                         SEQUENCE LISTING

<110>  Krautwald, Stefan
       Kunzendorf, Ulrich
 
<120>  Anti-Apoptotic Fusion Proteins

<130>  P 81499

<160>  7     

<170>  PatentIn version 3.4

<210>  1
<211>  344
<212>  PRT
<213>  Cowpox virus

<400>  1

Met Asp Ile Phe Arg Glu Ile Ala Ser Ser Met Lys Gly Glu Asn Val 
1               5                   10                  15      


Phe Ile Ser Pro Ala Ser Ile Ser Ser Val Leu Thr Ile Leu Tyr Tyr 
            20                  25                  30          


Gly Ala Asn Gly Ser Thr Ala Glu Gln Leu Ser Lys Tyr Val Glu Lys 
        35                  40                  45              


Glu Ala Asp Lys Asn Lys Val Ser Ala Gln Cys Ile Ser Phe Lys Ser 
    50                  55                  60                  


Met Asn Lys Val Tyr Gly Arg Tyr Ser Ala Val Phe Lys Asp Ser Phe 
65                  70                  75                  80  


Leu Gly Lys Ile Gly Asp Lys Phe Gln Thr Val Asp Phe Thr Asp Cys 
                85                  90                  95      


Arg Thr Ile Asp Ala Ile Asn Lys Cys Val Asp Ile Phe Thr Gly Gly 
            100                 105                 110         


Lys Ile Asn Pro Leu Leu Asp Glu Pro Leu Ser Pro Asp Thr Cys Leu 
        115                 120                 125             


Leu Ala Ile Ser Ala Val Tyr Phe Lys Ala Lys Trp Leu Met Pro Phe 
    130                 135                 140                 


Glu Lys Glu Phe Thr Ser Asp Tyr Pro Phe Tyr Val Ser Pro Thr Glu 
145                 150                 155                 160 


Met Val Asp Val Ser Met Met Ser Met Tyr Gly Glu Pro Phe Asn His 
                165                 170                 175     


Ala Ser Val Lys Glu Ser Phe Gly Asn Phe Ser Ile Ile Glu Leu Pro 
            180                 185                 190         


Tyr Val Gly Asp Thr Ser Met Met Val Ile Leu Pro Asp Lys Ile Asp 
        195                 200                 205             


Gly Leu Glu Ser Ile Glu Gln Asn Leu Thr Asp Thr Asn Phe Lys Lys 
    210                 215                 220                 


Trp Cys Asn Ser Leu Glu Ala Thr Phe Ile Asp Val His Ile Pro Lys 
225                 230                 235                 240 


Phe Lys Val Thr Gly Ser Tyr Asn Leu Val Asp Thr Leu Val Lys Leu 
                245                 250                 255     


Gly Leu Thr Asp Val Phe Tyr Ser Thr Gly Asp Tyr Ser Asn Met Cys 
            260                 265                 270         


Asn Ser Asp Val Ser Val Asp Ala Met Ile His Lys Thr Tyr Ile Asp 
        275                 280                 285             


Val Asn Glu Glu Tyr Thr Glu Ala Ala Ala Ala Thr Ser Val Leu Val 
    290                 295                 300                 


Ala Asp Cys Ala Ser Thr Val Thr Asn Glu Phe Cys Ala Asp His Pro 
305                 310                 315                 320 


Phe Ile Tyr Val Ile Arg His Val Asp Gly Lys Ile Leu Phe Val Gly 
                325                 330                 335     


Arg Tyr Cys Ser Pro Thr Thr Asn 
            340                 


<210>  2
<211>  341
<212>  PRT
<213>  cowpox virus

<400>  2

Met Asp Ile Phe Arg Glu Ile Ala Ser Ser Met Lys Gly Glu Asn Val 
1               5                   10                  15      


Phe Ile Ser Pro Pro Ser Ile Ser Ser Val Leu Thr Ile Leu Tyr Tyr 
            20                  25                  30          


Gly Ala Asn Gly Ser Thr Ala Glu Gln Leu Ser Lys Tyr Val Glu Lys 
        35                  40                  45              


Glu Ala Asp Lys Asn Lys Asp Asp Ile Ser Phe Lys Ser Met Asn Lys 
    50                  55                  60                  


Val Tyr Gly Arg Tyr Ser Ala Val Phe Lys Asp Ser Phe Leu Arg Lys 
65                  70                  75                  80  


Ile Gly Asp Asn Phe Gln Thr Val Asp Phe Thr Asp Cys Arg Thr Val 
                85                  90                  95      


Asp Ala Ile Asn Lys Cys Val Asp Ile Phe Thr Glu Gly Lys Ile Asn 
            100                 105                 110         


Pro Leu Leu Asp Glu Pro Leu Ser Pro Asp Thr Cys Leu Leu Ala Ile 
        115                 120                 125             


Ser Ala Val Tyr Phe Lys Ala Lys Trp Leu Met Pro Phe Glu Lys Glu 
    130                 135                 140                 


Phe Thr Ser Asp Tyr Pro Phe Tyr Val Ser Pro Thr Glu Met Val Asp 
145                 150                 155                 160 


Val Ser Met Met Ser Met Tyr Gly Glu Ala Phe Asn His Ala Ser Val 
                165                 170                 175     


Lys Glu Ser Phe Gly Asn Phe Ser Ile Ile Glu Leu Pro Tyr Val Gly 
            180                 185                 190         


Asp Thr Ser Met Val Val Ile Leu Pro Asp Asn Ile Asp Gly Leu Glu 
        195                 200                 205             


Ser Ile Glu Gln Asn Leu Thr Asp Thr Asn Phe Lys Lys Trp Cys Asp 
    210                 215                 220                 


Ser Met Asp Ala Met Phe Ile Asp Val His Ile Pro Lys Phe Lys Val 
225                 230                 235                 240 


Thr Gly Ser Tyr Asn Leu Val Asp Ala Leu Val Lys Leu Gly Leu Thr 
                245                 250                 255     


Glu Val Phe Gly Ser Thr Gly Asp Tyr Ser Asn Met Cys Asn Ser Asp 
            260                 265                 270         


Val Ser Val Asp Ala Met Ile His Lys Thr Tyr Ile Asp Val Asn Glu 
        275                 280                 285             


Glu Tyr Thr Glu Ala Ala Ala Ala Thr Cys Ala Leu Val Ala Asp Cys 
    290                 295                 300                 


Ala Ser Thr Val Thr Asn Glu Phe Cys Ala Asp His Pro Phe Ile Tyr 
305                 310                 315                 320 


Val Ile Arg His Val Asp Gly Lys Ile Leu Phe Val Gly Arg Tyr Cys 
                325                 330                 335     


Ser Pro Thr Thr Asn 
            340     


<210>  3
<211>  11
<212>  PRT
<213>  HI virus type 1

<400>  3

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  4
<211>  401
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein PTD-CrmA


<220>
<221>  misc_feature
<222>  (267)..(267)
<223>  Xaa can be any naturally occurring amino acid

<400>  4

Met Arg Gly Ser His His His His His His Gly Met Ala Ser Met Thr 
1               5                   10                  15      


Gly Gly Gln Gln Met Gly Arg Asp Leu Tyr Asp Asp Asp Asp Lys Asp 
            20                  25                  30          


Arg Trp Gly Ser Lys Leu Gly Tyr Gly Arg Lys Lys Arg Arg Gln Arg 
        35                  40                  45              


Arg Arg Gly Gly Ser Thr Met Ala Gly Thr Asp Ile Phe Arg Glu Ile 
    50                  55                  60                  


Ala Ser Ser Met Lys Gly Glu Asn Val Phe Ile Ser Pro Ala Ser Ile 
65                  70                  75                  80  


Ser Ser Val Leu Thr Ile Leu Tyr Tyr Gly Ala Asn Gly Ser Thr Ala 
                85                  90                  95      


Glu Gln Leu Ser Lys Tyr Val Glu Lys Glu Ala Asp Lys Asn Lys Val 
            100                 105                 110         


Ser Ala Gln Cys Ile Ser Phe Lys Ser Met Asn Lys Val Tyr Gly Arg 
        115                 120                 125             


Tyr Ser Ala Val Phe Lys Asp Ser Phe Leu Gly Lys Ile Gly Asp Lys 
    130                 135                 140                 


Phe Gln Thr Val Asp Phe Thr Asp Cys Arg Thr Ile Asp Ala Ile Asn 
145                 150                 155                 160 


Lys Cys Val Asp Ile Phe Thr Gly Gly Lys Ile Asn Pro Leu Leu Asp 
                165                 170                 175     


Glu Pro Leu Ser Pro Asp Thr Cys Leu Leu Ala Ile Ser Ala Val Tyr 
            180                 185                 190         


Phe Lys Ala Lys Trp Leu Met Pro Phe Glu Lys Glu Phe Thr Ser Asp 
        195                 200                 205             


Tyr Pro Phe Tyr Val Ser Pro Thr Glu Met Val Asp Val Ser Met Met 
    210                 215                 220                 


Ser Met Tyr Gly Glu Pro Phe Asn His Ala Ser Val Lys Glu Ser Phe 
225                 230                 235                 240 


Gly Asn Phe Ser Ile Ile Glu Leu Pro Tyr Val Gly Asp Thr Ser Met 
                245                 250                 255     


Met Val Ile Leu Pro Asp Lys Ile Asp Gly Xaa Glu Ser Ile Glu Gln 
            260                 265                 270         


Asn Leu Thr Asp Thr Asn Phe Lys Lys Trp Cys Asn Ser Leu Glu Ala 
        275                 280                 285             


Thr Phe Ile Asp Val His Ile Pro Lys Phe Lys Val Thr Gly Ser Tyr 
    290                 295                 300                 


Asn Leu Val Asp Thr Leu Val Lys Leu Gly Leu Thr Asp Val Phe Tyr 
305                 310                 315                 320 


Ser Thr Gly Asp Tyr Ser Asn Met Cys Asn Ser Asp Val Ser Val Asp 
                325                 330                 335     


Ala Met Ile His Lys Thr Tyr Ile Asp Val Asn Glu Glu Tyr Thr Glu 
            340                 345                 350         


Ala Ala Ala Ala Thr Ser Val Leu Val Ala Asp Cys Ala Ser Thr Val 
        355                 360                 365             


Thr Asn Glu Phe Cys Ala Asp His Pro Phe Ile Tyr Val Ile Arg His 
    370                 375                 380                 


Val Asp Gly Lys Ile Leu Phe Val Gly Arg Tyr Cys Ser Pro Thr Thr 
385                 390                 395                 400 


Asn 
    


<210>  5
<211>  1206
<212>  DNA
<213>  Artificial

<220>
<223>  DNA Encoding fusion protein PTD-CrmA

<400>  5
atgcggggtt ctcatcatca tcatcatcat ggtatggcta gcatgactgg tggacagcaa     60

atgggtcggg atctgtacga cgatgacgat aaggatcgat ggggatccaa gcttggctac    120

ggccgcaaga aacgccgcca gcgccgccgc ggtggatcca ccatggccgg taccgatatc    180

ttcagggaaa tcgcatcttc tatgaaagga gagaatgtat tcatttctcc agcgtcaatc    240

tcgtcagtat tgacaatact gtattatgga gctaatggat ccactgctga acagctatca    300

aaatatgtag aaaaggaggc ggacaagaat aaggttagcg ctcagtgtat ctcattcaag    360

tccatgaata aagtatatgg gcgatattct gccgtgttta aagattcctt tttgggaaaa    420

attggcgata agtttcaaac tgttgacttc actgattgtc gcactataga tgcaatcaac    480

aagtgtgtag atatctttac tggtgggaaa atcaatccac tattggatga accattgtct    540

cctgatacct gtctcctagc aattagtgcc gtatacttta aagcaaaatg gttgatgcca    600

ttcgaaaagg aattcaccag tgattatcca ttttacgtat caccgacgga aatggtagac    660

gtaagtatga tgtctatgta cggcgagcca tttaatcacg catctgtaaa agaatcattc    720

ggtaactttt caatcataga actgccatat gttggagata ctagtatgat ggtcattctt    780

ccagacaaga ttgatggatt rgaatccata gaacaaaatc taacagatac aaatttcaag    840

aaatggtgta actctctgga agctacgttt atcgatgtac atattcccaa gtttaaggta    900

acaggctcgt ataatcttgt ggatacgcta gtaaagttgg gactgacaga tgtgttctat    960

tcaaccggcg attatagcaa tatgtgtaat tcagatgtga gtgtcgacgc tatgatacac   1020

aaaacgtata tagatgtcaa tgaagagtat acagaagcag ctgcagcaac ttctgtacta   1080

gtggcagact gtgcatcaac agttacaaat gagttctgtg cagatcatcc gttcatctat   1140

gtgattaggc atgttgatgg caaaattctt ttcgttggta ggtattgctc tccaacaact   1200

aattaa                                                              1206


<210>  6
<211>  32
<212>  DNA
<213>  artificial

<220>
<223>  PCR primer

<400>  6
ccgggtaccg atatcttcag ggaaatcgca tc                                   32


<210>  7
<211>  37
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  7
ccggaattct taattagttg ttggagagca atatcta                              37


