                               SEQUENCE LISTING

<110> ALBITAR, MAHER
 
<120> BCR-ABL VARIANTS

<130> 054769-0351

<140> 12/472,319
<141> 2009-05-26

<150> 61/110,512
<151> 2008-10-31

<160> 30    

<170> PatentIn version 3.5

<210> 1
<211> 278
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic polynucleotide

<400> 1
catttggagt attgctttgg gaaattgcta cctatggcat gtccccttac ccgggaattg       60

acctgtccca ggtgtatgag ctgctagaga aggactaccg catggagcgc ccagaaggct      120

gcccagagaa ggtctatgaa ctcatgcgag catactttga taaccgtgaa gaaagaacaa      180

gatagaaggt tggcagtgga atccctctga ccggccctcc tttgctgaaa tccaccaagc      240

ctttgaaaca atgttccagg aatccagtat ctcagacg                              278


<210> 2
<211> 48
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic polypeptide

<400> 2
Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val Tyr Glu Leu Leu 
1               5                   10                  15      


Glu Lys Asp Tyr Arg Met Glu Arg Pro Glu Gly Cys Pro Glu Lys Val 
            20                  25                  30          


Tyr Glu Leu Met Arg Ala Tyr Phe Asp Asn Arg Glu Glu Arg Thr Arg 
        35                  40                  45              


<210> 3
<211> 1737
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic polynucleotide

<400> 3
catttggagt attgctttgg gaaattgcta cctatggcat gtccccttac ccgggaattg       60

acctgtccca ggtgtatgag ctgctagaga aggactaccg catggagcgc ccagaaggct      120

gcccagagaa ggtctatgaa ctcatgcgta agccttcctc agcctgttct cacgagtata      180

tgtgggcatt ccaggaaatt caactgtgca ggagtgtgta cacaaagttg aaagtttttc      240

catgagctct ctccattcca gttcttcaga tgcagctaat gtagccattt gctacctatt      300

gacctttatt tacagataaa tagtatgtgc gtgacttgtc ttttaaagca aaaatggtat      360

tgatagatac caaacctggg tgtattccta aatacagatt cctgggccct gctttcacag      420

acattctgct atagtagcta agctcatgag gtgatttttt tttttttttt ttttgagacg      480

gagtttcgct cttgtcgccc aggctggagt acaatggcgc aatgttggct cacttcaacc      540

tccacctccc tggttcaagc gattctcctg cctcagcctc ccaagtagct gggattacag      600

gcatgcacca ccacgcccgg ctaattttgt atttttagta gagatggggt ttctccatgt      660

tagtcaggct ggtctccaac tcccaacctc aggtgatctg cctgcctcgg cctcccaaag      720

tgctgcgatt acaggcgtga gccaccacgc ccagctgcga ggtgattttt atctggtcgt      780

tttatactga ttacatatgt gttatctgta ctatgcacac acaggatgtt ttcatatatc      840

ttataaggta tttatatggc catttcttac actgttttcc cacacatgtc tttccacgtc      900

catatattca gatctctccc tctccctacc tcttatttat gtatagctgc ccagtactcc      960

atttcactca ttcatccggt cctcttttga tgtgcatttg gttgttttac acatttgttt     1020

ggtttttgcc cttataaaca aagcagaaac aaatattcat gtacacgaat ctctgggcac     1080

tttggctggt atttctaaaa gttgaactgt tggttccaag aactgtgtgg gttttaaatt     1140

ttgatacatt ttaccaaact gttaaaaaag gttgtgccat tgtatgctcc agtcagacgc     1200

atatgggagt gactgttcct ggtccccagt actaggcttt gtcagtctgt ttagtcctca     1260

tgttagtctc attttcatga gaatttcttt acttcagact ttgataaccg tgaagaaaga     1320

acaagataga aggtgagctg tttggcttag taattttcta cacctactag agcgggactg     1380

ggaaaaatat atttgtaaat gcagttcttg ctgtcactgt ctctctgggg ttttacaatc     1440

catattcctg ccagcatcta acgtcttttc aaattcttaa tgtctataac aggacatgat     1500

gacattcatc gttttgactt gttgcagcaa aagatggtta gcaggattgg aatgttgctt     1560

tcattctaga cttttccttg agaactgcta gccccgtatt gctagccaga tctcatggat     1620

gatctgactt gggtttcatc tgtccaggtt ggcagtggaa tccctctgac cggccctcct     1680

ttgctgaaat ccaccaagcc tttgaaacaa tgttccagga atccagtatc tcagacg        1737


<210> 4
<211> 35
<212> DNA
<213> Homo sapiens

<400> 4
actttgataa ccgtgaagaa agaacaagat agaag                                  35


<210> 5
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic primer

<400> 5
tgaccaactc gtgtgtgaaa ctc                                               23


<210> 6
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic primer

<400> 6
tccacttcgt ctgagatact ggatt                                             25


<210> 7
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic primer

<400> 7
cgcaacaagc ccactgtct                                                    19


<210> 8
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic primer

<400> 8
tggtagggga gaaccacttg                                                   20


<210> 9
<211> 47
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic oligonucleotide

<400> 9
gagcatactt tgataaccgt gaagaaagaa caagatagaa ggttggc                     47


<210> 10
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 10
Tyr Phe Asp Asn Arg Glu Glu Arg Thr Arg 
1               5                   10  


<210> 11
<211> 1644
<212> PRT
<213> Homo sapiens

<400> 11
Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Thr Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Thr Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Met Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Thr Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Thr Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Thr Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Thr Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Thr Thr Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Thr Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Thr Ile Val Gly Val Arg Lys Thr Gly Gln Ile Trp Pro Asn 
                405                 410                 415     


Asp Gly Glu Gly Ala Phe His Gly Asp Ala Asp Gly Ser Phe Gly Thr 
            420                 425                 430         


Pro Pro Gly Tyr Gly Cys Ala Ala Asp Arg Ala Glu Glu Gln Arg Arg 
        435                 440                 445             


His Gln Asp Gly Leu Pro Tyr Ile Asp Asp Ser Pro Ser Ser Ser Pro 
    450                 455                 460                 


His Leu Ser Ser Lys Gly Arg Gly Ser Arg Asp Ala Leu Val Ser Gly 
465                 470                 475                 480 


Ala Leu Glu Ser Thr Lys Ala Ser Glu Leu Asp Leu Glu Lys Gly Leu 
                485                 490                 495     


Glu Met Arg Lys Trp Val Leu Ser Gly Ile Leu Ala Ser Glu Glu Thr 
            500                 505                 510         


Tyr Leu Ser His Leu Gln Met Leu Thr Asn Ser Cys Val Lys Leu Gln 
        515                 520                 525             


Thr Val His Ser Ile Pro Leu Thr Ile Asn Lys Glu Glu Ala Leu Gln 
    530                 535                 540                 


Arg Pro Val Ala Ser Asp Phe Glu Pro Gln Gly Leu Ser Glu Ala Ala 
545                 550                 555                 560 


Arg Trp Asn Ser Lys Glu Asn Leu Leu Ala Gly Pro Ser Glu Asn Asp 
                565                 570                 575     


Pro Asn Leu Phe Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn 
            580                 585                 590         


Thr Leu Ser Ile Thr Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn 
        595                 600                 605             


His Asn Gly Glu Trp Cys Glu Ala Gln Thr Lys Asn Gly Gln Gly Trp 
    610                 615                 620                 


Val Pro Ser Asn Tyr Ile Thr Pro Val Asn Ser Leu Glu Lys His Ser 
625                 630                 635                 640 


Trp Tyr His Gly Pro Val Ser Arg Asn Ala Ala Glu Tyr Leu Leu Ser 
                645                 650                 655     


Ser Gly Ile Asn Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro 
            660                 665                 670         


Gly Gln Arg Ser Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr 
        675                 680                 685             


Arg Ile Asn Thr Ala Ser Asp Gly Lys Leu Tyr Val Ser Ser Glu Ser 
    690                 695                 700                 


Arg Phe Asn Thr Leu Ala Glu Leu Val His His His Ser Thr Val Ala 
705                 710                 715                 720 


Asp Gly Leu Ile Thr Thr Leu His Tyr Pro Ala Pro Lys Arg Asn Lys 
                725                 730                 735     


Pro Thr Val Tyr Gly Val Ser Pro Asn Tyr Asp Lys Trp Glu Met Glu 
            740                 745                 750         


Arg Thr Asp Ile Thr Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly 
        755                 760                 765             


Glu Val Tyr Glu Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val 
    770                 775                 780                 


Lys Thr Leu Lys Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu 
785                 790                 795                 800 


Ala Ala Val Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu 
                805                 810                 815     


Gly Val Cys Thr Arg Glu Pro Pro Phe Tyr Ile Ile Thr Glu Phe Met 
            820                 825                 830         


Thr Tyr Gly Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Gln Glu 
        835                 840                 845             


Val Asn Ala Val Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala 
    850                 855                 860                 


Met Glu Tyr Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala 
865                 870                 875                 880 


Arg Asn Cys Leu Val Gly Glu Asn His Leu Val Lys Val Ala Asp Phe 
                885                 890                 895     


Gly Leu Ser Arg Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly 
            900                 905                 910         


Ala Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn 
        915                 920                 925             


Lys Phe Ser Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp 
    930                 935                 940                 


Glu Ile Ala Thr Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser 
945                 950                 955                 960 


Gln Val Tyr Glu Leu Leu Glu Lys Asp Tyr Arg Met Glu Arg Pro Glu 
                965                 970                 975     


Gly Cys Pro Glu Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Gln Trp 
            980                 985                 990         


Asn Pro Ser Asp Arg Pro Ser Phe  Ala Glu Ile His Gln  Ala Phe Glu 
        995                 1000                 1005             


Thr Met  Phe Gln Glu Ser Ser  Ile Ser Asp Glu Val  Glu Lys Glu 
    1010                 1015                 1020             


Leu Gly  Lys Gln Gly Val Arg  Gly Ala Val Ser Thr  Leu Leu Gln 
    1025                 1030                 1035             


Ala Pro  Glu Leu Pro Thr Lys  Thr Arg Thr Ser Arg  Arg Ala Ala 
    1040                 1045                 1050             


Glu His  Arg Asp Thr Thr Asp  Val Pro Glu Met Pro  His Ser Lys 
    1055                 1060                 1065             


Gly Gln  Gly Glu Ser Asp Pro  Leu Asp His Glu Pro  Ala Val Ser 
    1070                 1075                 1080             


Pro Leu  Leu Pro Arg Lys Glu  Arg Gly Pro Pro Glu  Gly Gly Leu 
    1085                 1090                 1095             


Asn Glu  Asp Glu Arg Leu Leu  Pro Lys Asp Lys Lys  Thr Asn Leu 
    1100                 1105                 1110             


Phe Ser  Ala Leu Ile Lys Lys  Lys Lys Lys Thr Ala  Pro Thr Pro 
    1115                 1120                 1125             


Pro Lys  Arg Ser Ser Ser Phe  Arg Glu Met Asp Gly  Gln Pro Glu 
    1130                 1135                 1140             


Arg Arg  Gly Ala Gly Glu Glu  Glu Gly Arg Asp Ile  Ser Asn Gly 
    1145                 1150                 1155             


Ala Leu  Ala Phe Thr Pro Leu  Asp Thr Ala Asp Pro  Ala Lys Ser 
    1160                 1165                 1170             


Pro Lys  Pro Ser Asn Gly Ala  Gly Val Pro Asn Gly  Ala Leu Arg 
    1175                 1180                 1185             


Glu Ser  Gly Gly Ser Gly Phe  Arg Ser Pro His Leu  Trp Lys Lys 
    1190                 1195                 1200             


Ser Ser  Thr Leu Thr Ser Ser  Arg Leu Ala Thr Gly  Glu Glu Glu 
    1205                 1210                 1215             


Gly Gly  Gly Ser Ser Ser Lys  Arg Phe Leu Arg Ser  Cys Ser Ala 
    1220                 1225                 1230             


Ser Cys  Val Pro His Gly Ala  Lys Asp Thr Glu Trp  Arg Ser Val 
    1235                 1240                 1245             


Thr Leu  Pro Arg Asp Leu Gln  Ser Thr Gly Arg Gln  Phe Asp Ser 
    1250                 1255                 1260             


Ser Thr  Phe Gly Gly His Lys  Ser Glu Lys Pro Ala  Leu Pro Arg 
    1265                 1270                 1275             


Lys Arg  Ala Gly Glu Asn Arg  Ser Asp Gln Val Thr  Arg Gly Thr 
    1280                 1285                 1290             


Val Thr  Pro Pro Pro Arg Leu  Val Lys Lys Asn Glu  Glu Ala Ala 
    1295                 1300                 1305             


Asp Glu  Val Phe Lys Asp Ile  Met Glu Ser Ser Pro  Gly Ser Ser 
    1310                 1315                 1320             


Pro Pro  Asn Leu Thr Pro Lys  Pro Leu Arg Arg Gln  Val Thr Val 
    1325                 1330                 1335             


Ala Pro  Ala Ser Gly Leu Pro  His Lys Glu Glu Ala  Gly Lys Gly 
    1340                 1345                 1350             


Ser Ala  Leu Gly Thr Pro Ala  Ala Ala Glu Pro Val  Thr Pro Thr 
    1355                 1360                 1365             


Ser Lys  Ala Gly Ser Gly Ala  Pro Gly Gly Thr Ser  Lys Gly Pro 
    1370                 1375                 1380             


Ala Glu  Glu Ser Arg Val Arg  Arg His Lys His Ser  Ser Glu Ser 
    1385                 1390                 1395             


Pro Gly  Arg Asp Lys Gly Lys  Leu Ser Arg Leu Lys  Pro Ala Pro 
    1400                 1405                 1410             


Pro Pro  Pro Pro Ala Ala Ser  Ala Gly Lys Ala Gly  Gly Lys Pro 
    1415                 1420                 1425             


Ser Gln  Ser Pro Ser Gln Glu  Ala Ala Gly Glu Ala  Val Leu Gly 
    1430                 1435                 1440             


Ala Lys  Thr Lys Ala Thr Ser  Leu Val Asp Ala Val  Asn Ser Asp 
    1445                 1450                 1455             


Ala Ala  Lys Pro Ser Gln Pro  Gly Glu Gly Leu Lys  Lys Pro Val 
    1460                 1465                 1470             


Leu Pro  Ala Thr Pro Lys Pro  Gln Ser Ala Lys Pro  Ser Gly Thr 
    1475                 1480                 1485             


Pro Ile  Ser Pro Ala Pro Val  Pro Ser Thr Leu Pro  Ser Ala Ser 
    1490                 1495                 1500             


Ser Ala  Leu Ala Gly Asp Gln  Pro Ser Ser Thr Ala  Phe Ile Pro 
    1505                 1510                 1515             


Leu Ile  Ser Thr Arg Val Ser  Leu Arg Lys Thr Arg  Gln Pro Pro 
    1520                 1525                 1530             


Glu Arg  Ile Ala Ser Gly Ala  Ile Thr Lys Gly Val  Val Leu Asp 
    1535                 1540                 1545             


Ser Thr  Glu Ala Leu Cys Leu  Ala Ile Ser Arg Asn  Ser Glu Gln 
    1550                 1555                 1560             


Met Ala  Ser His Ser Ala Val  Leu Glu Ala Gly Lys  Asn Leu Tyr 
    1565                 1570                 1575             


Thr Phe  Cys Val Ser Tyr Val  Asp Ser Ile Gln Gln  Met Arg Asn 
    1580                 1585                 1590             


Lys Phe  Ala Phe Arg Glu Ala  Ile Asn Lys Leu Glu  Asn Asn Leu 
    1595                 1600                 1605             


Arg Glu  Leu Gln Ile Cys Pro  Ala Thr Ala Gly Ser  Gly Pro Ala 
    1610                 1615                 1620             


Ala Thr  Gln Asp Phe Ser Lys  Leu Leu Ser Ser Val  Lys Glu Ile 
    1625                 1630                 1635             


Ser Asp  Ile Val Gln Arg 
    1640                 


<210> 12
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic peptide

<400> 12
Glu Leu Met Arg Ala Tyr Phe Asp Asn Arg Glu Glu Arg Thr Arg 
1               5                   10                  15  


<210> 13
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic oligonucleotide

<400> 13
gagcatactt tg                                                           12


<210> 14
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic oligonucleotide

<400> 14
tagaaggttg gc                                                           12


<210> 15
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic oligonucleotide

<400> 15
aactcatgcg agcatacttt gataaccgtg                                        30


<210> 16
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic oligonucleotide

<400> 16
atgcgagcat actttgataa                                                   20


<210> 17
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic oligonucleotide

<400> 17
agaacaagat agaaggttgg cagtggaatc                                        30


<210> 18
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic oligonucleotide

<400> 18
gaaggttggc agtggaatcc                                                   20


<210> 19
<211> 4902
<212> DNA
<213> Homo sapiens

<400> 19
atggtggacc cggtgggctt cgcggaggcg tggaaggcgc agttcccgga ctcagagccc       60

ccgcgcatgg agctgcgctc agtgggcgac atcgagcagg agctggagcg ctgcaaggcc      120

tccattcggc gcctggagca ggaggtgaac caggagcgct tccgcatgat ctacctgcag      180

acgttgctgg ccaaggaaaa gaagagctat gaccggcagc gatggggctt ccggcgcgcg      240

gcgcaggccc ccgacggcgc ctccgagccc cgagcgtccg cgtcgcgccc gcagccagcg      300

cccgccgacg gagccgaccc gccgcccgcc gaggagcccg aggcccggcc cgacggcgag      360

ggttctccgg gtaaggccag gcccgggacc gcccgcaggc ccggggcagc cgcgtcgggg      420

gaacgggacg accggggacc ccccgccagc gtggcggcgc tcaggtccaa cttcgagcgg      480

atccgcaagg gccatggcca gcccggggcg gacgccgaga agcccttcta cgtgaacgtc      540

gagtttcacc acgagcgcgg cctggtgaag gtcaacgaca aagaggtgtc ggaccgcatc      600

agctccctgg gcagccaggc catgcagatg gagcgcaaaa agtcccagca cggcgcgggc      660

tcgagcgtgg gggatgcatc caggccccct taccggggac gctcctcgga gagcagctgc      720

ggcgtcgacg gcgactacga ggacgccgag ttgaaccccc gcttcctgaa ggacaacctg      780

atcgacgcca atggcggtag caggccccct tggccgcccc tggagtacca gccctaccag      840

agcatctacg tcgggggcat gatggaaggg gagggcaagg gcccgctcct gcgcagccag      900

agcacctctg agcaggagaa gcgccttacc tggccccgca ggtcctactc cccccggagt      960

tttgaggatt gcggaggcgg ctataccccg gactgcagct ccaatgagaa cctcacctcc     1020

agcgaggagg acttctcctc tggccagtcc agccgcgtgt ccccaagccc caccacctac     1080

cgcatgttcc gggacaaaag ccgctctccc tcgcagaact cgcaacagtc cttcgacagc     1140

agcagtcccc ccacgccgca gtgccataag cggcaccggc actgcccggt tgtcgtgtcc     1200

gaggccacca tcgtgggcgt ccgcaagacc gggcagatct ggcccaacga tggcgagggc     1260

gccttccatg gagacgcaga tggctcgttc ggaacaccac ctggatacgg ctgcgctgca     1320

gaccgggcag aggagcagcg ccggcaccaa gatgggctgc cctacattga tgactcgccc     1380

tcctcatcgc cccacctcag cagcaagggc aggggcagcc gggatgcgct ggtctcggga     1440

gccctggagt ccactaaagc gagtgagctg gacttggaaa agggcttgga gatgagaaaa     1500

tgggtcctgt cgggaatcct ggctagcgag gagacttacc tgagccacct ggaggcactg     1560

ctgctgccca tgaagccttt gaaagccgct gccaccacct ctcagccggt gctgacgagt     1620

cagcagatcg agaccatctt cttcaaagtg cctgagctct acgagatcca caaggagttc     1680

tatgatgggc tcttcccccg cgtgcagcag tggagccacc agcagcgggt gggcgacctc     1740

ttccagaagc tggccagcca gctgggtgtg taccgggtct taggctataa tcacaatggg     1800

gaatggtgtg aagcccaaac caaaaatggc caaggctggg tcccaagcaa ctacatcacg     1860

ccagtcaaca gtctggagaa acactcctgg taccatgggc ctgtgtcccg caatgccgct     1920

gagtatctgc tgagcagcgg gatcaatggc agcttcttgg tgcgtgagag tgagagcagt     1980

cctggccaga ggtccatctc gctgagatac gaagggaggg tgtaccatta caggatcaac     2040

actgcttctg atggcaagct ctacgtctcc tccgagagcc gcttcaacac cctggccgag     2100

ttggttcatc atcattcaac ggtggccgac gggctcatca ccacgctcca ttatccagcc     2160

ccaaagcgca acaagcccac tgtctatggt gtgtccccca actacgacaa gtgggagatg     2220

gaacgcacgg acatcaccat gaagcacaag ctgggcgggg gccagtacgg ggaggtgtac     2280

gagggcgtgt ggaagaaata cagcctgacg gtggccgtga agaccttgaa ggaggacacc     2340

atggaggtgg aagagttctt gaaagaagct gcagtcatga aagagatcaa acaccctaac     2400

ctggtgcagc tccttggggt ctgcacccgg gagcccccgt tctatatcat cactgagttc     2460

atgacctacg ggaacctcct ggactacctg agggagtgca accggcagga ggtgaacgcc     2520

gtggtgctgc tgtacatggc cactcagatc tcgtcagcca tggagtacct ggagaagaaa     2580

aacttcatcc acagagatct tgctgcccga aactgcctgg taggggagaa ccacttggtg     2640

aaggtagctg attttggcct gagcaggttg atgacagggg acacctacac agcccatgct     2700

ggagccaagt tccccatcaa atggactgca cccgagagcc tggcctacaa caagttctcc     2760

atcaagtccg acgtctgggc atttggagta ttgctttggg aaattgctac ctatggcatg     2820

tccccttacc cgggaattga cctgtcccag gtgtatgagc tgctagagaa ggactaccgc     2880

atggagcgcc cagaaggctg cccagagaag gtctatgaac tcatgcgagc atgttggcag     2940

tggaatccct ctgaccggcc ctcctttgct gaaatccacc aagcctttga aacaatgttc     3000

caggaatcca gtatctcaga cgaagtggaa aaggagctgg ggaaacaagg cgtccgtggg     3060

gctgtgagta ccttgctgca ggccccagag ctgcccacca agacgaggac ctccaggaga     3120

gctgcagagc acagagacac cactgacgtg cctgagatgc ctcactccaa gggccaggga     3180

gagagcgatc ctctggacca tgagcctgcc gtgtctccat tgctccctcg aaaagagcga     3240

ggtcccccgg agggcggcct gaatgaagat gagcgccttc tccccaaaga caaaaagacc     3300

aacttgttca gcgccttgat caagaagaag aagaagacag ccccaacccc tcccaaacgc     3360

agcagctcct tccgggagat ggacggccag ccggagcgca gaggggccgg cgaggaagag     3420

ggccgagaca tcagcaacgg ggcactggct ttcaccccct tggacacagc tgacccagcc     3480

aagtccccaa agcccagcaa tggggctggg gtccccaatg gagccctccg ggagtccggg     3540

ggctcaggct tccggtctcc ccacctgtgg aagaagtcca gcacgctgac cagcagccgc     3600

ctagccaccg gcgaggagga gggcggtggc agctccagca agcgcttcct gcgctcttgc     3660

tccgcctcct gcgttcccca tggggccaag gacacggagt ggaggtcagt cacgctgcct     3720

cgggacttgc agtccacggg aagacagttt gactcgtcca catttggagg gcacaaaagt     3780

gagaagccgg ctctgcctcg gaagagggca ggggagaaca ggtctgacca ggtgacccga     3840

ggcacagtaa cgcctccccc caggctggtg aaaaagaatg aggaagctgc tgatgaggtc     3900

ttcaaagaca tcatggagtc cagcccgggc tccagcccgc ccaacctgac tccaaaaccc     3960

ctccggcggc aggtcaccgt ggcccctgcc tcgggcctcc cccacaagga agaagctgga     4020

aagggcagtg ccttagggac ccctgctgca gctgagccag tgacccccac cagcaaagca     4080

ggctcaggtg caccaggggg caccagcaag ggccccgccg aggagtccag agtgaggagg     4140

cacaagcact cctctgagtc gccagggagg gacaagggga aattgtccag gctcaaacct     4200

gccccgccgc ccccaccagc agcctctgca gggaaggctg gaggaaagcc ctcgcagagc     4260

ccgagccagg aggcggccgg ggaggcagtc ctgggcgcaa agacaaaagc cacgagtctg     4320

gttgatgctg tgaacagtga cgctgccaag cccagccagc cgggagaggg cctcaaaaag     4380

cccgtgctcc cggccactcc aaagccacag tccgccaagc cgtcggggac ccccatcagc     4440

ccagcccccg ttccctccac gttgccatca gcatcctcgg ccctggcagg ggaccagccg     4500

tcttccaccg ccttcatccc tctcatatca acccgagtgt ctcttcggaa aacccgccag     4560

cctccagagc ggatcgccag cggcgccatc accaagggcg tggtcctgga cagcaccgag     4620

gcgctgtgcc tcgccatctc taggaactcc gagcagatgg ccagccacag cgcagtgctg     4680

gaggccggca aaaacctcta cacgttctgc gtgagctatg tggattccat ccagcaaatg     4740

aggaacaagt ttgccttccg agaggccatc aacaaactgg agaataatct ccgggagctt     4800

cagatctgcc cggcgacagc aggcagtggt ccggcggcca ctcaggactt cagcaagctc     4860

ctcagttcgg tgaaggaaat cagtgacata gtgcagaggt ag                        4902


<210> 20
<211> 998
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic polypeptide

<400> 20
Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Thr Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Thr Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Met Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Thr Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Thr Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Thr Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Thr Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Thr Thr Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Thr Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Thr Ile Val Gly Val Arg Lys Thr Gly Gln Ile Trp Pro Asn 
                405                 410                 415     


Asp Gly Glu Gly Ala Phe His Gly Asp Ala Asp Gly Ser Phe Gly Thr 
            420                 425                 430         


Pro Pro Gly Tyr Gly Cys Ala Ala Asp Arg Ala Glu Glu Gln Arg Arg 
        435                 440                 445             


His Gln Asp Gly Leu Pro Tyr Ile Asp Asp Ser Pro Ser Ser Ser Pro 
    450                 455                 460                 


His Leu Ser Ser Lys Gly Arg Gly Ser Arg Asp Ala Leu Val Ser Gly 
465                 470                 475                 480 


Ala Leu Glu Ser Thr Lys Ala Ser Glu Leu Asp Leu Glu Lys Gly Leu 
                485                 490                 495     


Glu Met Arg Lys Trp Val Leu Ser Gly Ile Leu Ala Ser Glu Glu Thr 
            500                 505                 510         


Tyr Leu Ser His Leu Gln Met Leu Thr Asn Ser Cys Val Lys Leu Gln 
        515                 520                 525             


Thr Val His Ser Ile Pro Leu Thr Ile Asn Lys Glu Glu Ala Leu Gln 
    530                 535                 540                 


Arg Pro Val Ala Ser Asp Phe Glu Pro Gln Gly Leu Ser Glu Ala Ala 
545                 550                 555                 560 


Arg Trp Asn Ser Lys Glu Asn Leu Leu Ala Gly Pro Ser Glu Asn Asp 
                565                 570                 575     


Pro Asn Leu Phe Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn 
            580                 585                 590         


Thr Leu Ser Ile Thr Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn 
        595                 600                 605             


His Asn Gly Glu Trp Cys Glu Ala Gln Thr Lys Asn Gly Gln Gly Trp 
    610                 615                 620                 


Val Pro Ser Asn Tyr Ile Thr Pro Val Asn Ser Leu Glu Lys His Ser 
625                 630                 635                 640 


Trp Tyr His Gly Pro Val Ser Arg Asn Ala Ala Glu Tyr Leu Leu Ser 
                645                 650                 655     


Ser Gly Ile Asn Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro 
            660                 665                 670         


Gly Gln Arg Ser Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr 
        675                 680                 685             


Arg Ile Asn Thr Ala Ser Asp Gly Lys Leu Tyr Val Ser Ser Glu Ser 
    690                 695                 700                 


Arg Phe Asn Thr Leu Ala Glu Leu Val His His His Ser Thr Val Ala 
705                 710                 715                 720 


Asp Gly Leu Ile Thr Thr Leu His Tyr Pro Ala Pro Lys Arg Asn Lys 
                725                 730                 735     


Pro Thr Val Tyr Gly Val Ser Pro Asn Tyr Asp Lys Trp Glu Met Glu 
            740                 745                 750         


Arg Thr Asp Ile Thr Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly 
        755                 760                 765             


Glu Val Tyr Glu Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val 
    770                 775                 780                 


Lys Thr Leu Lys Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu 
785                 790                 795                 800 


Ala Ala Val Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu 
                805                 810                 815     


Gly Val Cys Thr Arg Glu Pro Pro Phe Tyr Ile Ile Thr Glu Phe Met 
            820                 825                 830         


Thr Tyr Gly Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Gln Glu 
        835                 840                 845             


Val Asn Ala Val Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala 
    850                 855                 860                 


Met Glu Tyr Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala 
865                 870                 875                 880 


Arg Asn Cys Leu Val Gly Glu Asn His Leu Val Lys Val Ala Asp Phe 
                885                 890                 895     


Gly Leu Ser Arg Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly 
            900                 905                 910         


Ala Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn 
        915                 920                 925             


Lys Phe Ser Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp 
    930                 935                 940                 


Glu Ile Ala Thr Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser 
945                 950                 955                 960 


Gln Val Tyr Glu Leu Leu Glu Lys Asp Tyr Arg Met Glu Arg Pro Glu 
                965                 970                 975     


Gly Cys Pro Glu Lys Val Tyr Glu Leu Met Arg Ala Tyr Phe Asp Asn 
            980                 985                 990         


Arg Glu Glu Arg Thr Arg 
        995             


<210> 21
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic primer

<400> 21
caagtggttc tcccctacca                                                   20


<210> 22
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic primer

<400> 22
cgtctgggca tttggagtat                                                   20


<210> 23
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic primer

<400> 23
tcaaaggctt ggtggatttc                                                   20


<210> 24
<211> 1130
<212> PRT
<213> Homo sapiens

<400> 24
Met Leu Glu Ile Cys Leu Lys Leu Val Gly Cys Lys Ser Lys Lys Gly 
1               5                   10                  15      


Leu Ser Ser Ser Ser Ser Cys Tyr Leu Glu Glu Ala Leu Gln Arg Pro 
            20                  25                  30          


Val Ala Ser Asp Phe Glu Pro Gln Gly Leu Ser Glu Ala Ala Arg Trp 
        35                  40                  45              


Asn Ser Lys Glu Asn Leu Leu Ala Gly Pro Ser Glu Asn Asp Pro Asn 
    50                  55                  60                  


Leu Phe Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Ile Thr Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn His Asn 
                85                  90                  95      


Gly Glu Trp Cys Glu Ala Gln Thr Lys Asn Gly Gln Gly Trp Val Pro 
            100                 105                 110         


Ser Asn Tyr Ile Thr Pro Val Asn Ser Leu Glu Lys His Ser Trp Tyr 
        115                 120                 125             


His Gly Pro Val Ser Arg Asn Ala Ala Glu Tyr Pro Leu Ser Ser Gly 
    130                 135                 140                 


Ile Asn Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro Ser Gln 
145                 150                 155                 160 


Arg Ser Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile 
                165                 170                 175     


Asn Thr Ala Ser Asp Gly Lys Leu Tyr Val Ser Ser Glu Ser Arg Phe 
            180                 185                 190         


Asn Thr Leu Ala Glu Leu Val His His His Ser Thr Val Ala Asp Gly 
        195                 200                 205             


Leu Ile Thr Thr Leu His Tyr Pro Ala Pro Lys Arg Asn Lys Pro Thr 
    210                 215                 220                 


Val Tyr Gly Val Ser Pro Asn Tyr Asp Lys Trp Glu Met Glu Arg Thr 
225                 230                 235                 240 


Asp Ile Thr Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val 
                245                 250                 255     


Tyr Glu Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val Lys Thr 
            260                 265                 270         


Leu Lys Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala 
        275                 280                 285             


Val Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val 
    290                 295                 300                 


Cys Thr Arg Glu Pro Pro Phe Tyr Ile Ile Thr Glu Phe Met Thr Tyr 
305                 310                 315                 320 


Gly Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Gln Glu Val Asn 
                325                 330                 335     


Ala Val Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala Met Glu 
            340                 345                 350         


Tyr Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn 
        355                 360                 365             


Cys Leu Val Gly Glu Asn His Leu Val Lys Val Ala Asp Phe Gly Leu 
    370                 375                 380                 


Ser Arg Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly Ala Lys 
385                 390                 395                 400 


Phe Pro Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn Lys Phe 
                405                 410                 415     


Ser Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile 
            420                 425                 430         


Ala Thr Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Arg Ser Gln Val 
        435                 440                 445             


Tyr Glu Leu Leu Glu Lys Asp Tyr Arg Met Lys Arg Pro Glu Gly Cys 
    450                 455                 460                 


Pro Glu Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Gln Trp Asn Pro 
465                 470                 475                 480 


Ser Asp Arg Pro Ser Phe Ala Glu Ile His Gln Ala Phe Glu Thr Met 
                485                 490                 495     


Phe Gln Glu Ser Ser Ile Ser Asp Glu Val Glu Lys Glu Leu Gly Lys 
            500                 505                 510         


Gln Gly Val Arg Gly Ala Val Thr Thr Leu Leu Gln Ala Pro Glu Leu 
        515                 520                 525             


Pro Thr Lys Thr Arg Thr Ser Arg Arg Ala Ala Glu His Arg Asp Thr 
    530                 535                 540                 


Thr Asp Val Pro Glu Met Pro His Ser Lys Gly Gln Gly Glu Ser Asp 
545                 550                 555                 560 


Pro Leu Asp His Glu Pro Ala Val Ser Pro Leu Leu Pro Arg Lys Glu 
                565                 570                 575     


Arg Gly Pro Pro Glu Gly Gly Leu Asn Glu Asp Glu Arg Leu Leu Pro 
            580                 585                 590         


Lys Asp Lys Lys Thr Asn Leu Phe Ser Ala Leu Ile Lys Lys Lys Lys 
        595                 600                 605             


Lys Thr Ala Pro Thr Pro Pro Lys Arg Ser Ser Ser Phe Arg Glu Met 
    610                 615                 620                 


Asp Gly Gln Pro Glu Arg Arg Gly Ala Gly Glu Glu Glu Gly Arg Asp 
625                 630                 635                 640 


Ile Ser Asn Gly Ala Leu Ala Phe Thr Pro Leu Asp Thr Ala Asp Pro 
                645                 650                 655     


Ala Lys Ser Pro Lys Pro Ser Asn Gly Ala Gly Val Pro Asn Gly Ala 
            660                 665                 670         


Leu Arg Glu Ser Gly Gly Ser Gly Phe Arg Ser Pro His Leu Trp Lys 
        675                 680                 685             


Lys Ser Ser Thr Leu Thr Ser Ser Arg Leu Ala Thr Gly Glu Glu Glu 
    690                 695                 700                 


Gly Gly Gly Ser Ser Ser Lys Arg Phe Leu Arg Ser Cys Ser Val Ser 
705                 710                 715                 720 


Cys Val Pro His Gly Ala Lys Asp Thr Glu Trp Arg Ser Val Thr Leu 
                725                 730                 735     


Pro Arg Asp Leu Gln Ser Thr Gly Arg Gln Phe Asp Ser Ser Thr Phe 
            740                 745                 750         


Gly Gly His Lys Ser Glu Lys Pro Ala Leu Pro Arg Lys Arg Ala Gly 
        755                 760                 765             


Glu Asn Arg Ser Asp Gln Val Thr Arg Gly Thr Val Thr Pro Pro Pro 
    770                 775                 780                 


Arg Leu Val Lys Lys Asn Glu Glu Ala Ala Asp Glu Val Phe Lys Asp 
785                 790                 795                 800 


Ile Met Glu Ser Ser Pro Gly Ser Ser Pro Pro Asn Leu Thr Pro Lys 
                805                 810                 815     


Pro Leu Arg Arg Gln Val Thr Val Ala Pro Ala Ser Gly Leu Pro His 
            820                 825                 830         


Lys Glu Glu Ala Trp Lys Gly Ser Ala Leu Gly Thr Pro Ala Ala Ala 
        835                 840                 845             


Glu Pro Val Thr Pro Thr Ser Lys Ala Gly Ser Gly Ala Pro Arg Gly 
    850                 855                 860                 


Thr Ser Lys Gly Pro Ala Glu Glu Ser Arg Val Arg Arg His Lys His 
865                 870                 875                 880 


Ser Ser Glu Ser Pro Gly Arg Asp Lys Gly Lys Leu Ser Lys Leu Lys 
                885                 890                 895     


Pro Ala Pro Pro Pro Pro Pro Ala Ala Ser Ala Gly Lys Ala Gly Gly 
            900                 905                 910         


Lys Pro Ser Gln Arg Pro Gly Gln Glu Ala Ala Gly Glu Ala Val Leu 
        915                 920                 925             


Gly Ala Lys Thr Lys Ala Thr Ser Leu Val Asp Ala Val Asn Ser Asp 
    930                 935                 940                 


Ala Ala Lys Pro Ser Gln Pro Ala Glu Gly Leu Lys Lys Pro Val Leu 
945                 950                 955                 960 


Pro Ala Thr Pro Lys Pro His Pro Ala Lys Pro Ser Gly Thr Pro Ile 
                965                 970                 975     


Ser Pro Ala Pro Val Pro Leu Ser Thr Leu Pro Ser Ala Ser Ser Ala 
            980                 985                 990         


Leu Ala Gly Asp Gln Pro Ser Ser  Thr Ala Phe Ile Pro  Leu Ile Ser 
        995                 1000                 1005             


Thr Arg  Val Ser Leu Arg Lys  Thr Arg Gln Pro Pro  Glu Arg Ala 
    1010                 1015                 1020             


Ser Gly  Ala Ile Thr Lys Gly  Val Val Leu Asp Ser  Thr Glu Ala 
    1025                 1030                 1035             


Leu Cys  Leu Ala Ile Ser Gly  Asn Ser Glu Gln Met  Ala Ser His 
    1040                 1045                 1050             


Ser Ala  Val Leu Glu Ala Gly  Lys Asn Leu Tyr Thr  Phe Cys Val 
    1055                 1060                 1065             


Ser Tyr  Val Asp Ser Ile Gln  Gln Met Arg Asn Lys  Phe Ala Phe 
    1070                 1075                 1080             


Arg Glu  Ala Ile Asn Lys Leu  Glu Asn Asn Leu Arg  Glu Leu Gln 
    1085                 1090                 1095             


Ile Cys  Pro Ala Ser Ala Gly  Ser Gly Pro Ala Ala  Thr Gln Asp 
    1100                 1105                 1110             


Phe Ser  Lys Leu Leu Ser Ser  Val Lys Glu Ile Ser  Asp Ile Val 
    1115                 1120                 1125             


Gln Arg  
    1130 


<210> 25
<211> 484
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic polypeptide

<400> 25
Met Leu Glu Ile Cys Leu Lys Leu Val Gly Cys Lys Ser Lys Lys Gly 
1               5                   10                  15      


Leu Ser Ser Ser Ser Ser Cys Tyr Leu Glu Glu Ala Leu Gln Arg Pro 
            20                  25                  30          


Val Ala Ser Asp Phe Glu Pro Gln Gly Leu Ser Glu Ala Ala Arg Trp 
        35                  40                  45              


Asn Ser Lys Glu Asn Leu Leu Ala Gly Pro Ser Glu Asn Asp Pro Asn 
    50                  55                  60                  


Leu Phe Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Ile Thr Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn His Asn 
                85                  90                  95      


Gly Glu Trp Cys Glu Ala Gln Thr Lys Asn Gly Gln Gly Trp Val Pro 
            100                 105                 110         


Ser Asn Tyr Ile Thr Pro Val Asn Ser Leu Glu Lys His Ser Trp Tyr 
        115                 120                 125             


His Gly Pro Val Ser Arg Asn Ala Ala Glu Tyr Pro Leu Ser Ser Gly 
    130                 135                 140                 


Ile Asn Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro Ser Gln 
145                 150                 155                 160 


Arg Ser Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile 
                165                 170                 175     


Asn Thr Ala Ser Asp Gly Lys Leu Tyr Val Ser Ser Glu Ser Arg Phe 
            180                 185                 190         


Asn Thr Leu Ala Glu Leu Val His His His Ser Thr Val Ala Asp Gly 
        195                 200                 205             


Leu Ile Thr Thr Leu His Tyr Pro Ala Pro Lys Arg Asn Lys Pro Thr 
    210                 215                 220                 


Val Tyr Gly Val Ser Pro Asn Tyr Asp Lys Trp Glu Met Glu Arg Thr 
225                 230                 235                 240 


Asp Ile Thr Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val 
                245                 250                 255     


Tyr Glu Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val Lys Thr 
            260                 265                 270         


Leu Lys Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala 
        275                 280                 285             


Val Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val 
    290                 295                 300                 


Cys Thr Arg Glu Pro Pro Phe Tyr Ile Ile Thr Glu Phe Met Thr Tyr 
305                 310                 315                 320 


Gly Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Gln Glu Val Asn 
                325                 330                 335     


Ala Val Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala Met Glu 
            340                 345                 350         


Tyr Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn 
        355                 360                 365             


Cys Leu Val Gly Glu Asn His Leu Val Lys Val Ala Asp Phe Gly Leu 
    370                 375                 380                 


Ser Arg Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly Ala Lys 
385                 390                 395                 400 


Phe Pro Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn Lys Phe 
                405                 410                 415     


Ser Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile 
            420                 425                 430         


Ala Thr Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Arg Ser Gln Val 
        435                 440                 445             


Tyr Glu Leu Leu Glu Lys Asp Tyr Arg Met Lys Arg Pro Glu Gly Cys 
    450                 455                 460                 


Pro Glu Lys Val Tyr Glu Leu Met Arg Ala Tyr Phe Asp Asn Arg Glu 
465                 470                 475                 480 


Glu Arg Thr Arg 
                


<210> 26
<211> 4937
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic polynucleotide

<400> 26
atggtggacc cggtgggctt cgcggaggcg tggaaggcgc agttcccgga ctcagagccc       60

ccgcgcatgg agctgcgctc agtgggcgac atcgagcagg agctggagcg ctgcaaggcc      120

tccattcggc gcctggagca ggaggtgaac caggagcgct tccgcatgat ctacctgcag      180

acgttgctgg ccaaggaaaa gaagagctat gaccggcagc gatggggctt ccggcgcgcg      240

gcgcaggccc ccgacggcgc ctccgagccc cgagcgtccg cgtcgcgccc gcagccagcg      300

cccgccgacg gagccgaccc gccgcccgcc gaggagcccg aggcccggcc cgacggcgag      360

ggttctccgg gtaaggccag gcccgggacc gcccgcaggc ccggggcagc cgcgtcgggg      420

gaacgggacg accggggacc ccccgccagc gtggcggcgc tcaggtccaa cttcgagcgg      480

atccgcaagg gccatggcca gcccggggcg gacgccgaga agcccttcta cgtgaacgtc      540

gagtttcacc acgagcgcgg cctggtgaag gtcaacgaca aagaggtgtc ggaccgcatc      600

agctccctgg gcagccaggc catgcagatg gagcgcaaaa agtcccagca cggcgcgggc      660

tcgagcgtgg gggatgcatc caggccccct taccggggac gctcctcgga gagcagctgc      720

ggcgtcgacg gcgactacga ggacgccgag ttgaaccccc gcttcctgaa ggacaacctg      780

atcgacgcca atggcggtag caggccccct tggccgcccc tggagtacca gccctaccag      840

agcatctacg tcgggggcat gatggaaggg gagggcaagg gcccgctcct gcgcagccag      900

agcacctctg agcaggagaa gcgccttacc tggccccgca ggtcctactc cccccggagt      960

tttgaggatt gcggaggcgg ctataccccg gactgcagct ccaatgagaa cctcacctcc     1020

agcgaggagg acttctcctc tggccagtcc agccgcgtgt ccccaagccc caccacctac     1080

cgcatgttcc gggacaaaag ccgctctccc tcgcagaact cgcaacagtc cttcgacagc     1140

agcagtcccc ccacgccgca gtgccataag cggcaccggc actgcccggt tgtcgtgtcc     1200

gaggccacca tcgtgggcgt ccgcaagacc gggcagatct ggcccaacga tggcgagggc     1260

gccttccatg gagacgcaga tggctcgttc ggaacaccac ctggatacgg ctgcgctgca     1320

gaccgggcag aggagcagcg ccggcaccaa gatgggctgc cctacattga tgactcgccc     1380

tcctcatcgc cccacctcag cagcaagggc aggggcagcc gggatgcgct ggtctcggga     1440

gccctggagt ccactaaagc gagtgagctg gacttggaaa agggcttgga gatgagaaaa     1500

tgggtcctgt cgggaatcct ggctagcgag gagacttacc tgagccacct ggaggcactg     1560

ctgctgccca tgaagccttt gaaagccgct gccaccacct ctcagccggt gctgacgagt     1620

cagcagatcg agaccatctt cttcaaagtg cctgagctct acgagatcca caaggagttc     1680

tatgatgggc tcttcccccg cgtgcagcag tggagccacc agcagcgggt gggcgacctc     1740

ttccagaagc tggccagcca gctgggtgtg taccgggtct taggctataa tcacaatggg     1800

gaatggtgtg aagcccaaac caaaaatggc caaggctggg tcccaagcaa ctacatcacg     1860

ccagtcaaca gtctggagaa acactcctgg taccatgggc ctgtgtcccg caatgccgct     1920

gagtatctgc tgagcagcgg gatcaatggc agcttcttgg tgcgtgagag tgagagcagt     1980

cctggccaga ggtccatctc gctgagatac gaagggaggg tgtaccatta caggatcaac     2040

actgcttctg atggcaagct ctacgtctcc tccgagagcc gcttcaacac cctggccgag     2100

ttggttcatc atcattcaac ggtggccgac gggctcatca ccacgctcca ttatccagcc     2160

ccaaagcgca acaagcccac tgtctatggt gtgtccccca actacgacaa gtgggagatg     2220

gaacgcacgg acatcaccat gaagcacaag ctgggcgggg gccagtacgg ggaggtgtac     2280

gagggcgtgt ggaagaaata cagcctgacg gtggccgtga agaccttgaa ggaggacacc     2340

atggaggtgg aagagttctt gaaagaagct gcagtcatga aagagatcaa acaccctaac     2400

ctggtgcagc tccttggggt ctgcacccgg gagcccccgt tctatatcat cactgagttc     2460

atgacctacg ggaacctcct ggactacctg agggagtgca accggcagga ggtgaacgcc     2520

gtggtgctgc tgtacatggc cactcagatc tcgtcagcca tggagtacct ggagaagaaa     2580

aacttcatcc acagagatct tgctgcccga aactgcctgg taggggagaa ccacttggtg     2640

aaggtagctg attttggcct gagcaggttg atgacagggg acacctacac agcccatgct     2700

ggagccaagt tccccatcaa atggactgca cccgagagcc tggcctacaa caagttctcc     2760

atcaagtccg acgtctgggc atttggagta ttgctttggg aaattgctac ctatggcatg     2820

tccccttacc cgggaattga cctgtcccag gtgtatgagc tgctagagaa ggactaccgc     2880

atggagcgcc cagaaggctg cccagagaag gtctatgaac tcatgcgagc atactttgat     2940

aaccgtgaag aaagaacaag atagaaggtt ggcagtggaa tccctctgac cggccctcct     3000

ttgctgaaat ccaccaagcc tttgaaacaa tgttccagga atccagtatc tcagacgaag     3060

tggaaaagga gctggggaaa caaggcgtcc gtggggctgt gagtaccttg ctgcaggccc     3120

cagagctgcc caccaagacg aggacctcca ggagagctgc agagcacaga gacaccactg     3180

acgtgcctga gatgcctcac tccaagggcc agggagagag cgatcctctg gaccatgagc     3240

ctgccgtgtc tccattgctc cctcgaaaag agcgaggtcc cccggagggc ggcctgaatg     3300

aagatgagcg ccttctcccc aaagacaaaa agaccaactt gttcagcgcc ttgatcaaga     3360

agaagaagaa gacagcccca acccctccca aacgcagcag ctccttccgg gagatggacg     3420

gccagccgga gcgcagaggg gccggcgagg aagagggccg agacatcagc aacggggcac     3480

tggctttcac ccccttggac acagctgacc cagccaagtc cccaaagccc agcaatgggg     3540

ctggggtccc caatggagcc ctccgggagt ccgggggctc aggcttccgg tctccccacc     3600

tgtggaagaa gtccagcacg ctgaccagca gccgcctagc caccggcgag gaggagggcg     3660

gtggcagctc cagcaagcgc ttcctgcgct cttgctccgc ctcctgcgtt ccccatgggg     3720

ccaaggacac ggagtggagg tcagtcacgc tgcctcggga cttgcagtcc acgggaagac     3780

agtttgactc gtccacattt ggagggcaca aaagtgagaa gccggctctg cctcggaaga     3840

gggcagggga gaacaggtct gaccaggtga cccgaggcac agtaacgcct ccccccaggc     3900

tggtgaaaaa gaatgaggaa gctgctgatg aggtcttcaa agacatcatg gagtccagcc     3960

cgggctccag cccgcccaac ctgactccaa aacccctccg gcggcaggtc accgtggccc     4020

ctgcctcggg cctcccccac aaggaagaag ctggaaaggg cagtgcctta gggacccctg     4080

ctgcagctga gccagtgacc cccaccagca aagcaggctc aggtgcacca gggggcacca     4140

gcaagggccc cgccgaggag tccagagtga ggaggcacaa gcactcctct gagtcgccag     4200

ggagggacaa ggggaaattg tccaggctca aacctgcccc gccgccccca ccagcagcct     4260

ctgcagggaa ggctggagga aagccctcgc agagcccgag ccaggaggcg gccggggagg     4320

cagtcctggg cgcaaagaca aaagccacga gtctggttga tgctgtgaac agtgacgctg     4380

ccaagcccag ccagccggga gagggcctca aaaagcccgt gctcccggcc actccaaagc     4440

cacagtccgc caagccgtcg gggaccccca tcagcccagc ccccgttccc tccacgttgc     4500

catcagcatc ctcggccctg gcaggggacc agccgtcttc caccgccttc atccctctca     4560

tatcaacccg agtgtctctt cggaaaaccc gccagcctcc agagcggatc gccagcggcg     4620

ccatcaccaa gggcgtggtc ctggacagca ccgaggcgct gtgcctcgcc atctctagga     4680

actccgagca gatggccagc cacagcgcag tgctggaggc cggcaaaaac ctctacacgt     4740

tctgcgtgag ctatgtggat tccatccagc aaatgaggaa caagtttgcc ttccgagagg     4800

ccatcaacaa actggagaat aatctccggg agcttcagat ctgcccggcg acagcaggca     4860

gtggtccggc ggccactcag gacttcagca agctcctcag ttcggtgaag gaaatcagtg     4920

acatagtgca gaggtag                                                    4937


<210> 27
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic primer

<400> 27
gaactcatgc gagcatactt tgataaccgt gaagaaagaa caagatagaa ggttggcagt       60

ggaatc                                                                  66


<210> 28
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic primer

<400> 28
gattccactg ccaaccttct atcttgttct ttcttcacgg ttatcaaagt atgctcgcat       60

gagttc                                                                  66


<210> 29
<211> 274
<212> PRT
<213> Homo sapiens

<400> 29
Met Asp Pro Ser Ser Pro Asn Tyr Asp Lys Trp Glu Met Glu Arg Thr 
1               5                   10                  15      


Asp Ile Thr Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val 
            20                  25                  30          


Tyr Glu Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val Lys Thr 
        35                  40                  45              


Leu Lys Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala 
    50                  55                  60                  


Val Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val 
65                  70                  75                  80  


Cys Thr Arg Glu Pro Pro Phe Tyr Ile Ile Thr Glu Phe Met Thr Tyr 
                85                  90                  95      


Gly Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Gln Glu Val Ser 
            100                 105                 110         


Ala Val Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala Met Glu 
        115                 120                 125             


Tyr Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn 
    130                 135                 140                 


Cys Leu Val Gly Glu Asn His Leu Val Lys Val Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ser Arg Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly Ala Lys 
                165                 170                 175     


Phe Pro Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn Lys Phe 
            180                 185                 190         


Ser Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile 
        195                 200                 205             


Ala Thr Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val 
    210                 215                 220                 


Tyr Glu Leu Leu Glu Lys Asp Tyr Arg Met Glu Arg Pro Glu Gly Cys 
225                 230                 235                 240 


Pro Glu Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Gln Trp Asn Pro 
                245                 250                 255     


Ser Asp Arg Pro Ser Phe Ala Glu Ile His Gln Ala Phe Glu Thr Met 
            260                 265                 270         


Phe Gln 
        


<210> 30
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic polypeptide

<400> 30
Met Asp Pro Ser Ser Pro Asn Tyr Asp Lys Trp Glu Met Glu Arg Thr 
1               5                   10                  15      


Asp Ile Thr Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val 
            20                  25                  30          


Tyr Glu Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val Lys Thr 
        35                  40                  45              


Leu Lys Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala 
    50                  55                  60                  


Val Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val 
65                  70                  75                  80  


Cys Thr Arg Glu Pro Pro Phe Tyr Ile Ile Thr Glu Phe Met Thr Tyr 
                85                  90                  95      


Gly Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Gln Glu Val Ser 
            100                 105                 110         


Ala Val Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala Met Glu 
        115                 120                 125             


Tyr Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn 
    130                 135                 140                 


Cys Leu Val Gly Glu Asn His Leu Val Lys Val Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ser Arg Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly Ala Lys 
                165                 170                 175     


Phe Pro Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn Lys Phe 
            180                 185                 190         


Ser Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile 
        195                 200                 205             


Ala Thr Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val 
    210                 215                 220                 


Tyr Glu Leu Leu Glu Lys Asp Tyr Arg Met Glu Arg Pro Glu Gly Cys 
225                 230                 235                 240 


Pro Glu Lys Val Tyr Glu Leu Met Arg Ala Tyr Phe Asp Asn Arg Glu 
                245                 250                 255     


Glu Arg Thr Arg 
            260 


