                         	SEQUENCE LISTING

<110>  CENTRE HOSPITALIER UNIVERSITAIRE SAINTE-JUSTINE
       UNIVERSIT DE MONTRAL
       CENTRE HOSPITALIER DE LUNIVERSIT DE MONTRAL
 
<120>  SYNGAP1 DYSFUNCTIONS AND USES THEREOF IN DIAGNOSTIC AND 
       THERAPEUTIC APPLICATIONS FOR MENTAL RETARDATION

<130>  276486.4

<150>  US 61/112,345
<151>  2008-11-07

<160>  56    

<170>  PatentIn version 3.4

<210>  1
<211>  6011
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (196)..(4227)

<400>  1
tctcggctgc cgctgctgcc gttggctctt attctcctcc tcctcctcct ctctcctcct     60

ctctgcttct ctctgctcct ctctcctcct ctctcctcct cctcctcctc cacctcctcc    120

tccttctccc cctctttctc cccctctttc tctcttcttt ctcccccgtc cccccgcccc    180

ctccccccag gcctg atg agc agg tct cga gcc tcc atc cat cgg ggg agc     231
                 Met Ser Arg Ser Arg Ala Ser Ile His Arg Gly Ser        
                 1               5                   10                 

atc ccc gcg atg tcc tat gcc ccc ttc aga gat gta cgg gga ccc tct      279
Ile Pro Ala Met Ser Tyr Ala Pro Phe Arg Asp Val Arg Gly Pro Ser         
        15                  20                  25                      

atg cac cga acc caa tac gtt cat tcc ccg tat gat cgt cct ggt tgg      327
Met His Arg Thr Gln Tyr Val His Ser Pro Tyr Asp Arg Pro Gly Trp         
    30                  35                  40                          

aac cct cgg ttc tgc atc atc tcg ggg aac cag ctg ctc atg ctg gat      375
Asn Pro Arg Phe Cys Ile Ile Ser Gly Asn Gln Leu Leu Met Leu Asp         
45                  50                  55                  60          

gag gat gag ata cac ccc cta ctg atc cgg gac cgg agg agc gag tcc      423
Glu Asp Glu Ile His Pro Leu Leu Ile Arg Asp Arg Arg Ser Glu Ser         
                65                  70                  75              

agt cgc aac aaa ctg ctg aga cgc aca gtc tcc gtg ccg gtg gag ggg      471
Ser Arg Asn Lys Leu Leu Arg Arg Thr Val Ser Val Pro Val Glu Gly         
            80                  85                  90                  

cgg ccc cac ggc gag cat gaa tac cac ttg ggt cgc tcg agg agg aag      519
Arg Pro His Gly Glu His Glu Tyr His Leu Gly Arg Ser Arg Arg Lys         
        95                  100                 105                     

agt gtc cca ggg ggg aag cag tac agc atg gag ggt gcc cct gct gcg      567
Ser Val Pro Gly Gly Lys Gln Tyr Ser Met Glu Gly Ala Pro Ala Ala         
    110                 115                 120                         

ccc ttc cgg ccc tcg caa ggc ttc ctg agc cga cgg cta aaa agc tcc      615
Pro Phe Arg Pro Ser Gln Gly Phe Leu Ser Arg Arg Leu Lys Ser Ser         
125                 130                 135                 140         

atc aaa cga acg aag tca caa ccc aaa ctt gac cgg acc agc agc ttt      663
Ile Lys Arg Thr Lys Ser Gln Pro Lys Leu Asp Arg Thr Ser Ser Phe         
                145                 150                 155             

cgc cag atc ctg cct cgc ttc cga agt gct gac cat gac cgg gcc cgg      711
Arg Gln Ile Leu Pro Arg Phe Arg Ser Ala Asp His Asp Arg Ala Arg         
            160                 165                 170                 

ctg atg caa agc ttt aag gag tca cac tct cat gag tcc ttg ctg agt      759
Leu Met Gln Ser Phe Lys Glu Ser His Ser His Glu Ser Leu Leu Ser         
        175                 180                 185                     

cct agc agt gca gct gag gca ttg gag ctc aac ttg gat gaa gat tcc      807
Pro Ser Ser Ala Ala Glu Ala Leu Glu Leu Asn Leu Asp Glu Asp Ser         
    190                 195                 200                         

att atc aag cca gtg cac agc tcc atc ctg ggc cag gag ttc tgt ttt      855
Ile Ile Lys Pro Val His Ser Ser Ile Leu Gly Gln Glu Phe Cys Phe         
205                 210                 215                 220         

gag gta aca act tca tca gga aca aaa tgc ttt gcc tgt cgg tct gcg      903
Glu Val Thr Thr Ser Ser Gly Thr Lys Cys Phe Ala Cys Arg Ser Ala         
                225                 230                 235             

gcc gaa aga gac aaa tgg att gag aat ctg cag cgg gca gta aag ccc      951
Ala Glu Arg Asp Lys Trp Ile Glu Asn Leu Gln Arg Ala Val Lys Pro         
            240                 245                 250                 

aac aag gac aac agc cgc cgg gta gac aat gtg cta aag ctg tgg atc      999
Asn Lys Asp Asn Ser Arg Arg Val Asp Asn Val Leu Lys Leu Trp Ile         
        255                 260                 265                     

ata gag gcc cgg gag ctg ccc ccc aag aag cgg tac tac tgt gag ctc     1047
Ile Glu Ala Arg Glu Leu Pro Pro Lys Lys Arg Tyr Tyr Cys Glu Leu         
    270                 275                 280                         

tgc ctg gat gac atg ctg tat gca cgc acc acc tcc aag ccc cgc tct     1095
Cys Leu Asp Asp Met Leu Tyr Ala Arg Thr Thr Ser Lys Pro Arg Ser         
285                 290                 295                 300         

gcc tct ggg gac acc gtc ttc tgg ggc gag cac ttc gag ttt aac aac     1143
Ala Ser Gly Asp Thr Val Phe Trp Gly Glu His Phe Glu Phe Asn Asn         
                305                 310                 315             

ctg ccg gct gtc cgt gcc ctg cgg ctg cat ctg tac cgt gac tca gac     1191
Leu Pro Ala Val Arg Ala Leu Arg Leu His Leu Tyr Arg Asp Ser Asp         
            320                 325                 330                 

aaa aag cgc aag aag gac aag gca ggc tat gtc ggc ctg gtg act gtg     1239
Lys Lys Arg Lys Lys Asp Lys Ala Gly Tyr Val Gly Leu Val Thr Val         
        335                 340                 345                     

cca gtg gcc acc ctg gct ggg cgc cac ttc aca gag cag tgg tac cct     1287
Pro Val Ala Thr Leu Ala Gly Arg His Phe Thr Glu Gln Trp Tyr Pro         
    350                 355                 360                         

gta acc ctg cca aca ggc agt ggg gga tct ggg ggc atg ggt tcg gga     1335
Val Thr Leu Pro Thr Gly Ser Gly Gly Ser Gly Gly Met Gly Ser Gly         
365                 370                 375                 380         

ggg gga ggg ggc tcg ggg ggt ggc tca ggg ggc aag ggc aaa gga ggt     1383
Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Lys Gly Lys Gly Gly         
                385                 390                 395             

tgc ccg gct gtg cgg ctg aaa gca cgt tac cag aca atg agc atc ttg     1431
Cys Pro Ala Val Arg Leu Lys Ala Arg Tyr Gln Thr Met Ser Ile Leu         
            400                 405                 410                 

ccc atg gag cta tat aaa gag ttt gca gag tat gtc acc aac cat tat     1479
Pro Met Glu Leu Tyr Lys Glu Phe Ala Glu Tyr Val Thr Asn His Tyr         
        415                 420                 425                     

cgg atg ctg tgt gca gtc ttg gag ccc gcc ctg aat gtc aaa ggc aag     1527
Arg Met Leu Cys Ala Val Leu Glu Pro Ala Leu Asn Val Lys Gly Lys         
    430                 435                 440                         

gag gag gtt gcc agt gca cta gtt cac atc ctg cag agt aca ggc aag     1575
Glu Glu Val Ala Ser Ala Leu Val His Ile Leu Gln Ser Thr Gly Lys         
445                 450                 455                 460         

gcc aag gac ttc ctt tca gac atg gcc atg tct gag gta gac cgg ttc     1623
Ala Lys Asp Phe Leu Ser Asp Met Ala Met Ser Glu Val Asp Arg Phe         
                465                 470                 475             

atg gaa cgg gag cac ctc ata ttc cgc gag aac acg ctt gcc act aaa     1671
Met Glu Arg Glu His Leu Ile Phe Arg Glu Asn Thr Leu Ala Thr Lys         
            480                 485                 490                 

gcc ata gaa gag tat atg aga ctg att ggt cag aaa tac ctc aag gat     1719
Ala Ile Glu Glu Tyr Met Arg Leu Ile Gly Gln Lys Tyr Leu Lys Asp         
        495                 500                 505                     

gcc att gga gaa ttc atc cgt gct ctg tat gaa tct gag gaa aac tgc     1767
Ala Ile Gly Glu Phe Ile Arg Ala Leu Tyr Glu Ser Glu Glu Asn Cys         
    510                 515                 520                         

gag gta gac cct atc aag tgc aca gca tcc agt ttg gca gag cac cag     1815
Glu Val Asp Pro Ile Lys Cys Thr Ala Ser Ser Leu Ala Glu His Gln         
525                 530                 535                 540         

gcc aac ctg cga atg tgc tgt gag ttg gcc ctg tgc aag gtg gtc aac     1863
Ala Asn Leu Arg Met Cys Cys Glu Leu Ala Leu Cys Lys Val Val Asn         
                545                 550                 555             

tcc cac tgc gtg ttc ccg agg gag ctg aag gag gtg ttt gct tcg tgg     1911
Ser His Cys Val Phe Pro Arg Glu Leu Lys Glu Val Phe Ala Ser Trp         
            560                 565                 570                 

cgg ctg cgc tgc gca gag cga ggc cgg gag gac atc gca gac agg ctt     1959
Arg Leu Arg Cys Ala Glu Arg Gly Arg Glu Asp Ile Ala Asp Arg Leu         
        575                 580                 585                     

atc agc gcc tca ctc ttc ctg cgc ttc ctc tgc cca gcg att atg tcg     2007
Ile Ser Ala Ser Leu Phe Leu Arg Phe Leu Cys Pro Ala Ile Met Ser         
    590                 595                 600                         

ccc agt ctc ttt ggg ctt atg cag gag tac cca gat gag cag acc tca     2055
Pro Ser Leu Phe Gly Leu Met Gln Glu Tyr Pro Asp Glu Gln Thr Ser         
605                 610                 615                 620         

cga acc ctc acc ctc att gcc aag gtc atc cag aac ctg gcc aac ttt     2103
Arg Thr Leu Thr Leu Ile Ala Lys Val Ile Gln Asn Leu Ala Asn Phe         
                625                 630                 635             

tcc aag ttt acc tca aag gag gac ttt ctg ggc ttc atg aat gag ttt     2151
Ser Lys Phe Thr Ser Lys Glu Asp Phe Leu Gly Phe Met Asn Glu Phe         
            640                 645                 650                 

ctg gag ctg gaa tgg ggt tcc atg cag cag ttt ttg tat gag atc tcc     2199
Leu Glu Leu Glu Trp Gly Ser Met Gln Gln Phe Leu Tyr Glu Ile Ser         
        655                 660                 665                     

aat ctg gac acg cta acc aac agc agt agc ttt gag ggt tac atc gac     2247
Asn Leu Asp Thr Leu Thr Asn Ser Ser Ser Phe Glu Gly Tyr Ile Asp         
    670                 675                 680                         

ttg ggc cga gag ctc tcc aca ctg cat gcc cta ctc tgg gag gtg ctg     2295
Leu Gly Arg Glu Leu Ser Thr Leu His Ala Leu Leu Trp Glu Val Leu         
685                 690                 695                 700         

ccc cag ctc agc aag gaa gcc ctc ctg aag ctg ggt cca ctg ccc cgg     2343
Pro Gln Leu Ser Lys Glu Ala Leu Leu Lys Leu Gly Pro Leu Pro Arg         
                705                 710                 715             

ctc ctc aac gac atc agc aca gct ctg agg aac ccc aac atc caa agg     2391
Leu Leu Asn Asp Ile Ser Thr Ala Leu Arg Asn Pro Asn Ile Gln Arg         
            720                 725                 730                 

cag cca agc cgc cag agt gag cgg ccc cgg cct cag cct gtg gta ctg     2439
Gln Pro Ser Arg Gln Ser Glu Arg Pro Arg Pro Gln Pro Val Val Leu         
        735                 740                 745                     

cgg ggg cca tcg gct gag atg cag ggc tac atg atg cgg gac ctc aac     2487
Arg Gly Pro Ser Ala Glu Met Gln Gly Tyr Met Met Arg Asp Leu Asn         
    750                 755                 760                         

agc tcc atc gac ctt cag tcc ttc atg gct cga ggc ctc aac agc tct     2535
Ser Ser Ile Asp Leu Gln Ser Phe Met Ala Arg Gly Leu Asn Ser Ser         
765                 770                 775                 780         

atg gac atg gct cgc ctc ccc tcc cca acc aag gaa aag cca ccc cca     2583
Met Asp Met Ala Arg Leu Pro Ser Pro Thr Lys Glu Lys Pro Pro Pro         
                785                 790                 795             

cca ccg cct ggt ggt ggt aaa gac ctg ttc tat gta agc cgt cca ccc     2631
Pro Pro Pro Gly Gly Gly Lys Asp Leu Phe Tyr Val Ser Arg Pro Pro         
            800                 805                 810                 

ctg gcc cgt tcc tca cca gca tac tgc acg agc agc tcg gac atc aca     2679
Leu Ala Arg Ser Ser Pro Ala Tyr Cys Thr Ser Ser Ser Asp Ile Thr         
        815                 820                 825                     

gag cca gag cag aag atg ctg agt gtc aac aag agt gtg tcc atg ctg     2727
Glu Pro Glu Gln Lys Met Leu Ser Val Asn Lys Ser Val Ser Met Leu         
    830                 835                 840                         

gac tta cag ggt gat ggg cct ggt ggc cgc ctc aac agc agc agt gtt     2775
Asp Leu Gln Gly Asp Gly Pro Gly Gly Arg Leu Asn Ser Ser Ser Val         
845                 850                 855                 860         

tcg aac ctg gcg gcc gta ggg gac ctg ctg cac tca agc cag gcc tcg     2823
Ser Asn Leu Ala Ala Val Gly Asp Leu Leu His Ser Ser Gln Ala Ser         
                865                 870                 875             

ctg aca gca gcc ttg ggg cta cgg cct gcg cct gcc gga cgc ctc tcc     2871
Leu Thr Ala Ala Leu Gly Leu Arg Pro Ala Pro Ala Gly Arg Leu Ser         
            880                 885                 890                 

cag ggg agt ggc tca tcc atc acg gcg gct ggc atg cgc ctc agc cag     2919
Gln Gly Ser Gly Ser Ser Ile Thr Ala Ala Gly Met Arg Leu Ser Gln         
        895                 900                 905                     

atg ggt gtc acc aca gac ggt gtc cct gcc cag caa ctg cga atc ccc     2967
Met Gly Val Thr Thr Asp Gly Val Pro Ala Gln Gln Leu Arg Ile Pro         
    910                 915                 920                         

ctc tcc ttc cag aac cct ctc ttc cac atg gct gct gat ggg cca ggt     3015
Leu Ser Phe Gln Asn Pro Leu Phe His Met Ala Ala Asp Gly Pro Gly         
925                 930                 935                 940         

ccc cca ggc ggc cat gga ggg ggc ggt ggc cat ggc cca cct tcc tcc     3063
Pro Pro Gly Gly His Gly Gly Gly Gly Gly His Gly Pro Pro Ser Ser         
                945                 950                 955             

cat cac cac cac cac cac cat cac cac cac cga ggt gga gag ccc cct     3111
His His His His His His His His His His Arg Gly Gly Glu Pro Pro         
            960                 965                 970                 

ggg gac acc ttt gcc cca ttc cat ggc tat agc aag agt gag gac ctc     3159
Gly Asp Thr Phe Ala Pro Phe His Gly Tyr Ser Lys Ser Glu Asp Leu         
        975                 980                 985                     

tct tcc ggg gtc ccc aag ccc cct gct gcc tcc atc  ctt cat agc cac    3207
Ser Ser Gly Val Pro Lys Pro Pro Ala Ala Ser Ile  Leu His Ser His        
    990                 995                 1000                        

agc  tac agt gat gag ttt  gga ccc tct ggc act  gac ttc acc cgt      3252
Ser  Tyr Ser Asp Glu Phe  Gly Pro Ser Gly Thr  Asp Phe Thr Arg          
1005                 1010                 1015                          

cgg  cag ctt tca ctc cag  gac aac ctg cag cac  atg ctg tcc cct      3297
Arg  Gln Leu Ser Leu Gln  Asp Asn Leu Gln His  Met Leu Ser Pro          
1020                 1025                 1030                          

ccc  cag atc acc att ggt  ccc cag agg cca gcc  ccc tca ggg cct      3342
Pro  Gln Ile Thr Ile Gly  Pro Gln Arg Pro Ala  Pro Ser Gly Pro          
1035                 1040                 1045                          

gga  ggt ggg agc ggt ggg  ggc agc ggt ggg ggt  ggc ggg ggc cag      3387
Gly  Gly Gly Ser Gly Gly  Gly Ser Gly Gly Gly  Gly Gly Gly Gln          
1050                 1055                 1060                          

ccg  cct cca ttg cag agg  ggc aag tct cag cag  ttg aca gtc agc      3432
Pro  Pro Pro Leu Gln Arg  Gly Lys Ser Gln Gln  Leu Thr Val Ser          
1065                 1070                 1075                          

gca  gcc cag aaa ccc cgg  cca tcc agc ggg aat  cta ttg cag tcc      3477
Ala  Ala Gln Lys Pro Arg  Pro Ser Ser Gly Asn  Leu Leu Gln Ser          
1080                 1085                 1090                          

cca  gag cca agt tat ggc  ccc gcc cgt cca cgg  caa cag agc ctc      3522
Pro  Glu Pro Ser Tyr Gly  Pro Ala Arg Pro Arg  Gln Gln Ser Leu          
1095                 1100                 1105                          

agc  aag gag ggc agc att  ggg ggc agc ggg ggc  agc ggt ggc gga      3567
Ser  Lys Glu Gly Ser Ile  Gly Gly Ser Gly Gly  Ser Gly Gly Gly          
1110                 1115                 1120                          

ggg  ggt ggg ggg ctg aag  ccc tcc atc acc aag  cag cat tct cag      3612
Gly  Gly Gly Gly Leu Lys  Pro Ser Ile Thr Lys  Gln His Ser Gln          
1125                 1130                 1135                          

aca  cca tcc aca ttg aac  ccc aca atg cca gcc  tct gag cgg aca      3657
Thr  Pro Ser Thr Leu Asn  Pro Thr Met Pro Ala  Ser Glu Arg Thr          
1140                 1145                 1150                          

gtg  gcc tgg gtc tcc aac  atg cct cac ctg tcg  gct gac atc gag      3702
Val  Ala Trp Val Ser Asn  Met Pro His Leu Ser  Ala Asp Ile Glu          
1155                 1160                 1165                          

agt  gcc cac atc gag cgg  gaa gag tac aag ctc  aag gag tac tca      3747
Ser  Ala His Ile Glu Arg  Glu Glu Tyr Lys Leu  Lys Glu Tyr Ser          
1170                 1175                 1180                          

aaa  tcg atg gat gag agc  cgg ctg gat agg gtg  aag gag tac gag      3792
Lys  Ser Met Asp Glu Ser  Arg Leu Asp Arg Val  Lys Glu Tyr Glu          
1185                 1190                 1195                          

gag  gag att cac tca ctg  aaa gag cgg ctg cac  atg tcc aac cgg      3837
Glu  Glu Ile His Ser Leu  Lys Glu Arg Leu His  Met Ser Asn Arg          
1200                 1205                 1210                          

aag  ctg gaa gag tat gag  cgg agg ctg ctg tcc  cag gaa gaa caa      3882
Lys  Leu Glu Glu Tyr Glu  Arg Arg Leu Leu Ser  Gln Glu Glu Gln          
1215                 1220                 1225                          

acc  agc aaa atc ctg atg  cag tat cag gcc cga  ctg gag cag agt      3927
Thr  Ser Lys Ile Leu Met  Gln Tyr Gln Ala Arg  Leu Glu Gln Ser          
1230                 1235                 1240                          

gag  aag agg cta agg cag  cag cag gca gag aag  gat tcc cag atc      3972
Glu  Lys Arg Leu Arg Gln  Gln Gln Ala Glu Lys  Asp Ser Gln Ile          
1245                 1250                 1255                          

aag  agc atc att ggc agg  ctg atg ctg gtg gag  gag gag ctg cgc      4017
Lys  Ser Ile Ile Gly Arg  Leu Met Leu Val Glu  Glu Glu Leu Arg          
1260                 1265                 1270                          

cgg  gac cac ccc gcc atg  gct gag ccg ctg cca  gaa ccc aag aag      4062
Arg  Asp His Pro Ala Met  Ala Glu Pro Leu Pro  Glu Pro Lys Lys          
1275                 1280                 1285                          

agg  ctg ctc gac gct cag  gag agg cag ctt ccc  ccc ttg ggt cca      4107
Arg  Leu Leu Asp Ala Gln  Glu Arg Gln Leu Pro  Pro Leu Gly Pro          
1290                 1295                 1300                          

aca  aac ccg cgt gtg acg  ctg gcc cca ccg tgg  aat ggc ctg gcc      4152
Thr  Asn Pro Arg Val Thr  Leu Ala Pro Pro Trp  Asn Gly Leu Ala          
1305                 1310                 1315                          

ccc  cca gcc cca cca ccc  cca ccc cgg ctg cag  att acg gag aac      4197
Pro  Pro Ala Pro Pro Pro  Pro Pro Arg Leu Gln  Ile Thr Glu Asn          
1320                 1325                 1330                          

ggc  gag ttc cga aac acc  gca gac cac tag cccacccagc atcagagacc     4247
Gly  Glu Phe Arg Asn Thr  Ala Asp His                                   
1335                 1340                                               

ttctcttcct ttcctgtgca ccccaccctg taacagcacc aaccaccagg attggacatc   4307

accgaggaac agcgggattg cctccccgaa tgcctccctg ggaggcacac tgattgccca   4367

cccccaccac tgcaccattt ccaggaggga gagtggggac cctcagccgc ccccttttcc   4427

ttcccattgg ggtgctgccc tctctttgac ccccagggac ccttgcccca ggacaccgcc   4487

taccccgtac agaccccttc actccggggt gctatcccca tcctctgcct catcgttccc   4547

ctgagcactg ggggacagac cctcaccccc accctggggg tgtggcacct ccaaactttc   4607

aacttcaggg tgattttttt agcagtaacc agagctgaca atctaactcc cctccaccgc   4667

cccattttgg cctcccctgc cccccttgtt atggggaggg gaccccgggt gagggggccc   4727

tattacccct tgatttctca ggagcgtctg ggggggctca gcacgcacaa actccttctc   4787

cttctaccac tcttaaattt actccctccc cacccagaac ccagatgggg tggagggggc   4847

caccggggca gggagggggc ggcaaggggg gaatgggagt tgtctcccct tctccccaca   4907

cctgatctgc tctcggctgg tcccagagcg gggtgagggg gcttatgccc ccccctcccc   4967

cagtgtgttg ggtggggtgg aattgaggtt agggtgaggg gtcagggttt aggagggtgt   5027

gtatgttggg aggacaggct agttgatctg tcctactctg acacacagtc ccctctgccc   5087

cttccttctc tcttcttggt ctctactccc agggggaggg gggaacttac tctaggaaaa   5147

gccatgtctc tctcccccag ggtgggggga cctgtgttgg aggaggggtg ttggggggcc   5207

cccttccatg actctgtccc ctgggggagg taggacaggg ctgggcttcc ctctcatcct   5267

ccccctccca atctccttcc acctccctcc ctcccgccag ctccacgatt tttcggtgtt   5327

tctctgtaca tagttttctg gcgggatagg ggaggtagga tggatggggt ttggggtggg   5387

taggccatgg gaggggagaa gcccctcctt ggcaccccct cttccctgac tgctgtcccc   5447

tacccagcct tgcccccttc atccttttgc gtttggtatt gagactctcc tagactctac   5507

tcctctttct tttgtatgga cagttcccct tcagtcccat ccccctacac atacacccag   5567

ccggggccaa atttatactt atataaaagt tgtaaatatg tgaaatttta tccctgtgcc   5627

ctttccccac ctcaggccct acccctggac cctccccaac cttccttctc tcttctttgg   5687

ctgttgtaat tatctggggt ttgtactgta catatccggg gtgtgtgtgt gtgggctggg   5747

ggcaaccctt ctgtacagag cttcctggcc ccctcccccc ccgcccctct gcttccctcc   5807

ccacccacca cctcaagggt agggagttgc tcttcctacc tgttttattt tgttttctcg   5867

ttctccctcc ccaccccact cccagcctta tctatccccc ctcactgtcc ccttttctcc   5927

actcccagcc ccatttcctt tttttctgga gtgtgtggtg aaacagaaaa aaacatgttt   5987

aataaacgga gattgttctt ttaa                                          6011


<210>  2
<211>  1343
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Arg Ser Arg Ala Ser Ile His Arg Gly Ser Ile Pro Ala Met 
1               5                   10                  15      


Ser Tyr Ala Pro Phe Arg Asp Val Arg Gly Pro Ser Met His Arg Thr 
            20                  25                  30          


Gln Tyr Val His Ser Pro Tyr Asp Arg Pro Gly Trp Asn Pro Arg Phe 
        35                  40                  45              


Cys Ile Ile Ser Gly Asn Gln Leu Leu Met Leu Asp Glu Asp Glu Ile 
    50                  55                  60                  


His Pro Leu Leu Ile Arg Asp Arg Arg Ser Glu Ser Ser Arg Asn Lys 
65                  70                  75                  80  


Leu Leu Arg Arg Thr Val Ser Val Pro Val Glu Gly Arg Pro His Gly 
                85                  90                  95      


Glu His Glu Tyr His Leu Gly Arg Ser Arg Arg Lys Ser Val Pro Gly 
            100                 105                 110         


Gly Lys Gln Tyr Ser Met Glu Gly Ala Pro Ala Ala Pro Phe Arg Pro 
        115                 120                 125             


Ser Gln Gly Phe Leu Ser Arg Arg Leu Lys Ser Ser Ile Lys Arg Thr 
    130                 135                 140                 


Lys Ser Gln Pro Lys Leu Asp Arg Thr Ser Ser Phe Arg Gln Ile Leu 
145                 150                 155                 160 


Pro Arg Phe Arg Ser Ala Asp His Asp Arg Ala Arg Leu Met Gln Ser 
                165                 170                 175     


Phe Lys Glu Ser His Ser His Glu Ser Leu Leu Ser Pro Ser Ser Ala 
            180                 185                 190         


Ala Glu Ala Leu Glu Leu Asn Leu Asp Glu Asp Ser Ile Ile Lys Pro 
        195                 200                 205             


Val His Ser Ser Ile Leu Gly Gln Glu Phe Cys Phe Glu Val Thr Thr 
    210                 215                 220                 


Ser Ser Gly Thr Lys Cys Phe Ala Cys Arg Ser Ala Ala Glu Arg Asp 
225                 230                 235                 240 


Lys Trp Ile Glu Asn Leu Gln Arg Ala Val Lys Pro Asn Lys Asp Asn 
                245                 250                 255     


Ser Arg Arg Val Asp Asn Val Leu Lys Leu Trp Ile Ile Glu Ala Arg 
            260                 265                 270         


Glu Leu Pro Pro Lys Lys Arg Tyr Tyr Cys Glu Leu Cys Leu Asp Asp 
        275                 280                 285             


Met Leu Tyr Ala Arg Thr Thr Ser Lys Pro Arg Ser Ala Ser Gly Asp 
    290                 295                 300                 


Thr Val Phe Trp Gly Glu His Phe Glu Phe Asn Asn Leu Pro Ala Val 
305                 310                 315                 320 


Arg Ala Leu Arg Leu His Leu Tyr Arg Asp Ser Asp Lys Lys Arg Lys 
                325                 330                 335     


Lys Asp Lys Ala Gly Tyr Val Gly Leu Val Thr Val Pro Val Ala Thr 
            340                 345                 350         


Leu Ala Gly Arg His Phe Thr Glu Gln Trp Tyr Pro Val Thr Leu Pro 
        355                 360                 365             


Thr Gly Ser Gly Gly Ser Gly Gly Met Gly Ser Gly Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Ser Gly Gly Lys Gly Lys Gly Gly Cys Pro Ala Val 
385                 390                 395                 400 


Arg Leu Lys Ala Arg Tyr Gln Thr Met Ser Ile Leu Pro Met Glu Leu 
                405                 410                 415     


Tyr Lys Glu Phe Ala Glu Tyr Val Thr Asn His Tyr Arg Met Leu Cys 
            420                 425                 430         


Ala Val Leu Glu Pro Ala Leu Asn Val Lys Gly Lys Glu Glu Val Ala 
        435                 440                 445             


Ser Ala Leu Val His Ile Leu Gln Ser Thr Gly Lys Ala Lys Asp Phe 
    450                 455                 460                 


Leu Ser Asp Met Ala Met Ser Glu Val Asp Arg Phe Met Glu Arg Glu 
465                 470                 475                 480 


His Leu Ile Phe Arg Glu Asn Thr Leu Ala Thr Lys Ala Ile Glu Glu 
                485                 490                 495     


Tyr Met Arg Leu Ile Gly Gln Lys Tyr Leu Lys Asp Ala Ile Gly Glu 
            500                 505                 510         


Phe Ile Arg Ala Leu Tyr Glu Ser Glu Glu Asn Cys Glu Val Asp Pro 
        515                 520                 525             


Ile Lys Cys Thr Ala Ser Ser Leu Ala Glu His Gln Ala Asn Leu Arg 
    530                 535                 540                 


Met Cys Cys Glu Leu Ala Leu Cys Lys Val Val Asn Ser His Cys Val 
545                 550                 555                 560 


Phe Pro Arg Glu Leu Lys Glu Val Phe Ala Ser Trp Arg Leu Arg Cys 
                565                 570                 575     


Ala Glu Arg Gly Arg Glu Asp Ile Ala Asp Arg Leu Ile Ser Ala Ser 
            580                 585                 590         


Leu Phe Leu Arg Phe Leu Cys Pro Ala Ile Met Ser Pro Ser Leu Phe 
        595                 600                 605             


Gly Leu Met Gln Glu Tyr Pro Asp Glu Gln Thr Ser Arg Thr Leu Thr 
    610                 615                 620                 


Leu Ile Ala Lys Val Ile Gln Asn Leu Ala Asn Phe Ser Lys Phe Thr 
625                 630                 635                 640 


Ser Lys Glu Asp Phe Leu Gly Phe Met Asn Glu Phe Leu Glu Leu Glu 
                645                 650                 655     


Trp Gly Ser Met Gln Gln Phe Leu Tyr Glu Ile Ser Asn Leu Asp Thr 
            660                 665                 670         


Leu Thr Asn Ser Ser Ser Phe Glu Gly Tyr Ile Asp Leu Gly Arg Glu 
        675                 680                 685             


Leu Ser Thr Leu His Ala Leu Leu Trp Glu Val Leu Pro Gln Leu Ser 
    690                 695                 700                 


Lys Glu Ala Leu Leu Lys Leu Gly Pro Leu Pro Arg Leu Leu Asn Asp 
705                 710                 715                 720 


Ile Ser Thr Ala Leu Arg Asn Pro Asn Ile Gln Arg Gln Pro Ser Arg 
                725                 730                 735     


Gln Ser Glu Arg Pro Arg Pro Gln Pro Val Val Leu Arg Gly Pro Ser 
            740                 745                 750         


Ala Glu Met Gln Gly Tyr Met Met Arg Asp Leu Asn Ser Ser Ile Asp 
        755                 760                 765             


Leu Gln Ser Phe Met Ala Arg Gly Leu Asn Ser Ser Met Asp Met Ala 
    770                 775                 780                 


Arg Leu Pro Ser Pro Thr Lys Glu Lys Pro Pro Pro Pro Pro Pro Gly 
785                 790                 795                 800 


Gly Gly Lys Asp Leu Phe Tyr Val Ser Arg Pro Pro Leu Ala Arg Ser 
                805                 810                 815     


Ser Pro Ala Tyr Cys Thr Ser Ser Ser Asp Ile Thr Glu Pro Glu Gln 
            820                 825                 830         


Lys Met Leu Ser Val Asn Lys Ser Val Ser Met Leu Asp Leu Gln Gly 
        835                 840                 845             


Asp Gly Pro Gly Gly Arg Leu Asn Ser Ser Ser Val Ser Asn Leu Ala 
    850                 855                 860                 


Ala Val Gly Asp Leu Leu His Ser Ser Gln Ala Ser Leu Thr Ala Ala 
865                 870                 875                 880 


Leu Gly Leu Arg Pro Ala Pro Ala Gly Arg Leu Ser Gln Gly Ser Gly 
                885                 890                 895     


Ser Ser Ile Thr Ala Ala Gly Met Arg Leu Ser Gln Met Gly Val Thr 
            900                 905                 910         


Thr Asp Gly Val Pro Ala Gln Gln Leu Arg Ile Pro Leu Ser Phe Gln 
        915                 920                 925             


Asn Pro Leu Phe His Met Ala Ala Asp Gly Pro Gly Pro Pro Gly Gly 
    930                 935                 940                 


His Gly Gly Gly Gly Gly His Gly Pro Pro Ser Ser His His His His 
945                 950                 955                 960 


His His His His His His Arg Gly Gly Glu Pro Pro Gly Asp Thr Phe 
                965                 970                 975     


Ala Pro Phe His Gly Tyr Ser Lys Ser Glu Asp Leu Ser Ser Gly Val 
            980                 985                 990         


Pro Lys Pro Pro Ala Ala Ser Ile  Leu His Ser His Ser  Tyr Ser Asp 
        995                 1000                 1005             


Glu Phe  Gly Pro Ser Gly Thr  Asp Phe Thr Arg Arg  Gln Leu Ser 
    1010                 1015                 1020             


Leu Gln  Asp Asn Leu Gln His  Met Leu Ser Pro Pro  Gln Ile Thr 
    1025                 1030                 1035             


Ile Gly  Pro Gln Arg Pro Ala  Pro Ser Gly Pro Gly  Gly Gly Ser 
    1040                 1045                 1050             


Gly Gly  Gly Ser Gly Gly Gly  Gly Gly Gly Gln Pro  Pro Pro Leu 
    1055                 1060                 1065             


Gln Arg  Gly Lys Ser Gln Gln  Leu Thr Val Ser Ala  Ala Gln Lys 
    1070                 1075                 1080             


Pro Arg  Pro Ser Ser Gly Asn  Leu Leu Gln Ser Pro  Glu Pro Ser 
    1085                 1090                 1095             


Tyr Gly  Pro Ala Arg Pro Arg  Gln Gln Ser Leu Ser  Lys Glu Gly 
    1100                 1105                 1110             


Ser Ile  Gly Gly Ser Gly Gly  Ser Gly Gly Gly Gly  Gly Gly Gly 
    1115                 1120                 1125             


Leu Lys  Pro Ser Ile Thr Lys  Gln His Ser Gln Thr  Pro Ser Thr 
    1130                 1135                 1140             


Leu Asn  Pro Thr Met Pro Ala  Ser Glu Arg Thr Val  Ala Trp Val 
    1145                 1150                 1155             


Ser Asn  Met Pro His Leu Ser  Ala Asp Ile Glu Ser  Ala His Ile 
    1160                 1165                 1170             


Glu Arg  Glu Glu Tyr Lys Leu  Lys Glu Tyr Ser Lys  Ser Met Asp 
    1175                 1180                 1185             


Glu Ser  Arg Leu Asp Arg Val  Lys Glu Tyr Glu Glu  Glu Ile His 
    1190                 1195                 1200             


Ser Leu  Lys Glu Arg Leu His  Met Ser Asn Arg Lys  Leu Glu Glu 
    1205                 1210                 1215             


Tyr Glu  Arg Arg Leu Leu Ser  Gln Glu Glu Gln Thr  Ser Lys Ile 
    1220                 1225                 1230             


Leu Met  Gln Tyr Gln Ala Arg  Leu Glu Gln Ser Glu  Lys Arg Leu 
    1235                 1240                 1245             


Arg Gln  Gln Gln Ala Glu Lys  Asp Ser Gln Ile Lys  Ser Ile Ile 
    1250                 1255                 1260             


Gly Arg  Leu Met Leu Val Glu  Glu Glu Leu Arg Arg  Asp His Pro 
    1265                 1270                 1275             


Ala Met  Ala Glu Pro Leu Pro  Glu Pro Lys Lys Arg  Leu Leu Asp 
    1280                 1285                 1290             


Ala Gln  Glu Arg Gln Leu Pro  Pro Leu Gly Pro Thr  Asn Pro Arg 
    1295                 1300                 1305             


Val Thr  Leu Ala Pro Pro Trp  Asn Gly Leu Ala Pro  Pro Ala Pro 
    1310                 1315                 1320             


Pro Pro  Pro Pro Arg Leu Gln  Ile Thr Glu Asn Gly  Glu Phe Arg 
    1325                 1330                 1335             


Asn Thr  Ala Asp His 
    1340             


<210>  3
<211>  5962
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (196)..(4074)

<400>  3
tctcggctgc cgctgctgcc gttggctctt attctcctcc tcctcctcct ctctcctcct     60

ctctgcttct ctctgctcct ctctcctcct ctctcctcct cctcctcctc cacctcctcc    120

tccttctccc cctctttctc cccctctttc tctcttcttt ctcccccgtc cccccgcccc    180

ctccccccag gcctg atg agc agg tct cga gcc tcc atc cat cgg ggg agc     231
                 Met Ser Arg Ser Arg Ala Ser Ile His Arg Gly Ser        
                 1               5                   10                 

atc ccc gcg atg tcc tat gcc ccc ttc aga gat gta cgg gga ccc tct      279
Ile Pro Ala Met Ser Tyr Ala Pro Phe Arg Asp Val Arg Gly Pro Ser         
        15                  20                  25                      

atg cac cga acc caa tac gtt cat tcc ccg tat gat cgt cct ggt tgg      327
Met His Arg Thr Gln Tyr Val His Ser Pro Tyr Asp Arg Pro Gly Trp         
    30                  35                  40                          

aac cct cgg ttc tgc atc atc tcg ggg aac cag ctg ctc atg ctg gat      375
Asn Pro Arg Phe Cys Ile Ile Ser Gly Asn Gln Leu Leu Met Leu Asp         
45                  50                  55                  60          

gag gat gag ata cac ccc cta ctg atc cgg gac cgg agg agc gag tcc      423
Glu Asp Glu Ile His Pro Leu Leu Ile Arg Asp Arg Arg Ser Glu Ser         
                65                  70                  75              

agt cgc aac aaa ctg ctg aga cgc aca gtc tcc gtg ccg gtg gag ggg      471
Ser Arg Asn Lys Leu Leu Arg Arg Thr Val Ser Val Pro Val Glu Gly         
            80                  85                  90                  

cgg ccc cac ggc gag cat gaa tac cac ttg ggt cgc tcg agg agg aag      519
Arg Pro His Gly Glu His Glu Tyr His Leu Gly Arg Ser Arg Arg Lys         
        95                  100                 105                     

agt gtc cca ggg ggg aag cag tac agc atg gag ggt gcc cct gct gcg      567
Ser Val Pro Gly Gly Lys Gln Tyr Ser Met Glu Gly Ala Pro Ala Ala         
    110                 115                 120                         

ccc ttc cgg ccc tcg caa ggc ttc ctg agc cga cgg cta aaa agc tcc      615
Pro Phe Arg Pro Ser Gln Gly Phe Leu Ser Arg Arg Leu Lys Ser Ser         
125                 130                 135                 140         

atc aaa cga acg aag tca caa ccc aaa ctt gac cgg acc agc agc ttt      663
Ile Lys Arg Thr Lys Ser Gln Pro Lys Leu Asp Arg Thr Ser Ser Phe         
                145                 150                 155             

cgc cag atc ctg cct cgc ttc cga agt gct gac cat gac cgg gcc cgg      711
Arg Gln Ile Leu Pro Arg Phe Arg Ser Ala Asp His Asp Arg Ala Arg         
            160                 165                 170                 

ctg atg caa agc ttt aag gag tca cac tct cat gag tcc ttg ctg agt      759
Leu Met Gln Ser Phe Lys Glu Ser His Ser His Glu Ser Leu Leu Ser         
        175                 180                 185                     

cct agc agt gca gct gag gca ttg gag ctc aac ttg gat gaa gat tcc      807
Pro Ser Ser Ala Ala Glu Ala Leu Glu Leu Asn Leu Asp Glu Asp Ser         
    190                 195                 200                         

att atc aag cca gtg cac agc tcc atc ctg ggc cag gag ttc tgt ttt      855
Ile Ile Lys Pro Val His Ser Ser Ile Leu Gly Gln Glu Phe Cys Phe         
205                 210                 215                 220         

gag gta aca act tca tca gga aca aaa tgc ttt gcc tgt cgg tct gcg      903
Glu Val Thr Thr Ser Ser Gly Thr Lys Cys Phe Ala Cys Arg Ser Ala         
                225                 230                 235             

gcc gaa aga gac aaa tgg att gag aat ctg cag cgg gca gta aag ccc      951
Ala Glu Arg Asp Lys Trp Ile Glu Asn Leu Gln Arg Ala Val Lys Pro         
            240                 245                 250                 

aac aag gac aac agc cgc cgg gta gac aat gtg cta aag ctg tgg atc      999
Asn Lys Asp Asn Ser Arg Arg Val Asp Asn Val Leu Lys Leu Trp Ile         
        255                 260                 265                     

ata gag gcc cgg gag ctg ccc ccc aag aag cgg tac tac tgt gag ctc     1047
Ile Glu Ala Arg Glu Leu Pro Pro Lys Lys Arg Tyr Tyr Cys Glu Leu         
    270                 275                 280                         

tgc ctg gat gac atg ctg tat gca cgc acc acc tcc aag ccc cgc tct     1095
Cys Leu Asp Asp Met Leu Tyr Ala Arg Thr Thr Ser Lys Pro Arg Ser         
285                 290                 295                 300         

gcc tct ggg gac acc gtc ttc tgg ggc gag cac ttc gag ttt aac aac     1143
Ala Ser Gly Asp Thr Val Phe Trp Gly Glu His Phe Glu Phe Asn Asn         
                305                 310                 315             

ctg ccg gct gtc cgt gcc ctg cgg ctg cat ctg tac cgt gac tca gac     1191
Leu Pro Ala Val Arg Ala Leu Arg Leu His Leu Tyr Arg Asp Ser Asp         
            320                 325                 330                 

aaa aag cgc aag aag gac aag gca ggc tat gtc ggc ctg gtg act gtg     1239
Lys Lys Arg Lys Lys Asp Lys Ala Gly Tyr Val Gly Leu Val Thr Val         
        335                 340                 345                     

cca gtg gcc acc ctg gct ggg cgc cac ttc aca gag cag tgg tac cct     1287
Pro Val Ala Thr Leu Ala Gly Arg His Phe Thr Glu Gln Trp Tyr Pro         
    350                 355                 360                         

gta acc ctg cca aca ggc agt ggg gga tct ggg ggc atg ggt tcg gga     1335
Val Thr Leu Pro Thr Gly Ser Gly Gly Ser Gly Gly Met Gly Ser Gly         
365                 370                 375                 380         

ggg gga ggg ggc tcg ggg ggt ggc tca ggg ggc aag ggc aaa gga ggt     1383
Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Lys Gly Lys Gly Gly         
                385                 390                 395             

tgc ccg gct gtg cgg ctg aaa gca cgt tac cag aca atg agc atc ttg     1431
Cys Pro Ala Val Arg Leu Lys Ala Arg Tyr Gln Thr Met Ser Ile Leu         
            400                 405                 410                 

ccc atg gag cta tat aaa gag ttt gca gag tat gtc acc aac cat tat     1479
Pro Met Glu Leu Tyr Lys Glu Phe Ala Glu Tyr Val Thr Asn His Tyr         
        415                 420                 425                     

cgg atg ctg tgt gca gtc ttg gag ccc gcc ctg aat gtc aaa ggc aag     1527
Arg Met Leu Cys Ala Val Leu Glu Pro Ala Leu Asn Val Lys Gly Lys         
    430                 435                 440                         

gag gag gtt gcc agt gca cta gtt cac atc ctg cag agt aca ggc aag     1575
Glu Glu Val Ala Ser Ala Leu Val His Ile Leu Gln Ser Thr Gly Lys         
445                 450                 455                 460         

gcc aag gac ttc ctt tca gac atg gcc atg tct gag gta gac cgg ttc     1623
Ala Lys Asp Phe Leu Ser Asp Met Ala Met Ser Glu Val Asp Arg Phe         
                465                 470                 475             

atg gaa cgg gag cac ctc ata ttc cgc gag aac acg ctt gcc act aaa     1671
Met Glu Arg Glu His Leu Ile Phe Arg Glu Asn Thr Leu Ala Thr Lys         
            480                 485                 490                 

gcc ata gaa gag tat atg aga ctg att ggt cag aaa tac ctc aag gat     1719
Ala Ile Glu Glu Tyr Met Arg Leu Ile Gly Gln Lys Tyr Leu Lys Asp         
        495                 500                 505                     

gcc att gga gaa ttc atc cgt gct ctg tat gaa tct gag gaa aac tgc     1767
Ala Ile Gly Glu Phe Ile Arg Ala Leu Tyr Glu Ser Glu Glu Asn Cys         
    510                 515                 520                         

gag gta gac cct atc aag tgc aca gca tcc agt ttg gca gag cac cag     1815
Glu Val Asp Pro Ile Lys Cys Thr Ala Ser Ser Leu Ala Glu His Gln         
525                 530                 535                 540         

gcc aac ctg cga atg tgc tgt gag ttg gcc ctg tgc aag gtg gtc aac     1863
Ala Asn Leu Arg Met Cys Cys Glu Leu Ala Leu Cys Lys Val Val Asn         
                545                 550                 555             

tcc cac tgc gtg ttc ccg agg gag ctg aag gag gtg ttt gct tcg tgg     1911
Ser His Cys Val Phe Pro Arg Glu Leu Lys Glu Val Phe Ala Ser Trp         
            560                 565                 570                 

cgg ctg cgc tgc gca gag cga ggc cgg gag gac atc gca gac agg ctt     1959
Arg Leu Arg Cys Ala Glu Arg Gly Arg Glu Asp Ile Ala Asp Arg Leu         
        575                 580                 585                     

atc agc gcc tca ctc ttc ctg cgc ttc ctc tgc cca gcg att atg tcg     2007
Ile Ser Ala Ser Leu Phe Leu Arg Phe Leu Cys Pro Ala Ile Met Ser         
    590                 595                 600                         

ccc agt ctc ttt ggg ctt atg cag gag tac cca gat gag cag acc tca     2055
Pro Ser Leu Phe Gly Leu Met Gln Glu Tyr Pro Asp Glu Gln Thr Ser         
605                 610                 615                 620         

cga acc ctc acc ctc att gcc aag gtc atc cag aac ctg gcc aac ttt     2103
Arg Thr Leu Thr Leu Ile Ala Lys Val Ile Gln Asn Leu Ala Asn Phe         
                625                 630                 635             

tcc aag ttt acc tca aag gag gac ttt ctg ggc ttc atg aat gag ttt     2151
Ser Lys Phe Thr Ser Lys Glu Asp Phe Leu Gly Phe Met Asn Glu Phe         
            640                 645                 650                 

ctg gag ctg gaa tgg ggt tcc atg cag cag ttt ttg tat gag atc tcc     2199
Leu Glu Leu Glu Trp Gly Ser Met Gln Gln Phe Leu Tyr Glu Ile Ser         
        655                 660                 665                     

aat ctg gac acg cta acc aac agc agt agc ttt gag ggt tac atc gac     2247
Asn Leu Asp Thr Leu Thr Asn Ser Ser Ser Phe Glu Gly Tyr Ile Asp         
    670                 675                 680                         

ttg ggc cga gag ctc tcc aca ctg cat gcc cta ctc tgg gag gtg ctg     2295
Leu Gly Arg Glu Leu Ser Thr Leu His Ala Leu Leu Trp Glu Val Leu         
685                 690                 695                 700         

ccc cag ctc agc aag gaa gcc ctc ctg aag ctg ggt cca ctg ccc cgg     2343
Pro Gln Leu Ser Lys Glu Ala Leu Leu Lys Leu Gly Pro Leu Pro Arg         
                705                 710                 715             

ctc ctc aac gac atc agc aca gct ctg agg aac ccc aac atc caa agg     2391
Leu Leu Asn Asp Ile Ser Thr Ala Leu Arg Asn Pro Asn Ile Gln Arg         
            720                 725                 730                 

cag cca agc cgc cag agt gag cgg ccc cgg cct cag cct gtg gta ctg     2439
Gln Pro Ser Arg Gln Ser Glu Arg Pro Arg Pro Gln Pro Val Val Leu         
        735                 740                 745                     

cgg ggg cca tcg gct gag atg cag ggc tac atg atg cgg gac ctc aac     2487
Arg Gly Pro Ser Ala Glu Met Gln Gly Tyr Met Met Arg Asp Leu Asn         
    750                 755                 760                         

agc tct atg gac atg gct cgc ctc ccc tcc cca acc aag gaa aag cca     2535
Ser Ser Met Asp Met Ala Arg Leu Pro Ser Pro Thr Lys Glu Lys Pro         
765                 770                 775                 780         

ccc cca cca ccg cct ggt ggt ggt aaa gac ctg ttc tat gta agc cgt     2583
Pro Pro Pro Pro Pro Gly Gly Gly Lys Asp Leu Phe Tyr Val Ser Arg         
                785                 790                 795             

cca ccc ctg gcc cgt tcc tca cca gca tac tgc acg agc agc tcg gac     2631
Pro Pro Leu Ala Arg Ser Ser Pro Ala Tyr Cys Thr Ser Ser Ser Asp         
            800                 805                 810                 

atc aca gag cca gag cag aag atg ctg agt gtc aac aag agt gtg tcc     2679
Ile Thr Glu Pro Glu Gln Lys Met Leu Ser Val Asn Lys Ser Val Ser         
        815                 820                 825                     

atg ctg gac tta cag ggt gat ggg cct ggt ggc cgc ctc aac agc agc     2727
Met Leu Asp Leu Gln Gly Asp Gly Pro Gly Gly Arg Leu Asn Ser Ser         
    830                 835                 840                         

agt gtt tcg aac ctg gcg gcc gta ggg gac ctg ctg cac tca agc cag     2775
Ser Val Ser Asn Leu Ala Ala Val Gly Asp Leu Leu His Ser Ser Gln         
845                 850                 855                 860         

gcc tcg ctg aca gca gcc ttg ggg cta cgg cct gcg cct gcc gga cgc     2823
Ala Ser Leu Thr Ala Ala Leu Gly Leu Arg Pro Ala Pro Ala Gly Arg         
                865                 870                 875             

ctc tcc cag ggg agt ggc tca tcc atc acg gcg gct ggc atg cgc ctc     2871
Leu Ser Gln Gly Ser Gly Ser Ser Ile Thr Ala Ala Gly Met Arg Leu         
            880                 885                 890                 

agc cag atg ggt gtc acc aca gac ggt gtc cct gcc cag caa ctg cga     2919
Ser Gln Met Gly Val Thr Thr Asp Gly Val Pro Ala Gln Gln Leu Arg         
        895                 900                 905                     

atc ccc ctc tcc ttc cag aac cct ctc ttc cac atg gct gct gat ggg     2967
Ile Pro Leu Ser Phe Gln Asn Pro Leu Phe His Met Ala Ala Asp Gly         
    910                 915                 920                         

cca ggt ccc cca ggc ggc cat gga ggg ggc ggt ggc cat ggc cca cct     3015
Pro Gly Pro Pro Gly Gly His Gly Gly Gly Gly Gly His Gly Pro Pro         
925                 930                 935                 940         

tcc tcc cat cac cac cac cac cac cat cac cac cac cga ggt gga gag     3063
Ser Ser His His His His His His His His His His Arg Gly Gly Glu         
                945                 950                 955             

ccc cct ggg gac acc ttt gcc cca ttc cat ggc tat agc aag agt gag     3111
Pro Pro Gly Asp Thr Phe Ala Pro Phe His Gly Tyr Ser Lys Ser Glu         
            960                 965                 970                 

gac ctc tct tcc ggg gtc ccc aag ccc cct gct gcc tcc atc ctt cat     3159
Asp Leu Ser Ser Gly Val Pro Lys Pro Pro Ala Ala Ser Ile Leu His         
        975                 980                 985                     

agc cac agc tac agt gat gag ttt gga ccc tct ggc  act gac ttc acc    3207
Ser His Ser Tyr Ser Asp Glu Phe Gly Pro Ser Gly  Thr Asp Phe Thr        
    990                 995                 1000                        

cgt  cgg cag ctt tca ctc  cag gac aac ctg cag  cac atg ctg tcc      3252
Arg  Arg Gln Leu Ser Leu  Gln Asp Asn Leu Gln  His Met Leu Ser          
1005                 1010                 1015                          

cct  ccc cag atc acc att  ggt ccc cag agg cca  gcc ccc tca ggg      3297
Pro  Pro Gln Ile Thr Ile  Gly Pro Gln Arg Pro  Ala Pro Ser Gly          
1020                 1025                 1030                          

cct  gga ggt ggg agc ggt  ggg ggc agc ggt ggg  ggt ggc ggg ggc      3342
Pro  Gly Gly Gly Ser Gly  Gly Gly Ser Gly Gly  Gly Gly Gly Gly          
1035                 1040                 1045                          

cag  ccg cct cca ttg cag  agg ggc aag tct cag  cag ttg aca gtc      3387
Gln  Pro Pro Pro Leu Gln  Arg Gly Lys Ser Gln  Gln Leu Thr Val          
1050                 1055                 1060                          

agc  gca gcc cag aaa ccc  cgg cca tcc agc ggg  aat cta ttg cag      3432
Ser  Ala Ala Gln Lys Pro  Arg Pro Ser Ser Gly  Asn Leu Leu Gln          
1065                 1070                 1075                          

tcc  cca gag cca agt tat  ggc ccc gcc cgt cca  cgg caa cag agc      3477
Ser  Pro Glu Pro Ser Tyr  Gly Pro Ala Arg Pro  Arg Gln Gln Ser          
1080                 1085                 1090                          

ctc  agc aag gag ggc agc  att ggg ggc agc ggg  ggc agc ggt ggc      3522
Leu  Ser Lys Glu Gly Ser  Ile Gly Gly Ser Gly  Gly Ser Gly Gly          
1095                 1100                 1105                          

gga  ggg ggt ggg ggg ctg  aag ccc tcc atc acc  aag cag cat tct      3567
Gly  Gly Gly Gly Gly Leu  Lys Pro Ser Ile Thr  Lys Gln His Ser          
1110                 1115                 1120                          

cag  aca cca tcc aca ttg  aac ccc aca atg cca  gcc tct gag cgg      3612
Gln  Thr Pro Ser Thr Leu  Asn Pro Thr Met Pro  Ala Ser Glu Arg          
1125                 1130                 1135                          

aca  gtg gcc tgg gtc tcc  aac atg cct cac ctg  tcg gct gac atc      3657
Thr  Val Ala Trp Val Ser  Asn Met Pro His Leu  Ser Ala Asp Ile          
1140                 1145                 1150                          

gag  agt gcc cac atc gag  cgg gaa gag tac aag  ctc aag gag tac      3702
Glu  Ser Ala His Ile Glu  Arg Glu Glu Tyr Lys  Leu Lys Glu Tyr          
1155                 1160                 1165                          

tca  aaa tcg atg gat gag  agc cgg ctg gat agg  gag tac gag gag      3747
Ser  Lys Ser Met Asp Glu  Ser Arg Leu Asp Arg  Glu Tyr Glu Glu          
1170                 1175                 1180                          

gag  att cac tca ctg aaa  gag cgg ctg cac atg  tcc aac cgg aag      3792
Glu  Ile His Ser Leu Lys  Glu Arg Leu His Met  Ser Asn Arg Lys          
1185                 1190                 1195                          

ctg  gaa gag tat gag cgg  agg ctg ctg tcc cag  gaa gaa caa acc      3837
Leu  Glu Glu Tyr Glu Arg  Arg Leu Leu Ser Gln  Glu Glu Gln Thr          
1200                 1205                 1210                          

agc  aaa atc ctg atg cag  tat cag gcc cga ctg  gag cag agt gag      3882
Ser  Lys Ile Leu Met Gln  Tyr Gln Ala Arg Leu  Glu Gln Ser Glu          
1215                 1220                 1225                          

aag  agg cta agg cag cag  cag gca gag aag gat  tcc cag atc aag      3927
Lys  Arg Leu Arg Gln Gln  Gln Ala Glu Lys Asp  Ser Gln Ile Lys          
1230                 1235                 1240                          

agc  atc att ggc agg ctg  atg ctg gtg gag gag  gag ctg cgc cgg      3972
Ser  Ile Ile Gly Arg Leu  Met Leu Val Glu Glu  Glu Leu Arg Arg          
1245                 1250                 1255                          

gac  cac ccc gcc atg gct  gag ccg ctg cca gaa  ccc aag aag agg      4017
Asp  His Pro Ala Met Ala  Glu Pro Leu Pro Glu  Pro Lys Lys Arg          
1260                 1265                 1270                          

ctg  ctc gac gct cag aga  ggc agc ttc ccc cct  tgg gtc caa caa      4062
Leu  Leu Asp Ala Gln Arg  Gly Ser Phe Pro Pro  Trp Val Gln Gln          
1275                 1280                 1285                          

acc  cgc gtg tga cgctggcccc accgtggaat ggcctggccc ccccagcccc        4114
Thr  Arg Val                                                            
1290                                                                    

accaccccca ccccggctgc agattacgga gaacggcgag ttccgaaaca ccgcagacca   4174

ctagcccacc cagcatcaga gaccttctct tcctttcctg tgcaccccac cctgtaacag   4234

caccaaccac caggattgga catcaccgag gaacagcggg attgcctccc cgaatgcctc   4294

cctgggaggc acactgattg cccaccccca ccactgcacc atttccagga gggagagtgg   4354

ggaccctcag ccgccccctt ttccttccca ttggggtgct gccctctctt tgacccccag   4414

ggacccttgc cccaggacac cgcctacccc gtacagaccc cttcactccg gggtgctatc   4474

cccatcctct gcctcatcgt tcccctgagc actgggggac agaccctcac ccccaccctg   4534

ggggtgtggc acctccaaac tttcaacttc agggtgattt ttttagcagt aaccagagct   4594

gacaatctaa ctcccctcca ccgccccatt ttggcctccc ctgcccccct tgttatgggg   4654

aggggacccc gggtgagggg gccctattac cccttgattt ctcaggagcg tctggggggg   4714

ctcagcacgc acaaactcct tctccttcta ccactcttaa atttactccc tccccaccca   4774

gaacccagat ggggtggagg gggccaccgg ggcagggagg gggcggcaag gggggaatgg   4834

gagttgtctc cccttctccc cacacctgat ctgctctcgg ctggtcccag agcggggtga   4894

gggggcttat gcccccccct cccccagtgt gttgggtggg gtggaattga ggttagggtg   4954

aggggtcagg gtttaggagg gtgtgtatgt tgggaggaca ggctagttga tctgtcctac   5014

tctgacacac agtcccctct gccccttcct tctctcttct tggtctctac tcccaggggg   5074

aggggggaac ttactctagg aaaagccatg tctctctccc ccagggtggg gggacctgtg   5134

ttggaggagg ggtgttgggg ggcccccttc catgactctg tcccctgggg gaggtaggac   5194

agggctgggc ttccctctca tcctccccct cccaatctcc ttccacctcc ctccctcccg   5254

ccagctccac gatttttcgg tgtttctctg tacatagttt tctggcggga taggggaggt   5314

aggatggatg gggtttgggg tgggtaggcc atgggagggg agaagcccct ccttggcacc   5374

ccctcttccc tgactgctgt cccctaccca gccttgcccc cttcatcctt ttgcgtttgg   5434

tattgagact ctcctagact ctactcctct ttcttttgta tggacagttc cccttcagtc   5494

ccatccccct acacatacac ccagccgggg ccaaatttat acttatataa aagttgtaaa   5554

tatgtgaaat tttatccctg tgccctttcc ccacctcagg ccctacccct ggaccctccc   5614

caaccttcct tctctcttct ttggctgttg taattatctg gggtttgtac tgtacatatc   5674

cggggtgtgt gtgtgtgggc tgggggcaac ccttctgtac agagcttcct ggccccctcc   5734

ccccccgccc ctctgcttcc ctccccaccc accacctcaa gggtagggag ttgctcttcc   5794

tacctgtttt attttgtttt ctcgttctcc ctccccaccc cactcccagc cttatctatc   5854

ccccctcact gtcccctttt ctccactccc agccccattt cctttttttc tggagtgtgt   5914

ggtgaaacag aaaaaaacat gtttaataaa cggagattgt tcttttaa                5962


<210>  4
<211>  1292
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Arg Ser Arg Ala Ser Ile His Arg Gly Ser Ile Pro Ala Met 
1               5                   10                  15      


Ser Tyr Ala Pro Phe Arg Asp Val Arg Gly Pro Ser Met His Arg Thr 
            20                  25                  30          


Gln Tyr Val His Ser Pro Tyr Asp Arg Pro Gly Trp Asn Pro Arg Phe 
        35                  40                  45              


Cys Ile Ile Ser Gly Asn Gln Leu Leu Met Leu Asp Glu Asp Glu Ile 
    50                  55                  60                  


His Pro Leu Leu Ile Arg Asp Arg Arg Ser Glu Ser Ser Arg Asn Lys 
65                  70                  75                  80  


Leu Leu Arg Arg Thr Val Ser Val Pro Val Glu Gly Arg Pro His Gly 
                85                  90                  95      


Glu His Glu Tyr His Leu Gly Arg Ser Arg Arg Lys Ser Val Pro Gly 
            100                 105                 110         


Gly Lys Gln Tyr Ser Met Glu Gly Ala Pro Ala Ala Pro Phe Arg Pro 
        115                 120                 125             


Ser Gln Gly Phe Leu Ser Arg Arg Leu Lys Ser Ser Ile Lys Arg Thr 
    130                 135                 140                 


Lys Ser Gln Pro Lys Leu Asp Arg Thr Ser Ser Phe Arg Gln Ile Leu 
145                 150                 155                 160 


Pro Arg Phe Arg Ser Ala Asp His Asp Arg Ala Arg Leu Met Gln Ser 
                165                 170                 175     


Phe Lys Glu Ser His Ser His Glu Ser Leu Leu Ser Pro Ser Ser Ala 
            180                 185                 190         


Ala Glu Ala Leu Glu Leu Asn Leu Asp Glu Asp Ser Ile Ile Lys Pro 
        195                 200                 205             


Val His Ser Ser Ile Leu Gly Gln Glu Phe Cys Phe Glu Val Thr Thr 
    210                 215                 220                 


Ser Ser Gly Thr Lys Cys Phe Ala Cys Arg Ser Ala Ala Glu Arg Asp 
225                 230                 235                 240 


Lys Trp Ile Glu Asn Leu Gln Arg Ala Val Lys Pro Asn Lys Asp Asn 
                245                 250                 255     


Ser Arg Arg Val Asp Asn Val Leu Lys Leu Trp Ile Ile Glu Ala Arg 
            260                 265                 270         


Glu Leu Pro Pro Lys Lys Arg Tyr Tyr Cys Glu Leu Cys Leu Asp Asp 
        275                 280                 285             


Met Leu Tyr Ala Arg Thr Thr Ser Lys Pro Arg Ser Ala Ser Gly Asp 
    290                 295                 300                 


Thr Val Phe Trp Gly Glu His Phe Glu Phe Asn Asn Leu Pro Ala Val 
305                 310                 315                 320 


Arg Ala Leu Arg Leu His Leu Tyr Arg Asp Ser Asp Lys Lys Arg Lys 
                325                 330                 335     


Lys Asp Lys Ala Gly Tyr Val Gly Leu Val Thr Val Pro Val Ala Thr 
            340                 345                 350         


Leu Ala Gly Arg His Phe Thr Glu Gln Trp Tyr Pro Val Thr Leu Pro 
        355                 360                 365             


Thr Gly Ser Gly Gly Ser Gly Gly Met Gly Ser Gly Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Ser Gly Gly Lys Gly Lys Gly Gly Cys Pro Ala Val 
385                 390                 395                 400 


Arg Leu Lys Ala Arg Tyr Gln Thr Met Ser Ile Leu Pro Met Glu Leu 
                405                 410                 415     


Tyr Lys Glu Phe Ala Glu Tyr Val Thr Asn His Tyr Arg Met Leu Cys 
            420                 425                 430         


Ala Val Leu Glu Pro Ala Leu Asn Val Lys Gly Lys Glu Glu Val Ala 
        435                 440                 445             


Ser Ala Leu Val His Ile Leu Gln Ser Thr Gly Lys Ala Lys Asp Phe 
    450                 455                 460                 


Leu Ser Asp Met Ala Met Ser Glu Val Asp Arg Phe Met Glu Arg Glu 
465                 470                 475                 480 


His Leu Ile Phe Arg Glu Asn Thr Leu Ala Thr Lys Ala Ile Glu Glu 
                485                 490                 495     


Tyr Met Arg Leu Ile Gly Gln Lys Tyr Leu Lys Asp Ala Ile Gly Glu 
            500                 505                 510         


Phe Ile Arg Ala Leu Tyr Glu Ser Glu Glu Asn Cys Glu Val Asp Pro 
        515                 520                 525             


Ile Lys Cys Thr Ala Ser Ser Leu Ala Glu His Gln Ala Asn Leu Arg 
    530                 535                 540                 


Met Cys Cys Glu Leu Ala Leu Cys Lys Val Val Asn Ser His Cys Val 
545                 550                 555                 560 


Phe Pro Arg Glu Leu Lys Glu Val Phe Ala Ser Trp Arg Leu Arg Cys 
                565                 570                 575     


Ala Glu Arg Gly Arg Glu Asp Ile Ala Asp Arg Leu Ile Ser Ala Ser 
            580                 585                 590         


Leu Phe Leu Arg Phe Leu Cys Pro Ala Ile Met Ser Pro Ser Leu Phe 
        595                 600                 605             


Gly Leu Met Gln Glu Tyr Pro Asp Glu Gln Thr Ser Arg Thr Leu Thr 
    610                 615                 620                 


Leu Ile Ala Lys Val Ile Gln Asn Leu Ala Asn Phe Ser Lys Phe Thr 
625                 630                 635                 640 


Ser Lys Glu Asp Phe Leu Gly Phe Met Asn Glu Phe Leu Glu Leu Glu 
                645                 650                 655     


Trp Gly Ser Met Gln Gln Phe Leu Tyr Glu Ile Ser Asn Leu Asp Thr 
            660                 665                 670         


Leu Thr Asn Ser Ser Ser Phe Glu Gly Tyr Ile Asp Leu Gly Arg Glu 
        675                 680                 685             


Leu Ser Thr Leu His Ala Leu Leu Trp Glu Val Leu Pro Gln Leu Ser 
    690                 695                 700                 


Lys Glu Ala Leu Leu Lys Leu Gly Pro Leu Pro Arg Leu Leu Asn Asp 
705                 710                 715                 720 


Ile Ser Thr Ala Leu Arg Asn Pro Asn Ile Gln Arg Gln Pro Ser Arg 
                725                 730                 735     


Gln Ser Glu Arg Pro Arg Pro Gln Pro Val Val Leu Arg Gly Pro Ser 
            740                 745                 750         


Ala Glu Met Gln Gly Tyr Met Met Arg Asp Leu Asn Ser Ser Met Asp 
        755                 760                 765             


Met Ala Arg Leu Pro Ser Pro Thr Lys Glu Lys Pro Pro Pro Pro Pro 
    770                 775                 780                 


Pro Gly Gly Gly Lys Asp Leu Phe Tyr Val Ser Arg Pro Pro Leu Ala 
785                 790                 795                 800 


Arg Ser Ser Pro Ala Tyr Cys Thr Ser Ser Ser Asp Ile Thr Glu Pro 
                805                 810                 815     


Glu Gln Lys Met Leu Ser Val Asn Lys Ser Val Ser Met Leu Asp Leu 
            820                 825                 830         


Gln Gly Asp Gly Pro Gly Gly Arg Leu Asn Ser Ser Ser Val Ser Asn 
        835                 840                 845             


Leu Ala Ala Val Gly Asp Leu Leu His Ser Ser Gln Ala Ser Leu Thr 
    850                 855                 860                 


Ala Ala Leu Gly Leu Arg Pro Ala Pro Ala Gly Arg Leu Ser Gln Gly 
865                 870                 875                 880 


Ser Gly Ser Ser Ile Thr Ala Ala Gly Met Arg Leu Ser Gln Met Gly 
                885                 890                 895     


Val Thr Thr Asp Gly Val Pro Ala Gln Gln Leu Arg Ile Pro Leu Ser 
            900                 905                 910         


Phe Gln Asn Pro Leu Phe His Met Ala Ala Asp Gly Pro Gly Pro Pro 
        915                 920                 925             


Gly Gly His Gly Gly Gly Gly Gly His Gly Pro Pro Ser Ser His His 
    930                 935                 940                 


His His His His His His His His Arg Gly Gly Glu Pro Pro Gly Asp 
945                 950                 955                 960 


Thr Phe Ala Pro Phe His Gly Tyr Ser Lys Ser Glu Asp Leu Ser Ser 
                965                 970                 975     


Gly Val Pro Lys Pro Pro Ala Ala Ser Ile Leu His Ser His Ser Tyr 
            980                 985                 990         


Ser Asp Glu Phe Gly Pro Ser Gly  Thr Asp Phe Thr Arg  Arg Gln Leu 
        995                 1000                 1005             


Ser Leu  Gln Asp Asn Leu Gln  His Met Leu Ser Pro  Pro Gln Ile 
    1010                 1015                 1020             


Thr Ile  Gly Pro Gln Arg Pro  Ala Pro Ser Gly Pro  Gly Gly Gly 
    1025                 1030                 1035             


Ser Gly  Gly Gly Ser Gly Gly  Gly Gly Gly Gly Gln  Pro Pro Pro 
    1040                 1045                 1050             


Leu Gln  Arg Gly Lys Ser Gln  Gln Leu Thr Val Ser  Ala Ala Gln 
    1055                 1060                 1065             


Lys Pro  Arg Pro Ser Ser Gly  Asn Leu Leu Gln Ser  Pro Glu Pro 
    1070                 1075                 1080             


Ser Tyr  Gly Pro Ala Arg Pro  Arg Gln Gln Ser Leu  Ser Lys Glu 
    1085                 1090                 1095             


Gly Ser  Ile Gly Gly Ser Gly  Gly Ser Gly Gly Gly  Gly Gly Gly 
    1100                 1105                 1110             


Gly Leu  Lys Pro Ser Ile Thr  Lys Gln His Ser Gln  Thr Pro Ser 
    1115                 1120                 1125             


Thr Leu  Asn Pro Thr Met Pro  Ala Ser Glu Arg Thr  Val Ala Trp 
    1130                 1135                 1140             


Val Ser  Asn Met Pro His Leu  Ser Ala Asp Ile Glu  Ser Ala His 
    1145                 1150                 1155             


Ile Glu  Arg Glu Glu Tyr Lys  Leu Lys Glu Tyr Ser  Lys Ser Met 
    1160                 1165                 1170             


Asp Glu  Ser Arg Leu Asp Arg  Glu Tyr Glu Glu Glu  Ile His Ser 
    1175                 1180                 1185             


Leu Lys  Glu Arg Leu His Met  Ser Asn Arg Lys Leu  Glu Glu Tyr 
    1190                 1195                 1200             


Glu Arg  Arg Leu Leu Ser Gln  Glu Glu Gln Thr Ser  Lys Ile Leu 
    1205                 1210                 1215             


Met Gln  Tyr Gln Ala Arg Leu  Glu Gln Ser Glu Lys  Arg Leu Arg 
    1220                 1225                 1230             


Gln Gln  Gln Ala Glu Lys Asp  Ser Gln Ile Lys Ser  Ile Ile Gly 
    1235                 1240                 1245             


Arg Leu  Met Leu Val Glu Glu  Glu Leu Arg Arg Asp  His Pro Ala 
    1250                 1255                 1260             


Met Ala  Glu Pro Leu Pro Glu  Pro Lys Lys Arg Leu  Leu Asp Ala 
    1265                 1270                 1275             


Gln Arg  Gly Ser Phe Pro Pro  Trp Val Gln Gln Thr  Arg Val 
    1280                 1285                 1290         


<210>  5
<211>  6043
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (196)..(4053)

<400>  5
tctcggctgc cgctgctgcc gttggctctt attctcctcc tcctcctcct ctctcctcct     60

ctctgcttct ctctgctcct ctctcctcct ctctcctcct cctcctcctc cacctcctcc    120

tccttctccc cctctttctc cccctctttc tctcttcttt ctcccccgtc cccccgcccc    180

ctccccccag gcctg atg agc agg tct cga gcc tcc atc cat cgg ggg agc     231
                 Met Ser Arg Ser Arg Ala Ser Ile His Arg Gly Ser        
                 1               5                   10                 

atc ccc gcg atg tcc tat gcc ccc ttc aga gat gta cgg gga ccc tct      279
Ile Pro Ala Met Ser Tyr Ala Pro Phe Arg Asp Val Arg Gly Pro Ser         
        15                  20                  25                      

atg cac cga acc caa tac gtt cat tcc ccg tat gat cgt cct ggt tgg      327
Met His Arg Thr Gln Tyr Val His Ser Pro Tyr Asp Arg Pro Gly Trp         
    30                  35                  40                          

aac cct cgg ttc tgc atc atc tcg ggg aac cag ctg ctc atg ctg gat      375
Asn Pro Arg Phe Cys Ile Ile Ser Gly Asn Gln Leu Leu Met Leu Asp         
45                  50                  55                  60          

gag gat gag ata cac ccc cta ctg atc cgg gac cgg agg agc gag tcc      423
Glu Asp Glu Ile His Pro Leu Leu Ile Arg Asp Arg Arg Ser Glu Ser         
                65                  70                  75              

agt cgc aac aaa ctg ctg aga cgc aca gtc tcc gtg ccg gtg gag ggg      471
Ser Arg Asn Lys Leu Leu Arg Arg Thr Val Ser Val Pro Val Glu Gly         
            80                  85                  90                  

cgg ccc cac ggc gag cat gaa tac cac ttg ggt cgc tcg agg agg aag      519
Arg Pro His Gly Glu His Glu Tyr His Leu Gly Arg Ser Arg Arg Lys         
        95                  100                 105                     

agt gtc cca ggg ggg aag cag tac agc atg gag ggt gcc cct gct gcg      567
Ser Val Pro Gly Gly Lys Gln Tyr Ser Met Glu Gly Ala Pro Ala Ala         
    110                 115                 120                         

ccc ttc cgg ccc tcg caa ggc ttc ctg agc cga cgg cta aaa agc tcc      615
Pro Phe Arg Pro Ser Gln Gly Phe Leu Ser Arg Arg Leu Lys Ser Ser         
125                 130                 135                 140         

atc aaa cga acg aag tca caa ccc aaa ctt gac cgg acc agc agc ttt      663
Ile Lys Arg Thr Lys Ser Gln Pro Lys Leu Asp Arg Thr Ser Ser Phe         
                145                 150                 155             

cgc cag atc ctg cct cgc ttc cga agt gct gac cat gac cgg gcc cgg      711
Arg Gln Ile Leu Pro Arg Phe Arg Ser Ala Asp His Asp Arg Ala Arg         
            160                 165                 170                 

ctg atg caa agc ttt aag gag tca cac tct cat gag tcc ttg ctg agt      759
Leu Met Gln Ser Phe Lys Glu Ser His Ser His Glu Ser Leu Leu Ser         
        175                 180                 185                     

cct agc agt gca gct gag gca ttg gag ctc aac ttg gat gaa gat tcc      807
Pro Ser Ser Ala Ala Glu Ala Leu Glu Leu Asn Leu Asp Glu Asp Ser         
    190                 195                 200                         

att atc aag cca gtg cac agc tcc atc ctg ggc cag gag ttc tgt ttt      855
Ile Ile Lys Pro Val His Ser Ser Ile Leu Gly Gln Glu Phe Cys Phe         
205                 210                 215                 220         

gag gta aca act tca tca gga aca aaa tgc ttt gcc tgt cgg tct gcg      903
Glu Val Thr Thr Ser Ser Gly Thr Lys Cys Phe Ala Cys Arg Ser Ala         
                225                 230                 235             

gcc gaa aga gac aaa tgg att gag aat ctg cag cgg gca gta aag ccc      951
Ala Glu Arg Asp Lys Trp Ile Glu Asn Leu Gln Arg Ala Val Lys Pro         
            240                 245                 250                 

aac aag gac aac agc cgc cgg gta gac aat gtg cta aag ctg tgg atc      999
Asn Lys Asp Asn Ser Arg Arg Val Asp Asn Val Leu Lys Leu Trp Ile         
        255                 260                 265                     

ata gag gcc cgg gag ctg ccc ccc aag aag cgg tac tac tgt gag ctc     1047
Ile Glu Ala Arg Glu Leu Pro Pro Lys Lys Arg Tyr Tyr Cys Glu Leu         
    270                 275                 280                         

tgc ctg gat gac atg ctg tat gca cgc acc acc tcc aag ccc cgc tct     1095
Cys Leu Asp Asp Met Leu Tyr Ala Arg Thr Thr Ser Lys Pro Arg Ser         
285                 290                 295                 300         

gcc tct ggg gac acc gtc ttc tgg ggc gag cac ttc gag ttt aac aac     1143
Ala Ser Gly Asp Thr Val Phe Trp Gly Glu His Phe Glu Phe Asn Asn         
                305                 310                 315             

ctg ccg gct gtc cgt gcc ctg cgg ctg cat ctg tac cgt gac tca gac     1191
Leu Pro Ala Val Arg Ala Leu Arg Leu His Leu Tyr Arg Asp Ser Asp         
            320                 325                 330                 

aaa aag cgc aag aag gac aag gca ggc tat gtc ggc ctg gtg act gtg     1239
Lys Lys Arg Lys Lys Asp Lys Ala Gly Tyr Val Gly Leu Val Thr Val         
        335                 340                 345                     

cca gtg gcc acc ctg gct ggg cgc cac ttc aca gag cag tgg tac cct     1287
Pro Val Ala Thr Leu Ala Gly Arg His Phe Thr Glu Gln Trp Tyr Pro         
    350                 355                 360                         

gta acc ctg cca aca ggc agt ggg gga tct ggg ggc atg ggt tcg gga     1335
Val Thr Leu Pro Thr Gly Ser Gly Gly Ser Gly Gly Met Gly Ser Gly         
365                 370                 375                 380         

ggg gga ggg ggc tcg ggg ggt ggc tca ggg ggc aag ggc aaa gga ggt     1383
Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Lys Gly Lys Gly Gly         
                385                 390                 395             

tgc ccg gct gtg cgg ctg aaa gca cgt tac cag aca atg agc atc ttg     1431
Cys Pro Ala Val Arg Leu Lys Ala Arg Tyr Gln Thr Met Ser Ile Leu         
            400                 405                 410                 

ccc atg gag cta tat aaa gag ttt gca gag tat gtc acc aac cat tat     1479
Pro Met Glu Leu Tyr Lys Glu Phe Ala Glu Tyr Val Thr Asn His Tyr         
        415                 420                 425                     

cgg atg ctg tgt gca gtc ttg gag ccc gcc ctg aat gtc aaa ggc aag     1527
Arg Met Leu Cys Ala Val Leu Glu Pro Ala Leu Asn Val Lys Gly Lys         
    430                 435                 440                         

gag gag gtt gcc agt gca cta gtt cac atc ctg cag agt aca ggc aag     1575
Glu Glu Val Ala Ser Ala Leu Val His Ile Leu Gln Ser Thr Gly Lys         
445                 450                 455                 460         

gcc aag gac ttc ctt tca gac atg gcc atg tct gag gta gac cgg ttc     1623
Ala Lys Asp Phe Leu Ser Asp Met Ala Met Ser Glu Val Asp Arg Phe         
                465                 470                 475             

atg gaa cgg gag cac ctc ata ttc cgc gag aac acg ctt gcc act aaa     1671
Met Glu Arg Glu His Leu Ile Phe Arg Glu Asn Thr Leu Ala Thr Lys         
            480                 485                 490                 

gcc ata gaa gag tat atg aga ctg att ggt cag aaa tac ctc aag gat     1719
Ala Ile Glu Glu Tyr Met Arg Leu Ile Gly Gln Lys Tyr Leu Lys Asp         
        495                 500                 505                     

gcc att gga gaa ttc atc cgt gct ctg tat gaa tct gag gaa aac tgc     1767
Ala Ile Gly Glu Phe Ile Arg Ala Leu Tyr Glu Ser Glu Glu Asn Cys         
    510                 515                 520                         

gag gta gac cct atc aag tgc aca gca tcc agt ttg gca gag cac cag     1815
Glu Val Asp Pro Ile Lys Cys Thr Ala Ser Ser Leu Ala Glu His Gln         
525                 530                 535                 540         

gcc aac ctg cga atg tgc tgt gag ttg gcc ctg tgc aag gtg gtc aac     1863
Ala Asn Leu Arg Met Cys Cys Glu Leu Ala Leu Cys Lys Val Val Asn         
                545                 550                 555             

tcc cac tgc gtg ttc ccg agg gag ctg aag gag gtg ttt gct tca tgg     1911
Ser His Cys Val Phe Pro Arg Glu Leu Lys Glu Val Phe Ala Ser Trp         
            560                 565                 570                 

cgg ctg cgc tgc gca gag cga ggc cgg gag gac atc gca gac agg ctt     1959
Arg Leu Arg Cys Ala Glu Arg Gly Arg Glu Asp Ile Ala Asp Arg Leu         
        575                 580                 585                     

atc agc gcc tca ctc ttc ctg cgc ttc ctc tgc cca gcg att atg tcg     2007
Ile Ser Ala Ser Leu Phe Leu Arg Phe Leu Cys Pro Ala Ile Met Ser         
    590                 595                 600                         

ccc agt ctc ttt ggg ctt atg cag gag tac cca gat gag cag acc tca     2055
Pro Ser Leu Phe Gly Leu Met Gln Glu Tyr Pro Asp Glu Gln Thr Ser         
605                 610                 615                 620         

cga acc ctc acc ctc att gcc aag gtc atc cag aac ctg gcc aac ttt     2103
Arg Thr Leu Thr Leu Ile Ala Lys Val Ile Gln Asn Leu Ala Asn Phe         
                625                 630                 635             

tcc aag ttt acc tca aag gag gac ttt ctg ggc ttc atg aat gag ttt     2151
Ser Lys Phe Thr Ser Lys Glu Asp Phe Leu Gly Phe Met Asn Glu Phe         
            640                 645                 650                 

ctg gag ctg gaa tgg ggt tcc atg cag cag ttt ttg tat gag atc tcc     2199
Leu Glu Leu Glu Trp Gly Ser Met Gln Gln Phe Leu Tyr Glu Ile Ser         
        655                 660                 665                     

aat ctg gac acg cta acc aac agc agt agc ttt gag ggt tac atc gac     2247
Asn Leu Asp Thr Leu Thr Asn Ser Ser Ser Phe Glu Gly Tyr Ile Asp         
    670                 675                 680                         

ttg ggc cga gag ctc tcc aca ctg cat gcc cta ctc tgg gag gtg ctg     2295
Leu Gly Arg Glu Leu Ser Thr Leu His Ala Leu Leu Trp Glu Val Leu         
685                 690                 695                 700         

ccc cag ctc agc aag gaa gcc ctc ctg aag ctg ggt cca ctg ccc cgg     2343
Pro Gln Leu Ser Lys Glu Ala Leu Leu Lys Leu Gly Pro Leu Pro Arg         
                705                 710                 715             

ctc ctc aac gac atc agc aca gct ctg agg aac ccc aac atc caa agg     2391
Leu Leu Asn Asp Ile Ser Thr Ala Leu Arg Asn Pro Asn Ile Gln Arg         
            720                 725                 730                 

cag cca agc cgc cag agt gag cgg ccc cgg cct cag cct gtg gta ctg     2439
Gln Pro Ser Arg Gln Ser Glu Arg Pro Arg Pro Gln Pro Val Val Leu         
        735                 740                 745                     

cgg ggg cca tcg gct gag atg cag ggc tac atg atg cgg gac ctc aac     2487
Arg Gly Pro Ser Ala Glu Met Gln Gly Tyr Met Met Arg Asp Leu Asn         
    750                 755                 760                         

agc tcc atc gac ctt cag tcc ttc atg gct cga ggc ctc aac agc tct     2535
Ser Ser Ile Asp Leu Gln Ser Phe Met Ala Arg Gly Leu Asn Ser Ser         
765                 770                 775                 780         

atg gac atg gct cgc ctc ccc tcc cca acc aag gaa aag cca ccc cca     2583
Met Asp Met Ala Arg Leu Pro Ser Pro Thr Lys Glu Lys Pro Pro Pro         
                785                 790                 795             

cca ccg cct ggt ggt ggt aaa gac ctg ttc tat gta agc cgt cca ccc     2631
Pro Pro Pro Gly Gly Gly Lys Asp Leu Phe Tyr Val Ser Arg Pro Pro         
            800                 805                 810                 

ctg gcc cgt tcc tca cca gca tac tgc acg agc agc tcg gac atc aca     2679
Leu Ala Arg Ser Ser Pro Ala Tyr Cys Thr Ser Ser Ser Asp Ile Thr         
        815                 820                 825                     

gag cca gag cag aag atg ctg agt gtc aac aag agt gtg tcc atg ctg     2727
Glu Pro Glu Gln Lys Met Leu Ser Val Asn Lys Ser Val Ser Met Leu         
    830                 835                 840                         

gac tta cag ggt gat ggg cct ggt ggc cgc ctc aac agc agc agt gtt     2775
Asp Leu Gln Gly Asp Gly Pro Gly Gly Arg Leu Asn Ser Ser Ser Val         
845                 850                 855                 860         

tcg aac ctg gcg gcc gta ggg gac ctg ctg cac tca agc cag gcc tcg     2823
Ser Asn Leu Ala Ala Val Gly Asp Leu Leu His Ser Ser Gln Ala Ser         
                865                 870                 875             

ctg aca gca gcc ttg ggg cta cgg cct gcg cct gcc gga cgc ctc tcc     2871
Leu Thr Ala Ala Leu Gly Leu Arg Pro Ala Pro Ala Gly Arg Leu Ser         
            880                 885                 890                 

cag ggg agt ggc tca tcc atc acg gcg gct ggc atg cgc ctc agc cag     2919
Gln Gly Ser Gly Ser Ser Ile Thr Ala Ala Gly Met Arg Leu Ser Gln         
        895                 900                 905                     

atg ggt gtc acc aca gac ggt gtc cct gcc cag caa ctg cga atc ccc     2967
Met Gly Val Thr Thr Asp Gly Val Pro Ala Gln Gln Leu Arg Ile Pro         
    910                 915                 920                         

ctc tcc ttc cag aac cct ctc ttc cac atg gct gct gat ggg cca ggt     3015
Leu Ser Phe Gln Asn Pro Leu Phe His Met Ala Ala Asp Gly Pro Gly         
925                 930                 935                 940         

ccc cca ggc ggc cat gga ggg ggc ggt ggc cat ggc cca cct tcc tcc     3063
Pro Pro Gly Gly His Gly Gly Gly Gly Gly His Gly Pro Pro Ser Ser         
                945                 950                 955             

cat cac cac cac cac cac cat cac cac cac cga ggt gga gag ccc cct     3111
His His His His His His His His His His Arg Gly Gly Glu Pro Pro         
            960                 965                 970                 

ggg gac acc ttt gcc cca ttc cat ggc tat agc aag agt gag gac ctc     3159
Gly Asp Thr Phe Ala Pro Phe His Gly Tyr Ser Lys Ser Glu Asp Leu         
        975                 980                 985                     

tct tcc ggg gtc ccc aag ccc cct gct gcc tcc atc  ctt cat agc cac    3207
Ser Ser Gly Val Pro Lys Pro Pro Ala Ala Ser Ile  Leu His Ser His        
    990                 995                 1000                        

agc  tac agt gat gag ttt  gga ccc tct ggc act  gac ttc acc cgt      3252
Ser  Tyr Ser Asp Glu Phe  Gly Pro Ser Gly Thr  Asp Phe Thr Arg          
1005                 1010                 1015                          

cgg  cag ctt tca ctc cag  gac aac ctg cag cac  atg ctg tcc cct      3297
Arg  Gln Leu Ser Leu Gln  Asp Asn Leu Gln His  Met Leu Ser Pro          
1020                 1025                 1030                          

ccc  cag atc acc att ggt  ccc cag agg cca gcc  ccc tca ggg cct      3342
Pro  Gln Ile Thr Ile Gly  Pro Gln Arg Pro Ala  Pro Ser Gly Pro          
1035                 1040                 1045                          

gga  ggt ggg agc ggt ggg  ggc agc ggt ggg ggt  ggc ggg ggc cag      3387
Gly  Gly Gly Ser Gly Gly  Gly Ser Gly Gly Gly  Gly Gly Gly Gln          
1050                 1055                 1060                          

ccg  cct cca ttg cag agg  ggc aag tct cag cag  ttg aca gtc agc      3432
Pro  Pro Pro Leu Gln Arg  Gly Lys Ser Gln Gln  Leu Thr Val Ser          
1065                 1070                 1075                          

gca  gcc cag aaa ccc cgg  cca tcc agc ggg aat  cta ttg cag tcc      3477
Ala  Ala Gln Lys Pro Arg  Pro Ser Ser Gly Asn  Leu Leu Gln Ser          
1080                 1085                 1090                          

cca  gag cca agt tat ggc  ccc gcc cgt cca cgg  caa cag agc ctc      3522
Pro  Glu Pro Ser Tyr Gly  Pro Ala Arg Pro Arg  Gln Gln Ser Leu          
1095                 1100                 1105                          

agc  aag gag ggc agc att  ggg ggc agc ggg ggc  agc ggt ggc gga      3567
Ser  Lys Glu Gly Ser Ile  Gly Gly Ser Gly Gly  Ser Gly Gly Gly          
1110                 1115                 1120                          

ggg  ggt ggg ggg ctg aag  ccc tcc atc acc aag  cag cat tct cag      3612
Gly  Gly Gly Gly Leu Lys  Pro Ser Ile Thr Lys  Gln His Ser Gln          
1125                 1130                 1135                          

aca  cca tcc aca ttg aac  ccc aca atg cca gcc  tct gag cgg aca      3657
Thr  Pro Ser Thr Leu Asn  Pro Thr Met Pro Ala  Ser Glu Arg Thr          
1140                 1145                 1150                          

gtg  gcc tgg gtc tcc aac  atg cct cac ctg tcg  gct gac atc gag      3702
Val  Ala Trp Val Ser Asn  Met Pro His Leu Ser  Ala Asp Ile Glu          
1155                 1160                 1165                          

agt  gcc cac atc gag cgg  gaa gag tac aag ctc  aag gag tac tca      3747
Ser  Ala His Ile Glu Arg  Glu Glu Tyr Lys Leu  Lys Glu Tyr Ser          
1170                 1175                 1180                          

aaa  tcg atg gat gag agc  cgg ctg gat agg gtg  aag gag tac gag      3792
Lys  Ser Met Asp Glu Ser  Arg Leu Asp Arg Val  Lys Glu Tyr Glu          
1185                 1190                 1195                          

gag  gag att cac tca ctg  aaa gag cgg ctg cac  atg tcc aac cgg      3837
Glu  Glu Ile His Ser Leu  Lys Glu Arg Leu His  Met Ser Asn Arg          
1200                 1205                 1210                          

aag  ctg gaa gag tat gag  cgg agg ctg ctg tcc  cag gaa gaa caa      3882
Lys  Leu Glu Glu Tyr Glu  Arg Arg Leu Leu Ser  Gln Glu Glu Gln          
1215                 1220                 1225                          

acc  agc aaa atc ctg atg  cag tat cag gcc cga  ctg gag cag agt      3927
Thr  Ser Lys Ile Leu Met  Gln Tyr Gln Ala Arg  Leu Glu Gln Ser          
1230                 1235                 1240                          

gag  aag agg cta agg cag  cag cag gca gag aag  gat tcc cag atc      3972
Glu  Lys Arg Leu Arg Gln  Gln Gln Ala Glu Lys  Asp Ser Gln Ile          
1245                 1250                 1255                          

aag  agc atc att ggc agc  ccg tcc ctt cag gct  gat gct ggt gga      4017
Lys  Ser Ile Ile Gly Ser  Pro Ser Leu Gln Ala  Asp Ala Gly Gly          
1260                 1265                 1270                          

gga  gga gct gcg ccg gga  cca ccc cgc cat ggc  tga gccgctgcca       4063
Gly  Gly Ala Ala Pro Gly  Pro Pro Arg His Gly                           
1275                 1280                 1285                          

gaacccaaga agaggctgct cgacgctcag agaggcagct tccccccttg ggtccaacaa   4123

acccgcgtgt gacgctggcc ccaccgtgga atggcctggc ccccccagcc ccaccacccc   4183

caccccggct gcagattacg gagaacggcg agttccgaaa caccgcagac cactagccca   4243

cccagcatca gagaccttct cttcctttcc tgtgcacccc accctgtaac agcaccaacc   4303

accaggattg gacatcaccg aggaacagcg ggattgcctc cccgaatgcc tccctgggag   4363

gcacactgat tgcccacccc caccactgca ccatttccag gagggagagt ggggaccctc   4423

agccgccccc ttttccttcc cattggggtg ctgccctctc tttgaccccc agggaccctt   4483

gccccaggac accgcctacc ccgtacagac cccttcactc cggggtgcta tccccatcct   4543

ctgcctcatc gttcccctga gcactggggg acagaccctc acccccaccc tgggggtgtg   4603

gcacctccaa actttcaact tcagggtgat ttttttagca gtaaccagag ctgacaatct   4663

aactcccctc caccgcccca ttttggcctc ccctgccccc cttgttatgg ggaggggacc   4723

ccgggtgagg gggccctatt accccttgat ttctcaggag cgtctggggg ggctcagcac   4783

gcacaaactc cttctccttc taccactctt aaatttactc cctccccacc cagaacccag   4843

atggggtgga gggggccacc ggggcaggga gggggcggca aggggggaat gggagttgtc   4903

tccccttctc cccacacctg atctgctctc ggctggtccc agagcggggt gagggggctt   4963

atgccccccc ctcccccagt gtgttgggtg gggtggaatt gaggttaggg tgaggggtca   5023

gggtttggga gggtgtgtat gttgggagga caggctagtt gatctgtcct actctgacac   5083

acagtcccct ctgccccttc cttctctctt cttggtctct actcccaggg ggagggggga   5143

acttactcta ggaaaagcca tgtctctctc ccccagggtg gggggacctg tgttggagga   5203

ggggtgttgg ggggccccct tccatgactc tgtcccctgg gggaggtagg acagggctgg   5263

gcttccctct catcctcccc ctcccaatct ccttccacct ccctccctcc cgccagctcc   5323

acgatttttc ggtgtttctc tgtacatagt tttctggcgg gataggggag gtaggatgga   5383

tggggtttgg ggtgggtagg ccatgggagg ggagaagccc ctccttggca ccccctcttc   5443

cctgactgct gtcccctacc cagccttgcc cccttcatcc ttttgcgttt ggtattgaga   5503

ctctcctaga ctctactcct ctttcttttg tatggacagt tccccttcag tcccatcccc   5563

ctacacatac acccagccgg ggccaaattt atacttatat aaaagttgta aatatgtgaa   5623

attttatccc tgtgcccttt ccccacctca ggccctaccc ctggaccctc cccaaccttc   5683

cttctctctt ctttggctgt tgtaattatc tggggtttgt actgtacata tccggggtgt   5743

gtgtgtgtgg gctgggggca acccttctgt acagagcttc ctggccccct ccccccccgc   5803

ccctctgctt ccctccccac ccaccacctc aagggtaggg agttgctctt cctacctgtt   5863

ttattttgtt ttctcgttct ccctccccac cccactccca gccttatcta tcccccctca   5923

ctgtcccctt ttctccactc ccagccccat ttcctttttt tctggagtgt gtggtgaaac   5983

agaaaaaaac atgtttaata aacggagatt gttcttttaa gaaaaaaaaa aaaaaaaaaa   6043


<210>  6
<211>  1285
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Arg Ser Arg Ala Ser Ile His Arg Gly Ser Ile Pro Ala Met 
1               5                   10                  15      


Ser Tyr Ala Pro Phe Arg Asp Val Arg Gly Pro Ser Met His Arg Thr 
            20                  25                  30          


Gln Tyr Val His Ser Pro Tyr Asp Arg Pro Gly Trp Asn Pro Arg Phe 
        35                  40                  45              


Cys Ile Ile Ser Gly Asn Gln Leu Leu Met Leu Asp Glu Asp Glu Ile 
    50                  55                  60                  


His Pro Leu Leu Ile Arg Asp Arg Arg Ser Glu Ser Ser Arg Asn Lys 
65                  70                  75                  80  


Leu Leu Arg Arg Thr Val Ser Val Pro Val Glu Gly Arg Pro His Gly 
                85                  90                  95      


Glu His Glu Tyr His Leu Gly Arg Ser Arg Arg Lys Ser Val Pro Gly 
            100                 105                 110         


Gly Lys Gln Tyr Ser Met Glu Gly Ala Pro Ala Ala Pro Phe Arg Pro 
        115                 120                 125             


Ser Gln Gly Phe Leu Ser Arg Arg Leu Lys Ser Ser Ile Lys Arg Thr 
    130                 135                 140                 


Lys Ser Gln Pro Lys Leu Asp Arg Thr Ser Ser Phe Arg Gln Ile Leu 
145                 150                 155                 160 


Pro Arg Phe Arg Ser Ala Asp His Asp Arg Ala Arg Leu Met Gln Ser 
                165                 170                 175     


Phe Lys Glu Ser His Ser His Glu Ser Leu Leu Ser Pro Ser Ser Ala 
            180                 185                 190         


Ala Glu Ala Leu Glu Leu Asn Leu Asp Glu Asp Ser Ile Ile Lys Pro 
        195                 200                 205             


Val His Ser Ser Ile Leu Gly Gln Glu Phe Cys Phe Glu Val Thr Thr 
    210                 215                 220                 


Ser Ser Gly Thr Lys Cys Phe Ala Cys Arg Ser Ala Ala Glu Arg Asp 
225                 230                 235                 240 


Lys Trp Ile Glu Asn Leu Gln Arg Ala Val Lys Pro Asn Lys Asp Asn 
                245                 250                 255     


Ser Arg Arg Val Asp Asn Val Leu Lys Leu Trp Ile Ile Glu Ala Arg 
            260                 265                 270         


Glu Leu Pro Pro Lys Lys Arg Tyr Tyr Cys Glu Leu Cys Leu Asp Asp 
        275                 280                 285             


Met Leu Tyr Ala Arg Thr Thr Ser Lys Pro Arg Ser Ala Ser Gly Asp 
    290                 295                 300                 


Thr Val Phe Trp Gly Glu His Phe Glu Phe Asn Asn Leu Pro Ala Val 
305                 310                 315                 320 


Arg Ala Leu Arg Leu His Leu Tyr Arg Asp Ser Asp Lys Lys Arg Lys 
                325                 330                 335     


Lys Asp Lys Ala Gly Tyr Val Gly Leu Val Thr Val Pro Val Ala Thr 
            340                 345                 350         


Leu Ala Gly Arg His Phe Thr Glu Gln Trp Tyr Pro Val Thr Leu Pro 
        355                 360                 365             


Thr Gly Ser Gly Gly Ser Gly Gly Met Gly Ser Gly Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Ser Gly Gly Lys Gly Lys Gly Gly Cys Pro Ala Val 
385                 390                 395                 400 


Arg Leu Lys Ala Arg Tyr Gln Thr Met Ser Ile Leu Pro Met Glu Leu 
                405                 410                 415     


Tyr Lys Glu Phe Ala Glu Tyr Val Thr Asn His Tyr Arg Met Leu Cys 
            420                 425                 430         


Ala Val Leu Glu Pro Ala Leu Asn Val Lys Gly Lys Glu Glu Val Ala 
        435                 440                 445             


Ser Ala Leu Val His Ile Leu Gln Ser Thr Gly Lys Ala Lys Asp Phe 
    450                 455                 460                 


Leu Ser Asp Met Ala Met Ser Glu Val Asp Arg Phe Met Glu Arg Glu 
465                 470                 475                 480 


His Leu Ile Phe Arg Glu Asn Thr Leu Ala Thr Lys Ala Ile Glu Glu 
                485                 490                 495     


Tyr Met Arg Leu Ile Gly Gln Lys Tyr Leu Lys Asp Ala Ile Gly Glu 
            500                 505                 510         


Phe Ile Arg Ala Leu Tyr Glu Ser Glu Glu Asn Cys Glu Val Asp Pro 
        515                 520                 525             


Ile Lys Cys Thr Ala Ser Ser Leu Ala Glu His Gln Ala Asn Leu Arg 
    530                 535                 540                 


Met Cys Cys Glu Leu Ala Leu Cys Lys Val Val Asn Ser His Cys Val 
545                 550                 555                 560 


Phe Pro Arg Glu Leu Lys Glu Val Phe Ala Ser Trp Arg Leu Arg Cys 
                565                 570                 575     


Ala Glu Arg Gly Arg Glu Asp Ile Ala Asp Arg Leu Ile Ser Ala Ser 
            580                 585                 590         


Leu Phe Leu Arg Phe Leu Cys Pro Ala Ile Met Ser Pro Ser Leu Phe 
        595                 600                 605             


Gly Leu Met Gln Glu Tyr Pro Asp Glu Gln Thr Ser Arg Thr Leu Thr 
    610                 615                 620                 


Leu Ile Ala Lys Val Ile Gln Asn Leu Ala Asn Phe Ser Lys Phe Thr 
625                 630                 635                 640 


Ser Lys Glu Asp Phe Leu Gly Phe Met Asn Glu Phe Leu Glu Leu Glu 
                645                 650                 655     


Trp Gly Ser Met Gln Gln Phe Leu Tyr Glu Ile Ser Asn Leu Asp Thr 
            660                 665                 670         


Leu Thr Asn Ser Ser Ser Phe Glu Gly Tyr Ile Asp Leu Gly Arg Glu 
        675                 680                 685             


Leu Ser Thr Leu His Ala Leu Leu Trp Glu Val Leu Pro Gln Leu Ser 
    690                 695                 700                 


Lys Glu Ala Leu Leu Lys Leu Gly Pro Leu Pro Arg Leu Leu Asn Asp 
705                 710                 715                 720 


Ile Ser Thr Ala Leu Arg Asn Pro Asn Ile Gln Arg Gln Pro Ser Arg 
                725                 730                 735     


Gln Ser Glu Arg Pro Arg Pro Gln Pro Val Val Leu Arg Gly Pro Ser 
            740                 745                 750         


Ala Glu Met Gln Gly Tyr Met Met Arg Asp Leu Asn Ser Ser Ile Asp 
        755                 760                 765             


Leu Gln Ser Phe Met Ala Arg Gly Leu Asn Ser Ser Met Asp Met Ala 
    770                 775                 780                 


Arg Leu Pro Ser Pro Thr Lys Glu Lys Pro Pro Pro Pro Pro Pro Gly 
785                 790                 795                 800 


Gly Gly Lys Asp Leu Phe Tyr Val Ser Arg Pro Pro Leu Ala Arg Ser 
                805                 810                 815     


Ser Pro Ala Tyr Cys Thr Ser Ser Ser Asp Ile Thr Glu Pro Glu Gln 
            820                 825                 830         


Lys Met Leu Ser Val Asn Lys Ser Val Ser Met Leu Asp Leu Gln Gly 
        835                 840                 845             


Asp Gly Pro Gly Gly Arg Leu Asn Ser Ser Ser Val Ser Asn Leu Ala 
    850                 855                 860                 


Ala Val Gly Asp Leu Leu His Ser Ser Gln Ala Ser Leu Thr Ala Ala 
865                 870                 875                 880 


Leu Gly Leu Arg Pro Ala Pro Ala Gly Arg Leu Ser Gln Gly Ser Gly 
                885                 890                 895     


Ser Ser Ile Thr Ala Ala Gly Met Arg Leu Ser Gln Met Gly Val Thr 
            900                 905                 910         


Thr Asp Gly Val Pro Ala Gln Gln Leu Arg Ile Pro Leu Ser Phe Gln 
        915                 920                 925             


Asn Pro Leu Phe His Met Ala Ala Asp Gly Pro Gly Pro Pro Gly Gly 
    930                 935                 940                 


His Gly Gly Gly Gly Gly His Gly Pro Pro Ser Ser His His His His 
945                 950                 955                 960 


His His His His His His Arg Gly Gly Glu Pro Pro Gly Asp Thr Phe 
                965                 970                 975     


Ala Pro Phe His Gly Tyr Ser Lys Ser Glu Asp Leu Ser Ser Gly Val 
            980                 985                 990         


Pro Lys Pro Pro Ala Ala Ser Ile  Leu His Ser His Ser  Tyr Ser Asp 
        995                 1000                 1005             


Glu Phe  Gly Pro Ser Gly Thr  Asp Phe Thr Arg Arg  Gln Leu Ser 
    1010                 1015                 1020             


Leu Gln  Asp Asn Leu Gln His  Met Leu Ser Pro Pro  Gln Ile Thr 
    1025                 1030                 1035             


Ile Gly  Pro Gln Arg Pro Ala  Pro Ser Gly Pro Gly  Gly Gly Ser 
    1040                 1045                 1050             


Gly Gly  Gly Ser Gly Gly Gly  Gly Gly Gly Gln Pro  Pro Pro Leu 
    1055                 1060                 1065             


Gln Arg  Gly Lys Ser Gln Gln  Leu Thr Val Ser Ala  Ala Gln Lys 
    1070                 1075                 1080             


Pro Arg  Pro Ser Ser Gly Asn  Leu Leu Gln Ser Pro  Glu Pro Ser 
    1085                 1090                 1095             


Tyr Gly  Pro Ala Arg Pro Arg  Gln Gln Ser Leu Ser  Lys Glu Gly 
    1100                 1105                 1110             


Ser Ile  Gly Gly Ser Gly Gly  Ser Gly Gly Gly Gly  Gly Gly Gly 
    1115                 1120                 1125             


Leu Lys  Pro Ser Ile Thr Lys  Gln His Ser Gln Thr  Pro Ser Thr 
    1130                 1135                 1140             


Leu Asn  Pro Thr Met Pro Ala  Ser Glu Arg Thr Val  Ala Trp Val 
    1145                 1150                 1155             


Ser Asn  Met Pro His Leu Ser  Ala Asp Ile Glu Ser  Ala His Ile 
    1160                 1165                 1170             


Glu Arg  Glu Glu Tyr Lys Leu  Lys Glu Tyr Ser Lys  Ser Met Asp 
    1175                 1180                 1185             


Glu Ser  Arg Leu Asp Arg Val  Lys Glu Tyr Glu Glu  Glu Ile His 
    1190                 1195                 1200             


Ser Leu  Lys Glu Arg Leu His  Met Ser Asn Arg Lys  Leu Glu Glu 
    1205                 1210                 1215             


Tyr Glu  Arg Arg Leu Leu Ser  Gln Glu Glu Gln Thr  Ser Lys Ile 
    1220                 1225                 1230             


Leu Met  Gln Tyr Gln Ala Arg  Leu Glu Gln Ser Glu  Lys Arg Leu 
    1235                 1240                 1245             


Arg Gln  Gln Gln Ala Glu Lys  Asp Ser Gln Ile Lys  Ser Ile Ile 
    1250                 1255                 1260             


Gly Ser  Pro Ser Leu Gln Ala  Asp Ala Gly Gly Gly  Gly Ala Ala 
    1265                 1270                 1275             


Pro Gly  Pro Pro Arg His Gly  
    1280                 1285 


<210>  7
<211>  33620
<212>  DNA
<213>  Homo sapiens

<400>  7
tctcggctgc cgctgctgcc gttggctctt attctcctcc tcctcctcct ctctcctcct     60

ctctgcttct ctctgctcct ctctcctcct ctctcctcct cctcctcctc cacctcctcc    120

tccttctccc cctctttctc cccctctttc tctcttcttt ctcccccgtc cccccgcccc    180

ctccccccag gcctgatgag caggtctcga gcctccatcc atcgggggag catccccgcg    240

atgtcctatg cccccttcag aggtacgtgg tggggggagg gggagggcca tatggggggc    300

aacaggggga ggggcagggg gcgggggaga gtcggggccg agggaaggga gcggctgaaa    360

tggagggaga ggggaggacc gggaaggcag gggtgggagc aaccgggaag gagggattgg    420

aggccagagg gataggggta gataagggat ggaggggcca ggaaatgggc cttgaaaggg    480

ggctgaaggg aaaatgatga aggggaaaga aagcgccaga aaggggtggg aaggtagaag    540

gattgggttg gggaaaaagc tgcagaaata atttgggggt gggagctgag tgatgaggaa    600

aacatcaagg aaatagaggg acagagtctt gggagagggg ctaggaagga gaaatgaaaa    660

cataggggtg aaaagagaag ccaagaagat gtggggggat aatttggtgg gggactcaga    720

gtatggtaag gggcggaaaa agagaggagg atggagggag agaaggggcc agatggagag    780

agagggaggc agtggggggt ggggggatgg agggtccaga tggagggaag agagaagaga    840

gagggaacgg tgggggaggg gagaccaggg cagggggagg gccaaattat gtgtgcttgg    900

gggggtggca gtacaagtaa gatgaaatga tgggagtagg ggacaggtta ggatcctgcc    960

ccagactctg accctcttaa aggctcttga ccagtaaaat gtaacctctg gggtcttaat   1020

gctgtcttca cttcatcact tttaccccct tcccccaccc ctccaatcct tatttccatt   1080

ccccctccct cctctgctgt ccatcaccta tatctttccc cccatatggt gtccgttcct   1140

tatatgagtc ccccttctgt ccttccccta tatcagtccc ctctctggtg ttcattgcct   1200

ctctcttatc tcttttctat gtggtcgctc ccttatatct ctatcacttc tttactagtc   1260

cgtcttgacc ccttctcata gcctccgcat taggtctgcc tcctttgctc tgacacatgt   1320

ccagtcgagc ccttcaggtg tattcccttg cccctgggca tttaccatca tttctgcctc   1380

cttttctatc tactcctatt atttgtctcc cagaccattc cttgtcacca caagtctgtg   1440

cctacccact ttcccttaat acctcaactc ttattatcat ttctcttttc ttgtctcctc   1500

tacttattgg ggtgttggag atttggggta caaagacaca ggttttgatg attagaacaa   1560

gggatcccca tctcagccct tgagggattt ctcatcctag taaaaatttc ccgtttctca   1620

gccatgttgc tctgcctctt gcatctgcct cccagaatca ttcttcacca agtccagaca   1680

gtatgtgtgt gtgtgtttct agagttgttc ctaagttccc tgctgccagg agaaagatgc   1740

cctctgaagt ctaacccgcc tcccttggct gcagcctgaa ccagcccttt ccccaaatgc   1800

ttatgtgtat caacagattt ctcctctggg tataccaagt gtctaagtgc ggtgggcatg   1860

ttgcctgcaa tgtctgtagt ttcagaggct aggtattggt gatctctgta tctagagaac   1920

attagttagt ctctgagatg ggttgagata gagtttcaaa gtatgtggtt tctaaatggt   1980

ggacattctg agggttcatc gctcactgtg atctggaggt tgggtaaatt tgagagacat   2040

atttatagac agaaaagggc tgaatttgca aaactctgct actcagtgca ttctgttgga   2100

atgaagctca aagaccagtt ctcctgcagt atactcatgg ttatcccata aaggtgacag   2160

agtttgatct tttttccatc taaaatctga taccttaagc ctaatttcta gctctttgct   2220

gtcgccaatg tgacatctct cttacttcaa tagggcctgt gtggcattgg ggtttaaagg   2280

agaggcagtt tgcagggaga gcggcatggc aagaacaaca gagctgggga aggaggaccc   2340

tggtctcatc tcagccatag gcgacacttg gtctactgtt ctctcttctc aaagttttgt   2400

tcccatctcc agctcttgtc tttggaggcc cctctgtgtc accaggcctg gatattccat   2460

tctttccccc tgacatcttt cttcctcaag ctcctcactg tgccttgaga aggctcctga   2520

cctatggagt ggcttccatc ctgtccactg agactaggtg gggtgaggtg gtgggggcag   2580

tgttgaatct ctgggcactg aatgggagaa gagataaatt tggtctctac ttgtccaaac   2640

aagggcatat ttcccacctt ctgccctggg gcctccacag ccagatgccg acaaaagcca   2700

tcttctcctt accaccagaa gaaccagaac tttccctaaa ggatgagcag ggttgaacta   2760

ggggaggagg gcacagagga gggaagagtt gggaggggag gccctctcat gtctctgact   2820

gtgaacaggt aagctccccg acttcttctt ttctagatat ttagccctca gaatctcatg   2880

atcccaatgt tcctacacac acaccccatc cttctttccc acagccatgt agctttcctc   2940

atactctttt atagaggggt ggtgccacct tccaagtcct tgtcttctgc agctatttgg   3000

atgccttcct ctacccagat atctgacacc aacttctctg tttttctcct gccaattttg   3060

cggcacctct accttatttt cctgaagtag atggagagct ccttcatctt tctctgcccc   3120

caaacgtgta ccttctctgt catataattc ccatccctga acctctgcat ttcttccccc   3180

aagtctccag agccttctgt gatgtgatcc tctcctcttt tcccctttgt ataaatgctt   3240

gtcttgtgtt cctttagagt tgccaggtgt ctcactttca actgtgatct cctgaaggcc   3300

ggtagggtcc ccttctcact ttgtggactc tcttcttgcc attttaggcc tctgcttcca   3360

aatgcataga gcctccctta ctgtttctgt gtgtctctgt cctccagatg tacggggacc   3420

ctctatgcac cgaacccaat acgttcattc cccgtatgat cgtcctggtt ggaaccctcg   3480

gttctgcatc atctcgggga accagctgct catgctggat gaggatgagg tgagtgtggt   3540

gagaaggctg ggaaaacgca tgtgggagaa tggggagagt cctcattagt gaaggggaga   3600

gagacacaaa gaaggcagac aaagaagaaa catttgcaaa tggcaggagg gtggccattg   3660

agacttgggt tggagtgtga caagaggggt agtcattctc tcatcttggg cagggagtct   3720

ttgagggtta tgagctgtgt tggggaggag atgtggttct gaagatttcg ggggtgggga   3780

ggctcctgtt ttcacactgt ccatattgta ggataggtta gaatggggaa ggggaactga   3840

agggtttgga gaaggggtga agacatggaa ggccctccca accaaagcaa tcctcaggac   3900

ccctctctgc tttgcccact gagcaagact cccagtcctt tctccatcag ggggcagagt   3960

gcaagaagag aaattgcagg acgcagagaa aaggcagggg atagaggagg ttttaggtag   4020

ctggaggata ctgggaaaga agactgaggt cagtggatct tggcatgatg gggtgaagac   4080

tgggagagtg attgagatca aggtttagag agacactgag agggcttctg caagggagtg   4140

gttggacatc aggaaggaat ataagggagg ggaactggga gtatgtggag ttatctaaag   4200

gagtacaagt ggagtagggg cagggactag ccagagtaaa ggagatgaaa cggacagagg   4260

cctcttatgg gaggtggtgg ccaggtatgg agatctgaga gccagggaag tgtgggttct   4320

gatttgggag ctgggtcagc aggagtgtcc attggaggaa atagaggata aaaactggaa   4380

tggtgcccca caagtgtgag tcagggaatg ggggtgattt gggggacaag ctttaaaaaa   4440

tggtagggta gcctggaaaa ccaaacgtgg tgagagatgg accctgaaag ttattgggaa   4500

tggtgtgatg aggaagggtt agaatttgag tcagggctaa ctagagtgtc aagggaccta   4560

tgggggcagg tgagagtgtg gagagatggc tgggtagaca gcttccaggc cacagagtaa   4620

agtagaggtg ttaaggagag gatatggtga ctttgaaagg agaggtggct tggggagtct   4680

aagttttgga caccattggg agacatttga gtgactgtgg tcaaacccct agatcaaggt   4740

ttggagtctg taggagaaat gggggaaact ggaacccaga gtggggactg ttatagggat   4800

gaagagggaa gacaatggat tggggtaatg aaggaatgac agagataggg acagactgaa   4860

gggaccagtg gccagcaagt tgaggggcaa taggaatggc cggtctggag caggaagggc   4920

gtgtgtgtgg gaggaggagt agatagaatt gggaaaatga gcagcctgaa cagacgcagg   4980

gagttggaat tggatgggtg gtggaactgg ggctggggga tagtgagggg tctgttcctg   5040

tggctctttg tagaggtgga ggagactgca ggggtggagg tgtatggagg tagggatgga   5100

ggtggacagg gggagctggg tgtgaagctt agggaaaggt gatggctgag gggaagaagg   5160

gaactgagag atgctgggtc gggtgatgga aggagatgaa aggtggggga aggtgaccag   5220

gccctctggc gggaggggag gttgggtccc agtctggccg caagccgggc cgtgggaggg   5280

agacaagctg tggatcctga ttataaatgc agcttctgct acccccgtga caggctcgga   5340

gggagagaag ggggtaaggg aggtgggagg ttgggaggaa agcagggaga atggaggaac   5400

tgaaggtcaa gggaaaactg gattcaggaa gtagctaact tctgaggagt tgcagaagag   5460

ctgagtaggg tttgggagaa ttctccggaa ggtgtttcaa gacaaatgga gggagaaaag   5520

agggtgggac ggcaaagaat gagagagaga gactggggga gagaagggag agatccagtc   5580

accaagtgtg gaggggccgg ggcagaaaaa gtgggcaggc ttagggggaa aaggaggccc   5640

gcccttcctg ggaggaggcg gaggggggaa gagggagggg aggggcggcg tgggccaggg   5700

aggtctgaca cacccccacc tcccctagat acacccccta ctgatccggg accggaggag   5760

cgagtccagt cgcaacaaac tgctgagacg cacagtctcc gtgccggtgg aggggcggcc   5820

ccacggcgag catggtacgg cggccgagca ggctctcatg acccggacag gcgcggggag   5880

agggctgaag atggaccggg ctggcggggc gggggcgtcg gggagcggcg ggagctggcc   5940

gggggcggga gaaggcggag acaaagtctt gcttcccgag gggagatggc gccctcctct   6000

ggaaggtgga gcgggacagg ggctgtgggt gagaggcccc tgtgggtcct cgctcggctt   6060

cgctcccttt ctcctctcca gcagtgaagt ttgactattt tcctggtgct tgtaaaaata   6120

gtctccttag atctttagct tccagtccgt gtgttcctgc ccctgcccct cccagcccct   6180

ggtctgggat cttggaaaga atgacctagt tcctgccctc cccccagacc tcttccccac   6240

ccctatgctc ctgattcttc ttccggacct tcagtccttg aggtctcctt ttattacccc   6300

ctgttttctc ctctcatcag ctgcttctat tttctgcaat tgtatcaccc tttctctttc   6360

ctccctgatt tctcttattt tctgtacccc tcttgattac cccgtccctc ccctctgctc   6420

ccggcgaaag tccatcagac tcccatctca tctcctttct gtctgtagag ctatctgcgc   6480

ggtctgtctc tccaactctc tccctctctc catctgtctc ttcccctccc tccccctttc   6540

tgccccccca accccctctt tagtcattta aaaaaagatt tttgtcttcc tgagaagttc   6600

gcttaaaagg tttccatggg aacagtgagg ggagatgaag gcagagaaca gagatctgca   6660

gccaaggtgc agagagacgc cctcagcccc cggaaacccc ctcgtcactg cccccttcca   6720

cttcatttcc cttcccggac ctagcgatcc aggttcccca ttcctccaac ccccaggtga   6780

cccctttttc ccaccagctc cccctccctt caggaattca agctaccagt ttctctccct   6840

tagagagcca gtgacctgtc cccatccttt ggctccttcc agccttctga taggtccagg   6900

ccctactagc cttgtgggcc ggtttgggga ccttgggtgg gtgggtgggt ggtcagggat   6960

gtgtgtcatt gtcatggaaa ccccatacca tcggggtgtg tgggtagcac atctctgtga   7020

ggcaaagtca ggtggtggtg gagtgtatac agagaatgtg tgtgatgtct gtcacatctg   7080

tgtgtatatg tatatgtgtg tatgtcatgt tcatgtctgg ggaagatgtg tgtgtttgtg   7140

tgcatgtgtg tacacctgcg tttccaggcc agaatggtca catgctcaca gagcatgttt   7200

atcatgtgtc ctgtggttgg cagatctgcc cacttattcc ccatctttct ccttatcctg   7260

agtcctcagg gtctaggggt ctctggcggg ggtctcccgt gtgttttggg tggggacacc   7320

gtgtgtgttt ggagttgagg tggcatgtgg aggttgctgt attggggttc agtaggggct   7380

gggaggggtt ccaggggcat atgtatttgg ggggagggct tagtgaaagt tgatgggggt   7440

gaacgtttag ggtcttcagg cagacatgga atgtgtaaag ggcatggagg atgtgcagtg   7500

gacatagggg tcgttgggac cttggggact tggcaatgcc aaggtgtttg ctgaggctgt   7560

ggactctcca gcccgggaga ggtcgccgga cctttgaggg gcattggaat cctgggctcc   7620

tcctctgctg ggtggagccg cgaaccctcg ttctctccgc ggttttgtgt gtgtgggggg   7680

gtcctgctca ggaggggatg gtgggtggcc tggtttgttt tgggggtccc cttgcccccc   7740

tcccccgtct ctctcgcgct gtctccgggc gacagggctc gtgacagagg cggccacggc   7800

agcagcggtc gcctagcaac ggcggcgggg cccgggcaac ggcggcagcg gcgggagcgg   7860

cggcggaggg agccgttccc gcggccgtca ccgcgcggcc gtcccggccg tcccgggccc   7920

cgccgccgcc cccaccgcgc cgggcggcgc gagccgggcc gtaccgcccc ctctccctcc   7980

gcaccccgcc cttcccccgc gcaggggcgg ggcccctccc ccaccgggga cacccctggc   8040

ccccccgggg ggcggtgcga ggtaagggcg gggccgggcg gactaggagc gcgcgtagag   8100

gggggggcgc cgcgcgcgtg gggcgggggc gcgcgtgtgc gtgggcgcgg ggaggggggt   8160

ggggaagccg cggtggcggc ggcggcggcg gcagctgctc cctccgcatg ttctcgctgc   8220

atcttccgag tggggggagt tatggtaacc ggagggggac agcggaggac gggagggtcg   8280

gggaccggcc tcgtgcggac agggtcttga gcacgcgggg gcggccggtg tgtgtgggat   8340

cttggagccc ctggtggaag gggcagcccg tgtgtccgcg tgtgtgttcg tgcccatgct   8400

cgtgtctcct gtgtgtcggt gccatgtgca cacgggggcc cagttcctcg tgcacacatg   8460

tgcagccatc cttgtgcaag tgtgtcctgt cttatcttgc ctctgcctgt ttcctgccta   8520

gggggctgtt gggccagcca cgggcttgtg gggcagtccg cggccttgct ggtccatgtc   8580

acctctgacc ctgagcatgc atatccctgg ctggggctca cctcctgtca ggcttctgtg   8640

tgtgggaatg tgtggcccta tgagcaggat tttctgtgtc cctggtggca ggtgtgtgtc   8700

tttgcatgtg tgttccagca ctggcctgag tatctgtgtc aatcccagca tgggtgtcca   8760

gggcgtgtct ggatgtgggt ggtgtggctg gggggagtaa gtgtgtgaat gtgttccttg   8820

gaattctact gtgtatgaaa cacctttggg ctgggcaggt gtaagccctg cttggtcagt   8880

aagtggggac agaaaagctt aaaaagggaa gaaatggggt aaagaggaaa agtggggagg   8940

ggataggaga gaaggaatga gagaggcttg aagaagagag cagagagcag caggccaggg   9000

agaaagaata gctggagaat gggaatgtgg gagaaagcca agccagactt agaagagaga   9060

acaggggata agagcttaag atggggaact ggatagagat ggtgggagaa gaaggggtct   9120

gggagctggg gaggcagtgg ggaggagaga gtcaggcctt ctggtaaagt gatctctgaa   9180

agaagaaagg gaagaagatg ggagaaggca ctggattctt gtaggccttg caggatcagg   9240

cttggttttg gatcagggaa ggccactcag gcatacgggc tggctcacag tgaggcctgt   9300

catagcaggg actgtcatta gaggttcata tccccagcac agagctctgt ctcccatttc   9360

tctgctctgt gtccaaccct gttcttcgcc cttctctggc aacctccctc ctctggctcc   9420

ccttgagagc tgccagctgg gtgtggagag gaagaaaggc caaagggaag gttagggatt   9480

tggagggcag ggggagattc tgtgggtgat ggcaagatta gagatgttgg aggggcagga   9540

gtccaagccc ttgctgtgtg tgtgtgagtg ccattgtgtg tgtacacagg gtgtgtacat   9600

gtgtgggtgt gtgcacaatg cctgtgttac gggtttgtgt aggtggctgt tatgtgtgtg   9660

catgcgtgta tacatcgtgc aggcatggga catggagacc caggatcaca gtttgtgctt   9720

ttcaggtttg ctgtgtgtgt gtgtacacgg gtgtgtgttg ttttctctgt acatgtcact   9780

gcatgcagca ttaataacag gatgttctgt gtttctgtca ctctgccccc cctttcctct   9840

gtgtttctgc tattcttttc ctgcggcaac aaaagtgttt aataagcata tgtgtatgtg   9900

gcctctgtgt acctgtgact tatgagtgag ttcatggatc ttagttcttg gtaatatgtg   9960

taaggttata ttacttccaa gaaccaagca agccaattag caaatttgtt cttctgttaa  10020

tgctttagtt ccaaagcgga attttaatgc atttaaagtt agactttatg cctttattag  10080

atgagcttgc acatgaaaat aatggctgag ctcggttccc tgaaatgaga gtgaggcagc  10140

catacctgag aaatgcagaa aaaatgttac tagggaagag atatcctgaa ccattggatg  10200

cattgcttag tgtgtaccag aaggataatt aacacatttg ctcctggttt ttctttactc  10260

tggtggcaat ctcggatgcc tgtgttagag tgagagaagg gctgggggag gaaagggggt  10320

tgtcctgaga cagagtggat gtggttgtac ttttcacgtg aatgaaagga tgtttgtgct  10380

tctgagatat ggggatacct ttctgtggtc aggatcatgg tgtactcaag catgtatttc  10440

aggggttaaa ctggaattcc cctgcatggg gatatgtgtg tcttagggtt ataggtccat  10500

ttctgtagtg tgctgtccac atgattgccc aagagacttg ggccacaaag tccacaccag  10560

cagctctcat gtgggtcact gggttcaagt atgtactccc ttgttgcaga gctcacatat  10620

gtcaaagcat gtatcctgtg gggtgtgtgg gcctcagggt ctcagaatgt ggatccgtgc  10680

tatgcccgtg ctcacagttg tctgtatgtc tcaaaagcac atagatcccc agttattttt  10740

ctgtattgtg gttctcatat acacgtacct ccatagctca gtatatgttt ctgtactata  10800

cacctgttcc tgagggagtg atagggttct cgtgtcatgg ggtccacatt tttgtatgca  10860

aacctcctaa cacctgggtt ttacaggtaa agggaagctg aggactgatt ctagggcagt  10920

ttgcaggcaa tttgcaattc tggaagcaga cagtgaaaat ataattgtgg tcctcccttg  10980

ttctgttctg gaacctagag ggttaacagg cagctcttcc ggtccacccc cctccttcca  11040

gcctgtagct tcttgttgcc gtggagatgg tggccccgcc ccgatgcagc acctgccccc  11100

ccattggctg cagtggtgac tgtggggctg aggggggagc ccaggcctgg gcagccattc  11160

tggagctgga gccggagctt ggcatccccc cacttacatt ctcttccagc ccctcggccc  11220

ctctaaattc ccttgcagcc gagcctcagc ttcctttttc agcgcttgcc atccctctag  11280

gctcttggca gactgagctg catccgcatt cacctcccct cctcctcctt tccctatcct  11340

tacttgggag tcccgagaac ccccactgtc catccttcct gctccctgcc cattcccctg  11400

cattctttgc ttttcccctc cccccaccaa ccttctgagc ccctgccact gcagtgcacg  11460

tggaaccggc tccttctccc ttccccccac ctgccccttc cttggatttt ctgtccccag  11520

cttctccccc tgctactctt cacaggtctc ttccaagacc tccccctcca gtccagggag  11580

ggggtcatgg gaggcagccc tggccctcca gacagacagg ggttccagga ggtggggggc  11640

aggtggaaga tgtgcccacc agggggaaga ggaaagcctg cctatgggca atgaccttta  11700

acccatcttt ccccccagct agccccttct ggggtgggtg ggcaccaggg acctagcctc  11760

cctggatctt tggtgtcctt cattactggg gttttactga ccctctcagc catgctcccc  11820

tgctgactgc cagccccagt catgggccta aggcctccca ccccatcccc ctcagggggc  11880

tcctgctcag gttccttgcc ccctccttcc cgctgccagc ctctccgccg tcgctgctct  11940

tcctgctgct ttccgggggg taggtgaggc cggagctgag gggcagaggg aggtgggggc  12000

atgcactggg gtcaggggtg ggaacctggg ttaacagctt cccttctggc cccctcccca  12060

acttcccttc tggccatttc ctcccctcca gaataccact tgggtcgctc gaggaggaag  12120

agtgtcccag gggggaagca gtacagcatg gagggtgccc ctgctgcgcc cttccggccc  12180

tcggtgagtg gtgcctacca gatgtggctc agttgggccc cctcccctcc agccccaact  12240

ggggccctag gagtctgaga aagagggcag gagggggaga gagggagtga gagtgagaaa  12300

aagagtgtgt gtctgtgtgt gtctccccac ctctttggtt tcccccttct tggctctgcc  12360

cccctgcttc tgagaccagc cctcccacct tctccaagct gtgtgtgtgt gtatatgtgt  12420

gtgtgtgtgt gcttgcactg tacccgtggg agcaaggaag acaaactggt attagggttc  12480

ctatccccct ttcctcgcct ctggagactt cccttttccc catcccactt tcatccaggg  12540

gctctctacc agctgaggga tgagtaggta gaactgaccc tgccccaacc caccccatcc  12600

ccatttcccc cccagcaagg cttcctgagc cgacggctaa aaagctccat caaacgaacg  12660

aagtcacaac ccaaacttga ccggaccagc agctttcgcc agatcctgcc tcgcttccga  12720

agtgctgacc atgaccggta caggggctgg agcatgtggg atgagattga tgtaatgtag  12780

ggtctcctgt gtgagatgca gagggagggg gttatctgtg tgcaaaggtt gaaggattca  12840

actcaagttg gttgggggat gtcatggcac aggggacaga acagaaaaga actagaatag  12900

ggatctgtga gcagcaggag aggggtaggg tggcagagag aagacagaca gacaggctgg  12960

aaagggaatg aaggtgaagc caaggaggga ctcctcaggg actcctcagg ccaagaagga  13020

tgggctctag cccaggatca aaggagctgt acaggaggag agtgaccctg gaggaatgtt  13080

taaggaatgc agggaagggg ttggtaggtg agtgagcaat aggctgtagg tggaagggtg  13140

tcagggaagg tcaggaaata caggggcagc aggttggagt ggggctgggg gtggctgaat  13200

gaatggatga tggctagggc tcaaggacct catcagtgag ggaagagaca gtatagagca  13260

tggcagagaa ggggaggctg ggacaggtgt gcagggtgac agaatgggaa gcaacccatg  13320

gactgaggca tgaagaagca gccagcggag aagtccagaa ggcactgtcc ctgagaccag  13380

gctgaaggag acctccactg tttgcctttg ttgcctgcca tttggggttc ctctctgggt  13440

ttccccctca cccagtcact ccccagggag aaccatgccc tccctttccc ccatgtctgg  13500

ccacccccag gattgggcag gtagggaggt tgggataaag tgagtcacac ctttccctgc  13560

ccccctccca tgttgccaga gctggatttg gggccggcag ggggtgaggg catggtattc  13620

ctggccgcgg gggcgggggg gggggtccgg gggccggggg agcgtcgcgc tgacggcagc  13680

cagagcctgc gatgacgggg ctgctataaa taacttcttg gaggctccca cacccaagct  13740

cccctcccgc tttcccactg ctctctactc ttcatcccct gcccatctcc ataccgcttt  13800

tgtattgcta tcctacccct cattattcca tgcccctagc cccctttatc ttctgccctc  13860

ctgcagtgat ttttttgcat tccatcccct cttagccctc acctcggttc tcccggccat  13920

ctctccagtt ggccttcctc ctcttctcct gtcctctgtc ttgctgcaca tacctttgtc  13980

tccccctttc ttcttcttgc cctacctcct cttcttccct agtccgtgta ttctgtcttt  14040

tatcctcttt gagctctttt ctgcccacag ctttctccta tttcttatgc ttttccctca  14100

ctctttcccc tgcttctgct aaaacttgtc ctcttatgct gtgttcattc attctttgaa  14160

tcattaaatg tttatcaggc actagccgtg tgccaggccc aggctagaca tatctcttct  14220

ctgtgccttc acttctttac ttccactttt tcctttatac tgaggctctg gtttctgggg  14280

ttacctggag gtactaccta gaagtgcccc aggcccactt tgttctctcc tttttttttt  14340

ttcttttctg ccatggtcca tttctgggtt gagatatttc tagatgtccc cagtcctcgc  14400

aatcccttag gtgtgagatg gtgggagttt cttttttttc cttttttttt ttttaaatag  14460

aaatagggtc tcactgtgtt gcccagactg gtcttgaact cctgggctca agtgaccctc  14520

ccacctcggc ctttgaaatg ttgggattac aggtgtgagc caccaggccc aggtggagca  14580

ggggagttcc ttaaaggatt ctgatttttc tcacatccct cacgtccttc ctgataggca  14640

gggtttcttt ctgtgtctgt ttgggaaggg tgttcagggg gccttctctc caagtctcca  14700

tcctggaaca gactgatgat gcagggtacc tatgtgtcta agaagagtag gggggccggg  14760

cgcggtggct catgcctgta atcccagcac tttgggaggc tgaatcactt gaggtcagga  14820

gtttgagacc agcctgacca acagggtgaa accccgtctc agctaaaaat acaaaaaaaa  14880

aaaagaaaaa aaaattagct gggtgtgctg aggcaggaga gacgcttgag cccaggaggc  14940

agaagttgca gcaagccgag atcacaccac tgtactccag cctgggcgac agagcaagac  15000

tgtctcaaaa aaaaaaaaaa aaaaaaaaaa ggaagagtgg gaagccctga tcccttcctc  15060

tcctgaacct cctgcctgcc agggcccggc tgatgcaaag ctttaaggag tcacactctc  15120

atgagtcctt gctgagtcct agcagtgcag ctgaggcatt ggagctcaac ttggatgaag  15180

attccattat caagccagtg cacagctcca tcctgggcca ggagttctgt tttgaggtac  15240

tgggtctggt gggctgggga gggccaaagg acaggggtga tggaaggtgg ggggcagaga  15300

ggtctagaga aagtggcaca ggtggggaca tcaaggaaac agaaacttct gggactggag  15360

gaaagggtag gccagggagg aagagaaggt agcagagtct cctcccctct gtagcccttt  15420

ccctcaactc cacactcctt tctaggtaac aacttcatca ggaacaaaat gctttgcctg  15480

tcggtctgcg gccgaaagag acaaatggat tgagaatctg cagcgggcag taaagcccaa  15540

caaggtattg gggaataaag gggacacaac ctgtgcaggg caaaggttgc accaacacgg  15600

gaagctgggg gcctagggag gaaagtgagt taaaggagga gaggcttggg gaaggagagg  15660

attgaggtac agtgtatctg gacaagcagg gggagacccc cattattctg agtcccccat  15720

ttcttttcgc tttctgtact gctaccctgc cttacgatct ctttccctgc catagaagtc  15780

atagacttac agagttgatg gggctctgga aattctttag tctagcttcc ctgcaggcag  15840

gaatgcttca ctaatacccc gcaggacaca tcaaatacac ttagccaagt ttctgtacct  15900

tggtttcctc tctaagacag agggaactgg tggcaatggg ttggattaaa tgatctctaa  15960

ggtccctttg gcacataaat tctatgagtc tgttcttccc aaaacttcat gcttccagtt  16020

ctgtcagcta ttctctgtat cccagtttct agcaagctta cagtcctagt cacactcctc  16080

tggggggaac tcttgtgtct tgatgtcctt aaagaactca acccaagatg ctgacatgat  16140

ctgacctatg cagagtacaa acaccatgtt ccctttcaac acactgcaat atcacctgag  16200

ccttaccatt agcttgtgct caattgtatc cccccaggcc cttactgatt cttttttttt  16260

tttttttgag acagagtctc actctgtcac ccaggctgga gtgcagtggc gtgatcttgg  16320

ctcactgcaa cctccgcctc ctgggtttaa gcaattcctg tgcctcagcc tccccagtag  16380

ctgggattac aggcatgcac caccacaccc gactaatttt tgtattttta gtagagacga  16440

ggtttcacca tgttggccag gctagtctca aactcctgac ctcaggttgt ctgcctgcct  16500

cagcctccca aagtgctagg attacaggca tgagccacca catctggcca agctttaccc  16560

attctatatg caattctttt ttcacaattt ctgatagtct ctgcaggact ttccagttcc  16620

cttcaaattc tacattaata tttttggctt gttattccag cttttgaaat ctttccaata  16680

ctgtttgtgt tgtctagtgt atgtctacgc ttctacagta gcttcctggg gctgctataa  16740

caaactgcta caaactgggt cacgtaaaac aacagaaatt tattctctca cagttcagga  16800

ggctggaagt ccaaaagcaa ggtatcagca gggccacgct ctctttgatg ctgtagcagg  16860

gaatccttcc ttgcctcttc ctagcttccg gaggttgcca gcagtccttg gcattcctgg  16920

gcttataact gcatccgtct aatttctgcc tccatcttca tgtagctggc ttccttctgt  16980

gtgtctctgt atcctgtatc tctgtgtctc caaatctccc tctccatata aagacaccag  17040

tttttataag gtgggttaag ggtccactct aattcagtat ggcctctttt ttttgagatg  17100

gaatatcgct cttgtttccc aggcttggag tgcaatggca tgagctcagc tcactgcaac  17160

ctccgccttc caggttcaag tgattctcct gcctcagcct cctgagtagc tgggattaca  17220

ggcacgtgcc actatgccca gctaatttgt ttttgtattt ttattagaga cggggtttca  17280

ctatgttggc caggctggct cgaactcctg acctcaggca atccacccac ctcggcctcc  17340

caaagtgctg ggattacagg aatgagatac catggctggc ctcttcttag tttgattaca  17400

tttgcaggga tcctgtttcc aaataagatc acattcacag gttcagggta gacatgagtt  17460

ttggtgggat actattcaac ccagtacacc gtctcacctt atgattgctg tctgtatccc  17520

actttcttac tgtctctcct cttttggtgt ctctctgtcc cttccccctt taacatcatg  17580

cccaccccac catgccagga caacagccgc cgggtagaca atgtgctaaa gctgtggatc  17640

atagaggccc gggagctgcc ccccaagaag cggtactact gtgagctctg cctggatgac  17700

atgctgtatg cacgcaccac ctccaagccc cgctctgcct ctggggacac cgtcttctgg  17760

ggcgagcact tcgagtttaa caacctgccg gctgtccgtg ccctgcggct gcatctgtac  17820

cgtgactcag acaaaaagcg caagaaggac aaggcaggct atgtcggcct ggtgactgtg  17880

ccagtggcca ccctggctgg gcgccacttc acagagcagt ggtaccctgt aaccctgcca  17940

acaggcagtg ggggatctgg gggcatgggt tcgggagggg gagggggctc ggggggtggc  18000

tcagggggca agggcaaagg aggttgcccg gctgtgcggc tgaaagcacg ttaccagaca  18060

atgagcatct tgcccatgga gctatataaa gagtttgcag agtatgtcac caaccattat  18120

cggatgctgt gtgcagtctt ggagcccgcc ctgaatgtca aaggcaagga ggaggttgcc  18180

agtgcactag ttcacatcct gcagagtaca ggcaaggcca aggtgagtgt tgtgccctca  18240

gggaaaggtg acttgggaat gggcacttgc ttgggggtta gtgaggacag ggcaaattca  18300

cgagattggg ttgtgcagag gctgacactt ggattttcct gggcctcagg acttcctttc  18360

agacatggcc atgtctgagg tagaccggtt catggaacgg gagcacctca tattccgcga  18420

gaacacgctt gccactaaag ccatagaaga gtatatgaga ctgattggtc agaaatacct  18480

caaggatgcc attggtatgg cccacactca ggccctcttc ttcccaaacc tgccagatgt  18540

ccaccccaga ccccaagtcc acccttccac agcttgatac ttcctaaccc agagtcctag  18600

gactccagcc tccaacacct gattctgaaa tttccccaac cctggccacc cccttccctg  18660

cccttggaaa gtgtgaccac accctcttgt gcccccaccc cccaggagaa ttcatccgtg  18720

ctctgtatga atctgaggaa aactgcgagg tagaccctat caagtgcaca gcatccagtt  18780

tggcagagca ccaggccaac ctgcgaatgt gctgtgagtt ggccctgtgc aaggtggtca  18840

actcccactg gtgagactgg gaacgctggg ctggggggcc agggtcgggg gaattatgtg  18900

ttcatctgtt catctatctg tccatcctca aagaggactg agcaccattt atgggcaaag  18960

cattgttcta ggcgctatag agcaaacagg tgaaagaggc ctggtccctg ccctcagagg  19020

gcctccacca gaatggggac aaattagaag aaaaaaaaaa aaagccacag agccataatg  19080

gtgtgtaagt gctgagtaag ggtcccccca acctctgtgt gacataaggt cagagagaag  19140

gcagagcttt gagataagtg gggaagaggt gcccccttgg gtaggctttg aagactggtt  19200

taggttctga tatatggaca tagttggcaa gaaagacatt tcagaagaag gctgtgagaa  19260

aggcacatgt gtgatggtga aaaggcccag gagttttcag gggacattaa agtaggttag  19320

tagcaattac atcaggttta gtggagcatg tgcctcataa tggggagtgg cgggagagat  19380

gtctgggcag gaagattagc tttagaaact ggaaggcctc aaggagtctg aggtcattgg  19440

taggccttgg gatgccatta aaggtgtcag aaatattgtg atttagaaga ttaatccata  19500

ggctgggcac ggtggctcac acctgtaata ccagcacttt gggaggctga ggcgggcaga  19560

ccacctgagg tcaggagttt gagaccaggc tgaccaacat ggagaaaccc tgtctctact  19620

aaaaatacaa aattagccag atgtggtggc acatgcctgt aatcccagct attcgggagg  19680

ctaaggcagg agaatcactt gaatctggga ggtggaggtt gtagtgagcc gagatcacac  19740

gattgcactc tagcctgggc aacaagagtg aaactccatc tcaaaaaaaa aaaattaatc  19800

cataagtaga gtgtatgtag tagagtagag ggatgtatgt tgggggatga ctggaataga  19860

gccagctggg ggctcggagg catgaaagtc agatcctgaa tcagaacagt gacagaagtt  19920

aggaaggagc tactggaagg accctctcgg gaaaggatca gtaggaattg tcagcttatt  19980

ggaaaggagg gagcatgtct gtggggagtc acggatgact caagaggcca tgaggctggt  20040

ggttgggaga ccggtggcct cattgacaac caggaaagtc aggaggagga gccagttgga  20100

ggtgtggggg cgatggtgag ctctgcttta caccagccga gtttaaggtg tcagtgggac  20160

attgaagtgg aactgggagg tgcggggagt gagctctgag ccattccagg gactggggat  20220

catgcctggg gcacctccat ccccatttcc ctggaatcca gaagagttgg ggggtccgag  20280

ctccctgtac ctcaagtgac cctccatctc tctcccatct ctgtctctcc ctggtgtctg  20340

tttttcttct cctcctctcc ttgtctctct cccacacccc tccatctctc tcccacgtgt  20400

ctctcccctc accttctctc cccctccatt tctctctccc taatctgtct gttccctctg  20460

ccatggcccc cttcttcaag cagcctccca tcttgctcct gcggtccctc cttccctgtc  20520

tctctcaccc ctgtttccac accctcacct cctaccaccc ccctcagcat gttccctgga  20580

agctgagggt ctctggggct cagtcccggt ctctctcttt ctctctctct ctctctgtct  20640

ccccgaccct tccccccagc gtgttcccga gggagctgaa ggaggtgttt gcttcgtggc  20700

ggctgcgctg cgcagagcga ggccgggagg acatcgcaga caggcttatc agcgcctcac  20760

tcttcctgcg cttcctctgc ccagcgatta tgtcgcccag tctctttggg cttatgcagg  20820

agtacccaga tgagcagacc tcacgaaccc tcaccctcat tgccaaggtc atccagaacc  20880

tggccaactt ttccaagtga gggaagcttc aggagtgggc agggcaggga gtggcagggc  20940

agggagtggc agggctgggg gtcggcaaga agggtctcct gagtccccag agatcctgag  21000

atggggaggc tatgatacct tgtgtgtgtg tgtatgtgtg tgtatgtgtg tgtgtgtgtg  21060

tgtgtgtgtg tatgtgacct ttatcttctg cattcttggc taggtttacc tcaaaggagg  21120

actttctggg cttcatgaat gagtttctgg agctggaatg gggttccatg cagcagtttt  21180

tgtatgagat ctccaatctg gacacgctaa ccaacagcag tagctttgag ggttacatcg  21240

acttgggccg agagctctcc acactgcatg ccctactctg ggaggtgctg ccccagctca  21300

gcaaggtcag cagatcccct ctttgcccta tccccagatg gctccagagg ttcctggagc  21360

ctgagaaact accctttgaa gatttttttt ctccccttgt ttctcgaggt gtcaccacta  21420

ctatcccaac tcaggccccc tccacctgca ccctcagagg ccctcttaga gctgggcact  21480

gagcccccag gtaacagcct cacccttcca ggaagccctc ctgaagctgg gtccactgcc  21540

ccggctcctc aacgacatca gcacagctct gaggaacccc aacatccaaa ggcagccaag  21600

ccgccagagt gagcggcccc ggcctcagcc tgtggtactg cgggggccat cggctgagat  21660

gcagggctac atgatgcggg acctcaacag gtgagcaccc tgggacagcc aggcctgtgc  21720

cctaggagcc cttctcctat tctagatact cctcactggg ccccacatgc atctctctag  21780

ggcttgaaag aagggaggaa aaagcaccaa gttctcaggg gagacgataa ggagacaggt  21840

acagtcagtg gtaggctgag agccctttac agcctgaggg agtgagagat ttggagctct  21900

aggaataggg ctgaggctcc accaactcac ggcttagttg taagcctaga gcatccctgc  21960

tgcaagctct gatttgctgt ccctctgcct gcccatgcta gtccccaggc tgaggttcag  22020

ccagcatgtc atgtcagcca tgtgtcaaaa tgttcaaaca tctcagtaat agctagtgaa  22080

taagcacttc ccccagcccc cgaccacaac cccacagacc tccccatgat ccagcactta  22140

gagcagtgac agcagaagcc tagcagggcc tgcagcctgc tccagagtcc cagcctccat  22200

tctgataggt ggtgcccgtg cttcatttgc tgctcattat tttgatgatg gccctgcttt  22260

ttcctctgcc cgtgtcttcc tccatgacac catacccatc ccaccattcc cgcctctcct  22320

ttcatttgtc cacatctctc tccttctctg tctgtgctcg cccctctttc catctctctc  22380

cagctccatc gaccttcagt ccttcatggc tcgaggcctc aacaggtgag gggctctccc  22440

ctcccccgcc ctcctctcct ctcctgtctg ttccctctcc cactccactg gccttcgccc  22500

tactcctctc ctctcctcct ccatggacct catctcctcc atatgtgccc agccctgccc  22560

ccatcccttc tcttgctgcc cccatctccc ctcctctagg cctcaccccc ttcccggagg  22620

ggccctgtcc tttcccttta ctcacctgtc ccctcccatc ctccctgcct gccctcttca  22680

gggctgccac cgctagctct cagcccttcc ctctgggtcc cacttttcac cccaaggcct  22740

gtgccagacc acagcaaggt tcaattgcta ggagccctga ccttaccttc tgcttgtgtg  22800

cccccttccc ttctgacagc tctatggaca tggctcgcct cccctcccca accaaggaaa  22860

agccaccccc accaccgcct ggtggtggta aagacctgtt ctatgtaagc cgtccacccc  22920

tggcccgttc ctcaccagca tactgcacga gcagctcgga catcacagag ccagagcaga  22980

agatgctgag tgtcaacaag agtgtgtcca tgctggactt acagggtgat gggcctggtg  23040

gccgcctcaa cagcagcagt gtttcgaacc tggcggccgt aggggacctg ctgcactcaa  23100

gccaggcctc gctgacagca gccttggggc tacggcctgc gcctgccgga cgcctctccc  23160

aggggagtgg ctcatccatc acggcggctg gcatgcgcct cagccagatg ggtgtcacca  23220

cagacggtgt ccctgcccag caactgcgaa tccccctctc cttccagaac cctctcttcc  23280

acatggctgc tgatgggcca ggtcccccag gcggccatgg agggggcggt ggccatggcc  23340

caccttcctc ccatcaccac caccaccacc atcaccacca ccgaggtgga gagccccctg  23400

gggacacctt tgccccattc catggctata gcaagagtga ggacctctct tccggggtcc  23460

ccaagccccc tgctgcctcc atccttcata gccacagcta cagtgatgag tttggaccct  23520

ctggcactga cttcacccgt cggcagcttt cactccagga caacctgcag cacatgctgt  23580

cccctcccca gatcaccatt ggtccccaga ggccagcccc ctcagggcct ggaggtggga  23640

gcggtggggg cagcggtggg ggtggcgggg gccagccgcc tccattgcag aggggcaagt  23700

ctcagcagtt gacagtcagc gcagcccaga aaccccggcc atccagcggg aatctattgc  23760

agtccccaga gccaagttat ggccccgccc gtccacggca acagagcctc agcaaggagg  23820

gcagcattgg gggcagcggg ggcagcggtg gcggaggggg tggggggctg aagccctcca  23880

tcaccaagca ggtaggtgaa ggcaggagga aggcgggctg ggtcacaaca gggagggaag  23940

aaggagatgg ggggtggggt tgaaacagag tctgtggcct gaagttacaa tcttcttgcc  24000

tccttttggc cattaaacaa atgtgtatag agggcctgct atgtgccatg tgctatgcca  24060

ggcactaagg atacggcact gaaccctctt agcactctca ttccagaggg gattaatcca  24120

taagtagaat gggggtgact ggaatagggc cagctggggg cttggaggca tgaagatcag  24180

atcctgaatc agaacaacag gagaaattct ctggcattca actcacatct ctggcattca  24240

gaggtgataa aggctacagc agggcaatag gactgggact gtcgtctcct ttggctgtgc  24300

tgttgccctc taaatgtacc ctgctttttc ccaccttttc tttctctgtt cgccctcact  24360

gtgccttgtc ccagcattct cagacaccat ccacattgaa ccccacaatg ccagcctctg  24420

agcggacagt ggcctgggtc tccaacatgc ctcacctgtc ggctgacatc gagagtgccc  24480

acatcgagcg ggaagagtac aagctcaagg agtactcaaa atcgatggat gagagccggc  24540

tggatagggt acgatgggct ctaccagctc caagccccag tgtttccttt tacccacagg  24600

ggagatctct agtcacttcc aagggaaacc tccagggtca gttatggtgg taagaaaagg  24660

caaagacctg atcacctctt gagaagcctt ccgtccatct ggggagacca gatacacaca  24720

gttgttaaaa gtcactttca actctatttt gtaggttata tatatcatag actatctggg  24780

gatcatctat tttaggctta cctccatgtt cttccccagg aggaacataa gccctggctc  24840

ctgtgactgc ttaggaaagg aaatgttact ttactggcag taggagctaa taaattggat  24900

ggggatggag ggggttgcag ctatattaca agtgatgtct ggcctaccca gtcactgtcc  24960

catgggcata agtgacagtc agtgggcagg gaatgcatgt ggtaaagtag tatgtatcag  25020

tcatgtgtga aaagaccatc cagaccctca cttggtggag gctgagggca aagggcacca  25080

agagctctgg ggctaacaca gataacttag cagaaagtta cttgaggaag ctgttgttcc  25140

tagggcctga ggaagagggc ggctgcagga ttaggtcata tataaagaac atatgatcct  25200

aacacgggga agtggtcttt gagcatagga aatgttggga ctgactcaga tgggcttgac  25260

cagcaaattt aatgagaatt aaaccctaat attagcccca aggcagccac cgtaggaagt  25320

taattcacat ctctcctctg catgtagaag ggttggtgat atatgtatgt atcctcttca  25380

gagaatgagg aaatagtctt ttgaatcatt tttttttctg tgcttcagat gaggaaacct  25440

tgttgagaaa ggctgtagac tagcactatc caatataact ttctgcagtg atgaaatgtt  25500

ctgtaatctg tagtgttcac atgtgtctag ttgtgattca ggaactgaat ttttagatct  25560

atttaatttt aattttgtaa tttttttgag acagggtctt gctctgtcac ccaggctgga  25620

gtgcagtggt gcaaacatgg ctcgaggcaa cctccgcctc ctgggctcaa gacatcctcc  25680

cacctcagcc ccctgagtag ctaggactac agggtcgtgc taccatgcct ggctagtttt  25740

ttttcttttc tttttttttt tttttttttt ttgtagagac ggggttttgc catgttgccc  25800

aggctggtct agaacttgtg agctcaagtg atctacctgc ctcagccttc caaagtgctg  25860

ggattacagg tgttgagcca ctgtgcctgg cctaaatttt aaatagctac atgtgggctg  25920

gtggctacca tattagacag cacagctgta gactctagag ccaatagggc agataaaatg  25980

actcttctga gctcttccag ctctggaatt cctagattct cagcctagaa ttcacttgta  26040

gacctcctat ccttggcacc ttgacagagc caaggagagg gtcacatgga ggacagcacc  26100

tgcctttccc ccgtcaattg ccttttcttc ctatgtctcc agcatgtgtt ctggggcctg  26160

gcttagggct gaagagtcac cctattttta atttctgagc acagttactc aaggtgtgtt  26220

tgtgagtgta ggtttctgtg tgggtcttca tgaggggcca tacatagacc tcagggtgtg  26280

ggagtctgtg accttgctcc attttgaggg aacctcagca ccatggcagg gtcttctcaa  26340

aagcaggtgt gtggatatga tccacaggca gggaaggggt tggggaaggc agctggatgt  26400

ccctcaacat gcagtggctg tgcttggcag acagggatgg aggctgggtg gtgggcttgg  26460

ggtggggcgc ccctcatagt gcggggtcgt gtgcccggcg ggcaggtgaa ggagtacgag  26520

gaggagattc actcactgaa agagcggctg cacatgtcca accggaagct ggaagagtat  26580

gagcggaggc tgctgtccca ggaagaacaa accagcaaaa tcctgatgca gtatcaggcc  26640

cgactggagc agagtgagaa gaggctaagg cagcagcagg cagagaagga ttcccagatc  26700

aagagcatca ttggcaggtg aggggcggcc tggggagggg gttgtgaggg agagcctgag  26760

gctggagaga gcaagtgggt gagctactcc gctgactccc atccccaaac tcaggagccc  26820

accaggagag cccaccactc tcctccccag gaagccaccc actcactcat caccagatgg  26880

agagaaaccc caacctgctt agtgcattaa atatctcttt accaaaccct gacctctctt  26940

ctgatagagt agcttcggaa gcccttggaa aatgtacctg ttcctgtcca accatcactg  27000

catttgcatt taccctaggc cagagctccc cactagttat tctcaactta acctgtgatg  27060

ttcactccaa acctaagcag ggctccctag ccagagtagg ccctgccctt cctgggtgga  27120

ccctccctct ctagccttgg aaaggtgttc tgttagaaag ggtcttttag cctgtgtatg  27180

ttttcagctg ctccagcaag tcctgggctc caaagagggt atcctcagca aagaggtcaa  27240

ttatcttcag agtggtgggg tcggggtggg ggggaccctg ggcgcactcc aaccagagcc  27300

acctccattt tgatccattc taaatgtatt ttatgtaaga tttaattaga agaaaagggc  27360

ttcttgaaat attttttgaa aaccactgct ctaattgata tcctttatga taaatcacct  27420

cgaggatctt cacagtgagg tgacatgggg gatgcagaag ccaggtcctc agccatggaa  27480

ggtctgggga aggggcactg ctgtcctgat tgggacgatg gaggcctgga ggtgtctgga  27540

tggtagaagt ctttgaggca cagaaagctg ccttagcagg gaggtgtaag ggttcctggg  27600

aggaaggtgg agagcatgat cctgaggaac agggagtctt gcatcacggc aatggaggga  27660

ctctgattct aagggataag gatgcctgag gtttttccag agagctatgg ggttccatgg  27720

gcaggctctg agcctgtgcc cgccactaac cccactgaag cccgtccctt caggctgatg  27780

ctggtggagg aggagctgcg ccgggaccac cccgccatgg ctgagccgct gccagaaccc  27840

aagaagaggc tgctcgacgc tcaggtggaa attacaatgt catttatctt ctccgtgtcc  27900

catccccatc catcccactg tctttcgtgc actcactaca ccagccacct agccccatca  27960

ccatctgtct ctcatagtct gctgtttgtc cactggctgc tcctggcagc cccctagtga  28020

ccccatcttc atcccatcgt ctgtgccttt gtcactcctg gcagcgtcag cccaactcct  28080

gtgccttccc atccagtctt cccactcctc tctgcatctc aggaccttct ctaccagaac  28140

cttggtcttt ctgcccctag accccaccta gttccaagaa cccctgcccc ttctttgctc  28200

actcctattc aagccacgtt gttcagcttc ctctgcgctc ttgggccaga gggctagaag  28260

ctgccgtttt ctggaataga gcacagggca gtatgatctg tagtttctcc aggccctggc  28320

cggtaccctg aaaacttggg gacccatcac ctctgttctc ttggctccct aattttcctg  28380

tctccttggc agctcctgca tagcttcctc ttcctgactc ttcagatctt gaaggccttc  28440

catcctgtaa cctccctttg ccctcagtat ttaagtccag cctccctctg gcctccctcc  28500

cactctggcc ctcagacctt cccagctgcc tgctgcccag cctctcttct cacaagccag  28560

cttctaggac ctcccttctg cacccttacc ccttgctttc ccaaaattct gctcattttc  28620

ctacccatac tcctctttgc tctgactgct aggctccccc cgcctgccat ccccccacca  28680

aggctcctga ccccatgacc ccactctctc ccactgcagc tcctcatcag gtaattctcc  28740

tggttccgct ttggccacgg gcggaggaca cagggggagg tgactccgga ccactgcagg  28800

ttggtcgtga agcccactcc ctccaacacc tccggagcct ctcccctctc actgctgccc  28860

tccacaccca gagaacctcc acagactcca gccctccgac acctgcacag atccatctcc  28920

caagacacca cccaaagaga gcatttgctg ctgcttccca gaactgtcca acaatacctt  28980

agcaacacca agagttgggc cctagatggg cccagcacat tcacaggtca cacccacttc  29040

cctgcaaaac ccaccccctc ccagcctcct cctgactcta agccctcctc ttcctctacc  29100

tctccagtgt atgtctgtca ccccccattt caccagagcg tccttagggg ctgggggtgg  29160

gtttgttaat ggggtggagg caatgatggg ttggaggatc ttggctatag gggctgtgct  29220

gactgcagca ggtaggttgg gtttccctct tccttcccta atcttggttc tctaccctcc  29280

tttccactcc tcacctgatt ctctctcttc ctcctcctta tatctgtgag gcagaaggca  29340

tctgaagctc atattagccc ccattgggtg ggaattagga gtgggtagtt aactcaggga  29400

gacttgagat accctggaaa aaatgctatt gagatgtcct gacattaggc agggtggatg  29460

gaacaagaag gagcaagaaa ggaacctcag gcagatgtta ggacatggac ttgatcatgt  29520

ggcctgggag tttagaaatg gggagagaca tcctcctaga tcagatcgtg ggctcagtag  29580

gcatgttgat tcccagggag aggtgccagg aacagcatgg taaagaatgt actcttcaca  29640

gctcacatcc ccaggttgct gatgccactc actccccctc tcctgccatc gagtggcctt  29700

gccggacaca tcaccctacc taaaaagcca gtaaatgaga acctgtcagc tatagccatc  29760

atttctgaga tgcgattttc tttgggattg agctgcagtg ggcagtggct ccttacactg  29820

taattttaat tctctgcctg cccagcctct ctgtcaaagt agctggtgat ctataaagat  29880

gctaaaaggc accaggggac tttgccattt aaaggactcc tgcagtgaat tcttttgtaa  29940

aatgaataat ggcaccctaa tttatccact ttctaaattt gggtccatgg gggtgtccag  30000

ggcatgctta tgtgctgtca ccagcagaca aacagaggga atggaatctg ggggttcctt  30060

ccctgctctc ccgccatact caggataccc taccataagt gatttcctct cactgacttg  30120

cagaaaatgt gtgagatacc cagcaagcta agaaggcagt tttgctgggt atctcatacc  30180

caaggctggg gtttgggtga tctgagaggt tagctccttg atcctaggat ggaagggaga  30240

gcttatatag aagcttttac ttggaaggtt ttgtatccta aggtcagaca tagctatatt  30300

accaagccta aatgccatgt ggcccaggaa ataatttgga catttgttct aaaccacttg  30360

tggtaggtat tggtctctct gcaactcagc cattaattag aaattagttt tgagcctgaa  30420

ttttaaaaag ccaagtgttg cccccagccc acacacacac acacggacat gtacagtaca  30480

aaccccagat aattacaaca gccaaagaga gaaggaagtg aatttcccaa ccagaagcgt  30540

agggaaattc agatggcttt cttttctccc agcagaggaa cagaaggcgg agctaagggc  30600

aggaaccagg agttggtcaa ggagctatag gaggtgatga gagtagaacc aggggtagga  30660

gctggtctgg tacccctcac cctctaattg ggagcccagg gagaaggact gaaaagaaga  30720

tgggagtgga aaagaataaa gccagtttct gcttcccagg gatgcagaga ttggggcatg  30780

ctgtgtctgc agaagctcct agtcatttcc gccataattg tgagagagag gggcagccct  30840

cccacaagat ttttcccttc ccatatcact tccctgaatc cccttccttt ccccccagta  30900

cagttaaacc tctctctaat ttggaatgtt atatttgaga agatggccac tgtgaataag  30960

tgacaaacgg aatgacagtg tctatttaat gaaatgcatg tcttcaaaat atatacagaa  31020

ctcgatgaac aaggcttttt ccactcctca gggagcatgc attaatgaat agataggatt  31080

caaaagtctg ttttctggta tgggttaaat atcccctcct acagacatat ttccaccact  31140

aatttgctta gtacaccttt tcttcacaga taaaggaaaa tgcaagctca gtttttcttc  31200

agattatgaa gaaattccaa atccacaggg gtttggatta atgaggtttt gctgtactgc  31260

ctccccttat tcctcaacat gaagttccca cctcggattg gggatgggtg ggagggggtt  31320

tcaagaggag gagggtggga tgggcaagga atatacacag gtgaagccag agaagggtta  31380

ggttgggggt gcggtgggaa cttgctgttt tgatctggtt tcctggtgtg acactctggg  31440

ttaaaggctt gaaggcccct gttaggagtc taggggtgag attctcttct ctctgatccc  31500

agaggacgtt aacttctact gcaggtgaga aacaaaatag gaggatggtg gggactgtcc  31560

tgggaggagg gggtggtcca tggcttgtgg tgtgggctgg ctatagggga ggccactgct  31620

aggggactgg catccaggcc cccttgaagc gtctcaataa gtccgcgctc tcctttttgg  31680

tgtcttgcag gagaggcagc ttcccccctt gggtccaaca aacccgcgtg tgacgctggc  31740

cccaccgtgg aatggcctgg cccccccagc cccaccaccc ccaccccggc tgcagattac  31800

ggagaacggc gagttccgaa acaccgcaga ccactagccc acccagcatc agagaccttc  31860

tcttcctttc ctgtgcaccc caccctgtaa cagcaccaac caccaggatt ggacatcacc  31920

gaggaacagc gggattgcct ccccgaatgc ctccctggga ggcacactga ttgcccaccc  31980

ccaccactgc accatttcca ggagggagag tggggaccct cagccgcccc cttttccttc  32040

ccattggggt gctgccctct ctttgacccc cagggaccct tgccccagga caccgcctac  32100

cccgtacaga ccccttcact ccggggtgct atccccatcc tctgcctcat cgttcccctg  32160

agcactgggg gacagaccct cacccccacc ctgggggtgt ggcacctcca aactttcaac  32220

ttcagggtga tttttttagc agtaaccaga gctgacaatc taactcccct ccaccgcccc  32280

attttggcct cccctgcccc ccttgttatg gggaggggac cccgggtgag ggggccctat  32340

taccccttga tttctcagga gcgtctgggg gggctcagca cgcacaaact ccttctcctt  32400

ctaccactct taaatttact ccctccccac ccagaaccca gatggggtgg agggggccac  32460

cggggcaggg agggggcggc aaggggggaa tgggagttgt ctccccttct ccccacacct  32520

gatctgctct cggctggtcc cagagcgggg tgagggggct tatgcccccc cctcccccag  32580

tgtgttgggt ggggtggaat tgaggttagg gtgaggggtc agggtttagg agggtgtgta  32640

tgttgggagg acaggctagt tgatctgtcc tactctgaca cacagtcccc tctgcccctt  32700

ccttctctct tcttggtctc tactcccagg gggagggggg aacttactct aggaaaagcc  32760

atgtctctct cccccagggt ggggggacct gtgttggagg aggggtgttg gggggccccc  32820

ttccatgact ctgtcccctg ggggaggtag gacagggctg ggcttccctc tcatcctccc  32880

cctcccaatc tccttccacc tccctccctc ccgccagctc cacgattttt cggtgtttct  32940

ctgtacatag ttttctggcg ggatagggga ggtaggatgg atggggtttg gggtgggtag  33000

gccatgggag gggagaagcc cctccttggc accccctctt ccctgactgc tgtcccctac  33060

ccagccttgc ccccttcatc cttttgcgtt tggtattgag actctcctag actctactcc  33120

tctttctttt gtatggacag ttccccttca gtcccatccc cctacacata cacccagccg  33180

gggccaaatt tatacttata taaaagttgt aaatatgtga aattttatcc ctgtgccctt  33240

tccccacctc aggccctacc cctggaccct ccccaacctt ccttctctct tctttggctg  33300

ttgtaattat ctggggtttg tactgtacat atccggggtg tgtgtgtgtg ggctgggggc  33360

aacccttctg tacagagctt cctggccccc tccccccccg cccctctgct tccctcccca  33420

cccaccacct caagggtagg gagttgctct tcctacctgt tttattttgt tttctcgttc  33480

tccctcccca ccccactccc agccttatct atcccccctc actgtcccct tttctccact  33540

cccagcccca tttccttttt ttctggagtg tgtggtgaaa cagaaaaaaa catgtttaat  33600

aaacggagat tgttctttta                                              33620


<210>  8
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ser Arg Ser Arg Ala Ser Ile His Arg Gly Ser Ile Pro Ala Met 
1               5                   10                  15      


Ser Tyr Ala Pro Phe Arg Asp Val Arg Gly Pro Ser Met His Arg Thr 
            20                  25                  30          


Gln Tyr Val His Ser Pro Tyr Asp Arg Pro Gly Trp Asn Pro Arg Phe 
        35                  40                  45              


Cys Ile Ile Ser Gly Asn Gln Leu Leu Met Leu Asp Glu Asp Glu Ile 
    50                  55                  60                  


His Pro Leu Leu Ile Arg Asp Arg Arg Ser Glu Ser Ser Arg Asn Lys 
65                  70                  75                  80  


Leu Leu Arg Arg Thr Val Ser Val Pro Val Glu Gly Arg Pro His Gly 
                85                  90                  95      


Glu His Glu Tyr His Leu Gly Arg Ser Arg Arg Lys Ser Val Pro Gly 
            100                 105                 110         


Gly Lys Gln Tyr Ser Met Glu Gly Ala Pro Ala Ala Pro Phe Arg Pro 
        115                 120                 125             


Ser Gln Gly Phe Leu Ser Arg Arg Leu 
    130                 135         


<210>  9
<211>  578
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ser Arg Ser Arg Ala Ser Ile His Arg Gly Ser Ile Pro Ala Met 
1               5                   10                  15      


Ser Tyr Ala Pro Phe Arg Asp Val Arg Gly Pro Ser Met His Arg Thr 
            20                  25                  30          


Gln Tyr Val His Ser Pro Tyr Asp Arg Pro Gly Trp Asn Pro Arg Phe 
        35                  40                  45              


Cys Ile Ile Ser Gly Asn Gln Leu Leu Met Leu Asp Glu Asp Glu Ile 
    50                  55                  60                  


His Pro Leu Leu Ile Arg Asp Arg Arg Ser Glu Ser Ser Arg Asn Lys 
65                  70                  75                  80  


Leu Leu Arg Arg Thr Val Ser Val Pro Val Glu Gly Arg Pro His Gly 
                85                  90                  95      


Glu His Glu Tyr His Leu Gly Arg Ser Arg Arg Lys Ser Val Pro Gly 
            100                 105                 110         


Gly Lys Gln Tyr Ser Met Glu Gly Ala Pro Ala Ala Pro Phe Arg Pro 
        115                 120                 125             


Ser Gln Gly Phe Leu Ser Arg Arg Leu Lys Ser Ser Ile Lys Arg Thr 
    130                 135                 140                 


Lys Ser Gln Pro Lys Leu Asp Arg Thr Ser Ser Phe Arg Gln Ile Leu 
145                 150                 155                 160 


Pro Arg Phe Arg Ser Ala Asp His Asp Arg Ala Arg Leu Met Gln Ser 
                165                 170                 175     


Phe Lys Glu Ser His Ser His Glu Ser Leu Leu Ser Pro Ser Ser Ala 
            180                 185                 190         


Ala Glu Ala Leu Glu Leu Asn Leu Asp Glu Asp Ser Ile Ile Lys Pro 
        195                 200                 205             


Val His Ser Ser Ile Leu Gly Gln Glu Phe Cys Phe Glu Val Thr Thr 
    210                 215                 220                 


Ser Ser Gly Thr Lys Cys Phe Ala Cys Arg Ser Ala Ala Glu Arg Asp 
225                 230                 235                 240 


Lys Trp Ile Glu Asn Leu Gln Arg Ala Val Lys Pro Asn Lys Asp Asn 
                245                 250                 255     


Ser Arg Arg Val Asp Asn Val Leu Lys Leu Trp Ile Ile Glu Ala Arg 
            260                 265                 270         


Glu Leu Pro Pro Lys Lys Arg Tyr Tyr Cys Glu Leu Cys Leu Asp Asp 
        275                 280                 285             


Met Leu Tyr Ala Arg Thr Thr Ser Lys Pro Arg Ser Ala Ser Gly Asp 
    290                 295                 300                 


Thr Val Phe Trp Gly Glu His Phe Glu Phe Asn Asn Leu Pro Ala Val 
305                 310                 315                 320 


Arg Ala Leu Arg Leu His Leu Tyr Arg Asp Ser Asp Lys Lys Arg Lys 
                325                 330                 335     


Lys Asp Lys Ala Gly Tyr Val Gly Leu Val Thr Val Pro Val Ala Thr 
            340                 345                 350         


Leu Ala Gly Arg His Phe Thr Glu Gln Trp Tyr Pro Val Thr Leu Pro 
        355                 360                 365             


Thr Gly Ser Gly Gly Ser Gly Gly Met Gly Ser Gly Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Ser Gly Gly Lys Gly Lys Gly Gly Cys Pro Ala Val 
385                 390                 395                 400 


Arg Leu Lys Ala Arg Tyr Gln Thr Met Ser Ile Leu Pro Met Glu Leu 
                405                 410                 415     


Tyr Lys Glu Phe Ala Glu Tyr Val Thr Asn His Tyr Arg Met Leu Cys 
            420                 425                 430         


Ala Val Leu Glu Pro Ala Leu Asn Val Lys Gly Lys Glu Glu Val Ala 
        435                 440                 445             


Ser Ala Leu Val His Ile Leu Gln Ser Thr Gly Lys Ala Lys Asp Phe 
    450                 455                 460                 


Leu Ser Asp Met Ala Met Ser Glu Val Asp Arg Phe Met Glu Arg Glu 
465                 470                 475                 480 


His Leu Ile Phe Arg Glu Asn Thr Leu Ala Thr Lys Ala Ile Glu Glu 
                485                 490                 495     


Tyr Met Arg Leu Ile Gly Gln Lys Tyr Leu Lys Asp Ala Ile Gly Glu 
            500                 505                 510         


Phe Ile Arg Ala Leu Tyr Glu Ser Glu Glu Asn Cys Glu Val Asp Pro 
        515                 520                 525             


Ile Lys Cys Thr Ala Ser Ser Leu Ala Glu His Gln Ala Asn Leu Arg 
    530                 535                 540                 


Met Cys Cys Glu Leu Ala Leu Cys Lys Val Val Asn Ser His Cys Val 
545                 550                 555                 560 


Phe Pro Arg Glu Leu Lys Glu Val Phe Ala Ser Trp Arg Leu Arg Cys 
                565                 570                 575     


Ala Glu 
        


<210>  10
<211>  833
<212>  PRT
<213>  Homo sapiens

<400>  10

Ser Arg Ser Arg Ala Ser Ile His Arg Gly Ser Ile Pro Ala Met Ser 
1               5                   10                  15      


Tyr Ala Pro Phe Arg Asp Val Arg Gly Pro Ser Met His Arg Thr Gln 
            20                  25                  30          


Tyr Val His Ser Pro Tyr Asp Arg Pro Gly Trp Asn Pro Arg Phe Cys 
        35                  40                  45              


Ile Ile Ser Gly Asn Gln Leu Leu Met Leu Asp Glu Asp Glu Ile His 
    50                  55                  60                  


Pro Leu Leu Ile Arg Asp Arg Arg Ser Glu Ser Ser Arg Asn Lys Leu 
65                  70                  75                  80  


Leu Arg Arg Thr Val Ser Val Pro Val Glu Gly Arg Pro His Gly Glu 
                85                  90                  95      


His Glu Tyr His Leu Gly Arg Ser Arg Arg Lys Ser Val Pro Gly Gly 
            100                 105                 110         


Lys Gln Tyr Ser Met Glu Gly Ala Pro Ala Ala Pro Phe Arg Pro Ser 
        115                 120                 125             


Gln Gly Phe Leu Ser Arg Arg Leu Lys Ser Ser Ile Lys Arg Thr Lys 
    130                 135                 140                 


Ser Gln Pro Lys Leu Asp Arg Thr Ser Ser Phe Arg Gln Ile Leu Pro 
145                 150                 155                 160 


Arg Phe Arg Ser Ala Asp His Asp Arg Ala Arg Leu Met Gln Ser Phe 
                165                 170                 175     


Lys Glu Ser His Ser His Glu Ser Leu Leu Ser Pro Ser Ser Ala Ala 
            180                 185                 190         


Glu Ala Leu Glu Leu Asn Leu Asp Glu Asp Ser Ile Ile Lys Pro Val 
        195                 200                 205             


His Ser Ser Ile Leu Gly Gln Glu Phe Cys Phe Glu Val Thr Thr Ser 
    210                 215                 220                 


Ser Gly Thr Lys Cys Phe Ala Cys Arg Ser Ala Ala Glu Arg Asp Lys 
225                 230                 235                 240 


Trp Ile Glu Asn Leu Gln Arg Ala Val Lys Pro Asn Lys Asp Asn Ser 
                245                 250                 255     


Arg Arg Val Asp Asn Val Leu Lys Leu Trp Ile Ile Glu Ala Arg Glu 
            260                 265                 270         


Leu Pro Pro Lys Lys Arg Tyr Tyr Cys Glu Leu Cys Leu Asp Asp Met 
        275                 280                 285             


Leu Tyr Ala Arg Thr Thr Ser Lys Pro Arg Ser Ala Ser Gly Asp Thr 
    290                 295                 300                 


Val Phe Trp Gly Glu His Phe Glu Phe Asn Asn Leu Pro Ala Val Arg 
305                 310                 315                 320 


Ala Leu Arg Leu His Leu Tyr Arg Asp Ser Asp Lys Lys Arg Lys Lys 
                325                 330                 335     


Asp Lys Ala Gly Tyr Val Gly Leu Val Thr Val Pro Val Ala Thr Leu 
            340                 345                 350         


Ala Gly Arg His Phe Thr Glu Gln Trp Tyr Pro Val Thr Leu Pro Thr 
        355                 360                 365             


Gly Ser Gly Gly Ser Gly Gly Met Gly Ser Gly Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Lys Gly Lys Gly Gly Cys Pro Ala Val Arg 
385                 390                 395                 400 


Leu Lys Ala Arg Tyr Gln Thr Met Ser Ile Leu Pro Met Glu Leu Tyr 
                405                 410                 415     


Lys Glu Phe Ala Glu Tyr Val Thr Asn His Tyr Arg Met Leu Cys Ala 
            420                 425                 430         


Val Leu Glu Pro Ala Leu Asn Val Lys Gly Lys Glu Glu Val Ala Ser 
        435                 440                 445             


Ala Leu Val His Ile Leu Gln Ser Thr Gly Lys Ala Lys Asp Phe Leu 
    450                 455                 460                 


Ser Asp Met Ala Met Ser Glu Val Asp Arg Phe Met Glu Arg Glu His 
465                 470                 475                 480 


Leu Ile Phe Arg Glu Asn Thr Leu Ala Thr Lys Ala Ile Glu Glu Tyr 
                485                 490                 495     


Met Arg Leu Ile Gly Gln Lys Tyr Leu Lys Asp Ala Ile Gly Glu Phe 
            500                 505                 510         


Ile Arg Ala Leu Tyr Glu Ser Glu Glu Asn Cys Glu Val Asp Pro Ile 
        515                 520                 525             


Lys Cys Thr Ala Ser Ser Leu Ala Glu His Gln Ala Asn Leu Arg Met 
    530                 535                 540                 


Cys Cys Glu Leu Ala Leu Cys Lys Val Val Asn Ser His Cys Val Phe 
545                 550                 555                 560 


Pro Arg Glu Leu Lys Glu Val Phe Ala Ser Trp Arg Leu Arg Cys Ala 
                565                 570                 575     


Glu Arg Gly Arg Glu Asp Ile Ala Asp Arg Leu Ile Ser Ala Ser Leu 
            580                 585                 590         


Phe Leu Arg Phe Leu Cys Pro Ala Ile Met Ser Pro Ser Leu Phe Gly 
        595                 600                 605             


Leu Met Gln Glu Tyr Pro Asp Glu Gln Thr Ser Arg Thr Leu Thr Leu 
    610                 615                 620                 


Ile Ala Lys Val Ile Gln Asn Leu Ala Asn Phe Ser Lys Phe Thr Ser 
625                 630                 635                 640 


Lys Glu Asp Phe Leu Gly Phe Met Asn Glu Phe Leu Glu Leu Glu Trp 
                645                 650                 655     


Gly Ser Met Gln Gln Phe Leu Tyr Glu Ile Ser Asn Leu Asp Thr Leu 
            660                 665                 670         


Thr Asn Ser Ser Ser Phe Glu Gly Tyr Ile Asp Leu Gly Arg Glu Leu 
        675                 680                 685             


Ser Thr Leu His Ala Leu Leu Trp Glu Val Leu Pro Gln Leu Ser Lys 
    690                 695                 700                 


Glu Ala Leu Leu Lys Leu Gly Pro Leu Pro Arg Leu Leu Asn Asp Ile 
705                 710                 715                 720 


Ser Thr Ala Leu Arg Asn Pro Asn Ile Gln Arg Gln Pro Ser Arg Gln 
                725                 730                 735     


Ser Glu Arg Pro Arg Pro Gln Pro Val Val Leu Arg Gly Pro Ser Ala 
            740                 745                 750         


Glu Met Gln Gly Tyr Met Met Arg Asp Leu Asn Ser Ser Ile Asp Leu 
        755                 760                 765             


Gln Ser Phe Met Ala Arg Gly Leu Asn Ser Ser Met Asp Met Ala Arg 
    770                 775                 780                 


Leu Pro Ser Pro Thr Lys Glu Lys Pro Pro Pro Pro Pro Pro Gly Gly 
785                 790                 795                 800 


Gly Lys Asp Leu Phe Tyr Val Ser Arg Pro Pro Arg Pro Val Pro His 
                805                 810                 815     


Gln His Thr Ala Arg Ala Ala Arg Thr Ser Gln Ser Gln Ser Arg Arg 
            820                 825                 830         


Cys 
    


<210>  11
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  11
ggtctcgagc ctccatccat c                                               21


<210>  12
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  12
ttttccccaa cccaatcctt ctac                                            24


<210>  13
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  13
cttgccattt taggcctctg                                                 20


<210>  14
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  14
agtctcaatg gccaccctc                                                  19


<210>  15
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  15
cttcctggga ggaggcg                                                    17


<210>  16
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  16
cagcccggtc catcttc                                                    17


<210>  17
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  17
gggaacctgg gttaacagc                                                  19


<210>  18
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  18
tctttctcag actcctaggg c                                               21


<210>  19
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  19
atccaggggc tctctaccag                                                 20


<210>  20
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  20
cccctccctc tgcatctc                                                   18


<210>  21
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  21
aagttgcagc aagccgag                                                   18


<210>  22
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  22
cctacccttt cctccagtcc                                                 20


<210>  23
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  23
gggaggaaga gaaggtagca g                                               21


<210>  24
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  24
actttcctcc ctaggcccc                                                  19


<210>  25
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  25
ttgcagggat cctgtttcc                                                  19


<210>  26
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  26
tgctcgcccc agaagac                                                    17


<210>  27
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  27
tactgtgagc tctgcctgg                                                  19


<210>  28
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  28
tgctctgtga agtggcg                                                    17


<210>  29
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  29
gaaggacaag gcaggctatg                                                 20


<210>  30
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  30
gccctgtcct cactaaccc                                                  19


<210>  31
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  31
agtgaggaca gggcaaattc                                                 20


<210>  32
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  32
aagctgtgga agggtggac                                                  19


<210>  33
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  33
cagatgtcca ccccagacc                                                  19


<210>  34
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  34
aatttgtccc cattctggtg                                                 20


<210>  35
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  35
ctggaagctg agggtctctg                                                 20


<210>  36
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  36
agacccttct tgccgacc                                                   18


<210>  37
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  37
gggaggctat gataccttgt g                                               21


<210>  38
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  38
agggtagttt ctcaggctcc                                                 20


<210>  39
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  39
ctatcccaac tcaggcccc                                                  19


<210>  40
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a synthesized primer

<400>  40
gggcccagtg aggagtatc                                                  19


<210>  41
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  41
ccgcctctcc tttcatttg                                                  19


<210>  42
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  42
agaggagtag ggcgaaggc                                                  19


<210>  43
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  43
ccagaccaca gcaaggttc                                                  19


<210>  44
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  44
tctgtggtga cacccatctg                                                 20


<210>  45
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  45
cgctgacagc agccttg                                                    17


<210>  46
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  46
agcatgtgct gcaggttg                                                   18


<210>  47
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  47
ccccctgctg cctccatcct tcat                                            24


<210>  48
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  48
aagcccccag ctggccctat tcc                                             23


<210>  49
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  49
gtctcctttg gctgtgctg                                                  19


<210>  50
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  50
ggaagtgact agagatctcc cc                                              22


<210>  51
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  51
acagggatgg aggctgg                                                    17


<210>  52
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  52
tttggggatg ggagtcag                                                   18


<210>  53
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  53
tccagagagc tatggggttc                                                 20


<210>  54
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  54
gctaggtggc tggtgtagtg                                                 20


<210>  55
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  55
ctatagggga ggccactgc                                                  19


<210>  56
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence is a chemically synthesized primer

<400>  56
atgtccaatc ctggtggttg                                                 20


