asn Pro Leu Leu Leu Ser Thr Glu Glu Ser Val
            580                 585                 590         


<210> 153
<211> 673
<212> PRT
<213> Homo sapiens

<400> 153
Met Ala Asp Pro Ala Ala Gly Pro Pro Pro Ser Glu Gly Glu Glu Ser
 1               5                  10                  15      
Thr Val Arg Phe Ala Arg Lys Gly Ala Leu Arg Gln Lys Asn Val His
            20                  25                  30          
Glu Val Lys Asn His Lys Phe Thr Ala Arg Phe Phe Lys Gln Pro Thr
        35                  40                  45              
Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys Gln Gly
    50                  55                  60                  
Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys His Glu
65                  70                  75                  80  
Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Ala Ser Asp
                85                  90                  95      
Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Ser Ser Pro
            100                 105                 110         
Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile His Gln
        115                 120                 125             
Gly Met Lys Cys Asp Thr Cys Met Met Asn Val His Lys Arg Cys Val
    130                 135                 140                 
Met Asn Val Pro Ser Leu Cys Gly Thr Asp His Thr Glu Arg Arg Gly
145                 150                 155                 160 
Arg Ile Tyr Ile Gln Ala His Ile Asp Arg Asp Val Leu Ile Val Leu
                165                 170                 175     
Val Arg Asp Ala Lys Asn Leu Val Pro Met Asp Pro Asn Gly Leu Ser
            180                 185                 190         
Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Ser Glu Ser
        195                 200                 205             
Lys Gln Lys Thr Lys Thr Ile Lys Cys Ser Leu Asn Pro Glu Trp Asn
    210                 215                 220                 
Glu Thr Phe Arg Phe Gln Leu Lys Glu Ser Asp Lys Asp Arg Arg Leu
225                 230                 235                 240 
Ser Val Glu Ile Trp Asp Trp Asp Leu Thr Ser Arg Asn Asp Phe Met
                245                 250                 255     
Gly Ser Leu Ser Phe Gly Ile Ser Glu Leu Gln Lys Ala Ser Val Asp
            260                 265                 270         
Gly Trp Phe Lys Leu Leu Ser Gln Glu Glu Gly Glu Tyr Phe Asn Val
        275                 280                 285             
Pro Val Pro Pro Glu Gly Ser Glu Ala Asn Glu Glu Leu Arg Gln Lys
    290                 295                 300                 
Phe Glu Arg Ala Lys Ile Ser Gln Gly Thr Lys Val Pro Glu Glu Lys
305                 310                 315                 320 
Thr Thr Asn Thr Val Ser Lys Phe Asp Asn Asn Gly Asn Arg Asp Arg
                325                 330                 335     
Met Lys Leu Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys Gly Ser
            340                 345                 350         
Phe Gly Lys Val Met Leu Ser Glu Arg Lys Gly Thr Asp Glu Leu Tyr
        355                 360                 365             
Ala Val Lys Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp Asp Val
    370                 375                 380                 
Glu Cys Thr Met Val Glu Lys Arg Val Leu Ala Leu Pro Gly Lys Pro
385                 390                 395                 400 
Pro Phe Leu Thr Gln Leu His Ser Cys Phe Gln Thr Met Asp Arg Leu
                405                 410                 415     
Tyr Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Tyr His Ile
            420                 425                 430         
Gln Gln Val Gly Arg Phe Lys Glu Pro His Ala Val Phe Tyr Ala Ala
        435                 440                 445             
Glu Ile Ala Ile Gly Leu Phe Phe Leu Gln Ser Lys Gly Ile Ile Tyr
    450                 455                 460                 
Arg Asp Leu Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly His Ile
465                 470                 475                 480 
Lys Ile Ala Asp Phe Gly Met Cys Lys Glu Asn Ile Trp Asp Gly Val
                485                 490                 495     
Thr Thr Lys Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile
            500                 505                 510         
Ile Ala Tyr Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala Phe Gly
        515                 520                 525             
Val Leu Leu Tyr Glu Met Leu Ala Gly Gln Ala Pro Phe Glu Gly Glu
    530                 535                 540                 
Asp Glu Asp Glu Leu Phe Gln Ser Ile Met Glu His Asn Val Ala Tyr
545                 550                 555                 560 
Pro Lys Ser Met Ser Lys Glu Ala Val Ala Ile Cys Lys Gly Leu Met
                565                 570                 575     
Thr Lys His Pro Gly Lys Arg Leu Gly Cys Gly Pro Glu Gly Glu Arg
            580                 585                 590         
Asp Ile Lys Glu His Ala Phe Phe Arg Tyr Ile Asp Trp Glu Lys Leu
        595                 600                 605             
Glu Arg Lys Glu Ile Gln Pro Pro Tyr Lys Pro Lys Ala Cys Gly Arg
    610                 615                 620                 
Asn Ala Glu Asn Phe Asp Arg Phe Phe Thr Arg His Pro Pro Val Leu
625                 630                 635                 640 
Thr Pro Pro Asp Gln Glu Val Ile Arg Asn Ile Asp Gln Ser Glu Phe
                645                 650                 655     
Glu Gly Phe Ser Phe Val Asn Ser Glu Phe Leu Lys Pro Glu Val Lys
            660                 665                 670         
Ser
    


<210> 154
<211> 312
<212> PRT
<213> Homo sapiens

<400> 154
Met Ala Asp Phe Gly Ile Ser Ala Gly Gln Phe Val Ala Val Val Trp
 1               5                  10                  15      
Asp Lys Ser Ser Pro Val Glu Ala Leu Lys Gly Leu Val Asp Lys Leu
            20                  25                  30          
Gln Ala Leu Thr Gly Asn Glu Gly Arg Val Ser Val Glu Asn Ile Lys
        35                  40                  45              
Gln Leu Leu Gln Ser Ala His Lys Glu Ser Ser Phe Asp Ile Ile Leu
    50                  55                  60                  
Ser Gly Leu Val Pro Gly Ser Thr Thr Leu His Ser Ala Glu Ile Leu
65                  70                  75                  80  
Ala Glu Ile Ala Arg Ile Leu Arg Pro Gly Gly Cys Leu Phe Leu Lys
                85                  90                  95      
Glu Pro Val Glu Thr Ala Val Asp Asn Asn Ser Lys Val Lys Thr Ala
            100                 105                 110         
Ser Lys Leu Cys Ser Ala Leu Thr Leu Ser Gly Leu Val Glu Val Lys
        115                 120                 125             
Glu Leu Gln Arg Glu Pro Leu Thr Pro Glu Glu Val Gln Ser Val Arg
    130                 135                 140                 
Glu His Leu Gly His Glu Ser Asp Asn Leu Leu Phe Val Gln Ile Thr
145                 150                 155                 160 
Gly Lys Lys Pro Asn Phe Glu Val Gly Ser Ser Arg Gln Leu Lys Leu
                165                 170                 175     
Ser Ile Thr Lys Lys Ser Ser Pro Ser Val Lys Pro Ala Val Asp Pro
            180                 185                 190         
Ala Ala Ala Lys Leu Trp Thr Leu Ser Ala Asn Asp Met Glu Asp Asp
        195                 200                 205             
Ser Met Asp Leu Ile Asp Ser Asp Glu Leu Leu Asp Pro Glu Asp Leu
    210                 215                 220                 
Lys Lys Pro Asp Pro Ala Ser Leu Arg Ala Ala Ser Cys Gly Glu Gly
225                 230                 235                 240 
Lys Lys Arg Lys Ala Cys Lys Asn Cys Thr Cys Gly Leu Ala Glu Glu
                245                 250                 255     
Leu Glu Lys Glu Lys Ser Arg Glu Gln Met Ser Ser Gln Pro Lys Ser
            260                 265                 270         
Ala Cys Gly Asn Cys Tyr Leu Gly Asp Ala Phe Arg Cys Ala Ser Cys
        275                 280                 285             
Pro Tyr Leu Gly Met Pro Ala Phe Lys Pro Gly Glu Lys Val Leu Leu
    290                 295                 300                 
Ser Asp Ser Asn Leu His Asp Ala
305                 310         


<210> 155
<211> 546
<212> PRT
<213> Homo sapiens

<400> 155
Asp Arg Gly Ser Gly Ala Phe Ser Leu Glu Thr Ile Ala Glu Ser Ser
 1               5                  10                  15      
Ala Gln Ser Pro Gly Cys Gln Leu Leu Val Glu Thr Leu Gly Val Pro
            20                  25                  30          
Leu Gln Glu Ala Thr Glu Leu Gly Asp Pro Thr Gln Ala Asp Ser Ala
        35                  40                  45              
Arg Pro Glu Gln Ser Ser Gln Ser Pro Val Gln Ala Val Pro Gly Ser
    50                  55                  60                  
Gly Asp Ser Gln Pro Asp Asp Pro Pro Asp Arg Gly Thr Gly Leu Ser
65                  70                  75                  80  
Ala Ser Gln Arg Ala Ser Gln Asp His Leu Ser Glu Gln Gly Ala Asp
                85                  90                  95      
Asp Ser Lys Pro Glu Thr Asp Arg Val Pro Gly Asp Gly Gly Gln Lys
            100                 105                 110         
Glu His Leu Pro Ser Ile Asp Ser Glu Gly Glu Lys Pro Asp Arg Gly
        115                 120                 125             
Ala Pro Gln Glu Gly Gly Ala Gln Arg Thr Ala Gly Ala Gly Leu Pro
    130                 135                 140                 
Arg Gly Pro Gln Glu Glu Gly Asp Gly Val Pro Cys Thr Pro Ala Ser
145                 150                 155                 160 
Ala Pro Thr Ser Gly Pro Ala Pro Gly Leu Gly Pro Ala Ser Trp Cys
                165                 170                 175     
Leu Glu Pro Gly Ser Val Ala Gln Gly Ser Pro Asp Pro Gln Gln Thr
            180                 185                 190         
Pro Ser Arg Met Gly Arg Glu Gly Glu Gly Thr His Ser Ser Leu Gly
        195                 200                 205             
Cys Ser Ser Leu Gly Met Val Val Ile Ala Asp Leu Ser Thr Asp Pro
    210                 215                 220                 
Thr Glu Leu Glu Glu Arg Ala Leu Glu Val Ala Gly Pro Asp Gly Gln
225                 230                 235                 240 
Ala Ser Ala Ile Ser Pro Ala Ser Pro Arg Arg Lys Ala Ala Asp Gly
                245                 250                 255     
Gly His Arg Arg Ala Leu Pro Gly Cys Thr Ser Leu Thr Gly Glu Thr
            260                 265                 270         
Thr Gly Glu Ser Gly Glu Ala Gly Gln Asp Gly Lys Pro Pro Gly Asp
        275                 280                 285             
Val Leu Val Gly Pro Thr Ala Ser Leu Ala Leu Ala Pro Gly Ser Gly
    290                 295                 300                 
Glu Ser Met Met Gly Ala Gly Asp Ser Gly His Ala Ser Pro Asp Thr
305                 310                 315                 320 
Gly Pro Cys Val Asn Gln Lys Gln Glu Pro Gly Pro Ala Gln Glu Glu
                325                 330                 335     
Ala Glu Leu Gly Gly Gln Asn Leu Glu Arg Asp Leu Glu Gly Phe Arg
            340                 345                 350         
Val Ser Pro Gln Ala Ser Val Val Leu Glu His Arg Glu Ile Ala Asp
        355                 360                 365             
Asp Pro Leu Gln Glu Pro Gly Ala Gln Arg Gly Ile Pro Asp Thr Thr
    370                 375                 380                 
Ser Glu Leu Ala Gly Gln Arg Asp His Leu Pro His Ser Ala Asp Gln
385                 390                 395                 400 
Gly Thr Trp Ala Asp Ser Leu Ala Val Glu Leu Asp Phe Leu Leu Asp
                405                 410                 415     
Ser Gln Ile Gln Asp Ala Leu Asp Ala Ser Asp Phe Glu Ala Pro Pro
            420                 425                 430         
Glu Gln Leu Phe Pro Ser Gly Asn Lys Pro Gly Pro Cys Trp Pro Gly
        435                 440                 445             
Pro Ser Ser His Ala Asn Gly Asp Pro Val Ala Val Ala Lys Ala Gln
    450                 455                 460                 
Pro Arg Thr Phe Val Gly Ile Gln Ala Ser Glu Ala Ser Arg Met Glu
465                 470                 475                 480 
Asp Ala Thr Asn Val Val Arg Gly Leu Ile Val Glu Leu Ser Asn Leu
                485                 490                 495     
Asn Arg Leu Ile Met Gly Thr His Arg Asp Leu Glu Ala Phe Lys Arg
            500                 505                 510         
Leu Asn Tyr Arg Lys Thr Lys Leu Gly Gly Lys Ala Pro Leu Pro Tyr
        515                 520                 525             
Pro Ser Lys Gly Pro Gly Asn Ile Pro Arg Gly Asp Pro Pro Trp Arg
    530                 535                 540                 
Glu Leu
545     

