<110>   Batelle Energy Alliance, LLC
        Thompson, David N
        Apel, William A
        Vicki, Thompson S
        Reed, David W
	Lacey, Jeffrey A

<120>   THERMOPHILIC AND THERMOACIDOPHILIC GLYCOSYLATION 
	GENES AND ENZYMES FROM ALICYCLOBACILLUS 
	ACIDOCALDARIUS AND RELATED ORGANISMS, METHODS

<130>   2939-8808PC (BA-312)

<150>  	US 61/031,984
<151>  	2008-02-27

<160>   325

<170>	INL Custom Script Ver 1.0 (Author: Cody Permann)

<210>   1
<211>   385
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   1
Met Ser Met Arg Ile Ala Met Phe Thr Glu Thr Phe Leu Pro Ser Thr 
                5                   10                  15      

Asp Gly Ile Val Thr Arg Leu Cys Ala Thr Leu Lys Tyr Leu Glu Arg 
            20                  25                  30          

Glu Gly His Glu Val Leu Leu Phe Ala Pro Ser Gly Ser Pro Glu Thr 
        35                  40                  45              

Tyr Ala Ser Ala Thr Ile Val Gly Ile Pro Ala Met Pro Phe Ile Leu 
    50                  55                  60                  

Tyr Pro Glu Lys Arg Tyr Ser Leu Pro Leu Pro Arg Ile Gly Lys His 
65                  70                  75                  80  

Leu Arg Ala Phe Arg Pro Asp Leu Ile His Val Val Asn Pro Ala Phe 
                85                  90                  95      

Leu Gly Ile Gly Gly Ile Tyr Tyr Ala Trp Lys Ser His Leu Pro Leu 
            100                 105                 110         

Val Ala Ser Tyr His Thr Asn Val Pro Ala Tyr Ala Arg His Tyr Lys 
        115                 120                 125             

Leu Glu Phe Leu Glu Pro Leu Leu Trp Trp Tyr Phe Arg Thr Leu His 
    130                 135                 140                 

Asn Arg Ala His Leu Asn Leu Ala Thr Ser Arg Ala Thr Leu Arg Glu 
145                 150                 155                 160 

Leu Glu Arg Gln Gly Phe Gln Asn Leu Glu Leu Trp Glu Arg Gly Val 
                165                 170                 175     

Asp Val Glu Leu Phe Arg Asn Ala Pro Tyr Ser Glu Glu Met Arg Arg 
            180                 185                 190         

Arg Leu Ala Pro Glu Ala Lys Pro Gly Asp Arg Val Leu Leu Tyr Val 
        195                 200                 205             

Gly Arg Leu Ala Ser Glu Lys Asn Ile Glu Arg Met Arg Pro Val Leu 
    210                 215                 220                 

Asp Ala Ile Pro Asp Leu His Leu Ala Ile Val Gly Asp Gly Pro His 
225                 230                 235                 240 

Arg Pro Glu Leu Glu Arg Val Phe Ala Gly Thr Arg Thr His Phe Thr 
                245                 250                 255     

Gly Tyr Leu His Gly Glu Glu Leu Ala Gln Ala Tyr Arg Ala Ala Asp 
            260                 265                 270         

Ala Phe Leu Phe Pro Ser Thr Thr Glu Thr Leu Gly Leu Val Leu Phe 
        275                 280                 285             

Glu Ala Met Ala Ala Gly Leu Pro Ile Val Ala Ala Asp Ser Pro Pro 
    290                 295                 300                 

Thr Arg Glu Val Leu Glu Asp Gly Arg Ala Gly Phe Ile Phe Asp Pro 
305                 310                 315                 320 

Asp Ser Thr Glu Ser Leu Ile Ala Thr Val Asp Leu Val Met Arg Asp 
                325                 330                 335     

Glu Ala Arg Arg Glu Ala Val Arg Gln Arg Gly Leu Ala Ile Ala Glu 
            340                 345                 350         

Gln Leu Asp Trp Glu Gly Pro Ser Lys Gln Leu Leu Gly His Tyr Glu 
        355                 360                 365             

Arg Val Leu Gln Ser Phe Ser Val Val Ala Gly Ala Val Thr Gly Thr 
    370                 375                 380                 

Arg 
385 

<210>   2
<211>   1158
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   2
gtgagcatga ggatcgcgat gtttacggag acgtttctgc cgtcgaccga cgggatcgtc       60

accaggctct gtgcaacgct gaaatacttg gagcgcgagg gccacgaggt gctgctgttc      120

gccccgtcgg gatcgccgga gacctacgct tccgcaacca tcgtcgggat ccctgcgatg      180

ccgttcatcc tgtatccaga aaagcgatac tcgttgccgc tgccgcgcat cggcaaacat      240

ctgcgggcgt ttcggccgga tctcatccac gtggtgaatc cggcgttcct cggcatcggg      300

ggcatctact acgcgtggaa gtctcatctg ccgctggtgg cctcgtatca caccaacgtg      360

ccggcctacg ctcgccacta caagctggag tttctcgagc ccctgttgtg gtggtacttt      420

cggacgctgc acaaccgggc tcacctgaac ctcgccacgt ctcgcgcgac gctgcgagag      480

ctggagcgcc aggggtttca gaatctggag ctctgggagc gcggcgtgga cgtggagctg      540

ttccgaaatg ctccgtacag cgaggagatg cgccgccgcc tggcgcccga agcgaagccg      600

ggcgatcgcg tcctgctgta cgtggggcgc ttggcgtcgg aaaagaatat cgagcgcatg      660

cgcccggtcc tggacgccat cccggatctg cacctcgcca tcgtcggcga cggcccgcac      720

cgccctgaac tcgagcgcgt gttcgccggg acgcggaccc acttcaccgg atacctccat      780

ggggaggagt tggcgcaggc gtatcgcgcc gcggacgcct tcttgtttcc gtcgaccact      840

gagacgctcg ggctggtctt gtttgaggcg atggcggccg gccttcccat cgtggcggcg      900

gacagcccgc ccacgcgcga ggtcctcgag gacggccggg cgggattcat cttcgatccc      960

gattcgaccg agtccctcat cgcgaccgtc gatctcgtga tgcgggacga agcgaggcga     1020

gaggcggtca gacagcgcgg cttggccatc gcggagcagc tggattggga ggggccgagc     1080

aagcaactgc tcggtcacta cgagcgagtc ttgcagtcgt tcagcgtcgt cgcgggcgcc     1140

gtcaccggca cccgctga                                                   1158


<210>   3
<211>   382
<212>   PRT
<213>   Synechococcus sp. WH 7803

<400>   3
Met Lys Ile Ala Phe Phe Thr Glu Thr Phe Leu Pro Lys Val Asp Gly 
                5                   10                  15      

Ile Val Thr Arg Leu Thr Lys Thr Val Lys His Leu Val Asp Ala Gly 
            20                  25                  30          

Asp Glu Val Ile Val Phe Cys Pro Glu Gly Cys Pro Glu Glu Tyr Met 
        35                  40                  45              

Gly Ala Arg Leu Ile Gly Val Pro Ala Met Pro Leu Pro Leu Tyr Pro 
    50                  55                  60                  

Glu Leu Lys Leu Ala Leu Pro Arg Pro Ala Val Ser Glu Ala Ile Asp 
65                  70                  75                  80  

Ser Phe Gln Pro Asp Leu Ile His Val Val Asn Pro Ala Val Leu Gly 
                85                  90                  95      

Leu Gly Gly Ile Trp Leu Ala Lys Ala Lys Ser Ile Pro Leu Val Ala 
            100                 105                 110         

Ser Tyr His Thr His Leu Pro Lys Tyr Leu Glu His Tyr Gly Met Gly 
        115                 120                 125             

Met Leu Glu Pro Leu Leu Trp Glu Leu Leu Lys Ala Ala His Asn Gln 
    130                 135                 140                 

Ala Leu Leu Asn Leu Cys Thr Ser Thr Ala Met Val Gln Glu Leu Ser 
145                 150                 155                 160 

Asp Lys Gly Ile Gln His Thr Asp Leu Trp Gln Arg Gly Val Asp Thr 
                165                 170                 175     

Glu Leu Phe Arg Pro Asp Leu Arg Ser Ala Glu Leu Arg Gln Arg Leu 
            180                 185                 190         

Leu Gly Arg His Asp Asp Arg Gly Ala Leu Leu Leu Tyr Val Gly Arg 
        195                 200                 205             

Leu Ser Ala Glu Lys Gln Ile Glu Arg Ile Lys Pro Val Leu Glu Ala 
    210                 215                 220                 

Leu Pro Asp Ala Arg Leu Ala Leu Val Gly Asp Gly Pro His Arg Gln 
225                 230                 235                 240 

Gln Leu Glu Lys His Phe Glu Gly Thr Ala Thr Thr Phe Val Gly Tyr 
                245                 250                 255     

Leu Ala Gly Glu Glu Leu Ala Gly Ala Tyr Ala Ser Gly Asp Ala Phe 
            260                 265                 270         

Leu Phe Pro Ser Ser Thr Glu Thr Leu Gly Leu Val Leu Leu Glu Ala 
        275                 280                 285             

Met Ala Ala Gly Cys Pro Val Val Gly Ala Asn Arg Gly Gly Ile Pro 
    290                 295                 300                 

Asp Ile Ile Ser Asp Gly Val Asn Gly Cys Leu Tyr Glu Pro Asp Gly 
305                 310                 315                 320 

Ala Asp Gly Gly Ala Ala Ser Leu Ile Ala Ala Thr Gln Arg Leu Leu 
                325                 330                 335     

Gly Asn Asp Val Glu Arg Gln Ala Leu Arg Asn Ala Ala Arg Ser Glu 
            340                 345                 350         

Ala Glu Arg Trp Gly Trp Ala Gly Ala Thr Glu Gln Leu Arg Gly Tyr 
        355                 360                 365             

Tyr Arg Gln Val Leu Lys Gln Pro Gln Leu Asn Ala Ala Ala 
    370                 375                 380         

<210>   4
<211>   375
<212>   PRT
<213>   Synechococcus sp. CC9311

<400>   4
Met Lys Ile Ala Phe Phe Thr Glu Thr Phe Leu Pro Lys Val Asp Gly 
                5                   10                  15      

Ile Val Thr Arg Leu Thr Lys Thr Val Lys His Leu Val Asp Ala Gly 
            20                  25                  30          

Asp Glu Val Val Val Phe Cys Pro Glu Gly Ala Pro Ser His Tyr Met 
        35                  40                  45              

Gly Ala Lys Val Val Gly Val Pro Ala Met Pro Leu Pro Leu Tyr Pro 
    50                  55                  60                  

Glu Leu Lys Leu Ala Leu Pro Arg Pro Ala Val Ser Glu Ala Ile Asp 
65                  70                  75                  80  

Ala Phe Gln Pro Asp Leu Ile His Val Val Asn Pro Ala Val Leu Gly 
                85                  90                  95      

Leu Gly Gly Ile Trp Leu Ala Lys Thr Lys Ser Ile Pro Leu Ile Ala 
            100                 105                 110         

Ser Tyr His Thr His Leu Pro Lys Tyr Leu Glu His Tyr Gly Met Gly 
        115                 120                 125             

Met Leu Glu Pro Leu Leu Trp Glu Leu Leu Lys Ala Ala His Asn Gln 
    130                 135                 140                 

Ala Val Leu Asn Leu Cys Thr Ser Thr Ala Met Val Gln Glu Leu Ser 
145                 150                 155                 160 

Asp Lys Gly Ile Gln His Thr Ala Leu Trp Gln Arg Gly Val Asp Thr 
                165                 170                 175     

Glu Leu Phe Arg Pro Glu Leu Arg Ser Pro Glu Leu Arg Gln Arg Leu 
            180                 185                 190         

Leu Gly Glu Tyr Asp Asp Arg Gly Ala Leu Leu Leu Tyr Val Gly Arg 
        195                 200                 205             

Leu Ser Ala Glu Lys Gln Ile Glu Arg Ile Arg Pro Val Leu Glu Ala 
    210                 215                 220                 

Leu Pro Asp Thr Arg Leu Ala Leu Val Gly Asp Gly Pro His Arg Gln 
225                 230                 235                 240 

Gln Leu Glu Lys His Phe Glu Gly Thr Ala Thr Thr Phe Val Gly Tyr 
                245                 250                 255     

Leu Ala Gly Glu Glu Leu Ala Gly Ala Tyr Ala Ser Gly Asp Ala Phe 
            260                 265                 270         

Leu Phe Pro Ser Ser Thr Glu Thr Leu Gly Leu Val Leu Leu Glu Ala 
        275                 280                 285             

Met Ala Ala Gly Cys Pro Val Val Gly Ala Asn Arg Gly Gly Ile Pro 
    290                 295                 300                 

Asp Ile Ile Ser Asp Gly Val Asn Gly Cys Leu Tyr Glu Pro Asp Gly 
305                 310                 315                 320 

Ala Asp Ala Gly Ala Gly Ser Leu Ile Glu Ala Thr Gly Lys Leu Leu 
                325                 330                 335     

Gly Asn Asp Leu Glu Arg Gln Ala Leu Arg Asn Ala Ala Arg Ser Glu 
            340                 345                 350         

Ala Glu Arg Trp Gly Trp Ala Gly Ala Thr Glu Gln Leu Arg Gly Tyr 
        355                 360                 365             

Tyr Arg Gln Val Leu Ser Ser 
    370                 375 

<210>   5
<211>   368
<212>   PRT
<213>   Synechococcus sp. WH 5701

<400>   5
Met Lys Ile Ala Leu Phe Thr Glu Thr Phe Leu Pro Lys Val Asp Gly 
                5                   10                  15      

Ile Val Thr Arg Leu Thr Lys Thr Val Glu His Leu Val Arg Ala Gly 
            20                  25                  30          

Asp Glu Val Leu Leu Phe Cys Pro Glu Gly Ala Pro Ser Leu Tyr Met 
        35                  40                  45              

Gly Ala Arg Val Ile Gly Val Pro Ala Leu Pro Leu Pro Leu Tyr Pro 
    50                  55                  60                  

Glu Leu Lys Leu Ala Leu Pro Arg Pro Ala Val Ala Glu Ala Leu Glu 
65                  70                  75                  80  

Ala Phe Gln Pro Asp Val Val His Val Val Asn Pro Ala Val Leu Gly 
                85                  90                  95      

Leu Gly Gly Ile Trp Met Ala Arg Thr Arg Gln Ile Pro Leu Val Ala 
            100                 105                 110         

Ser Tyr His Thr His Leu Pro Lys Tyr Leu Glu His Tyr Gly Met Gly 
        115                 120                 125             

Val Leu Glu Pro Leu Leu Trp Glu Leu Leu Lys Ala Ala His Asn Gln 
    130                 135                 140                 

Ala Val Leu Asn Leu Cys Thr Ser Ser Val Met Val Glu Glu Leu Ala 
145                 150                 155                 160 

Gln Arg Gly Ile Gln His Thr Ala Leu Trp Gln Arg Gly Val Asp Thr 
                165                 170                 175     

Glu Met Phe Arg Pro Glu Leu Arg Ser Asp Ala Met Arg Arg Arg Leu 
            180                 185                 190         

Met Gly Arg His Pro Asp Ser Asp Ser Leu Leu Leu Tyr Val Gly Arg 
        195                 200                 205             

Leu Ser Ala Glu Lys Gln Ile Glu Arg Ile Arg Pro Val Leu Asp Ala 
    210                 215                 220                 

Leu Pro Gln Ala Arg Leu Ala Leu Val Gly Asp Gly Pro His Arg Ala 
225                 230                 235                 240 

Gln Leu Glu Lys Val Phe Glu Gly Thr Ala Thr Thr Phe Val Gly Tyr 
                245                 250                 255     

Leu Gly Gly Glu Glu Leu Ala Gly Ala Phe Ala Ser Ala Asp Ala Phe 
            260                 265                 270         

Leu Phe Pro Ser Ser Thr Glu Thr Leu Gly Leu Val Leu Leu Glu Ala 
        275                 280                 285             

Met Ala Ala Gly Cys Pro Val Val Gly Ala Asn Arg Gly Gly Ile Pro 
    290                 295                 300                 

Asp Ile Val Thr Asp Gly Val Asn Gly Cys Leu Tyr Asp Pro Asp Asp 
305                 310                 315                 320 

Asp Ala Ser Leu Thr Ala Ala Thr Leu Arg Leu Leu Ala Ser Pro Glu 
                325                 330                 335     

Arg Arg Glu Gln Leu Arg Leu Ala Ala Arg His Glu Ala Glu Arg Trp 
            340                 345                 350         

Gly Trp Ala Gly Ala Thr Ala Gln Leu Arg Arg Phe Tyr Arg Asp Val 
        355                 360                 365             

<210>   6
<211>   374
<212>   PRT
<213>   Synechococcus sp. RS9917

<400>   6
Met Lys Ile Ala Phe Phe Thr Glu Thr Phe Leu Pro Lys Val Asp Gly 
                5                   10                  15      

Ile Val Thr Arg Leu Thr Lys Thr Val Lys His Leu Val Glu Ala Gly 
            20                  25                  30          

Asp Glu Val Leu Val Phe Cys Pro Glu Gly Ala Pro Ser Glu Tyr Met 
        35                  40                  45              

Gly Ala Gly Val Ile Gly Val Pro Ala Met Pro Leu Pro Leu Tyr Pro 
    50                  55                  60                  

Glu Leu Lys Leu Ala Leu Pro Arg Pro Ala Val Ser Glu Ala Ile Asp 
65                  70                  75                  80  

Ala Phe Gln Pro Asp Leu Val His Val Val Asn Pro Ala Val Leu Gly 
                85                  90                  95      

Leu Gly Gly Ile Trp Leu Ala Lys Asn Lys Ala Ile Pro Leu Ile Ala 
            100                 105                 110         

Ser Tyr His Thr His Leu Pro Lys Tyr Leu Glu His Tyr Gly Met Gly 
        115                 120                 125             

Met Leu Glu Pro Leu Leu Trp Glu Leu Leu Lys Ala Ala His Asn Gln 
    130                 135                 140                 

Ala Glu Leu Asn Leu Cys Thr Ser Thr Ala Met Val Lys Glu Leu Ser 
145                 150                 155                 160 

Glu Lys Gly Ile Gln His Thr Ala Leu Trp Gln Arg Gly Val Asp Thr 
                165                 170                 175     

Glu Leu Phe Arg Pro Glu Leu Arg Ser Asp Ala Met Arg Gln Arg Leu 
            180                 185                 190         

Leu Gly Ala His Asp Asp Arg Cys Ala Leu Leu Leu Tyr Val Gly Arg 
        195                 200                 205             

Leu Ser Ala Glu Lys Gln Ile Glu Arg Ile Arg Pro Val Leu Glu Ala 
    210                 215                 220                 

Leu Pro Asp Thr Arg Leu Ala Leu Val Gly Asp Gly Pro His Arg Gln 
225                 230                 235                 240 

Gln Leu Glu Arg His Phe Glu Gly Thr Ala Thr Thr Phe Val Gly Tyr 
                245                 250                 255     

Leu Ala Gly Glu Glu Leu Ala Ser Ala Tyr Ala Ser Gly Asp Ala Phe 
            260                 265                 270         

Leu Phe Pro Ser Ser Thr Glu Thr Leu Gly Leu Val Leu Leu Glu Ala 
        275                 280                 285             

Met Ala Ala Gly Cys Pro Val Val Gly Ala Asn Arg Gly Gly Ile Pro 
    290                 295                 300                 

Asp Ile Ile Ser Asp Gly Leu Asn Gly Cys Leu Tyr Glu Pro Asp Gly 
305                 310                 315                 320 

Ala Asp Gly Gly Ala Ala Ser Leu Ile Gln Ala Thr Gln Arg Leu Leu 
                325                 330                 335     

Gly Asn Asp Leu Glu Arg Gln Ala Leu Arg Arg Ala Ala Arg Thr Glu 
            340                 345                 350         

Ala Glu Arg Trp Gly Trp Ala Gly Ala Thr Glu Gln Leu Arg Thr Tyr 
        355                 360                 365             

Tyr Arg Asn Val Leu Lys 
    370                 

<210>   7
<211>   374
<212>   PRT
<213>   Synechococcus sp. RS9916

<400>   7
Met Lys Val Ala Phe Phe Thr Glu Thr Phe Leu Pro Lys Val Asp Gly 
                5                   10                  15      

Ile Val Thr Arg Leu Thr Lys Thr Val Lys His Leu Val Asp Ala Gly 
            20                  25                  30          

Asp Glu Val Met Val Phe Cys Pro Glu Gly Cys Pro Asp Asn Tyr Met 
        35                  40                  45              

Gly Ala Lys Leu Val Gly Val Pro Ala Met Pro Leu Pro Leu Tyr Pro 
    50                  55                  60                  

Glu Leu Lys Leu Ala Leu Pro Arg Pro Ala Val Ser Asp Ala Ile Asp 
65                  70                  75                  80  

Ala Phe Gln Pro Asp Leu Ile His Val Val Asn Pro Ala Val Leu Gly 
                85                  90                  95      

Leu Gly Gly Ile Trp Leu Ala Lys Thr Lys Gly Ile Pro Leu Val Ala 
            100                 105                 110         

Ser Tyr His Thr His Leu Pro Lys Tyr Leu Glu His Tyr Gly Met Gly 
        115                 120                 125             

Met Leu Glu Pro Leu Leu Trp Glu Met Leu Lys Ala Ala His Asn Gln 
    130                 135                 140                 

Ala Leu Leu Asn Leu Cys Thr Ser Thr Ala Met Val Lys Glu Leu Ser 
145                 150                 155                 160 

Glu Lys Gly Ile Gln His Thr Asp Leu Trp Gln Arg Gly Val Asp Thr 
                165                 170                 175     

Asp Leu Phe Arg Pro Glu Leu Arg Ser Glu Thr Met Arg Gln Arg Leu 
            180                 185                 190         

Leu Gly Arg His Asp Asp Arg Gly Ser Leu Leu Leu Tyr Val Gly Arg 
        195                 200                 205             

Leu Ser Ala Glu Lys Gln Ile Glu Arg Ile Lys Pro Val Leu Glu Ala 
    210                 215                 220                 

Leu Pro Asp Thr Arg Leu Ala Leu Val Gly Asp Gly Pro His Arg Gln 
225                 230                 235                 240 

Gln Leu Glu Lys His Phe Glu Gly Thr Ala Thr Thr Phe Val Gly Tyr 
                245                 250                 255     

Leu Ala Gly Glu Glu Leu Ala Ser Ala Tyr Ala Ser Gly Asp Ala Phe 
            260                 265                 270         

Leu Phe Pro Ser Ser Thr Glu Thr Leu Gly Leu Val Leu Leu Glu Ala 
        275                 280                 285             

Met Ala Ala Gly Cys Pro Val Val Gly Ala Asn Arg Gly Gly Ile Pro 
    290                 295                 300                 

Asp Ile Ile Ser Asp Gly Ile Asn Gly Cys Leu Tyr Glu Pro Asp Gly 
305                 310                 315                 320 

Ala Asp Glu Gly Ala Ala Ser Leu Ile Asn Ala Ala Arg Lys Leu Leu 
                325                 330                 335     

Gly Asn Asp Ile Glu Arg Gln Gly Leu Arg Thr Ala Ala Arg Ser Glu 
            340                 345                 350         

Ala Glu Arg Trp Gly Trp Ala Gly Ala Thr Glu Gln Leu Arg Gly Tyr 
        355                 360                 365             

Tyr Arg Gln Val Leu Gln 
    370                 

<210>   8
<211>   385
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1

<400>   8
Met Ser Met Arg Ile Ala Met Phe Thr Glu Thr Phe Leu Pro Ser Thr 
                5                   10                  15      

Asp Gly Ile Val Thr Arg Leu Cys Ala Thr Leu Lys Tyr Leu Glu Arg 
            20                  25                  30          

Glu Gly His Glu Val Leu Leu Phe Ala Pro Ser Gly Ser Pro Glu Thr 
        35                  40                  45              

Tyr Ala Ser Ala Thr Ile Val Gly Ile Pro Ala Met Pro Phe Ile Leu 
    50                  55                  60                  

Tyr Pro Glu Lys Arg Tyr Ser Leu Pro Leu Pro Arg Ile Gly Lys His 
65                  70                  75                  80  

Leu Arg Ala Phe Arg Pro Asp Leu Ile His Val Val Asn Pro Ala Phe 
                85                  90                  95      

Leu Gly Ile Gly Gly Ile Tyr Tyr Ala Trp Lys Ser His Leu Pro Leu 
            100                 105                 110         

Val Ala Ser Tyr His Thr Asn Val Pro Ala Tyr Ala Arg His Tyr Lys 
        115                 120                 125             

Leu Glu Phe Leu Glu Pro Leu Leu Trp Trp Tyr Phe Arg Thr Leu His 
    130                 135                 140                 

Asn Arg Ala His Leu Asn Leu Ala Thr Ser Arg Ala Thr Leu Arg Glu 
145                 150                 155                 160 

Leu Glu Arg Gln Gly Phe Gln Asn Leu Glu Leu Trp Glu Arg Gly Val 
                165                 170                 175     

Asp Val Glu Leu Phe Arg Asn Ala Pro Tyr Ser Glu Glu Met Arg Arg 
            180                 185                 190         

Arg Leu Ala Pro Glu Ala Lys Pro Gly Asp Arg Val Leu Leu Tyr Val 
        195                 200                 205             

Gly Arg Leu Ala Ser Glu Lys Asn Ile Glu Arg Met Arg Pro Val Leu 
    210                 215                 220                 

Asp Ala Ile Pro Asp Leu His Leu Ala Ile Val Gly Asp Gly Pro His 
225                 230                 235                 240 

Arg Pro Glu Leu Glu Arg Val Phe Ala Gly Thr Arg Thr His Phe Thr 
                245                 250                 255     

Gly Tyr Leu His Gly Glu Glu Leu Ala Gln Ala Tyr Arg Ala Ala Asp 
            260                 265                 270         

Ala Phe Leu Phe Pro Ser Thr Thr Glu Thr Leu Gly Leu Val Leu Phe 
        275                 280                 285             

Glu Ala Met Ala Ala Gly Leu Pro Ile Val Ala Ala Asp Ser Pro Pro 
    290                 295                 300                 

Thr Arg Glu Val Leu Glu Asp Gly Arg Ala Gly Phe Ile Phe Asp Pro 
305                 310                 315                 320 

Asp Ser Thr Glu Ser Leu Ile Ala Thr Val Asp Leu Val Met Arg Asp 
                325                 330                 335     

Glu Ala Arg Arg Glu Ala Val Arg Gln Arg Gly Leu Ala Ile Ala Glu 
            340                 345                 350         

Gln Leu Asp Trp Glu Gly Pro Ser Lys Gln Leu Leu Gly His Tyr Glu 
        355                 360                 365             

Arg Val Leu Asn Ser Phe Ser Val Val Ala Gly Ala Val Thr Gly Thr 
    370                 375                 380                 

Arg 
385 

<210>   9
<211>   385
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1

<400>   9
Met Ser Met Arg Ile Ala Met Phe Thr Glu Thr Phe Leu Pro Ser Thr 
                5                   10                  15      

Asp Gly Ile Val Thr Arg Leu Cys Ala Thr Leu Lys Tyr Leu Glu Arg 
            20                  25                  30          

Glu Gly His Glu Val Leu Leu Phe Ala Pro Ser Gly Ser Pro Glu Thr 
        35                  40                  45              

Tyr Ala Ser Ala Thr Ile Val Gly Ile Pro Ala Met Pro Phe Ile Leu 
    50                  55                  60                  

Tyr Pro Glu Lys Arg Tyr Ser Leu Pro Leu Pro Arg Ile Gly Lys His 
65                  70                  75                  80  

Leu Arg Ala Phe Arg Pro Asp Leu Ile His Val Val Asn Pro Ala Phe 
                85                  90                  95      

Leu Gly Ile Gly Gly Ile Tyr Tyr Ala Trp Lys Ser His Leu Pro Leu 
            100                 105                 110         

Val Ala Ser Tyr His Thr Asn Val Pro Ala Tyr Ala Arg His Tyr Lys 
        115                 120                 125             

Leu Glu Phe Leu Glu Pro Leu Leu Trp Trp Tyr Phe Arg Thr Leu His 
    130                 135                 140                 

Asn Arg Ala His Leu Asn Leu Ala Thr Ser Arg Ala Thr Leu Arg Glu 
145                 150                 155                 160 

Leu Glu Arg Gln Gly Phe Gln Asn Leu Glu Leu Trp Glu Arg Gly Val 
                165                 170                 175     

Asp Val Glu Leu Phe Arg Asn Ala Pro Tyr Ser Glu Glu Met Arg Arg 
            180                 185                 190         

Arg Leu Ala Pro Glu Ala Lys Pro Gly Asp Arg Val Leu Leu Tyr Val 
        195                 200                 205             

Gly Arg Leu Ala Ser Glu Lys Asn Ile Glu Arg Met Arg Pro Val Leu 
    210                 215                 220                 

Asp Ala Ile Pro Asp Leu His Leu Ala Ile Val Gly Asp Gly Pro His 
225                 230                 235                 240 

Arg Pro Glu Leu Glu Arg Val Phe Ala Gly Thr Arg Thr His Phe Thr 
                245                 250                 255     

Gly Tyr Leu His Gly Glu Glu Leu Ala Gln Ala Tyr Arg Ala Ala Asp 
            260                 265                 270         

Ala Phe Leu Phe Pro Ser Thr Thr Glu Thr Leu Gly Leu Val Leu Phe 
        275                 280                 285             

Glu Ala Met Ala Ala Gly Leu Pro Ile Val Ala Ala Asp Ser Pro Pro 
    290                 295                 300                 

Thr Arg Glu Val Leu Glu Asp Gly Arg Ala Gly Phe Ile Phe Asp Pro 
305                 310                 315                 320 

Asp Ser Thr Glu Ser Leu Ile Ala Thr Val Asp Leu Val Met Arg Asp 
                325                 330                 335     

Glu Ala Arg Arg Glu Ala Val Arg Gln Arg Gly Leu Ala Ile Ala Glu 
            340                 345                 350         

Gln Leu Asp Trp Glu Gly Pro Ser Lys Gln Leu Leu Gly His Tyr Glu 
        355                 360                 365             

Arg Val Leu Gln Ser Phe Ser Ile Val Ala Gly Ala Val Thr Gly Thr 
    370                 375                 380                 

Arg 
385 

<210>   10
<211>   385
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1

<400>   10
Met Ser Met Arg Ile Ala Met Phe Thr Glu Thr Phe Leu Pro Ser Thr 
                5                   10                  15      

Asp Gly Ile Val Thr Arg Leu Cys Ala Thr Leu Lys Tyr Leu Glu Arg 
            20                  25                  30          

Glu Gly His Glu Val Leu Leu Phe Ala Pro Ser Gly Ser Pro Glu Thr 
        35                  40                  45              

Tyr Ala Ser Ala Thr Ile Val Gly Ile Pro Ala Met Pro Phe Ile Leu 
    50                  55                  60                  

Tyr Pro Glu Lys Arg Tyr Ser Leu Pro Ile Pro Arg Ile Gly Lys His 
65                  70                  75                  80  

Leu Arg Ala Phe Arg Pro Asp Leu Ile His Val Val Asn Pro Ala Phe 
                85                  90                  95      

Leu Gly Ile Gly Gly Ile Tyr Tyr Ala Trp Lys Ser His Leu Pro Leu 
            100                 105                 110         

Val Ala Ser Tyr His Thr Asn Val Pro Ala Tyr Ala Arg His Tyr Lys 
        115                 120                 125             

Leu Glu Phe Leu Glu Pro Leu Leu Trp Trp Tyr Phe Arg Thr Leu His 
    130                 135                 140                 

Asn Arg Ala His Leu Asn Leu Ala Thr Ser Arg Ala Thr Leu Arg Glu 
145                 150                 155                 160 

Leu Glu Arg Gln Gly Phe Gln Asn Leu Glu Leu Trp Glu Arg Gly Val 
                165                 170                 175     

Asp Val Glu Leu Phe Arg Asn Ala Pro Tyr Ser Glu Glu Met Arg Arg 
            180                 185                 190         

Arg Leu Ala Pro Glu Ala Lys Pro Gly Asp Arg Val Leu Leu Tyr Val 
        195                 200                 205             

Gly Arg Leu Ala Ser Glu Lys Asn Ile Glu Arg Met Arg Pro Val Leu 
    210                 215                 220                 

Asp Ala Ile Pro Asp Leu His Leu Ala Ile Val Gly Asp Gly Pro His 
225                 230                 235                 240 

Arg Pro Glu Leu Glu Arg Val Phe Ala Gly Thr Arg Thr His Phe Thr 
                245                 250                 255     

Gly Tyr Leu His Gly Glu Glu Leu Ala Gln Ala Tyr Arg Ala Ala Asp 
            260                 265                 270         

Ala Phe Leu Phe Pro Ser Thr Thr Glu Thr Leu Gly Leu Val Leu Phe 
        275                 280                 285             

Glu Ala Met Ala Ala Gly Leu Pro Ile Val Ala Ala Asp Ser Pro Pro 
    290                 295                 300                 

Thr Arg Glu Val Leu Glu Asp Gly Arg Ala Gly Phe Ile Phe Asp Pro 
305                 310                 315                 320 

Asp Ser Thr Glu Ser Leu Ile Ala Thr Val Asp Leu Val Met Arg Asp 
                325                 330                 335     

Glu Ala Arg Arg Glu Ala Val Arg Gln Arg Gly Leu Ala Ile Ala Glu 
            340                 345                 350         

Gln Leu Asp Trp Glu Gly Pro Ser Lys Gln Leu Leu Gly His Tyr Glu 
        355                 360                 365             

Arg Val Leu Gln Ser Phe Ser Val Val Ala Gly Ala Val Thr Gly Thr 
    370                 375                 380                 

Arg 
385 

<210>   11
<211>   385
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1

<400>   11
Met Ser Met Arg Ile Ala Met Phe Thr Glu Thr Phe Leu Pro Ser Thr 
                5                   10                  15      

Asp Gly Ile Val Thr Arg Leu Cys Ala Thr Leu Lys Tyr Leu Glu Arg 
            20                  25                  30          

Glu Gly His Glu Val Leu Leu Phe Ala Pro Ser Gly Ser Pro Glu Thr 
        35                  40                  45              

Tyr Ala Ser Ala Thr Ile Val Gly Ile Pro Ala Met Pro Phe Ile Leu 
    50                  55                  60                  

Tyr Pro Glu Lys Arg Tyr Ser Leu Pro Leu Pro Arg Ile Gly Lys His 
65                  70                  75                  80  

Leu Arg Ala Phe Arg Pro Asp Leu Ile His Val Val Asn Pro Ala Phe 
                85                  90                  95      

Leu Gly Ile Gly Gly Ile Tyr Tyr Ala Trp Lys Ser His Leu Pro Leu 
            100                 105                 110         

Val Ala Ser Tyr His Thr Asn Val Pro Ala Tyr Ala Arg His Tyr Lys 
        115                 120                 125             

Leu Glu Phe Leu Glu Pro Leu Leu Trp Trp Tyr Phe Arg Thr Leu His 
    130                 135                 140                 

Asn Arg Ala His Leu Asn Leu Ala Thr Ser Arg Ala Thr Leu Arg Glu 
145                 150                 155                 160 

Leu Glu Arg Gln Gly Phe Gln Asn Leu Glu Leu Trp Glu Arg Gly Val 
                165                 170                 175     

Asp Val Glu Leu Phe Arg Asn Ala Pro Tyr Ser Glu Glu Met Arg Arg 
            180                 185                 190         

Arg Leu Ala Pro Glu Ala Lys Pro Gly Asp Arg Val Leu Leu Tyr Val 
        195                 200                 205             

Gly Arg Leu Ala Ser Glu Lys Asn Ile Glu Arg Met Arg Pro Val Leu 
    210                 215                 220                 

Asp Ala Ile Pro Asp Leu His Leu Ala Ile Val Gly Asp Gly Pro His 
225                 230                 235                 240 

Arg Pro Glu Leu Glu Arg Val Phe Ala Gly Thr Arg Thr His Phe Thr 
                245                 250                 255     

Gly Tyr Leu His Gly Glu Glu Leu Ala Gln Ala Tyr Arg Ala Ala Asp 
            260                 265                 270         

Ala Phe Leu Phe Pro Ser Thr Thr Glu Thr Leu Gly Leu Val Leu Phe 
        275                 280                 285             

Glu Ala Met Ala Ala Gly Leu Pro Ile Val Ala Ala Asp Ser Pro Pro 
    290                 295                 300                 

Thr Arg Glu Val Leu Glu Asp Gly Arg Ala Gly Phe Ile Phe Asp Pro 
305                 310                 315                 320 

Asp Ser Thr Glu Ser Leu Leu Ala Thr Val Asp Leu Val Met Arg Asp 
                325                 330                 335     

Glu Ala Arg Arg Glu Ala Val Arg Gln Arg Gly Leu Ala Ile Ala Glu 
            340                 345                 350         

Gln Leu Asp Trp Glu Gly Pro Ser Lys Gln Leu Leu Gly His Tyr Glu 
        355                 360                 365             

Arg Val Leu Gln Ser Phe Ser Val Val Ala Gly Ala Val Thr Gly Thr 
    370                 375                 380                 

Arg 
385 

<210>   12
<211>   385
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 1

<400>   12
Met Ser Met Arg Ile Ala Met Phe Thr Glu Thr Phe Leu Pro Ser Thr 
                5                   10                  15      

Asp Gly Ile Val Thr Arg Leu Cys Ala Thr Leu Lys Tyr Leu Glu Arg 
            20                  25                  30          

Glu Gly His Glu Val Leu Leu Phe Ala Pro Ser Gly Ser Pro Glu Thr 
        35                  40                  45              

Tyr Ala Ser Ala Thr Ile Val Gly Ile Pro Ala Met Pro Phe Ile Leu 
    50                  55                  60                  

Tyr Pro Glu Lys Arg Tyr Ser Leu Pro Leu Pro Arg Ile Gly Lys His 
65                  70                  75                  80  

Leu Arg Ala Phe Arg Pro Asp Leu Ile His Val Val Asn Pro Ala Phe 
                85                  90                  95      

Leu Gly Ile Gly Gly Ile Tyr Tyr Ala Trp Lys Ser His Leu Pro Leu 
            100                 105                 110         

Val Ala Ser Tyr His Thr Asn Val Pro Ala Tyr Ala Arg His Tyr Lys 
        115                 120                 125             

Leu Glu Phe Leu Glu Pro Leu Leu Trp Trp Tyr Phe Arg Thr Leu His 
    130                 135                 140                 

Asn Arg Ala His Leu Asn Leu Ala Thr Ser Arg Ala Thr Leu Arg Glu 
145                 150                 155                 160 

Leu Glu Arg Gln Gly Phe Gln Asn Leu Glu Leu Trp Glu Arg Gly Val 
                165                 170                 175     

Asp Val Glu Leu Phe Arg Asn Ala Pro Tyr Ser Asp Glu Met Arg Arg 
            180                 185                 190         

Arg Leu Ala Pro Glu Ala Lys Pro Gly Asp Arg Val Leu Leu Tyr Val 
        195                 200                 205             

Gly Arg Leu Ala Ser Glu Lys Asn Ile Glu Arg Met Arg Pro Val Leu 
    210                 215                 220                 

Asp Ala Ile Pro Asp Leu His Leu Ala Ile Val Gly Asp Gly Pro His 
225                 230                 235                 240 

Arg Pro Glu Leu Glu Arg Val Phe Ala Gly Thr Arg Thr His Phe Thr 
                245                 250                 255     

Gly Tyr Leu His Gly Glu Glu Leu Ala Gln Ala Tyr Arg Ala Ala Asp 
            260                 265                 270         

Ala Phe Leu Phe Pro Ser Thr Thr Glu Thr Leu Gly Leu Val Leu Phe 
        275                 280                 285             

Glu Ala Met Ala Ala Gly Leu Pro Ile Val Ala Ala Asp Ser Pro Pro 
    290                 295                 300                 

Thr Arg Glu Val Leu Glu Asp Gly Arg Ala Gly Phe Ile Phe Asp Pro 
305                 310                 315                 320 

Asp Ser Thr Glu Ser Leu Ile Ala Thr Val Asp Leu Val Met Arg Asp 
                325                 330                 335     

Glu Ala Arg Arg Glu Ala Val Arg Gln Arg Gly Leu Ala Ile Ala Glu 
            340                 345                 350         

Gln Leu Asp Trp Glu Gly Pro Ser Lys Gln Leu Leu Gly His Tyr Glu 
        355                 360                 365             

Arg Val Leu Gln Ser Phe Ser Val Val Ala Gly Ala Val Thr Gly Thr 
    370                 375                 380                 

Arg 
385 

<210>   13
<211>   1158
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 2

<400>   13
gtgagcatga ggatcgcgat gtttacggag acgtttctgc cgtcgaccga cgggatcgtc       60

accaggctct gtgcaacgct gaaatacttg gagcgcgagg gccacgaggt gctgctgttc      120

gccccgtcgg gatcgccgga gacctacgct tccgcaacca tcgtcgggat ccctgcgatg      180

ccgttcatcc tgtatccaga aaagcgatac tcgttgccgc tgccgcgcat cggcaaacat      240

ctgcgggcgt ttcggccgga tctcatccac gtggtgaatc cggcgttcct cggcatcggg      300

ggcatctact acgcgtggaa gtctcatctg ccgctggtgg cctcgtatca caccaacgtg      360

ccggcctacg ctcgccacta caagctggag tttctcgagc ccctgttgtg gtggtacttt      420

cggacgctgc acaaccgggc tcacctgaac ctcgccacgt ctcgcgcgac gctgcgagag      480

ctggagcgcc aggggtttca gaatctggag ctctgggagc gcggcgtgga cgtggagctg      540

ttccgaaatg ctccgtacag cgaggagatg cgccgccgcc tggcgcccga agcgaagccg      600

ggcgatcgcg tcctgctgta cgtggggcgc ttggcgtcgg aaaagaatat cgagcgcatg      660

cgcccggtcc tggacgccat cccggatctg cacctcgcca tcgtcggcga cggcccgcac      720

cgccctgaac tcgagcgcgt gttcgccggg acgcggaccc acttcaccgg atacctccat      780

ggggaggagt tggcgcaggc gtatcgcgcc gcggacgcct tcttgtttcc gtcgaccact      840

gagacgctcg ggctggtctt gtttgaggcg atggcggccg gccttcccat cgtggcggcg      900

gacagcccgc ccacgcgcga ggtcctcgag gacggccggg cgggattcat cttcgatccc      960

gattcgaccg agtccctcat cgcgaccgtc gatctcgtga tgcgggacga agcgaggcga     1020

gaggcggtca gacagcgcgg cttggccatc gcggagcagc tggattggga ggggccgagc     1080

aagcaactgc tcggtcacta cgagcgagtc ttgaattcgt tcagcgtcgt cgcgggcgcc     1140

gtcaccggca cccgctga                                                   1158


<210>   14
<211>   1158
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 2

<400>   14
gtgagcatga ggatcgcgat gtttacggag acgtttctgc cgtcgaccga cgggatcgtc       60

accaggctct gtgcaacgct gaaatacttg gagcgcgagg gccacgaggt gctgctgttc      120

gccccgtcgg gatcgccgga gacctacgct tccgcaacca tcgtcgggat ccctgcgatg      180

ccgttcatcc tgtatccaga aaagcgatac tcgttgccgc tgccgcgcat cggcaaacat      240

ctgcgggcgt ttcggccgga tctcatccac gtggtgaatc cggcgttcct cggcatcggg      300

ggcatctact acgcgtggaa gtctcatctg ccgctggtgg cctcgtatca caccaacgtg      360

ccggcctacg ctcgccacta caagctggag tttctcgagc ccctgttgtg gtggtacttt      420

cggacgctgc acaaccgggc tcacctgaac ctcgccacgt ctcgcgcgac gctgcgagag      480

ctggagcgcc aggggtttca gaatctggag ctctgggagc gcggcgtgga cgtggagctg      540

ttccgaaatg ctccgtacag cgaggagatg cgccgccgcc tggcgcccga agcgaagccg      600

ggcgatcgcg tcctgctgta cgtggggcgc ttggcgtcgg aaaagaatat cgagcgcatg      660

cgcccggtcc tggacgccat cccggatctg cacctcgcca tcgtcggcga cggcccgcac      720

cgccctgaac tcgagcgcgt gttcgccggg acgcggaccc acttcaccgg atacctccat      780

ggggaggagt tggcgcaggc gtatcgcgcc gcggacgcct tcttgtttcc gtcgaccact      840

gagacgctcg ggctggtctt gtttgaggcg atggcggccg gccttcccat cgtggcggcg      900

gacagcccgc ccacgcgcga ggtcctcgag gacggccggg cgggattcat cttcgatccc      960

gattcgaccg agtccctcat cgcgaccgtc gatctcgtga tgcgggacga agcgaggcga     1020

gaggcggtca gacagcgcgg cttggccatc gcggagcagc tggattggga ggggccgagc     1080

aagcaactgc tcggtcacta cgagcgagtc ttgcagtcgt tcagcattgt cgcgggcgcc     1140

gtcaccggca cccgctga                                                   1158


<210>   15
<211>   1158
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 2

<400>   15
gtgagcatga ggatcgcgat gtttacggag acgtttctgc cgtcgaccga cgggatcgtc       60

accaggctct gtgcaacgct gaaatacttg gagcgcgagg gccacgaggt gctgctgttc      120

gccccgtcgg gatcgccgga gacctacgct tccgcaacca tcgtcgggat ccctgcgatg      180

ccgttcatcc tgtatccaga aaagcgatac tcgttgccga ttccgcgcat cggcaaacat      240

ctgcgggcgt ttcggccgga tctcatccac gtggtgaatc cggcgttcct cggcatcggg      300

ggcatctact acgcgtggaa gtctcatctg ccgctggtgg cctcgtatca caccaacgtg      360

ccggcctacg ctcgccacta caagctggag tttctcgagc ccctgttgtg gtggtacttt      420

cggacgctgc acaaccgggc tcacctgaac ctcgccacgt ctcgcgcgac gctgcgagag      480

ctggagcgcc aggggtttca gaatctggag ctctgggagc gcggcgtgga cgtggagctg      540

ttccgaaatg ctccgtacag cgaggagatg cgccgccgcc tggcgcccga agcgaagccg      600

ggcgatcgcg tcctgctgta cgtggggcgc ttggcgtcgg aaaagaatat cgagcgcatg      660

cgcccggtcc tggacgccat cccggatctg cacctcgcca tcgtcggcga cggcccgcac      720

cgccctgaac tcgagcgcgt gttcgccggg acgcggaccc acttcaccgg atacctccat      780

ggggaggagt tggcgcaggc gtatcgcgcc gcggacgcct tcttgtttcc gtcgaccact      840

gagacgctcg ggctggtctt gtttgaggcg atggcggccg gccttcccat cgtggcggcg      900

gacagcccgc ccacgcgcga ggtcctcgag gacggccggg cgggattcat cttcgatccc      960

gattcgaccg agtccctcat cgcgaccgtc gatctcgtga tgcgggacga agcgaggcga     1020

gaggcggtca gacagcgcgg cttggccatc gcggagcagc tggattggga ggggccgagc     1080

aagcaactgc tcggtcacta cgagcgagtc ttgcagtcgt tcagcgtcgt cgcgggcgcc     1140

gtcaccggca cccgctga                                                   1158


<210>   16
<211>   1158
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 2

<400>   16
gtgagcatga ggatcgcgat gtttacggag acgtttctgc cgtcgaccga cgggatcgtc       60

accaggctct gtgcaacgct gaaatacttg gagcgcgagg gccacgaggt gctgctgttc      120

gccccgtcgg gatcgccgga gacctacgct tccgcaacca tcgtcgggat ccctgcgatg      180

ccgttcatcc tgtatccaga aaagcgatac tcgttgccgc tgccgcgcat cggcaaacat      240

ctgcgggcgt ttcggccgga tctcatccac gtggtgaatc cggcgttcct cggcatcggg      300

ggcatctact acgcgtggaa gtctcatctg ccgctggtgg cctcgtatca caccaacgtg      360

ccggcctacg ctcgccacta caagctggag tttctcgagc ccctgttgtg gtggtacttt      420

cggacgctgc acaaccgggc tcacctgaac ctcgccacgt ctcgcgcgac gctgcgagag      480

ctggagcgcc aggggtttca gaatctggag ctctgggagc gcggcgtgga cgtggagctg      540

ttccgaaatg ctccgtacag cgaggagatg cgccgccgcc tggcgcccga agcgaagccg      600

ggcgatcgcg tcctgctgta cgtggggcgc ttggcgtcgg aaaagaatat cgagcgcatg      660

cgcccggtcc tggacgccat cccggatctg cacctcgcca tcgtcggcga cggcccgcac      720

cgccctgaac tcgagcgcgt gttcgccggg acgcggaccc acttcaccgg atacctccat      780

ggggaggagt tggcgcaggc gtatcgcgcc gcggacgcct tcttgtttcc gtcgaccact      840

gagacgctcg ggctggtctt gtttgaggcg atggcggccg gccttcccat cgtggcggcg      900

gacagcccgc ccacgcgcga ggtcctcgag gacggccggg cgggattcat cttcgatccc      960

gattcgaccg agtccctctt agcgaccgtc gatctcgtga tgcgggacga agcgaggcga     1020

gaggcggtca gacagcgcgg cttggccatc gcggagcagc tggattggga ggggccgagc     1080

aagcaactgc tcggtcacta cgagcgagtc ttgcagtcgt tcagcgtcgt cgcgggcgcc     1140

gtcaccggca cccgctga                                                   1158


<210>   17
<211>   1158
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 2

<400>   17
gtgagcatga ggatcgcgat gtttacggag acgtttctgc cgtcgaccga cgggatcgtc       60

accaggctct gtgcaacgct gaaatacttg gagcgcgagg gccacgaggt gctgctgttc      120

gccccgtcgg gatcgccgga gacctacgct tccgcaacca tcgtcgggat ccctgcgatg      180

ccgttcatcc tgtatccaga aaagcgatac tcgttgccgc tgccgcgcat cggcaaacat      240

ctgcgggcgt ttcggccgga tctcatccac gtggtgaatc cggcgttcct cggcatcggg      300

ggcatctact acgcgtggaa gtctcatctg ccgctggtgg cctcgtatca caccaacgtg      360

ccggcctacg ctcgccacta caagctggag tttctcgagc ccctgttgtg gtggtacttt      420

cggacgctgc acaaccgggc tcacctgaac ctcgccacgt ctcgcgcgac gctgcgagag      480

ctggagcgcc aggggtttca gaatctggag ctctgggagc gcggcgtgga cgtggagctg      540

ttccgaaatg ctccgtacag cgatgagatg cgccgccgcc tggcgcccga agcgaagccg      600

ggcgatcgcg tcctgctgta cgtggggcgc ttggcgtcgg aaaagaatat cgagcgcatg      660

cgcccggtcc tggacgccat cccggatctg cacctcgcca tcgtcggcga cggcccgcac      720

cgccctgaac tcgagcgcgt gttcgccggg acgcggaccc acttcaccgg atacctccat      780

ggggaggagt tggcgcaggc gtatcgcgcc gcggacgcct tcttgtttcc gtcgaccact      840

gagacgctcg ggctggtctt gtttgaggcg atggcggccg gccttcccat cgtggcggcg      900

gacagcccgc ccacgcgcga ggtcctcgag gacggccggg cgggattcat cttcgatccc      960

gattcgaccg agtccctcat cgcgaccgtc gatctcgtga tgcgggacga agcgaggcga     1020

gaggcggtca gacagcgcgg cttggccatc gcggagcagc tggattggga ggggccgagc     1080

aagcaactgc tcggtcacta cgagcgagtc ttgcagtcgt tcagcgtcgt cgcgggcgcc     1140

gtcaccggca cccgctga                                                   1158


<210>   18
<211>   393
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   18
Met Cys Gly Gly Asp Thr Glu Phe Glu Thr Phe Gly Gly Arg Arg Cys 
                5                   10                  15      

Glu His Met His Gly Pro Val Leu Phe Tyr Asp Gly Leu Ile Cys Leu 
            20                  25                  30          

Ile Ala Leu Leu Asn Arg Leu Leu Trp Pro Arg Leu Asn Arg Asp Arg 
        35                  40                  45              

Glu Asn Val Gly Pro Lys Ala Glu Thr Phe Thr Ser Gly Arg Trp Lys 
    50                  55                  60                  

Asn Leu Ala Pro Val Ala Leu Leu Ile Pro Ala Arg Asn Glu Ala His 
65                  70                  75                  80  

Gln Ile Arg Arg Cys Leu Glu Ala Ile Gly Thr Ser Thr Asp Ser Ser 
                85                  90                  95      

Leu Glu Ile Ile Ala Leu Asp Asp Glu Ser Thr Asp Asp Thr Trp Ser 
            100                 105                 110         

Val Leu Lys Glu Thr Lys Ala Glu Ala Asn Gln Asn Leu Thr Leu Leu 
        115                 120                 125             

Arg Gly Thr Pro Arg Pro Gln Gly Trp Arg Gly Lys Asn Trp Ala Cys 
    130                 135                 140                 

Ala Gln Leu Ala Asp His Ala Gly Asp Ala Glu Ile Leu Ile Phe Ile 
145                 150                 155                 160 

Asp Ala Asp Thr Arg Leu Glu Ala Gly Ala Val Glu Asn Ile Arg Ser 
                165                 170                 175     

Thr Met Leu Ala Arg Asp Ile Gln Leu Leu Ser Val Leu Pro Arg Gln 
            180                 185                 190         

Glu Ala His Gly Leu Ala Ala Leu Leu Val Tyr Leu Leu Pro Trp Ser 
        195                 200                 205             

Leu Met Ala His Val Pro Leu Phe Leu Gly Arg Trp Arg Arg Lys Ala 
    210                 215                 220                 

Leu Pro Ile Ala Ile Gly Gln Val Leu Ala Phe Gln Arg Ser Ala Tyr 
225                 230                 235                 240 

Gln Thr Leu Gly Gly His Ala Ala Val Arg Ser Ala Ile Ala Glu Asp 
                245                 250                 255     

Leu Ala Leu Ala Arg Lys Ala Ala Arg Met Gly Met Ile Gly Ala Phe 
            260                 265                 270         

Leu Asp Gly Ala Asp Ile Ala Ser Cys Thr Met Tyr Thr Ser Trp Val 
        275                 280                 285             

Arg Ala Trp Arg Gly Phe Gln Lys Asn Trp Cys Tyr Thr Val Gly His 
    290                 295                 300                 

Pro Leu Leu Ser Cys Leu Ile Trp Ala Trp Leu Thr Tyr Ala Phe Thr 
305                 310                 315                 320 

Trp Leu Pro Met Tyr Gly Leu Ala Glu Ala Cys Leu Gly His Leu Asp 
                325                 330                 335     

Leu Ala Ala Leu Ser Gln Trp Pro Ala Leu Leu Trp Ile Gly Val Cys 
            340                 345                 350         

Ser Lys Arg Tyr Leu Gln Met Pro Ile Trp Val Phe Val Thr Ala Pro 
        355                 360                 365             

Ile Ser Val Ala Leu Gly Phe Val Leu Ala Cys Asp Ser Trp Ile His 
    370                 375                 380                 

Asn Ala Arg Asn Thr Thr Ile Trp Ser 
385                 390             

<210>   19
<211>   1182
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   19
ttgtgtggtg gggataccga gttcgaaacg ttcggcggaa ggaggtgtga acacatgcat       60

ggaccggtgc tattctacga tggcctgatt tgcctcattg cgctgttgaa ccgcctcctg      120

tggccccgtt tgaaccggga cagggaaaac gtcgggccca aggcggaaac cttcacgagt      180

ggacggtgga agaatcttgc gcccgtcgcc ctcctgattc cggcgcggaa cgaagcgcac      240

cagattcggc ggtgcctcga ggccattggt acgagtaccg attcatccct tgaaattatc      300

gcgctggacg atgagtccac ggacgacacg tggagcgtgt tgaaagagac gaaggccgaa      360

gcgaatcaga acctgaccct tcttcgcgga accccaaggc cacagggatg gcgagggaaa      420

aactgggcat gcgctcaact ggccgatcac gccggagacg ccgaaatcct cattttcatc      480

gacgcggaca cgcgtctcga agcaggcgcc gtcgagaaca tccgatccac catgcttgcg      540

cgagacatcc aacttctttc cgtcctgcca cgccaagaag cacacggcct ggccgccttg      600

cttgtctatt tgctcccttg gagcttgatg gcccacgttc ccttgtttct gggccgatgg      660

cgtcggaaag ccctcccgat tgccatcggc caggtgctcg ccttccagcg ctcggcctat      720

cagacccttg gcggccacgc ggctgtacgc agcgccatcg ctgaggatct cgcgctcgcg      780

cggaaagcag ccaggatggg aatgataggc gcctttctag atggggccga tatcgcctcc      840

tgcaccatgt acacgtcctg ggtccgggcg tggcgcggct tccagaaaaa ctggtgttac      900

accgtcggcc accccctgct ttcgtgtctc atctgggcgt ggctcacgta tgcgttcaca      960

tggctaccca tgtacggcct tgcggaagcc tgcctgggac atctcgatct cgccgccctc     1020

tcgcaatggc ccgcgctgct ctggatagga gtctgctcca aaagatacct gcagatgccg     1080

atatgggtgt ttgtcacggc gcccatcagt gttgccctcg gctttgtgct cgcatgcgat     1140

tcgtggatac acaatgcgcg caacacgacc atttggtcgt ag                        1182


<210>   20
<211>   294
<212>   PRT
<213>   Pelodictyon phaeoclathratiforme BU-1

<400>   20
Val Ser Val Leu Val Pro Ala Arg Asn Glu Ala Leu Asn Ile Glu Arg 
                5                   10                  15      

Cys Val Arg Ser Leu Met Arg Gln Glu Tyr Ala Pro Phe Glu Ile Leu 
            20                  25                  30          

Val Leu Asp Asp Asp Ser Thr Asp Ala Thr Pro Glu Leu Leu Arg Arg 
        35                  40                  45              

Leu Val Val Glu Ser Gly Gly Lys Val Arg Ile Val Gln Gly Glu Ala 
    50                  55                  60                  

Leu Pro Asp Gly Trp His Gly Lys Ser Trp Ala Cys Ser Gln Leu Gly 
65                  70                  75                  80  

His Gln Ala Lys Gly Glu Leu Leu Leu Phe Thr Asp Ala Asp Thr Thr 
                85                  90                  95      

His Lys Pro Asp Ala Leu Arg Arg Thr Val Gly Ala Met Gln Ala Ser 
            100                 105                 110         

Gly Ala Asp Met Leu Ser Leu Met Pro His Gln Glu Leu Gly Ser Phe 
        115                 120                 125             

Trp Glu Lys Leu Val Val Pro Leu Val His Val Ile Leu Met Cys Tyr 
    130                 135                 140                 

Leu Pro Leu Arg Phe Val Arg Thr Ser Arg Arg Ala Ala Phe Cys Phe 
145                 150                 155                 160 

Ala Asn Gly Gln Phe Ile Leu Phe Arg Arg Glu Cys Tyr Thr Arg Ile 
                165                 170                 175     

Asn Gly His Ala Ala Val Arg Glu Ala Ile Val Glu Asp Val Trp Leu 
            180                 185                 190         

Cys Lys Ser Val Lys Lys Ala Gly Gly Thr Val Val Ala Phe Asn Gly 
        195                 200                 205             

Ser Asp Ile Val Ser Cys Arg Met Tyr His Asn Phe Arg Glu Ile Trp 
    210                 215                 220                 

Glu Gly Phe Ser Lys Asn Leu Phe Ala Ala Leu Gly Tyr Ser Thr Pro 
225                 230                 235                 240 

Gly Leu Phe Val Leu Ile Leu Met Ile Ser Ala Leu Tyr Leu Val Pro 
                245                 250                 255     

Cys Leu Phe Phe Ser Tyr Ala Leu Ile Ala Gly Glu Phe Thr Val Ser 
            260                 265                 270         

Leu Phe Trp Leu Pro Leu Met Gln Met Met Val Ala Leu Leu Cys Arg 
        275                 280                 285             

Ile Phe Ile Ala Arg Ile 
    290                 

<210>   21
<211>   317
<212>   PRT
<213>   Chlorobium ferrooxidans DSM 13031

<400>   21
Val Ser Val Leu Val Pro Ala Arg Asn Glu Ala Leu Asn Ile Glu Arg 
                5                   10                  15      

Cys Val Arg Ser Leu Leu Met Gln Asp Tyr Ala Ala Phe Glu Ile Leu 
            20                  25                  30          

Val Leu Asp Asp Gly Ser Thr Asp Ala Thr Pro Gln Leu Leu Gln Thr 
        35                  40                  45              

Leu Leu Asp Glu Ser Gly Gly Arg Leu Arg Val Leu Gln Gly Glu Pro 
    50                  55                  60                  

Leu Pro Asp Gly Trp His Gly Lys Ala Trp Ala Cys Leu Gln Leu Ser 
65                  70                  75                  80  

Arg Gln Ala Lys Gly Asp Leu Leu Leu Phe Thr Asp Ala Asp Thr Lys 
                85                  90                  95      

His Glu Pro Asp Ala Leu Arg Arg Ser Val Ala Ala Leu Asn Ser Glu 
            100                 105                 110         

Lys Gly Asp Met Leu Ser Leu Thr Pro Arg Gln Glu Leu Gly Ser Leu 
        115                 120                 125             

Trp Glu Glu Leu Val Val Pro Leu Val Tyr Val Ile Leu Leu Cys Tyr 
    130                 135                 140                 

Leu Pro Leu Arg Leu Val Arg Thr Ser Arg Asn Pro Ala Phe Cys Phe 
145                 150                 155                 160 

Ala Asn Gly Gln Phe Ile Leu Phe Arg Arg Glu Phe Tyr Asp Arg Ile 
                165                 170                 175     

Asn Gly His Thr Ala Val Arg Gln Ala Leu Ala Glu Asp Ile Gly Leu 
            180                 185                 190         

Cys Arg Glu Val Lys Arg Ala Gly Gly Arg Val Val Ala Phe Asn Gly 
        195                 200                 205             

Phe Asp Ala Val Ser Cys Arg Met Tyr Arg Ser Phe Arg Asp Ile Trp 
    210                 215                 220                 

Glu Gly Phe Ser Lys Asn Leu Tyr Ala Ser Leu Gly Tyr Ser Thr Pro 
225                 230                 235                 240 

Gly Leu Phe Leu Leu Met Thr Leu Thr Ala Ala Phe Tyr Ile Ala Pro 
                245                 250                 255     

Tyr Leu Phe Phe Phe Tyr Ala Leu Ile Ala Gly Lys Phe Thr Met Leu 
            260                 265                 270         

Leu Phe Trp Leu Pro Leu Thr Gln Met Val Ile Ala Leu Leu Ser Arg 
        275                 280                 285             

Val Ile Ile Ala Arg Leu Phe Gly Gln Ser Thr Ala Met Val Phe Leu 
    290                 295                 300                 

Asn Leu Phe Ser Gln Leu Ile Leu Ile Ala Ile Ala Trp 
305                 310                 315         

<210>   22
<211>   320
<212>   PRT
<213>   Chlorobium chlorochromatii CaD3

<400>   22
Val Ser Ile Leu Val Pro Ala Arg Asn Glu Ala His Asn Ile Glu Arg 
                5                   10                  15      

Cys Ile Asn Ser Leu Leu Gln Gln Arg Tyr Glu Ser Phe Glu Val Leu 
            20                  25                  30          

Val Leu Asp Asp Gly Ser Thr Asp Ala Thr Pro Thr Leu Leu Ala Glu 
        35                  40                  45              

Leu Ala Gln His Ala Gly Gly Val Leu Gln Val Leu Gln Gly Asp Pro 
    50                  55                  60                  

Leu Pro Gln Gly Trp His Gly Lys Ala Trp Ala Cys Gln Gln Leu Gly 
65                  70                  75                  80  

Glu Ala Ala His Gly Asp Leu Leu Leu Phe Thr Asp Ala Asp Thr Val 
                85                  90                  95      

His His Pro Thr Ala Leu Ala Arg Ser Val Ala Ala Leu Gln Ala Ser 
            100                 105                 110         

Gln Ala Ser Met Leu Ser Met Thr Pro Leu Gln Thr Met His Ser Trp 
        115                 120                 125             

Trp Glu Lys Ile Val Val Pro Leu Val Tyr Val Val Leu Met Asn Phe 
    130                 135                 140                 

Leu Pro Leu Arg Phe Val Arg Thr Thr Ser Ile Pro Ala Phe Ser Phe 
145                 150                 155                 160 

Ala Asn Gly Gln Phe Ile Leu Ile Glu Arg Thr Met Tyr Arg Gln Leu 
                165                 170                 175     

Asn Gly His Ala Ala Val Arg Gln Gln Leu Val Glu Asp Val Trp Leu 
            180                 185                 190         

Cys Met Ala Val Lys Lys Ala Gly Gly Arg Val Val Ala Ile Asn Gly 
        195                 200                 205             

Val Asp Leu Val Ser Cys Arg Met Tyr Arg Ser Gly Lys Glu Val Trp 
    210                 215                 220                 

Glu Gly Phe Ser Lys Asn Ile Phe Ala Gly Leu Gly Tyr Tyr His Ser 
225                 230                 235                 240 

Ala Leu Phe Gly Leu Leu Ala Leu Ile Ala Leu Phe Tyr Ile Ile Pro 
                245                 250                 255     

Ile Ala Leu Leu Thr Thr Ser Val Val Gln Ala Asn Tyr Ser Ala Thr 
            260                 265                 270         

His Phe Trp Leu Pro Leu Val Gln Val Val Leu Ala Phe Ala Asn Arg 
        275                 280                 285             

Trp Leu Val Ala Phe Thr Phe His Gln Ser Arg Phe Met Val Phe Phe 
    290                 295                 300                 

His Pro Leu Thr Met Val Ala Phe Phe Ala Ile Ala Cys Asn Ser Trp 
305                 310                 315                 320 

<210>   23
<211>   271
<212>   PRT
<213>   Chlorobium limicola DSM 245

<400>   23
Val Ser Val Leu Val Pro Val Arg Asn Glu Glu His Val Ile Glu Ala 
                5                   10                  15      

Cys Val Leu Ser Leu Leu Ala Gln Asp Tyr Pro Arg Tyr Glu Val Val 
            20                  25                  30          

Val Leu Asp Asp Cys Ser Glu Asp Arg Ser Leu Glu Ile Leu Arg Arg 
        35                  40                  45              

Leu Glu Ala Ala Ser Gly Ser Arg Leu Arg Ile Val Gln Gly Lys Pro 
    50                  55                  60                  

Leu Pro Glu Gly Trp His Gly Lys Ala Trp Ala Cys Arg Gln Leu Gly 
65                  70                  75                  80  

Asp Leu Gly Gly Gly Glu Leu Leu Leu Phe Thr Asp Ala Asp Thr Arg 
                85                  90                  95      

His Lys Pro Glu Gly Ile Ser Arg Ser Val Ala Ala Leu Tyr Glu Ser 
            100                 105                 110         

Gly Ala Asp Met Leu Thr Leu Thr Pro Tyr Gln Glu Met Ala Gly Phe 
        115                 120                 125             

Leu Glu Lys Leu Val Ile Pro Leu Val Tyr Phe Ile Leu Met Cys Tyr 
    130                 135                 140                 

Leu Pro Leu Arg Phe Val Arg Thr Ser Pro Lys Ser Val Phe Cys Ser 
145                 150                 155                 160 

Ala Ile Gly Gln Phe Met Leu Phe Arg Arg Glu Ile Tyr Arg Asn Ile 
                165                 170                 175     

Gly Gly His Arg Ala Val Lys Ala Ala Ile Val Glu Asp Val Trp Leu 
            180                 185                 190         

Cys Arg Glu Val Lys Lys Ala Gly Gly Arg Val Ala Val Tyr Asn Gly 
        195                 200                 205             

Ile Asp Ala Leu Ser Cys Arg Met Tyr Arg Ser Pro Gly Glu Ile Ile 
    210                 215                 220                 

Arg Gly Phe Ser Lys Asn Leu Phe Ala Gly Leu Gly Tyr Arg Ser Phe 
225                 230                 235                 240 

Gly Leu Phe Ser Leu Val Val Leu Thr Leu Ala Phe His Val Leu Pro 
                245                 250                 255     

Tyr Gly Phe Leu Thr Ala Ala Leu Leu Ser Gly Asp Phe Ser Ala 
            260                 265                 270     

<210>   24
<211>   319
<212>   PRT
<213>   Pelodictyon luteolum DSM 273

<400>   24
Val Ser Val Leu Val Pro Ala Arg Asn Glu Glu Arg Ser Ile Ala Arg 
                5                   10                  15      

Cys Val Gln Ser Leu Leu Met Gln Asp Tyr Pro Asp Phe Glu Val Ile 
            20                  25                  30          

Val Leu Asp Asp Ala Ser Thr Asp Ala Thr Leu Ser Ile Leu Gln Ala 
        35                  40                  45              

Leu Glu Ala Glu Ser Cys Gly Arg Leu Arg Val Leu Arg Gly Ala Val 
    50                  55                  60                  

Leu Pro Glu Gly Trp His Gly Lys Ser Trp Ala Cys Arg Gln Leu Ala 
65                  70                  75                  80  

Glu Lys Ala Ser Gly Glu Met Leu Leu Phe Thr Asp Ala Asp Thr Phe 
                85                  90                  95      

His Arg Pro Gln Ala Leu Arg Arg Ala Val Thr Ala Leu Gln Glu Gly 
            100                 105                 110         

Arg Gly Asp Met Leu Ser Ile Thr Pro Arg Gln Glu Leu Gly Ser Phe 
        115                 120                 125             

Phe Glu His Leu Val Val Pro Leu Val Tyr Val Ile Leu Met Ser Tyr 
    130                 135                 140                 

Leu Pro Leu Arg Leu Val Arg Thr Leu Arg Asn Pro Ala Phe Cys Phe 
145                 150                 155                 160 

Ala Asn Gly Gln Phe Ile Leu Phe Arg Arg Glu Phe Tyr Trp Lys Val 
                165                 170                 175     

Asn Gly His Glu Ala Val Arg Asp Ala Leu Val Glu Asp Val Trp Leu 
            180                 185                 190         

Cys Met Ala Val Lys Lys Ala Gly Gly Arg Val Leu Ser Phe Asn Gly 
        195                 200                 205             

Thr Asp Ala Leu Ser Cys Arg Met Tyr Arg Asn Phe Arg Glu Val Trp 
    210                 215                 220                 

Glu Gly Phe Ser Lys Asn Val Phe Ala Gly Leu Gly Ser Ser Ile Pro 
225                 230                 235                 240 

Gly Leu Ala Ala Phe Val Leu Phe Thr Ala Ala Phe His Leu Ala Pro 
                245                 250                 255     

Trp Gly Phe Leu Leu Tyr Ala Leu Phe Val Gly Ala Ser Gly Pro Ala 
            260                 265                 270         

Leu Val Leu Leu Pro Leu Leu Gln Leu Ala Val Ala Leu Ser Gly Arg 
        275                 280                 285             

Val Leu Val Ala Arg Arg Phe Asp Gln Pro Thr Ala Leu Thr Leu Leu 
    290                 295                 300                 

Asp Pro Leu Ala Arg Gly Leu Leu Leu Ala Ile Ala Leu Asn Ser 
305                 310                 315                 

<210>   25
<211>   393
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 18

<400>   25
Met Cys Gly Gly Asp Thr Glu Phe Glu Thr Phe Gly Gly Arg Arg Cys 
                5                   10                  15      

Glu His Met His Gly Pro Val Leu Phe Tyr Asp Gly Leu Ile Cys Leu 
            20                  25                  30          

Ile Ala Leu Leu Asn Arg Leu Leu Trp Pro Arg Leu Asn Arg Asp Arg 
        35                  40                  45              

Glu Asn Val Gly Pro Arg Ala Glu Thr Phe Thr Ser Gly Arg Trp Lys 
    50                  55                  60                  

Asn Leu Ala Pro Val Ala Leu Leu Ile Pro Ala Arg Asn Glu Ala His 
65                  70                  75                  80  

Gln Ile Arg Arg Cys Leu Glu Ala Ile Gly Thr Ser Thr Asp Ser Ser 
                85                  90                  95      

Leu Glu Ile Ile Ala Leu Asp Asp Glu Ser Thr Asp Asp Thr Trp Ser 
            100                 105                 110         

Val Leu Lys Glu Thr Lys Ala Glu Ala Asn Gln Asn Leu Thr Leu Leu 
        115                 120                 125             

Arg Gly Thr Pro Arg Pro Gln Gly Trp Arg Gly Lys Asn Trp Ala Cys 
    130                 135                 140                 

Ala Gln Leu Ala Asp His Ala Gly Asp Ala Glu Ile Leu Ile Phe Ile 
145                 150                 155                 160 

Asp Ala Asp Thr Arg Leu Glu Ala Gly Ala Val Glu Asn Ile Arg Ser 
                165                 170                 175     

Thr Met Leu Ala Arg Asp Ile Gln Leu Leu Ser Val Leu Pro Arg Gln 
            180                 185                 190         

Glu Ala His Gly Leu Ala Ala Leu Leu Val Tyr Leu Leu Pro Trp Ser 
        195                 200                 205             

Leu Met Ala His Val Pro Leu Phe Leu Gly Arg Trp Arg Arg Lys Ala 
    210                 215                 220                 

Leu Pro Ile Ala Ile Gly Gln Val Leu Ala Phe Gln Arg Ser Ala Tyr 
225                 230                 235                 240 

Gln Thr Leu Gly Gly His Ala Ala Val Arg Ser Ala Ile Ala Glu Asp 
                245                 250                 255     

Leu Ala Leu Ala Arg Lys Ala Ala Arg Met Gly Met Ile Gly Ala Phe 
            260                 265                 270         

Leu Asp Gly Ala Asp Ile Ala Ser Cys Thr Met Tyr Thr Ser Trp Val 
        275                 280                 285             

Arg Ala Trp Arg Gly Phe Gln Lys Asn Trp Cys Tyr Thr Val Gly His 
    290                 295                 300                 

Pro Leu Leu Ser Cys Leu Ile Trp Ala Trp Leu Thr Tyr Ala Phe Thr 
305                 310                 315                 320 

Trp Leu Pro Met Tyr Gly Leu Ala Glu Ala Cys Leu Gly His Leu Asp 
                325                 330                 335     

Leu Ala Ala Leu Ser Gln Trp Pro Ala Leu Leu Trp Ile Gly Val Cys 
            340                 345                 350         

Ser Lys Arg Tyr Leu Gln Met Pro Ile Trp Val Phe Val Thr Ala Pro 
        355                 360                 365             

Ile Ser Val Ala Leu Gly Phe Val Leu Ala Cys Asp Ser Trp Ile His 
    370                 375                 380                 

Asn Ala Arg Asn Thr Thr Ile Trp Ser 
385                 390             

<210>   26
<211>   393
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 18

<400>   26
Met Cys Gly Gly Asp Thr Glu Phe Glu Thr Phe Gly Gly Arg Arg Cys 
                5                   10                  15      

Glu His Met His Gly Pro Val Leu Phe Tyr Asp Gly Leu Ile Cys Leu 
            20                  25                  30          

Ile Ala Leu Leu Asn Arg Leu Leu Trp Pro Arg Leu Asn Arg Asp Arg 
        35                  40                  45              

Glu Asn Val Gly Pro Lys Ala Glu Thr Phe Thr Ser Gly Arg Trp Lys 
    50                  55                  60                  

Asn Leu Ala Pro Val Ala Leu Leu Ile Pro Ala Arg Asn Glu Ala His 
65                  70                  75                  80  

Asn Ile Arg Arg Cys Leu Glu Ala Ile Gly Thr Ser Thr Asp Ser Ser 
                85                  90                  95      

Leu Glu Ile Ile Ala Leu Asp Asp Glu Ser Thr Asp Asp Thr Trp Ser 
            100                 105                 110         

Val Leu Lys Glu Thr Lys Ala Glu Ala Asn Gln Asn Leu Thr Leu Leu 
        115                 120                 125             

Arg Gly Thr Pro Arg Pro Gln Gly Trp Arg Gly Lys Asn Trp Ala Cys 
    130                 135                 140                 

Ala Gln Leu Ala Asp His Ala Gly Asp Ala Glu Ile Leu Ile Phe Ile 
145                 150                 155                 160 

Asp Ala Asp Thr Arg Leu Glu Ala Gly Ala Val Glu Asn Ile Arg Ser 
                165                 170                 175     

Thr Met Leu Ala Arg Asp Ile Gln Leu Leu Ser Val Leu Pro Arg Gln 
            180                 185                 190         

Glu Ala His Gly Leu Ala Ala Leu Leu Val Tyr Leu Leu Pro Trp Ser 
        195                 200                 205             

Leu Met Ala His Val Pro Leu Phe Leu Gly Arg Trp Arg Arg Lys Ala 
    210                 215                 220                 

Leu Pro Ile Ala Ile Gly Gln Val Leu Ala Phe Gln Arg Ser Ala Tyr 
225                 230                 235                 240 

Gln Thr Leu Gly Gly His Ala Ala Val Arg Ser Ala Ile Ala Glu Asp 
                245                 250                 255     

Leu Ala Leu Ala Arg Lys Ala Ala Arg Met Gly Met Ile Gly Ala Phe 
            260                 265                 270         

Leu Asp Gly Ala Asp Ile Ala Ser Cys Thr Met Tyr Thr Ser Trp Val 
        275                 280                 285             

Arg Ala Trp Arg Gly Phe Gln Lys Asn Trp Cys Tyr Thr Val Gly His 
    290                 295                 300                 

Pro Leu Leu Ser Cys Leu Ile Trp Ala Trp Leu Thr Tyr Ala Phe Thr 
305                 310                 315                 320 

Trp Leu Pro Met Tyr Gly Leu Ala Glu Ala Cys Leu Gly His Leu Asp 
                325                 330                 335     

Leu Ala Ala Leu Ser Gln Trp Pro Ala Leu Leu Trp Ile Gly Val Cys 
            340                 345                 350         

Ser Lys Arg Tyr Leu Gln Met Pro Ile Trp Val Phe Val Thr Ala Pro 
        355                 360                 365             

Ile Ser Val Ala Leu Gly Phe Val Leu Ala Cys Asp Ser Trp Ile His 
    370                 375                 380                 

Asn Ala Arg Asn Thr Thr Ile Trp Ser 
385                 390             

<210>   27
<211>   393
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 18

<400>   27
Met Cys Gly Gly Asp Thr Glu Phe Glu Thr Phe Gly Gly Arg Arg Cys 
                5                   10                  15      

Glu His Met His Gly Pro Val Leu Phe Tyr Asp Gly Leu Ile Cys Leu 
            20                  25                  30          

Ile Ala Leu Leu Asn Arg Leu Leu Trp Pro Arg Ile Asn Arg Asp Arg 
        35                  40                  45              

Glu Asn Val Gly Pro Lys Ala Glu Thr Phe Thr Ser Gly Arg Trp Lys 
    50                  55                  60                  

Asn Leu Ala Pro Val Ala Leu Leu Ile Pro Ala Arg Asn Glu Ala His 
65                  70                  75                  80  

Gln Ile Arg Arg Cys Leu Glu Ala Ile Gly Thr Ser Thr Asp Ser Ser 
                85                  90                  95      

Leu Glu Ile Ile Ala Leu Asp Asp Glu Ser Thr Asp Asp Thr Trp Ser 
            100                 105                 110         

Val Leu Lys Glu Thr Lys Ala Glu Ala Asn Gln Asn Leu Thr Leu Leu 
        115                 120                 125             

Arg Gly Thr Pro Arg Pro Gln Gly Trp Arg Gly Lys Asn Trp Ala Cys 
    130                 135                 140                 

Ala Gln Leu Ala Asp His Ala Gly Asp Ala Glu Ile Leu Ile Phe Ile 
145                 150                 155                 160 

Asp Ala Asp Thr Arg Leu Glu Ala Gly Ala Val Glu Asn Ile Arg Ser 
                165                 170                 175     

Thr Met Leu Ala Arg Asp Ile Gln Leu Leu Ser Val Leu Pro Arg Gln 
            180                 185                 190         

Glu Ala His Gly Leu Ala Ala Leu Leu Val Tyr Leu Leu Pro Trp Ser 
        195                 200                 205             

Leu Met Ala His Val Pro Leu Phe Leu Gly Arg Trp Arg Arg Lys Ala 
    210                 215                 220                 

Leu Pro Ile Ala Ile Gly Gln Val Leu Ala Phe Gln Arg Ser Ala Tyr 
225                 230                 235                 240 

Gln Thr Leu Gly Gly His Ala Ala Val Arg Ser Ala Ile Ala Glu Asp 
                245                 250                 255     

Leu Ala Leu Ala Arg Lys Ala Ala Arg Met Gly Met Ile Gly Ala Phe 
            260                 265                 270         

Leu Asp Gly Ala Asp Ile Ala Ser Cys Thr Met Tyr Thr Ser Trp Val 
        275                 280                 285             

Arg Ala Trp Arg Gly Phe Gln Lys Asn Trp Cys Tyr Thr Val Gly His 
    290                 295                 300                 

Pro Leu Leu Ser Cys Leu Ile Trp Ala Trp Leu Thr Tyr Ala Phe Thr 
305                 310                 315                 320 

Trp Leu Pro Met Tyr Gly Leu Ala Glu Ala Cys Leu Gly His Leu Asp 
                325                 330                 335     

Leu Ala Ala Leu Ser Gln Trp Pro Ala Leu Leu Trp Ile Gly Val Cys 
            340                 345                 350         

Ser Lys Arg Tyr Leu Gln Met Pro Ile Trp Val Phe Val Thr Ala Pro 
        355                 360                 365             

Ile Ser Val Ala Leu Gly Phe Val Leu Ala Cys Asp Ser Trp Ile His 
    370                 375                 380                 

Asn Ala Arg Asn Thr Thr Ile Trp Ser 
385                 390             

<210>   28
<211>   393
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 18

<400>   28
Met Cys Gly Gly Asp Thr Glu Phe Glu Thr Phe Gly Gly Arg Arg Cys 
                5                   10                  15      

Glu His Met His Gly Pro Val Leu Phe Tyr Asp Gly Leu Ile Cys Leu 
            20                  25                  30          

Ile Ala Leu Leu Asn Arg Leu Leu Trp Pro Arg Leu Asn Arg Asp Arg 
        35                  40                  45              

Glu Asn Val Gly Pro Lys Ala Glu Thr Phe Thr Ser Gly Arg Trp Lys 
    50                  55                  60                  

Asn Leu Ala Pro Val Ala Leu Leu Ile Pro Ala Arg Asn Glu Ala His 
65                  70                  75                  80  

Gln Ile Arg Arg Cys Leu Glu Ala Ile Gly Thr Ser Thr Asp Ser Ser 
                85                  90                  95      

Leu Glu Ile Ile Ala Leu Asp Asp Glu Ser Thr Asp Asp Thr Trp Ser 
            100                 105                 110         

Val Leu Lys Glu Thr Lys Ala Glu Ala Asn Gln Asn Leu Thr Leu Leu 
        115                 120                 125             

Arg Gly Thr Pro Arg Pro Gln Gly Trp Arg Gly Lys Asn Trp Ala Cys 
    130                 135                 140                 

Ala Gln Leu Ala Asp His Ala Gly Asp Ala Glu Ile Leu Ile Phe Ile 
145                 150                 155                 160 

Asp Ala Asp Thr Arg Leu Glu Ala Gly Ala Val Asp Asn Ile Arg Ser 
                165                 170                 175     

Thr Met Leu Ala Arg Asp Ile Gln Leu Leu Ser Val Leu Pro Arg Gln 
            180                 185                 190         

Glu Ala His Gly Leu Ala Ala Leu Leu Val Tyr Leu Leu Pro Trp Ser 
        195                 200                 205             

Leu Met Ala His Val Pro Leu Phe Leu Gly Arg Trp Arg Arg Lys Ala 
    210                 215                 220                 

Leu Pro Ile Ala Ile Gly Gln Val Leu Ala Phe Gln Arg Ser Ala Tyr 
225                 230                 235                 240 

Gln Thr Leu Gly Gly His Ala Ala Val Arg Ser Ala Ile Ala Glu Asp 
                245                 250                 255     

Leu Ala Leu Ala Arg Lys Ala Ala Arg Met Gly Met Ile Gly Ala Phe 
            260                 265                 270         

Leu Asp Gly Ala Asp Ile Ala Ser Cys Thr Met Tyr Thr Ser Trp Val 
        275                 280                 285             

Arg Ala Trp Arg Gly Phe Gln Lys Asn Trp Cys Tyr Thr Val Gly His 
    290                 295                 300                 

Pro Leu Leu Ser Cys Leu Ile Trp Ala Trp Leu Thr Tyr Ala Phe Thr 
305                 310                 315                 320 

Trp Leu Pro Met Tyr Gly Leu Ala Glu Ala Cys Leu Gly His Leu Asp 
                325                 330                 335     

Leu Ala Ala Leu Ser Gln Trp Pro Ala Leu Leu Trp Ile Gly Val Cys 
            340                 345                 350         

Ser Lys Arg Tyr Leu Gln Met Pro Ile Trp Val Phe Val Thr Ala Pro 
        355                 360                 365             

Ile Ser Val Ala Leu Gly Phe Val Leu Ala Cys Asp Ser Trp Ile His 
    370                 375                 380                 

Asn Ala Arg Asn Thr Thr Ile Trp Ser 
385                 390             

<210>   29
<211>   393
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 18

<400>   29
Met Cys Gly Gly Asp Thr Glu Phe Glu Thr Phe Gly Gly Arg Arg Cys 
                5                   10                  15      

Glu His Met His Gly Pro Val Leu Phe Tyr Asp Gly Leu Ile Cys Leu 
            20                  25                  30          

Ile Ala Leu Leu Asn Arg Leu Leu Trp Pro Arg Leu Asn Arg Asp Arg 
        35                  40                  45              

Glu Asn Val Gly Pro Lys Ala Glu Thr Phe Thr Ser Gly Arg Trp Lys 
    50                  55                  60                  

Asn Leu Ala Pro Val Ala Leu Leu Ile Pro Ala Arg Asn Glu Ala His 
65                  70                  75                  80  

Gln Ile Arg Arg Cys Leu Glu Ala Ile Gly Thr Ser Thr Asp Ser Ser 
                85                  90                  95      

Leu Glu Ile Ile Ala Leu Asp Asp Glu Ser Thr Asp Asp Thr Trp Ser 
            100                 105                 110         

Val Leu Lys Glu Thr Lys Ala Glu Ala Asn Gln Asn Leu Thr Leu Leu 
        115                 120                 125             

Arg Gly Thr Pro Arg Pro Gln Gly Trp Arg Gly Lys Asn Trp Ala Cys 
    130                 135                 140                 

Ala Gln Leu Ala Asp His Ala Gly Asp Ala Glu Ile Leu Ile Phe Ile 
145                 150                 155                 160 

Asp Ala Asp Thr Arg Leu Glu Ala Gly Ala Val Glu Asn Ile Arg Ser 
                165                 170                 175     

Thr Met Leu Ala Arg Asp Ile Gln Leu Leu Ser Val Leu Pro Arg Gln 
            180                 185                 190         

Asp Ala His Gly Leu Ala Ala Leu Leu Val Tyr Leu Leu Pro Trp Ser 
        195                 200                 205             

Leu Met Ala His Val Pro Leu Phe Leu Gly Arg Trp Arg Arg Lys Ala 
    210                 215                 220                 

Leu Pro Ile Ala Ile Gly Gln Val Leu Ala Phe Gln Arg Ser Ala Tyr 
225                 230                 235                 240 

Gln Thr Leu Gly Gly His Ala Ala Val Arg Ser Ala Ile Ala Glu Asp 
                245                 250                 255     

Leu Ala Leu Ala Arg Lys Ala Ala Arg Met Gly Met Ile Gly Ala Phe 
            260                 265                 270         

Leu Asp Gly Ala Asp Ile Ala Ser Cys Thr Met Tyr Thr Ser Trp Val 
        275                 280                 285             

Arg Ala Trp Arg Gly Phe Gln Lys Asn Trp Cys Tyr Thr Val Gly His 
    290                 295                 300                 

Pro Leu Leu Ser Cys Leu Ile Trp Ala Trp Leu Thr Tyr Ala Phe Thr 
305                 310                 315                 320 

Trp Leu Pro Met Tyr Gly Leu Ala Glu Ala Cys Leu Gly His Leu Asp 
                325                 330                 335     

Leu Ala Ala Leu Ser Gln Trp Pro Ala Leu Leu Trp Ile Gly Val Cys 
            340                 345                 350         

Ser Lys Arg Tyr Leu Gln Met Pro Ile Trp Val Phe Val Thr Ala Pro 
        355                 360                 365             

Ile Ser Val Ala Leu Gly Phe Val Leu Ala Cys Asp Ser Trp Ile His 
    370                 375                 380                 

Asn Ala Arg Asn Thr Thr Ile Trp Ser 
385                 390             

<210>   30
<211>   1182
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 19

<400>   30
ttgtgtggtg gggataccga gttcgaaacg ttcggcggaa ggaggtgtga acacatgcat       60

ggaccggtgc tattctacga tggcctgatt tgcctcattg cgctgttgaa ccgcctcctg      120

tggccccgtt tgaaccggga cagggaaaac gtcgggcccc gtgcggaaac cttcacgagt      180

ggacggtgga agaatcttgc gcccgtcgcc ctcctgattc cggcgcggaa cgaagcgcac      240

cagattcggc ggtgcctcga ggccattggt acgagtaccg attcatccct tgaaattatc      300

gcgctggacg atgagtccac ggacgacacg tggagcgtgt tgaaagagac gaaggccgaa      360

gcgaatcaga acctgaccct tcttcgcgga accccaaggc cacagggatg gcgagggaaa      420

aactgggcat gcgctcaact ggccgatcac gccggagacg ccgaaatcct cattttcatc      480

gacgcggaca cgcgtctcga agcaggcgcc gtcgagaaca tccgatccac catgcttgcg      540

cgagacatcc aacttctttc cgtcctgcca cgccaagaag cacacggcct ggccgccttg      600

cttgtctatt tgctcccttg gagcttgatg gcccacgttc ccttgtttct gggccgatgg      660

cgtcggaaag ccctcccgat tgccatcggc caggtgctcg ccttccagcg ctcggcctat      720

cagacccttg gcggccacgc ggctgtacgc agcgccatcg ctgaggatct cgcgctcgcg      780

cggaaagcag ccaggatggg aatgataggc gcctttctag atggggccga tatcgcctcc      840

tgcaccatgt acacgtcctg ggtccgggcg tggcgcggct tccagaaaaa ctggtgttac      900

accgtcggcc accccctgct ttcgtgtctc atctgggcgt ggctcacgta tgcgttcaca      960

tggctaccca tgtacggcct tgcggaagcc tgcctgggac atctcgatct cgccgccctc     1020

tcgcaatggc ccgcgctgct ctggatagga gtctgctcca aaagatacct gcagatgccg     1080

atatgggtgt ttgtcacggc gcccatcagt gttgccctcg gctttgtgct cgcatgcgat     1140

tcgtggatac acaatgcgcg caacacgacc atttggtcgt ag                        1182


<210>   31
<211>   1182
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 19

<400>   31
ttgtgtggtg gggataccga gttcgaaacg ttcggcggaa ggaggtgtga acacatgcat       60

ggaccggtgc tattctacga tggcctgatt tgcctcattg cgctgttgaa ccgcctcctg      120

tggccccgtt tgaaccggga cagggaaaac gtcgggccca aggcggaaac cttcacgagt      180

ggacggtgga agaatcttgc gcccgtcgcc ctcctgattc cggcgcggaa cgaagcgcac      240

aatattcggc ggtgcctcga ggccattggt acgagtaccg attcatccct tgaaattatc      300

gcgctggacg atgagtccac ggacgacacg tggagcgtgt tgaaagagac gaaggccgaa      360

gcgaatcaga acctgaccct tcttcgcgga accccaaggc cacagggatg gcgagggaaa      420

aactgggcat gcgctcaact ggccgatcac gccggagacg ccgaaatcct cattttcatc      480

gacgcggaca cgcgtctcga agcaggcgcc gtcgagaaca tccgatccac catgcttgcg      540

cgagacatcc aacttctttc cgtcctgcca cgccaagaag cacacggcct ggccgccttg      600

cttgtctatt tgctcccttg gagcttgatg gcccacgttc ccttgtttct gggccgatgg      660

cgtcggaaag ccctcccgat tgccatcggc caggtgctcg ccttccagcg ctcggcctat      720

cagacccttg gcggccacgc ggctgtacgc agcgccatcg ctgaggatct cgcgctcgcg      780

cggaaagcag ccaggatggg aatgataggc gcctttctag atggggccga tatcgcctcc      840

tgcaccatgt acacgtcctg ggtccgggcg tggcgcggct tccagaaaaa ctggtgttac      900

accgtcggcc accccctgct ttcgtgtctc atctgggcgt ggctcacgta tgcgttcaca      960

tggctaccca tgtacggcct tgcggaagcc tgcctgggac atctcgatct cgccgccctc     1020

tcgcaatggc ccgcgctgct ctggatagga gtctgctcca aaagatacct gcagatgccg     1080

atatgggtgt ttgtcacggc gcccatcagt gttgccctcg gctttgtgct cgcatgcgat     1140

tcgtggatac acaatgcgcg caacacgacc atttggtcgt ag                        1182


<210>   32
<211>   1182
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 19

<400>   32
ttgtgtggtg gggataccga gttcgaaacg ttcggcggaa ggaggtgtga acacatgcat       60

ggaccggtgc tattctacga tggcctgatt tgcctcattg cgctgttgaa ccgcctcctg      120

tggccccgta ttaaccggga cagggaaaac gtcgggccca aggcggaaac cttcacgagt      180

ggacggtgga agaatcttgc gcccgtcgcc ctcctgattc cggcgcggaa cgaagcgcac      240

cagattcggc ggtgcctcga ggccattggt acgagtaccg attcatccct tgaaattatc      300

gcgctggacg atgagtccac ggacgacacg tggagcgtgt tgaaagagac gaaggccgaa      360

gcgaatcaga acctgaccct tcttcgcgga accccaaggc cacagggatg gcgagggaaa      420

aactgggcat gcgctcaact ggccgatcac gccggagacg ccgaaatcct cattttcatc      480

gacgcggaca cgcgtctcga agcaggcgcc gtcgagaaca tccgatccac catgcttgcg      540

cgagacatcc aacttctttc cgtcctgcca cgccaagaag cacacggcct ggccgccttg      600

cttgtctatt tgctcccttg gagcttgatg gcccacgttc ccttgtttct gggccgatgg      660

cgtcggaaag ccctcccgat tgccatcggc caggtgctcg ccttccagcg ctcggcctat      720

cagacccttg gcggccacgc ggctgtacgc agcgccatcg ctgaggatct cgcgctcgcg      780

cggaaagcag ccaggatggg aatgataggc gcctttctag atggggccga tatcgcctcc      840

tgcaccatgt acacgtcctg ggtccgggcg tggcgcggct tccagaaaaa ctggtgttac      900

accgtcggcc accccctgct ttcgtgtctc atctgggcgt ggctcacgta tgcgttcaca      960

tggctaccca tgtacggcct tgcggaagcc tgcctgggac atctcgatct cgccgccctc     1020

tcgcaatggc ccgcgctgct ctggatagga gtctgctcca aaagatacct gcagatgccg     1080

atatgggtgt ttgtcacggc gcccatcagt gttgccctcg gctttgtgct cgcatgcgat     1140

tcgtggatac acaatgcgcg caacacgacc atttggtcgt ag                        1182


<210>   33
<211>   1182
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 19

<400>   33
ttgtgtggtg gggataccga gttcgaaacg ttcggcggaa ggaggtgtga acacatgcat       60

ggaccggtgc tattctacga tggcctgatt tgcctcattg cgctgttgaa ccgcctcctg      120

tggccccgtt tgaaccggga cagggaaaac gtcgggccca aggcggaaac cttcacgagt      180

ggacggtgga agaatcttgc gcccgtcgcc ctcctgattc cggcgcggaa cgaagcgcac      240

cagattcggc ggtgcctcga ggccattggt acgagtaccg attcatccct tgaaattatc      300

gcgctggacg atgagtccac ggacgacacg tggagcgtgt tgaaagagac gaaggccgaa      360

gcgaatcaga acctgaccct tcttcgcgga accccaaggc cacagggatg gcgagggaaa      420

aactgggcat gcgctcaact ggccgatcac gccggagacg ccgaaatcct cattttcatc      480

gacgcggaca cgcgtctcga agcaggcgcc gtcgataaca tccgatccac catgcttgcg      540

cgagacatcc aacttctttc cgtcctgcca cgccaagaag cacacggcct ggccgccttg      600

cttgtctatt tgctcccttg gagcttgatg gcccacgttc ccttgtttct gggccgatgg      660

cgtcggaaag ccctcccgat tgccatcggc caggtgctcg ccttccagcg ctcggcctat      720

cagacccttg gcggccacgc ggctgtacgc agcgccatcg ctgaggatct cgcgctcgcg      780

cggaaagcag ccaggatggg aatgataggc gcctttctag atggggccga tatcgcctcc      840

tgcaccatgt acacgtcctg ggtccgggcg tggcgcggct tccagaaaaa ctggtgttac      900

accgtcggcc accccctgct ttcgtgtctc atctgggcgt ggctcacgta tgcgttcaca      960

tggctaccca tgtacggcct tgcggaagcc tgcctgggac atctcgatct cgccgccctc     1020

tcgcaatggc ccgcgctgct ctggatagga gtctgctcca aaagatacct gcagatgccg     1080

atatgggtgt ttgtcacggc gcccatcagt gttgccctcg gctttgtgct cgcatgcgat     1140

tcgtggatac acaatgcgcg caacacgacc atttggtcgt ag                        1182


<210>   34
<211>   1182
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 19

<400>   34
ttgtgtggtg gggataccga gttcgaaacg ttcggcggaa ggaggtgtga acacatgcat       60

ggaccggtgc tattctacga tggcctgatt tgcctcattg cgctgttgaa ccgcctcctg      120

tggccccgtt tgaaccggga cagggaaaac gtcgggccca aggcggaaac cttcacgagt      180

ggacggtgga agaatcttgc gcccgtcgcc ctcctgattc cggcgcggaa cgaagcgcac      240

cagattcggc ggtgcctcga ggccattggt acgagtaccg attcatccct tgaaattatc      300

gcgctggacg atgagtccac ggacgacacg tggagcgtgt tgaaagagac gaaggccgaa      360

gcgaatcaga acctgaccct tcttcgcgga accccaaggc cacagggatg gcgagggaaa      420

aactgggcat gcgctcaact ggccgatcac gccggagacg ccgaaatcct cattttcatc      480

gacgcggaca cgcgtctcga agcaggcgcc gtcgagaaca tccgatccac catgcttgcg      540

cgagacatcc aacttctttc cgtcctgcca cgccaagatg cacacggcct ggccgccttg      600

cttgtctatt tgctcccttg gagcttgatg gcccacgttc ccttgtttct gggccgatgg      660

cgtcggaaag ccctcccgat tgccatcggc caggtgctcg ccttccagcg ctcggcctat      720

cagacccttg gcggccacgc ggctgtacgc agcgccatcg ctgaggatct cgcgctcgcg      780

cggaaagcag ccaggatggg aatgataggc gcctttctag atggggccga tatcgcctcc      840

tgcaccatgt acacgtcctg ggtccgggcg tggcgcggct tccagaaaaa ctggtgttac      900

accgtcggcc accccctgct ttcgtgtctc atctgggcgt ggctcacgta tgcgttcaca      960

tggctaccca tgtacggcct tgcggaagcc tgcctgggac atctcgatct cgccgccctc     1020

tcgcaatggc ccgcgctgct ctggatagga gtctgctcca aaagatacct gcagatgccg     1080

atatgggtgt ttgtcacggc gcccatcagt gttgccctcg gctttgtgct cgcatgcgat     1140

tcgtggatac acaatgcgcg caacacgacc atttggtcgt ag                        1182


<210>   35
<211>   384
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   35
Met Ala Ser Glu Arg Thr Val Ile Val Phe Phe Ala Gly Asn Glu Val 
                5                   10                  15      

Gly Gly Ala Ala Thr His Leu Ala Thr Trp Ala Lys Ala Leu Lys Gly 
            20                  25                  30          

Ala Gln Val Asp Tyr Arg Tyr Arg Phe Val Ser Leu Gly Asp Gly Pro 
        35                  40                  45              

Leu Ala Asp Glu Leu Arg Gln Met Gly Met Leu His Gly Ala Val Ala 
    50                  55                  60                  

Gly Thr Val Gly Ala Ile Arg Asp Leu Ala Arg Val Leu Arg Arg Glu 
65                  70                  75                  80  

Arg Ala Trp Ile Leu His Ser His Gly Pro Arg Met Asn Met Leu Ala 
                85                  90                  95      

Ser Phe Ala Ala Ser Ser Ala Gly Ala Ile Trp Thr Ala Thr Ile His 
            100                 105                 110         

Ser His Pro Arg Tyr Asp Phe Glu Gly His Pro Leu Lys Ala Ala Leu 
        115                 120                 125             

Phe Pro Ser Leu His Leu Trp Arg Leu Ser Arg Ala Arg Gly Leu Phe 
    130                 135                 140                 

Val Val Gln Pro Ala Leu Gly Asp Ala Leu Pro Cys Arg Thr Ile Leu 
145                 150                 155                 160 

Glu Val Pro Asn Ala Phe Phe Pro Arg Leu Pro Arg Ala Ser Arg Asp 
                165                 170                 175     

Val Cys Ala Ala Glu Trp Arg Arg Arg Leu Gly Leu Asn Pro Glu Ser 
            180                 185                 190         

Arg Leu Ile Gly Ile Ala Ala Arg Leu Asp Pro Val Lys Gln Ile Asp 
        195                 200                 205             

Val Ala Ile Ala Ala Leu Ala Leu Leu Ser Asp Leu Asp Val His Leu 
    210                 215                 220                 

Leu Val Ala Gly Asp Gly Arg Asp Arg Ile Arg Leu Glu Ala Ala Ala 
225                 230                 235                 240 

Glu Asp Cys Gly Val Arg His Arg Val His Phe Leu Gly His Leu Gln 
                245                 250                 255     

Asp Val Arg Asp Leu Tyr Cys Ala Ile Asp Val His Val Leu Pro Ser 
            260                 265                 270         

Lys Ser Glu Gly Ala Pro Thr Ser Met Leu Glu Ala Gly Tyr Tyr Gly 
        275                 280                 285             

Ala Ala Asn Ile Gly Ser Asp Val Pro Gly Ile Arg Arg Met Leu Leu 
    290                 295                 300                 

Asp Gly Glu Ala Gly Ala Leu Val Pro Ser Gly Asp Val Gln Ala Leu 
305                 310                 315                 320 

Ala His Ala Val Arg Arg Leu Leu Thr Asp Thr Lys Ala Arg Asp Ala 
                325                 330                 335     

Tyr Val Glu Arg Phe Gln Arg Leu Val Leu Pro Arg Tyr Arg Pro Glu 
            340                 345                 350         

Arg Met Val Val Ala Tyr Glu Arg Gly Tyr Thr Val Ile Glu Glu Asp 
        355                 360                 365             

Ala Val Arg Ser Gly Trp Arg Leu Pro Ala Asn Ser Glu Gln Thr Arg 
    370                 375                 380                 

<210>   36
<211>   1155
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   36
ttggcttcgg agcgcaccgt gatcgtattt tttgcgggaa acgaagtggg gggcgctgcg       60

acgcacctcg cgacctgggc gaaggcgctg aagggcgcgc aggtcgacta ccgctaccgc      120

tttgtcagct tgggcgacgg accgcttgcg gacgaactgc ggcagatggg gatgttgcac      180

ggcgcggtcg cagggacggt tggcgccata cgcgatttgg ctcgtgtgct ccgacgcgag      240

cgcgcgtgga ttctccactc gcacggaccg cgcatgaata tgctcgcatc gttcgccgca      300

tcgagtgcgg gggccatctg gaccgctacg attcacagcc atcctcgata cgacttcgag      360

gggcacccct tgaaagccgc cttgtttccc agcctccatc tgtggcgcct gtctcgtgcg      420

cgcggcctgt ttgtggttca gcccgcgctc ggagacgccc ttccctgccg gaccatcctc      480

gaggttccca atgcgttttt tccgcggcta cccagggctt cgcgcgacgt gtgcgcagcc      540

gaatggcgac gtcggctggg cctgaaccca gaatcgaggc tgatcggcat cgcggcccgg      600

ctcgatccgg tcaaacagat cgacgtcgcc atcgccgccc tggcgcttct ctcagacctg      660

gacgttcatc tgcttgtcgc gggcgacggg cgagatcgta tccggttaga agcggcagcg      720

gaggactgcg gcgtgcgcca tcgggttcac tttttggggc atttgcagga tgtgcgcgat      780

ttgtattgcg ccatcgacgt ccacgtgttg ccctcgaaga gcgaaggagc tcccacctcc      840

atgttggagg ccggttatta cggggccgcg aacatcgggt cggacgtacc gggcattcgg      900

cggatgctgc tcgacggaga ggctggcgcg cttgtgccgt ctggcgatgt gcaggccctt      960

gctcatgcgg tgcggcgact tctcacggac accaaggcgc gggacgccta cgtggaacgg     1020

tttcagcggc tcgtgcttcc gaggtatagg ccggaacgca tggtcgtcgc gtacgagcgc     1080

ggctacacgg taatcgagga agatgcggtg cgaagtggct ggaggcttcc ggcgaactct     1140

gaacagacga ggtga                                                      1155


<210>   37
<211>   359
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   37
Val Leu His Val Ile Ser Gly Gly Glu Thr Gly Gly Ser Arg Lys His 
                5                   10                  15      

Val Val Thr Leu Leu Ser Lys Phe Ala Pro Gly Thr Ala Thr Leu Val 
            20                  25                  30          

Val Phe Gln Asp Gly Pro Leu Ala Ala Glu Ala Arg Gln Ala Gly Ile 
        35                  40                  45              

Asp Val Arg Leu Leu Ala Gln Ser Ser Arg Tyr Asp Leu Ser Val Leu 
    50                  55                  60                  

Ser Lys Leu Val Ala Leu Ile Arg Arg Glu Arg Phe Asp Ile Leu His 
65                  70                  75                  80  

Thr His Gly Pro Arg Ala Asn Leu Tyr Gly Ala Leu Ile Lys Arg Lys 
                85                  90                  95      

Ile Ala Ile Pro Trp Met Thr Thr Val His Ser Asp Pro Arg Leu Asp 
            100                 105                 110         

Phe Met Lys Ser Gly Trp Lys Gly Lys Trp Phe Thr Arg Leu Asn Val 
        115                 120                 125             

Trp Ala Leu Gln Lys Val Asp Tyr Phe Phe Ala Val Ser Glu Arg Phe 
    130                 135                 140                 

Lys Glu Ser Leu Met Glu Leu Gly Ile Ala Ala Glu Arg Ile Gln Thr 
145                 150                 155                 160 

Ile Tyr Asn Gly Ile Asp Phe Asp Asp Ala Pro Arg Pro His Met Leu 
                165                 170                 175     

Gln Arg Ala Asp Leu Gly Leu Arg Glu Asp Asp Leu Val Ile Ala Met 
            180                 185                 190         

Val Ala Arg Leu His Pro Ile Lys Gly His Ala Leu Val Phe Glu Ala 
        195                 200                 205             

Leu Ala Ser Leu Ser Asp Pro Asp Met Lys Leu Leu Val Val Gly Asp 
    210                 215                 220                 

Gly Pro Leu Ala Ser Glu Leu Arg Glu Lys Ala Thr Gln Ser Gly Ile 
225                 230                 235                 240 

Gly Arg Gln Val Gln Phe Leu Gly Phe Arg Arg Asp Val Ala Asp Ile 
                245                 250                 255     

Tyr Ala Leu Ser Asp Val Ala Leu Met Ala Ser Tyr Ser Glu Ser Phe 
            260                 265                 270         

Pro Leu Ala Leu Leu Glu Ala Ala Asn Glu Arg Leu Pro Val Ile Ser 
        275                 280                 285             

Thr Asp Val Gly Gly Val Ser Gln Leu Ile Ala Ser Ser Asp Met Gly 
    290                 295                 300                 

Trp Ile Val Pro Val Gly Asp Arg Ala Ala Leu Ala Gln Ala Met Arg 
305                 310                 315                 320 

Glu Ala Arg Ser Arg Arg His Glu Leu Lys Thr Met Gly Lys Arg Leu 
                325                 330                 335     

Tyr Glu His Ala Ser Thr His Phe Ser Leu Gln Arg Leu Tyr Glu Glu 
            340                 345                 350         

Thr Met Ala Thr Tyr Glu Arg 
        355                 

<210>   38
<211>   367
<212>   PRT
<213>   Bacteroides capillosus ATCC 29799

<400>   38
Val Ile His Leu Ile Ser Gly Gly Asp Ser Gly Gly Ala Lys Thr His 
                5                   10                  15      

Val His Met Leu Leu Gln Asn Leu Ser Arg Thr Pro Gly Val Glu Val 
            20                  25                  30          

Thr Met Val Cys Phe Met Glu Gly Pro Phe Ser Gln Glu Ala Arg Glu 
        35                  40                  45              

Leu Gly Ile Ser Thr Val Val Leu Pro Gly Lys Asn Ile Phe Arg Thr 
    50                  55                  60                  

Phe His Thr Leu Lys Asn Met Ile Arg Glu Gly Gly Tyr Glu Ile Ile 
65                  70                  75                  80  

His Cys His Gly Ala Arg Gly Asn Met Met Gly Ala Leu Leu Arg Lys 
                85                  90                  95      

Ala Thr Gly Leu Pro Val Val Thr Thr Val His Ser Asp Tyr Arg Leu 
            100                 105                 110         

Asp Tyr Met Gly Arg Pro Ile Ser Arg Ile Thr Tyr Gly Thr Ile Asn 
        115                 120                 125             

Thr Leu Ala Leu Arg Leu Leu Asp Tyr Arg Ile Gly Val Ser Asp Ala 
    130                 135                 140                 

Met Thr Asp Leu Leu Ile Ser Arg Gly Phe Asp Pro Asp Lys Leu Phe 
145                 150                 155                 160 

Thr Ile Tyr Asn Gly Ile Asp Phe Thr Pro Arg Thr Pro Ser Met Thr 
                165                 170                 175     

Arg Ser Glu Tyr Leu Lys Ser Val Gly Ala Asn Trp Pro Glu Asp Cys 
            180                 185                 190         

Val Val Ala Gly Ile Ala Ala Arg Leu Asn Pro Val Lys Asp Ile Pro 
        195                 200                 205             

Thr Leu Ile Arg Gly Phe Ala Gln Ala Arg Gln Ser Cys Pro Lys Leu 
    210                 215                 220                 

Arg Leu Leu Ile Ala Gly Asp Gly Glu Gln Met Asn Glu Leu Lys Ala 
225                 230                 235                 240 

Leu Ala Ala Asp Leu Gly Val Ala Glu Asp Val Cys Phe Ala Gly Trp 
                245                 250                 255     

Val Ser Asp Val Asp Ser Phe Tyr Gly Ala Leu Asp Ile Asn Thr Leu 
            260                 265                 270         

Thr Ser Leu Ser Glu Thr Phe Pro Tyr Ser Leu Thr Glu Gly Ala Arg 
        275                 280                 285             

Ala Gly Leu Pro Thr Val Ala Ser Arg Val Gly Gly Val Pro Tyr Leu 
    290                 295                 300                 

Ile Asp His Gly Val Asn Gly Leu Leu Phe Glu Ala Gly Asp Tyr Glu 
305                 310                 315                 320 

Thr Leu Ala Lys His Leu Thr Ala Leu Ala Ser Asp Glu Thr Met Arg 
                325                 330                 335     

Thr His Met Gly Gln Arg Leu Tyr Gln Lys Gly Lys Asn Asp Tyr Ser 
            340                 345                 350         

Leu Glu Ser Thr Leu Gln Arg Gln Leu Glu Ile Tyr Ser Val Ile 
        355                 360                 365         

<210>   39
<211>   314
<212>   PRT
<213>   Bacillus weihenstephanensis KBAB4

<400>   39
Ala Gly Ala Glu Asp Gly Gly Gly Lys Thr His Ile Ile Ser Leu Leu 
                5                   10                  15      

Asp Gln Phe Pro Asp Gly Glu Val Glu Leu Ala Val Phe Glu Asp Gly 
            20                  25                  30          

Ile Val Ala Lys Glu Ala Arg Glu Leu Gly Ile Lys Val His Val Phe 
        35                  40                  45              

Ser Gln Lys Ser Arg Tyr Asp Leu Ser Ile Leu Lys Asn Ile Ser Glu 
    50                  55                  60                  

Phe Ile Asn Lys Glu Lys Phe Asp Val Val His Thr His Gly Pro Arg 
65                  70                  75                  80  

Ala Asn Phe Phe Val Ser Leu Met Lys Lys Lys Phe Ala Ala Lys Trp 
                85                  90                  95      

Val Thr Thr Ile His Ser Asp Pro Phe Gln Asp Phe Thr Lys Gln Gly 
            100                 105                 110         

Leu Lys Gly Trp Ile Phe Thr Lys Leu Asn Leu Lys Ala Leu Lys Asn 
        115                 120                 125             

Ile Asp Leu Phe Phe Val Val Thr Asn Arg Leu Lys Lys Ser Leu Ala 
    130                 135                 140                 

Ala Leu Gly Ile Ser Asn Glu Lys Met His Val Ile Tyr Asn Gly Ile 
145                 150                 155                 160 

Glu Tyr Asp Gln Glu Lys Ala Asp Gly Tyr Asn Lys Lys Glu Met Phe 
                165                 170                 175     

Asn Ile Asp Glu Asp Val Phe Thr Ala Ile Gln Val Ala Arg Leu His 
            180                 185                 190         

Pro Val Lys Gly His Glu Val Leu Phe Asp Ala Leu Gln Gln Thr Lys 
        195                 200                 205             

Leu Glu Lys Ile Lys Val Leu Leu Val Gly Asp Gly Pro Leu Glu Arg 
    210                 215                 220                 

Glu Leu Lys Ala Leu Ala Thr Glu Lys Gly Ile Asn Asp Lys Val Glu 
225                 230                 235                 240 

Phe Leu Gly His Arg Gln Asp Val Lys Gln Leu Phe Ala Ser Ser His 
                245                 250                 255     

Val Asn Leu Leu Thr Ser His Ser Glu Gly Phe Pro Leu Val Leu Leu 
            260                 265                 270         

Glu Ala Ala Asn Gln Arg Val Pro Ser Ile Val Thr Arg Ala Gly Glu 
        275                 280                 285             

Ile Glu Pro Leu Ile Ala Asp Glu Thr Tyr Gly Trp Ile Val Pro Thr 
    290                 295                 300                 

Gly Asp Gly Lys Ala Leu Ala Ser Ala Leu 
305                 310                 

<210>   40
<211>   316
<212>   PRT
<213>   Bacillus cereus subsp. cytotoxis NVH 391-98

<400>   40
Ala Gly Ala Glu Asp Gly Gly Gly Lys Thr His Ile Ile Ser Leu Leu 
                5                   10                  15      

Asp Gln Phe Pro Thr Asp Glu Val Glu Leu Ala Val Phe Glu Asp Gly 
            20                  25                  30          

Ile Val Ala Arg Glu Ala Arg Glu Ile Gly Ile Lys Val His Val Phe 
        35                  40                  45              

Ser Gln Lys Ser Arg Tyr Asp Leu Ser Ile Leu Lys Asn Ile Ser Arg 
    50                  55                  60                  

Phe Ile Asn Glu Glu Gln Phe Asp Ile Val His Thr His Gly Pro Arg 
65                  70                  75                  80  

Ala Asn Phe Tyr Val Ser Leu Met Lys Lys Arg Ile Ala Ala Lys Trp 
                85                  90                  95      

Val Thr Thr Ile His Ser Asp Pro Phe Gln Asp Phe Thr Lys Gln Gly 
            100                 105                 110         

Leu Lys Gly Trp Ile Phe Thr Lys Leu Asn Leu Lys Ala Leu Lys Asp 
        115                 120                 125             

Ile Asp Leu Phe Phe Val Val Thr Asn Arg Leu Lys Lys Ser Leu Glu 
    130                 135                 140                 

Gln Leu Gly Ile Ser Ser Glu Lys Met Arg Val Ile Tyr Asn Gly Ile 
145                 150                 155                 160 

Glu Tyr Asp Lys Glu Lys Ala Gln Gly Tyr Asp Lys Lys Glu Lys Phe 
                165                 170                 175     

His Ile Glu Glu Asp Val Phe Thr Ala Ile Gln Val Ala Arg Leu His 
            180                 185                 190         

Pro Val Lys Gly His Glu Val Leu Phe Asp Ala Leu Asn Asn Thr Ser 
        195                 200                 205             

Leu Thr Lys Ile Lys Val Leu Leu Val Gly Asp Gly Pro Leu Glu Glu 
    210                 215                 220                 

Asp Leu Lys Ala Leu Ala Lys Glu Lys Gly Ile Asp Asp Lys Val Gln 
225                 230                 235                 240 

Phe Leu Gly His Arg Gln Asp Val Lys Gln Leu Phe Ala Ser Ala His 
                245                 250                 255     

Ile Asn Leu Leu Thr Ser His Ser Glu Gly Phe Pro Leu Val Leu Leu 
            260                 265                 270         

Glu Ala Ala Asn Gln Arg Val Pro Ser Ile Val Thr Arg Ala Gly Glu 
        275                 280                 285             

Ile Glu Pro Leu Ile Val Asp Asp Thr Tyr Gly Trp Val Val Pro Val 
    290                 295                 300                 

Gly Asp Gly Lys Ala Leu Ala Asn Ala Leu Glu Gln 
305                 310                 315     

<210>   41
<211>   314
<212>   PRT
<213>   Bacillus cereus ATCC 14579

<400>   41
Ala Gly Ala Glu Asp Gly Gly Gly Lys Thr His Ile Ile Ser Leu Leu 
                5                   10                  15      

Asp Gln Phe Pro Thr Gly Glu Val Glu Leu Ala Val Phe Glu Asp Gly 
            20                  25                  30          

Ile Val Ala Lys Glu Ala Arg Glu Leu Gly Ile Lys Val His Val Phe 
        35                  40                  45              

Ser Gln Lys Ser Arg Tyr Asp Leu Ser Ile Leu Lys Asn Ile Ser Glu 
    50                  55                  60                  

Phe Ile Asn Lys Glu Lys Phe Asp Val Val His Thr His Gly Pro Arg 
65                  70                  75                  80  

Ala Asn Phe Tyr Val Ser Leu Met Lys Lys Arg Ile Lys Ala Lys Trp 
                85                  90                  95      

Val Thr Thr Ile His Ser Asp Pro Phe Gln Asp Phe Thr Lys Gln Gly 
            100                 105                 110         

Leu Lys Gly Trp Ile Phe Thr Lys Leu Asn Leu Lys Ala Leu Lys Asn 
        115                 120                 125             

Ile Asp Leu Phe Phe Val Val Thr Asn Arg Leu Lys Lys Ser Leu Ala 
    130                 135                 140                 

Ala Leu Gly Ile Ser Asn Glu Lys Met His Val Ile Tyr Asn Gly Ile 
145                 150                 155                 160 

Glu Tyr Asp Lys Glu Lys Ala Glu Gly Tyr Asn Lys Lys Glu Met Phe 
                165                 170                 175     

Asn Ile Asp Glu Asp Val Phe Thr Ala Ile Gln Val Ala Arg Leu His 
            180                 185                 190         

Pro Val Lys Gly His Glu Val Leu Phe Asp Ala Leu Gln Gln Thr Lys 
        195                 200                 205             

Leu Glu Lys Ile Lys Val Leu Leu Val Gly Asp Gly Pro Leu Glu Glu 
    210                 215                 220                 

Asn Leu Lys Ser Leu Ala Thr Glu Lys Gly Ile Asn Asp Lys Val Glu 
225                 230                 235                 240 

Phe Leu Gly His Arg Gln Asp Val Lys Gln Leu Phe Ala Ser Ser His 
                245                 250                 255     

Val Asn Leu Leu Thr Ser His Ser Glu Gly Phe Pro Leu Val Leu Leu 
            260                 265                 270         

Glu Ala Ala Asn Gln Arg Val Pro Ser Ile Val Thr Arg Ala Gly Glu 
        275                 280                 285             

Ile Glu Pro Leu Ile Val Asp Glu Thr Tyr Gly Trp Ile Val Pro Thr 
    290                 295                 300                 

Gly Asp Gly Lys Ala Leu Ala Leu Ala Leu 
305                 310                 

<210>   42
<211>   384
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 35

<400>   42
Met Ala Ser Glu Arg Thr Val Ile Val Phe Phe Ala Gly Asn Glu Val 
                5                   10                  15      

Gly Gly Ala Ala Thr His Leu Ala Thr Trp Ala Lys Ala Leu Lys Gly 
            20                  25                  30          

Ala Gln Val Asp Tyr Arg Tyr Arg Phe Val Ser Leu Gly Asp Gly Pro 
        35                  40                  45              

Leu Ala Asp Glu Leu Arg Gln Met Gly Met Leu His Gly Ala Val Ala 
    50                  55                  60                  

Gly Thr Val Gly Ala Ile Lys Asp Leu Ala Arg Val Leu Arg Arg Glu 
65                  70                  75                  80  

Arg Ala Trp Ile Leu His Ser His Gly Pro Arg Met Asn Met Leu Ala 
                85                  90                  95      

Ser Phe Ala Ala Ser Ser Ala Gly Ala Ile Trp Thr Ala Thr Ile His 
            100                 105                 110         

Ser His Pro Arg Tyr Asp Phe Glu Gly His Pro Leu Lys Ala Ala Leu 
        115                 120                 125             

Phe Pro Ser Leu His Leu Trp Arg Leu Ser Arg Ala Arg Gly Leu Phe 
    130                 135                 140                 

Val Val Gln Pro Ala Leu Gly Asp Ala Leu Pro Cys Arg Thr Ile Leu 
145                 150                 155                 160 

Glu Val Pro Asn Ala Phe Phe Pro Arg Leu Pro Arg Ala Ser Arg Asp 
                165                 170                 175     

Val Cys Ala Ala Glu Trp Arg Arg Arg Leu Gly Leu Asn Pro Glu Ser 
            180                 185                 190         

Arg Leu Ile Gly Ile Ala Ala Arg Leu Asp Pro Val Lys Gln Ile Asp 
        195                 200                 205             

Val Ala Ile Ala Ala Leu Ala Leu Leu Ser Asp Leu Asp Val His Leu 
    210                 215                 220                 

Leu Val Ala Gly Asp Gly Arg Asp Arg Ile Arg Leu Glu Ala Ala Ala 
225                 230                 235                 240 

Glu Asp Cys Gly Val Arg His Arg Val His Phe Leu Gly His Leu Gln 
                245                 250                 255     

Asp Val Arg Asp Leu Tyr Cys Ala Ile Asp Val His Val Leu Pro Ser 
            260                 265                 270         

Lys Ser Glu Gly Ala Pro Thr Ser Met Leu Glu Ala Gly Tyr Tyr Gly 
        275                 280                 285             

Ala Ala Asn Ile Gly Ser Asp Val Pro Gly Ile Arg Arg Met Leu Leu 
    290                 295                 300                 

Asp Gly Glu Ala Gly Ala Leu Val Pro Ser Gly Asp Val Gln Ala Leu 
305                 310                 315                 320 

Ala His Ala Val Arg Arg Leu Leu Thr Asp Thr Lys Ala Arg Asp Ala 
                325                 330                 335     

Tyr Val Glu Arg Phe Gln Arg Leu Val Leu Pro Arg Tyr Arg Pro Glu 
            340                 345                 350         

Arg Met Val Val Ala Tyr Glu Arg Gly Tyr Thr Val Ile Glu Glu Asp 
        355                 360                 365             

Ala Val Arg Ser Gly Trp Arg Leu Pro Ala Asn Ser Glu Gln Thr Arg 
    370                 375                 380                 

<210>   43
<211>   384
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 35

<400>   43
Met Ala Ser Glu Arg Thr Val Ile Val Phe Phe Ala Gly Asn Glu Val 
                5                   10                  15      

Gly Gly Ala Ala Thr His Leu Ala Thr Trp Ala Lys Ala Leu Lys Gly 
            20                  25                  30          

Ala Gln Val Asp Tyr Arg Tyr Arg Phe Val Ser Leu Gly Asp Gly Pro 
        35                  40                  45              

Leu Ala Asp Glu Leu Arg Gln Met Gly Met Leu His Gly Ala Val Ala 
    50                  55                  60                  

Gly Thr Val Gly Ala Ile Arg Asp Leu Ala Arg Val Leu Arg Arg Glu 
65                  70                  75                  80  

Arg Ala Trp Ile Leu His Ser His Gly Pro Arg Met Asn Met Leu Ala 
                85                  90                  95      

Ser Phe Ala Ala Ser Ser Ala Gly Ala Ile Trp Thr Ala Thr Ile His 
            100                 105                 110         

Ser His Pro Arg Tyr Asp Phe Glu Gly His Pro Leu Lys Ala Ala Leu 
        115                 120                 125             

Phe Pro Ser Leu His Leu Trp Arg Leu Ser Arg Ala Arg Gly Leu Phe 
    130                 135                 140                 

Val Val Gln Pro Ala Leu Gly Asp Ala Leu Pro Cys Arg Thr Ile Leu 
145                 150                 155                 160 

Glu Val Pro Asn Ala Phe Phe Pro Arg Leu Pro Arg Ala Ser Arg Asp 
                165                 170                 175     

Val Cys Ala Ala Glu Trp Arg Arg Arg Leu Gly Leu Asn Pro Glu Ser 
            180                 185                 190         

Arg Leu Ile Gly Ile Ala Ala Arg Leu Asp Pro Val Lys Gln Ile Asp 
        195                 200                 205             

Val Ala Ile Ala Ala Leu Ala Leu Leu Ser Asp Leu Asp Val His Leu 
    210                 215                 220                 

Leu Val Ala Gly Asp Gly Arg Asp Arg Ile Arg Leu Glu Ala Ala Ala 
225                 230                 235                 240 

Asp Asp Cys Gly Val Arg His Arg Val His Phe Leu Gly His Leu Gln 
                245                 250                 255     

Asp Val Arg Asp Leu Tyr Cys Ala Ile Asp Val His Val Leu Pro Ser 
            260                 265                 270         

Lys Ser Glu Gly Ala Pro Thr Ser Met Leu Glu Ala Gly Tyr Tyr Gly 
        275                 280                 285             

Ala Ala Asn Ile Gly Ser Asp Val Pro Gly Ile Arg Arg Met Leu Leu 
    290                 295                 300                 

Asp Gly Glu Ala Gly Ala Leu Val Pro Ser Gly Asp Val Gln Ala Leu 
305                 310                 315                 320 

Ala His Ala Val Arg Arg Leu Leu Thr Asp Thr Lys Ala Arg Asp Ala 
                325                 330                 335     

Tyr Val Glu Arg Phe Gln Arg Leu Val Leu Pro Arg Tyr Arg Pro Glu 
            340                 345                 350         

Arg Met Val Val Ala Tyr Glu Arg Gly Tyr Thr Val Ile Glu Glu Asp 
        355                 360                 365             

Ala Val Arg Ser Gly Trp Arg Leu Pro Ala Asn Ser Glu Gln Thr Arg 
    370                 375                 380                 

<210>   44
<211>   384
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 35

<400>   44
Met Ala Ser Glu Arg Thr Val Ile Val Phe Phe Ala Gly Asn Glu Val 
                5                   10                  15      

Gly Gly Ala Ala Thr His Leu Ala Thr Trp Ala Lys Ala Leu Lys Gly 
            20                  25                  30          

Ala Gln Val Asp Tyr Arg Tyr Arg Phe Val Ser Leu Gly Asp Gly Pro 
        35                  40                  45              

Leu Ala Asp Glu Leu Arg Gln Met Gly Met Leu His Gly Ala Val Ala 
    50                  55                  60                  

Gly Thr Val Gly Ala Ile Arg Asp Leu Ala Arg Val Leu Arg Arg Glu 
65                  70                  75                  80  

Arg Ala Trp Ile Leu His Ser His Gly Pro Arg Met Asn Met Leu Ala 
                85                  90                  95      

Ser Phe Ala Ala Ser Ser Ala Gly Ala Ile Trp Thr Ala Thr Ile His 
            100                 105                 110         

Ser His Pro Arg Tyr Asp Phe Glu Gly His Pro Leu Lys Ala Ala Leu 
        115                 120                 125             

Phe Pro Ser Leu His Leu Trp Arg Leu Ser Arg Ala Arg Gly Leu Phe 
    130                 135                 140                 

Val Val Gln Pro Ala Leu Gly Asp Ala Leu Pro Cys Arg Thr Ile Leu 
145                 150                 155                 160 

Glu Val Pro Asn Ala Phe Phe Pro Arg Leu Pro Arg Ala Ser Arg Asp 
                165                 170                 175     

Val Cys Ala Ala Glu Trp Arg Arg Arg Leu Gly Leu Asn Pro Glu Ser 
            180                 185                 190         

Arg Leu Ile Gly Ile Ala Ala Arg Leu Asp Pro Val Lys Gln Ile Asp 
        195                 200                 205             

Val Ala Ile Ala Ala Leu Ala Leu Leu Ser Asp Leu Asp Val His Leu 
    210                 215                 220                 

Leu Val Ala Gly Asp Gly Arg Asp Arg Ile Arg Leu Glu Ala Ala Ala 
225                 230                 235                 240 

Glu Asp Cys Gly Val Arg His Arg Val His Phe Leu Gly His Leu Gln 
                245                 250                 255     

Asp Val Arg Asp Leu Tyr Cys Ala Ile Asp Val His Val Leu Pro Ser 
            260                 265                 270         

Lys Ser Glu Gly Ala Pro Thr Ser Met Leu Glu Ala Gly Tyr Tyr Gly 
        275                 280                 285             

Ala Ala Asn Ile Gly Ser Asp Val Pro Gly Ile Arg Arg Met Leu Leu 
    290                 295                 300                 

Asp Gly Glu Ala Gly Ala Leu Val Pro Ser Gly Asp Val Gln Ala Leu 
305                 310                 315                 320 

Ala His Ala Val Arg Arg Leu Leu Thr Asp Thr Lys Ala Arg Asp Ala 
                325                 330                 335     

Tyr Val Glu Arg Phe Gln Arg Leu Val Leu Pro Arg Tyr Arg Pro Glu 
            340                 345                 350         

Arg Met Val Val Ala Tyr Glu Arg Gly Tyr Thr Val Ile Glu Glu Glu 
        355                 360                 365             

Ala Val Arg Ser Gly Trp Arg Leu Pro Ala Asn Ser Glu Gln Thr Arg 
    370                 375                 380                 

<210>   45
<211>   384
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 35

<400>   45
Met Ala Ser Glu Arg Thr Val Ile Val Phe Phe Ala Gly Asn Glu Val 
                5                   10                  15      

Gly Gly Ala Ala Thr His Leu Ala Thr Trp Ala Lys Ala Leu Lys Gly 
            20                  25                  30          

Ala Gln Val Asp Tyr Arg Tyr Arg Phe Val Ser Leu Gly Asp Gly Pro 
        35                  40                  45              

Leu Ala Asp Glu Leu Arg Gln Met Gly Met Leu His Gly Ala Val Ala 
    50                  55                  60                  

Gly Thr Val Gly Ala Ile Arg Asp Leu Ala Arg Val Leu Arg Arg Glu 
65                  70                  75                  80  

Arg Ala Trp Ile Leu His Ser His Gly Pro Arg Met Asn Met Leu Ala 
                85                  90                  95      

Ser Phe Ala Ala Ser Ser Ala Gly Ala Ile Trp Thr Ala Thr Ile His 
            100                 105                 110         

Ser His Pro Arg Tyr Asp Phe Glu Gly His Pro Leu Lys Ala Ala Leu 
        115                 120                 125             

Phe Pro Ser Leu His Leu Trp Arg Leu Ser Arg Ala Arg Gly Leu Phe 
    130                 135                 140                 

Val Val Gln Pro Ala Leu Gly Asp Ala Leu Pro Cys Arg Thr Ile Leu 
145                 150                 155                 160 

Glu Val Pro Asn Ala Phe Phe Pro Arg Leu Pro Arg Ala Ser Arg Asp 
                165                 170                 175     

Val Cys Ala Ala Glu Trp Arg Arg Arg Leu Gly Leu Asn Pro Glu Ser 
            180                 185                 190         

Arg Leu Ile Gly Ile Ala Ala Arg Leu Asp Pro Val Lys Gln Ile Asp 
        195                 200                 205             

Ile Ala Ile Ala Ala Leu Ala Leu Leu Ser Asp Leu Asp Val His Leu 
    210                 215                 220                 

Leu Val Ala Gly Asp Gly Arg Asp Arg Ile Arg Leu Glu Ala Ala Ala 
225                 230                 235                 240 

Glu Asp Cys Gly Val Arg His Arg Val His Phe Leu Gly His Leu Gln 
                245                 250                 255     

Asp Val Arg Asp Leu Tyr Cys Ala Ile Asp Val His Val Leu Pro Ser 
            260                 265                 270         

Lys Ser Glu Gly Ala Pro Thr Ser Met Leu Glu Ala Gly Tyr Tyr Gly 
        275                 280                 285             

Ala Ala Asn Ile Gly Ser Asp Val Pro Gly Ile Arg Arg Met Leu Leu 
    290                 295                 300                 

Asp Gly Glu Ala Gly Ala Leu Val Pro Ser Gly Asp Val Gln Ala Leu 
305                 310                 315                 320 

Ala His Ala Val Arg Arg Leu Leu Thr Asp Thr Lys Ala Arg Asp Ala 
                325                 330                 335     

Tyr Val Glu Arg Phe Gln Arg Leu Val Leu Pro Arg Tyr Arg Pro Glu 
            340                 345                 350         

Arg Met Val Val Ala Tyr Glu Arg Gly Tyr Thr Val Ile Glu Glu Asp 
        355                 360                 365             

Ala Val Arg Ser Gly Trp Arg Leu Pro Ala Asn Ser Glu Gln Thr Arg 
    370                 375                 380                 

<210>   46
<211>   384
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 35

<400>   46
Met Ala Ser Glu Arg Thr Val Ile Val Phe Phe Ala Gly Asn Glu Val 
                5                   10                  15      

Gly Gly Ala Ala Thr His Leu Ala Thr Trp Ala Lys Ala Leu Lys Gly 
            20                  25                  30          

Ala Gln Val Asp Tyr Arg Tyr Arg Phe Val Ser Leu Gly Asp Gly Pro 
        35                  40                  45              

Leu Ala Asp Glu Leu Arg Gln Met Gly Met Leu His Gly Ala Val Ala 
    50                  55                  60                  

Gly Thr Val Gly Ala Ile Arg Asp Leu Ala Arg Val Leu Arg Arg Glu 
65                  70                  75                  80  

Arg Ala Trp Ile Leu His Ser His Gly Pro Arg Met Asn Met Leu Ala 
                85                  90                  95      

Ser Phe Ala Ala Ser Ser Ala Gly Ala Ile Trp Thr Ala Thr Ile His 
            100                 105                 110         

Ser His Pro Arg Tyr Asp Phe Glu Gly His Pro Leu Lys Ala Ala Leu 
        115                 120                 125             

Phe Pro Ser Leu His Leu Trp Arg Leu Ser Arg Ala Arg Gly Leu Phe 
    130                 135                 140                 

Val Val Gln Pro Ala Leu Gly Asp Ala Leu Pro Cys Arg Thr Ile Ile 
145                 150                 155                 160 

Glu Val Pro Asn Ala Phe Phe Pro Arg Leu Pro Arg Ala Ser Arg Asp 
                165                 170                 175     

Val Cys Ala Ala Glu Trp Arg Arg Arg Leu Gly Leu Asn Pro Glu Ser 
            180                 185                 190         

Arg Leu Ile Gly Ile Ala Ala Arg Leu Asp Pro Val Lys Gln Ile Asp 
        195                 200                 205             

Val Ala Ile Ala Ala Leu Ala Leu Leu Ser Asp Leu Asp Val His Leu 
    210                 215                 220                 

Leu Val Ala Gly Asp Gly Arg Asp Arg Ile Arg Leu Glu Ala Ala Ala 
225                 230                 235                 240 

Glu Asp Cys Gly Val Arg His Arg Val His Phe Leu Gly His Leu Gln 
                245                 250                 255     

Asp Val Arg Asp Leu Tyr Cys Ala Ile Asp Val His Val Leu Pro Ser 
            260                 265                 270         

Lys Ser Glu Gly Ala Pro Thr Ser Met Leu Glu Ala Gly Tyr Tyr Gly 
        275                 280                 285             

Ala Ala Asn Ile Gly Ser Asp Val Pro Gly Ile Arg Arg Met Leu Leu 
    290                 295                 300                 

Asp Gly Glu Ala Gly Ala Leu Val Pro Ser Gly Asp Val Gln Ala Leu 
305                 310                 315                 320 

Ala His Ala Val Arg Arg Leu Leu Thr Asp Thr Lys Ala Arg Asp Ala 
                325                 330                 335     

Tyr Val Glu Arg Phe Gln Arg Leu Val Leu Pro Arg Tyr Arg Pro Glu 
            340                 345                 350         

Arg Met Val Val Ala Tyr Glu Arg Gly Tyr Thr Val Ile Glu Glu Asp 
        355                 360                 365             

Ala Val Arg Ser Gly Trp Arg Leu Pro Ala Asn Ser Glu Gln Thr Arg 
    370                 375                 380                 

<210>   47
<211>   1155
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 36

<400>   47
ttggcttcgg agcgcaccgt gatcgtattt tttgcgggaa acgaagtggg gggcgctgcg       60

acgcacctcg cgacctgggc gaaggcgctg aagggcgcgc aggtcgacta ccgctaccgc      120

tttgtcagct tgggcgacgg accgcttgcg gacgaactgc ggcagatggg gatgttgcac      180

ggcgcggtcg cagggacggt tggcgccata aaagatttgg ctcgtgtgct ccgacgcgag      240

cgcgcgtgga ttctccactc gcacggaccg cgcatgaata tgctcgcatc gttcgccgca      300

tcgagtgcgg gggccatctg gaccgctacg attcacagcc atcctcgata cgacttcgag      360

gggcacccct tgaaagccgc cttgtttccc agcctccatc tgtggcgcct gtctcgtgcg      420

cgcggcctgt ttgtggttca gcccgcgctc ggagacgccc ttccctgccg gaccatcctc      480

gaggttccca atgcgttttt tccgcggcta cccagggctt cgcgcgacgt gtgcgcagcc      540

gaatggcgac gtcggctggg cctgaaccca gaatcgaggc tgatcggcat cgcggcccgg      600

ctcgatccgg tcaaacagat cgacgtcgcc atcgccgccc tggcgcttct ctcagacctg      660

gacgttcatc tgcttgtcgc gggcgacggg cgagatcgta tccggttaga agcggcagcg      720

gaggactgcg gcgtgcgcca tcgggttcac tttttggggc atttgcagga tgtgcgcgat      780

ttgtattgcg ccatcgacgt ccacgtgttg ccctcgaaga gcgaaggagc tcccacctcc      840

atgttggagg ccggttatta cggggccgcg aacatcgggt cggacgtacc gggcattcgg      900

cggatgctgc tcgacggaga ggctggcgcg cttgtgccgt ctggcgatgt gcaggccctt      960

gctcatgcgg tgcggcgact tctcacggac accaaggcgc gggacgccta cgtggaacgg     1020

tttcagcggc tcgtgcttcc gaggtatagg ccggaacgca tggtcgtcgc gtacgagcgc     1080

ggctacacgg taatcgagga agatgcggtg cgaagtggct ggaggcttcc ggcgaactct     1140

gaacagacga ggtga                                                      1155


<210>   48
<211>   1155
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 36

<400>   48
ttggcttcgg agcgcaccgt gatcgtattt tttgcgggaa acgaagtggg gggcgctgcg       60

acgcacctcg cgacctgggc gaaggcgctg aagggcgcgc aggtcgacta ccgctaccgc      120

tttgtcagct tgggcgacgg accgcttgcg gacgaactgc ggcagatggg gatgttgcac      180

ggcgcggtcg cagggacggt tggcgccata cgcgatttgg ctcgtgtgct ccgacgcgag      240

cgcgcgtgga ttctccactc gcacggaccg cgcatgaata tgctcgcatc gttcgccgca      300

tcgagtgcgg gggccatctg gaccgctacg attcacagcc atcctcgata cgacttcgag      360

gggcacccct tgaaagccgc cttgtttccc agcctccatc tgtggcgcct gtctcgtgcg      420

cgcggcctgt ttgtggttca gcccgcgctc ggagacgccc ttccctgccg gaccatcctc      480

gaggttccca atgcgttttt tccgcggcta cccagggctt cgcgcgacgt gtgcgcagcc      540

gaatggcgac gtcggctggg cctgaaccca gaatcgaggc tgatcggcat cgcggcccgg      600

ctcgatccgg tcaaacagat cgacgtcgcc atcgccgccc tggcgcttct ctcagacctg      660

gacgttcatc tgcttgtcgc gggcgacggg cgagatcgta tccggttaga agcggcagcg      720

gatgactgcg gcgtgcgcca tcgggttcac tttttggggc atttgcagga tgtgcgcgat      780

ttgtattgcg ccatcgacgt ccacgtgttg ccctcgaaga gcgaaggagc tcccacctcc      840

atgttggagg ccggttatta cggggccgcg aacatcgggt cggacgtacc gggcattcgg      900

cggatgctgc tcgacggaga ggctggcgcg cttgtgccgt ctggcgatgt gcaggccctt      960

gctcatgcgg tgcggcgact tctcacggac accaaggcgc gggacgccta cgtggaacgg     1020

tttcagcggc tcgtgcttcc gaggtatagg ccggaacgca tggtcgtcgc gtacgagcgc     1080

ggctacacgg taatcgagga agatgcggtg cgaagtggct ggaggcttcc ggcgaactct     1140

gaacagacga ggtga                                                      1155


<210>   49
<211>   1155
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 36

<400>   49
ttggcttcgg agcgcaccgt gatcgtattt tttgcgggaa acgaagtggg gggcgctgcg       60

acgcacctcg cgacctgggc gaaggcgctg aagggcgcgc aggtcgacta ccgctaccgc      120

tttgtcagct tgggcgacgg accgcttgcg gacgaactgc ggcagatggg gatgttgcac      180

ggcgcggtcg cagggacggt tggcgccata cgcgatttgg ctcgtgtgct ccgacgcgag      240

cgcgcgtgga ttctccactc gcacggaccg cgcatgaata tgctcgcatc gttcgccgca      300

tcgagtgcgg gggccatctg gaccgctacg attcacagcc atcctcgata cgacttcgag      360

gggcacccct tgaaagccgc cttgtttccc agcctccatc tgtggcgcct gtctcgtgcg      420

cgcggcctgt ttgtggttca gcccgcgctc ggagacgccc ttccctgccg gaccatcctc      480

gaggttccca atgcgttttt tccgcggcta cccagggctt cgcgcgacgt gtgcgcagcc      540

gaatggcgac gtcggctggg cctgaaccca gaatcgaggc tgatcggcat cgcggcccgg      600

ctcgatccgg tcaaacagat cgacgtcgcc atcgccgccc tggcgcttct ctcagacctg      660

gacgttcatc tgcttgtcgc gggcgacggg cgagatcgta tccggttaga agcggcagcg      720

gaggactgcg gcgtgcgcca tcgggttcac tttttggggc atttgcagga tgtgcgcgat      780

ttgtattgcg ccatcgacgt ccacgtgttg ccctcgaaga gcgaaggagc tcccacctcc      840

atgttggagg ccggttatta cggggccgcg aacatcgggt cggacgtacc gggcattcgg      900

cggatgctgc tcgacggaga ggctggcgcg cttgtgccgt ctggcgatgt gcaggccctt      960

gctcatgcgg tgcggcgact tctcacggac accaaggcgc gggacgccta cgtggaacgg     1020

tttcagcggc tcgtgcttcc gaggtatagg ccggaacgca tggtcgtcgc gtacgagcgc     1080

ggctacacgg taatcgagga agaagcggtg cgaagtggct ggaggcttcc ggcgaactct     1140

gaacagacga ggtga                                                      1155


<210>   50
<211>   1155
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 36

<400>   50
ttggcttcgg agcgcaccgt gatcgtattt tttgcgggaa acgaagtggg gggcgctgcg       60

acgcacctcg cgacctgggc gaaggcgctg aagggcgcgc aggtcgacta ccgctaccgc      120

tttgtcagct tgggcgacgg accgcttgcg gacgaactgc ggcagatggg gatgttgcac      180

ggcgcggtcg cagggacggt tggcgccata cgcgatttgg ctcgtgtgct ccgacgcgag      240

cgcgcgtgga ttctccactc gcacggaccg cgcatgaata tgctcgcatc gttcgccgca      300

tcgagtgcgg gggccatctg gaccgctacg attcacagcc atcctcgata cgacttcgag      360

gggcacccct tgaaagccgc cttgtttccc agcctccatc tgtggcgcct gtctcgtgcg      420

cgcggcctgt ttgtggttca gcccgcgctc ggagacgccc ttccctgccg gaccatcctc      480

gaggttccca atgcgttttt tccgcggcta cccagggctt cgcgcgacgt gtgcgcagcc      540

gaatggcgac gtcggctggg cctgaaccca gaatcgaggc tgatcggcat cgcggcccgg      600

ctcgatccgg tcaaacagat cgacattgcc atcgccgccc tggcgcttct ctcagacctg      660

gacgttcatc tgcttgtcgc gggcgacggg cgagatcgta tccggttaga agcggcagcg      720

gaggactgcg gcgtgcgcca tcgggttcac tttttggggc atttgcagga tgtgcgcgat      780

ttgtattgcg ccatcgacgt ccacgtgttg ccctcgaaga gcgaaggagc tcccacctcc      840

atgttggagg ccggttatta cggggccgcg aacatcgggt cggacgtacc gggcattcgg      900

cggatgctgc tcgacggaga ggctggcgcg cttgtgccgt ctggcgatgt gcaggccctt      960

gctcatgcgg tgcggcgact tctcacggac accaaggcgc gggacgccta cgtggaacgg     1020

tttcagcggc tcgtgcttcc gaggtatagg ccggaacgca tggtcgtcgc gtacgagcgc     1080

ggctacacgg taatcgagga agatgcggtg cgaagtggct ggaggcttcc ggcgaactct     1140

gaacagacga ggtga                                                      1155


<210>   51
<211>   1155
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 36

<400>   51
ttggcttcgg agcgcaccgt gatcgtattt tttgcgggaa acgaagtggg gggcgctgcg       60

acgcacctcg cgacctgggc gaaggcgctg aagggcgcgc aggtcgacta ccgctaccgc      120

tttgtcagct tgggcgacgg accgcttgcg gacgaactgc ggcagatggg gatgttgcac      180

ggcgcggtcg cagggacggt tggcgccata cgcgatttgg ctcgtgtgct ccgacgcgag      240

cgcgcgtgga ttctccactc gcacggaccg cgcatgaata tgctcgcatc gttcgccgca      300

tcgagtgcgg gggccatctg gaccgctacg attcacagcc atcctcgata cgacttcgag      360

gggcacccct tgaaagccgc cttgtttccc agcctccatc tgtggcgcct gtctcgtgcg      420

cgcggcctgt ttgtggttca gcccgcgctc ggagacgccc ttccctgccg gaccatcatt      480

gaggttccca atgcgttttt tccgcggcta cccagggctt cgcgcgacgt gtgcgcagcc      540

gaatggcgac gtcggctggg cctgaaccca gaatcgaggc tgatcggcat cgcggcccgg      600

ctcgatccgg tcaaacagat cgacgtcgcc atcgccgccc tggcgcttct ctcagacctg      660

gacgttcatc tgcttgtcgc gggcgacggg cgagatcgta tccggttaga agcggcagcg      720

gaggactgcg gcgtgcgcca tcgggttcac tttttggggc atttgcagga tgtgcgcgat      780

ttgtattgcg ccatcgacgt ccacgtgttg ccctcgaaga gcgaaggagc tcccacctcc      840

atgttggagg ccggttatta cggggccgcg aacatcgggt cggacgtacc gggcattcgg      900

cggatgctgc tcgacggaga ggctggcgcg cttgtgccgt ctggcgatgt gcaggccctt      960

gctcatgcgg tgcggcgact tctcacggac accaaggcgc gggacgccta cgtggaacgg     1020

tttcagcggc tcgtgcttcc gaggtatagg ccggaacgca tggtcgtcgc gtacgagcgc     1080

ggctacacgg taatcgagga agatgcggtg cgaagtggct ggaggcttcc ggcgaactct     1140

gaacagacga ggtga                                                      1155


<210>   52
<211>   384
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   52
Met Arg Val Gly Ile Ser Cys Tyr Pro Thr Val Gly Gly Ser Gly Ala 
                5                   10                  15      

Val Ala Thr Glu Leu Gly Lys Ala Leu Ala Arg Arg Gly His Glu Val 
            20                  25                  30          

His Phe Ile Val Thr Asp Val Pro Phe Arg Leu Gly Ala Phe Val Glu 
        35                  40                  45              

His Val Tyr Ile His Gln Ile Glu Pro Ile Thr Tyr Pro Val Leu Lys 
    50                  55                  60                  

Thr Pro Pro Tyr Asp Phe Ala Leu Ala Ser Leu Met Ala Arg Val Ala 
65                  70                  75                  80  

Asp Glu Tyr Gln Leu Asp Val Leu His Ala His Tyr Ala Leu Pro Phe 
                85                  90                  95      

Ala Val Cys Ala His Leu Ala Arg Glu Met Ala Lys His Pro Ile Arg 
            100                 105                 110         

Val Val Thr Thr Leu His Gly Thr Asp Ile Thr Val Leu Ala Gln Asp 
        115                 120                 125             

Pro Ser Leu Lys Ser Ile Ile Lys Leu Gly Ile Glu Arg Ser Asp Ala 
    130                 135                 140                 

Val Thr Ala Val Ser Gln Ser Leu Val Arg Asp Thr Ala Arg Leu Phe 
145                 150                 155                 160 

Glu Thr Asp Lys Pro Ile Arg Cys Ile Tyr Asn Phe Val Asp Pro Asp 
                165                 170                 175     

Val Phe Arg Pro Gly Cys Gly Gly Glu Leu Lys Arg His Phe Ala Pro 
            180                 185                 190         

Asn Gly Glu Arg Val Leu Leu His Ile Ser Asn Phe Arg Pro Val Lys 
        195                 200                 205             

Arg Leu His Asp Val Ile Ala Val Phe Glu Arg Val Ala Arg Arg Met 
    210                 215                 220                 

Pro Ala Lys Leu Leu Leu Val Gly Glu Gly Pro Asp Leu Gly Ala Ala 
225                 230                 235                 240 

Lys Arg Gln Val Glu Glu Ala Gly Leu Gly Asp Arg Val His Phe Leu 
                245                 250                 255     

Gly Arg Gln Asp Glu Val Ala Pro Leu Phe Ala Ala Ala Asp Leu Phe 
            260                 265                 270         

Leu Leu Pro Ser Glu Ser Glu Ser Phe Gly Leu Val Ala Leu Glu Ala 
        275                 280                 285             

Met Ser Cys Gly Val Pro Val Val Gly Ser Thr Ala Gly Gly Ile Pro 
    290                 295                 300                 

Glu Val Val Val His Gly Glu Thr Gly Phe Leu Ala Pro Val Gly Arg 
305                 310                 315                 320 

Val Asp Asp Met Ala Asp Leu Ala Cys Lys Leu Leu Gln Asp Glu Ala 
                325                 330                 335     

Thr Tyr Arg Ala Phe Ser Ala Arg Ala Arg Glu Arg Ala Val Arg Ala 
            340                 345                 350         

Phe His Val Asp Glu Lys Val Ser Glu Tyr Glu Ala Leu Tyr Arg Glu 
        355                 360                 365             

Val Met Ala Ala Glu Arg Gly Glu His Ala His Pro Arg Pro Gly Ala 
    370                 375                 380                 

<210>   53
<211>   1155
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   53
ttgcgcgtgg gtatcagctg ttatccgacg gtgggcggat ccggagcggt ggccaccgag       60

cttggcaagg cgctcgcgcg gcggggacac gaggtgcact tcatcgtgac cgacgtgccg      120

ttccggctcg gcgcgtttgt ggaacacgtg tacattcacc aaatcgagcc catcacgtac      180

ccggtcctca agaccccgcc gtacgacttt gcgctcgcca gtctcatggc gcgcgtggcc      240

gatgaatacc aactcgacgt gctgcacgcg cactacgccc ttccgtttgc ggtgtgtgca      300

cacctggcgc gcgagatggc gaagcatccc atccgggtgg tcaccacctt gcatggcacg      360

gacatcacgg tgttggccca ggatccgagc ctcaagtcca tcatcaaact cggcatcgag      420

cgcagcgacg cggtgacggc cgtcagccag agcctggtcc gggacacggc acgcttgttc      480

gagacggaca aaccgattcg ctgcatctac aacttcgtcg atcccgacgt gtttcggccc      540

gggtgcggcg gggaactgaa gcgccacttc gcgccaaacg gcgagcgcgt tctgcttcac      600

atctccaact tccgcccggt caaacggctt cacgacgtga tcgccgtgtt tgagcgcgtg      660

gcgagacgca tgccggcgaa gctgctcctc gtcggcgaag ggccggatct gggagcggcc      720

aaacgccagg tggaggaggc gggtctcggc gatcgcgtgc attttttggg gcgccaggac      780

gaggtggcgc cgctttttgc ggccgccgat ctgttcctgc tgccttccga aagcgagagc      840

ttcggcctcg tcgcgctcga ggcgatgtct tgcggcgtgc ccgttgtcgg atcgacggcc      900

ggcggcattc cggaggtggt tgtgcacggg gagaccggct ttctcgcgcc cgtcggccgc      960

gtcgacgaca tggcggatct cgcctgtaag cttttgcaag acgaggccac gtaccgggcg     1020

ttctccgcgc gagcccgcga gcgagccgtg cgagcgtttc atgtggatga gaaggtcagc     1080

gagtacgagg ctttgtatcg cgaggtgatg gcggctgaac gcggcgagca tgcgcatccc     1140

cgccccggcg cgtga                                                      1155


<210>   54
<211>   370
<212>   PRT
<213>   Paenibacillus larvae subsp. larvae BRL-230010

<400>   54
Leu Lys Ile Gly Ile Thr Cys Tyr Pro Ser Leu Gly Gly Ser Gly Val 
                5                   10                  15      

Val Ala Thr Glu Leu Gly Lys Leu Leu Ala Glu Gln Gly His Glu Val 
            20                  25                  30          

His Phe Ile Ala His Ser Met Pro Phe Arg Leu Gly Arg Phe Asp Lys 
        35                  40                  45              

Asn Val Phe Tyr His Glu Val Glu Val Ser Asp Tyr Tyr Val Phe Lys 
    50                  55                  60                  

Tyr Pro Pro Tyr Asp Leu Ser Leu Ala Ser Lys Leu Ala Gln Val Ala 
65                  70                  75                  80  

Arg Met Gln Glu Leu Asp Leu Leu His Val His Tyr Ala Ile Pro His 
                85                  90                  95      

Ala Val Cys Ala Leu Leu Ala Lys Gln Met Val Gly Asp His Leu Lys 
            100                 105                 110         

Val Val Thr Thr Leu His Gly Thr Asp Ile Thr Val Leu Ala Gln Asp 
        115                 120                 125             

Ala Ser Ile Ser Asn Met Ile Arg Phe Ala Ile Asn Glu Ser Asp Ala 
    130                 135                 140                 

Val Thr Ala Val Ser Glu Asp Leu Ile Arg Glu Thr Arg Gln Thr Leu 
145                 150                 155                 160 

Asp Ile Gln Lys Pro Ile His Lys Ile Tyr Asn Phe Val Asp Lys Arg 
                165                 170                 175     

Met Tyr Tyr Pro Arg Pro Val Glu Asp Leu Lys Arg Glu Val Thr Arg 
            180                 185                 190         

Pro Gly Glu Lys Leu Phe Ile His Ile Ser Asn Phe Arg Pro Val Lys 
        195                 200                 205             

Arg Val His Asp Val Val Gln Ile Phe Ala Arg Val His Arg Glu Ile 
    210                 215                 220                 

Pro Ser Arg Leu Leu Leu Val Gly Glu Gly Leu Glu Leu Ser Arg Ile 
225                 230                 235                 240 

Val Ser Glu Val Arg Glu Leu Gly Leu Gln Asp Phe Val Glu Phe Trp 
                245                 250                 255     

Gly Lys Gln Asp Asp Val Ala Gln Val Ile Ser Leu Ala Asp Val Met 
            260                 265                 270         

Leu Leu Pro Ser Glu Lys Glu Ser Phe Gly Leu Val Ala Leu Glu Ala 
        275                 280                 285             

Met Ala Cys Gly Val Pro Thr Val Gly Ser Asn Ala Gly Gly Ile Pro 
    290                 295                 300                 

Glu Leu Ile Thr His Gly Glu Thr Gly Phe Met Ala Glu Val Gly Asp 
305                 310                 315                 320 

Val Asp Thr Met Ser Lys Tyr Thr Ile Arg Leu Leu Glu Asp Glu Glu 
                325                 330                 335     

Leu Leu Lys Arg Val Ser Glu Ala Cys Val Gln Arg Ala Arg Lys Lys 
            340                 345                 350         

Phe Cys Asn Asp Ser Leu Arg Ala Arg Tyr Glu Gln Val Tyr Tyr Glu 
        355                 360                 365             

Val Leu 
    370 

<210>   55
<211>   374
<212>   PRT
<213>   Bacillus pumilus SAFR-032

<400>   55
Leu Lys Val Gly Ile Thr Cys Tyr Pro Ser Val Gly Gly Ser Gly Ile 
                5                   10                  15      

Ile Ala Thr Glu Leu Gly Lys Arg Leu Ala Glu Lys Gly His Asp Val 
            20                  25                  30          

His Phe Ile Thr Ser Ser Ile Pro Phe Arg Leu Asn Lys Val Tyr Pro 
        35                  40                  45              

Asn Ile Tyr Phe His Glu Val Asp Val Asn Gln Tyr Ala Val Phe Gln 
    50                  55                  60                  

Tyr Pro Pro Tyr Asp Leu Ala Leu Ala Ser Lys Leu Ala Glu Val Ala 
65                  70                  75                  80  

Arg Arg Glu Lys Leu Asp Ile Ile His Ala His Tyr Ala Val Pro His 
                85                  90                  95      

Ala Val Cys Ala Tyr Leu Ala Lys Gln Met Thr Gly His Ser Val Lys 
            100                 105                 110         

Val Val Thr Thr Leu His Gly Thr Asp Ile Thr Val Leu Gly Tyr Asp 
        115                 120                 125             

Pro Ser Leu Lys Glu Val Ile Arg Phe Ala Ile Glu Ser Ser Asp Arg 
    130                 135                 140                 

Val Thr Ala Val Ser His Ser Leu Ala Ala Gln Thr Tyr Asp Leu Ile 
145                 150                 155                 160 

Lys Pro Asn Lys Lys Ile Glu Thr Ile His Asn Phe Val Asp Glu Arg 
                165                 170                 175     

Val Tyr Leu Arg Asp Asp His Asn Val Leu Lys Arg His Tyr Gly Leu 
            180                 185                 190         

Leu Asp His Glu Lys Val Val Ile His Val Ser Asn Phe Arg Lys Val 
        195                 200                 205             

Lys Arg Val His Asp Val Ile His Val Phe Lys Lys Ile Ser Glu Gln 
    210                 215                 220                 

Val Asn Ala Lys Leu Leu Leu Ile Gly Asp Gly Pro Glu Lys Ser Val 
225                 230                 235                 240 

Val Cys Glu Leu Val Lys Lys Leu Gly Leu Thr Asp Arg Val Leu Phe 
                245                 250                 255     

Leu Gly Lys Gln Glu Lys Val Glu Glu Leu Tyr Ser Ile Ser Asp Leu 
            260                 265                 270         

Lys Leu Leu Leu Ser Glu Lys Glu Ser Phe Gly Leu Val Leu Leu Glu 
        275                 280                 285             

Ala Met Ala Cys Gly Val Pro Cys Ile Gly Thr Asp Val Gly Gly Ile 
    290                 295                 300                 

Pro Glu Val Ile Thr His Gly Glu Thr Gly Phe Leu Val Pro Leu Gly 
305                 310                 315                 320 

Asp Ile Asp Ala Ala Ala Lys His Ala Val Ser Ile Leu Lys Asp Lys 
                325                 330                 335     

Ala Leu His Glu Gln Val Ser Ala Ala Ala Gln Ser Ser Val Gln Ala 
            340                 345                 350         

His Phe Ser Ser Glu Lys Ile Val Ser Glu Tyr Glu Glu Leu Tyr Leu 
        355                 360                 365             

Glu Leu Ile Glu Gly Asp 
    370                 

<210>   56
<211>   371
<212>   PRT
<213>   Bacillus sp. NRRL B-14911

<400>   56
Leu Lys Ile Gly Ile Thr Cys Tyr Pro Thr Val Gly Gly Ser Gly Val 
                5                   10                  15      

Val Ala Thr Glu Leu Gly Lys Leu Leu Ala Glu Arg Gly His Glu Ile 
            20                  25                  30          

His Phe Ile Ser Ser Ser Leu Pro Phe Arg Leu Asn Arg Met Tyr His 
        35                  40                  45              

Asn Ile Phe Tyr His Gln Val Glu Val Ser Gln Tyr Ser Val Phe Gln 
    50                  55                  60                  

Tyr Pro Pro Tyr Asp Ile Ala Leu Ala Ser Lys Met Ala Glu Val Ile 
65                  70                  75                  80  

Asn Arg Glu Lys Leu Asp Leu Met His Val His Tyr Ala Val Pro His 
                85                  90                  95      

Ala Val Cys Ala Ile Leu Ala Lys Gln Met Ser Gly Arg Asp Val Lys 
            100                 105                 110         

Ile Ala Thr Thr Leu His Gly Thr Asp Ile Thr Val Leu Gly Tyr Glu 
        115                 120                 125             

Pro Ser Leu Lys Asp Ser Ile Arg Phe Gly Ile Glu Lys Ser Asp Arg 
    130                 135                 140                 

Val Thr Ala Val Ser Lys Ser Leu Ile Ser Gln Thr Asn Glu Leu Ile 
145                 150                 155                 160 

His Pro Glu Lys Glu Ile Gln Ala Val Tyr Asn Phe Ile Asp His Arg 
                165                 170                 175     

Val Tyr Gln Lys Thr Gly Ser Asp His Leu Lys Lys Glu Tyr Gly Ile 
            180                 185                 190         

Thr Glu Asp Glu Lys Thr Val Ile His Val Ser Asn Phe Arg Ala Val 
        195                 200                 205             

Lys Arg Val Gln Asp Val Val Lys Val Phe Ala Arg Ile Glu Ser Glu 
    210                 215                 220                 

Met Pro Ala Lys Leu Leu Leu Val Gly Asp Gly Pro Glu Met Ser Asn 
225                 230                 235                 240 

Val Cys Lys Leu Val Lys Glu Leu Gly Leu Lys Glu Lys Val Leu Phe 
                245                 250                 255     

Leu Gly Lys Gln Asp Lys Val Glu Glu Leu Tyr Ser Ile Ser Asp Leu 
            260                 265                 270         

Met Leu Leu Leu Ser Glu Lys Glu Ser Phe Gly Leu Val Ala Leu Glu 
        275                 280                 285             

Ala Met Ala Cys Gly Val Pro Cys Ile Gly Thr Asn Ile Gly Gly Ile 
    290                 295                 300                 

Pro Glu Val Ile Ser Asp Gly Glu Thr Gly Tyr Ile Cys Lys Leu Gly 
305                 310                 315                 320 

Asp Ile Gly Ser Met Ala Glu Lys Ala Ala Gly Leu Leu Ala Asp Ala 
                325                 330                 335     

Asp Lys His Thr Ser Phe Ser His Arg Ala Val Gln Thr Ala Arg Glu 
            340                 345                 350         

Lys Phe Ser Ala Glu Gln Ile Val Ser Glu Tyr Glu Arg Leu Tyr Phe 
        355                 360                 365             

Asp Met Leu 
    370     

<210>   57
<211>   375
<212>   PRT
<213>   Bacillus cereus ATCC 14579

<400>   57
Leu Lys Ile Gly Ile Thr Cys Tyr Pro Ser Val Gly Gly Ser Gly Val 
                5                   10                  15      

Val Gly Thr Glu Leu Gly Lys Gln Leu Ala Glu Arg Gly His Glu Ile 
            20                  25                  30          

His Phe Ile Thr Ser Gly Leu Pro Phe Arg Leu Asn Lys Val Tyr Pro 
        35                  40                  45              

Asn Ile Tyr Phe His Glu Val Thr Val Asn Gln Tyr Ser Val Phe Gln 
    50                  55                  60                  

Tyr Pro Pro Tyr Asp Leu Ala Leu Ala Ser Lys Met Ala Glu Val Ala 
65                  70                  75                  80  

Gln Arg Glu Asn Leu Asp Ile Leu His Val His Tyr Ala Ile Pro His 
                85                  90                  95      

Ala Ile Cys Ala Tyr Leu Ala Lys Gln Met Ile Gly Glu Arg Ile Lys 
            100                 105                 110         

Ile Val Thr Thr Leu His Gly Thr Asp Ile Thr Val Leu Gly Ser Asp 
        115                 120                 125             

Pro Ser Leu Asn Asn Leu Ile Arg Phe Gly Ile Glu Gln Ser Asp Val 
    130                 135                 140                 

Val Thr Ala Val Ser His Ser Leu Ile Asn Glu Thr His Glu Leu Val 
145                 150                 155                 160 

Lys Pro Ser Lys Glu Ile Gln Thr Val Tyr Asn Phe Ile Asp Glu Arg 
                165                 170                 175     

Val Tyr Phe Lys Arg Asn Met Ser Gln Leu Lys Lys Glu Tyr Gly Ile 
            180                 185                 190         

Ser Glu Ser Glu Lys Val Leu Ile His Ile Ser Asn Phe Arg Lys Val 
        195                 200                 205             

Lys Arg Val Gln Asp Val Val Gln Ala Phe Ala Lys Ile Val Lys Glu 
    210                 215                 220                 

Val Asp Ala Lys Leu Leu Leu Val Gly Asp Gly Pro Glu Phe Cys Thr 
225                 230                 235                 240 

Ile Leu Gln Ile Val Lys Asn Leu His Ile Glu Asp Arg Val Leu Phe 
                245                 250                 255     

Leu Gly Lys Gln Asp Asn Val Ala Glu Leu Leu Ala Met Ser Asp Leu 
            260                 265                 270         

Met Leu Leu Leu Ser Glu Lys Glu Ser Phe Gly Leu Val Leu Leu Glu 
        275                 280                 285             

Ala Met Ala Cys Gly Val Pro Cys Ile Gly Thr Arg Val Gly Gly Ile 
    290                 295                 300                 

Pro Glu Val Ile Gln His Gly Glu Thr Gly Tyr Leu Cys Glu Val Gly 
305                 310                 315                 320 

Asp Thr Thr Gly Val Ala Asn Gln Ala Ile Gln Leu Leu Lys Asp Glu 
                325                 330                 335     

Glu Leu His Arg Asn Met Gly Glu Arg Ala Arg Glu Ser Val Tyr Glu 
            340                 345                 350         

Gln Phe Arg Ser Glu Lys Ile Val Ser Gln Tyr Glu Thr Ile Tyr Tyr 
        355                 360                 365             

Asp Val Leu Arg Asp Asp Lys 
    370                 375 

<210>   58
<211>   375
<212>   PRT
<213>   Bacillus anthracis str. Ames

<400>   58
Leu Lys Ile Gly Ile Thr Cys Tyr Pro Ser Val Gly Gly Ser Gly Val 
                5                   10                  15      

Val Gly Thr Glu Leu Gly Lys Gln Leu Ala Glu Arg Gly His Glu Ile 
            20                  25                  30          

His Phe Ile Thr Ser Gly Leu Pro Phe Arg Leu Asn Lys Val Tyr Pro 
        35                  40                  45              

Asn Ile Tyr Phe His Glu Val Thr Val Asn Gln Tyr Ser Val Phe Gln 
    50                  55                  60                  

Tyr Pro Pro Tyr Asp Leu Ala Leu Ala Ser Lys Met Ala Glu Val Ala 
65                  70                  75                  80  

Gln Arg Glu Asn Leu Asp Ile Leu His Val His Tyr Ala Ile Pro His 
                85                  90                  95      

Ala Ile Cys Ala Tyr Leu Ala Lys Gln Met Ile Gly Glu Arg Ile Lys 
            100                 105                 110         

Ile Val Thr Thr Leu His Gly Thr Asp Ile Thr Val Leu Gly Ser Asp 
        115                 120                 125             

Pro Ser Leu Asn Asn Leu Ile Arg Phe Gly Ile Glu Gln Ser Asp Val 
    130                 135                 140                 

Val Thr Ala Val Ser His Ser Leu Ile Asn Glu Thr His Glu Leu Val 
145                 150                 155                 160 

Lys Pro Asn Lys Asp Ile Gln Thr Val Tyr Asn Phe Ile Asp Glu Arg 
                165                 170                 175     

Val Tyr Phe Lys Arg Asp Met Thr Gln Leu Lys Lys Glu Tyr Gly Ile 
            180                 185                 190         

Ser Glu Ser Glu Lys Ile Leu Ile His Ile Ser Asn Phe Arg Lys Val 
        195                 200                 205             

Lys Arg Val Gln Asp Val Val Gln Ala Phe Ala Lys Ile Val Thr Glu 
    210                 215                 220                 

Val Asp Ala Lys Leu Leu Leu Val Gly Asp Gly Pro Glu Phe Cys Thr 
225                 230                 235                 240 

Ile Leu Gln Leu Val Lys Asn Leu His Ile Glu Asp Arg Val Leu Phe 
                245                 250                 255     

Leu Gly Lys Gln Asp Asn Val Ala Glu Leu Leu Ala Met Ser Asp Leu 
            260                 265                 270         

Met Leu Leu Leu Ser Glu Lys Glu Ser Phe Gly Leu Val Leu Leu Glu 
        275                 280                 285             

Ala Met Ala Cys Gly Val Pro Cys Ile Gly Thr Arg Val Gly Gly Ile 
    290                 295                 300                 

Pro Glu Val Ile Gln His Gly Asp Thr Gly Tyr Leu Cys Glu Val Gly 
305                 310                 315                 320 

Asp Thr Thr Gly Val Ala Asp Gln Ala Ile Gln Leu Leu Lys Asp Glu 
                325                 330                 335     

Glu Leu His Arg Asn Met Gly Glu Arg Ala Arg Glu Ser Val Tyr Glu 
            340                 345                 350         

Gln Phe Arg Ser Glu Lys Ile Val Ser Gln Tyr Glu Thr Ile Tyr Tyr 
        355                 360                 365             

Asp Val Leu Arg Asp Asp Lys 
    370                 375 

<210>   59
<211>   384
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 52

<400>   59
Met Arg Val Gly Ile Ser Cys Tyr Pro Thr Val Gly Gly Ser Gly Ala 
                5                   10                  15      

Val Ala Thr Glu Leu Gly Lys Ala Leu Ala Arg Arg Gly His Glu Val 
            20                  25                  30          

His Phe Ile Val Thr Asp Val Pro Phe Arg Leu Gly Ala Phe Val Glu 
        35                  40                  45              

His Val Tyr Ile His Gln Ile Glu Pro Ile Thr Tyr Pro Val Leu Lys 
    50                  55                  60                  

Thr Pro Pro Tyr Asp Phe Ala Leu Ala Ser Leu Met Ala Arg Val Ala 
65                  70                  75                  80  

Asp Glu Tyr Gln Leu Asp Val Leu His Ala His Tyr Ala Leu Pro Phe 
                85                  90                  95      

Ala Val Cys Ala His Leu Ala Arg Glu Met Ala Lys His Pro Ile Arg 
            100                 105                 110         

Val Val Thr Thr Leu His Gly Thr Asp Ile Thr Val Leu Ala Gln Asp 
        115                 120                 125             

Pro Ser Leu Lys Ser Ile Ile Lys Leu Gly Ile Glu Arg Ser Asp Ala 
    130                 135                 140                 

Val Thr Ala Val Ser Gln Ser Leu Val Arg Asp Thr Ala Arg Leu Phe 
145                 150                 155                 160 

Glu Thr Asp Lys Pro Ile Arg Cys Ile Tyr Asn Phe Val Asp Pro Asp 
                165                 170                 175     

Val Phe Arg Pro Gly Cys Gly Gly Asp Leu Lys Arg His Phe Ala Pro 
            180                 185                 190         

Asn Gly Glu Arg Val Leu Leu His Ile Ser Asn Phe Arg Pro Val Lys 
        195                 200                 205             

Arg Leu His Asp Val Ile Ala Val Phe Glu Arg Val Ala Arg Arg Met 
    210                 215                 220                 

Pro Ala Lys Leu Leu Leu Val Gly Glu Gly Pro Asp Leu Gly Ala Ala 
225                 230                 235                 240 

Lys Arg Gln Val Glu Glu Ala Gly Leu Gly Asp Arg Val His Phe Leu 
                245                 250                 255     

Gly Arg Gln Asp Glu Val Ala Pro Leu Phe Ala Ala Ala Asp Leu Phe 
            260                 265                 270         

Leu Leu Pro Ser Glu Ser Glu Ser Phe Gly Leu Val Ala Leu Glu Ala 
        275                 280                 285             

Met Ser Cys Gly Val Pro Val Val Gly Ser Thr Ala Gly Gly Ile Pro 
    290                 295                 300                 

Glu Val Val Val His Gly Glu Thr Gly Phe Leu Ala Pro Val Gly Arg 
305                 310                 315                 320 

Val Asp Asp Met Ala Asp Leu Ala Cys Lys Leu Leu Gln Asp Glu Ala 
                325                 330                 335     

Thr Tyr Arg Ala Phe Ser Ala Arg Ala Arg Glu Arg Ala Val Arg Ala 
            340                 345                 350         

Phe His Val Asp Glu Lys Val Ser Glu Tyr Glu Ala Leu Tyr Arg Glu 
        355                 360                 365             

Val Met Ala Ala Glu Arg Gly Glu His Ala His Pro Arg Pro Gly Ala 
    370                 375                 380                 

<210>   60
<211>   384
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 52

<400>   60
Met Arg Val Gly Ile Ser Cys Tyr Pro Thr Val Gly Gly Ser Gly Ala 
                5                   10                  15      

Val Ala Thr Glu Leu Gly Lys Ala Leu Ala Arg Arg Gly His Glu Val 
            20                  25                  30          

His Phe Ile Val Thr Asp Val Pro Phe Arg Leu Gly Ala Phe Val Glu 
        35                  40                  45              

His Val Tyr Ile His Gln Ile Glu Pro Ile Thr Tyr Pro Val Leu Lys 
    50                  55                  60                  

Thr Pro Pro Tyr Asp Phe Ala Leu Ala Ser Leu Met Ala Arg Val Ala 
65                  70                  75                  80  

Asp Glu Tyr Gln Leu Asp Val Leu His Ala His Tyr Ala Leu Pro Phe 
                85                  90                  95      

Ala Val Cys Ala His Leu Ala Arg Glu Met Ala Lys His Pro Ile Arg 
            100                 105                 110         

Val Val Thr Thr Leu His Gly Thr Asp Ile Thr Val Leu Ala Gln Asp 
        115                 120                 125             

Pro Ser Leu Lys Ser Ile Ile Lys Leu Gly Ile Glu Arg Ser Asp Ala 
    130                 135                 140                 

Val Thr Ala Val Ser Gln Ser Leu Val Arg Asp Thr Ala Arg Leu Phe 
145                 150                 155                 160 

Glu Thr Asp Lys Pro Ile Arg Cys Ile Tyr Asn Phe Val Asp Pro Asp 
                165                 170                 175     

Val Phe Arg Pro Gly Cys Gly Gly Glu Leu Lys Arg His Phe Ala Pro 
            180                 185                 190         

Asn Gly Glu Arg Val Leu Leu His Ile Ser Asn Phe Arg Pro Val Lys 
        195                 200                 205             

Arg Leu His Asp Val Ile Ala Val Phe Glu Arg Val Ala Arg Arg Met 
    210                 215                 220                 

Pro Ala Lys Leu Leu Leu Val Gly Glu Gly Pro Asp Leu Gly Ala Ala 
225                 230                 235                 240 

Lys Arg Gln Val Glu Glu Ala Gly Leu Gly Asp Arg Val His Phe Leu 
                245                 250                 255     

Gly Arg Gln Asp Glu Val Ala Pro Leu Phe Ala Ala Ala Asp Leu Phe 
            260                 265                 270         

Leu Leu Pro Ser Glu Ser Glu Ser Phe Gly Leu Val Ala Leu Glu Ala 
        275                 280                 285             

Met Ser Cys Gly Val Pro Val Val Gly Ser Thr Ala Gly Gly Ile Pro 
    290                 295                 300                 

Glu Val Val Val His Gly Glu Thr Gly Phe Leu Ala Pro Val Gly Arg 
305                 310                 315                 320 

Val Asp Asp Met Ala Asp Leu Ala Cys Lys Leu Leu Gln Asp Glu Ala 
                325                 330                 335     

Thr Tyr Arg Ala Phe Ser Ala Arg Ala Arg Glu Arg Ala Ile Arg Ala 
            340                 345                 350         

Phe His Val Asp Glu Lys Val Ser Glu Tyr Glu Ala Leu Tyr Arg Glu 
        355                 360                 365             

Val Met Ala Ala Glu Arg Gly Glu His Ala His Pro Arg Pro Gly Ala 
    370                 375                 380                 

<210>   61
<211>   384
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 52

<400>   61
Met Arg Val Gly Ile Ser Cys Tyr Pro Thr Val Gly Gly Ser Gly Ala 
                5                   10                  15      

Val Ala Thr Glu Leu Gly Lys Ala Leu Ala Arg Arg Gly His Glu Val 
            20                  25                  30          

His Phe Ile Val Thr Asp Val Pro Phe Arg Leu Gly Ala Phe Val Glu 
        35                  40                  45              

His Val Tyr Ile His Gln Ile Glu Pro Ile Thr Tyr Pro Val Leu Lys 
    50                  55                  60                  

Thr Pro Pro Tyr Asp Phe Ala Leu Ala Ser Leu Met Ala Arg Val Ala 
65                  70                  75                  80  

Asp Glu Tyr Gln Leu Asp Val Leu His Ala His Tyr Ala Leu Pro Phe 
                85                  90                  95      

Ala Val Cys Ala His Leu Ala Arg Glu Met Ala Lys His Pro Ile Arg 
            100                 105                 110         

Val Val Thr Thr Leu His Gly Thr Asp Ile Thr Val Leu Ala Gln Asp 
        115                 120                 125             

Pro Ser Leu Lys Ser Leu Ile Lys Leu Gly Ile Glu Arg Ser Asp Ala 
    130                 135                 140                 

Val Thr Ala Val Ser Gln Ser Leu Val Arg Asp Thr Ala Arg Leu Phe 
145                 150                 155                 160 

Glu Thr Asp Lys Pro Ile Arg Cys Ile Tyr Asn Phe Val Asp Pro Asp 
                165                 170                 175     

Val Phe Arg Pro Gly Cys Gly Gly Glu Leu Lys Arg His Phe Ala Pro 
            180                 185                 190         

Asn Gly Glu Arg Val Leu Leu His Ile Ser Asn Phe Arg Pro Val Lys 
        195                 200                 205             

Arg Leu His Asp Val Ile Ala Val Phe Glu Arg Val Ala Arg Arg Met 
    210                 215                 220                 

Pro Ala Lys Leu Leu Leu Val Gly Glu Gly Pro Asp Leu Gly Ala Ala 
225                 230                 235                 240 

Lys Arg Gln Val Glu Glu Ala Gly Leu Gly Asp Arg Val His Phe Leu 
                245                 250                 255     

Gly Arg Gln Asp Glu Val Ala Pro Leu Phe Ala Ala Ala Asp Leu Phe 
            260                 265                 270         

Leu Leu Pro Ser Glu Ser Glu Ser Phe Gly Leu Val Ala Leu Glu Ala 
        275                 280                 285             

Met Ser Cys Gly Val Pro Val Val Gly Ser Thr Ala Gly Gly Ile Pro 
    290                 295                 300                 

Glu Val Val Val His Gly Glu Thr Gly Phe Leu Ala Pro Val Gly Arg 
305                 310                 315                 320 

Val Asp Asp Met Ala Asp Leu Ala Cys Lys Leu Leu Gln Asp Glu Ala 
                325                 330                 335     

Thr Tyr Arg Ala Phe Ser Ala Arg Ala Arg Glu Arg Ala Val Arg Ala 
            340                 345                 350         

Phe His Val Asp Glu Lys Val Ser Glu Tyr Glu Ala Leu Tyr Arg Glu 
        355                 360                 365             

Val Met Ala Ala Glu Arg Gly Glu His Ala His Pro Arg Pro Gly Ala 
    370                 375                 380                 

<210>   62
<211>   384
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 52

<400>   62
Met Arg Val Gly Ile Ser Cys Tyr Pro Thr Val Gly Gly Ser Gly Ala 
                5                   10                  15      

Val Ala Thr Glu Leu Gly Lys Ala Leu Ala Arg Arg Gly His Glu Val 
            20                  25                  30          

His Phe Ile Val Thr Asp Val Pro Phe Arg Leu Gly Ala Phe Val Glu 
        35                  40                  45              

His Val Tyr Ile His Gln Ile Glu Pro Ile Thr Tyr Pro Val Leu Lys 
    50                  55                  60                  

Thr Pro Pro Tyr Asp Phe Ala Leu Ala Ser Leu Met Ala Arg Val Ala 
65                  70                  75                  80  

Asp Glu Tyr Gln Leu Asp Val Leu His Ala His Tyr Ala Leu Pro Phe 
                85                  90                  95      

Ala Val Cys Ala His Leu Ala Arg Glu Met Ala Lys His Pro Ile Arg 
            100                 105                 110         

Val Val Thr Thr Leu His Gly Thr Asp Ile Thr Val Leu Ala Gln Asp 
        115                 120                 125             

Pro Ser Leu Lys Ser Ile Ile Lys Leu Gly Ile Glu Arg Ser Asp Ala 
    130                 135                 140                 

Val Thr Ala Val Ser Gln Ser Leu Val Arg Asp Thr Ala Arg Leu Phe 
145                 150                 155                 160 

Glu Thr Asp Lys Pro Ile Arg Cys Ile Tyr Asn Phe Val Asp Pro Asp 
                165                 170                 175     

Val Phe Arg Pro Gly Cys Gly Gly Glu Leu Lys Arg His Phe Ala Pro 
            180                 185                 190         

Asn Gly Glu Arg Val Leu Leu His Ile Ser Asn Phe Arg Pro Val Lys 
        195                 200                 205             

Arg Leu His Asp Val Ile Ala Val Phe Glu Arg Val Ala Arg Arg Met 
    210                 215                 220                 

Pro Ala Lys Leu Leu Leu Val Gly Glu Gly Pro Asp Leu Gly Ala Ala 
225                 230                 235                 240 

Lys Arg Gln Val Glu Glu Ala Gly Leu Gly Asp Arg Val His Phe Leu 
                245                 250                 255     

Gly Arg Gln Asp Glu Val Ala Pro Leu Phe Ala Ala Ala Asp Leu Phe 
            260                 265                 270         

Leu Leu Pro Ser Glu Ser Glu Ser Phe Gly Leu Val Ala Leu Glu Ala 
        275                 280                 285             

Met Ser Cys Gly Val Pro Val Val Gly Ser Thr Ala Gly Gly Ile Pro 
    290                 295                 300                 

Glu Val Val Val His Gly Glu Thr Gly Phe Leu Ala Pro Val Gly Arg 
305                 310                 315                 320 

Val Asp Asp Met Ala Asp Leu Ala Cys Lys Leu Leu Gln Asp Asp Ala 
                325                 330                 335     

Thr Tyr Arg Ala Phe Ser Ala Arg Ala Arg Glu Arg Ala Val Arg Ala 
            340                 345                 350         

Phe His Val Asp Glu Lys Val Ser Glu Tyr Glu Ala Leu Tyr Arg Glu 
        355                 360                 365             

Val Met Ala Ala Glu Arg Gly Glu His Ala His Pro Arg Pro Gly Ala 
    370                 375                 380                 

<210>   63
<211>   384
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 52

<400>   63
Met Arg Val Gly Ile Ser Cys Tyr Pro Thr Val Gly Gly Ser Gly Ala 
                5                   10                  15      

Val Ala Thr Glu Leu Gly Lys Ala Leu Ala Arg Arg Gly His Glu Val 
            20                  25                  30          

His Phe Ile Val Thr Asp Val Pro Phe Arg Leu Gly Ala Phe Val Glu 
        35                  40                  45              

His Val Tyr Ile His Gln Ile Glu Pro Ile Thr Tyr Pro Val Leu Lys 
    50                  55                  60                  

Thr Pro Pro Tyr Asp Phe Ala Leu Ala Ser Leu Met Ala Arg Val Ala 
65                  70                  75                  80  

Asp Glu Tyr Gln Leu Asp Val Leu His Ala His Tyr Ala Leu Pro Phe 
                85                  90                  95      

Ala Val Cys Ala His Leu Ala Arg Glu Met Ala Lys His Pro Ile Arg 
            100                 105                 110         

Val Val Thr Thr Leu His Gly Thr Asp Ile Thr Val Leu Ala Gln Asp 
        115                 120                 125             

Pro Ser Leu Lys Ser Ile Ile Lys Leu Gly Ile Glu Arg Ser Asp Ala 
    130                 135                 140                 

Val Thr Ala Val Ser Gln Ser Leu Val Arg Asp Thr Ala Arg Ile Phe 
145                 150                 155                 160 

Glu Thr Asp Lys Pro Ile Arg Cys Ile Tyr Asn Phe Val Asp Pro Asp 
                165                 170                 175     

Val Phe Arg Pro Gly Cys Gly Gly Glu Leu Lys Arg His Phe Ala Pro 
            180                 185                 190         

Asn Gly Glu Arg Val Leu Leu His Ile Ser Asn Phe Arg Pro Val Lys 
        195                 200                 205             

Arg Leu His Asp Val Ile Ala Val Phe Glu Arg Val Ala Arg Arg Met 
    210                 215                 220                 

Pro Ala Lys Leu Leu Leu Val Gly Glu Gly Pro Asp Leu Gly Ala Ala 
225                 230                 235                 240 

Lys Arg Gln Val Glu Glu Ala Gly Leu Gly Asp Arg Val His Phe Leu 
                245                 250                 255     

Gly Arg Gln Asp Glu Val Ala Pro Leu Phe Ala Ala Ala Asp Leu Phe 
            260                 265                 270         

Leu Leu Pro Ser Glu Ser Glu Ser Phe Gly Leu Val Ala Leu Glu Ala 
        275                 280                 285             

Met Ser Cys Gly Val Pro Val Val Gly Ser Thr Ala Gly Gly Ile Pro 
    290                 295                 300                 

Glu Val Val Val His Gly Glu Thr Gly Phe Leu Ala Pro Val Gly Arg 
305                 310                 315                 320 

Val Asp Asp Met Ala Asp Leu Ala Cys Lys Leu Leu Gln Asp Glu Ala 
                325                 330                 335     

Thr Tyr Arg Ala Phe Ser Ala Arg Ala Arg Glu Arg Ala Val Arg Ala 
            340                 345                 350         

Phe His Val Asp Glu Lys Val Ser Glu Tyr Glu Ala Leu Tyr Arg Glu 
        355                 360                 365             

Val Met Ala Ala Glu Arg Gly Glu His Ala His Pro Arg Pro Gly Ala 
    370                 375                 380                 

<210>   64
<211>   1155
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 53

<400>   64
ttgcgcgtgg gtatcagctg ttatccgacg gtgggcggat ccggagcggt ggccaccgag       60

cttggcaagg cgctcgcgcg gcggggacac gaggtgcact tcatcgtgac cgacgtgccg      120

ttccggctcg gcgcgtttgt ggaacacgtg tacattcacc aaatcgagcc catcacgtac      180

ccggtcctca agaccccgcc gtacgacttt gcgctcgcca gtctcatggc gcgcgtggcc      240

gatgaatacc aactcgacgt gctgcacgcg cactacgccc ttccgtttgc ggtgtgtgca      300

cacctggcgc gcgagatggc gaagcatccc atccgggtgg tcaccacctt gcatggcacg      360

gacatcacgg tgttggccca ggatccgagc ctcaagtcca tcatcaaact cggcatcgag      420

cgcagcgacg cggtgacggc cgtcagccag agcctggtcc gggacacggc acgcttgttc      480

gagacggaca aaccgattcg ctgcatctac aacttcgtcg atcccgacgt gtttcggccc      540

gggtgcggcg gggatctgaa gcgccacttc gcgccaaacg gcgagcgcgt tctgcttcac      600

atctccaact tccgcccggt caaacggctt cacgacgtga tcgccgtgtt tgagcgcgtg      660

gcgagacgca tgccggcgaa gctgctcctc gtcggcgaag ggccggatct gggagcggcc      720

aaacgccagg tggaggaggc gggtctcggc gatcgcgtgc attttttggg gcgccaggac      780

gaggtggcgc cgctttttgc ggccgccgat ctgttcctgc tgccttccga aagcgagagc      840

ttcggcctcg tcgcgctcga ggcgatgtct tgcggcgtgc ccgttgtcgg atcgacggcc      900

ggcggcattc cggaggtggt tgtgcacggg gagaccggct ttctcgcgcc cgtcggccgc      960

gtcgacgaca tggcggatct cgcctgtaag cttttgcaag acgaggccac gtaccgggcg     1020

ttctccgcgc gagcccgcga gcgagccgtg cgagcgtttc atgtggatga gaaggtcagc     1080

gagtacgagg ctttgtatcg cgaggtgatg gcggctgaac gcggcgagca tgcgcatccc     1140

cgccccggcg cgtga                                                      1155


<210>   65
<211>   1155
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 53

<400>   65
ttgcgcgtgg gtatcagctg ttatccgacg gtgggcggat ccggagcggt ggccaccgag       60

cttggcaagg cgctcgcgcg gcggggacac gaggtgcact tcatcgtgac cgacgtgccg      120

ttccggctcg gcgcgtttgt ggaacacgtg tacattcacc aaatcgagcc catcacgtac      180

ccggtcctca agaccccgcc gtacgacttt gcgctcgcca gtctcatggc gcgcgtggcc      240

gatgaatacc aactcgacgt gctgcacgcg cactacgccc ttccgtttgc ggtgtgtgca      300

cacctggcgc gcgagatggc gaagcatccc atccgggtgg tcaccacctt gcatggcacg      360

gacatcacgg tgttggccca ggatccgagc ctcaagtcca tcatcaaact cggcatcgag      420

cgcagcgacg cggtgacggc cgtcagccag agcctggtcc gggacacggc acgcttgttc      480

gagacggaca aaccgattcg ctgcatctac aacttcgtcg atcccgacgt gtttcggccc      540

gggtgcggcg gggaactgaa gcgccacttc gcgccaaacg gcgagcgcgt tctgcttcac      600

atctccaact tccgcccggt caaacggctt cacgacgtga tcgccgtgtt tgagcgcgtg      660

gcgagacgca tgccggcgaa gctgctcctc gtcggcgaag ggccggatct gggagcggcc      720

aaacgccagg tggaggaggc gggtctcggc gatcgcgtgc attttttggg gcgccaggac      780

gaggtggcgc cgctttttgc ggccgccgat ctgttcctgc tgccttccga aagcgagagc      840

ttcggcctcg tcgcgctcga ggcgatgtct tgcggcgtgc ccgttgtcgg atcgacggcc      900

ggcggcattc cggaggtggt tgtgcacggg gagaccggct ttctcgcgcc cgtcggccgc      960

gtcgacgaca tggcggatct cgcctgtaag cttttgcaag acgaggccac gtaccgggcg     1020

ttctccgcgc gagcccgcga gcgagccatt cgagcgtttc atgtggatga gaaggtcagc     1080

gagtacgagg ctttgtatcg cgaggtgatg gcggctgaac gcggcgagca tgcgcatccc     1140

cgccccggcg cgtga                                                      1155


<210>   66
<211>   1155
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 53

<400>   66
ttgcgcgtgg gtatcagctg ttatccgacg gtgggcggat ccggagcggt ggccaccgag       60

cttggcaagg cgctcgcgcg gcggggacac gaggtgcact tcatcgtgac cgacgtgccg      120

ttccggctcg gcgcgtttgt ggaacacgtg tacattcacc aaatcgagcc catcacgtac      180

ccggtcctca agaccccgcc gtacgacttt gcgctcgcca gtctcatggc gcgcgtggcc      240

gatgaatacc aactcgacgt gctgcacgcg cactacgccc ttccgtttgc ggtgtgtgca      300

cacctggcgc gcgagatggc gaagcatccc atccgggtgg tcaccacctt gcatggcacg      360

gacatcacgg tgttggccca ggatccgagc ctcaagtcct taatcaaact cggcatcgag      420

cgcagcgacg cggtgacggc cgtcagccag agcctggtcc gggacacggc acgcttgttc      480

gagacggaca aaccgattcg ctgcatctac aacttcgtcg atcccgacgt gtttcggccc      540

gggtgcggcg gggaactgaa gcgccacttc gcgccaaacg gcgagcgcgt tctgcttcac      600

atctccaact tccgcccggt caaacggctt cacgacgtga tcgccgtgtt tgagcgcgtg      660

gcgagacgca tgccggcgaa gctgctcctc gtcggcgaag ggccggatct gggagcggcc      720

aaacgccagg tggaggaggc gggtctcggc gatcgcgtgc attttttggg gcgccaggac      780

gaggtggcgc cgctttttgc ggccgccgat ctgttcctgc tgccttccga aagcgagagc      840

ttcggcctcg tcgcgctcga ggcgatgtct tgcggcgtgc ccgttgtcgg atcgacggcc      900

ggcggcattc cggaggtggt tgtgcacggg gagaccggct ttctcgcgcc cgtcggccgc      960

gtcgacgaca tggcggatct cgcctgtaag cttttgcaag acgaggccac gtaccgggcg     1020

ttctccgcgc gagcccgcga gcgagccgtg cgagcgtttc atgtggatga gaaggtcagc     1080

gagtacgagg ctttgtatcg cgaggtgatg gcggctgaac gcggcgagca tgcgcatccc     1140

cgccccggcg cgtga                                                      1155


<210>   67
<211>   1155
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 53

<400>   67
ttgcgcgtgg gtatcagctg ttatccgacg gtgggcggat ccggagcggt ggccaccgag       60

cttggcaagg cgctcgcgcg gcggggacac gaggtgcact tcatcgtgac cgacgtgccg      120

ttccggctcg gcgcgtttgt ggaacacgtg tacattcacc aaatcgagcc catcacgtac      180

ccggtcctca agaccccgcc gtacgacttt gcgctcgcca gtctcatggc gcgcgtggcc      240

gatgaatacc aactcgacgt gctgcacgcg cactacgccc ttccgtttgc ggtgtgtgca      300

cacctggcgc gcgagatggc gaagcatccc atccgggtgg tcaccacctt gcatggcacg      360

gacatcacgg tgttggccca ggatccgagc ctcaagtcca tcatcaaact cggcatcgag      420

cgcagcgacg cggtgacggc cgtcagccag agcctggtcc gggacacggc acgcttgttc      480

gagacggaca aaccgattcg ctgcatctac aacttcgtcg atcccgacgt gtttcggccc      540

gggtgcggcg gggaactgaa gcgccacttc gcgccaaacg gcgagcgcgt tctgcttcac      600

atctccaact tccgcccggt caaacggctt cacgacgtga tcgccgtgtt tgagcgcgtg      660

gcgagacgca tgccggcgaa gctgctcctc gtcggcgaag ggccggatct gggagcggcc      720

aaacgccagg tggaggaggc gggtctcggc gatcgcgtgc attttttggg gcgccaggac      780

gaggtggcgc cgctttttgc ggccgccgat ctgttcctgc tgccttccga aagcgagagc      840

ttcggcctcg tcgcgctcga ggcgatgtct tgcggcgtgc ccgttgtcgg atcgacggcc      900

ggcggcattc cggaggtggt tgtgcacggg gagaccggct ttctcgcgcc cgtcggccgc      960

gtcgacgaca tggcggatct cgcctgtaag cttttgcaag acgatgccac gtaccgggcg     1020

ttctccgcgc gagcccgcga gcgagccgtg cgagcgtttc atgtggatga gaaggtcagc     1080

gagtacgagg ctttgtatcg cgaggtgatg gcggctgaac gcggcgagca tgcgcatccc     1140

cgccccggcg cgtga                                                      1155


<210>   68
<211>   1155
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 53

<400>   68
ttgcgcgtgg gtatcagctg ttatccgacg gtgggcggat ccggagcggt ggccaccgag       60

cttggcaagg cgctcgcgcg gcggggacac gaggtgcact tcatcgtgac cgacgtgccg      120

ttccggctcg gcgcgtttgt ggaacacgtg tacattcacc aaatcgagcc catcacgtac      180

ccggtcctca agaccccgcc gtacgacttt gcgctcgcca gtctcatggc gcgcgtggcc      240

gatgaatacc aactcgacgt gctgcacgcg cactacgccc ttccgtttgc ggtgtgtgca      300

cacctggcgc gcgagatggc gaagcatccc atccgggtgg tcaccacctt gcatggcacg      360

gacatcacgg tgttggccca ggatccgagc ctcaagtcca tcatcaaact cggcatcgag      420

cgcagcgacg cggtgacggc cgtcagccag agcctggtcc gggacacggc acgcattttc      480

gagacggaca aaccgattcg ctgcatctac aacttcgtcg atcccgacgt gtttcggccc      540

gggtgcggcg gggaactgaa gcgccacttc gcgccaaacg gcgagcgcgt tctgcttcac      600

atctccaact tccgcccggt caaacggctt cacgacgtga tcgccgtgtt tgagcgcgtg      660

gcgagacgca tgccggcgaa gctgctcctc gtcggcgaag ggccggatct gggagcggcc      720

aaacgccagg tggaggaggc gggtctcggc gatcgcgtgc attttttggg gcgccaggac      780

gaggtggcgc cgctttttgc ggccgccgat ctgttcctgc tgccttccga aagcgagagc      840

ttcggcctcg tcgcgctcga ggcgatgtct tgcggcgtgc ccgttgtcgg atcgacggcc      900

ggcggcattc cggaggtggt tgtgcacggg gagaccggct ttctcgcgcc cgtcggccgc      960

gtcgacgaca tggcggatct cgcctgtaag cttttgcaag acgaggccac gtaccgggcg     1020

ttctccgcgc gagcccgcga gcgagccgtg cgagcgtttc atgtggatga gaaggtcagc     1080

gagtacgagg ctttgtatcg cgaggtgatg gcggctgaac gcggcgagca tgcgcatccc     1140

cgccccggcg cgtga                                                      1155


<210>   69
<211>   398
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   69
Met Thr Ala Leu Ala Trp Ala Ala Ala Val Ser Leu Ala Ala Trp Ile 
                5                   10                  15      

Phe Leu Leu Phe Gly Arg Gly Phe Tyr Trp Arg Thr Ala Leu Ser Met 
            20                  25                  30          

Asn Thr Ala Arg Met Ala Ala Glu Ala Arg Ala Pro Arg Ala Trp Pro 
        35                  40                  45              

Ala Val Trp Ala Val Val Pro Ala Arg Asn Glu Ala Asp Val Leu Pro 
    50                  55                  60                  

Arg Thr Leu Pro Thr Leu Leu Ser Gln Ala Tyr Pro Gly Glu Phe His 
65                  70                  75                  80  

Val Val Leu Val Asp Asp His Ser Thr Asp Gly Thr Ala Glu Val Ala 
                85                  90                  95      

Glu Arg Leu Ala Ser Glu Leu Arg Leu Ala His Arg Leu Arg Val Val 
            100                 105                 110         

Arg Ala Asp Ala Leu Pro Pro Gly Trp Ala Gly Lys Val Trp Ala Met 
        115                 120                 125             

Gln Asn Gly Leu Arg His Val Pro Asp Asp Ala Ala Tyr Val Leu Phe 
    130                 135                 140                 

Thr Asp Ala Asp Ile Ser His Ser Pro Thr Ser Val Gln Ala Leu Val 
145                 150                 155                 160 

Ala Arg Ala Glu Arg Asp Gly Leu Asp Leu Val Ser Leu Met Val Arg 
                165                 170                 175     

Leu Arg Ala Glu Ser Ala Trp Glu Lys Leu Leu Ile Pro Ala Phe Val 
            180                 185                 190         

Tyr Phe Phe Ala Lys Leu Tyr Pro Phe Ala Trp Val Ala His Pro Arg 
        195                 200                 205             

Arg Arg Thr Ala Ala Ala Ala Gly Gly Cys Val Leu Val Arg Arg Arg 
    210                 215                 220                 

Leu Leu Pro Thr Pro Pro Gly Leu Glu Ala Ile Arg Asp Ala Val Ile 
225                 230                 235                 240 

Asp Asp Cys Ala Leu Ala Arg Leu Val Ala Asp Gly Gly Gly Arg Leu 
                245                 250                 255     

Trp Leu Gly Leu Gly Asp Asp Val Val Ser Val Arg Ala Tyr Gly Thr 
            260                 265                 270         

Leu Gly Glu Ile Trp Arg Met Ile Ala Arg Thr Ala Phe Val Gln Leu 
        275                 280                 285             

Arg Phe Ser Thr Val Leu Leu Leu Gly Thr Ala Leu Gly Met Leu Leu 
    290                 295                 300                 

Leu Tyr Ala Val Pro Pro Ala Ala Ala Ile Ala Gly Leu Val Gly Leu 
305                 310                 315                 320 

Leu Ala Gly Ala Pro Gly Ser Leu Ala Ala Leu Cys Leu Gly Gly Leu 
                325                 330                 335     

Ala Tyr Ala Ile Leu Ala Ser Thr Phe Val Pro Met Leu Arg Trp Tyr 
            340                 345                 350         

Arg Leu Ser Pro Ala Arg Ser Ala Leu Leu Pro Leu Ala Gly Val Leu 
        355                 360                 365             

Tyr Thr Leu Met Thr Leu Asp Ser Ala Arg Arg Phe Trp Leu Arg Thr 
    370                 375                 380                 

Gly Asp His Trp Lys Gly Arg Pro Tyr Glu Met Arg Arg Pro 
385                 390                 395             

<210>   70
<211>   1197
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   70
atgacggcgc tggcttgggc cgcggccgta agcctcgcgg cgtggatctt cctgcttttc       60

gggcgcggct tctattggcg cacggcgctc tccatgaaca ccgcaaggat ggcggccgag      120

gccagggcgc cccgcgcgtg gccggccgtg tgggccgtgg tgcccgcgcg caacgaggcg      180

gacgtcttgc cgaggacgct tccgacgctt ctctcgcagg cgtaccccgg tgagttccac      240

gtcgtgctcg tggacgatca cagcacagac ggcacggcgg aggtggccga gcgccttgcg      300

tcggagctta ggctcgcgca tcgtctgcgc gtggtgcgcg cggatgcgct tccgcctggg      360

tgggcgggca aggtgtgggc catgcagaat ggtctcaggc acgtgccgga cgatgcggcg      420

tacgtgctgt tcacggacgc ggacatctcg cattcaccga cgagcgtcca ggccctcgtg      480

gcgcgggccg agcgagacgg gttggacctc gtctcgctca tggttcggct cagggccgag      540

agcgcatggg aaaagctcct cattccagcg ttcgtctact tcttcgcgaa gctgtacccg      600

ttcgcgtggg tcgctcaccc taggcgaagg accgcggccg cggcgggcgg atgcgtgctc      660

gtcaggcgcc gcctgttgcc cacgcccccg gggcttgagg ccattcgcga cgccgtgatc      720

gacgactgtg cgctcgctcg gctcgtggcg gatggcggcg ggcgcctctg gctcgggctt      780

ggcgacgacg tggtgagcgt gcgggcgtac ggaaccctcg gcgaaatctg gcggatgatt      840

gcgcgcaccg cgttcgtgca gctgcggttc tccaccgtgc tcctcttggg caccgccctc      900

ggcatgctcc tcttgtacgc cgtgccaccc gctgccgcaa tcgccggcct cgtgggtctt      960

ctggcgggcg cgccggggag cctcgccgct ttgtgccttg gcgggctcgc gtacgccatc     1020

ctcgcctcga ccttcgtgcc gatgctccgg tggtaccgcc tgtctccggc gcgatccgcc     1080

ctgcttccct tggccggcgt cctgtacacc ctcatgaccc tcgactccgc caggcggttc     1140

tggctccgca cgggcgatca ctggaagggt cggccgtacg aaatgcgccg cccgtga        1197


<210>   71
<211>   341
<212>   PRT
<213>   Acaryochloris marina MBIC11017

<400>   71
Asn Glu Ala Glu Val Leu Pro Val Ser Leu Arg Ser Leu Leu Gln Gln 
                5                   10                  15      

Thr Tyr Pro Gly Pro Phe Lys Ile Leu Leu Ile Asp Asp Gln Ser Thr 
            20                  25                  30          

Asp Gln Thr Arg Glu Ile Ala Gln Gln Ile Ala Thr Asp Leu Asp Arg 
        35                  40                  45              

Asn His Gln Leu Gln Val Ile Gln Thr Ala Pro Leu Pro Pro Gly Trp 
    50                  55                  60                  

Ser Gly Lys Leu Trp Ala Met His Gln Gly Ile Glu Met Val Leu Ala 
65                  70                  75                  80  

Glu Ser Thr Gln Pro Thr Tyr Phe Leu Leu Thr Asp Ala Asp Ile Gln 
                85                  90                  95      

His Glu Ala Asn Ser Leu Leu Ser Leu Val Thr Lys Ala Glu Gln Glu 
            100                 105                 110         

Asp Gln Asp Met Val Ser Leu Met Val Arg Leu Arg Cys Gln Ser Ile 
        115                 120                 125             

Trp Glu Gln Leu Leu Ile Pro Ala Phe Val Phe Phe Phe Gln Lys Leu 
    130                 135                 140                 

Tyr Pro Phe Leu Trp Val Asn Gln Pro Gln Lys Gln Met Ala Ala Ala 
145                 150                 155                 160 

Ala Gly Gly Cys Ile Leu Val Arg Arg Gln Thr Leu Ser Thr Ile Gly 
                165                 170                 175     

Gly Ile Gln Val Ile Arg Asp Ala Leu Ile Asp Asp Cys Ala Leu Ala 
            180                 185                 190         

Ala Ala Ile Lys Gln Thr Pro Asn Ala Gln Pro Asn Arg Asn Ile Trp 
        195                 200                 205             

Leu Gly Leu Thr Ser Ala Thr Gln Ser Leu Arg Ser Tyr Asp Thr Leu 
    210                 215                 220                 

Asp Ser Ile Trp Ser Met Val Ala Arg Thr Ala Phe Thr Gln Leu Asn 
225                 230                 235                 240 

Tyr Ser Thr Leu Leu Leu Ile Gly Thr Val Val Gly Met Phe Leu Ile 
                245                 250                 255     

Tyr Met Val Pro Pro Ile Ser Ile Met Leu Gly Leu Tyr Leu Glu Ser 
            260                 265                 270         

Ile Ser Ile Thr Val Thr Gly Leu Ile Thr Trp Val Leu Met Thr Leu 
        275                 280                 285             

Ala Tyr Leu Pro Thr Ile Arg Leu Tyr Gln Leu Ser Pro Ile Trp Ala 
    290                 295                 300                 

Val Ser Leu Pro Leu Ile Ala Leu Leu Tyr Asn Leu Met Thr Leu Asp 
305                 310                 315                 320 

Ser Ala Arg Gln His Trp Gln Gly Lys Gly Gly Ala Trp Lys Gly Arg 
                325                 330                 335     

Val Tyr Pro Ala Arg 
            340     

<210>   72
<211>   370
<212>   PRT
<213>   Frankia alni ACN14a

<400>   72
Leu Tyr Leu Ala Val Gly His Gly Phe Phe Trp Arg Thr Asp Gln Arg 
                5                   10                  15      

Leu Pro Ala Arg Gln Ala Pro Pro Ser Trp Pro Ser Val Ala Ile Ile 
            20                  25                  30          

Ile Pro Ala Arg Asp Glu Ala Asp Val Leu Pro Val Thr Leu Pro Thr 
        35                  40                  45              

Leu Leu Ala Gln Asp Tyr Pro Gly Pro Val Arg Leu Ile Leu Val Asp 
    50                  55                  60                  

Asp Gly Ser Thr Asp Gly Thr Thr Glu Val Ala Arg Ala Leu Ala Glu 
65                  70                  75                  80  

Gln Ala Ala Arg Asn Gly His Thr Gly Val Thr Ala Ala Val Thr Ala 
                85                  90                  95      

Ser Thr Glu Pro Pro Pro Gly Trp Thr Gly Lys Leu Trp Ala Leu Arg 
            100                 105                 110         

Arg Gly Val Asp Cys Ala Gly Asp Ala Glu Phe Leu Leu Leu Thr Asp 
        115                 120                 125             

Ala Asp Ile Ala His Asp Pro Gly Ser Leu Thr Ser Leu Val Ala Ser 
    130                 135                 140                 

Ala Arg Thr His Gly Leu Asp Met Val Ser Gln Met Ala Val Leu Arg 
145                 150                 155                 160 

Ala Glu Thr Val Trp Glu Arg Val Ile Val Pro Ala Phe Val Tyr Phe 
                165                 170                 175     

Phe Ala Met Leu Tyr Pro Phe Arg Trp Ser Asn Arg Pro Arg Ser Arg 
            180                 185                 190         

Val Ala Ala Ala Ala Gly Gly Cys Ser Leu Val Arg Arg Glu Ala Leu 
        195                 200                 205             

Leu Ala Ala Gly Gly Leu Ala Glu Val Arg Gly Ala Val Ile Asp Asp 
    210                 215                 220                 

Val Ala Ile Ala Arg Ile Ile Lys Arg Ser Gly Gly Arg Thr Trp Leu 
225                 230                 235                 240 

Gly Leu Ala Glu Gln Val His Ser Arg Arg Pro Tyr Pro Arg Leu Ala 
                245                 250                 255     

Asp Leu Trp Lys Met Val Ser Arg Ser Ala Tyr Ala Gln Leu Arg His 
            260                 265                 270         

Ser Pro Leu Leu Leu Leu Gly Thr Val Leu Gly Met Ser Leu Val Phe 
        275                 280                 285             

Val Val Pro Val Val Ala Thr Ile Ala Gly Leu Ala Ala Gly Asp Gly 
    290                 295                 300                 

Thr Thr Ala Ile Leu Gly Ala Val Ala Trp Val Ile Met Thr Leu Ser 
305                 310                 315                 320 

Tyr Val Pro Met Ile Arg Tyr Tyr Arg Gln Pro Val Pro Ala Ala Leu 
                325                 330                 335     

Leu Leu Pro Gly Val Ala Val Leu Tyr Leu Gly Met Thr Leu Asp Ser 
            340                 345                 350         

Ala Arg Leu Lys Trp Ala Gly Arg Gly Ala Ala Trp Lys Gly Arg Thr 
        355                 360                 365             

Tyr Asp 
    370 

<210>   73
<211>   371
<212>   PRT
<213>   Burkholderia pseudomallei 406e

<400>   73
Leu Val Leu Leu Phe Gly Arg Gly Gly Phe Trp Arg Ala Arg Ala Ala 
                5                   10                  15      

Arg Arg Leu Pro Pro Asp Ala Arg Gly Ala Ala Ala Ala Ala Gly Trp 
            20                  25                  30          

Pro Ala Val Ala Ala Val Val Pro Ala Arg Asn Glu Ala Asp Val Ile 
        35                  40                  45              

Gly Glu Ala Val Arg Ser Leu Val Glu Gln Ala Tyr Glu Gly Ala Phe 
    50                  55                  60                  

His Leu Ile Val Val Asp Asp His Ser Thr Asp Gly Thr Ala Glu Ala 
65                  70                  75                  80  

Ala Arg Ala Ala Ala Ala Ala Val Gly Cys Ala Asp Arg Leu Thr Val 
                85                  90                  95      

Leu Ala Ala Gln Pro Leu Pro Ala Gly Trp Ser Gly Lys Val Trp Ala 
            100                 105                 110         

Gln Ser Gln Gly Ile Ala Ala Val Arg Ser Leu Gly Leu Pro Ala Asp 
        115                 120                 125             

Tyr Leu Leu Leu Thr Asp Ala Asp Ile Gly His Pro Pro Asp Ala Val 
    130                 135                 140                 

Ala Gln Leu Val Thr Arg Ala Gln Ala Glu Gln Arg Asp Leu Val Ser 
145                 150                 155                 160 

Leu Met Val Arg Leu Arg Cys Asp Ser Phe Trp Glu Lys Ala Leu Ile 
                165                 170                 175     

Pro Ala Phe Val Phe Phe Phe Ala Lys Leu Tyr Pro Phe Ser Trp Ile 
            180                 185                 190         

Asn Asp Pro Arg Asn Arg Thr Ala Gly Ala Ala Gly Gly Cys Met Leu 
        195                 200                 205             

Val Arg Arg Asp Ala Leu Glu Glu Ala Gly Gly Ile Glu Ser Ile Arg 
    210                 215                 220                 

Gly Ala Leu Ile Asp Asp Cys Ser Leu Ala Ala Gln Ile Lys His Arg 
225                 230                 235                 240 

Gly Ala Gly Arg His Pro Ile Arg Leu Asp Leu Ala Asp Arg Ser Val 
                245                 250                 255     

Ser Leu Arg Pro Tyr Asp Ser Trp Arg Asp Ile Trp Asn Met Ile Ala 
            260                 265                 270         

Arg Thr Ala Phe Thr Gln Leu Arg Tyr Ser Pro Val Leu Leu Leu Gly 
        275                 280                 285             

Thr Leu Val Gly Met Thr Ile Leu Tyr Leu Val Pro Pro Val Ala Ala 
    290                 295                 300                 

Leu Ala Tyr Gly Ala Arg Ala Trp Pro Ala Trp Leu Ala Trp Ala Ser 
305                 310                 315                 320 

Met Cys Thr Ala Tyr Ala Pro Met Leu Ser Tyr Tyr Arg Arg Ser Pro 
                325                 330                 335     

Trp Trp Ala Pro Ala Leu Pro Leu Val Ala Leu Phe Tyr Val Gly Ala 
            340                 345                 350         

Thr Phe Ala Ser Ala Val Arg Tyr Trp Arg Gly Lys Gly Gly Gln Trp 
        355                 360                 365             

Lys Ala Arg 
    370     

<210>   74
<211>   371
<212>   PRT
<213>   Burkholderia pseudomallei 1106a

<400>   74
Leu Val Leu Leu Phe Gly Arg Gly Gly Phe Trp Arg Ala Arg Ala Ala 
                5                   10                  15      

Arg Arg Leu Pro Pro Asp Ala Arg Gly Ala Ala Ala Ala Ala Gly Trp 
            20                  25                  30          

Pro Ala Val Ala Thr Val Val Pro Ala Arg Asn Glu Ala Asp Val Ile 
        35                  40                  45              

Gly Glu Ala Val Arg Ser Leu Val Glu Gln Ala Tyr Glu Gly Ala Phe 
    50                  55                  60                  

His Leu Ile Val Val Asp Asp His Ser Thr Asp Gly Thr Ala Glu Ala 
65                  70                  75                  80  

Ala Arg Ala Ala Ala Ala Ala Val Gly Cys Ala Asp Arg Leu Thr Val 
                85                  90                  95      

Leu Ala Ala Gln Pro Leu Pro Ala Gly Trp Ser Gly Lys Val Trp Ala 
            100                 105                 110         

Gln Ser Gln Gly Ile Ala Ala Val Arg Ser Leu Gly Leu Pro Ala Asp 
        115                 120                 125             

Tyr Leu Leu Leu Thr Asp Ala Asp Ile Gly His Pro Pro Asp Ala Val 
    130                 135                 140                 

Ala Gln Leu Val Thr Arg Ala Gln Ala Glu Gln Arg Asp Leu Val Ser 
145                 150                 155                 160 

Leu Met Val Arg Leu Arg Cys Asp Ser Phe Trp Glu Lys Ala Leu Ile 
                165                 170                 175     

Pro Ala Phe Val Phe Phe Phe Ala Lys Leu Tyr Pro Phe Ser Trp Ile 
            180                 185                 190         

Asn Asp Pro Arg Asn Arg Thr Ala Gly Ala Ala Gly Gly Cys Met Leu 
        195                 200                 205             

Val Arg Arg Asp Ala Leu Glu Glu Ala Gly Gly Ile Glu Ser Ile Arg 
    210                 215                 220                 

Gly Ala Leu Ile Asp Asp Cys Ser Leu Ala Ala Gln Ile Lys His Arg 
225                 230                 235                 240 

Gly Ala Gly Arg His Pro Ile Arg Leu Asp Leu Ala Asp Arg Ser Val 
                245                 250                 255     

Ser Leu Arg Pro Tyr Asp Ser Trp Arg Asp Ile Trp Asn Met Ile Ala 
            260                 265                 270         

Arg Thr Ala Phe Thr Gln Leu Arg Tyr Ser Pro Val Leu Leu Leu Gly 
        275                 280                 285             

Thr Leu Val Gly Met Thr Ile Leu Tyr Leu Val Pro Pro Val Ala Ala 
    290                 295                 300                 

Leu Ala Tyr Gly Ala Arg Ala Trp Pro Ala Trp Leu Ala Trp Ala Ser 
305                 310                 315                 320 

Met Cys Thr Ala Tyr Ala Pro Met Leu Ser Tyr Tyr Arg Arg Ser Pro 
                325                 330                 335     

Trp Trp Ala Pro Ala Leu Pro Leu Val Ala Leu Phe Tyr Val Gly Ala 
            340                 345                 350         

Thr Phe Ala Ser Ala Val Arg Tyr Trp Arg Gly Lys Gly Gly Gln Trp 
        355                 360                 365             

Lys Ala Arg 
    370     

<210>   75
<211>   371
<212>   PRT
<213>   Burkholderia pseudomallei 1710b

<400>   75
Leu Val Leu Leu Phe Gly Arg Gly Gly Phe Trp Arg Ala Arg Ala Ala 
                5                   10                  15      

Arg Arg Leu Pro Pro Asp Ala Arg Gly Ala Ala Ala Ala Ala Gly Trp 
            20                  25                  30          

Pro Ala Val Ala Ala Val Val Pro Ala Arg Asn Glu Ala Asp Val Ile 
        35                  40                  45              

Gly Glu Ala Val Arg Ser Leu Val Glu Gln Ala Tyr Glu Gly Ala Phe 
    50                  55                  60                  

His Leu Ile Val Val Asp Asp His Ser Thr Asp Gly Thr Ala Glu Ala 
65                  70                  75                  80  

Ala Arg Ala Ala Ala Ala Ala Val Gly Cys Ala Asp Arg Leu Thr Val 
                85                  90                  95      

Leu Ala Ala Gln Pro Leu Pro Ala Gly Trp Ser Gly Lys Val Trp Ala 
            100                 105                 110         

Gln Ser Gln Gly Ile Ala Ala Val Arg Ser Leu Gly Leu Pro Ala Asp 
        115                 120                 125             

Tyr Leu Leu Leu Thr Asp Ala Asp Ile Gly His Pro Pro Asp Ala Val 
    130                 135                 140                 

Ala Gln Leu Val Thr Arg Ala Gln Ala Glu Gln Arg Asp Leu Val Ser 
145                 150                 155                 160 

Leu Met Val Arg Leu Arg Cys Asp Ser Phe Trp Glu Lys Ala Leu Ile 
                165                 170                 175     

Pro Ala Phe Val Phe Phe Phe Ala Lys Leu Tyr Pro Phe Ser Trp Ile 
            180                 185                 190         

Asn Asp Pro Arg Asn Arg Thr Ala Gly Ala Ala Gly Gly Cys Met Leu 
        195                 200                 205             

Val Arg Arg Asp Ala Leu Glu Glu Ala Gly Gly Ile Glu Ser Ile Arg 
    210                 215                 220                 

Gly Ala Leu Ile Asp Asp Cys Ser Leu Ala Ala Gln Ile Lys His Arg 
225                 230                 235                 240 

Gly Ala Gly Arg His Pro Ile Arg Leu Asp Leu Ala Asp Arg Ser Val 
                245                 250                 255     

Ser Leu Arg Pro Tyr Asp Ser Trp Arg Asp Ile Trp Asn Met Ile Ala 
            260                 265                 270         

Arg Thr Ala Phe Thr Gln Leu Arg Tyr Ser Pro Val Leu Leu Leu Gly 
        275                 280                 285             

Thr Leu Val Gly Met Thr Ile Leu Tyr Leu Val Pro Pro Val Ala Ala 
    290                 295                 300                 

Leu Ala Tyr Gly Ala Arg Ala Trp Pro Ala Trp Leu Ala Trp Ala Ser 
305                 310                 315                 320 

Met Cys Thr Ala Tyr Ala Pro Met Leu Ser Tyr Tyr Arg Arg Ser Pro 
                325                 330                 335     

Trp Trp Ala Pro Ala Leu Pro Leu Val Ala Leu Phe Tyr Val Gly Ala 
            340                 345                 350         

Thr Phe Ala Ser Ala Val Arg Tyr Trp Arg Gly Lys Gly Gly Gln Trp 
        355                 360                 365             

Lys Ala Arg 
    370     

<210>   76
<211>   398
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 69

<400>   76
Met Thr Ala Leu Ala Trp Ala Ala Ala Val Ser Leu Ala Ala Trp Ile 
                5                   10                  15      

Phe Leu Leu Phe Gly Arg Gly Phe Tyr Trp Arg Thr Ala Leu Ser Met 
            20                  25                  30          

Asn Thr Ala Arg Met Ala Ala Glu Ala Arg Ala Pro Arg Ala Trp Pro 
        35                  40                  45              

Ala Val Trp Ala Val Val Pro Ala Arg Asn Glu Ala Asp Val Leu Pro 
    50                  55                  60                  

Arg Thr Leu Pro Thr Leu Leu Ser Gln Ala Tyr Pro Gly Glu Phe His 
65                  70                  75                  80  

Val Val Leu Val Asp Asp His Ser Thr Asp Gly Thr Ala Glu Val Ala 
                85                  90                  95      

Glu Arg Leu Ala Ser Glu Leu Arg Leu Ala His Arg Leu Arg Val Val 
            100                 105                 110         

Arg Ala Asp Ala Leu Pro Pro Gly Trp Ala Gly Lys Val Trp Ala Met 
        115                 120                 125             

Gln Asn Gly Leu Arg His Val Pro Asp Asp Ala Ala Tyr Val Leu Phe 
    130                 135                 140                 

Thr Asp Ala Asp Ile Ser His Ser Pro Thr Ser Val Gln Ala Leu Val 
145                 150                 155                 160 

Ala Arg Ala Glu Arg Asp Gly Leu Asp Leu Val Ser Leu Met Val Arg 
                165                 170                 175     

Leu Arg Ala Glu Ser Ala Trp Glu Lys Leu Leu Ile Pro Ala Phe Val 
            180                 185                 190         

Tyr Phe Phe Ala Lys Leu Tyr Pro Phe Ala Trp Val Ala His Pro Arg 
        195                 200                 205             

Lys Arg Thr Ala Ala Ala Ala Gly Gly Cys Val Leu Val Arg Arg Arg 
    210                 215                 220                 

Leu Leu Pro Thr Pro Pro Gly Leu Glu Ala Ile Arg Asp Ala Val Ile 
225                 230                 235                 240 

Asp Asp Cys Ala Leu Ala Arg Leu Val Ala Asp Gly Gly Gly Arg Leu 
                245                 250                 255     

Trp Leu Gly Leu Gly Asp Asp Val Val Ser Val Arg Ala Tyr Gly Thr 
            260                 265                 270         

Leu Gly Glu Ile Trp Arg Met Ile Ala Arg Thr Ala Phe Val Gln Leu 
        275                 280                 285             

Arg Phe Ser Thr Val Leu Leu Leu Gly Thr Ala Leu Gly Met Leu Leu 
    290                 295                 300                 

Leu Tyr Ala Val Pro Pro Ala Ala Ala Ile Ala Gly Leu Val Gly Leu 
305                 310                 315                 320 

Leu Ala Gly Ala Pro Gly Ser Leu Ala Ala Leu Cys Leu Gly Gly Leu 
                325                 330                 335     

Ala Tyr Ala Ile Leu Ala Ser Thr Phe Val Pro Met Leu Arg Trp Tyr 
            340                 345                 350         

Arg Leu Ser Pro Ala Arg Ser Ala Leu Leu Pro Leu Ala Gly Val Leu 
        355                 360                 365             

Tyr Thr Leu Met Thr Leu Asp Ser Ala Arg Arg Phe Trp Leu Arg Thr 
    370                 375                 380                 

Gly Asp His Trp Lys Gly Arg Pro Tyr Glu Met Arg Arg Pro 
385                 390                 395             

<210>   77
<211>   398
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 69

<400>   77
Met Thr Ala Leu Ala Trp Ala Ala Ala Val Ser Leu Ala Ala Trp Ile 
                5                   10                  15      

Phe Leu Leu Phe Gly Arg Gly Phe Tyr Trp Arg Thr Ala Leu Ser Met 
            20                  25                  30          

Asn Thr Ala Arg Met Ala Ala Glu Ala Arg Ala Pro Arg Ala Trp Pro 
        35                  40                  45              

Ala Val Trp Ala Val Val Pro Ala Arg Asn Glu Ala Asp Val Leu Pro 
    50                  55                  60                  

Arg Thr Leu Pro Thr Leu Leu Ser Gln Ala Tyr Pro Gly Glu Phe His 
65                  70                  75                  80  

Val Val Leu Val Asp Asp His Ser Thr Asp Gly Thr Ala Glu Val Ala 
                85                  90                  95      

Glu Arg Leu Ala Ser Glu Leu Arg Leu Ala His Arg Leu Arg Val Val 
            100                 105                 110         

Arg Ala Asp Ala Leu Pro Pro Gly Trp Ala Gly Lys Val Trp Ala Met 
        115                 120                 125             

Gln Asn Gly Leu Arg His Val Pro Asp Asp Ala Ala Tyr Val Leu Phe 
    130                 135                 140                 

Thr Asp Ala Asp Ile Ser His Ser Pro Thr Ser Val Gln Ala Leu Val 
145                 150                 155                 160 

Ala Arg Ala Glu Arg Asp Gly Leu Asp Leu Val Ser Leu Met Val Arg 
                165                 170                 175     

Leu Arg Ala Glu Ser Ala Trp Glu Lys Leu Leu Ile Pro Ala Phe Val 
            180                 185                 190         

Tyr Phe Phe Ala Lys Leu Tyr Pro Phe Ala Trp Val Ala His Pro Arg 
        195                 200                 205             

Arg Arg Thr Ala Ala Ala Ala Gly Gly Cys Val Leu Val Arg Arg Arg 
    210                 215                 220                 

Leu Leu Pro Thr Pro Pro Gly Leu Glu Ala Ile Arg Asp Ala Val Ile 
225                 230                 235                 240 

Asp Asp Cys Ala Leu Ala Arg Leu Val Ala Asp Gly Gly Gly Arg Leu 
                245                 250                 255     

Trp Leu Gly Leu Gly Asp Asp Val Val Ser Val Arg Ala Tyr Gly Thr 
            260                 265                 270         

Leu Gly Glu Ile Trp Arg Met Ile Ala Arg Thr Ala Phe Val Gln Leu 
        275                 280                 285             

Arg Phe Ser Thr Val Leu Leu Leu Gly Thr Ala Leu Gly Met Leu Leu 
    290                 295                 300                 

Leu Tyr Ala Val Pro Pro Ala Ala Ala Ile Ala Gly Leu Val Gly Leu 
305                 310                 315                 320 

Leu Ala Gly Ala Pro Gly Ser Leu Ala Ala Leu Cys Leu Gly Gly Leu 
                325                 330                 335     

Ala Tyr Ala Ile Leu Ala Ser Thr Phe Val Pro Met Leu Arg Trp Tyr 
            340                 345                 350         

Arg Leu Ser Pro Ala Arg Ser Ala Leu Leu Pro Leu Ala Gly Val Leu 
        355                 360                 365             

Tyr Thr Leu Met Thr Leu Asp Ser Ala Arg Arg Phe Trp Leu Arg Thr 
    370                 375                 380                 

Gly Asp His Trp Lys Gly Arg Pro Tyr Asp Met Arg Arg Pro 
385                 390                 395             

<210>   78
<211>   398
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 69

<400>   78
Met Thr Ala Leu Ala Trp Ala Ala Ala Val Ser Leu Ala Ala Trp Ile 
                5                   10                  15      

Phe Leu Leu Phe Gly Arg Gly Phe Tyr Trp Arg Thr Ala Leu Ser Met 
            20                  25                  30          

Asn Thr Ala Arg Met Ala Ala Glu Ala Arg Ala Pro Arg Ala Trp Pro 
        35                  40                  45              

Ala Val Trp Ala Val Val Pro Ala Arg Asn Glu Ala Asp Val Leu Pro 
    50                  55                  60                  

Arg Thr Leu Pro Thr Leu Leu Ser Gln Ala Tyr Pro Gly Glu Phe His 
65                  70                  75                  80  

Val Val Leu Val Asp Asp His Ser Thr Asp Gly Thr Ala Glu Val Ala 
                85                  90                  95      

Glu Arg Leu Ala Ser Glu Leu Arg Leu Ala His Arg Leu Arg Val Val 
            100                 105                 110         

Arg Ala Asp Ala Leu Pro Pro Gly Trp Ala Gly Lys Val Trp Ala Met 
        115                 120                 125             

Gln Asn Gly Leu Arg His Val Pro Asp Asp Ala Ala Tyr Val Leu Phe 
    130                 135                 140                 

Thr Asp Ala Asp Ile Ser His Ser Pro Thr Ser Val Gln Ala Leu Val 
145                 150                 155                 160 

Ala Arg Ala Glu Arg Asp Gly Leu Asp Leu Val Ser Leu Met Val Arg 
                165                 170                 175     

Leu Arg Ala Glu Ser Ala Trp Glu Lys Leu Leu Ile Pro Ala Phe Val 
            180                 185                 190         

Tyr Phe Phe Ala Lys Leu Tyr Pro Phe Ala Trp Val Ala His Pro Arg 
        195                 200                 205             

Arg Arg Thr Ala Ala Ala Ala Gly Gly Cys Val Leu Val Arg Arg Arg 
    210                 215                 220                 

Leu Leu Pro Thr Pro Pro Gly Leu Glu Ala Ile Arg Asp Ala Val Ile 
225                 230                 235                 240 

Asp Asp Cys Ala Leu Ala Arg Leu Val Ala Asp Gly Gly Gly Arg Ile 
                245                 250                 255     

Trp Leu Gly Leu Gly Asp Asp Val Val Ser Val Arg Ala Tyr Gly Thr 
            260                 265                 270         

Leu Gly Glu Ile Trp Arg Met Ile Ala Arg Thr Ala Phe Val Gln Leu 
        275                 280                 285             

Arg Phe Ser Thr Val Leu Leu Leu Gly Thr Ala Leu Gly Met Leu Leu 
    290                 295                 300                 

Leu Tyr Ala Val Pro Pro Ala Ala Ala Ile Ala Gly Leu Val Gly Leu 
305                 310                 315                 320 

Leu Ala Gly Ala Pro Gly Ser Leu Ala Ala Leu Cys Leu Gly Gly Leu 
                325                 330                 335     

Ala Tyr Ala Ile Leu Ala Ser Thr Phe Val Pro Met Leu Arg Trp Tyr 
            340                 345                 350         

Arg Leu Ser Pro Ala Arg Ser Ala Leu Leu Pro Leu Ala Gly Val Leu 
        355                 360                 365             

Tyr Thr Leu Met Thr Leu Asp Ser Ala Arg Arg Phe Trp Leu Arg Thr 
    370                 375                 380                 

Gly Asp His Trp Lys Gly Arg Pro Tyr Glu Met Arg Arg Pro 
385                 390                 395             

<210>   79
<211>   398
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 69

<400>   79
Met Thr Ala Leu Ala Trp Ala Ala Ala Val Ser Leu Ala Ala Trp Ile 
                5                   10                  15      

Phe Leu Leu Phe Gly Arg Gly Phe Tyr Trp Arg Thr Ala Leu Ser Met 
            20                  25                  30          

Asn Thr Ala Arg Met Ala Ala Glu Ala Arg Ala Pro Arg Ala Trp Pro 
        35                  40                  45              

Ala Val Trp Ala Val Val Pro Ala Arg Asn Glu Ala Asp Val Leu Pro 
    50                  55                  60                  

Arg Thr Leu Pro Thr Leu Leu Ser Gln Ala Tyr Pro Gly Glu Phe His 
65                  70                  75                  80  

Val Val Leu Val Asp Asp His Ser Thr Asp Gly Thr Ala Glu Val Ala 
                85                  90                  95      

Glu Arg Leu Ala Ser Glu Leu Arg Leu Ala His Arg Leu Arg Val Val 
            100                 105                 110         

Arg Ala Asp Ala Leu Pro Pro Gly Trp Ala Gly Lys Val Trp Ala Met 
        115                 120                 125             

Gln Asn Gly Leu Arg His Val Pro Asp Glu Ala Ala Tyr Val Leu Phe 
    130                 135                 140                 

Thr Asp Ala Asp Ile Ser His Ser Pro Thr Ser Val Gln Ala Leu Val 
145                 150                 155                 160 

Ala Arg Ala Glu Arg Asp Gly Leu Asp Leu Val Ser Leu Met Val Arg 
                165                 170                 175     

Leu Arg Ala Glu Ser Ala Trp Glu Lys Leu Leu Ile Pro Ala Phe Val 
            180                 185                 190         

Tyr Phe Phe Ala Lys Leu Tyr Pro Phe Ala Trp Val Ala His Pro Arg 
        195                 200                 205             

Arg Arg Thr Ala Ala Ala Ala Gly Gly Cys Val Leu Val Arg Arg Arg 
    210                 215                 220                 

Leu Leu Pro Thr Pro Pro Gly Leu Glu Ala Ile Arg Asp Ala Val Ile 
225                 230                 235                 240 

Asp Asp Cys Ala Leu Ala Arg Leu Val Ala Asp Gly Gly Gly Arg Leu 
                245                 250                 255     

Trp Leu Gly Leu Gly Asp Asp Val Val Ser Val Arg Ala Tyr Gly Thr 
            260                 265                 270         

Leu Gly Glu Ile Trp Arg Met Ile Ala Arg Thr Ala Phe Val Gln Leu 
        275                 280                 285             

Arg Phe Ser Thr Val Leu Leu Leu Gly Thr Ala Leu Gly Met Leu Leu 
    290                 295                 300                 

Leu Tyr Ala Val Pro Pro Ala Ala Ala Ile Ala Gly Leu Val Gly Leu 
305                 310                 315                 320 

Leu Ala Gly Ala Pro Gly Ser Leu Ala Ala Leu Cys Leu Gly Gly Leu 
                325                 330                 335     

Ala Tyr Ala Ile Leu Ala Ser Thr Phe Val Pro Met Leu Arg Trp Tyr 
            340                 345                 350         

Arg Leu Ser Pro Ala Arg Ser Ala Leu Leu Pro Leu Ala Gly Val Leu 
        355                 360                 365             

Tyr Thr Leu Met Thr Leu Asp Ser Ala Arg Arg Phe Trp Leu Arg Thr 
    370                 375                 380                 

Gly Asp His Trp Lys Gly Arg Pro Tyr Glu Met Arg Arg Pro 
385                 390                 395             

<210>   80
<211>   398
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 69

<400>   80
Met Thr Ala Leu Ala Trp Ala Ala Ala Val Ser Leu Ala Ala Trp Ile 
                5                   10                  15      

Phe Leu Leu Phe Gly Arg Gly Phe Tyr Trp Arg Thr Ala Leu Ser Met 
            20                  25                  30          

Asn Thr Ala Arg Met Ala Ala Glu Ala Arg Ala Pro Arg Ala Trp Pro 
        35                  40                  45              

Ala Val Trp Ala Val Val Pro Ala Arg Asn Glu Ala Asp Val Leu Pro 
    50                  55                  60                  

Arg Thr Leu Pro Thr Leu Leu Ser Gln Ala Tyr Pro Gly Glu Phe His 
65                  70                  75                  80  

Val Val Leu Val Asp Asp His Ser Thr Asp Gly Thr Ala Glu Val Ala 
                85                  90                  95      

Glu Arg Leu Ala Ser Glu Leu Arg Leu Ala His Arg Leu Arg Val Val 
            100                 105                 110         

Arg Ala Asp Ala Leu Pro Pro Gly Trp Ala Gly Lys Val Trp Ala Met 
        115                 120                 125             

Gln Asn Gly Leu Arg His Val Pro Asp Asp Ala Ala Tyr Val Leu Phe 
    130                 135                 140                 

Thr Asp Ala Asp Ile Ser His Ser Pro Thr Ser Val Gln Ala Leu Val 
145                 150                 155                 160 

Ala Arg Ala Glu Arg Asp Gly Leu Asp Leu Val Ser Leu Met Val Arg 
                165                 170                 175     

Leu Arg Ala Glu Ser Ala Trp Glu Lys Leu Leu Ile Pro Ala Phe Val 
            180                 185                 190         

Tyr Phe Phe Ala Lys Leu Tyr Pro Phe Ala Trp Val Ala His Pro Arg 
        195                 200                 205             

Arg Arg Thr Ala Ala Ala Ala Gly Gly Cys Val Leu Val Arg Arg Arg 
    210                 215                 220                 

Leu Leu Pro Thr Pro Pro Gly Leu Glu Ala Ile Arg Asp Ala Val Ile 
225                 230                 235                 240 

Asp Asp Cys Ala Leu Ala Arg Ile Val Ala Asp Gly Gly Gly Arg Leu 
                245                 250                 255     

Trp Leu Gly Leu Gly Asp Asp Val Val Ser Val Arg Ala Tyr Gly Thr 
            260                 265                 270         

Leu Gly Glu Ile Trp Arg Met Ile Ala Arg Thr Ala Phe Val Gln Leu 
        275                 280                 285             

Arg Phe Ser Thr Val Leu Leu Leu Gly Thr Ala Leu Gly Met Leu Leu 
    290                 295                 300                 

Leu Tyr Ala Val Pro Pro Ala Ala Ala Ile Ala Gly Leu Val Gly Leu 
305                 310                 315                 320 

Leu Ala Gly Ala Pro Gly Ser Leu Ala Ala Leu Cys Leu Gly Gly Leu 
                325                 330                 335     

Ala Tyr Ala Ile Leu Ala Ser Thr Phe Val Pro Met Leu Arg Trp Tyr 
            340                 345                 350         

Arg Leu Ser Pro Ala Arg Ser Ala Leu Leu Pro Leu Ala Gly Val Leu 
        355                 360                 365             

Tyr Thr Leu Met Thr Leu Asp Ser Ala Arg Arg Phe Trp Leu Arg Thr 
    370                 375                 380                 

Gly Asp His Trp Lys Gly Arg Pro Tyr Glu Met Arg Arg Pro 
385                 390                 395             

<210>   81
<211>   1197
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 70

<400>   81
atgacggcgc tggcttgggc cgcggccgta agcctcgcgg cgtggatctt cctgcttttc       60

gggcgcggct tctattggcg cacggcgctc tccatgaaca ccgcaaggat ggcggccgag      120

gccagggcgc cccgcgcgtg gccggccgtg tgggccgtgg tgcccgcgcg caacgaggcg      180

gacgtcttgc cgaggacgct tccgacgctt ctctcgcagg cgtaccccgg tgagttccac      240

gtcgtgctcg tggacgatca cagcacagac ggcacggcgg aggtggccga gcgccttgcg      300

tcggagctta ggctcgcgca tcgtctgcgc gtggtgcgcg cggatgcgct tccgcctggg      360

tgggcgggca aggtgtgggc catgcagaat ggtctcaggc acgtgccgga cgatgcggcg      420

tacgtgctgt tcacggacgc ggacatctcg cattcaccga cgagcgtcca ggccctcgtg      480

gcgcgggccg agcgagacgg gttggacctc gtctcgctca tggttcggct cagggccgag      540

agcgcatggg aaaagctcct cattccagcg ttcgtctact tcttcgcgaa gctgtacccg      600

ttcgcgtggg tcgctcaccc taggaaaagg accgcggccg cggcgggcgg atgcgtgctc      660

gtcaggcgcc gcctgttgcc cacgcccccg gggcttgagg ccattcgcga cgccgtgatc      720

gacgactgtg cgctcgctcg gctcgtggcg gatggcggcg ggcgcctctg gctcgggctt      780

ggcgacgacg tggtgagcgt gcgggcgtac ggaaccctcg gcgaaatctg gcggatgatt      840

gcgcgcaccg cgttcgtgca gctgcggttc tccaccgtgc tcctcttggg caccgccctc      900

ggcatgctcc tcttgtacgc cgtgccaccc gctgccgcaa tcgccggcct cgtgggtctt      960

ctggcgggcg cgccggggag cctcgccgct ttgtgccttg gcgggctcgc gtacgccatc     1020

ctcgcctcga ccttcgtgcc gatgctccgg tggtaccgcc tgtctccggc gcgatccgcc     1080

ctgcttccct tggccggcgt cctgtacacc ctcatgaccc tcgactccgc caggcggttc     1140

tggctccgca cgggcgatca ctggaagggt cggccgtacg aaatgcgccg cccgtga        1197


<210>   82
<211>   1197
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 70

<400>   82
atgacggcgc tggcttgggc cgcggccgta agcctcgcgg cgtggatctt cctgcttttc       60

gggcgcggct tctattggcg cacggcgctc tccatgaaca ccgcaaggat ggcggccgag      120

gccagggcgc cccgcgcgtg gccggccgtg tgggccgtgg tgcccgcgcg caacgaggcg      180

gacgtcttgc cgaggacgct tccgacgctt ctctcgcagg cgtaccccgg tgagttccac      240

gtcgtgctcg tggacgatca cagcacagac ggcacggcgg aggtggccga gcgccttgcg      300

tcggagctta ggctcgcgca tcgtctgcgc gtggtgcgcg cggatgcgct tccgcctggg      360

tgggcgggca aggtgtgggc catgcagaat ggtctcaggc acgtgccgga cgatgcggcg      420

tacgtgctgt tcacggacgc ggacatctcg cattcaccga cgagcgtcca ggccctcgtg      480

gcgcgggccg agcgagacgg gttggacctc gtctcgctca tggttcggct cagggccgag      540

agcgcatggg aaaagctcct cattccagcg ttcgtctact tcttcgcgaa gctgtacccg      600

ttcgcgtggg tcgctcaccc taggcgaagg accgcggccg cggcgggcgg atgcgtgctc      660

gtcaggcgcc gcctgttgcc cacgcccccg gggcttgagg ccattcgcga cgccgtgatc      720

gacgactgtg cgctcgctcg gctcgtggcg gatggcggcg ggcgcctctg gctcgggctt      780

ggcgacgacg tggtgagcgt gcgggcgtac ggaaccctcg gcgaaatctg gcggatgatt      840

gcgcgcaccg cgttcgtgca gctgcggttc tccaccgtgc tcctcttggg caccgccctc      900

ggcatgctcc tcttgtacgc cgtgccaccc gctgccgcaa tcgccggcct cgtgggtctt      960

ctggcgggcg cgccggggag cctcgccgct ttgtgccttg gcgggctcgc gtacgccatc     1020

ctcgcctcga ccttcgtgcc gatgctccgg tggtaccgcc tgtctccggc gcgatccgcc     1080

ctgcttccct tggccggcgt cctgtacacc ctcatgaccc tcgactccgc caggcggttc     1140

tggctccgca cgggcgatca ctggaagggt cggccgtacg atatgcgccg cccgtga        1197


<210>   83
<211>   1197
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 70

<400>   83
atgacggcgc tggcttgggc cgcggccgta agcctcgcgg cgtggatctt cctgcttttc       60

gggcgcggct tctattggcg cacggcgctc tccatgaaca ccgcaaggat ggcggccgag      120

gccagggcgc cccgcgcgtg gccggccgtg tgggccgtgg tgcccgcgcg caacgaggcg      180

gacgtcttgc cgaggacgct tccgacgctt ctctcgcagg cgtaccccgg tgagttccac      240

gtcgtgctcg tggacgatca cagcacagac ggcacggcgg aggtggccga gcgccttgcg      300

tcggagctta ggctcgcgca tcgtctgcgc gtggtgcgcg cggatgcgct tccgcctggg      360

tgggcgggca aggtgtgggc catgcagaat ggtctcaggc acgtgccgga cgatgcggcg      420

tacgtgctgt tcacggacgc ggacatctcg cattcaccga cgagcgtcca ggccctcgtg      480

gcgcgggccg agcgagacgg gttggacctc gtctcgctca tggttcggct cagggccgag      540

agcgcatggg aaaagctcct cattccagcg ttcgtctact tcttcgcgaa gctgtacccg      600

ttcgcgtggg tcgctcaccc taggcgaagg accgcggccg cggcgggcgg atgcgtgctc      660

gtcaggcgcc gcctgttgcc cacgcccccg gggcttgagg ccattcgcga cgccgtgatc      720

gacgactgtg cgctcgctcg gctcgtggcg gatggcggcg ggcgcatttg gctcgggctt      780

ggcgacgacg tggtgagcgt gcgggcgtac ggaaccctcg gcgaaatctg gcggatgatt      840

gcgcgcaccg cgttcgtgca gctgcggttc tccaccgtgc tcctcttggg caccgccctc      900

ggcatgctcc tcttgtacgc cgtgccaccc gctgccgcaa tcgccggcct cgtgggtctt      960

ctggcgggcg cgccggggag cctcgccgct ttgtgccttg gcgggctcgc gtacgccatc     1020

ctcgcctcga ccttcgtgcc gatgctccgg tggtaccgcc tgtctccggc gcgatccgcc     1080

ctgcttccct tggccggcgt cctgtacacc ctcatgaccc tcgactccgc caggcggttc     1140

tggctccgca cgggcgatca ctggaagggt cggccgtacg aaatgcgccg cccgtga        1197


<210>   84
<211>   1197
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 70

<400>   84
atgacggcgc tggcttgggc cgcggccgta agcctcgcgg cgtggatctt cctgcttttc       60

gggcgcggct tctattggcg cacggcgctc tccatgaaca ccgcaaggat ggcggccgag      120

gccagggcgc cccgcgcgtg gccggccgtg tgggccgtgg tgcccgcgcg caacgaggcg      180

gacgtcttgc cgaggacgct tccgacgctt ctctcgcagg cgtaccccgg tgagttccac      240

gtcgtgctcg tggacgatca cagcacagac ggcacggcgg aggtggccga gcgccttgcg      300

tcggagctta ggctcgcgca tcgtctgcgc gtggtgcgcg cggatgcgct tccgcctggg      360

tgggcgggca aggtgtgggc catgcagaat ggtctcaggc acgtgccgga cgaagcggcg      420

tacgtgctgt tcacggacgc ggacatctcg cattcaccga cgagcgtcca ggccctcgtg      480

gcgcgggccg agcgagacgg gttggacctc gtctcgctca tggttcggct cagggccgag      540

agcgcatggg aaaagctcct cattccagcg ttcgtctact tcttcgcgaa gctgtacccg      600

ttcgcgtggg tcgctcaccc taggcgaagg accgcggccg cggcgggcgg atgcgtgctc      660

gtcaggcgcc gcctgttgcc cacgcccccg gggcttgagg ccattcgcga cgccgtgatc      720

gacgactgtg cgctcgctcg gctcgtggcg gatggcggcg ggcgcctctg gctcgggctt      780

ggcgacgacg tggtgagcgt gcgggcgtac ggaaccctcg gcgaaatctg gcggatgatt      840

gcgcgcaccg cgttcgtgca gctgcggttc tccaccgtgc tcctcttggg caccgccctc      900

ggcatgctcc tcttgtacgc cgtgccaccc gctgccgcaa tcgccggcct cgtgggtctt      960

ctggcgggcg cgccggggag cctcgccgct ttgtgccttg gcgggctcgc gtacgccatc     1020

ctcgcctcga ccttcgtgcc gatgctccgg tggtaccgcc tgtctccggc gcgatccgcc     1080

ctgcttccct tggccggcgt cctgtacacc ctcatgaccc tcgactccgc caggcggttc     1140

tggctccgca cgggcgatca ctggaagggt cggccgtacg aaatgcgccg cccgtga        1197


<210>   85
<211>   1197
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 70

<400>   85
atgacggcgc tggcttgggc cgcggccgta agcctcgcgg cgtggatctt cctgcttttc       60

gggcgcggct tctattggcg cacggcgctc tccatgaaca ccgcaaggat ggcggccgag      120

gccagggcgc cccgcgcgtg gccggccgtg tgggccgtgg tgcccgcgcg caacgaggcg      180

gacgtcttgc cgaggacgct tccgacgctt ctctcgcagg cgtaccccgg tgagttccac      240

gtcgtgctcg tggacgatca cagcacagac ggcacggcgg aggtggccga gcgccttgcg      300

tcggagctta ggctcgcgca tcgtctgcgc gtggtgcgcg cggatgcgct tccgcctggg      360

tgggcgggca aggtgtgggc catgcagaat ggtctcaggc acgtgccgga cgatgcggcg      420

tacgtgctgt tcacggacgc ggacatctcg cattcaccga cgagcgtcca ggccctcgtg      480

gcgcgggccg agcgagacgg gttggacctc gtctcgctca tggttcggct cagggccgag      540

agcgcatggg aaaagctcct cattccagcg ttcgtctact tcttcgcgaa gctgtacccg      600

ttcgcgtggg tcgctcaccc taggcgaagg accgcggccg cggcgggcgg atgcgtgctc      660

gtcaggcgcc gcctgttgcc cacgcccccg gggcttgagg ccattcgcga cgccgtgatc      720

gacgactgtg cgctcgctcg gattgtggcg gatggcggcg ggcgcctctg gctcgggctt      780

ggcgacgacg tggtgagcgt gcgggcgtac ggaaccctcg gcgaaatctg gcggatgatt      840

gcgcgcaccg cgttcgtgca gctgcggttc tccaccgtgc tcctcttggg caccgccctc      900

ggcatgctcc tcttgtacgc cgtgccaccc gctgccgcaa tcgccggcct cgtgggtctt      960

ctggcgggcg cgccggggag cctcgccgct ttgtgccttg gcgggctcgc gtacgccatc     1020

ctcgcctcga ccttcgtgcc gatgctccgg tggtaccgcc tgtctccggc gcgatccgcc     1080

ctgcttccct tggccggcgt cctgtacacc ctcatgaccc tcgactccgc caggcggttc     1140

tggctccgca cgggcgatca ctggaagggt cggccgtacg aaatgcgccg cccgtga        1197


<210>   86
<211>   526
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   86
Met Asp Pro Asn Gly Arg Phe Ala Ser Trp Gly Arg Thr Pro Ile Asp 
                5                   10                  15      

Val Arg Val Val Ser Lys His Val Glu Ile Gly Phe Pro Arg Leu Pro 
            20                  25                  30          

Met Met Arg Tyr Thr Phe Leu Gly Ser Ser Arg Arg Ile Ala Gly Gly 
        35                  40                  45              

Pro Met Phe Arg Thr Tyr Gln Glu Leu Phe Arg Arg Ile Phe Ile Ala 
    50                  55                  60                  

Thr Asp Ala Ala Ile Val Val Val Ser Phe Leu Leu Ala Trp Trp Leu 
65                  70                  75                  80  

Lys Phe Asp Ser Gly Trp Ile Pro His Ala Gly His Leu Pro Leu Leu 
                85                  90                  95      

Tyr Tyr Arg Gly Pro Leu Leu Ile Ala Val Ile Val Phe Val Leu Ala 
            100                 105                 110         

Asn Gly Val Ala Arg Leu Tyr Glu Pro Met Arg Ala Lys Ser Leu Phe 
        115                 120                 125             

Tyr Glu Ala Tyr Ser Val Ala Lys Gly Val Ile Leu Gly Thr Ile Val 
    130                 135                 140                 

Leu Met Ala Ala Leu Tyr Phe Ala Lys Met Gln Glu Phe Ser Arg Asp 
145                 150                 155                 160 

Val Ile Ala Leu Phe Thr Gly Ile Asn Phe Gly Leu Met Val Gly Glu 
                165                 170                 175     

Arg Ile Val Val Arg Ser Val Leu Arg Ser Leu Arg Arg Arg Gly Leu 
            180                 185                 190         

Asn Gln Arg Phe Leu Leu Ile Val Gly Trp Ser Ala Ala Thr Arg Arg 
        195                 200                 205             

Phe Leu Glu Ala Leu Glu Ala Gln Pro Trp Phe Gly Tyr Arg Val Ile 
    210                 215                 220                 

Gly Tyr Leu Arg Tyr Glu Gly Asp Asp Ala Ser Arg Ala Thr Val Pro 
225                 230                 235                 240 

Cys Ile Gly Ala Val Asp Asp Ile Arg Cys Val Leu Glu Glu His Leu 
                245                 250                 255     

Val Asp Gln Val Val Ile Ala Ala Pro Arg Asp Arg Val Gly Asp Leu 
            260                 265                 270         

Ala Glu Val Ile Ser Ala Cys Glu Ala Val Gly Val Gln Ser Leu Ile 
        275                 280                 285             

Leu Pro Asp Tyr Phe Asp Leu Leu Pro Ala Arg Pro Arg Phe Glu Thr 
    290                 295                 300                 

Phe Gly Asp Val Pro Leu Ile Asp Thr Arg His Val Pro Leu Asp Asp 
305                 310                 315                 320 

Ala Val Asn Ala Phe Leu Lys Arg Ala Phe Asp Ile Val Phe Ser Leu 
                325                 330                 335     

Gly Val Leu Ile Gly Leu Ser Pro Leu Leu Val Ala Ile Ala Ile Ala 
            340                 345                 350         

Val Lys Leu Ser Ser Pro Gly Pro Val Leu Tyr Val Gln Glu Arg Val 
        355                 360                 365             

Gly Lys Asn Arg Arg Thr Phe Lys Met Tyr Lys Phe Arg Thr Met Tyr 
    370                 375                 380                 

Trp Asp Pro Gly Ala Asp Arg Ala Glu Arg Asp Cys Ala Glu Glu Ala 
385                 390                 395                 400 

Asp Leu Arg Ser Ala Gly Trp Thr Val Lys Gly Asp Pro Arg Arg Thr 
                405                 410                 415     

Arg Val Gly Ala Phe Leu Arg Arg Thr Ser Leu Asp Glu Leu Pro Gln 
            420                 425                 430         

Phe Trp Asn Val Leu Lys Gly Asp Met Ser Val Ile Gly Pro Arg Pro 
        435                 440                 445             

Glu Arg Pro Val Phe Val Glu Arg Phe Arg Glu Glu Val Pro Arg Tyr 
    450                 455                 460                 

Met Val Lys His Arg Val Arg Pro Gly Ile Thr Gly Trp Ala Gln Val 
465                 470                 475                 480 

His Gly Trp Arg Gly Asp Thr Ser Ile Ala Glu Arg Ile Arg Phe Asp 
                485                 490                 495     

Ile Glu Tyr Ile Glu Asn Trp Ser Phe Trp Leu Asp Leu Lys Ile Val 
            500                 505                 510         

Trp Lys Thr Ile Lys His Gly Phe Val Asn Glu Asn Ala Tyr 
        515                 520                 525     

<210>   87
<211>   1581
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   87
atggacccga acggtaggtt tgcaagttgg ggaagaacgc ccatcgacgt aagggtggtg       60

tcaaaacatg tcgaaatagg cttccctcgc ttgccaatga tgcgctatac tttccttggt      120

agttcacgcc gcatcgcggg tggtcctatg tttcgcactt atcaggagct gttccggcga      180

atcttcatcg ctaccgacgc ggccatcgtc gtcgtgagtt ttctactcgc atggtggctc      240

aagtttgatt ctgggtggat tccgcacgcc ggccatctcc cactcctcta ttatcgaggg      300

ccgcttctca tcgccgtgat cgtattcgtg cttgcaaacg gtgtagcgcg gctctacgaa      360

ccgatgcgcg cgaagagctt gttctacgag gcgtacagcg tagcgaaggg cgtcatcctc      420

gggacaattg tcctcatggc tgccctctat ttcgcgaaga tgcaggagtt ttcgcgagac      480

gtcatcgcgc tctttactgg catcaacttc gggctcatgg tgggagagcg gatcgtcgtg      540

cgctccgtgc tgcgcagcct gcgccgccga gggttgaatc agcgatttct cctcatcgtg      600

ggctggagtg cagcgacgcg tcgcttcctc gaggccctgg aggcccagcc gtggttcggt      660

taccgtgtca taggctatct ccgttacgaa ggtgatgatg cgtcgcgcgc gacagtgcca      720

tgcatcgggg cggttgacga cattcgttgc gtgcttgagg agcacctcgt cgatcaggtg      780

gtcatcgcgg caccgcggga tcgagtgggc gatctcgccg aagtgatttc cgcctgcgaa      840

gctgtagggg tccagtcgct gatcttgccg gattacttcg atctcctgcc ggccaggccc      900

cgttttgaaa cctttggaga tgtgccgctg attgacacgc gccatgtgcc gctggacgat      960

gcggtgaacg ccttcctgaa gcgcgcgttc gacatcgtgt tcagtctggg ggtcctgatt     1020

ggtctgtcgc cgctgttggt ggccattgcg attgcggtga agctttcgtc gccagggcca     1080

gtgctgtacg tgcaggagcg agtgggcaaa aatcgacgga catttaagat gtacaagttc     1140

cgaacgatgt actgggatcc cggggcggac cgtgcggagc gggattgcgc ggaagaggcg     1200

gacctgcgga gcgctggttg gacggtgaaa ggcgatccgc ggcggactcg cgtgggagcg     1260

ttcctacgtc gcacgagttt ggacgagctc cctcagttct ggaacgtgct gaagggagac     1320

atgagcgtca ttgggccgcg cccggagcgc cccgtcttcg tcgagcgatt ccgagaagag     1380

gtgccgcgtt acatggtcaa gcaccgcgtg agaccaggta tcaccgggtg ggcgcaggtg     1440

catggatggc gcggagatac ttcgattgct gaacggattc gatttgacat tgagtacatc     1500

gaaaactggt cattctggct tgatctcaag attgtgtgga agactatcaa acatgggttt     1560

gtgaatgaga atgcgtattg a                                               1581


<210>   88
<211>   468
<212>   PRT
<213>   Geobacillus stearothermophilus

<400>   88
Val Ile Arg Gly Arg Glu Arg Phe Leu Thr Lys Leu Tyr Ala Phe Val 
                5                   10                  15      

Asp Phe Ala Met Met Gln Gly Ala Phe Phe Leu Ala Trp Val Leu Lys 
            20                  25                  30          

Phe Lys Val Phe His Asn Gly Val Gly Gly His Leu Pro Leu Glu Asp 
        35                  40                  45              

Tyr Leu Phe Trp Ser Phe Val Tyr Gly Ala Ile Ala Ile Val Ile Gly 
    50                  55                  60                  

Tyr Leu Val Glu Leu Tyr Ala Pro Lys Arg Lys Glu Lys Phe Ser Asn 
65                  70                  75                  80  

Glu Leu Ala Lys Val Leu Gln Val His Thr Leu Ser Met Phe Val Leu 
                85                  90                  95      

Leu Ser Val Leu Phe Thr Phe Lys Thr Val Asp Val Ser Arg Ser Phe 
            100                 105                 110         

Leu Leu Leu Tyr Phe Ala Trp Asn Leu Ile Leu Val Ser Ile Tyr Arg 
        115                 120                 125             

Tyr Ile Val Lys Gln Ser Leu Arg Thr Leu Arg Lys Lys Gly Tyr Asn 
    130                 135                 140                 

Lys Gln Phe Val Leu Ile Ile Gly Ala Gly Ser Ile Gly Arg Lys Tyr 
145                 150                 155                 160 

Phe Glu Asn Leu Gln Met His Pro Glu Phe Gly Leu Glu Val Val Gly 
                165                 170                 175     

Phe Leu Asp Asp Phe Arg Thr Lys His Ala Pro Glu Phe Ala His Tyr 
            180                 185                 190         

Lys Pro Ile Ile Gly Gln Thr Ala Asp Leu Glu His Val Leu Ser His 
        195                 200                 205             

Gln Leu Ile Asp Glu Val Ile Val Ala Leu Pro Leu Gln Ala Tyr Pro 
    210                 215                 220                 

Lys Tyr Arg Glu Ile Ile Ala Val Cys Glu Lys Met Gly Val Arg Val 
225                 230                 235                 240 

Ser Ile Ile Pro Asp Phe Tyr Asp Ile Leu Pro Ala Ala Pro His Phe 
                245                 250                 255     

Glu Ile Phe Gly Asp Leu Pro Ile Ile Asn Val Arg Asp Val Pro Leu 
            260                 265                 270         

Asp Glu Leu Arg Asn Arg Val Leu Lys Arg Ser Phe Asp Ile Val Phe 
        275                 280                 285             

Ser Leu Val Ala Ile Ile Val Thr Ser Pro Ile Met Leu Leu Ile Ala 
    290                 295                 300                 

Ile Gly Ile Lys Leu Thr Ser Pro Gly Pro Ile Ile Phe Lys Gln Glu 
305                 310                 315                 320 

Arg Val Gly Leu Asn Arg Arg Thr Phe Tyr Met Tyr Lys Phe Arg Ser 
                325                 330                 335     

Met Lys Pro Met Pro Gln Ser Val Ser Asp Thr Gln Trp Thr Val Glu 
            340                 345                 350         

Ser Asp Pro Arg Arg Thr Lys Phe Gly Ala Phe Leu Arg Lys Thr Ser 
        355                 360                 365             

Leu Asp Glu Leu Pro Gln Phe Phe Asn Val Leu Lys Gly Asp Met Ser 
    370                 375                 380                 

Ile Val Gly Pro Arg Pro Glu Arg Pro Phe Phe Val Glu Lys Phe Lys 
385                 390                 395                 400 

Lys Glu Ile Pro Lys Tyr Met Ile Lys His His Val Arg Pro Gly Ile 
                405                 410                 415     

Thr Gly Trp Ala Gln Val Cys Gly Leu Arg Gly Asp Thr Ser Ile Gln 
            420                 425                 430         

Glu Arg Ile Glu His Asp Leu Phe Tyr Ile Glu Asn Trp Ser Leu Trp 
        435                 440                 445             

Leu Asp Ile Lys Ile Ile Leu Leu Thr Ile Thr Asn Gly Leu Val Asn 
    450                 455                 460                 

Lys Asn Ala Tyr 
465             

<210>   89
<211>   459
<212>   PRT
<213>   Geobacillus tepidamans

<400>   89
Arg Gly Arg Glu Arg Phe Leu Thr Lys Leu Tyr Ala Phe Val Asp Phe 
                5                   10                  15      

Ala Met Met Gln Gly Ala Phe Phe Leu Ala Trp Val Leu Lys Phe Lys 
            20                  25                  30          

Val Phe His Asp Gly Val Gly Gly His Leu Pro Leu Glu Asp Tyr Trp 
        35                  40                  45              

Phe Trp Ser Phe Val Tyr Gly Ala Ile Ala Ile Val Ile Gly Tyr Leu 
    50                  55                  60                  

Val Glu Leu Tyr Ala Pro Lys Arg Lys Glu Lys Phe Ser Asn Glu Leu 
65                  70                  75                  80  

Ala Lys Val Leu Gln Val His Thr Leu Ser Met Phe Ile Leu Leu Ser 
                85                  90                  95      

Val Leu Phe Thr Phe Lys Thr Val Asp Val Ser Arg Ser Phe Leu Leu 
            100                 105                 110         

Leu Tyr Phe Ala Trp Asn Leu Thr Leu Ala Ser Ile Tyr Arg Tyr Val 
        115                 120                 125             

Val Lys Gln Ser Leu Arg Lys Leu Arg Lys Lys Trp Tyr Asn Lys Gln 
    130                 135                 140                 

Phe Val Leu Ile Ile Gly Ala Gly Ser Ile Gly Arg Lys Tyr Phe Glu 
145                 150                 155                 160 

Asn Leu Gln Met His Pro Glu Tyr Gly Leu Glu Val Val Gly Phe Leu 
                165                 170                 175     

Asp Asp Phe Arg Thr Lys His Ala Pro Glu Phe Ala His Tyr Lys Pro 
            180                 185                 190         

Ile Ile Gly Gln Thr Ala Asp Leu Glu His Val Leu Ser His Gln Leu 
        195                 200                 205             

Ile Asp Glu Val Ile Val Ala Leu Pro Leu Gln Ala Tyr Pro Lys Tyr 
    210                 215                 220                 

Arg Glu Ile Ile Ala Val Cys Glu Lys Met Gly Val Arg Val Ser Ile 
225                 230                 235                 240 

Ile Pro Asp Phe Tyr Asp Met Leu Pro Ala Val Pro His Phe Glu Ile 
                245                 250                 255     

Phe Gly Asp Leu Pro Ile Ile Asn Val Arg Asp Val Pro Leu Asp Glu 
            260                 265                 270         

Leu Arg Asn Arg Ile Leu Lys Arg Ser Phe Asp Val Val Phe Ser Leu 
        275                 280                 285             

Val Ala Ile Ile Val Thr Ser Pro Ile Met Leu Leu Ile Ala Ile Gly 
    290                 295                 300                 

Ile Lys Leu Thr Ser Pro Gly Pro Ile Ile Phe Lys Gln Glu Arg Val 
305                 310                 315                 320 

Gly Leu Asn Arg Arg Thr Phe Tyr Met Tyr Lys Phe Arg Ser Met Lys 
                325                 330                 335     

His Leu Pro Gln Ser Val Ser Asp Thr Gln Trp Thr Val Glu Asn Asp 
            340                 345                 350         

Pro Arg Arg Thr Lys Phe Gly Ala Phe Leu Arg Lys Thr Ser Leu Asp 
        355                 360                 365             

Glu Leu Pro Gln Phe Phe Asn Val Leu Lys Gly Asp Met Ser Val Val 
    370                 375                 380                 

Gly Pro Arg Pro Glu Arg Pro Tyr Phe Val Glu Lys Phe Lys Glu Glu 
385                 390                 395                 400 

Ile Pro Lys Tyr Met Ile Lys His His Val Arg Pro Gly Ile Thr Gly 
                405                 410                 415     

Trp Ala Gln Val Cys Gly Leu Arg Gly Asp Thr Ser Ile Lys Ala Arg 
            420                 425                 430         

Ile Glu His Asp Ile Phe Tyr Ile Glu Asn Trp Ser Leu Leu Phe Asp 
        435                 440                 445             

Ile Lys Ile Ile Phe Lys Thr Ile Ser Asn Gly 
    450                 455                 

<210>   90
<211>   463
<212>   PRT
<213>   Desulfitobacterium hafniense DCB-2

<400>   90
Met Ile Arg Glu Asn Gln Lys Thr Leu Asn Met Ile Gln Val Ile Leu 
                5                   10                  15      

Asp Leu Ala Ile Val Val Ile Ala Leu Ala Leu Ala Tyr Trp Leu Arg 
            20                  25                  30          

Phe Ala Asn Tyr Glu Gly Ser His Leu Lys Phe Glu Ser Tyr Val Pro 
        35                  40                  45              

Thr Leu Val Leu Leu Val Pro Leu His Phe Phe Leu Tyr Tyr Leu Leu 
    50                  55                  60                  

Gly Leu Tyr Glu Ala Arg Arg Arg Lys Ser Leu Ser Phe Glu Val Gly 
65                  70                  75                  80  

Lys Ile Ile Gln Ala Asn Phe Leu Ser Thr Met Ile Leu Phe Thr Leu 
                85                  90                  95      

Leu Tyr Ile Ile Lys Glu Ile His Tyr Ser Arg Gln Val Leu Ile Tyr 
            100                 105                 110         

Phe Val Ile Phe Thr Gly Thr Leu Thr Ile Ala Glu Arg Met Ala Leu 
        115                 120                 125             

Arg Ala Ile Leu Asn Asn Ile Arg Glu Lys Gly Tyr Asn Lys Lys His 
    130                 135                 140                 

Val Leu Ile Ile Gly Thr Gly Arg Leu Ala Lys Arg Leu Val Asn Ala 
145                 150                 155                 160 

Leu Gln Glu Asn Arg Tyr Leu Gly Tyr Glu Ile Leu Gly Ile Val Gly 
                165                 170                 175     

Glu Asn Thr Ala Val Gly Lys Lys Leu Ala Gly Val Thr Val Ala Gly 
            180                 185                 190         

Ala Ile Ser Asp Leu Glu Asn Ile Ile Met Glu Ser Lys Ile Asp Glu 
        195                 200                 205             

Ile Phe Ile Thr Ile Ser Thr Lys Asp Tyr Asp Leu Phe Arg Asn Ile 
    210                 215                 220                 

Ile Lys Ile Cys Glu Lys Ser Gly Val Arg Thr Gln Ile Val Pro Asp 
225                 230                 235                 240 

Tyr Ala Arg Phe Ile Pro Ala Lys Pro Gln Met Asp Glu Ile Glu Gly 
                245                 250                 255     

Ile Pro Leu Ile Asn Ile Arg His Val Pro Leu Asp Asn Phe Leu Lys 
            260                 265                 270         

Ala Phe Ala Lys Arg Val Phe Asp Val Ala Val Ser Phe Val Gly Leu 
        275                 280                 285             

Val Val Cys Leu Pro Leu Phe Leu Ile Ile Ile Ile Gly Ile Lys Leu 
    290                 295                 300                 

Asp Ser Pro Gly Pro Ile Ile Phe Ser Gln Glu Arg Val Gly Leu Asn 
305                 310                 315                 320 

Lys Lys Asn Phe Met Met Tyr Lys Phe Arg Thr Met Lys Glu Gln Ser 
                325                 330                 335     

Ile Glu Glu Ser Asp Lys Glu Trp Thr Thr Glu Asn Asp Asp Arg Lys 
            340                 345                 350         

Thr Arg Leu Gly Asn Leu Leu Arg Lys Thr Ser Leu Asp Glu Leu Pro 
        355                 360                 365             

Gln Leu Trp Asn Val Phe Lys Gly Asp Met Ser Leu Val Gly Pro Arg 
    370                 375                 380                 

Pro Glu Arg Pro Phe Phe Val Glu Gln Phe Lys Glu Lys Ile Pro Arg 
385                 390                 395                 400 

Tyr Met Val Lys His His Val Arg Pro Gly Ile Thr Gly Trp Ala Gln 
                405                 410                 415     

Val Asn Gly Trp Arg Gly Asp Thr Ser Ile Arg Lys Arg Ile Glu Cys 
            420                 425                 430         

Asp Ile Tyr Tyr Ile Glu Asn Trp Thr Phe Met Phe Asp Leu Lys Ile 
        435                 440                 445             

Leu Val Met Thr Val Phe Lys Gly Phe Val Asn Arg Asn Ala Tyr 
    450                 455                 460             

<210>   91
<211>   463
<212>   PRT
<213>   Desulfitobacterium hafniense Y51

<400>   91
Met Ile Arg Glu Asn Gln Lys Thr Leu Asn Met Ile Gln Val Ile Leu 
                5                   10                  15      

Asp Leu Gly Ile Val Val Ile Ala Leu Ala Leu Ala Tyr Trp Tyr Arg 
            20                  25                  30          

Phe Ser Asn Tyr Glu Gly Ser Tyr Leu Lys Phe Glu Ser Tyr Val Pro 
        35                  40                  45              

Thr Leu Val Leu Leu Val Pro Leu His Phe Phe Leu Tyr Tyr Leu Leu 
    50                  55                  60                  

Gly Leu Tyr Glu Ala Arg Arg Arg Lys Ser Phe Ser Phe Glu Val Gly 
65                  70                  75                  80  

Lys Ile Ile Gln Ala Asn Leu Leu Ser Thr Met Ile Leu Phe Thr Leu 
                85                  90                  95      

Leu Tyr Ile Ile Lys Glu Ile Asp Tyr Ser Arg Gln Val Leu Ile Tyr 
            100                 105                 110         

Phe Ile Ile Leu Thr Gly Thr Leu Thr Ile Ala Glu Arg Val Ala Leu 
        115                 120                 125             

Arg Ala Ile Leu Asn Asn Ile Arg Glu Lys Gly Tyr Asn Lys Lys His 
    130                 135                 140                 

Val Leu Ile Ile Gly Thr Gly Arg Leu Ala Lys Arg Leu Val Asn Ala 
145                 150                 155                 160 

Leu Gln Glu Asn Arg Tyr Leu Gly Tyr Glu Ile Leu Gly Ile Val Gly 
                165                 170                 175     

Glu Asn Thr Ala Val Gly Lys Lys Leu Ala Gly Val Thr Val Ala Gly 
            180                 185                 190         

Ala Ile Ser Asp Leu Glu Asn Ile Ile Met Glu Ser Lys Ile Asp Glu 
        195                 200                 205             

Ile Phe Ile Thr Ile Ser Thr Lys Glu Tyr Asp Leu Phe Arg Asn Ile 
    210                 215                 220                 

Ile Lys Ile Cys Glu Lys Ser Gly Val Arg Thr Gln Ile Val Pro Asp 
225                 230                 235                 240 

Tyr Ala Arg Phe Ile Pro Ala Lys Pro Gln Met Asp Glu Val Asp Gly 
                245                 250                 255     

Ile Pro Leu Ile Asn Ile Arg His Val Pro Leu Asp Asn Phe Leu Lys 
            260                 265                 270         

Ser Phe Ala Lys Arg Ala Phe Asp Val Ala Val Ser Phe Val Gly Leu 
        275                 280                 285             

Ile Ile Cys Leu Pro Ile Phe Leu Val Ile Ile Ile Gly Ile Lys Leu 
    290                 295                 300                 

Asp Ser Pro Gly Ala Val Ile Phe Ser Gln Glu Arg Val Gly Leu Asn 
305                 310                 315                 320 

Lys Lys Asn Phe Met Met Tyr Lys Phe Arg Thr Met Arg Met Gln Ser 
                325                 330                 335     

Ala Glu Glu Ser Asp Lys Glu Trp Thr Thr Lys Glu Asp Asn Arg Lys 
            340                 345                 350         

Thr Arg Leu Gly Asn Ile Leu Arg Lys Thr Ser Leu Asp Glu Leu Pro 
        355                 360                 365             

Gln Leu Trp Asn Val Phe Lys Gly Asp Met Ser Leu Val Gly Pro Arg 
    370                 375                 380                 

Pro Glu Arg Pro Phe Phe Val Glu Gln Phe Lys Glu Lys Ile Pro Arg 
385                 390                 395                 400 

Tyr Met Ile Lys His His Val Arg Pro Gly Ile Thr Gly Trp Ala Gln 
                405                 410                 415     

Val Asn Gly Trp Arg Gly Asp Thr Ser Ile Arg Lys Arg Ile Glu Cys 
            420                 425                 430         

Asp Ile Tyr Tyr Ile Glu Asn Trp Thr Phe Met Phe Asp Leu Lys Ile 
        435                 440                 445             

Leu Val Met Thr Val Phe Lys Gly Phe Val Asn Arg Asn Ala Tyr 
    450                 455                 460             

<210>   92
<211>   462
<212>   PRT
<213>   Dorea formicigenerans ATCC 27755

<400>   92
Gln Lys Leu Phe Asn Arg Leu His Val Leu Ile Asp Ala Leu Ile Ile 
                5                   10                  15      

Ile Phe Ser Tyr Gly Ala Ala Trp Phe Ile Arg Phe Lys Ser Gly Leu 
            20                  25                  30          

Phe Ala Leu Ser Ser Trp Tyr Leu Ser Leu Ser Gln Tyr Met Lys Val 
        35                  40                  45              

Leu Val Phe Val Val Pro Ile Tyr Leu Ile Leu Tyr Tyr Ala Phe Gln 
    50                  55                  60                  

Leu Tyr Thr Pro Lys Arg Gly Gln Gly Arg Arg Ile Glu Ala Trp His 
65                  70                  75                  80  

Ile Val Gln Ala Asn Ile Ile Gly Leu Leu Val Phe Ile Leu Ile Leu 
                85                  90                  95      

Tyr Leu Ala Lys Met Thr Asp Tyr Ser Arg Lys Met Leu Phe Val Phe 
            100                 105                 110         

Phe Cys Val Asn Val Val Ala Glu Ile Gly Phe Arg Asn Val Leu Arg 
        115                 120                 125             

Trp Ile Leu Arg Lys Tyr Arg Lys Gln Gly Tyr Asn Gln Lys His Ile 
    130                 135                 140                 

Leu Leu Val Gly Tyr Ser Arg Ala Ala Glu Gly Tyr Leu Asp Arg Val 
145                 150                 155                 160 

Val Thr His Pro Glu Trp Gly Tyr Ile Val Lys Gly Ile Leu Ala Asp 
                165                 170                 175     

Asn Lys Pro Glu Gly Glu Glu Tyr Arg Gly Ile Lys Ile Leu Gly Gly 
            180                 185                 190         

Thr Asp Lys Leu Ala Glu Ile Leu Pro Gln Asn Gln Leu Asp Glu Ile 
        195                 200                 205             

Val Ile Thr Leu Gly Leu Ala Glu Tyr His Lys Leu Gly Arg Ile Val 
    210                 215                 220                 

Asn Met Cys Glu Lys Ser Gly Val His Thr Lys Phe Val Pro Asp Tyr 
225                 230                 235                 240 

Asn Asn Ile Ile Pro Thr Lys Pro Tyr Thr Glu Asp Leu Met Gly Met 
                245                 250                 255     

Pro Val Ile Asn Ile Arg Arg Val Pro Leu Asn Asn Met Leu Asn Ala 
            260                 265                 270         

Val Ala Lys Arg Cys Val Asp Ile Leu Gly Ala Leu Val Ala Ile Ile 
        275                 280                 285             

Leu Phe Ser Pro Val Met Leu Val Thr Ser Ile Ile Ile Lys Val Thr 
    290                 295                 300                 

Ser Pro Gly Pro Leu Ile Phe Lys Gln Glu Arg Ile Gly Lys His Asn 
305                 310                 315                 320 

Arg Pro Phe Tyr Met Tyr Lys Phe Arg Ser Met Val Val Gln Asp Glu 
                325                 330                 335     

Lys Asp Glu Lys Lys Gly Trp Thr Thr Lys Asn Asp Pro Arg Val Thr 
            340                 345                 350         

Pro Ile Gly Arg Phe Ile Arg Lys Thr Ser Ile Asp Glu Leu Pro Gln 
        355                 360                 365             

Leu Phe Asn Ile Leu Ile Gly Asp Met Ser Leu Val Gly Pro Arg Pro 
    370                 375                 380                 

Glu Arg Pro Gln Phe Val Glu Lys Phe Lys Glu Glu Ile Pro Arg Tyr 
385                 390                 395                 400 

Met Ile Lys His Gln Val Arg Pro Gly Leu Thr Gly Trp Ala Gln Val 
                405                 410                 415     

Asn Gly Tyr Arg Gly Asp Thr Ser Ile Gln Lys Arg Ile Glu Phe Asp 
            420                 425                 430         

Leu Tyr Tyr Ile Glu Asn Trp Thr Met Gly Phe Asp Phe Lys Ile Ile 
        435                 440                 445             

Phe Leu Thr Phe Phe Lys Gly Phe Ile Asn Arg Asn Ala Tyr 
    450                 455                 460         

<210>   93
<211>   526
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 86

<400>   93
Met Asp Pro Asn Gly Arg Phe Ala Ser Trp Gly Arg Thr Pro Ile Asp 
                5                   10                  15      

Val Arg Val Val Ser Lys His Val Glu Ile Gly Phe Pro Arg Leu Pro 
            20                  25                  30          

Met Met Arg Tyr Thr Phe Leu Gly Ser Ser Arg Arg Ile Ala Gly Gly 
        35                  40                  45              

Pro Met Phe Arg Thr Tyr Gln Glu Leu Phe Arg Arg Ile Phe Ile Ala 
    50                  55                  60                  

Thr Asp Ala Ala Ile Val Val Val Ser Phe Leu Leu Ala Trp Trp Leu 
65                  70                  75                  80  

Lys Phe Asp Ser Gly Trp Ile Pro His Ala Gly His Leu Pro Leu Leu 
                85                  90                  95      

Tyr Tyr Arg Gly Pro Leu Leu Ile Ala Val Ile Val Phe Val Leu Ala 
            100                 105                 110         

Asn Gly Val Ala Arg Leu Tyr Glu Pro Met Arg Ala Lys Ser Leu Phe 
        115                 120                 125             

Tyr Glu Ala Tyr Ser Val Ala Lys Gly Val Ile Leu Gly Thr Ile Val 
    130                 135                 140                 

Leu Met Ala Ala Leu Tyr Phe Ala Lys Met Gln Glu Phe Ser Arg Asp 
145                 150                 155                 160 

Val Ile Ala Leu Phe Thr Gly Ile Asn Phe Gly Leu Met Val Gly Glu 
                165                 170                 175     

Arg Ile Val Val Arg Ser Val Leu Arg Ser Leu Arg Arg Arg Gly Leu 
            180                 185                 190         

Asn Gln Arg Phe Leu Leu Ile Val Gly Trp Ser Ala Ala Thr Arg Arg 
        195                 200                 205             

Phe Leu Glu Ala Leu Glu Ala Gln Pro Trp Phe Gly Tyr Arg Val Ile 
    210                 215                 220                 

Gly Tyr Leu Arg Tyr Glu Gly Asp Asp Ala Ser Arg Ala Thr Val Pro 
225                 230                 235                 240 

Cys Ile Gly Ala Val Asp Asp Ile Lys Cys Val Leu Glu Glu His Leu 
                245                 250                 255     

Val Asp Gln Val Val Ile Ala Ala Pro Arg Asp Arg Val Gly Asp Leu 
            260                 265                 270         

Ala Glu Val Ile Ser Ala Cys Glu Ala Val Gly Val Gln Ser Leu Ile 
        275                 280                 285             

Leu Pro Asp Tyr Phe Asp Leu Leu Pro Ala Arg Pro Arg Phe Glu Thr 
    290                 295                 300                 

Phe Gly Asp Val Pro Leu Ile Asp Thr Arg His Val Pro Leu Asp Asp 
305                 310                 315                 320 

Ala Val Asn Ala Phe Leu Lys Arg Ala Phe Asp Ile Val Phe Ser Leu 
                325                 330                 335     

Gly Val Leu Ile Gly Leu Ser Pro Leu Leu Val Ala Ile Ala Ile Ala 
            340                 345                 350         

Val Lys Leu Ser Ser Pro Gly Pro Val Leu Tyr Val Gln Glu Arg Val 
        355                 360                 365             

Gly Lys Asn Arg Arg Thr Phe Lys Met Tyr Lys Phe Arg Thr Met Tyr 
    370                 375                 380                 

Trp Asp Pro Gly Ala Asp Arg Ala Glu Arg Asp Cys Ala Glu Glu Ala 
385                 390                 395                 400 

Asp Leu Arg Ser Ala Gly Trp Thr Val Lys Gly Asp Pro Arg Arg Thr 
                405                 410                 415     

Arg Val Gly Ala Phe Leu Arg Arg Thr Ser Leu Asp Glu Leu Pro Gln 
            420                 425                 430         

Phe Trp Asn Val Leu Lys Gly Asp Met Ser Val Ile Gly Pro Arg Pro 
        435                 440                 445             

Glu Arg Pro Val Phe Val Glu Arg Phe Arg Glu Glu Val Pro Arg Tyr 
    450                 455                 460                 

Met Val Lys His Arg Val Arg Pro Gly Ile Thr Gly Trp Ala Gln Val 
465                 470                 475                 480 

His Gly Trp Arg Gly Asp Thr Ser Ile Ala Glu Arg Ile Arg Phe Asp 
                485                 490                 495     

Ile Glu Tyr Ile Glu Asn Trp Ser Phe Trp Leu Asp Leu Lys Ile Val 
            500                 505                 510         

Trp Lys Thr Ile Lys His Gly Phe Val Asn Glu Asn Ala Tyr 
        515                 520                 525     

<210>   94
<211>   526
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 86

<400>   94
Met Asp Pro Asn Gly Arg Phe Ala Ser Trp Gly Arg Thr Pro Ile Asp 
                5                   10                  15      

Val Arg Val Val Ser Lys His Val Glu Leu Gly Phe Pro Arg Leu Pro 
            20                  25                  30          

Met Met Arg Tyr Thr Phe Leu Gly Ser Ser Arg Arg Ile Ala Gly Gly 
        35                  40                  45              

Pro Met Phe Arg Thr Tyr Gln Glu Leu Phe Arg Arg Ile Phe Ile Ala 
    50                  55                  60                  

Thr Asp Ala Ala Ile Val Val Val Ser Phe Leu Leu Ala Trp Trp Leu 
65                  70                  75                  80  

Lys Phe Asp Ser Gly Trp Ile Pro His Ala Gly His Leu Pro Leu Leu 
                85                  90                  95      

Tyr Tyr Arg Gly Pro Leu Leu Ile Ala Val Ile Val Phe Val Leu Ala 
            100                 105                 110         

Asn Gly Val Ala Arg Leu Tyr Glu Pro Met Arg Ala Lys Ser Leu Phe 
        115                 120                 125             

Tyr Glu Ala Tyr Ser Val Ala Lys Gly Val Ile Leu Gly Thr Ile Val 
    130                 135                 140                 

Leu Met Ala Ala Leu Tyr Phe Ala Lys Met Gln Glu Phe Ser Arg Asp 
145                 150                 155                 160 

Val Ile Ala Leu Phe Thr Gly Ile Asn Phe Gly Leu Met Val Gly Glu 
                165                 170                 175     

Arg Ile Val Val Arg Ser Val Leu Arg Ser Leu Arg Arg Arg Gly Leu 
            180                 185                 190         

Asn Gln Arg Phe Leu Leu Ile Val Gly Trp Ser Ala Ala Thr Arg Arg 
        195                 200                 205             

Phe Leu Glu Ala Leu Glu Ala Gln Pro Trp Phe Gly Tyr Arg Val Ile 
    210                 215                 220                 

Gly Tyr Leu Arg Tyr Glu Gly Asp Asp Ala Ser Arg Ala Thr Val Pro 
225                 230                 235                 240 

Cys Ile Gly Ala Val Asp Asp Ile Arg Cys Val Leu Glu Glu His Leu 
                245                 250                 255     

Val Asp Gln Val Val Ile Ala Ala Pro Arg Asp Arg Val Gly Asp Leu 
            260                 265                 270         

Ala Glu Val Ile Ser Ala Cys Glu Ala Val Gly Val Gln Ser Leu Ile 
        275                 280                 285             

Leu Pro Asp Tyr Phe Asp Leu Leu Pro Ala Arg Pro Arg Phe Glu Thr 
    290                 295                 300                 

Phe Gly Asp Val Pro Leu Ile Asp Thr Arg His Val Pro Leu Asp Asp 
305                 310                 315                 320 

Ala Val Asn Ala Phe Leu Lys Arg Ala Phe Asp Ile Val Phe Ser Leu 
                325                 330                 335     

Gly Val Leu Ile Gly Leu Ser Pro Leu Leu Val Ala Ile Ala Ile Ala 
            340                 345                 350         

Val Lys Leu Ser Ser Pro Gly Pro Val Leu Tyr Val Gln Glu Arg Val 
        355                 360                 365             

Gly Lys Asn Arg Arg Thr Phe Lys Met Tyr Lys Phe Arg Thr Met Tyr 
    370                 375                 380                 

Trp Asp Pro Gly Ala Asp Arg Ala Glu Arg Asp Cys Ala Glu Glu Ala 
385                 390                 395                 400 

Asp Leu Arg Ser Ala Gly Trp Thr Val Lys Gly Asp Pro Arg Arg Thr 
                405                 410                 415     

Arg Val Gly Ala Phe Leu Arg Arg Thr Ser Leu Asp Glu Leu Pro Gln 
            420                 425                 430         

Phe Trp Asn Val Leu Lys Gly Asp Met Ser Val Ile Gly Pro Arg Pro 
        435                 440                 445             

Glu Arg Pro Val Phe Val Glu Arg Phe Arg Glu Glu Val Pro Arg Tyr 
    450                 455                 460                 

Met Val Lys His Arg Val Arg Pro Gly Ile Thr Gly Trp Ala Gln Val 
465                 470                 475                 480 

His Gly Trp Arg Gly Asp Thr Ser Ile Ala Glu Arg Ile Arg Phe Asp 
                485                 490                 495     

Ile Glu Tyr Ile Glu Asn Trp Ser Phe Trp Leu Asp Leu Lys Ile Val 
            500                 505                 510         

Trp Lys Thr Ile Lys His Gly Phe Val Asn Glu Asn Ala Tyr 
        515                 520                 525     

<210>   95
<211>   526
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 86

<400>   95
Met Asp Pro Asn Gly Arg Phe Ala Ser Trp Gly Arg Thr Pro Ile Asp 
                5                   10                  15      

Val Arg Val Val Ser Lys His Val Glu Ile Gly Phe Pro Arg Leu Pro 
            20                  25                  30          

Met Met Arg Tyr Thr Phe Leu Gly Ser Ser Arg Arg Ile Ala Gly Gly 
        35                  40                  45              

Pro Met Phe Arg Thr Tyr Gln Glu Leu Phe Arg Arg Ile Phe Ile Ala 
    50                  55                  60                  

Thr Asp Ala Ala Ile Val Val Val Ser Phe Leu Leu Ala Trp Trp Leu 
65                  70                  75                  80  

Lys Phe Asp Ser Gly Trp Ile Pro His Ala Gly His Leu Pro Leu Leu 
                85                  90                  95      

Tyr Tyr Arg Gly Pro Leu Leu Ile Ala Val Ile Val Phe Val Leu Ala 
            100                 105                 110         

Asn Gly Val Ala Arg Leu Tyr Glu Pro Met Arg Ala Lys Ser Leu Phe 
        115                 120                 125             

Tyr Glu Ala Tyr Ser Val Ala Lys Gly Val Ile Leu Gly Thr Ile Val 
    130                 135                 140                 

Leu Met Ala Ala Leu Tyr Phe Ala Lys Met Gln Glu Phe Ser Arg Asp 
145                 150                 155                 160 

Val Ile Ala Leu Phe Thr Gly Ile Asn Phe Gly Leu Met Val Gly Glu 
                165                 170                 175     

Arg Ile Val Val Arg Ser Val Leu Arg Ser Leu Arg Arg Arg Gly Leu 
            180                 185                 190         

Asn Gln Arg Phe Leu Leu Ile Val Gly Trp Ser Ala Ala Thr Arg Arg 
        195                 200                 205             

Phe Leu Glu Ala Leu Glu Ala Gln Pro Trp Phe Gly Tyr Arg Val Ile 
    210                 215                 220                 

Gly Tyr Leu Arg Tyr Glu Gly Asp Asp Ala Ser Arg Ala Thr Val Pro 
225                 230                 235                 240 

Cys Ile Gly Ala Val Glu Asp Ile Arg Cys Val Leu Glu Glu His Leu 
                245                 250                 255     

Val Asp Gln Val Val Ile Ala Ala Pro Arg Asp Arg Val Gly Asp Leu 
            260                 265                 270         

Ala Glu Val Ile Ser Ala Cys Glu Ala Val Gly Val Gln Ser Leu Ile 
        275                 280                 285             

Leu Pro Asp Tyr Phe Asp Leu Leu Pro Ala Arg Pro Arg Phe Glu Thr 
    290                 295                 300                 

Phe Gly Asp Val Pro Leu Ile Asp Thr Arg His Val Pro Leu Asp Asp 
305                 310                 315                 320 

Ala Val Asn Ala Phe Leu Lys Arg Ala Phe Asp Ile Val Phe Ser Leu 
                325                 330                 335     

Gly Val Leu Ile Gly Leu Ser Pro Leu Leu Val Ala Ile Ala Ile Ala 
            340                 345                 350         

Val Lys Leu Ser Ser Pro Gly Pro Val Leu Tyr Val Gln Glu Arg Val 
        355                 360                 365             

Gly Lys Asn Arg Arg Thr Phe Lys Met Tyr Lys Phe Arg Thr Met Tyr 
    370                 375                 380                 

Trp Asp Pro Gly Ala Asp Arg Ala Glu Arg Asp Cys Ala Glu Glu Ala 
385                 390                 395                 400 

Asp Leu Arg Ser Ala Gly Trp Thr Val Lys Gly Asp Pro Arg Arg Thr 
                405                 410                 415     

Arg Val Gly Ala Phe Leu Arg Arg Thr Ser Leu Asp Glu Leu Pro Gln 
            420                 425                 430         

Phe Trp Asn Val Leu Lys Gly Asp Met Ser Val Ile Gly Pro Arg Pro 
        435                 440                 445             

Glu Arg Pro Val Phe Val Glu Arg Phe Arg Glu Glu Val Pro Arg Tyr 
    450                 455                 460                 

Met Val Lys His Arg Val Arg Pro Gly Ile Thr Gly Trp Ala Gln Val 
465                 470                 475                 480 

His Gly Trp Arg Gly Asp Thr Ser Ile Ala Glu Arg Ile Arg Phe Asp 
                485                 490                 495     

Ile Glu Tyr Ile Glu Asn Trp Ser Phe Trp Leu Asp Leu Lys Ile Val 
            500                 505                 510         

Trp Lys Thr Ile Lys His Gly Phe Val Asn Glu Asn Ala Tyr 
        515                 520                 525     

<210>   96
<211>   526
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 86

<400>   96
Met Asp Pro Asn Gly Arg Phe Ala Ser Trp Gly Arg Thr Pro Ile Asp 
                5                   10                  15      

Val Arg Val Val Ser Lys His Val Glu Ile Gly Phe Pro Arg Leu Pro 
            20                  25                  30          

Met Met Arg Tyr Thr Phe Leu Gly Ser Ser Arg Arg Ile Ala Gly Gly 
        35                  40                  45              

Pro Met Phe Arg Thr Tyr Gln Glu Leu Phe Arg Arg Ile Phe Ile Ala 
    50                  55                  60                  

Thr Asp Ala Ala Ile Val Val Val Ser Phe Leu Ile Ala Trp Trp Leu 
65                  70                  75                  80  

Lys Phe Asp Ser Gly Trp Ile Pro His Ala Gly His Leu Pro Leu Leu 
                85                  90                  95      

Tyr Tyr Arg Gly Pro Leu Leu Ile Ala Val Ile Val Phe Val Leu Ala 
            100                 105                 110         

Asn Gly Val Ala Arg Leu Tyr Glu Pro Met Arg Ala Lys Ser Leu Phe 
        115                 120                 125             

Tyr Glu Ala Tyr Ser Val Ala Lys Gly Val Ile Leu Gly Thr Ile Val 
    130                 135                 140                 

Leu Met Ala Ala Leu Tyr Phe Ala Lys Met Gln Glu Phe Ser Arg Asp 
145                 150                 155                 160 

Val Ile Ala Leu Phe Thr Gly Ile Asn Phe Gly Leu Met Val Gly Glu 
                165                 170                 175     

Arg Ile Val Val Arg Ser Val Leu Arg Ser Leu Arg Arg Arg Gly Leu 
            180                 185                 190         

Asn Gln Arg Phe Leu Leu Ile Val Gly Trp Ser Ala Ala Thr Arg Arg 
        195                 200                 205             

Phe Leu Glu Ala Leu Glu Ala Gln Pro Trp Phe Gly Tyr Arg Val Ile 
    210                 215                 220                 

Gly Tyr Leu Arg Tyr Glu Gly Asp Asp Ala Ser Arg Ala Thr Val Pro 
225                 230                 235                 240 

Cys Ile Gly Ala Val Asp Asp Ile Arg Cys Val Leu Glu Glu His Leu 
                245                 250                 255     

Val Asp Gln Val Val Ile Ala Ala Pro Arg Asp Arg Val Gly Asp Leu 
            260                 265                 270         

Ala Glu Val Ile Ser Ala Cys Glu Ala Val Gly Val Gln Ser Leu Ile 
        275                 280                 285             

Leu Pro Asp Tyr Phe Asp Leu Leu Pro Ala Arg Pro Arg Phe Glu Thr 
    290                 295                 300                 

Phe Gly Asp Val Pro Leu Ile Asp Thr Arg His Val Pro Leu Asp Asp 
305                 310                 315                 320 

Ala Val Asn Ala Phe Leu Lys Arg Ala Phe Asp Ile Val Phe Ser Leu 
                325                 330                 335     

Gly Val Leu Ile Gly Leu Ser Pro Leu Leu Val Ala Ile Ala Ile Ala 
            340                 345                 350         

Val Lys Leu Ser Ser Pro Gly Pro Val Leu Tyr Val Gln Glu Arg Val 
        355                 360                 365             

Gly Lys Asn Arg Arg Thr Phe Lys Met Tyr Lys Phe Arg Thr Met Tyr 
    370                 375                 380                 

Trp Asp Pro Gly Ala Asp Arg Ala Glu Arg Asp Cys Ala Glu Glu Ala 
385                 390                 395                 400 

Asp Leu Arg Ser Ala Gly Trp Thr Val Lys Gly Asp Pro Arg Arg Thr 
                405                 410                 415     

Arg Val Gly Ala Phe Leu Arg Arg Thr Ser Leu Asp Glu Leu Pro Gln 
            420                 425                 430         

Phe Trp Asn Val Leu Lys Gly Asp Met Ser Val Ile Gly Pro Arg Pro 
        435                 440                 445             

Glu Arg Pro Val Phe Val Glu Arg Phe Arg Glu Glu Val Pro Arg Tyr 
    450                 455                 460                 

Met Val Lys His Arg Val Arg Pro Gly Ile Thr Gly Trp Ala Gln Val 
465                 470                 475                 480 

His Gly Trp Arg Gly Asp Thr Ser Ile Ala Glu Arg Ile Arg Phe Asp 
                485                 490                 495     

Ile Glu Tyr Ile Glu Asn Trp Ser Phe Trp Leu Asp Leu Lys Ile Val 
            500                 505                 510         

Trp Lys Thr Ile Lys His Gly Phe Val Asn Glu Asn Ala Tyr 
        515                 520                 525     

<210>   97
<211>   526
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 86

<400>   97
Met Asp Pro Asn Gly Arg Phe Ala Ser Trp Gly Arg Thr Pro Ile Asp 
                5                   10                  15      

Val Arg Val Val Ser Lys His Val Glu Ile Gly Phe Pro Arg Leu Pro 
            20                  25                  30          

Met Met Arg Tyr Thr Phe Leu Gly Ser Ser Arg Arg Ile Ala Gly Gly 
        35                  40                  45              

Pro Met Phe Arg Thr Tyr Gln Glu Leu Phe Arg Arg Ile Phe Ile Ala 
    50                  55                  60                  

Thr Asp Ala Ala Ile Val Val Val Ser Phe Leu Leu Ala Trp Trp Leu 
65                  70                  75                  80  

Lys Phe Asp Ser Gly Trp Ile Pro His Ala Gly His Leu Pro Leu Leu 
                85                  90                  95      

Tyr Tyr Arg Gly Pro Leu Leu Ile Ala Val Ile Val Phe Val Leu Ala 
            100                 105                 110         

Asn Gly Val Ala Arg Leu Tyr Glu Pro Met Arg Ala Lys Ser Leu Phe 
        115                 120                 125             

Tyr Glu Ala Tyr Ser Val Ala Lys Gly Val Ile Leu Gly Thr Ile Val 
    130                 135                 140                 

Leu Met Ala Ala Leu Tyr Phe Ala Lys Met Gln Glu Phe Ser Arg Asp 
145                 150                 155                 160 

Val Ile Ala Leu Phe Thr Gly Ile Asn Phe Gly Leu Met Val Gly Glu 
                165                 170                 175     

Arg Ile Val Val Arg Ser Val Leu Arg Ser Leu Arg Arg Arg Gly Leu 
            180                 185                 190         

Asn Gln Arg Phe Leu Leu Ile Val Gly Trp Ser Ala Ala Thr Arg Arg 
        195                 200                 205             

Phe Leu Glu Ala Leu Glu Ala Gln Pro Trp Phe Gly Tyr Arg Val Ile 
    210                 215                 220                 

Gly Tyr Leu Arg Tyr Glu Gly Asp Asp Ala Ser Arg Ala Thr Val Pro 
225                 230                 235                 240 

Cys Ile Gly Ala Val Asp Asp Ile Arg Cys Val Leu Glu Glu His Leu 
                245                 250                 255     

Val Asp Gln Val Val Ile Ala Ala Pro Arg Asp Arg Val Gly Asp Leu 
            260                 265                 270         

Ala Glu Val Ile Ser Ala Cys Glu Ala Val Gly Val Gln Ser Leu Ile 
        275                 280                 285             

Leu Pro Asp Tyr Phe Asp Leu Leu Pro Ala Arg Pro Arg Phe Glu Thr 
    290                 295                 300                 

Phe Gly Asp Val Pro Leu Ile Asp Thr Arg His Val Pro Leu Asp Asp 
305                 310                 315                 320 

Ala Val Asn Ala Phe Leu Lys Arg Ala Phe Asp Ile Val Phe Ser Leu 
                325                 330                 335     

Gly Val Leu Ile Gly Leu Ser Pro Leu Leu Val Ala Ile Ala Ile Ala 
            340                 345                 350         

Val Lys Leu Ser Ser Pro Gly Pro Val Leu Tyr Val Gln Glu Arg Val 
        355                 360                 365             

Gly Lys Asn Arg Arg Thr Phe Lys Met Tyr Lys Phe Arg Thr Met Tyr 
    370                 375                 380                 

Trp Asp Pro Gly Ala Asp Arg Ala Glu Arg Asp Cys Ala Glu Glu Ala 
385                 390                 395                 400 

Asp Leu Lys Ser Ala Gly Trp Thr Val Lys Gly Asp Pro Arg Arg Thr 
                405                 410                 415     

Arg Val Gly Ala Phe Leu Arg Arg Thr Ser Leu Asp Glu Leu Pro Gln 
            420                 425                 430         

Phe Trp Asn Val Leu Lys Gly Asp Met Ser Val Ile Gly Pro Arg Pro 
        435                 440                 445             

Glu Arg Pro Val Phe Val Glu Arg Phe Arg Glu Glu Val Pro Arg Tyr 
    450                 455                 460                 

Met Val Lys His Arg Val Arg Pro Gly Ile Thr Gly Trp Ala Gln Val 
465                 470                 475                 480 

His Gly Trp Arg Gly Asp Thr Ser Ile Ala Glu Arg Ile Arg Phe Asp 
                485                 490                 495     

Ile Glu Tyr Ile Glu Asn Trp Ser Phe Trp Leu Asp Leu Lys Ile Val 
            500                 505                 510         

Trp Lys Thr Ile Lys His Gly Phe Val Asn Glu Asn Ala Tyr 
        515                 520                 525     

<210>   98
<211>   1581
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 87

<400>   98
atggacccga acggtaggtt tgcaagttgg ggaagaacgc ccatcgacgt aagggtggtg       60

tcaaaacatg tcgaaatagg cttccctcgc ttgccaatga tgcgctatac tttccttggt      120

agttcacgcc gcatcgcggg tggtcctatg tttcgcactt atcaggagct gttccggcga      180

atcttcatcg ctaccgacgc ggccatcgtc gtcgtgagtt ttctactcgc atggtggctc      240

aagtttgatt ctgggtggat tccgcacgcc ggccatctcc cactcctcta ttatcgaggg      300

ccgcttctca tcgccgtgat cgtattcgtg cttgcaaacg gtgtagcgcg gctctacgaa      360

ccgatgcgcg cgaagagctt gttctacgag gcgtacagcg tagcgaaggg cgtcatcctc      420

gggacaattg tcctcatggc tgccctctat ttcgcgaaga tgcaggagtt ttcgcgagac      480

gtcatcgcgc tctttactgg catcaacttc gggctcatgg tgggagagcg gatcgtcgtg      540

cgctccgtgc tgcgcagcct gcgccgccga gggttgaatc agcgatttct cctcatcgtg      600

ggctggagtg cagcgacgcg tcgcttcctc gaggccctgg aggcccagcc gtggttcggt      660

taccgtgtca taggctatct ccgttacgaa ggtgatgatg cgtcgcgcgc gacagtgcca      720

tgcatcgggg cggttgacga cattaaatgc gtgcttgagg agcacctcgt cgatcaggtg      780

gtcatcgcgg caccgcggga tcgagtgggc gatctcgccg aagtgatttc cgcctgcgaa      840

gctgtagggg tccagtcgct gatcttgccg gattacttcg atctcctgcc ggccaggccc      900

cgttttgaaa cctttggaga tgtgccgctg attgacacgc gccatgtgcc gctggacgat      960

gcggtgaacg ccttcctgaa gcgcgcgttc gacatcgtgt tcagtctggg ggtcctgatt     1020

ggtctgtcgc cgctgttggt ggccattgcg attgcggtga agctttcgtc gccagggcca     1080

gtgctgtacg tgcaggagcg agtgggcaaa aatcgacgga catttaagat gtacaagttc     1140

cgaacgatgt actgggatcc cggggcggac cgtgcggagc gggattgcgc ggaagaggcg     1200

gacctgcgga gcgctggttg gacggtgaaa ggcgatccgc ggcggactcg cgtgggagcg     1260

ttcctacgtc gcacgagttt ggacgagctc cctcagttct ggaacgtgct gaagggagac     1320

atgagcgtca ttgggccgcg cccggagcgc cccgtcttcg tcgagcgatt ccgagaagag     1380

gtgccgcgtt acatggtcaa gcaccgcgtg agaccaggta tcaccgggtg ggcgcaggtg     1440

catggatggc gcggagatac ttcgattgct gaacggattc gatttgacat tgagtacatc     1500

gaaaactggt cattctggct tgatctcaag attgtgtgga agactatcaa acatgggttt     1560

gtgaatgaga atgcgtattg a                                               1581


<210>   99
<211>   1581
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 87

<400>   99
atggacccga acggtaggtt tgcaagttgg ggaagaacgc ccatcgacgt aagggtggtg       60

tcaaaacatg tcgaattagg cttccctcgc ttgccaatga tgcgctatac tttccttggt      120

agttcacgcc gcatcgcggg tggtcctatg tttcgcactt atcaggagct gttccggcga      180

atcttcatcg ctaccgacgc ggccatcgtc gtcgtgagtt ttctactcgc atggtggctc      240

aagtttgatt ctgggtggat tccgcacgcc ggccatctcc cactcctcta ttatcgaggg      300

ccgcttctca tcgccgtgat cgtattcgtg cttgcaaacg gtgtagcgcg gctctacgaa      360

ccgatgcgcg cgaagagctt gttctacgag gcgtacagcg tagcgaaggg cgtcatcctc      420

gggacaattg tcctcatggc tgccctctat ttcgcgaaga tgcaggagtt ttcgcgagac      480

gtcatcgcgc tctttactgg catcaacttc gggctcatgg tgggagagcg gatcgtcgtg      540

cgctccgtgc tgcgcagcct gcgccgccga gggttgaatc agcgatttct cctcatcgtg      600

ggctggagtg cagcgacgcg tcgcttcctc gaggccctgg aggcccagcc gtggttcggt      660

taccgtgtca taggctatct ccgttacgaa ggtgatgatg cgtcgcgcgc gacagtgcca      720

tgcatcgggg cggttgacga cattcgttgc gtgcttgagg agcacctcgt cgatcaggtg      780

gtcatcgcgg caccgcggga tcgagtgggc gatctcgccg aagtgatttc cgcctgcgaa      840

gctgtagggg tccagtcgct gatcttgccg gattacttcg atctcctgcc ggccaggccc      900

cgttttgaaa cctttggaga tgtgccgctg attgacacgc gccatgtgcc gctggacgat      960

gcggtgaacg ccttcctgaa gcgcgcgttc gacatcgtgt tcagtctggg ggtcctgatt     1020

ggtctgtcgc cgctgttggt ggccattgcg attgcggtga agctttcgtc gccagggcca     1080

gtgctgtacg tgcaggagcg agtgggcaaa aatcgacgga catttaagat gtacaagttc     1140

cgaacgatgt actgggatcc cggggcggac cgtgcggagc gggattgcgc ggaagaggcg     1200

gacctgcgga gcgctggttg gacggtgaaa ggcgatccgc ggcggactcg cgtgggagcg     1260

ttcctacgtc gcacgagttt ggacgagctc cctcagttct ggaacgtgct gaagggagac     1320

atgagcgtca ttgggccgcg cccggagcgc cccgtcttcg tcgagcgatt ccgagaagag     1380

gtgccgcgtt acatggtcaa gcaccgcgtg agaccaggta tcaccgggtg ggcgcaggtg     1440

catggatggc gcggagatac ttcgattgct gaacggattc gatttgacat tgagtacatc     1500

gaaaactggt cattctggct tgatctcaag attgtgtgga agactatcaa acatgggttt     1560

gtgaatgaga atgcgtattg a                                               1581


<210>   100
<211>   1581
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 87

<400>   100
atggacccga acggtaggtt tgcaagttgg ggaagaacgc ccatcgacgt aagggtggtg       60

tcaaaacatg tcgaaatagg cttccctcgc ttgccaatga tgcgctatac tttccttggt      120

agttcacgcc gcatcgcggg tggtcctatg tttcgcactt atcaggagct gttccggcga      180

atcttcatcg ctaccgacgc ggccatcgtc gtcgtgagtt ttctactcgc atggtggctc      240

aagtttgatt ctgggtggat tccgcacgcc ggccatctcc cactcctcta ttatcgaggg      300

ccgcttctca tcgccgtgat cgtattcgtg cttgcaaacg gtgtagcgcg gctctacgaa      360

ccgatgcgcg cgaagagctt gttctacgag gcgtacagcg tagcgaaggg cgtcatcctc      420

gggacaattg tcctcatggc tgccctctat ttcgcgaaga tgcaggagtt ttcgcgagac      480

gtcatcgcgc tctttactgg catcaacttc gggctcatgg tgggagagcg gatcgtcgtg      540

cgctccgtgc tgcgcagcct gcgccgccga gggttgaatc agcgatttct cctcatcgtg      600

ggctggagtg cagcgacgcg tcgcttcctc gaggccctgg aggcccagcc gtggttcggt      660

taccgtgtca taggctatct ccgttacgaa ggtgatgatg cgtcgcgcgc gacagtgcca      720

tgcatcgggg cggttgaaga cattcgttgc gtgcttgagg agcacctcgt cgatcaggtg      780

gtcatcgcgg caccgcggga tcgagtgggc gatctcgccg aagtgatttc cgcctgcgaa      840

gctgtagggg tccagtcgct gatcttgccg gattacttcg atctcctgcc ggccaggccc      900

cgttttgaaa cctttggaga tgtgccgctg attgacacgc gccatgtgcc gctggacgat      960

gcggtgaacg ccttcctgaa gcgcgcgttc gacatcgtgt tcagtctggg ggtcctgatt     1020

ggtctgtcgc cgctgttggt ggccattgcg attgcggtga agctttcgtc gccagggcca     1080

gtgctgtacg tgcaggagcg agtgggcaaa aatcgacgga catttaagat gtacaagttc     1140

cgaacgatgt actgggatcc cggggcggac cgtgcggagc gggattgcgc ggaagaggcg     1200

gacctgcgga gcgctggttg gacggtgaaa ggcgatccgc ggcggactcg cgtgggagcg     1260

ttcctacgtc gcacgagttt ggacgagctc cctcagttct ggaacgtgct gaagggagac     1320

atgagcgtca ttgggccgcg cccggagcgc cccgtcttcg tcgagcgatt ccgagaagag     1380

gtgccgcgtt acatggtcaa gcaccgcgtg agaccaggta tcaccgggtg ggcgcaggtg     1440

catggatggc gcggagatac ttcgattgct gaacggattc gatttgacat tgagtacatc     1500

gaaaactggt cattctggct tgatctcaag attgtgtgga agactatcaa acatgggttt     1560

gtgaatgaga atgcgtattg a                                               1581


<210>   101
<211>   1581
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 87

<400>   101
atggacccga acggtaggtt tgcaagttgg ggaagaacgc ccatcgacgt aagggtggtg       60

tcaaaacatg tcgaaatagg cttccctcgc ttgccaatga tgcgctatac tttccttggt      120

agttcacgcc gcatcgcggg tggtcctatg tttcgcactt atcaggagct gttccggcga      180

atcttcatcg ctaccgacgc ggccatcgtc gtcgtgagtt ttctaattgc atggtggctc      240

aagtttgatt ctgggtggat tccgcacgcc ggccatctcc cactcctcta ttatcgaggg      300

ccgcttctca tcgccgtgat cgtattcgtg cttgcaaacg gtgtagcgcg gctctacgaa      360

ccgatgcgcg cgaagagctt gttctacgag gcgtacagcg tagcgaaggg cgtcatcctc      420

gggacaattg tcctcatggc tgccctctat ttcgcgaaga tgcaggagtt ttcgcgagac      480

gtcatcgcgc tctttactgg catcaacttc gggctcatgg tgggagagcg gatcgtcgtg      540

cgctccgtgc tgcgcagcct gcgccgccga gggttgaatc agcgatttct cctcatcgtg      600

ggctggagtg cagcgacgcg tcgcttcctc gaggccctgg aggcccagcc gtggttcggt      660

taccgtgtca taggctatct ccgttacgaa ggtgatgatg cgtcgcgcgc gacagtgcca      720

tgcatcgggg cggttgacga cattcgttgc gtgcttgagg agcacctcgt cgatcaggtg      780

gtcatcgcgg caccgcggga tcgagtgggc gatctcgccg aagtgatttc cgcctgcgaa      840

gctgtagggg tccagtcgct gatcttgccg gattacttcg atctcctgcc ggccaggccc      900

cgttttgaaa cctttggaga tgtgccgctg attgacacgc gccatgtgcc gctggacgat      960

gcggtgaacg ccttcctgaa gcgcgcgttc gacatcgtgt tcagtctggg ggtcctgatt     1020

ggtctgtcgc cgctgttggt ggccattgcg attgcggtga agctttcgtc gccagggcca     1080

gtgctgtacg tgcaggagcg agtgggcaaa aatcgacgga catttaagat gtacaagttc     1140

cgaacgatgt actgggatcc cggggcggac cgtgcggagc gggattgcgc ggaagaggcg     1200

gacctgcgga gcgctggttg gacggtgaaa ggcgatccgc ggcggactcg cgtgggagcg     1260

ttcctacgtc gcacgagttt ggacgagctc cctcagttct ggaacgtgct gaagggagac     1320

atgagcgtca ttgggccgcg cccggagcgc cccgtcttcg tcgagcgatt ccgagaagag     1380

gtgccgcgtt acatggtcaa gcaccgcgtg agaccaggta tcaccgggtg ggcgcaggtg     1440

catggatggc gcggagatac ttcgattgct gaacggattc gatttgacat tgagtacatc     1500

gaaaactggt cattctggct tgatctcaag attgtgtgga agactatcaa acatgggttt     1560

gtgaatgaga atgcgtattg a                                               1581


<210>   102
<211>   1581
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 87

<400>   102
atggacccga acggtaggtt tgcaagttgg ggaagaacgc ccatcgacgt aagggtggtg       60

tcaaaacatg tcgaaatagg cttccctcgc ttgccaatga tgcgctatac tttccttggt      120

agttcacgcc gcatcgcggg tggtcctatg tttcgcactt atcaggagct gttccggcga      180

atcttcatcg ctaccgacgc ggccatcgtc gtcgtgagtt ttctactcgc atggtggctc      240

aagtttgatt ctgggtggat tccgcacgcc ggccatctcc cactcctcta ttatcgaggg      300

ccgcttctca tcgccgtgat cgtattcgtg cttgcaaacg gtgtagcgcg gctctacgaa      360

ccgatgcgcg cgaagagctt gttctacgag gcgtacagcg tagcgaaggg cgtcatcctc      420

gggacaattg tcctcatggc tgccctctat ttcgcgaaga tgcaggagtt ttcgcgagac      480

gtcatcgcgc tctttactgg catcaacttc gggctcatgg tgggagagcg gatcgtcgtg      540

cgctccgtgc tgcgcagcct gcgccgccga gggttgaatc agcgatttct cctcatcgtg      600

ggctggagtg cagcgacgcg tcgcttcctc gaggccctgg aggcccagcc gtggttcggt      660

taccgtgtca taggctatct ccgttacgaa ggtgatgatg cgtcgcgcgc gacagtgcca      720

tgcatcgggg cggttgacga cattcgttgc gtgcttgagg agcacctcgt cgatcaggtg      780

gtcatcgcgg caccgcggga tcgagtgggc gatctcgccg aagtgatttc cgcctgcgaa      840

gctgtagggg tccagtcgct gatcttgccg gattacttcg atctcctgcc ggccaggccc      900

cgttttgaaa cctttggaga tgtgccgctg attgacacgc gccatgtgcc gctggacgat      960

gcggtgaacg ccttcctgaa gcgcgcgttc gacatcgtgt tcagtctggg ggtcctgatt     1020

ggtctgtcgc cgctgttggt ggccattgcg attgcggtga agctttcgtc gccagggcca     1080

gtgctgtacg tgcaggagcg agtgggcaaa aatcgacgga catttaagat gtacaagttc     1140

cgaacgatgt actgggatcc cggggcggac cgtgcggagc gggattgcgc ggaagaggcg     1200

gacctgaaaa gcgctggttg gacggtgaaa ggcgatccgc ggcggactcg cgtgggagcg     1260

ttcctacgtc gcacgagttt ggacgagctc cctcagttct ggaacgtgct gaagggagac     1320

atgagcgtca ttgggccgcg cccggagcgc cccgtcttcg tcgagcgatt ccgagaagag     1380

gtgccgcgtt acatggtcaa gcaccgcgtg agaccaggta tcaccgggtg ggcgcaggtg     1440

catggatggc gcggagatac ttcgattgct gaacggattc gatttgacat tgagtacatc     1500

gaaaactggt cattctggct tgatctcaag attgtgtgga agactatcaa acatgggttt     1560

gtgaatgaga atgcgtattg a                                               1581


<210>   103
<211>   385
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   103
Met Arg Met Arg Ile Glu Ser Thr Gly Ser Arg Leu Asn Arg Thr Val 
                5                   10                  15      

Arg Ile Gly Val Asp Cys Arg Pro Leu Val Gly Asp Lys Thr Gly Ile 
            20                  25                  30          

Gly Tyr Tyr Leu Trp Glu Ile Leu Asp Glu Trp Ala Arg Ala Glu Ile 
        35                  40                  45              

Asp Phe Val Glu Leu Tyr Leu Tyr Ala Ser Lys Pro Phe Glu Leu Pro 
    50                  55                  60                  

Ser Ala Phe Ala Asn Thr Arg Leu Leu Tyr Arg Lys Arg Val Arg Arg 
65                  70                  75                  80  

Leu Ser Pro Gly Glu Leu Trp Ala Gln Thr Ala Leu Pro Val Leu Val 
                85                  90                  95      

Ala Arg Asp Gly Ile Asp Val Phe Trp Gly Pro Asn Phe Cys Leu Pro 
            100                 105                 110         

Leu Leu Cys His Val Pro Thr Val Leu Thr Ile His Asp Met Val Tyr 
        115                 120                 125             

Lys Val Leu Pro Asp Thr Met Met Arg Lys Thr Tyr Tyr His Asn Ala 
    130                 135                 140                 

Phe Gly Leu Pro Leu Tyr Ala Arg Lys Ser Gln Lys Ile Leu Val Pro 
145                 150                 155                 160 

Ser Val Asn Thr Lys Leu Asp Val Val Lys Tyr Leu Arg Val Ala Glu 
                165                 170                 175     

Asp Arg Val Val Val Thr Pro Leu Gly Met Pro Lys Arg Phe Arg Gln 
            180                 185                 190         

Glu Leu Asp Thr Gly Ile Ile Leu Ser His Arg Phe Gly Leu Glu Met 
        195                 200                 205             

Gly Ser Tyr Ile Leu Ala Val Gly Thr Val Glu Pro Arg Lys Asn Leu 
    210                 215                 220                 

Glu Arg Val Val Arg Ala Phe Arg Leu Ala Arg Lys Ala His Pro Asp 
225                 230                 235                 240 

Met Lys Leu Val Val Ala Gly Thr Leu Gly Trp Ala Ser Glu Gln Thr 
                245                 250                 255     

Gln Ser Ala Leu Gln Asp Glu Gly Val Ile Tyr Val Gly Tyr Val Ser 
            260                 265                 270         

Asp Val Glu Leu Met Ala Leu Tyr Lys Gly Cys Arg Phe Phe Val Tyr 
        275                 280                 285             

Val Pro Leu Tyr Glu Gly Phe Gly Met Pro Pro Leu Glu Ala Met Ala 
    290                 295                 300                 

Val Gly Lys Pro Val Leu Thr Ala Asn Asn Ser Ser Leu Pro Glu Val 
305                 310                 315                 320 

Val Gly Arg Ala Ala Ile Leu Val Asp Ala Thr Arg Glu Glu Cys Ile 
                325                 330                 335     

Arg Glu Gly Met Ser Leu Leu Trp Val Asp Gly Asp Leu Arg Glu Arg 
            340                 345                 350         

Leu Ser Glu Gln Ala Leu Ala Arg Ala Arg Lys Phe Ser Trp Asp Glu 
        355                 360                 365             

Thr Ala Gln Lys Thr Leu Asn Val Ile Leu Asn Val Val Gly Ala Gln 
    370                 375                 380                 

Thr 
385 

<210>   104
<211>   1158
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   104
atgagaatgc gtattgagag cactggaagt cgtttgaacc gcacggtgcg aattggcgtg       60

gactgcaggc cgcttgtcgg agataagacc gggattggtt attatttgtg ggaaattctc      120

gacgaatggg ctcgagccga gattgatttc gtcgagcttt atctgtacgc atccaagccc      180

tttgaactcc cgagtgcgtt tgcgaacacc agactcctat atcggaagcg tgtgcgtcgg      240

ctttcgccag gagaattatg ggcgcagact gcacttcctg tacttgtggc ccgtgatggc      300

attgatgtgt tttgggggcc gaatttttgt ttgcctcttt tgtgccatgt accgactgta      360

cttacgattc acgatatggt gtacaaagtg ctacccgata cgatgatgag aaagacgtat      420

tatcacaatg cgttcgggct gcctctttac gcgcgaaaat cacagaagat cctagtgcca      480

tctgtcaaca caaaattgga tgtcgtcaaa tatcttcgag tcgccgaaga tcgtgtggtt      540

gtcacgccgc taggcatgcc gaagcgcttc cggcaggaat tagatacggg aataattctt      600

tcgcataggt tcggacttga gatgggatcg tacattttgg ccgtgggtac cgtggaacca      660

agaaaaaatt tggagcgtgt tgttcgggcg tttcgattgg ctcgaaaagc tcatccagat      720

atgaagttgg ttgtggctgg tacattgggg tgggcttcgg agcaaacgca atcggctttg      780

caagatgagg gagtcatcta tgttggctac gtgtctgatg ttgagctgat ggcattatac      840

aaagggtgta ggttttttgt gtatgtaccg ttatacgagg gttttggcat gccgccactt      900

gaggccatgg cggttggtaa gccggtatta acggcaaaca acagttctct cccagaagtt      960

gttgggcggg ccgcgatctt ggtggacgcc acgcgtgagg agtgtataag ggagggaatg     1020

tccttgcttt gggttgatgg tgacttaagg gagcgcttgt ctgagcaagc gttggcccgg     1080

gctcgaaagt tctcatggga tgaaactgct cagaaaacgc tcaacgtcat cttgaacgtg     1140

gttggtgccc agacgtga                                                   1158


<210>   105
<211>   357
<212>   PRT
<213>   Chloroflexus aggregans DSM 9485

<400>   105
Arg Ala Gly Val Ser His Tyr Ile Glu Gln Val Leu Leu His Leu Ala 
                5                   10                  15      

Gln Ile Asp His Glu Asn Arg Tyr Thr Ile Tyr Thr Thr Arg Gly Leu 
            20                  25                  30          

Asp Gln Ala Ala Leu Gly Leu Pro Pro Asn Phe Val Val Lys Pro Ser 
        35                  40                  45              

Arg Leu Pro Thr Ile Asn Pro Arg Ile Arg Ile Pro Trp Glu Gln Gly 
    50                  55                  60                  

Ile Ala Pro Phe Leu Leu Arg Gly Lys Val Asp Leu Tyr His Gly Cys 
65                  70                  75                  80  

Leu Asn Val Ala Pro Leu Leu Ser Pro Val Pro Thr Val Ile Thr Ile 
                85                  90                  95      

His Asp Leu Ala Phe Ile Arg Phe Pro Gln Thr Phe Arg Ala Tyr Asn 
            100                 105                 110         

Arg Ile Tyr Leu Asp Leu Ala Thr Arg Leu Ser Ala Arg Arg Ala Ser 
        115                 120                 125             

Arg Ile Leu Ala Val Ser Glu His Thr Lys Arg Glu Val Ala Gly Leu 
    130                 135                 140                 

Phe Gly Ile Pro Pro Glu Arg Ile Val Val Thr Pro Asn Ala Thr Arg 
145                 150                 155                 160 

Ser His Phe Arg Pro Phe Ala Ala Asp Ile Ile Asp Gln Phe Arg Ala 
                165                 170                 175     

Arg Lys Gly Leu Pro Ala Arg Phe Ile Leu Tyr Val Gly Thr Leu Glu 
            180                 185                 190         

Pro Arg Lys Asn Leu Thr Thr Leu Leu Glu Ala Phe Ala Leu Val Ser 
        195                 200                 205             

Arg Arg Val Pro Ser Val Pro Leu Leu Ile Gly Gly Gly Lys Gly Trp 
    210                 215                 220                 

Met Tyr Gln Pro Ile Phe Ala Arg Leu Glu Gln Leu Asn Leu Gln Asp 
225                 230                 235                 240 

Arg Val Lys Phe Val Gly Tyr Ile Pro Glu Glu Glu Leu Pro Leu Trp 
                245                 250                 255     

Tyr Ala Ala Ala Thr Ile Phe Val Phe Pro Ser Ile Tyr Glu Gly Phe 
            260                 265                 270         

Gly Met Pro Pro Leu Glu Ala Met Ala Cys Gly Thr Pro Val Ile Thr 
        275                 280                 285             

Ser Asn Thr Ser Ser Leu Pro Glu Val Val Gly Asp Ala Gly Leu Met 
    290                 295                 300                 

Val Asp Pro Ala Ala Pro Thr Ala Leu Ala Asp Ala Met Met Gln Leu 
305                 310                 315                 320 

Leu Thr Asp Ala Asp Leu His Ala Ala Leu Arg Gln Arg Gly Leu Glu 
                325                 330                 335     

Arg Ala Arg Arg Phe Ser Trp Thr Glu Thr Ala Ala Lys Thr Leu Ala 
            340                 345                 350         

Val Tyr Arg Glu Val 
        355         

<210>   106
<211>   354
<212>   PRT
<213>   Roseiflexus sp. RS-1

<400>   106
Arg Thr Gly Thr Glu Gln Tyr Thr Cys Glu Val Leu Ala Ala Ile Ala 
                5                   10                  15      

Arg Leu Asp Thr Thr Asn Thr Tyr Thr Leu Tyr Cys Gln Arg Leu Pro 
            20                  25                  30          

Thr Thr Leu Pro Pro Leu Gly Ala Asn Met Arg Met Arg Cys Ile Pro 
        35                  40                  45              

Leu Pro Arg Leu Trp Thr His Val Arg Leu Ser Val Glu Val Leu Arg 
    50                  55                  60                  

His Ala Pro Asp Val Leu Phe Ile Pro Ala His Val Leu Pro Leu Gly 
65                  70                  75                  80  

Ala Pro Leu Val Arg Arg Met Arg Thr Val Val Thr Ile His Asp Leu 
                85                  90                  95      

Gly Tyr Leu Arg Tyr Pro Glu Ala His Thr Thr Ala Gln Arg Leu Tyr 
            100                 105                 110         

Leu Arg Leu Ser Thr Val Trp Ser Ala Arg Ala Ala Ser His Leu Ile 
        115                 120                 125             

Ala Val Ser Glu Ala Thr Arg Asn Asp Leu Val Arg Leu Ala Lys Val 
    130                 135                 140                 

Ser Pro Ala Arg Val Thr Val Val His His Gly Val Ala Asp Arg Phe 
145                 150                 155                 160 

Arg Gln Pro Val Val Asp Leu Gly Arg Ala Arg Lys Ile Ala Gly Gly 
                165                 170                 175     

Asn Glu Pro Tyr Phe Leu Tyr Val Gly Thr Val Gln Pro Arg Lys Asn 
            180                 185                 190         

Leu Glu Arg Val Ile Glu Ala Phe Ala Asp Ala Ser Ala Gln Leu Thr 
        195                 200                 205             

Asp Gln Gly Arg Thr Pro Val Leu Val Ile Ala Gly Lys Arg Gly Trp 
    210                 215                 220                 

Leu Ser Glu Arg Ile Ala Gln Arg Ala Ala Ala Leu Gly Ile Ala Asp 
225                 230                 235                 240 

Arg Val Arg Phe Val Gly Tyr Val Ala Asp Glu Asp Leu Pro Ala Leu 
                245                 250                 255     

Tyr Arg Ala Ser Leu Ala Phe Val Phe Pro Ser Leu Tyr Glu Gly Phe 
            260                 265                 270         

Gly Met Pro Val Leu Glu Ala Met Ala Cys Gly Ala Pro Val Leu Thr 
        275                 280                 285             

Ser Asn Ser Ser Ser Leu Pro Glu Val Ala Gly Asp Ala Ala Leu Leu 
    290                 295                 300                 

Val Asp Pro His Asp Thr Gly Ala Ile Ala Ala Gly Met Val Arg Leu 
305                 310                 315                 320 

Ala Arg Asp Glu Ala Leu Arg Glu Glu Leu Gln Gln His Gly Tyr Arg 
                325                 330                 335     

Arg Ala Ala Gln Phe Thr Trp Asp Arg Cys Ala Glu Glu Thr Leu Arg 
            340                 345                 350         

Val Leu 
        

<210>   107
<211>   360
<212>   PRT
<213>   Rhizobium leguminosarum bv. trifolii WSM1325

<400>   107
Met Arg Ile Ser Ile Asp Ala Thr Gly Leu Gly Gly Pro Lys Thr Gly 
                5                   10                  15      

Thr Ser Val Tyr Leu Ile Glu Ile Leu Ser Arg Trp Ser Arg Asn Thr 
            20                  25                  30          

Ser Ile Asn His Glu Phe Thr Ile Phe Ala Ser Glu Lys Ala Val Ser 
        35                  40                  45              

Leu Cys Ser Glu Ala Gly Leu Asp His Arg Phe Arg Phe Val Arg Ala 
    50                  55                  60                  

Pro Asn Asn Arg His Ile Arg Val Ile Trp Gln Gln Leu Met Ile Pro 
65                  70                  75                  80  

Trp His Met Arg Arg Leu Gly Ile Asp Val His Trp Gly Thr Ala Phe 
                85                  90                  95      

Val Leu Pro Val Ala Ser Gln Arg Pro Met Ala Val Thr Ile His Asp 
            100                 105                 110         

Leu Thr Phe Gln Leu Phe Pro Glu Val His Glu Arg Leu Lys Arg Phe 
        115                 120                 125             

Tyr Phe Pro Ala Ile Met Gln Arg Ser Val Ala Lys Ala Gln Ala Val 
    130                 135                 140                 

Phe Ala Val Ser Arg Thr Thr Glu Thr Asp Leu Lys Arg Ile Ile Pro 
145                 150                 155                 160 

Glu Ser Arg Gly Lys Thr Thr Val Thr Leu Leu Ala Ala Arg Lys Leu 
                165                 170                 175     

Gly Ser Asp Ser Gln Ala Pro Arg Asp Gln Arg Asn Ser Gly Asp Tyr 
            180                 185                 190         

Leu Leu Phe Val Gly Thr Leu Glu Pro Arg Lys Asn Leu Pro Arg Leu 
        195                 200                 205             

Leu Ala Ala Trp Gln Met Leu Asp Asp Ala Thr Arg Gly Asn Thr Arg 
    210                 215                 220                 

Leu Val Ile Val Gly Ala Thr Gly Trp Met Val Ser Asp Leu Leu Gln 
225                 230                 235                 240 

Ser Leu Lys Thr Asn Asp Thr Ile Asp Phe Leu Gly His Val Ser Asp 
                245                 250                 255     

Ser Ser Leu Ala Glu Leu Met Gln Gly Ala Arg Ala Leu Leu Tyr Pro 
            260                 265                 270         

Ser Leu Tyr Glu Gly Phe Gly Leu Pro Val Val Glu Ala Met Ala Arg 
        275                 280                 285             

Gly Ile Pro Leu Leu Thr Ser Asn Thr Gly Ala Thr Ala Glu Ile Ala 
    290                 295                 300                 

Glu Gly Ala Ala Ile Leu Val Asp Pro Thr Asn Val Asp Asp Ile Arg 
305                 310                 315                 320 

Gly Gly Leu Val Arg Leu Leu Thr Glu Pro Glu Leu Leu Gly Ala Leu 
                325                 330                 335     

Ser Ala Gln Gly Arg Glu Arg Ala Lys Ser Phe Ser Trp Glu Arg Thr 
            340                 345                 350         

Ala Gln Leu Thr Leu Glu Thr Leu 
        355                 360 

<210>   108
<211>   356
<212>   PRT
<213>   Chloroflexus aurantiacus J-10-fl

<400>   108
Arg Val Thr Val Ala Gln Arg Thr Gly Thr Glu Arg Tyr Ser Tyr Glu 
                5                   10                  15      

Leu Ile Ala Ala Leu Asp Arg Ile Ala Pro Ser Asp Ile His Phe Arg 
            20                  25                  30          

Leu Tyr Val Asn Gly Arg Arg Asp Gln Leu Pro Pro Val Ser Glu Arg 
        35                  40                  45              

Ala Thr Ile His Asp Ile Arg Leu Pro Arg Leu Trp Thr His Leu Arg 
    50                  55                  60                  

Leu Gly Pro Thr Ser Trp Arg Ala Arg Pro His Val Leu Phe Val Pro 
65                  70                  75                  80  

Ala His Val Val Pro Leu Leu His Pro Pro Thr Val Val Thr Ile His 
                85                  90                  95      

Asp Val Gly Tyr Arg Ala Phe Pro Glu Thr His Thr Ala Arg Arg Arg 
            100                 105                 110         

Leu Glu Leu Glu Leu Thr Thr Arg Trp Ser Leu Arg Ala Ala Arg His 
        115                 120                 125             

Val Ile Thr Ile Ser His Ala Thr Lys Arg Asp Leu Ile Asn Trp Tyr 
    130                 135                 140                 

Gly Ala Asp Pro Asn Arg Ile Thr Val Thr His Leu Gly Cys Ser Ser 
145                 150                 155                 160 

Ile Phe Ala Pro Pro Ala Asp Pro Arg Val Val Ala Ala Val Thr Ala 
                165                 170                 175     

His Tyr Gly Leu Asp Gln Arg Pro Tyr Leu Leu Tyr Ile Gly Thr Val 
            180                 185                 190         

Gln Pro Arg Lys Asn Leu Ser Arg Val Ile Asp Ala Leu Ala Leu Thr 
        195                 200                 205             

Ile Ala Ala Gly Tyr Asp Leu Asp Leu Val Ile Ala Gly Lys Arg Gly 
    210                 215                 220                 

Trp Leu Ser Glu Pro Ile Glu Arg Arg Ala Gly Glu Leu Gly Ile Ala 
225                 230                 235                 240 

Asn Arg Val His Phe Thr Gly Phe Val Ala Asp Ala Asp Leu Pro Ala 
                245                 250                 255     

Leu Leu Ala Gly Ala Leu Ala Phe Val Phe Pro Ser Leu Tyr Glu Gly 
            260                 265                 270         

Phe Gly Met Pro Val Val Glu Ala Met Ala Cys Gly Thr Pro Val Ile 
        275                 280                 285             

Thr Ser Thr Ser Ser Ser Leu Pro Glu Ile Ala Gly Asp Ala Ala Leu 
    290                 295                 300                 

Leu Val Asp Pro Leu Asp Thr Asn Ala Ile Ala Ala Ala Ile Met Arg 
305                 310                 315                 320 

Leu Ser Asp Asp Gln Asp Leu Arg Ala Thr Leu Arg Gln Arg Gly Leu 
                325                 330                 335     

Ala Arg Ala His Leu Phe Asn Trp Glu Thr Cys Ala Arg Gln Thr Leu 
            340                 345                 350         

Ala Val Leu Leu 
        355     

<210>   109
<211>   368
<212>   PRT
<213>   Roseiflexus castenholzii DSM 13941

<400>   109
Met Arg Ile Gly Ile Asp Ile Ser Arg Met Ala Thr Ile Ala Arg Thr 
                5                   10                  15      

Gly Thr Glu His Tyr Thr Gly Glu Val Val Ala Ala Ile Ala Arg Arg 
            20                  25                  30          

Asp Ala Val Asn Thr Tyr Thr Leu Tyr Cys Asn Gln Pro Pro Ala Arg 
        35                  40                  45              

Leu Pro Ser Leu Gly Ala Asn Met Thr Val Arg Cys Ile Pro Leu Pro 
    50                  55                  60                  

Arg Leu Trp Thr His Val Arg Leu Ser Gly Glu Val Leu Arg His Pro 
65                  70                  75                  80  

Pro Asp Val Leu Phe Ile Pro Ala His Val Leu Pro Leu Gly Ala Pro 
                85                  90                  95      

Leu Val Arg Arg Met Arg Thr Val Val Thr Val His Asp Leu Gly Tyr 
            100                 105                 110         

Val Arg Tyr Pro Glu Ala His Thr Ala Ala Gln Arg Leu Tyr Leu Gln 
        115                 120                 125             

Met Ser Thr Ile Trp Ser Ala Arg Ala Ala Ser His Leu Ile Ala Val 
    130                 135                 140                 

Ser Ala Ala Thr Arg Asn Asp Leu Val Arg Leu Ala Gly Val Ser Pro 
145                 150                 155                 160 

Asn Arg Ile Thr Val Val His His Gly Val Ala Glu Arg Phe Arg Arg 
                165                 170                 175     

Ala Leu Ala Asp Ser Ser Arg Thr Arg Ala Ile Thr Gly Gly Asp Glu 
            180                 185                 190         

Pro Tyr Phe Leu Tyr Val Gly Thr Val Gln Pro Arg Lys Asn Leu Ala 
        195                 200                 205             

Arg Val Ile Ala Ala Phe Ala Asp Ala Ser Arg Arg Leu Thr Gly Cys 
    210                 215                 220                 

Gly Met Ala Pro Ile Leu Val Ile Ala Gly Lys Arg Gly Trp Leu Ser 
225                 230                 235                 240 

Glu Gly Ile Ala Arg Arg Ala Ala Glu Val Gly Ile Ala Asp Arg Val 
                245                 250                 255     

Arg Phe Val Gly Tyr Val Ala Asp Asp Asp Leu Pro Ala Leu Tyr His 
            260                 265                 270         

Gly Ala Leu Ala Phe Val Phe Pro Ser Leu Tyr Glu Gly Phe Gly Met 
        275                 280                 285             

Pro Val Leu Glu Ala Met Ala Cys Gly Ala Pro Val Leu Thr Ser Asn 
    290                 295                 300                 

Ser Ser Ser Leu Pro Glu Val Ala Gly Asp Ala Ala Leu Ile Val Asp 
305                 310                 315                 320 

Pro Leu Asp Thr Gly Ala Ile Ala Glu Gly Met Val Arg Leu Val Cys 
                325                 330                 335     

Asp Ala Ala Leu Arg Gln Glu Leu Arg Gln Arg Gly Tyr Arg Arg Ala 
            340                 345                 350         

Ala Gln Phe Thr Trp Asp Arg Cys Ala Glu Glu Thr Leu Arg Val Leu 
        355                 360                 365             

<210>   110
<211>   385
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 103

<400>   110
Met Arg Met Arg Ile Glu Ser Thr Gly Ser Arg Leu Asn Arg Thr Val 
                5                   10                  15      

Arg Ile Gly Val Asp Cys Arg Pro Leu Val Gly Asp Lys Thr Gly Leu 
            20                  25                  30          

Gly Tyr Tyr Leu Trp Glu Ile Leu Asp Glu Trp Ala Arg Ala Glu Ile 
        35                  40                  45              

Asp Phe Val Glu Leu Tyr Leu Tyr Ala Ser Lys Pro Phe Glu Leu Pro 
    50                  55                  60                  

Ser Ala Phe Ala Asn Thr Arg Leu Leu Tyr Arg Lys Arg Val Arg Arg 
65                  70                  75                  80  

Leu Ser Pro Gly Glu Leu Trp Ala Gln Thr Ala Leu Pro Val Leu Val 
                85                  90                  95      

Ala Arg Asp Gly Ile Asp Val Phe Trp Gly Pro Asn Phe Cys Leu Pro 
            100                 105                 110         

Leu Leu Cys His Val Pro Thr Val Leu Thr Ile His Asp Met Val Tyr 
        115                 120                 125             

Lys Val Leu Pro Asp Thr Met Met Arg Lys Thr Tyr Tyr His Asn Ala 
    130                 135                 140                 

Phe Gly Leu Pro Leu Tyr Ala Arg Lys Ser Gln Lys Ile Leu Val Pro 
145                 150                 155                 160 

Ser Val Asn Thr Lys Leu Asp Val Val Lys Tyr Leu Arg Val Ala Glu 
                165                 170                 175     

Asp Arg Val Val Val Thr Pro Leu Gly Met Pro Lys Arg Phe Arg Gln 
            180                 185                 190         

Glu Leu Asp Thr Gly Ile Ile Leu Ser His Arg Phe Gly Leu Glu Met 
        195                 200                 205             

Gly Ser Tyr Ile Leu Ala Val Gly Thr Val Glu Pro Arg Lys Asn Leu 
    210                 215                 220                 

Glu Arg Val Val Arg Ala Phe Arg Leu Ala Arg Lys Ala His Pro Asp 
225                 230                 235                 240 

Met Lys Leu Val Val Ala Gly Thr Leu Gly Trp Ala Ser Glu Gln Thr 
                245                 250                 255     

Gln Ser Ala Leu Gln Asp Glu Gly Val Ile Tyr Val Gly Tyr Val Ser 
            260                 265                 270         

Asp Val Glu Leu Met Ala Leu Tyr Lys Gly Cys Arg Phe Phe Val Tyr 
        275                 280                 285             

Val Pro Leu Tyr Glu Gly Phe Gly Met Pro Pro Leu Glu Ala Met Ala 
    290                 295                 300                 

Val Gly Lys Pro Val Leu Thr Ala Asn Asn Ser Ser Leu Pro Glu Val 
305                 310                 315                 320 

Val Gly Arg Ala Ala Ile Leu Val Asp Ala Thr Arg Glu Glu Cys Ile 
                325                 330                 335     

Arg Glu Gly Met Ser Leu Leu Trp Val Asp Gly Asp Leu Arg Glu Arg 
            340                 345                 350         

Leu Ser Glu Gln Ala Leu Ala Arg Ala Arg Lys Phe Ser Trp Asp Glu 
        355                 360                 365             

Thr Ala Gln Lys Thr Leu Asn Val Ile Leu Asn Val Val Gly Ala Gln 
    370                 375                 380                 

Thr 
385 

<210>   111
<211>   385
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 103

<400>   111
Met Arg Met Arg Ile Glu Ser Thr Gly Ser Arg Leu Asn Arg Thr Val 
                5                   10                  15      

Arg Ile Gly Val Asp Cys Arg Pro Leu Val Gly Asp Lys Thr Gly Ile 
            20                  25                  30          

Gly Tyr Tyr Leu Trp Glu Ile Leu Asp Glu Trp Ala Arg Ala Glu Ile 
        35                  40                  45              

Asp Phe Val Glu Leu Tyr Leu Tyr Ala Ser Lys Pro Phe Glu Leu Pro 
    50                  55                  60                  

Ser Ala Phe Ala Asn Thr Arg Leu Leu Tyr Arg Lys Arg Val Arg Arg 
65                  70                  75                  80  

Leu Ser Pro Gly Glu Leu Trp Ala Gln Thr Ala Leu Pro Val Leu Val 
                85                  90                  95      

Ala Arg Asp Gly Ile Asp Val Phe Trp Gly Pro Asn Phe Cys Leu Pro 
            100                 105                 110         

Leu Leu Cys His Val Pro Thr Val Leu Thr Ile His Asp Met Val Tyr 
        115                 120                 125             

Lys Val Leu Pro Asp Thr Met Met Arg Lys Thr Tyr Tyr His Asn Ala 
    130                 135                 140                 

Phe Gly Leu Pro Leu Tyr Ala Arg Lys Ser Gln Lys Ile Leu Val Pro 
145                 150                 155                 160 

Ser Val Asn Thr Lys Leu Asp Val Val Lys Tyr Leu Arg Val Ala Glu 
                165                 170                 175     

Asp Arg Val Val Val Thr Pro Leu Gly Met Pro Lys Arg Phe Arg Gln 
            180                 185                 190         

Glu Leu Asp Thr Gly Ile Ile Leu Ser His Arg Phe Gly Leu Glu Met 
        195                 200                 205             

Gly Ser Tyr Ile Leu Ala Val Gly Thr Val Glu Pro Arg Lys Asn Leu 
    210                 215                 220                 

Glu Arg Val Val Arg Ala Phe Arg Leu Ala Arg Lys Ala His Pro Asp 
225                 230                 235                 240 

Met Lys Leu Val Val Ala Gly Thr Leu Gly Trp Ala Ser Glu Gln Thr 
                245                 250                 255     

Gln Ser Ala Leu Gln Asp Glu Gly Val Ile Tyr Val Gly Tyr Val Ser 
            260                 265                 270         

Asp Val Glu Leu Met Ala Leu Tyr Lys Gly Cys Arg Phe Phe Val Tyr 
        275                 280                 285             

Val Pro Leu Tyr Glu Gly Phe Gly Met Pro Pro Leu Glu Ala Met Ala 
    290                 295                 300                 

Val Gly Lys Pro Val Leu Thr Ala Asn Asn Ser Ser Leu Pro Glu Val 
305                 310                 315                 320 

Val Gly Arg Ala Ala Ile Leu Val Asp Ala Thr Arg Glu Glu Cys Ile 
                325                 330                 335     

Arg Glu Gly Met Ser Ile Leu Trp Val Asp Gly Asp Leu Arg Glu Arg 
            340                 345                 350         

Leu Ser Glu Gln Ala Leu Ala Arg Ala Arg Lys Phe Ser Trp Asp Glu 
        355                 360                 365             

Thr Ala Gln Lys Thr Leu Asn Val Ile Leu Asn Val Val Gly Ala Gln 
    370                 375                 380                 

Thr 
385 

<210>   112
<211>   385
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 103

<400>   112
Met Arg Met Arg Ile Glu Ser Thr Gly Ser Arg Leu Asn Arg Thr Val 
                5                   10                  15      

Arg Ile Gly Val Asp Cys Arg Pro Leu Val Gly Asp Lys Thr Gly Ile 
            20                  25                  30          

Gly Tyr Tyr Leu Trp Glu Ile Leu Asp Glu Trp Ala Arg Ala Glu Ile 
        35                  40                  45              

Asp Phe Val Glu Leu Tyr Leu Tyr Ala Ser Lys Pro Phe Glu Leu Pro 
    50                  55                  60                  

Ser Ala Phe Ala Asn Thr Arg Leu Leu Tyr Arg Lys Arg Val Arg Arg 
65                  70                  75                  80  

Leu Ser Pro Gly Glu Leu Trp Ala Gln Thr Ala Leu Pro Val Leu Val 
                85                  90                  95      

Ala Arg Asp Gly Ile Asp Val Phe Trp Gly Pro Asn Phe Cys Leu Pro 
            100                 105                 110         

Leu Leu Cys His Val Pro Thr Val Leu Thr Ile His Asp Met Val Tyr 
        115                 120                 125             

Lys Val Leu Pro Asp Thr Met Met Arg Lys Thr Tyr Tyr His Asn Ala 
    130                 135                 140                 

Phe Gly Leu Pro Leu Tyr Ala Arg Lys Ser Gln Arg Ile Leu Val Pro 
145                 150                 155                 160 

Ser Val Asn Thr Lys Leu Asp Val Val Lys Tyr Leu Arg Val Ala Glu 
                165                 170                 175     

Asp Arg Val Val Val Thr Pro Leu Gly Met Pro Lys Arg Phe Arg Gln 
            180                 185                 190         

Glu Leu Asp Thr Gly Ile Ile Leu Ser His Arg Phe Gly Leu Glu Met 
        195                 200                 205             

Gly Ser Tyr Ile Leu Ala Val Gly Thr Val Glu Pro Arg Lys Asn Leu 
    210                 215                 220                 

Glu Arg Val Val Arg Ala Phe Arg Leu Ala Arg Lys Ala His Pro Asp 
225                 230                 235                 240 

Met Lys Leu Val Val Ala Gly Thr Leu Gly Trp Ala Ser Glu Gln Thr 
                245                 250                 255     

Gln Ser Ala Leu Gln Asp Glu Gly Val Ile Tyr Val Gly Tyr Val Ser 
            260                 265                 270         

Asp Val Glu Leu Met Ala Leu Tyr Lys Gly Cys Arg Phe Phe Val Tyr 
        275                 280                 285             

Val Pro Leu Tyr Glu Gly Phe Gly Met Pro Pro Leu Glu Ala Met Ala 
    290                 295                 300                 

Val Gly Lys Pro Val Leu Thr Ala Asn Asn Ser Ser Leu Pro Glu Val 
305                 310                 315                 320 

Val Gly Arg Ala Ala Ile Leu Val Asp Ala Thr Arg Glu Glu Cys Ile 
                325                 330                 335     

Arg Glu Gly Met Ser Leu Leu Trp Val Asp Gly Asp Leu Arg Glu Arg 
            340                 345                 350         

Leu Ser Glu Gln Ala Leu Ala Arg Ala Arg Lys Phe Ser Trp Asp Glu 
        355                 360                 365             

Thr Ala Gln Lys Thr Leu Asn Val Ile Leu Asn Val Val Gly Ala Gln 
    370                 375                 380                 

Thr 
385 

<210>   113
<211>   385
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 103

<400>   113
Met Arg Met Arg Ile Glu Ser Thr Gly Ser Arg Leu Asn Arg Thr Val 
                5                   10                  15      

Arg Ile Gly Val Asp Cys Arg Pro Leu Val Gly Asp Lys Thr Gly Ile 
            20                  25                  30          

Gly Tyr Tyr Leu Trp Glu Ile Leu Asp Glu Trp Ala Arg Ala Glu Ile 
        35                  40                  45              

Asp Phe Val Glu Leu Tyr Leu Tyr Ala Ser Lys Pro Phe Glu Leu Pro 
    50                  55                  60                  

Ser Ala Phe Ala Asn Thr Arg Leu Leu Tyr Arg Lys Arg Val Arg Arg 
65                  70                  75                  80  

Leu Ser Pro Gly Glu Leu Trp Ala Gln Thr Ala Leu Pro Val Leu Val 
                85                  90                  95      

Ala Arg Asp Gly Leu Asp Val Phe Trp Gly Pro Asn Phe Cys Leu Pro 
            100                 105                 110         

Leu Leu Cys His Val Pro Thr Val Leu Thr Ile His Asp Met Val Tyr 
        115                 120                 125             

Lys Val Leu Pro Asp Thr Met Met Arg Lys Thr Tyr Tyr His Asn Ala 
    130                 135                 140                 

Phe Gly Leu Pro Leu Tyr Ala Arg Lys Ser Gln Lys Ile Leu Val Pro 
145                 150                 155                 160 

Ser Val Asn Thr Lys Leu Asp Val Val Lys Tyr Leu Arg Val Ala Glu 
                165                 170                 175     

Asp Arg Val Val Val Thr Pro Leu Gly Met Pro Lys Arg Phe Arg Gln 
            180                 185                 190         

Glu Leu Asp Thr Gly Ile Ile Leu Ser His Arg Phe Gly Leu Glu Met 
        195                 200                 205             

Gly Ser Tyr Ile Leu Ala Val Gly Thr Val Glu Pro Arg Lys Asn Leu 
    210                 215                 220                 

Glu Arg Val Val Arg Ala Phe Arg Leu Ala Arg Lys Ala His Pro Asp 
225                 230                 235                 240 

Met Lys Leu Val Val Ala Gly Thr Leu Gly Trp Ala Ser Glu Gln Thr 
                245                 250                 255     

Gln Ser Ala Leu Gln Asp Glu Gly Val Ile Tyr Val Gly Tyr Val Ser 
            260                 265                 270         

Asp Val Glu Leu Met Ala Leu Tyr Lys Gly Cys Arg Phe Phe Val Tyr 
        275                 280                 285             

Val Pro Leu Tyr Glu Gly Phe Gly Met Pro Pro Leu Glu Ala Met Ala 
    290                 295                 300                 

Val Gly Lys Pro Val Leu Thr Ala Asn Asn Ser Ser Leu Pro Glu Val 
305                 310                 315                 320 

Val Gly Arg Ala Ala Ile Leu Val Asp Ala Thr Arg Glu Glu Cys Ile 
                325                 330                 335     

Arg Glu Gly Met Ser Leu Leu Trp Val Asp Gly Asp Leu Arg Glu Arg 
            340                 345                 350         

Leu Ser Glu Gln Ala Leu Ala Arg Ala Arg Lys Phe Ser Trp Asp Glu 
        355                 360                 365             

Thr Ala Gln Lys Thr Leu Asn Val Ile Leu Asn Val Val Gly Ala Gln 
    370                 375                 380                 

Thr 
385 

<210>   114
<211>   385
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 103

<400>   114
Met Arg Met Arg Ile Glu Ser Thr Gly Ser Arg Leu Asn Arg Thr Val 
                5                   10                  15      

Arg Ile Gly Val Asp Cys Arg Pro Leu Val Gly Asp Lys Thr Gly Ile 
            20                  25                  30          

Gly Tyr Tyr Leu Trp Glu Ile Leu Asp Glu Trp Ala Arg Ala Glu Ile 
        35                  40                  45              

Asp Phe Val Glu Leu Tyr Leu Tyr Ala Ser Lys Pro Phe Glu Leu Pro 
    50                  55                  60                  

Ser Ala Phe Ala Asn Thr Arg Leu Leu Tyr Arg Lys Arg Val Arg Arg 
65                  70                  75                  80  

Leu Ser Pro Gly Glu Leu Trp Ala Gln Thr Ala Leu Pro Val Leu Val 
                85                  90                  95      

Ala Arg Asp Gly Ile Asp Val Phe Trp Gly Pro Asn Phe Cys Leu Pro 
            100                 105                 110         

Leu Leu Cys His Val Pro Thr Val Leu Thr Ile His Asp Met Val Tyr 
        115                 120                 125             

Lys Val Leu Pro Asp Thr Met Met Arg Lys Thr Tyr Tyr His Asn Ala 
    130                 135                 140                 

Phe Gly Leu Pro Leu Tyr Ala Arg Lys Ser Gln Lys Ile Leu Val Pro 
145                 150                 155                 160 

Ser Val Asn Thr Lys Leu Asp Val Val Lys Tyr Leu Arg Val Ala Glu 
                165                 170                 175     

Asp Arg Val Val Val Thr Pro Leu Gly Met Pro Lys Arg Phe Arg Gln 
            180                 185                 190         

Glu Leu Asp Thr Gly Ile Ile Leu Ser His Arg Phe Gly Leu Glu Met 
        195                 200                 205             

Gly Ser Tyr Ile Leu Ala Val Gly Thr Val Glu Pro Arg Lys Asn Leu 
    210                 215                 220                 

Glu Arg Val Val Arg Ala Phe Arg Leu Ala Arg Lys Ala His Pro Asp 
225                 230                 235                 240 

Met Lys Leu Val Val Ala Gly Thr Leu Gly Trp Ala Ser Glu Gln Thr 
                245                 250                 255     

Gln Ser Ala Leu Gln Asp Glu Gly Val Ile Tyr Val Gly Tyr Val Ser 
            260                 265                 270         

Asp Val Glu Leu Met Ala Leu Tyr Lys Gly Cys Arg Phe Phe Val Tyr 
        275                 280                 285             

Val Pro Leu Tyr Glu Gly Phe Gly Met Pro Pro Leu Glu Ala Met Ala 
    290                 295                 300                 

Val Gly Lys Pro Val Leu Thr Ala Asn Asn Ser Ser Leu Pro Glu Val 
305                 310                 315                 320 

Val Gly Arg Ala Ala Ile Leu Val Asp Ala Thr Arg Glu Glu Cys Ile 
                325                 330                 335     

Arg Glu Gly Met Ser Leu Leu Trp Val Asp Gly Asp Leu Arg Asp Arg 
            340                 345                 350         

Leu Ser Glu Gln Ala Leu Ala Arg Ala Arg Lys Phe Ser Trp Asp Glu 
        355                 360                 365             

Thr Ala Gln Lys Thr Leu Asn Val Ile Leu Asn Val Val Gly Ala Gln 
    370                 375                 380                 

Thr 
385 

<210>   115
<211>   1158
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 104

<400>   115
atgagaatgc gtattgagag cactggaagt cgtttgaacc gcacggtgcg aattggcgtg       60

gactgcaggc cgcttgtcgg agataagacc gggttaggtt attatttgtg ggaaattctc      120

gacgaatggg ctcgagccga gattgatttc gtcgagcttt atctgtacgc atccaagccc      180

tttgaactcc cgagtgcgtt tgcgaacacc agactcctat atcggaagcg tgtgcgtcgg      240

ctttcgccag gagaattatg ggcgcagact gcacttcctg tacttgtggc ccgtgatggc      300

attgatgtgt tttgggggcc gaatttttgt ttgcctcttt tgtgccatgt accgactgta      360

cttacgattc acgatatggt gtacaaagtg ctacccgata cgatgatgag aaagacgtat      420

tatcacaatg cgttcgggct gcctctttac gcgcgaaaat cacagaagat cctagtgcca      480

tctgtcaaca caaaattgga tgtcgtcaaa tatcttcgag tcgccgaaga tcgtgtggtt      540

gtcacgccgc taggcatgcc gaagcgcttc cggcaggaat tagatacggg aataattctt      600

tcgcataggt tcggacttga gatgggatcg tacattttgg ccgtgggtac cgtggaacca      660

agaaaaaatt tggagcgtgt tgttcgggcg tttcgattgg ctcgaaaagc tcatccagat      720

atgaagttgg ttgtggctgg tacattgggg tgggcttcgg agcaaacgca atcggctttg      780

caagatgagg gagtcatcta tgttggctac gtgtctgatg ttgagctgat ggcattatac      840

aaagggtgta ggttttttgt gtatgtaccg ttatacgagg gttttggcat gccgccactt      900

gaggccatgg cggttggtaa gccggtatta acggcaaaca acagttctct cccagaagtt      960

gttgggcggg ccgcgatctt ggtggacgcc acgcgtgagg agtgtataag ggagggaatg     1020

tccttgcttt gggttgatgg tgacttaagg gagcgcttgt ctgagcaagc gttggcccgg     1080

gctcgaaagt tctcatggga tgaaactgct cagaaaacgc tcaacgtcat cttgaacgtg     1140

gttggtgccc agacgtga                                                   1158


<210>   116
<211>   1158
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 104

<400>   116
atgagaatgc gtattgagag cactggaagt cgtttgaacc gcacggtgcg aattggcgtg       60

gactgcaggc cgcttgtcgg agataagacc gggattggtt attatttgtg ggaaattctc      120

gacgaatggg ctcgagccga gattgatttc gtcgagcttt atctgtacgc atccaagccc      180

tttgaactcc cgagtgcgtt tgcgaacacc agactcctat atcggaagcg tgtgcgtcgg      240

ctttcgccag gagaattatg ggcgcagact gcacttcctg tacttgtggc ccgtgatggc      300

attgatgtgt tttgggggcc gaatttttgt ttgcctcttt tgtgccatgt accgactgta      360

cttacgattc acgatatggt gtacaaagtg ctacccgata cgatgatgag aaagacgtat      420

tatcacaatg cgttcgggct gcctctttac gcgcgaaaat cacagaagat cctagtgcca      480

tctgtcaaca caaaattgga tgtcgtcaaa tatcttcgag tcgccgaaga tcgtgtggtt      540

gtcacgccgc taggcatgcc gaagcgcttc cggcaggaat tagatacggg aataattctt      600

tcgcataggt tcggacttga gatgggatcg tacattttgg ccgtgggtac cgtggaacca      660

agaaaaaatt tggagcgtgt tgttcgggcg tttcgattgg ctcgaaaagc tcatccagat      720

atgaagttgg ttgtggctgg tacattgggg tgggcttcgg agcaaacgca atcggctttg      780

caagatgagg gagtcatcta tgttggctac gtgtctgatg ttgagctgat ggcattatac      840

aaagggtgta ggttttttgt gtatgtaccg ttatacgagg gttttggcat gccgccactt      900

gaggccatgg cggttggtaa gccggtatta acggcaaaca acagttctct cccagaagtt      960

gttgggcggg ccgcgatctt ggtggacgcc acgcgtgagg agtgtataag ggagggaatg     1020

tccattcttt gggttgatgg tgacttaagg gagcgcttgt ctgagcaagc gttggcccgg     1080

gctcgaaagt tctcatggga tgaaactgct cagaaaacgc tcaacgtcat cttgaacgtg     1140

gttggtgccc agacgtga                                                   1158


<210>   117
<211>   1158
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 104

<400>   117
atgagaatgc gtattgagag cactggaagt cgtttgaacc gcacggtgcg aattggcgtg       60

gactgcaggc cgcttgtcgg agataagacc gggattggtt attatttgtg ggaaattctc      120

gacgaatggg ctcgagccga gattgatttc gtcgagcttt atctgtacgc atccaagccc      180

tttgaactcc cgagtgcgtt tgcgaacacc agactcctat atcggaagcg tgtgcgtcgg      240

ctttcgccag gagaattatg ggcgcagact gcacttcctg tacttgtggc ccgtgatggc      300

attgatgtgt tttgggggcc gaatttttgt ttgcctcttt tgtgccatgt accgactgta      360

cttacgattc acgatatggt gtacaaagtg ctacccgata cgatgatgag aaagacgtat      420

tatcacaatg cgttcgggct gcctctttac gcgcgaaaat cacagcgtat cctagtgcca      480

tctgtcaaca caaaattgga tgtcgtcaaa tatcttcgag tcgccgaaga tcgtgtggtt      540

gtcacgccgc taggcatgcc gaagcgcttc cggcaggaat tagatacggg aataattctt      600

tcgcataggt tcggacttga gatgggatcg tacattttgg ccgtgggtac cgtggaacca      660

agaaaaaatt tggagcgtgt tgttcgggcg tttcgattgg ctcgaaaagc tcatccagat      720

atgaagttgg ttgtggctgg tacattgggg tgggcttcgg agcaaacgca atcggctttg      780

caagatgagg gagtcatcta tgttggctac gtgtctgatg ttgagctgat ggcattatac      840

aaagggtgta ggttttttgt gtatgtaccg ttatacgagg gttttggcat gccgccactt      900

gaggccatgg cggttggtaa gccggtatta acggcaaaca acagttctct cccagaagtt      960

gttgggcggg ccgcgatctt ggtggacgcc acgcgtgagg agtgtataag ggagggaatg     1020

tccttgcttt gggttgatgg tgacttaagg gagcgcttgt ctgagcaagc gttggcccgg     1080

gctcgaaagt tctcatggga tgaaactgct cagaaaacgc tcaacgtcat cttgaacgtg     1140

gttggtgccc agacgtga                                                   1158


<210>   118
<211>   1158
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 104

<400>   118
atgagaatgc gtattgagag cactggaagt cgtttgaacc gcacggtgcg aattggcgtg       60

gactgcaggc cgcttgtcgg agataagacc gggattggtt attatttgtg ggaaattctc      120

gacgaatggg ctcgagccga gattgatttc gtcgagcttt atctgtacgc atccaagccc      180

tttgaactcc cgagtgcgtt tgcgaacacc agactcctat atcggaagcg tgtgcgtcgg      240

ctttcgccag gagaattatg ggcgcagact gcacttcctg tacttgtggc ccgtgatggc      300

ttagatgtgt tttgggggcc gaatttttgt ttgcctcttt tgtgccatgt accgactgta      360

cttacgattc acgatatggt gtacaaagtg ctacccgata cgatgatgag aaagacgtat      420

tatcacaatg cgttcgggct gcctctttac gcgcgaaaat cacagaagat cctagtgcca      480

tctgtcaaca caaaattgga tgtcgtcaaa tatcttcgag tcgccgaaga tcgtgtggtt      540

gtcacgccgc taggcatgcc gaagcgcttc cggcaggaat tagatacggg aataattctt      600

tcgcataggt tcggacttga gatgggatcg tacattttgg ccgtgggtac cgtggaacca      660

agaaaaaatt tggagcgtgt tgttcgggcg tttcgattgg ctcgaaaagc tcatccagat      720

atgaagttgg ttgtggctgg tacattgggg tgggcttcgg agcaaacgca atcggctttg      780

caagatgagg gagtcatcta tgttggctac gtgtctgatg ttgagctgat ggcattatac      840

aaagggtgta ggttttttgt gtatgtaccg ttatacgagg gttttggcat gccgccactt      900

gaggccatgg cggttggtaa gccggtatta acggcaaaca acagttctct cccagaagtt      960

gttgggcggg ccgcgatctt ggtggacgcc acgcgtgagg agtgtataag ggagggaatg     1020

tccttgcttt gggttgatgg tgacttaagg gagcgcttgt ctgagcaagc gttggcccgg     1080

gctcgaaagt tctcatggga tgaaactgct cagaaaacgc tcaacgtcat cttgaacgtg     1140

gttggtgccc agacgtga                                                   1158


<210>   119
<211>   1158
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 104

<400>   119
atgagaatgc gtattgagag cactggaagt cgtttgaacc gcacggtgcg aattggcgtg       60

gactgcaggc cgcttgtcgg agataagacc gggattggtt attatttgtg ggaaattctc      120

gacgaatggg ctcgagccga gattgatttc gtcgagcttt atctgtacgc atccaagccc      180

tttgaactcc cgagtgcgtt tgcgaacacc agactcctat atcggaagcg tgtgcgtcgg      240

ctttcgccag gagaattatg ggcgcagact gcacttcctg tacttgtggc ccgtgatggc      300

attgatgtgt tttgggggcc gaatttttgt ttgcctcttt tgtgccatgt accgactgta      360

cttacgattc acgatatggt gtacaaagtg ctacccgata cgatgatgag aaagacgtat      420

tatcacaatg cgttcgggct gcctctttac gcgcgaaaat cacagaagat cctagtgcca      480

tctgtcaaca caaaattgga tgtcgtcaaa tatcttcgag tcgccgaaga tcgtgtggtt      540

gtcacgccgc taggcatgcc gaagcgcttc cggcaggaat tagatacggg aataattctt      600

tcgcataggt tcggacttga gatgggatcg tacattttgg ccgtgggtac cgtggaacca      660

agaaaaaatt tggagcgtgt tgttcgggcg tttcgattgg ctcgaaaagc tcatccagat      720

atgaagttgg ttgtggctgg tacattgggg tgggcttcgg agcaaacgca atcggctttg      780

caagatgagg gagtcatcta tgttggctac gtgtctgatg ttgagctgat ggcattatac      840

aaagggtgta ggttttttgt gtatgtaccg ttatacgagg gttttggcat gccgccactt      900

gaggccatgg cggttggtaa gccggtatta acggcaaaca acagttctct cccagaagtt      960

gttgggcggg ccgcgatctt ggtggacgcc acgcgtgagg agtgtataag ggagggaatg     1020

tccttgcttt gggttgatgg tgacttaagg gatcgcttgt ctgagcaagc gttggcccgg     1080

gctcgaaagt tctcatggga tgaaactgct cagaaaacgc tcaacgtcat cttgaacgtg     1140

gttggtgccc agacgtga                                                   1158


<210>   120
<211>   506
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   120
Met Val Ser Leu Thr Ile Ser Leu Leu Ala Asp Ile Tyr Glu Gly Arg 
                5                   10                  15      

His Gly Phe Ala Gly Ile Ser Thr Asp Met Arg Thr Thr Tyr Ala Gly 
            20                  25                  30          

Leu Ala Ser Thr Ala Asp Ile Ser Leu Thr Gly Leu Ile Tyr Ala Gln 
        35                  40                  45              

Arg Pro Leu Gly Asn Glu Ser Val Val Arg His Leu Leu Met Met Ser 
    50                  55                  60                  

Arg Pro Asp Leu Met Arg Leu Ala His Glu Ile Ala Gly His Arg Val 
65                  70                  75                  80  

Pro Asp Asn Val Phe Ala Thr Met Glu His Met Leu Ser Gly Lys Arg 
                85                  90                  95      

Gly Met Met Leu Gly Asp Leu Ser Arg Val Val Arg Trp Ala Leu Leu 
            100                 105                 110         

Thr Thr Arg Thr Tyr Arg Thr His Pro Ile Asp Ser Asp Val Tyr Tyr 
        115                 120                 125             

Asp Leu Ile Trp Arg Phe Phe Phe Glu Lys Thr Leu Ala Pro Lys Glu 
    130                 135                 140                 

Leu Glu Asn Val Arg Gln Thr Gln Phe Val Ile Ser Gly Leu Ser His 
145                 150                 155                 160 

Ala Ile Gly Asn Ala Thr Leu Lys Arg Trp Gly Arg Pro Leu Arg Leu 
                165                 170                 175     

Asp Ala Arg Lys Trp Asp Val Val Leu Thr Phe Asn Val Ser Pro Ile 
            180                 185                 190         

Glu Phe Val Gly Arg Arg Ile Thr Arg Val His Asp Leu Ile Pro Leu 
        195                 200                 205             

Val Arg Pro Asp Phe Val Pro Ile Glu His Ala Glu Ile Phe Lys Ala 
    210                 215                 220                 

Gln Leu Glu Leu Thr Leu Arg Asn Ser Gln Ala Ile Val Thr Val Ser 
225                 230                 235                 240 

Lys Cys Ala Ala Gly Asp Leu Val Arg Leu Tyr Pro Asn Thr Gln Ser 
                245                 250                 255     

Lys Ile Glu Ile Ile Pro Cys Ala Thr Ser Arg Arg Tyr Tyr Arg Asp 
            260                 265                 270         

Leu Ser Ser Ile Pro Leu Gln Arg Ile Val Glu Arg Arg Leu Ser Glu 
        275                 280                 285             

Phe His Arg His Cys Arg Lys Arg Asp Arg Arg Leu Pro Gln Ile Thr 
    290                 295                 300                 

Pro Phe Lys Tyr Phe Ile Tyr His Gly Thr Ile Glu Pro Lys Lys Asn 
305                 310                 315                 320 

Val Lys Thr Leu Leu Leu Ala Phe Asp Ser Leu Val Asn Gln Glu Arg 
                325                 330                 335     

Phe Arg Glu Tyr Lys Leu Ile Ile Ala Gly Arg Phe Gly Trp Met Tyr 
            340                 345                 350         

Asp Gln Glu Arg Thr His Met Ala Lys Leu Ile Glu Lys Gly Ala Val 
        355                 360                 365             

Ile His Leu Glu Asp Thr Thr Asn Asp Glu Leu Arg Val Leu Leu Ser 
    370                 375                 380                 

Asn Ala Leu Ala His Val Phe Pro Ser Tyr Tyr Glu Gly Phe Gly Ile 
385                 390                 395                 400 

Pro Pro Val Glu Ala Leu Ser Cys Gly Cys Pro Thr Ile Val Ser Asn 
                405                 410                 415     

Val Ser Ser Leu Pro Glu Val Val Gly Arg Ala Gly Ile Leu Val Ser 
            420                 425                 430         

Pro Tyr Asp Ala Glu Trp Leu Ala Ser Glu Met Gly Ala Val Ala Leu 
        435                 440                 445             

Ala Pro Glu Ser Val Arg Glu Arg Ile Glu Arg Glu Ser Lys Tyr Val 
    450                 455                 460                 

Leu Glu Gln Tyr Ala Glu Ser Thr Val Arg Asp Lys Trp Met Arg Val 
465                 470                 475                 480 

Ile Glu Lys Ser Leu Ser Leu Gly Gly Arg Thr Ala Ser Thr Leu Met 
                485                 490                 495     

Ala Glu Asn Tyr Arg Val Asp Ser Val Leu 
            500                 505     

<210>   121
<211>   1521
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   121
gtggtttcgt tgacgatttc gttgctcgcg gatatctatg aaggacgaca tgggttcgcc       60

ggtatttcga cagacatgag aacgacgtat gctggcctgg cgtcgactgc cgacatatcg      120

ctcacgggac tcatttatgc tcagcgtccc ttgggcaacg aatcggtcgt gcggcatctt      180

ctgatgatgt ctcgccccga tttgatgcga ctcgctcacg aaatcgcagg gcatcgagtt      240

cccgataacg tcttcgcaac gatggagcac atgttgtctg gaaaacgagg tatgatgctg      300

ggcgacctgt cgcgtgtcgt taggtgggca cttttaacaa cgaggactta ccgtacccat      360

ccgatcgaca gtgacgttta ttatgacttg atatggcggt tcttttttga gaagacactg      420

gcgccaaagg aactcgagaa tgtacgccag acgcagtttg tgatatctgg cttgtctcac      480

gcaattggca acgcaacgct gaaaagatgg ggccgacctc ttcgattgga tgctagaaaa      540

tgggatgtgg ttcttacctt taacgtgtca cccatcgaat ttgtcggaag acggatcact      600

cgcgtgcatg acctcatacc attggttcgt ccggattttg tgcctattga gcatgctgag      660

atcttcaagg cacaactcga gttgacgctg aggaattcgc aggccattgt cacggtgtca      720

aagtgtgctg ccggcgatct ggtgcgttta tatccaaata cgcagtccaa aattgaaatc      780

atcccatgcg cgacgtctcg acgatattat cgtgatttat catcgattcc tctgcagcgt      840

attgtcgagc gaaggttgtc ggagtttcac aggcattgtc gcaagcgcga tcgccgatta      900

ccgcagatta cgccgttcaa atattttata tatcacggga cgatcgagcc gaagaaaaat      960

gtcaaaacgc ttctgctagc ctttgactct ttggtaaatc aagagcggtt tagagagtat     1020

aagctcatca ttgcaggaag atttggttgg atgtatgacc aagagcgtac gcatatggcg     1080

aaattgatcg agaaaggtgc cgtcattcat ctcgaggata caacgaacga tgaactcagg     1140

gttcttttaa gcaacgcatt ggctcatgtg tttccgtctt attacgaagg ttttggtata     1200

ccgcctgttg aggctttgtc gtgtgggtgt cccactattg tttcgaatgt ttcttctcta     1260

ccggaggttg tagggcgagc cgggatcctc gtcagtccgt atgatgcaga atggttggcc     1320

tcggaaatgg gggctgtggc gctggctcca gaatcagtac gagagcggat cgaacgagaa     1380

tccaaatatg tgttggaaca gtacgccgaa tcgactgttc gggacaagtg gatgagggta     1440

attgaaaagt cgcttagttt gggtgggcgt acagcctcaa cgctgatggc ggagaattac     1500

cgggtcgact cagtgctgta g                                               1521


<210>   122
<211>   265
<212>   PRT
<213>   Methanococcus aeolicus Nankai-3

<400>   122
Lys Ile Ile Thr Val Tyr Asp Val Ile Pro Leu Gln Phe Pro Glu Thr 
                5                   10                  15      

Tyr Ala Lys Ile Thr Val Phe Arg Tyr Lys Leu Leu Phe Ser Lys Thr 
            20                  25                  30          

Leu Asn Thr Ser Asn Lys Ile Ile Ser Ile Ser His His Thr Lys Gln 
        35                  40                  45              

Asp Leu Ile Lys His Phe Lys Ile Ser Glu Asp Lys Ile Lys Val Ile 
    50                  55                  60                  

His Leu Ala Ala Asn Glu Asn Tyr Lys Pro Leu Lys Glu Asn Glu Ile 
65                  70                  75                  80  

Asn Asn Ile Lys Gln Lys Tyr Asn Leu Asn Tyr Pro Phe Ile Leu Tyr 
                85                  90                  95      

Val Gly Thr Leu Glu Pro Arg Lys Asn Ile Pro Asn Leu Leu Lys Ala 
            100                 105                 110         

Leu Tyr Lys Leu Lys Lys His Ser Ile Lys His Lys Leu Val Ile Thr 
        115                 120                 125             

Gly Lys Lys Gly Trp Lys Tyr Lys Ser Ile Phe Glu Thr Ile Glu Lys 
    130                 135                 140                 

Leu Asn Leu Gln Lys Asp Val Ile Phe Thr Gly Tyr Val Pro Asp Glu 
145                 150                 155                 160 

Asp Leu Pro Ala Leu Tyr Asn Ala Ala Asp Leu Phe Val Tyr Pro Ser 
                165                 170                 175     

Leu Tyr Glu Gly Phe Gly Leu Pro Pro Leu Glu Ala Met Gln Cys Gly 
            180                 185                 190         

Thr Pro Val Ile Thr Ser Asn Thr Ser Ser Leu Pro Glu Val Val Gly 
        195                 200                 205             

Asp Ala Gly Ile Met Val Asn Pro Tyr Asp Val Asp Glu Leu Ala Asn 
    210                 215                 220                 

Lys Met Tyr Glu Val Leu Thr Asn Asp Gly Ile Arg Glu Glu Leu Ser 
225                 230                 235                 240 

Lys Lys Gly Ile Glu Arg Ala Lys Leu Phe Ser Trp Lys Lys Cys Ala 
                245                 250                 255     

Glu Glu His Leu Lys Val Tyr Glu Glu 
            260                 265 

<210>   123
<211>   297
<212>   PRT
<213>   Nitrosococcus oceani ATCC 19707

<400>   123
Tyr Glu Met Ala Asn Gln Thr Tyr Leu Arg Leu Gly Arg Leu Thr Arg 
                5                   10                  15      

Val Lys Phe Pro Arg Pro Pro Ala Leu Trp His Ala Thr Thr Pro Leu 
            20                  25                  30          

Pro Ile Arg Ile Arg Gly Ala Arg Met Val Thr Thr Val His Asp Leu 
        35                  40                  45              

Ile Pro Leu Arg Leu Pro Tyr Thr Thr Leu Asp Asn Lys Gln Phe Phe 
    50                  55                  60                  

Tyr Arg Leu Val Arg Asp Ala Leu Arg Asp Ser Asp Leu Val Leu Thr 
65                  70                  75                  80  

Val Ser Glu Cys Ser Lys Arg Asp Ile Leu Ala Phe Tyr Asp Ile Pro 
                85                  90                  95      

Glu Glu Arg Val Val Val Thr Tyr Gln Ser Leu Ser Leu Lys Lys Ala 
            100                 105                 110         

Ser Thr His Gln Arg Gln Ser Phe Ser Val Leu Lys Ser Tyr Gly Leu 
        115                 120                 125             

Thr Pro Gly Gln Tyr Val Leu Phe Val Gly Asn Ile Glu Pro Lys Lys 
    130                 135                 140                 

Asn Leu Ala Thr Leu Ile Lys Ala Met Ser Met Leu Gln His Asp Leu 
145                 150                 155                 160 

Pro Leu Val Val Val Gly Arg Lys Ala Trp Leu Trp Glu Glu Gln Leu 
                165                 170                 175     

Gln Met Ala Lys Arg Tyr Phe Gly Ser Asn Glu Ala Lys Arg Leu Arg 
            180                 185                 190         

Ile Leu Asp Tyr Val Pro Ser Thr Val Leu Ser Thr Leu Tyr Ser His 
        195                 200                 205             

Ala Leu Cys Met Ala Phe Pro Ser Leu Tyr Glu Gly Phe Gly Leu Pro 
    210                 215                 220                 

Ala Leu Glu Ala Met Ser His Gly Cys Pro Val Ile Ser Ser Asn Ala 
225                 230                 235                 240 

Ser Ser Leu Pro Glu Val Cys Gly Glu Ala Ala Leu Tyr Met Asp Pro 
                245                 250                 255     

His Asp Ser Asp Gly Leu Tyr Ala His Ile Glu Ser Leu Leu Glu Asp 
            260                 265                 270         

Val Cys Leu Arg Ala Arg Leu Ile Glu Gly Gly Tyr Arg Arg Val Glu 
        275                 280                 285             

Tyr Phe Ser Pro Glu Arg Tyr Ala Glu 
    290                 295         

<210>   124
<211>   263
<212>   PRT
<213>   Clostridium tetani E88

<400>   124
Lys Lys Ile Ile Thr Val His Asp Leu Ile Pro Tyr Thr Met Pro Glu 
                5                   10                  15      

Thr Val Gly Arg Gly Tyr Leu Lys Lys Phe Leu Arg Asn Met Pro Gln 
            20                  25                  30          

Leu Ile Tyr Asp Ala Asp Ala Ile Ile Thr Val Ser Lys Tyr Ser Lys 
        35                  40                  45              

Lys Asp Ile Leu Arg Phe Phe Pro Met Asp Glu Lys Lys Ile Phe Val 
    50                  55                  60                  

Thr His Leu Ala Ala Asp Glu Lys Tyr Arg Pro Leu Asn Lys Asp Lys 
65                  70                  75                  80  

Cys Asn Tyr Ile Leu Lys Asn His Tyr Asn Ile Asp Asn Pro Phe Ile 
                85                  90                  95      

Leu Tyr Ile Gly Gly Phe Ser Pro Arg Lys Asn Ile Lys Ser Leu Leu 
            100                 105                 110         

Ile Ser Phe Ser Lys Ile Tyr Lys Asn Leu Asp Lys Asp Tyr Lys Leu 
        115                 120                 125             

Val Ile Val Gly Ala Asn Lys Asn Gly Thr Lys Ile Leu Met Asp Met 
    130                 135                 140                 

Ala Lys Asp Leu Asn Ile Glu Ser Lys Ile Ile Phe Thr Gly Phe Val 
145                 150                 155                 160 

Pro Glu Asp His Leu Pro Ile Leu Tyr Asn Ser Cys Glu Thr Phe Val 
                165                 170                 175     

Tyr Pro Ser Leu Tyr Glu Gly Phe Gly Leu Pro Pro Leu Glu Ala Met 
            180                 185                 190         

Cys Cys Gly Thr Pro Val Ile Thr Ser Asn Val Thr Ser Ile Pro Glu 
        195                 200                 205             

Val Val Gly Asp Gly Gly Ile Leu Ile Asn Pro Asn Asp Ile Asp Glu 
    210                 215                 220                 

Leu Ser Asn Ser Leu Glu Lys Thr Leu Leu Asp Val Ser Phe Lys Tyr 
225                 230                 235                 240 

Glu Leu Lys Lys Lys Ala Leu Glu Arg Ser Ser Leu Tyr Ser Trp Glu 
                245                 250                 255     

Asn Thr Ala Lys Asn Thr Leu 
            260             

<210>   125
<211>   270
<212>   PRT
<213>   Chloroflexus aurantiacus J-10-fl

<400>   125
Trp Gln Arg Leu Arg Leu Pro Leu Arg Ile Glu Trp Phe Val Gly Pro 
                5                   10                  15      

Leu Asp Ile Val His Ala Pro Asp Phe Val Leu Pro Pro Thr Lys Ala 
            20                  25                  30          

Arg Thr Leu Leu Thr Ile His Asp Leu Thr Phe Leu Val Glu Pro Ala 
        35                  40                  45              

Cys Ala Glu Pro Asn Leu Arg Arg Tyr Leu Ser Thr Ala Val Pro Arg 
    50                  55                  60                  

Ser Leu Gln Arg Ala Asn Leu Ile Ile Val Asp Ser Lys Ala Thr Ala 
65                  70                  75                  80  

Gly Asp Leu Gly Arg Leu Tyr Gly Ile Pro Arg Gln Arg Val Arg Leu 
                85                  90                  95      

Leu Tyr Pro Ala Val Asp Glu Arg Phe Arg Pro Leu Thr Gly Asp Ala 
            100                 105                 110         

Val Val Arg Val Arg Glu Arg Leu His Leu Pro Ala Arg Phe Leu Leu 
        115                 120                 125             

Phe Val Gly Thr Leu Glu Pro Arg Lys Asn Leu Val Arg Leu Leu Gln 
    130                 135                 140                 

Ala Phe Ala Leu Leu Gln Asn Glu Tyr Pro Asp Leu His Leu Leu Leu 
145                 150                 155                 160 

Ala Gly Arg Lys Gly Trp Leu Tyr Asp Asp Ile Phe Ala Ala Val Glu 
                165                 170                 175     

Gln Tyr His Leu Ser Glu Arg Val His Phe Leu Asp Phe Val Ala Asp 
            180                 185                 190         

Glu Asp Leu Pro Ala Leu Tyr Asn Leu Ala Glu Ala Phe Val Tyr Pro 
        195                 200                 205             

Ser Leu Tyr Glu Gly Phe Gly Phe Pro Val Leu Glu Ala Leu Ala Cys 
    210                 215                 220                 

Gly Thr Pro Val Val Thr Thr Lys Val Ser Ser Leu Pro Glu Val Ala 
225                 230                 235                 240 

Gly Thr Ala Ala Ile Phe Val Asp Pro Leu Glu Pro Glu Asp Ile Ala 
                245                 250                 255     

Asp Gly Ile Arg Thr Ala Leu Ser Asn Pro Ala Ser Leu Arg 
            260                 265                 270 

<210>   126
<211>   271
<212>   PRT
<213>   Bacteroides vulgatus ATCC 8482

<400>   126
Phe Lys Val Lys Arg Ile Val Thr Ile His Asp Leu Thr Phe Phe Ile 
                5                   10                  15      

His Pro Ser Val His Thr Phe Ile Lys Arg Tyr Tyr Phe Arg Leu Phe 
            20                  25                  30          

Ile Lys Leu Ala Cys Arg Tyr Ala Asp Arg Leu Ile Cys Val Ser Glu 
        35                  40                  45              

Ser Thr Lys Lys Asp Leu Glu Arg Ile Cys Gly Arg Arg Ser Val Ser 
    50                  55                  60                  

Ile Asp Val Ile Pro Leu Ser Cys Ser Pro Lys Met Gln Val Gly Glu 
65                  70                  75                  80  

Gln Glu Leu Glu Leu Val Lys Lys Lys Phe Gly Val Val Ser Gln Tyr 
                85                  90                  95      

Met Leu Phe Ile Gly Thr Leu Glu Pro Arg Lys Asn Ile Leu Asn Leu 
            100                 105                 110         

Ile Asn Ala Phe Tyr Lys Phe Ser Gln Lys Asn Arg Asp Tyr Ser Leu 
        115                 120                 125             

Val Ile Ile Gly Lys Lys Gly Trp Phe Tyr Glu Ser Ile Phe Lys Leu 
    130                 135                 140                 

Val Glu Glu Leu His Leu Glu Arg Ser Val Val Phe Thr Gly Phe Val 
145                 150                 155                 160 

Thr Thr Lys Glu Lys Phe Ile Leu Leu Ser Gly Ala His Ser Phe Ile 
                165                 170                 175     

Tyr Pro Ser Ile Tyr Glu Gly Phe Gly Leu Pro Val Leu Glu Ala Ile 
            180                 185                 190         

Thr Tyr Gly Ile Pro Thr Ile Thr Ser Lys Leu Ser Ser Leu Pro Glu 
        195                 200                 205             

Val Ala Gly Asn Ala Ala Leu Tyr Ile Asn Pro Tyr Asp Val Gln Ser 
    210                 215                 220                 

Ile Ser Asp Ala Ile Glu Ser Val Asn Cys Asp Glu Glu Thr Arg Arg 
225                 230                 235                 240 

Lys Leu Ile Lys Asn Ser Glu Lys Gln Arg Leu Lys Tyr Ser Trp Lys 
                245                 250                 255     

Lys Thr Ala Asn Leu Thr Tyr Ser Leu Tyr Asn Arg Cys Gly Ser 
            260                 265                 270     

<210>   127
<211>   506
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 120

<400>   127
Met Val Ser Leu Thr Ile Ser Leu Leu Ala Asp Ile Tyr Glu Gly Arg 
                5                   10                  15      

His Gly Phe Ala Gly Ile Ser Thr Asp Met Arg Thr Thr Tyr Ala Gly 
            20                  25                  30          

Leu Ala Ser Thr Ala Asp Ile Ser Leu Thr Gly Leu Ile Tyr Ala Gln 
        35                  40                  45              

Arg Pro Leu Gly Asn Glu Ser Val Val Arg His Leu Leu Met Met Ser 
    50                  55                  60                  

Arg Pro Asp Leu Met Arg Leu Ala His Glu Ile Ala Gly His Arg Val 
65                  70                  75                  80  

Pro Asp Asn Val Phe Ala Thr Met Glu His Met Leu Ser Gly Lys Arg 
                85                  90                  95      

Gly Met Met Leu Gly Asp Leu Ser Arg Val Val Arg Trp Ala Leu Leu 
            100                 105                 110         

Thr Thr Arg Thr Tyr Arg Thr His Pro Ile Asp Ser Asp Val Tyr Tyr 
        115                 120                 125             

Asp Leu Ile Trp Arg Phe Phe Phe Glu Lys Thr Leu Ala Pro Lys Glu 
    130                 135                 140                 

Leu Glu Asn Val Arg Gln Thr Gln Phe Val Ile Ser Gly Leu Ser His 
145                 150                 155                 160 

Ala Ile Gly Asn Ala Thr Leu Lys Arg Trp Gly Arg Pro Leu Arg Leu 
                165                 170                 175     

Asp Ala Arg Lys Trp Asp Val Val Leu Thr Phe Asn Val Ser Pro Ile 
            180                 185                 190         

Glu Phe Val Gly Arg Arg Ile Thr Arg Val His Asp Leu Ile Pro Leu 
        195                 200                 205             

Val Arg Pro Asp Phe Val Pro Ile Glu His Ala Glu Ile Phe Lys Ala 
    210                 215                 220                 

Gln Leu Glu Leu Thr Leu Arg Asn Ser Gln Ala Ile Val Thr Val Ser 
225                 230                 235                 240 

Lys Cys Ala Ala Gly Asp Leu Val Arg Leu Tyr Pro Asn Thr Gln Ser 
                245                 250                 255     

Lys Ile Glu Ile Ile Pro Cys Ala Thr Ser Arg Arg Tyr Tyr Arg Asp 
            260                 265                 270         

Leu Ser Ser Ile Pro Leu Gln Arg Ile Val Glu Arg Arg Leu Ser Glu 
        275                 280                 285             

Phe His Arg His Cys Arg Lys Arg Asp Arg Arg Leu Pro Gln Ile Thr 
    290                 295                 300                 

Pro Phe Lys Tyr Phe Ile Tyr His Gly Thr Ile Glu Pro Lys Lys Asn 
305                 310                 315                 320 

Val Lys Thr Leu Leu Leu Ala Phe Asp Ser Leu Val Asn Gln Glu Arg 
                325                 330                 335     

Phe Arg Glu Tyr Lys Leu Ile Ile Ala Gly Arg Phe Gly Trp Met Tyr 
            340                 345                 350         

Asp Gln Glu Arg Thr His Met Ala Lys Leu Ile Glu Lys Gly Ala Val 
        355                 360                 365             

Ile His Leu Glu Asp Thr Thr Asn Asp Glu Leu Arg Val Leu Leu Ser 
    370                 375                 380                 

Asn Ala Leu Ala His Val Phe Pro Ser Tyr Tyr Glu Gly Phe Gly Ile 
385                 390                 395                 400 

Pro Pro Val Glu Ala Leu Ser Cys Gly Cys Pro Thr Ile Val Ser Asn 
                405                 410                 415     

Val Ser Ser Leu Pro Glu Val Val Gly Arg Ala Gly Ile Leu Val Ser 
            420                 425                 430         

Pro Tyr Asp Ala Glu Trp Leu Ala Ser Glu Met Gly Ala Val Ala Leu 
        435                 440                 445             

Ala Pro Glu Ser Val Arg Glu Arg Ile Asp Arg Glu Ser Lys Tyr Val 
    450                 455                 460                 

Leu Glu Gln Tyr Ala Glu Ser Thr Val Arg Asp Lys Trp Met Arg Val 
465                 470                 475                 480 

Ile Glu Lys Ser Leu Ser Leu Gly Gly Arg Thr Ala Ser Thr Leu Met 
                485                 490                 495     

Ala Glu Asn Tyr Arg Val Asp Ser Val Leu 
            500                 505     

<210>   128
<211>   506
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 120

<400>   128
Met Val Ser Leu Thr Ile Ser Leu Leu Ala Asp Ile Tyr Glu Gly Arg 
                5                   10                  15      

His Gly Phe Ala Gly Ile Ser Thr Asp Met Arg Thr Thr Tyr Ala Gly 
            20                  25                  30          

Leu Ala Ser Thr Ala Asp Ile Ser Leu Thr Gly Leu Ile Tyr Ala Gln 
        35                  40                  45              

Arg Pro Leu Gly Asn Glu Ser Val Val Arg His Leu Leu Met Met Ser 
    50                  55                  60                  

Arg Pro Asp Leu Met Arg Leu Ala His Glu Ile Ala Gly His Arg Val 
65                  70                  75                  80  

Pro Asp Asn Val Phe Ala Thr Met Glu His Met Leu Ser Gly Lys Arg 
                85                  90                  95      

Gly Met Met Leu Gly Asp Leu Ser Arg Val Val Arg Trp Ala Leu Leu 
            100                 105                 110         

Thr Thr Arg Thr Tyr Arg Thr His Pro Ile Asp Ser Asp Val Tyr Tyr 
        115                 120                 125             

Asp Leu Ile Trp Arg Phe Phe Phe Glu Lys Thr Leu Ala Pro Lys Glu 
    130                 135                 140                 

Leu Glu Asn Val Arg Gln Thr Gln Phe Val Ile Ser Gly Leu Ser His 
145                 150                 155                 160 

Ala Ile Gly Asn Ala Thr Leu Lys Arg Trp Gly Arg Pro Leu Arg Leu 
                165                 170                 175     

Asp Ala Arg Lys Trp Asp Val Val Leu Thr Phe Asn Val Ser Pro Ile 
            180                 185                 190         

Glu Phe Val Gly Arg Arg Ile Thr Arg Val His Asp Leu Ile Pro Leu 
        195                 200                 205             

Val Arg Pro Asp Phe Val Pro Ile Glu His Ala Glu Ile Phe Lys Ala 
    210                 215                 220                 

Gln Leu Glu Leu Thr Leu Arg Asn Ser Gln Ala Ile Val Thr Val Ser 
225                 230                 235                 240 

Lys Cys Ala Ala Gly Asp Leu Val Arg Leu Tyr Pro Asn Thr Gln Ser 
                245                 250                 255     

Lys Ile Glu Ile Ile Pro Cys Ala Thr Ser Arg Arg Tyr Tyr Arg Asp 
            260                 265                 270         

Leu Ser Ser Ile Pro Leu Gln Arg Ile Val Glu Arg Arg Leu Ser Glu 
        275                 280                 285             

Phe His Arg His Cys Arg Lys Arg Asp Arg Arg Leu Pro Gln Ile Thr 
    290                 295                 300                 

Pro Phe Lys Tyr Phe Ile Tyr His Gly Thr Ile Glu Pro Lys Lys Asn 
305                 310                 315                 320 

Val Lys Thr Leu Leu Leu Ala Phe Asp Ser Leu Val Asn Gln Glu Arg 
                325                 330                 335     

Phe Arg Glu Tyr Lys Leu Ile Ile Ala Gly Arg Phe Gly Trp Met Tyr 
            340                 345                 350         

Asp Gln Glu Arg Thr His Met Ala Lys Leu Ile Glu Lys Gly Ala Val 
        355                 360                 365             

Ile His Leu Glu Asp Thr Thr Asn Asp Glu Leu Arg Val Leu Ile Ser 
    370                 375                 380                 

Asn Ala Leu Ala His Val Phe Pro Ser Tyr Tyr Glu Gly Phe Gly Ile 
385                 390                 395                 400 

Pro Pro Val Glu Ala Leu Ser Cys Gly Cys Pro Thr Ile Val Ser Asn 
                405                 410                 415     

Val Ser Ser Leu Pro Glu Val Val Gly Arg Ala Gly Ile Leu Val Ser 
            420                 425                 430         

Pro Tyr Asp Ala Glu Trp Leu Ala Ser Glu Met Gly Ala Val Ala Leu 
        435                 440                 445             

Ala Pro Glu Ser Val Arg Glu Arg Ile Glu Arg Glu Ser Lys Tyr Val 
    450                 455                 460                 

Leu Glu Gln Tyr Ala Glu Ser Thr Val Arg Asp Lys Trp Met Arg Val 
465                 470                 475                 480 

Ile Glu Lys Ser Leu Ser Leu Gly Gly Arg Thr Ala Ser Thr Leu Met 
                485                 490                 495     

Ala Glu Asn Tyr Arg Val Asp Ser Val Leu 
            500                 505     

<210>   129
<211>   506
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 120

<400>   129
Met Val Ser Leu Thr Ile Ser Leu Leu Ala Asp Ile Tyr Glu Gly Arg 
                5                   10                  15      

His Gly Phe Ala Gly Ile Ser Thr Asp Met Arg Thr Thr Tyr Ala Gly 
            20                  25                  30          

Leu Ala Ser Thr Ala Asp Ile Ser Leu Thr Gly Leu Ile Tyr Ala Gln 
        35                  40                  45              

Arg Pro Leu Gly Asn Glu Ser Val Val Arg His Leu Leu Met Met Ser 
    50                  55                  60                  

Arg Pro Asp Leu Met Arg Leu Ala His Glu Ile Ala Gly His Arg Val 
65                  70                  75                  80  

Pro Asp Asn Val Phe Ala Thr Met Glu His Met Leu Ser Gly Lys Arg 
                85                  90                  95      

Gly Met Met Leu Gly Asp Leu Ser Arg Val Val Arg Trp Ala Leu Leu 
            100                 105                 110         

Thr Thr Arg Thr Tyr Arg Thr His Pro Ile Asp Ser Asp Val Tyr Tyr 
        115                 120                 125             

Asp Leu Ile Trp Arg Phe Phe Phe Glu Lys Thr Leu Ala Pro Lys Glu 
    130                 135                 140                 

Leu Asp Asn Val Arg Gln Thr Gln Phe Val Ile Ser Gly Leu Ser His 
145                 150                 155                 160 

Ala Ile Gly Asn Ala Thr Leu Lys Arg Trp Gly Arg Pro Leu Arg Leu 
                165                 170                 175     

Asp Ala Arg Lys Trp Asp Val Val Leu Thr Phe Asn Val Ser Pro Ile 
            180                 185                 190         

Glu Phe Val Gly Arg Arg Ile Thr Arg Val His Asp Leu Ile Pro Leu 
        195                 200                 205             

Val Arg Pro Asp Phe Val Pro Ile Glu His Ala Glu Ile Phe Lys Ala 
    210                 215                 220                 

Gln Leu Glu Leu Thr Leu Arg Asn Ser Gln Ala Ile Val Thr Val Ser 
225                 230                 235                 240 

Lys Cys Ala Ala Gly Asp Leu Val Arg Leu Tyr Pro Asn Thr Gln Ser 
                245                 250                 255     

Lys Ile Glu Ile Ile Pro Cys Ala Thr Ser Arg Arg Tyr Tyr Arg Asp 
            260                 265                 270         

Leu Ser Ser Ile Pro Leu Gln Arg Ile Val Glu Arg Arg Leu Ser Glu 
        275                 280                 285             

Phe His Arg His Cys Arg Lys Arg Asp Arg Arg Leu Pro Gln Ile Thr 
    290                 295                 300                 

Pro Phe Lys Tyr Phe Ile Tyr His Gly Thr Ile Glu Pro Lys Lys Asn 
305                 310                 315                 320 

Val Lys Thr Leu Leu Leu Ala Phe Asp Ser Leu Val Asn Gln Glu Arg 
                325                 330                 335     

Phe Arg Glu Tyr Lys Leu Ile Ile Ala Gly Arg Phe Gly Trp Met Tyr 
            340                 345                 350         

Asp Gln Glu Arg Thr His Met Ala Lys Leu Ile Glu Lys Gly Ala Val 
        355                 360                 365             

Ile His Leu Glu Asp Thr Thr Asn Asp Glu Leu Arg Val Leu Leu Ser 
    370                 375                 380                 

Asn Ala Leu Ala His Val Phe Pro Ser Tyr Tyr Glu Gly Phe Gly Ile 
385                 390                 395                 400 

Pro Pro Val Glu Ala Leu Ser Cys Gly Cys Pro Thr Ile Val Ser Asn 
                405                 410                 415     

Val Ser Ser Leu Pro Glu Val Val Gly Arg Ala Gly Ile Leu Val Ser 
            420                 425                 430         

Pro Tyr Asp Ala Glu Trp Leu Ala Ser Glu Met Gly Ala Val Ala Leu 
        435                 440                 445             

Ala Pro Glu Ser Val Arg Glu Arg Ile Glu Arg Glu Ser Lys Tyr Val 
    450                 455                 460                 

Leu Glu Gln Tyr Ala Glu Ser Thr Val Arg Asp Lys Trp Met Arg Val 
465                 470                 475                 480 

Ile Glu Lys Ser Leu Ser Leu Gly Gly Arg Thr Ala Ser Thr Leu Met 
                485                 490                 495     

Ala Glu Asn Tyr Arg Val Asp Ser Val Leu 
            500                 505     

<210>   130
<211>   506
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 120

<400>   130
Met Val Ser Leu Thr Ile Ser Leu Leu Ala Asp Ile Tyr Glu Gly Arg 
                5                   10                  15      

His Gly Phe Ala Gly Ile Ser Thr Asp Met Arg Thr Thr Tyr Ala Gly 
            20                  25                  30          

Leu Ala Ser Thr Ala Asp Ile Ser Leu Thr Gly Leu Ile Tyr Ala Gln 
        35                  40                  45              

Arg Pro Leu Gly Asn Glu Ser Val Val Arg His Leu Leu Met Met Ser 
    50                  55                  60                  

Arg Pro Asp Leu Met Arg Leu Ala His Glu Ile Ala Gly His Arg Val 
65                  70                  75                  80  

Pro Asp Asn Val Phe Ala Thr Met Glu His Met Leu Ser Gly Lys Arg 
                85                  90                  95      

Gly Met Met Leu Gly Asp Leu Ser Arg Val Val Arg Trp Ala Leu Leu 
            100                 105                 110         

Thr Thr Arg Thr Tyr Arg Thr His Pro Ile Asp Ser Asp Val Tyr Tyr 
        115                 120                 125             

Asp Leu Ile Trp Arg Phe Phe Phe Glu Lys Thr Leu Ala Pro Lys Glu 
    130                 135                 140                 

Leu Glu Asn Val Arg Gln Thr Gln Phe Val Ile Ser Gly Leu Ser His 
145                 150                 155                 160 

Ala Ile Gly Asn Ala Thr Leu Lys Arg Trp Gly Arg Pro Leu Arg Leu 
                165                 170                 175     

Asp Ala Arg Lys Trp Asp Val Val Leu Thr Phe Asn Val Ser Pro Ile 
            180                 185                 190         

Glu Phe Val Gly Arg Arg Ile Thr Arg Val His Asp Leu Ile Pro Leu 
        195                 200                 205             

Val Arg Pro Asp Phe Val Pro Ile Glu His Ala Glu Ile Phe Lys Ala 
    210                 215                 220                 

Gln Leu Glu Leu Thr Leu Arg Asn Ser Gln Ala Ile Val Thr Val Ser 
225                 230                 235                 240 

Lys Cys Ala Ala Gly Asp Leu Val Arg Leu Tyr Pro Asn Thr Gln Ser 
                245                 250                 255     

Lys Ile Glu Ile Ile Pro Cys Ala Thr Ser Arg Arg Tyr Tyr Arg Asp 
            260                 265                 270         

Leu Ser Ser Ile Pro Leu Gln Arg Ile Val Glu Arg Arg Leu Ser Glu 
        275                 280                 285             

Phe His Arg His Cys Arg Lys Arg Asp Arg Arg Leu Pro Gln Ile Thr 
    290                 295                 300                 

Pro Phe Lys Tyr Phe Ile Tyr His Gly Thr Ile Glu Pro Lys Lys Asn 
305                 310                 315                 320 

Val Lys Thr Leu Leu Leu Ala Phe Asp Ser Leu Val Asn Gln Glu Arg 
                325                 330                 335     

Phe Arg Glu Tyr Lys Leu Ile Ile Ala Gly Arg Phe Gly Trp Met Tyr 
            340                 345                 350         

Asp Gln Glu Arg Thr His Met Ala Lys Leu Ile Glu Lys Gly Ala Val 
        355                 360                 365             

Ile His Leu Glu Asp Thr Thr Asn Glu Glu Leu Arg Val Leu Leu Ser 
    370                 375                 380                 

Asn Ala Leu Ala His Val Phe Pro Ser Tyr Tyr Glu Gly Phe Gly Ile 
385                 390                 395                 400 

Pro Pro Val Glu Ala Leu Ser Cys Gly Cys Pro Thr Ile Val Ser Asn 
                405                 410                 415     

Val Ser Ser Leu Pro Glu Val Val Gly Arg Ala Gly Ile Leu Val Ser 
            420                 425                 430         

Pro Tyr Asp Ala Glu Trp Leu Ala Ser Glu Met Gly Ala Val Ala Leu 
        435                 440                 445             

Ala Pro Glu Ser Val Arg Glu Arg Ile Glu Arg Glu Ser Lys Tyr Val 
    450                 455                 460                 

Leu Glu Gln Tyr Ala Glu Ser Thr Val Arg Asp Lys Trp Met Arg Val 
465                 470                 475                 480 

Ile Glu Lys Ser Leu Ser Leu Gly Gly Arg Thr Ala Ser Thr Leu Met 
                485                 490                 495     

Ala Glu Asn Tyr Arg Val Asp Ser Val Leu 
            500                 505     

<210>   131
<211>   506
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 120

<400>   131
Met Val Ser Leu Thr Ile Ser Leu Leu Ala Asp Ile Tyr Glu Gly Arg 
                5                   10                  15      

His Gly Phe Ala Gly Ile Ser Thr Asp Met Arg Thr Thr Tyr Ala Gly 
            20                  25                  30          

Leu Ala Ser Thr Ala Asp Ile Ser Leu Thr Gly Leu Ile Tyr Ala Gln 
        35                  40                  45              

Arg Pro Leu Gly Asn Glu Ser Val Val Arg His Leu Leu Met Met Ser 
    50                  55                  60                  

Arg Pro Asp Leu Met Arg Leu Ala His Glu Ile Ala Gly His Arg Val 
65                  70                  75                  80  

Pro Asp Asn Val Phe Ala Thr Met Glu His Met Leu Ser Gly Lys Arg 
                85                  90                  95      

Gly Met Met Leu Gly Asp Leu Ser Arg Val Val Arg Trp Ala Leu Leu 
            100                 105                 110         

Thr Thr Arg Thr Tyr Arg Thr His Pro Ile Asp Ser Asp Val Tyr Tyr 
        115                 120                 125             

Asp Leu Ile Trp Arg Phe Phe Phe Glu Lys Thr Leu Ala Pro Lys Glu 
    130                 135                 140                 

Leu Glu Asn Val Arg Gln Thr Gln Phe Val Ile Ser Gly Leu Ser His 
145                 150                 155                 160 

Ala Ile Gly Asn Ala Thr Leu Lys Arg Trp Gly Arg Pro Leu Arg Leu 
                165                 170                 175     

Asp Ala Arg Lys Trp Asp Val Val Leu Thr Phe Asn Val Ser Pro Ile 
            180                 185                 190         

Glu Phe Val Gly Arg Arg Ile Thr Arg Val His Asp Leu Ile Pro Leu 
        195                 200                 205             

Val Arg Pro Asp Phe Val Pro Ile Glu His Ala Glu Ile Phe Lys Ala 
    210                 215                 220                 

Gln Leu Glu Leu Thr Leu Arg Asn Ser Gln Ala Ile Val Thr Val Ser 
225                 230                 235                 240 

Lys Cys Ala Ala Gly Asp Leu Val Arg Leu Tyr Pro Asn Thr Gln Ser 
                245                 250                 255     

Lys Ile Glu Ile Ile Pro Cys Ala Thr Ser Arg Arg Tyr Tyr Arg Asp 
            260                 265                 270         

Leu Ser Ser Ile Pro Leu Gln Arg Ile Val Glu Arg Arg Leu Ser Glu 
        275                 280                 285             

Phe His Arg His Cys Arg Lys Arg Asp Arg Arg Leu Pro Gln Ile Thr 
    290                 295                 300                 

Pro Phe Lys Tyr Phe Ile Tyr His Gly Thr Ile Glu Pro Lys Lys Asn 
305                 310                 315                 320 

Val Lys Thr Leu Leu Leu Ala Phe Asp Ser Leu Val Asn Gln Glu Arg 
                325                 330                 335     

Phe Arg Glu Tyr Lys Leu Ile Ile Ala Gly Arg Phe Gly Trp Met Tyr 
            340                 345                 350         

Asp Gln Glu Arg Thr His Met Ala Lys Leu Ile Glu Lys Gly Ala Val 
        355                 360                 365             

Ile His Leu Glu Asp Thr Thr Asn Asp Glu Leu Arg Val Leu Leu Ser 
    370                 375                 380                 

Asn Ala Leu Ala His Val Phe Pro Ser Tyr Tyr Glu Gly Phe Gly Ile 
385                 390                 395                 400 

Pro Pro Val Glu Ala Leu Ser Cys Gly Cys Pro Thr Ile Val Ser Asn 
                405                 410                 415     

Val Ser Ser Leu Pro Glu Val Val Gly Arg Ala Gly Ile Leu Val Ser 
            420                 425                 430         

Pro Tyr Asp Ala Glu Trp Leu Ala Ser Glu Met Gly Ala Val Ala Leu 
        435                 440                 445             

Ala Pro Glu Ser Val Arg Glu Arg Ile Glu Lys Glu Ser Lys Tyr Val 
    450                 455                 460                 

Leu Glu Gln Tyr Ala Glu Ser Thr Val Arg Asp Lys Trp Met Arg Val 
465                 470                 475                 480 

Ile Glu Lys Ser Leu Ser Leu Gly Gly Arg Thr Ala Ser Thr Leu Met 
                485                 490                 495     

Ala Glu Asn Tyr Arg Val Asp Ser Val Leu 
            500                 505     

<210>   132
<211>   1521
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 121

<400>   132
gtggtttcgt tgacgatttc gttgctcgcg gatatctatg aaggacgaca tgggttcgcc       60

ggtatttcga cagacatgag aacgacgtat gctggcctgg cgtcgactgc cgacatatcg      120

ctcacgggac tcatttatgc tcagcgtccc ttgggcaacg aatcggtcgt gcggcatctt      180

ctgatgatgt ctcgccccga tttgatgcga ctcgctcacg aaatcgcagg gcatcgagtt      240

cccgataacg tcttcgcaac gatggagcac atgttgtctg gaaaacgagg tatgatgctg      300

ggcgacctgt cgcgtgtcgt taggtgggca cttttaacaa cgaggactta ccgtacccat      360

ccgatcgaca gtgacgttta ttatgacttg atatggcggt tcttttttga gaagacactg      420

gcgccaaagg aactcgagaa tgtacgccag acgcagtttg tgatatctgg cttgtctcac      480

gcaattggca acgcaacgct gaaaagatgg ggccgacctc ttcgattgga tgctagaaaa      540

tgggatgtgg ttcttacctt taacgtgtca cccatcgaat ttgtcggaag acggatcact      600

cgcgtgcatg acctcatacc attggttcgt ccggattttg tgcctattga gcatgctgag      660

atcttcaagg cacaactcga gttgacgctg aggaattcgc aggccattgt cacggtgtca      720

aagtgtgctg ccggcgatct ggtgcgttta tatccaaata cgcagtccaa aattgaaatc      780

atcccatgcg cgacgtctcg acgatattat cgtgatttat catcgattcc tctgcagcgt      840

attgtcgagc gaaggttgtc ggagtttcac aggcattgtc gcaagcgcga tcgccgatta      900

ccgcagatta cgccgttcaa atattttata tatcacggga cgatcgagcc gaagaaaaat      960

gtcaaaacgc ttctgctagc ctttgactct ttggtaaatc aagagcggtt tagagagtat     1020

aagctcatca ttgcaggaag atttggttgg atgtatgacc aagagcgtac gcatatggcg     1080

aaattgatcg agaaaggtgc cgtcattcat ctcgaggata caacgaacga tgaactcagg     1140

gttcttttaa gcaacgcatt ggctcatgtg tttccgtctt attacgaagg ttttggtata     1200

ccgcctgttg aggctttgtc gtgtgggtgt cccactattg tttcgaatgt ttcttctcta     1260

ccggaggttg tagggcgagc cgggatcctc gtcagtccgt atgatgcaga atggttggcc     1320

tcggaaatgg gggctgtggc gctggctcca gaatcagtac gagagcggat cgatcgagaa     1380

tccaaatatg tgttggaaca gtacgccgaa tcgactgttc gggacaagtg gatgagggta     1440

attgaaaagt cgcttagttt gggtgggcgt acagcctcaa cgctgatggc ggagaattac     1500

cgggtcgact cagtgctgta g                                               1521


<210>   133
<211>   1521
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 121

<400>   133
gtggtttcgt tgacgatttc gttgctcgcg gatatctatg aaggacgaca tgggttcgcc       60

ggtatttcga cagacatgag aacgacgtat gctggcctgg cgtcgactgc cgacatatcg      120

ctcacgggac tcatttatgc tcagcgtccc ttgggcaacg aatcggtcgt gcggcatctt      180

ctgatgatgt ctcgccccga tttgatgcga ctcgctcacg aaatcgcagg gcatcgagtt      240

cccgataacg tcttcgcaac gatggagcac atgttgtctg gaaaacgagg tatgatgctg      300

ggcgacctgt cgcgtgtcgt taggtgggca cttttaacaa cgaggactta ccgtacccat      360

ccgatcgaca gtgacgttta ttatgacttg atatggcggt tcttttttga gaagacactg      420

gcgccaaagg aactcgagaa tgtacgccag acgcagtttg tgatatctgg cttgtctcac      480

gcaattggca acgcaacgct gaaaagatgg ggccgacctc ttcgattgga tgctagaaaa      540

tgggatgtgg ttcttacctt taacgtgtca cccatcgaat ttgtcggaag acggatcact      600

cgcgtgcatg acctcatacc attggttcgt ccggattttg tgcctattga gcatgctgag      660

atcttcaagg cacaactcga gttgacgctg aggaattcgc aggccattgt cacggtgtca      720

aagtgtgctg ccggcgatct ggtgcgttta tatccaaata cgcagtccaa aattgaaatc      780

atcccatgcg cgacgtctcg acgatattat cgtgatttat catcgattcc tctgcagcgt      840

attgtcgagc gaaggttgtc ggagtttcac aggcattgtc gcaagcgcga tcgccgatta      900

ccgcagatta cgccgttcaa atattttata tatcacggga cgatcgagcc gaagaaaaat      960

gtcaaaacgc ttctgctagc ctttgactct ttggtaaatc aagagcggtt tagagagtat     1020

aagctcatca ttgcaggaag atttggttgg atgtatgacc aagagcgtac gcatatggcg     1080

aaattgatcg agaaaggtgc cgtcattcat ctcgaggata caacgaacga tgaactcagg     1140

gttcttatta gcaacgcatt ggctcatgtg tttccgtctt attacgaagg ttttggtata     1200

ccgcctgttg aggctttgtc gtgtgggtgt cccactattg tttcgaatgt ttcttctcta     1260

ccggaggttg tagggcgagc cgggatcctc gtcagtccgt atgatgcaga atggttggcc     1320

tcggaaatgg gggctgtggc gctggctcca gaatcagtac gagagcggat cgaacgagaa     1380

tccaaatatg tgttggaaca gtacgccgaa tcgactgttc gggacaagtg gatgagggta     1440

attgaaaagt cgcttagttt gggtgggcgt acagcctcaa cgctgatggc ggagaattac     1500

cgggtcgact cagtgctgta g                                               1521


<210>   134
<211>   1521
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 121

<400>   134
gtggtttcgt tgacgatttc gttgctcgcg gatatctatg aaggacgaca tgggttcgcc       60

ggtatttcga cagacatgag aacgacgtat gctggcctgg cgtcgactgc cgacatatcg      120

ctcacgggac tcatttatgc tcagcgtccc ttgggcaacg aatcggtcgt gcggcatctt      180

ctgatgatgt ctcgccccga tttgatgcga ctcgctcacg aaatcgcagg gcatcgagtt      240

cccgataacg tcttcgcaac gatggagcac atgttgtctg gaaaacgagg tatgatgctg      300

ggcgacctgt cgcgtgtcgt taggtgggca cttttaacaa cgaggactta ccgtacccat      360

ccgatcgaca gtgacgttta ttatgacttg atatggcggt tcttttttga gaagacactg      420

gcgccaaagg aactcgataa tgtacgccag acgcagtttg tgatatctgg cttgtctcac      480

gcaattggca acgcaacgct gaaaagatgg ggccgacctc ttcgattgga tgctagaaaa      540

tgggatgtgg ttcttacctt taacgtgtca cccatcgaat ttgtcggaag acggatcact      600

cgcgtgcatg acctcatacc attggttcgt ccggattttg tgcctattga gcatgctgag      660

atcttcaagg cacaactcga gttgacgctg aggaattcgc aggccattgt cacggtgtca      720

aagtgtgctg ccggcgatct ggtgcgttta tatccaaata cgcagtccaa aattgaaatc      780

atcccatgcg cgacgtctcg acgatattat cgtgatttat catcgattcc tctgcagcgt      840

attgtcgagc gaaggttgtc ggagtttcac aggcattgtc gcaagcgcga tcgccgatta      900

ccgcagatta cgccgttcaa atattttata tatcacggga cgatcgagcc gaagaaaaat      960

gtcaaaacgc ttctgctagc ctttgactct ttggtaaatc aagagcggtt tagagagtat     1020

aagctcatca ttgcaggaag atttggttgg atgtatgacc aagagcgtac gcatatggcg     1080

aaattgatcg agaaaggtgc cgtcattcat ctcgaggata caacgaacga tgaactcagg     1140

gttcttttaa gcaacgcatt ggctcatgtg tttccgtctt attacgaagg ttttggtata     1200

ccgcctgttg aggctttgtc gtgtgggtgt cccactattg tttcgaatgt ttcttctcta     1260

ccggaggttg tagggcgagc cgggatcctc gtcagtccgt atgatgcaga atggttggcc     1320

tcggaaatgg gggctgtggc gctggctcca gaatcagtac gagagcggat cgaacgagaa     1380

tccaaatatg tgttggaaca gtacgccgaa tcgactgttc gggacaagtg gatgagggta     1440

attgaaaagt cgcttagttt gggtgggcgt acagcctcaa cgctgatggc ggagaattac     1500

cgggtcgact cagtgctgta g                                               1521


<210>   135
<211>   1521
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 121

<400>   135
gtggtttcgt tgacgatttc gttgctcgcg gatatctatg aaggacgaca tgggttcgcc       60

ggtatttcga cagacatgag aacgacgtat gctggcctgg cgtcgactgc cgacatatcg      120

ctcacgggac tcatttatgc tcagcgtccc ttgggcaacg aatcggtcgt gcggcatctt      180

ctgatgatgt ctcgccccga tttgatgcga ctcgctcacg aaatcgcagg gcatcgagtt      240

cccgataacg tcttcgcaac gatggagcac atgttgtctg gaaaacgagg tatgatgctg      300

ggcgacctgt cgcgtgtcgt taggtgggca cttttaacaa cgaggactta ccgtacccat      360

ccgatcgaca gtgacgttta ttatgacttg atatggcggt tcttttttga gaagacactg      420

gcgccaaagg aactcgagaa tgtacgccag acgcagtttg tgatatctgg cttgtctcac      480

gcaattggca acgcaacgct gaaaagatgg ggccgacctc ttcgattgga tgctagaaaa      540

tgggatgtgg ttcttacctt taacgtgtca cccatcgaat ttgtcggaag acggatcact      600

cgcgtgcatg acctcatacc attggttcgt ccggattttg tgcctattga gcatgctgag      660

atcttcaagg cacaactcga gttgacgctg aggaattcgc aggccattgt cacggtgtca      720

aagtgtgctg ccggcgatct ggtgcgttta tatccaaata cgcagtccaa aattgaaatc      780

atcccatgcg cgacgtctcg acgatattat cgtgatttat catcgattcc tctgcagcgt      840

attgtcgagc gaaggttgtc ggagtttcac aggcattgtc gcaagcgcga tcgccgatta      900

ccgcagatta cgccgttcaa atattttata tatcacggga cgatcgagcc gaagaaaaat      960

gtcaaaacgc ttctgctagc ctttgactct ttggtaaatc aagagcggtt tagagagtat     1020

aagctcatca ttgcaggaag atttggttgg atgtatgacc aagagcgtac gcatatggcg     1080

aaattgatcg agaaaggtgc cgtcattcat ctcgaggata caacgaacga agaactcagg     1140

gttcttttaa gcaacgcatt ggctcatgtg tttccgtctt attacgaagg ttttggtata     1200

ccgcctgttg aggctttgtc gtgtgggtgt cccactattg tttcgaatgt ttcttctcta     1260

ccggaggttg tagggcgagc cgggatcctc gtcagtccgt atgatgcaga atggttggcc     1320

tcggaaatgg gggctgtggc gctggctcca gaatcagtac gagagcggat cgaacgagaa     1380

tccaaatatg tgttggaaca gtacgccgaa tcgactgttc gggacaagtg gatgagggta     1440

attgaaaagt cgcttagttt gggtgggcgt acagcctcaa cgctgatggc ggagaattac     1500

cgggtcgact cagtgctgta g                                               1521


<210>   136
<211>   1521
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 121

<400>   136
gtggtttcgt tgacgatttc gttgctcgcg gatatctatg aaggacgaca tgggttcgcc       60

ggtatttcga cagacatgag aacgacgtat gctggcctgg cgtcgactgc cgacatatcg      120

ctcacgggac tcatttatgc tcagcgtccc ttgggcaacg aatcggtcgt gcggcatctt      180

ctgatgatgt ctcgccccga tttgatgcga ctcgctcacg aaatcgcagg gcatcgagtt      240

cccgataacg tcttcgcaac gatggagcac atgttgtctg gaaaacgagg tatgatgctg      300

ggcgacctgt cgcgtgtcgt taggtgggca cttttaacaa cgaggactta ccgtacccat      360

ccgatcgaca gtgacgttta ttatgacttg atatggcggt tcttttttga gaagacactg      420

gcgccaaagg aactcgagaa tgtacgccag acgcagtttg tgatatctgg cttgtctcac      480

gcaattggca acgcaacgct gaaaagatgg ggccgacctc ttcgattgga tgctagaaaa      540

tgggatgtgg ttcttacctt taacgtgtca cccatcgaat ttgtcggaag acggatcact      600

cgcgtgcatg acctcatacc attggttcgt ccggattttg tgcctattga gcatgctgag      660

atcttcaagg cacaactcga gttgacgctg aggaattcgc aggccattgt cacggtgtca      720

aagtgtgctg ccggcgatct ggtgcgttta tatccaaata cgcagtccaa aattgaaatc      780

atcccatgcg cgacgtctcg acgatattat cgtgatttat catcgattcc tctgcagcgt      840

attgtcgagc gaaggttgtc ggagtttcac aggcattgtc gcaagcgcga tcgccgatta      900

ccgcagatta cgccgttcaa atattttata tatcacggga cgatcgagcc gaagaaaaat      960

gtcaaaacgc ttctgctagc ctttgactct ttggtaaatc aagagcggtt tagagagtat     1020

aagctcatca ttgcaggaag atttggttgg atgtatgacc aagagcgtac gcatatggcg     1080

aaattgatcg agaaaggtgc cgtcattcat ctcgaggata caacgaacga tgaactcagg     1140

gttcttttaa gcaacgcatt ggctcatgtg tttccgtctt attacgaagg ttttggtata     1200

ccgcctgttg aggctttgtc gtgtgggtgt cccactattg tttcgaatgt ttcttctcta     1260

ccggaggttg tagggcgagc cgggatcctc gtcagtccgt atgatgcaga atggttggcc     1320

tcggaaatgg gggctgtggc gctggctcca gaatcagtac gagagcggat cgaaaaagaa     1380

tccaaatatg tgttggaaca gtacgccgaa tcgactgttc gggacaagtg gatgagggta     1440

attgaaaagt cgcttagttt gggtgggcgt acagcctcaa cgctgatggc ggagaattac     1500

cgggtcgact cagtgctgta g                                               1521


<210>   137
<211>   397
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   137
Met Phe Ser Asn Phe Val Trp Ser Trp Leu Ala His Ala Leu Pro Arg 
                5                   10                  15      

Ala Ala Trp Leu Pro Val Leu Cys Ala Val Val Trp Thr Ala Ile Phe 
            20                  25                  30          

Leu Arg Thr Ile Pro Asp Leu Val Arg Thr Pro Arg Leu Arg Pro Arg 
        35                  40                  45              

Glu Ala Ala Arg Ala Ser Pro Pro Ser Tyr Gly Arg Val Ser Val Val 
    50                  55                  60                  

Val Ala Ala Arg Asp Glu Arg Glu His Ile Glu Val Thr Leu Glu Ser 
65                  70                  75                  80  

Leu Leu Arg Gln Thr Tyr Pro Asp Leu Glu Ile Val Ala Val Asp Asp 
                85                  90                  95      

Arg Ser Thr Asp Gly Thr Gly Asp Val Ile Asp Arg Met Ala Ala Ser 
            100                 105                 110         

Asp Ser Arg Ile Val Pro Val His Ile Arg Glu Leu Pro Arg Gly Trp 
        115                 120                 125             

Leu Gly Lys Asn His Ala Leu Tyr Ala Gly Ala Met Arg Ala Thr Gly 
    130                 135                 140                 

Asp Trp Leu Leu Phe Ala Asp Ala Asp Val Arg Phe Tyr Pro Asp Ala 
145                 150                 155                 160 

Val Glu Arg Ala Met Ala Tyr Val His Ala His Arg Leu His His Leu 
                165                 170                 175     

Thr Val Ala Pro Arg Leu Ile Ala Ser Gly Tyr Ala Leu Lys Leu Leu 
            180                 185                 190         

Thr Ala Met Tyr Ile Phe Asn Tyr Val Leu Phe Lys Arg Pro Gln Ser 
        195                 200                 205             

Ala Tyr Arg Arg Arg Thr Arg Ala His Ala Gly Ile Gly Ala Phe Asn 
    210                 215                 220                 

Leu Val Ser Arg Glu Ala Tyr Glu Arg Ile Gly Thr His Arg Ala Ile 
225                 230                 235                 240 

Ser Leu Arg Pro Asp Asp Asp Leu His Leu Gly Lys Leu Ile Lys Arg 
                245                 250                 255     

His Gly Phe Arg Gln Arg Phe Val Val Ala Gln Asp Met Ile Glu Ile 
            260                 265                 270         

Glu Trp Tyr Pro Ser Phe Arg Ala Met Val Val Gly Met Glu Lys Ala 
        275                 280                 285             

Pro Leu Pro Ala Phe His Tyr Ser Ala Val Leu Leu Thr Ala Ala Met 
    290                 295                 300                 

Met Val Met Met Val Leu Tyr Thr Thr Pro Phe Ala Gly Ala Ile Phe 
305                 310                 315                 320 

Gly Pro Gly Trp Tyr Arg Leu Val Tyr Leu Tyr Cys Leu Val Leu Met 
                325                 330                 335     

Gly Ile Leu Tyr Glu Leu His Ala Val Phe Leu Arg Leu Pro Lys His 
            340                 345                 350         

Gln Phe Leu Ile Leu Pro Leu Gly Met Leu Leu Tyr Ser Tyr Ala Phe 
        355                 360                 365             

Ile Arg Ser Ala Val Leu Ala Val Arg Arg Gly Gly Leu Val Trp Arg 
    370                 375                 380                 

Asp Thr Phe Tyr Thr Leu Arg Glu Leu Arg Arg Gly Leu 
385                 390                 395         

<210>   138
<211>   1194
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   138
atgttctcca acttcgtgtg gtcctggctt gcgcacgcgc ttccgcgggc ggcgtggctg       60

cccgtcctgt gcgcggtggt gtggacggcc atctttctcc gcaccatccc ggacctcgtg      120

cgaacgccgc gccttcggcc ccgtgaggcg gcgagagcga gcccaccgtc ctatggccgc      180

gtgagcgtcg tggtggcggc gcgcgatgag cgggagcaca tcgaggtcac gctcgaatcg      240

ctgctgcgcc agacgtatcc ggatctcgaa atcgtcgcgg ttgacgatcg gtcgacggac      300

gggacgggcg acgtgatcga ccggatggcg gccagcgatt cgcgcattgt gccggtgcac      360

atccgagagc tgccgcgtgg atggctgggc aagaaccacg ccctgtatgc aggcgctatg      420

cgcgcgacgg gcgattggct gctgtttgcg gacgcggacg tgcggtttta cccggacgcg      480

gtggaacggg ccatggccta cgtgcacgcg catcggctgc atcacctgac cgtggcgccg      540

aggctcatcg catccggcta cgcgctgaag ctattgacgg ccatgtacat cttcaactat      600

gtgctgttca agcggcccca gagcgcgtac cgcaggcgca ctcgcgcaca cgccggcatc      660

ggcgcgttca acctcgtcag ccgcgaggcg tacgagcgca tcggcacgca tcgagccatc      720

agcttacgtc ccgacgacga tctccacctc ggcaagctca tcaagcggca tggatttcgg      780

cagcgattcg tcgtggcgca ggacatgatc gagatcgagt ggtatccgag cttccgcgcg      840

atggtcgtcg gcatggagaa agcgccgctg ccggcatttc actattccgc ggtgcttttg      900

acggcggcca tgatggtgat gatggtgctc tacacgacgc ctttcgcagg ggccatcttc      960

ggaccgggtt ggtatcgatt ggtttatctg tattgtctcg tcctcatggg aatcttatat     1020

gaacttcatg cggtgttttt gagactgccc aagcaccagt tcctcatcct gccgctcggc     1080

atgctgctgt acagctacgc cttcattcgt tcggccgtgc tggcggttcg ccgaggaggg     1140

ctcgtgtggc gggacacgtt ttacacgctg cgcgaactgc gccgaggtct gtga           1194


<210>   139
<211>   377
<212>   PRT
<213>   Bacillus selenitireducens MLS10

<400>   139
Ala Trp Ile Thr Val Ile Leu Trp Gly Leu Val Leu Ile Asp Thr Trp 
                5                   10                  15      

Ile Gly Phe Arg Arg Phe Pro Lys Leu Asp Ser Phe Arg Glu Thr Val 
            20                  25                  30          

Leu Ser Pro Ala Asp Arg Ser Gly Arg Val Ser Val Ile Val Ala Ala 
        35                  40                  45              

Arg Asn Glu Glu Asp Ala Ile Tyr Glu Ser Val Lys Ser Gln Leu Thr 
    50                  55                  60                  

Ser Thr Trp Pro Gly Val Glu Trp Ile Leu Val Asn Asp Arg Ser Thr 
65                  70                  75                  80  

Asp Ala Thr Gly Glu Lys Met Asp Glu Leu Ala Arg Gln Asp Ser Arg 
                85                  90                  95      

Ile Arg Val Val His Val Arg Asp Leu Pro Glu Gly Trp Leu Gly Lys 
            100                 105                 110         

Asn His Ala Met His Cys Gly Tyr Glu Glu Ala Thr Gly Ser Ala Leu 
        115                 120                 125             

Leu Phe Thr Asp Ala Asp Val Met Phe Arg Pro His Thr Ile Glu Gly 
    130                 135                 140                 

Ala Met Ala Cys Lys Lys Thr Thr Gly Ala Arg His Val Thr Met Thr 
145                 150                 155                 160 

Pro Glu Met Thr Val Lys Thr Phe Trp Thr Gln Ala Phe Val His Phe 
                165                 170                 175     

Phe Leu Phe Gly Phe Ser Tyr Tyr Lys Arg Pro Trp Lys Ala Asn Asp 
            180                 185                 190         

Asp Arg Ser Lys Ile Ala Leu Gly Ile Gly Ala Phe Asn Leu Ile Asp 
        195                 200                 205             

Arg Glu Ala Tyr Glu Ala Ile Gly Thr His Arg Ala Ile Arg Leu Arg 
    210                 215                 220                 

Pro Asp Asp Asp Leu Met Leu Gly Val Arg Val Lys Ala Ala Gly Met 
225                 230                 235                 240 

Arg Gln Arg Ala Ile Asp Gly Thr Gly Gly Leu Ser Val Glu Trp Tyr 
                245                 250                 255     

Pro Ser Leu Lys Glu Ala Val Lys Gly Leu Glu Lys Asn Thr Phe Ala 
            260                 265                 270         

Gly Leu His Tyr Ser Trp Leu Met Val Leu Phe Ala Leu Ser Gly Val 
        275                 280                 285             

Phe Val Ser Gln Val Leu Pro Phe Ile Gly Val Leu Phe His Glu Gly 
    290                 295                 300                 

Ser Ala Arg Trp Val Tyr Leu Ala Ala Val Val Leu Met Leu Ile Ile 
305                 310                 315                 320 

Tyr Val Lys Thr Ser Phe Ala Pro Trp Lys Lys Ala Leu Lys Thr Phe 
                325                 330                 335     

Thr Val Phe Pro Leu Ser Ala Leu Ile Phe Ile Tyr Thr Leu Ile Arg 
            340                 345                 350         

Ala Val Leu Lys Thr Val Ile Arg Gly Gly Ile Glu Trp Arg Gly Thr 
        355                 360                 365             

Phe Tyr Ser Leu Lys Glu Leu Lys Lys 
    370                 375         

<210>   140
<211>   375
<212>   PRT
<213>   Bacillus sp. NRRL B-14911

<400>   140
Ala Ile Leu Leu Ala Leu Cys Met Ile Ile Trp Ile Cys Ala Ile Ala 
                5                   10                  15      

Asp Ala Phe Leu Gly Leu Arg Arg Leu Asp Gln Leu Glu Glu Glu Glu 
            20                  25                  30          

Glu Leu Ala Ser Gly Pro Leu Leu Ser Ile Val Thr Ala Ala Arg Asn 
        35                  40                  45              

Glu Ala Ala Val Ile Glu Glu Ser Ile Arg Thr Gln Leu Ser Gln Asn 
    50                  55                  60                  

Tyr Thr His Leu Glu Trp Ile Leu Val Asn Asp Arg Ser Glu Asp Gly 
65                  70                  75                  80  

Thr Gly Glu Ile Met Glu Arg Leu Ala Gln Glu Asp Ala Arg Ile Arg 
                85                  90                  95      

Val Leu His Ile His Asp Leu Pro Asp Gly Trp Leu Gly Lys Asn His 
            100                 105                 110         

Ala Leu Cys Arg Gly Ala Gly Met Ala Lys Gly Asp Ile Ile Leu Phe 
        115                 120                 125             

Thr Asp Ala Asp Val Met Phe Arg Lys Asp Ala Ile Gly Arg Ala Leu 
    130                 135                 140                 

Ser Tyr Phe Arg Arg Gln Gly Leu Asp His Leu Thr Ala Ala Pro Ala 
145                 150                 155                 160 

Leu Lys Ala His Ser Phe Trp Leu Lys Ala Phe Ile Gly Phe Phe Leu 
                165                 170                 175     

Phe Gly Phe Ser Tyr Tyr Lys Arg Pro Trp Gln Ala Asn Arg Pro Gln 
            180                 185                 190         

Ser Lys Thr Gly Ile Gly Ile Gly Ala Phe Asn Leu Ile Ser Lys Lys 
        195                 200                 205             

Ala Tyr Glu Asp Ala Gly Thr His Glu Ser Ile Arg Met Arg Pro Asp 
    210                 215                 220                 

Asp Asp Leu Met Leu Gly Met Leu Met Lys Arg Leu Gly Tyr Arg Gln 
225                 230                 235                 240 

Lys Ile Ala Ala Ala Leu Glu Leu Leu Glu Val Glu Trp Tyr Thr Ser 
                245                 250                 255     

Leu Gly Glu Ala Phe Arg Gly Leu Glu Lys Asn Thr Phe Ala Gly Leu 
            260                 265                 270         

His Tyr Arg Ile Ser Met Val Leu Leu Ala Ile Ala Gly Thr Phe Ile 
        275                 280                 285             

Ser Gln Val Val Pro Phe Phe Ala Val Phe Ser Pro Asp Arg Leu Val 
    290                 295                 300                 

Met Gly Leu Ser Ala Ala Asn Ile Ile Leu Leu Gly Gly Leu Tyr Thr 
305                 310                 315                 320 

Met Ile Ser Asn Arg Met Thr Pro Phe Ser Ser Ala Leu Phe Leu Val 
                325                 330                 335     

Phe Pro Leu Thr Ala Leu Leu Phe Ile Tyr Ser Ile Met Arg Ala Ser 
            340                 345                 350         

Phe Leu Thr Phe Lys Arg Gly Gly Ile Val Trp Arg Gly Thr Lys Tyr 
        355                 360                 365             

Ser Leu Lys Glu Leu Arg Arg 
    370                 375 

<210>   141
<211>   347
<212>   PRT
<213>   Symbiobacterium thermophilum IAM 14863

<400>   141
Pro Asn Ala Ser Leu Gly Pro Asn Pro Pro Pro Arg Val Ser Ala Ile 
                5                   10                  15      

Val Pro Ala Cys Asn Glu Ala Arg Ser Ile Glu Ser Ala Val Arg Ser 
            20                  25                  30          

Leu Ile Arg Gln Asp Tyr Pro Asn Leu Glu Val Val Leu Val Asn Asp 
        35                  40                  45              

Arg Ser Thr Asp Gly Thr Gly Ala Ile Met Asp Arg Leu Ala Arg Glu 
    50                  55                  60                  

Phe Pro Gln Val Thr Val Val His Ile Asp Arg Leu Pro Ala Gly Trp 
65                  70                  75                  80  

Leu Gly Lys Asn His Ala Leu Trp Val Gly Ala Arg His Ala Ser Gly 
                85                  90                  95      

Glu Ile Leu Leu Phe Thr Asp Ala Asp Val His Tyr Asp Pro Thr Thr 
            100                 105                 110         

Val Arg Arg Ala Val Ala Phe Met Glu Gln Arg Arg Leu Asp His Leu 
        115                 120                 125             

Thr Leu Ala Pro Asp Leu Thr Val Arg Gly Tyr Trp Leu Glu Ala Trp 
    130                 135                 140                 

Val Gly Phe Phe Val Met Ala Phe Leu Ala Tyr Lys Thr Pro Tyr Arg 
145                 150                 155                 160 

Ala Asn Asp Pro Arg Ser Lys Val Gly Thr Gly Ile Gly Ala Phe Asn 
                165                 170                 175     

Met Ile Arg Arg Thr Ala Tyr Glu Ala Ile Gly Thr His Arg Ala Ile 
            180                 185                 190         

Ser Leu Arg Pro Asp Asp Asp Leu Arg Leu Gly Gln Arg Leu Lys Arg 
        195                 200                 205             

Met Gly His Ser Ser His Val Ala Met Gly Arg Gly Leu Val Ser Val 
    210                 215                 220                 

Glu Trp Tyr Thr Ser Leu Arg Glu Ala Ile Arg Gly Leu Glu Lys Asn 
225                 230                 235                 240 

Ala Phe Ala Gly Leu Glu Tyr Asn Leu Gly Thr Val Phe Ala Ser Val 
                245                 250                 255     

Val Gly Ile Leu Ala Ile Met Val Trp Pro Tyr Val Ala Leu Phe Leu 
            260                 265                 270         

Thr Glu Gly Trp Thr Leu Gly Leu Tyr Ala Gly Ala Ile Leu Leu Gln 
        275                 280                 285             

Leu Ala Leu Tyr Val Leu Ala Asn Gly Ala Gly Gly Pro Arg Met Cys 
    290                 295                 300                 

Gln Leu Ala Leu Ala Tyr Pro Val Ala Ala Leu Leu Phe Ala Tyr Ala 
305                 310                 315                 320 

Ile Ala Arg Ala Thr Tyr Leu Thr Leu Arg Arg Gly Gly Ile Ala Trp 
                325                 330                 335     

Arg Gly Thr Phe Tyr Pro Leu Ala Leu Leu Arg 
            340                 345         

<210>   142
<211>   392
<212>   PRT
<213>   Acidobacteria bacterium Ellin345

<400>   142
Ile Trp Trp His Ala His Trp Glu Ala Leu Val Ala Phe Ala Ile Gly 
                5                   10                  15      

Leu Val Trp Leu Ser Arg Leu Leu Ala Ala Ser Arg Gly Met Pro Lys 
            20                  25                  30          

Leu Ala Glu Ile Ser Arg Pro Glu Trp Asp Leu Arg Pro Asp Pro Ala 
        35                  40                  45              

Pro Arg Val Ser Ile Val Val Cys Ala Leu Asn Glu Glu Gly Lys Ile 
    50                  55                  60                  

Glu Pro Ala Leu Arg Ser Leu Leu Glu Leu Asp Tyr Pro Asp Tyr Glu 
65                  70                  75                  80  

Val Val Ala Val Asp Asp Arg Ser Thr Asp Arg Thr Gly Glu Ile Met 
                85                  90                  95      

Asp Arg Ile Ala Glu Glu Tyr Arg Ala Asn Ala His His His Leu Arg 
            100                 105                 110         

Val Val His Val Thr Glu Leu Pro Pro Gly Trp Leu Gly Lys Val His 
        115                 120                 125             

Ala Met Trp Ser Ala Thr Arg Val Ala Asp Gly Asp Trp Ile Leu Phe 
    130                 135                 140                 

Thr Asp Ala Asp Val Val Phe Gln Lys Glu Thr Leu Arg Arg Ala Ile 
145                 150                 155                 160 

Ala Tyr Ala Glu Arg Glu Arg Ala Asp His Val Val Leu Phe Pro Thr 
                165                 170                 175     

Met Leu Met Tyr Thr Trp Asp Glu Arg Met Met Ile Ala Phe Phe Gln 
            180                 185                 190         

Ala Met Phe Val Phe Gly His Arg Pro Trp Lys Thr Ala Asp Pro Lys 
        195                 200                 205             

Ser Arg Asp His Met Gly Val Gly Ala Phe Asn Leu Ile Arg Arg Ser 
    210                 215                 220                 

Val Tyr Glu Lys Ile Gly Thr Tyr Ala Arg Met Lys Met Ala Val Val 
225                 230                 235                 240 

Asp Asp Met Lys Leu Gly Glu Ile Val Lys Lys Glu Gly Tyr Ala Gln 
                245                 250                 255     

Arg Asn Val Phe Gly Arg Asp Leu Ile Gln Leu His Trp His Ser Gly 
            260                 265                 270         

Ala Leu Gly Val Val Arg Gly Leu Thr Lys Asn Phe Phe Ala Ile Leu 
        275                 280                 285             

Arg Phe Asn Pro Phe Leu Thr Leu Gly Val Ile Leu Gly Met Leu Leu 
    290                 295                 300                 

Phe Asn Leu Thr Pro Phe Val Gly Val Phe Leu Thr His Gly Trp Ala 
305                 310                 315                 320 

Arg Ala Gly Tyr Ala Leu Ala Leu Ala Ser Ile Ala Gly Ile Tyr Tyr 
                325                 330                 335     

Gly Met Ser Asp Arg Ser Thr Ile Pro Trp Tyr Tyr Val Val Leu His 
            340                 345                 350         

Pro Val Ser Thr Val Leu Phe Ala Tyr Thr Val Gly Arg Ser Met Val 
        355                 360                 365             

Val Thr Leu Ala Gln Asp Gly Ile Thr Trp Arg Gly Thr His Tyr Ser 
    370                 375                 380                 

Leu Asn Glu Leu Arg Lys Gly Val 
385                 390         

<210>   143
<211>   373
<212>   PRT
<213>   Anaeromyxobacter sp. K

<400>   143
Ala Leu Ala Leu Ala Gly Trp Ala Arg Val Ala Trp Ser Gly Leu Arg 
                5                   10                  15      

Ser Asp Arg Ala Leu Ala Arg Leu Glu Asp Leu Pro Ala Pro Arg Ser 
            20                  25                  30          

Val Pro Arg Val Ser Val Val Val Pro Cys Arg Asp Glu Ala Pro His 
        35                  40                  45              

Val Glu Arg Ala Val Arg Ser Leu Leu Ala Gln Asp Leu Pro Gly Leu 
    50                  55                  60                  

Glu Val Val Ala Val Asp Asp Arg Ser Arg Asp Glu Thr Gly Ala Ile 
65                  70                  75                  80  

Leu Asp Arg Leu Ala Ala Ala Glu Pro Arg Leu Ala Val Val His Val 
                85                  90                  95      

Arg Glu Leu Pro Ala Gly Trp Leu Gly Lys Asn His Ala Cys Ala Ala 
            100                 105                 110         

Gly Ala Arg Arg Ala Arg Gly Glu Trp Leu Leu Phe Thr Asp Gly Asp 
        115                 120                 125             

Val Val Phe Gly Pro Gly Ala Leu Arg Arg Ala Val Gly His Ala Glu 
    130                 135                 140                 

Ala Leu Gly Leu Gly His Leu Ala Ala Ala Pro Arg Phe Val Ala Pro 
145                 150                 155                 160 

Gly Ala Leu Glu Arg Ala Phe Val Ala Ala Phe Ala Ala Phe Ala Ala 
                165                 170                 175     

Gly Ala Phe Arg Val Trp Glu Leu Pro Arg Ala Gly Thr Arg Gly Phe 
            180                 185                 190         

Ala Gly Val Gly Ala Phe Asn Leu Val Arg Arg Asp Ala Tyr Glu Ala 
        195                 200                 205             

Val Gly Gly His Ala Arg Leu Arg Leu Glu Val Val Asp Asp Val Lys 
    210                 215                 220                 

Leu Gly Leu Leu Leu Arg Arg Ser Gly Val Pro Gln Gly Leu Val Asn 
225                 230                 235                 240 

Gly Gly Ala Leu Val Ser Val Arg Trp Gln His Gly Phe Val Pro Ser 
                245                 250                 255     

Val Leu Gly Leu Val Lys Asn Ala Phe Ala Gly Ala Glu Tyr Arg Val 
            260                 265                 270         

Ala Arg Ala Leu Gly Val Ala Leu Trp Ala Val Phe Leu Gly Ala Ala 
        275                 280                 285             

Pro Leu Ala Leu Ala Leu Ala Ala His Gly Gly Ala Ala Arg Ala Leu 
    290                 295                 300                 

Gly Gly Leu Ala Leu Ala Val Ser Val Gly Val Leu Gly Val Thr Ala 
305                 310                 315                 320 

Arg Arg Val Ala Gly Gly Gly Gly Ala Glu Gly Leu Leu Met Pro Pro 
                325                 330                 335     

Cys Thr Val Leu Leu Gly Ala Val Leu Leu Ala Ser Ala Ala Ala Ala 
            340                 345                 350         

Ala Trp Arg Gly Gly Val Val Trp Arg Gly Thr Phe Tyr Pro Leu Ala 
        355                 360                 365             

Ala Leu Arg Gln Gly 
    370             

<210>   144
<211>   397
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 137

<400>   144
Met Phe Ser Asn Phe Val Trp Ser Trp Leu Ala His Ala Leu Pro Arg 
                5                   10                  15      

Ala Ala Trp Leu Pro Val Leu Cys Ala Val Val Trp Thr Ala Ile Phe 
            20                  25                  30          

Leu Arg Thr Ile Pro Asp Leu Val Arg Thr Pro Arg Leu Arg Pro Arg 
        35                  40                  45              

Glu Ala Ala Arg Ala Ser Pro Pro Ser Tyr Gly Arg Val Ser Val Val 
    50                  55                  60                  

Val Ala Ala Arg Asp Glu Arg Glu His Ile Glu Val Thr Leu Glu Ser 
65                  70                  75                  80  

Leu Leu Lys Gln Thr Tyr Pro Asp Leu Glu Ile Val Ala Val Asp Asp 
                85                  90                  95      

Arg Ser Thr Asp Gly Thr Gly Asp Val Ile Asp Arg Met Ala Ala Ser 
            100                 105                 110         

Asp Ser Arg Ile Val Pro Val His Ile Arg Glu Leu Pro Arg Gly Trp 
        115                 120                 125             

Leu Gly Lys Asn His Ala Leu Tyr Ala Gly Ala Met Arg Ala Thr Gly 
    130                 135                 140                 

Asp Trp Leu Leu Phe Ala Asp Ala Asp Val Arg Phe Tyr Pro Asp Ala 
145                 150                 155                 160 

Val Glu Arg Ala Met Ala Tyr Val His Ala His Arg Leu His His Leu 
                165                 170                 175     

Thr Val Ala Pro Arg Leu Ile Ala Ser Gly Tyr Ala Leu Lys Leu Leu 
            180                 185                 190         

Thr Ala Met Tyr Ile Phe Asn Tyr Val Leu Phe Lys Arg Pro Gln Ser 
        195                 200                 205             

Ala Tyr Arg Arg Arg Thr Arg Ala His Ala Gly Ile Gly Ala Phe Asn 
    210                 215                 220                 

Leu Val Ser Arg Glu Ala Tyr Glu Arg Ile Gly Thr His Arg Ala Ile 
225                 230                 235                 240 

Ser Leu Arg Pro Asp Asp Asp Leu His Leu Gly Lys Leu Ile Lys Arg 
                245                 250                 255     

His Gly Phe Arg Gln Arg Phe Val Val Ala Gln Asp Met Ile Glu Ile 
            260                 265                 270         

Glu Trp Tyr Pro Ser Phe Arg Ala Met Val Val Gly Met Glu Lys Ala 
        275                 280                 285             

Pro Leu Pro Ala Phe His Tyr Ser Ala Val Leu Leu Thr Ala Ala Met 
    290                 295                 300                 

Met Val Met Met Val Leu Tyr Thr Thr Pro Phe Ala Gly Ala Ile Phe 
305                 310                 315                 320 

Gly Pro Gly Trp Tyr Arg Leu Val Tyr Leu Tyr Cys Leu Val Leu Met 
                325                 330                 335     

Gly Ile Leu Tyr Glu Leu His Ala Val Phe Leu Arg Leu Pro Lys His 
            340                 345                 350         

Gln Phe Leu Ile Leu Pro Leu Gly Met Leu Leu Tyr Ser Tyr Ala Phe 
        355                 360                 365             

Ile Arg Ser Ala Val Leu Ala Val Arg Arg Gly Gly Leu Val Trp Arg 
    370                 375                 380                 

Asp Thr Phe Tyr Thr Leu Arg Glu Leu Arg Arg Gly Leu 
385                 390                 395         

<210>   145
<211>   397
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 137

<400>   145
Met Phe Ser Asn Phe Val Trp Ser Trp Leu Ala His Ala Leu Pro Arg 
                5                   10                  15      

Ala Ala Trp Leu Pro Val Leu Cys Ala Val Val Trp Thr Ala Ile Phe 
            20                  25                  30          

Leu Arg Thr Ile Pro Asp Leu Val Arg Thr Pro Arg Leu Arg Pro Arg 
        35                  40                  45              

Glu Ala Ala Arg Ala Ser Pro Pro Ser Tyr Gly Arg Val Ser Val Val 
    50                  55                  60                  

Val Ala Ala Arg Asp Glu Arg Glu His Ile Glu Val Thr Leu Glu Ser 
65                  70                  75                  80  

Ile Leu Arg Gln Thr Tyr Pro Asp Leu Glu Ile Val Ala Val Asp Asp 
                85                  90                  95      

Arg Ser Thr Asp Gly Thr Gly Asp Val Ile Asp Arg Met Ala Ala Ser 
            100                 105                 110         

Asp Ser Arg Ile Val Pro Val His Ile Arg Glu Leu Pro Arg Gly Trp 
        115                 120                 125             

Leu Gly Lys Asn His Ala Leu Tyr Ala Gly Ala Met Arg Ala Thr Gly 
    130                 135                 140                 

Asp Trp Leu Leu Phe Ala Asp Ala Asp Val Arg Phe Tyr Pro Asp Ala 
145                 150                 155                 160 

Val Glu Arg Ala Met Ala Tyr Val His Ala His Arg Leu His His Leu 
                165                 170                 175     

Thr Val Ala Pro Arg Leu Ile Ala Ser Gly Tyr Ala Leu Lys Leu Leu 
            180                 185                 190         

Thr Ala Met Tyr Ile Phe Asn Tyr Val Leu Phe Lys Arg Pro Gln Ser 
        195                 200                 205             

Ala Tyr Arg Arg Arg Thr Arg Ala His Ala Gly Ile Gly Ala Phe Asn 
    210                 215                 220                 

Leu Val Ser Arg Glu Ala Tyr Glu Arg Ile Gly Thr His Arg Ala Ile 
225                 230                 235                 240 

Ser Leu Arg Pro Asp Asp Asp Leu His Leu Gly Lys Leu Ile Lys Arg 
                245                 250                 255     

His Gly Phe Arg Gln Arg Phe Val Val Ala Gln Asp Met Ile Glu Ile 
            260                 265                 270         

Glu Trp Tyr Pro Ser Phe Arg Ala Met Val Val Gly Met Glu Lys Ala 
        275                 280                 285             

Pro Leu Pro Ala Phe His Tyr Ser Ala Val Leu Leu Thr Ala Ala Met 
    290                 295                 300                 

Met Val Met Met Val Leu Tyr Thr Thr Pro Phe Ala Gly Ala Ile Phe 
305                 310                 315                 320 

Gly Pro Gly Trp Tyr Arg Leu Val Tyr Leu Tyr Cys Leu Val Leu Met 
                325                 330                 335     

Gly Ile Leu Tyr Glu Leu His Ala Val Phe Leu Arg Leu Pro Lys His 
            340                 345                 350         

Gln Phe Leu Ile Leu Pro Leu Gly Met Leu Leu Tyr Ser Tyr Ala Phe 
        355                 360                 365             

Ile Arg Ser Ala Val Leu Ala Val Arg Arg Gly Gly Leu Val Trp Arg 
    370                 375                 380                 

Asp Thr Phe Tyr Thr Leu Arg Glu Leu Arg Arg Gly Leu 
385                 390                 395         

<210>   146
<211>   397
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 137

<400>   146
Met Phe Ser Asn Phe Val Trp Ser Trp Leu Ala His Ala Leu Pro Arg 
                5                   10                  15      

Ala Ala Trp Leu Pro Val Leu Cys Ala Val Val Trp Thr Ala Ile Phe 
            20                  25                  30          

Leu Arg Thr Ile Pro Asp Leu Val Arg Thr Pro Arg Leu Arg Pro Arg 
        35                  40                  45              

Glu Ala Ala Arg Ala Ser Pro Pro Ser Tyr Gly Arg Val Ser Val Val 
    50                  55                  60                  

Val Ala Ala Arg Asp Glu Arg Glu His Ile Glu Val Thr Leu Glu Ser 
65                  70                  75                  80  

Leu Leu Arg Gln Thr Tyr Pro Asp Leu Glu Ile Val Ala Val Asp Asp 
                85                  90                  95      

Arg Ser Thr Asp Gly Thr Gly Asp Val Ile Asp Arg Met Ala Ala Ser 
            100                 105                 110         

Asp Ser Arg Ile Val Pro Val His Ile Arg Glu Leu Pro Arg Gly Trp 
        115                 120                 125             

Leu Gly Lys Asn His Ala Leu Tyr Ala Gly Ala Met Arg Ala Thr Gly 
    130                 135                 140                 

Asp Trp Leu Leu Phe Ala Asp Ala Asp Val Arg Phe Tyr Pro Asp Ala 
145                 150                 155                 160 

Val Glu Arg Ala Met Ala Tyr Val His Ala His Arg Leu His His Leu 
                165                 170                 175     

Thr Val Ala Pro Arg Leu Ile Ala Ser Gly Tyr Ala Leu Lys Leu Leu 
            180                 185                 190         

Thr Ala Met Tyr Ile Phe Asn Tyr Val Leu Phe Lys Arg Pro Gln Ser 
        195                 200                 205             

Ala Tyr Arg Arg Lys Thr Arg Ala His Ala Gly Ile Gly Ala Phe Asn 
    210                 215                 220                 

Leu Val Ser Arg Glu Ala Tyr Glu Arg Ile Gly Thr His Arg Ala Ile 
225                 230                 235                 240 

Ser Leu Arg Pro Asp Asp Asp Leu His Leu Gly Lys Leu Ile Lys Arg 
                245                 250                 255     

His Gly Phe Arg Gln Arg Phe Val Val Ala Gln Asp Met Ile Glu Ile 
            260                 265                 270         

Glu Trp Tyr Pro Ser Phe Arg Ala Met Val Val Gly Met Glu Lys Ala 
        275                 280                 285             

Pro Leu Pro Ala Phe His Tyr Ser Ala Val Leu Leu Thr Ala Ala Met 
    290                 295                 300                 

Met Val Met Met Val Leu Tyr Thr Thr Pro Phe Ala Gly Ala Ile Phe 
305                 310                 315                 320 

Gly Pro Gly Trp Tyr Arg Leu Val Tyr Leu Tyr Cys Leu Val Leu Met 
                325                 330                 335     

Gly Ile Leu Tyr Glu Leu His Ala Val Phe Leu Arg Leu Pro Lys His 
            340                 345                 350         

Gln Phe Leu Ile Leu Pro Leu Gly Met Leu Leu Tyr Ser Tyr Ala Phe 
        355                 360                 365             

Ile Arg Ser Ala Val Leu Ala Val Arg Arg Gly Gly Leu Val Trp Arg 
    370                 375                 380                 

Asp Thr Phe Tyr Thr Leu Arg Glu Leu Arg Arg Gly Leu 
385                 390                 395         

<210>   147
<211>   397
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 137

<400>   147
Met Phe Ser Asn Phe Val Trp Ser Trp Leu Ala His Ala Leu Pro Arg 
                5                   10                  15      

Ala Ala Trp Leu Pro Val Leu Cys Ala Val Val Trp Thr Ala Ile Phe 
            20                  25                  30          

Leu Arg Thr Ile Pro Asp Leu Val Arg Thr Pro Arg Leu Arg Pro Arg 
        35                  40                  45              

Glu Ala Ala Arg Ala Ser Pro Pro Ser Tyr Gly Lys Val Ser Val Val 
    50                  55                  60                  

Val Ala Ala Arg Asp Glu Arg Glu His Ile Glu Val Thr Leu Glu Ser 
65                  70                  75                  80  

Leu Leu Arg Gln Thr Tyr Pro Asp Leu Glu Ile Val Ala Val Asp Asp 
                85                  90                  95      

Arg Ser Thr Asp Gly Thr Gly Asp Val Ile Asp Arg Met Ala Ala Ser 
            100                 105                 110         

Asp Ser Arg Ile Val Pro Val His Ile Arg Glu Leu Pro Arg Gly Trp 
        115                 120                 125             

Leu Gly Lys Asn His Ala Leu Tyr Ala Gly Ala Met Arg Ala Thr Gly 
    130                 135                 140                 

Asp Trp Leu Leu Phe Ala Asp Ala Asp Val Arg Phe Tyr Pro Asp Ala 
145                 150                 155                 160 

Val Glu Arg Ala Met Ala Tyr Val His Ala His Arg Leu His His Leu 
                165                 170                 175     

Thr Val Ala Pro Arg Leu Ile Ala Ser Gly Tyr Ala Leu Lys Leu Leu 
            180                 185                 190         

Thr Ala Met Tyr Ile Phe Asn Tyr Val Leu Phe Lys Arg Pro Gln Ser 
        195                 200                 205             

Ala Tyr Arg Arg Arg Thr Arg Ala His Ala Gly Ile Gly Ala Phe Asn 
    210                 215                 220                 

Leu Val Ser Arg Glu Ala Tyr Glu Arg Ile Gly Thr His Arg Ala Ile 
225                 230                 235                 240 

Ser Leu Arg Pro Asp Asp Asp Leu His Leu Gly Lys Leu Ile Lys Arg 
                245                 250                 255     

His Gly Phe Arg Gln Arg Phe Val Val Ala Gln Asp Met Ile Glu Ile 
            260                 265                 270         

Glu Trp Tyr Pro Ser Phe Arg Ala Met Val Val Gly Met Glu Lys Ala 
        275                 280                 285             

Pro Leu Pro Ala Phe His Tyr Ser Ala Val Leu Leu Thr Ala Ala Met 
    290                 295                 300                 

Met Val Met Met Val Leu Tyr Thr Thr Pro Phe Ala Gly Ala Ile Phe 
305                 310                 315                 320 

Gly Pro Gly Trp Tyr Arg Leu Val Tyr Leu Tyr Cys Leu Val Leu Met 
                325                 330                 335     

Gly Ile Leu Tyr Glu Leu His Ala Val Phe Leu Arg Leu Pro Lys His 
            340                 345                 350         

Gln Phe Leu Ile Leu Pro Leu Gly Met Leu Leu Tyr Ser Tyr Ala Phe 
        355                 360                 365             

Ile Arg Ser Ala Val Leu Ala Val Arg Arg Gly Gly Leu Val Trp Arg 
    370                 375                 380                 

Asp Thr Phe Tyr Thr Leu Arg Glu Leu Arg Arg Gly Leu 
385                 390                 395         

<210>   148
<211>   397
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 137

<400>   148
Met Phe Ser Asn Phe Val Trp Ser Trp Leu Ala His Ala Leu Pro Arg 
                5                   10                  15      

Ala Ala Trp Leu Pro Val Ile Cys Ala Val Val Trp Thr Ala Ile Phe 
            20                  25                  30          

Leu Arg Thr Ile Pro Asp Leu Val Arg Thr Pro Arg Leu Arg Pro Arg 
        35                  40                  45              

Glu Ala Ala Arg Ala Ser Pro Pro Ser Tyr Gly Arg Val Ser Val Val 
    50                  55                  60                  

Val Ala Ala Arg Asp Glu Arg Glu His Ile Glu Val Thr Leu Glu Ser 
65                  70                  75                  80  

Leu Leu Arg Gln Thr Tyr Pro Asp Leu Glu Ile Val Ala Val Asp Asp 
                85                  90                  95      

Arg Ser Thr Asp Gly Thr Gly Asp Val Ile Asp Arg Met Ala Ala Ser 
            100                 105                 110         

Asp Ser Arg Ile Val Pro Val His Ile Arg Glu Leu Pro Arg Gly Trp 
        115                 120                 125             

Leu Gly Lys Asn His Ala Leu Tyr Ala Gly Ala Met Arg Ala Thr Gly 
    130                 135                 140                 

Asp Trp Leu Leu Phe Ala Asp Ala Asp Val Arg Phe Tyr Pro Asp Ala 
145                 150                 155                 160 

Val Glu Arg Ala Met Ala Tyr Val His Ala His Arg Leu His His Leu 
                165                 170                 175     

Thr Val Ala Pro Arg Leu Ile Ala Ser Gly Tyr Ala Leu Lys Leu Leu 
            180                 185                 190         

Thr Ala Met Tyr Ile Phe Asn Tyr Val Leu Phe Lys Arg Pro Gln Ser 
        195                 200                 205             

Ala Tyr Arg Arg Arg Thr Arg Ala His Ala Gly Ile Gly Ala Phe Asn 
    210                 215                 220                 

Leu Val Ser Arg Glu Ala Tyr Glu Arg Ile Gly Thr His Arg Ala Ile 
225                 230                 235                 240 

Ser Leu Arg Pro Asp Asp Asp Leu His Leu Gly Lys Leu Ile Lys Arg 
                245                 250                 255     

His Gly Phe Arg Gln Arg Phe Val Val Ala Gln Asp Met Ile Glu Ile 
            260                 265                 270         

Glu Trp Tyr Pro Ser Phe Arg Ala Met Val Val Gly Met Glu Lys Ala 
        275                 280                 285             

Pro Leu Pro Ala Phe His Tyr Ser Ala Val Leu Leu Thr Ala Ala Met 
    290                 295                 300                 

Met Val Met Met Val Leu Tyr Thr Thr Pro Phe Ala Gly Ala Ile Phe 
305                 310                 315                 320 

Gly Pro Gly Trp Tyr Arg Leu Val Tyr Leu Tyr Cys Leu Val Leu Met 
                325                 330                 335     

Gly Ile Leu Tyr Glu Leu His Ala Val Phe Leu Arg Leu Pro Lys His 
            340                 345                 350         

Gln Phe Leu Ile Leu Pro Leu Gly Met Leu Leu Tyr Ser Tyr Ala Phe 
        355                 360                 365             

Ile Arg Ser Ala Val Leu Ala Val Arg Arg Gly Gly Leu Val Trp Arg 
    370                 375                 380                 

Asp Thr Phe Tyr Thr Leu Arg Glu Leu Arg Arg Gly Leu 
385                 390                 395         

<210>   149
<211>   1194
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 138

<400>   149
atgttctcca acttcgtgtg gtcctggctt gcgcacgcgc ttccgcgggc ggcgtggctg       60

cccgtcctgt gcgcggtggt gtggacggcc atctttctcc gcaccatccc ggacctcgtg      120

cgaacgccgc gccttcggcc ccgtgaggcg gcgagagcga gcccaccgtc ctatggccgc      180

gtgagcgtcg tggtggcggc gcgcgatgag cgggagcaca tcgaggtcac gctcgaatcg      240

ctgctgaaac agacgtatcc ggatctcgaa atcgtcgcgg ttgacgatcg gtcgacggac      300

gggacgggcg acgtgatcga ccggatggcg gccagcgatt cgcgcattgt gccggtgcac      360

atccgagagc tgccgcgtgg atggctgggc aagaaccacg ccctgtatgc aggcgctatg      420

cgcgcgacgg gcgattggct gctgtttgcg gacgcggacg tgcggtttta cccggacgcg      480

gtggaacggg ccatggccta cgtgcacgcg catcggctgc atcacctgac cgtggcgccg      540

aggctcatcg catccggcta cgcgctgaag ctattgacgg ccatgtacat cttcaactat      600

gtgctgttca agcggcccca gagcgcgtac cgcaggcgca ctcgcgcaca cgccggcatc      660

ggcgcgttca acctcgtcag ccgcgaggcg tacgagcgca tcggcacgca tcgagccatc      720

agcttacgtc ccgacgacga tctccacctc ggcaagctca tcaagcggca tggatttcgg      780

cagcgattcg tcgtggcgca ggacatgatc gagatcgagt ggtatccgag cttccgcgcg      840

atggtcgtcg gcatggagaa agcgccgctg ccggcatttc actattccgc ggtgcttttg      900

acggcggcca tgatggtgat gatggtgctc tacacgacgc ctttcgcagg ggccatcttc      960

ggaccgggtt ggtatcgatt ggtttatctg tattgtctcg tcctcatggg aatcttatat     1020

gaacttcatg cggtgttttt gagactgccc aagcaccagt tcctcatcct gccgctcggc     1080

atgctgctgt acagctacgc cttcattcgt tcggccgtgc tggcggttcg ccgaggaggg     1140

ctcgtgtggc gggacacgtt ttacacgctg cgcgaactgc gccgaggtct gtga           1194


<210>   150
<211>   1194
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 138

<400>   150
atgttctcca acttcgtgtg gtcctggctt gcgcacgcgc ttccgcgggc ggcgtggctg       60

cccgtcctgt gcgcggtggt gtggacggcc atctttctcc gcaccatccc ggacctcgtg      120

cgaacgccgc gccttcggcc ccgtgaggcg gcgagagcga gcccaccgtc ctatggccgc      180

gtgagcgtcg tggtggcggc gcgcgatgag cgggagcaca tcgaggtcac gctcgaatcg      240

attctgcgcc agacgtatcc ggatctcgaa atcgtcgcgg ttgacgatcg gtcgacggac      300

gggacgggcg acgtgatcga ccggatggcg gccagcgatt cgcgcattgt gccggtgcac      360

atccgagagc tgccgcgtgg atggctgggc aagaaccacg ccctgtatgc aggcgctatg      420

cgcgcgacgg gcgattggct gctgtttgcg gacgcggacg tgcggtttta cccggacgcg      480

gtggaacggg ccatggccta cgtgcacgcg catcggctgc atcacctgac cgtggcgccg      540

aggctcatcg catccggcta cgcgctgaag ctattgacgg ccatgtacat cttcaactat      600

gtgctgttca agcggcccca gagcgcgtac cgcaggcgca ctcgcgcaca cgccggcatc      660

ggcgcgttca acctcgtcag ccgcgaggcg tacgagcgca tcggcacgca tcgagccatc      720

agcttacgtc ccgacgacga tctccacctc ggcaagctca tcaagcggca tggatttcgg      780

cagcgattcg tcgtggcgca ggacatgatc gagatcgagt ggtatccgag cttccgcgcg      840

atggtcgtcg gcatggagaa agcgccgctg ccggcatttc actattccgc ggtgcttttg      900

acggcggcca tgatggtgat gatggtgctc tacacgacgc ctttcgcagg ggccatcttc      960

ggaccgggtt ggtatcgatt ggtttatctg tattgtctcg tcctcatggg aatcttatat     1020

gaacttcatg cggtgttttt gagactgccc aagcaccagt tcctcatcct gccgctcggc     1080

atgctgctgt acagctacgc cttcattcgt tcggccgtgc tggcggttcg ccgaggaggg     1140

ctcgtgtggc gggacacgtt ttacacgctg cgcgaactgc gccgaggtct gtga           1194


<210>   151
<211>   1194
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 138

<400>   151
atgttctcca acttcgtgtg gtcctggctt gcgcacgcgc ttccgcgggc ggcgtggctg       60

cccgtcctgt gcgcggtggt gtggacggcc atctttctcc gcaccatccc ggacctcgtg      120

cgaacgccgc gccttcggcc ccgtgaggcg gcgagagcga gcccaccgtc ctatggccgc      180

gtgagcgtcg tggtggcggc gcgcgatgag cgggagcaca tcgaggtcac gctcgaatcg      240

ctgctgcgcc agacgtatcc ggatctcgaa atcgtcgcgg ttgacgatcg gtcgacggac      300

gggacgggcg acgtgatcga ccggatggcg gccagcgatt cgcgcattgt gccggtgcac      360

atccgagagc tgccgcgtgg atggctgggc aagaaccacg ccctgtatgc aggcgctatg      420

cgcgcgacgg gcgattggct gctgtttgcg gacgcggacg tgcggtttta cccggacgcg      480

gtggaacggg ccatggccta cgtgcacgcg catcggctgc atcacctgac cgtggcgccg      540

aggctcatcg catccggcta cgcgctgaag ctattgacgg ccatgtacat cttcaactat      600

gtgctgttca agcggcccca gagcgcgtac cgcaggaaaa ctcgcgcaca cgccggcatc      660

ggcgcgttca acctcgtcag ccgcgaggcg tacgagcgca tcggcacgca tcgagccatc      720

agcttacgtc ccgacgacga tctccacctc ggcaagctca tcaagcggca tggatttcgg      780

cagcgattcg tcgtggcgca ggacatgatc gagatcgagt ggtatccgag cttccgcgcg      840

atggtcgtcg gcatggagaa agcgccgctg ccggcatttc actattccgc ggtgcttttg      900

acggcggcca tgatggtgat gatggtgctc tacacgacgc ctttcgcagg ggccatcttc      960

ggaccgggtt ggtatcgatt ggtttatctg tattgtctcg tcctcatggg aatcttatat     1020

gaacttcatg cggtgttttt gagactgccc aagcaccagt tcctcatcct gccgctcggc     1080

atgctgctgt acagctacgc cttcattcgt tcggccgtgc tggcggttcg ccgaggaggg     1140

ctcgtgtggc gggacacgtt ttacacgctg cgcgaactgc gccgaggtct gtga           1194


<210>   152
<211>   1194
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 138

<400>   152
atgttctcca acttcgtgtg gtcctggctt gcgcacgcgc ttccgcgggc ggcgtggctg       60

cccgtcctgt gcgcggtggt gtggacggcc atctttctcc gcaccatccc ggacctcgtg      120

cgaacgccgc gccttcggcc ccgtgaggcg gcgagagcga gcccaccgtc ctatggcaaa      180

gtgagcgtcg tggtggcggc gcgcgatgag cgggagcaca tcgaggtcac gctcgaatcg      240

ctgctgcgcc agacgtatcc ggatctcgaa atcgtcgcgg ttgacgatcg gtcgacggac      300

gggacgggcg acgtgatcga ccggatggcg gccagcgatt cgcgcattgt gccggtgcac      360

atccgagagc tgccgcgtgg atggctgggc aagaaccacg ccctgtatgc aggcgctatg      420

cgcgcgacgg gcgattggct gctgtttgcg gacgcggacg tgcggtttta cccggacgcg      480

gtggaacggg ccatggccta cgtgcacgcg catcggctgc atcacctgac cgtggcgccg      540

aggctcatcg catccggcta cgcgctgaag ctattgacgg ccatgtacat cttcaactat      600

gtgctgttca agcggcccca gagcgcgtac cgcaggcgca ctcgcgcaca cgccggcatc      660

ggcgcgttca acctcgtcag ccgcgaggcg tacgagcgca tcggcacgca tcgagccatc      720

agcttacgtc ccgacgacga tctccacctc ggcaagctca tcaagcggca tggatttcgg      780

cagcgattcg tcgtggcgca ggacatgatc gagatcgagt ggtatccgag cttccgcgcg      840

atggtcgtcg gcatggagaa agcgccgctg ccggcatttc actattccgc ggtgcttttg      900

acggcggcca tgatggtgat gatggtgctc tacacgacgc ctttcgcagg ggccatcttc      960

ggaccgggtt ggtatcgatt ggtttatctg tattgtctcg tcctcatggg aatcttatat     1020

gaacttcatg cggtgttttt gagactgccc aagcaccagt tcctcatcct gccgctcggc     1080

atgctgctgt acagctacgc cttcattcgt tcggccgtgc tggcggttcg ccgaggaggg     1140

ctcgtgtggc gggacacgtt ttacacgctg cgcgaactgc gccgaggtct gtga           1194


<210>   153
<211>   1194
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 138

<400>   153
atgttctcca acttcgtgtg gtcctggctt gcgcacgcgc ttccgcgggc ggcgtggctg       60

cccgtcattt gcgcggtggt gtggacggcc atctttctcc gcaccatccc ggacctcgtg      120

cgaacgccgc gccttcggcc ccgtgaggcg gcgagagcga gcccaccgtc ctatggccgc      180

gtgagcgtcg tggtggcggc gcgcgatgag cgggagcaca tcgaggtcac gctcgaatcg      240

ctgctgcgcc agacgtatcc ggatctcgaa atcgtcgcgg ttgacgatcg gtcgacggac      300

gggacgggcg acgtgatcga ccggatggcg gccagcgatt cgcgcattgt gccggtgcac      360

atccgagagc tgccgcgtgg atggctgggc aagaaccacg ccctgtatgc aggcgctatg      420

cgcgcgacgg gcgattggct gctgtttgcg gacgcggacg tgcggtttta cccggacgcg      480

gtggaacggg ccatggccta cgtgcacgcg catcggctgc atcacctgac cgtggcgccg      540

aggctcatcg catccggcta cgcgctgaag ctattgacgg ccatgtacat cttcaactat      600

gtgctgttca agcggcccca gagcgcgtac cgcaggcgca ctcgcgcaca cgccggcatc      660

ggcgcgttca acctcgtcag ccgcgaggcg tacgagcgca tcggcacgca tcgagccatc      720

agcttacgtc ccgacgacga tctccacctc ggcaagctca tcaagcggca tggatttcgg      780

cagcgattcg tcgtggcgca ggacatgatc gagatcgagt ggtatccgag cttccgcgcg      840

atggtcgtcg gcatggagaa agcgccgctg ccggcatttc actattccgc ggtgcttttg      900

acggcggcca tgatggtgat gatggtgctc tacacgacgc ctttcgcagg ggccatcttc      960

ggaccgggtt ggtatcgatt ggtttatctg tattgtctcg tcctcatggg aatcttatat     1020

gaacttcatg cggtgttttt gagactgccc aagcaccagt tcctcatcct gccgctcggc     1080

atgctgctgt acagctacgc cttcattcgt tcggccgtgc tggcggttcg ccgaggaggg     1140

ctcgtgtggc gggacacgtt ttacacgctg cgcgaactgc gccgaggtct gtga           1194


<210>   154
<211>   470
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   154
Met Asn Phe Ala Asn Glu Lys Phe Arg Leu Ser Leu Gly His Val Pro 
                5                   10                  15      

Ser Glu Met His Cys Ala Gln His Ile Arg Ile Glu Ala Arg Gly Ala 
            20                  25                  30          

Val Arg Glu Phe Ala Arg Ser Gly Ala Gly Thr Arg Pro Asp Arg Arg 
        35                  40                  45              

Gly Gly Ser Ser Ser Pro Val Arg Ser Lys Arg Arg Met Val His Ser 
    50                  55                  60                  

Phe Leu Phe Leu Tyr Pro Phe Val Met Ser Ile Val Trp Met Val Gly 
65                  70                  75                  80  

Gly Cys Val Tyr Ala Trp Arg Arg Glu Arg His Pro Phe Ala Glu Ser 
                85                  90                  95      

Pro Asp Leu Pro Glu Thr Pro Phe Val Ser Ile Leu Ile Pro Cys His 
            100                 105                 110         

Asn Glu Gly Asp Val Leu Glu Asp Thr Ile Gly Arg Met Leu Gln Leu 
        115                 120                 125             

Asp Tyr Pro Ala Tyr Glu Ile Val Ala Leu Asn Asp Gly Ser Thr Asp 
    130                 135                 140                 

Asp Thr Arg Ala Val Leu Glu Arg Met Ala Ala Cys Asp Ala Arg Val 
145                 150                 155                 160 

Arg Val Val Asn Leu Pro Val Gln Arg Gly Lys Ala Arg Ala Leu Asn 
                165                 170                 175     

Ala Gly Leu Val Ala Ser Arg Gly Glu Ile Leu Val Thr Val Asp Ala 
            180                 185                 190         

Asp Ala Val Leu Ala Lys Asp Ala Leu Arg Phe Leu Val Trp His Phe 
        195                 200                 205             

Val Ala Pro Gly Ser Glu Arg Val Gly Ala Val Thr Gly Asn Pro Arg 
    210                 215                 220                 

Ile Arg Asn Arg Gly Thr Leu Leu Gly Lys Ile Gln Val Leu Glu Tyr 
225                 230                 235                 240 

Ala Ser Ile Ile Gly Leu Ile Lys Arg Ala Gln Arg Val Leu Gly Lys 
                245                 250                 255     

Ile Met Thr Val Ser Gly Val Ile Ala Ala Phe Arg Lys Arg Ala Leu 
            260                 265                 270         

Val Asp Cys Gly Met Trp Asp Glu Asp Met Val Thr Asp Asp Ile Ala 
        275                 280                 285             

Val Ser Trp Lys Leu Glu Arg Arg Ala Trp Asp Ile Arg Tyr Glu Pro 
    290                 295                 300                 

Arg Ala Leu Cys Phe Met Trp Ala Pro Glu Arg Leu Arg Ser Leu Ile 
305                 310                 315                 320 

Arg Gln Arg Ala Arg Trp Ala Gln Gly Gly Val Glu Val Leu Ile Arg 
                325                 330                 335     

Asn Ala Ser Val Leu Trp Thr Trp Lys Asn Arg Arg Met Ile Pro Leu 
            340                 345                 350         

Tyr Val Glu Glu Leu Leu Gly Ile Ala Trp Ala Tyr Leu Trp Val Val 
        355                 360                 365             

Ser Leu Val Trp Thr Leu Ala Phe Asp Val Ala His Gly Ile Pro Trp 
    370                 375                 380                 

Thr Tyr Val Ala Glu Thr Gly Thr Trp Leu Gly Leu Thr Ser Leu Val 
385                 390                 395                 400 

Gln Thr Ser Val Ala Leu Trp Ile Glu Gln Arg Tyr Glu Arg Asp Ser 
                405                 410                 415     

Leu Trp Arg Tyr Tyr Phe Tyr Ala Ile Trp Tyr Pro Ala Ala Tyr Trp 
            420                 425                 430         

Met Ile Gly Ala Phe Val Val Val Trp Ala Val Pro Lys Ala Cys Trp 
        435                 440                 445             

Ala Met Trp Ala Ala Arg Arg Gly Arg Tyr Ala Thr Trp Lys Ser Pro 
    450                 455                 460                 

Asp Arg Gly Val Ser Ala 
465                 470 

<210>   155
<211>   1413
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   155
ttgaacttcg ctaatgaaaa atttaggctg tcgcttgggc atgtgccgtc ggaaatgcat       60

tgcgcacaac atattcgtat cgaagctcgc ggagcggtcc gcgagttcgc gcgatccggc      120

gcagggactc ggccggatcg ccgcggtgga agctcgagtc cagtgaggag caaacggcgc      180

atggtgcatt cttttctgtt cctgtatccc tttgtcatga gcatcgtctg gatggtgggc      240

ggctgtgtct atgcctggcg gcgcgaacgc caccccttcg ccgaatcccc ggacctcccc      300

gagacgccgt ttgtttccat cctcatcccc tgccacaacg aaggggatgt gctcgaagac      360

accatcggcc ggatgcttca gttggattat ccggcgtacg aaattgtcgc actgaacgac      420

ggcagcacgg acgacacgcg cgcggtgctc gaacgcatgg cggcctgcga tgcgcgagtt      480

cgcgtggtca acctgcccgt tcagcgcgga aaggcgcgcg cgctgaacgc tgggcttgtc      540

gcgtcccgag gcgagatcct cgtgaccgtg gacgcggacg ccgtgttggc gaaggacgcg      600

cttcgcttcc tcgtctggca cttcgtggcc ccgggcagcg agcgcgtcgg tgccgtgacg      660

ggcaacccgc gcattcgaaa tcgcggtacg ctgctcggaa agattcaggt gctggagtac      720

gcgagcatca tcgggctcat caagcgcgcg cagcgcgtgc tcggcaagat catgacggtc      780

tcgggcgtga ttgcggcctt tcgcaagagg gccctcgtgg actgcggcat gtgggacgag      840

gacatggtga cggatgacat cgcggtgtcc tggaagctcg agcggcgagc ctgggacatc      900

cgatacgagc cgcgagcgct ctgcttcatg tgggcgcccg agcgcctgcg gagcctcatc      960

cgccagcgcg ctcgctgggc gcagggcggc gtggaggtcc tcatccgcaa cgcctcggtc     1020

ctctggacct ggaagaatcg gcgcatgatc ccgctctatg tggaagagct cctgggcatc     1080

gcctgggcgt acctttgggt tgtgagcctc gtgtggaccc tcgcatttga cgtggcgcac     1140

ggcattccct ggacgtacgt ggcggagacg gggacgtggc tcggcctgac atcgttagtg     1200

cagacctcgg tcgccctttg gattgagcag cgatacgagc gcgactcgct ctggcgctac     1260

tatttctatg ccatctggta tccggccgcg tattggatga tcggcgcgtt cgtcgtggtc     1320

tgggcggtgc cgaaggcgtg ctgggccatg tgggcggctc ggcgcgggcg gtacgccacg     1380

tggaaaagcc cggatcgggg ggtgtcggca tga                                  1413


<210>   156
<211>   401
<212>   PRT
<213>   Thermosinus carboxydivorans Nor1

<400>   156
Phe Val Phe Tyr Tyr Pro Leu Val Met Ser Ile Val Trp Ile Val Gly 
                5                   10                  15      

Ala Phe Tyr Phe Tyr Leu Arg Arg Glu Ala Gly Arg Arg Arg Arg Pro 
            20                  25                  30          

Pro Val Leu Ala Glu Tyr Pro Leu Val Ser Val Leu Ile Pro Ala His 
        35                  40                  45              

Asn Glu Glu Gln Ser Ile Arg Ala Thr Ile Ala Ser Val Leu Lys Ser 
    50                  55                  60                  

Asn Tyr Pro Asn Phe Glu Ile Val Val Val Asp Asp Gly Ser Thr Asp 
65                  70                  75                  80  

Ala Thr Pro Arg Ile Leu Leu Glu Leu Ala Ala Glu Cys Pro Ala Val 
                85                  90                  95      

Arg Val Leu Ile Met Lys Gln Asn Met Gly Lys Pro Ser Ala Leu Arg 
            100                 105                 110         

Tyr Gly Leu Met Ala Cys Arg Gly Glu Ile Ile Leu Ala Met Asp Ala 
        115                 120                 125             

Asp Ala Phe Leu Asp Ala Asn Ala Met Arg Trp Leu Val Ala His Phe 
    130                 135                 140                 

Val Ala Gly Pro Arg Val Gly Ala Val Thr Gly Asn Pro Arg Val Arg 
145                 150                 155                 160 

Asn Arg Thr Ser Leu Ile Ala Lys Ile Gln Val Gly Glu Tyr Ser Ser 
                165                 170                 175     

Ile Ile Gly Met Ile Lys Arg Thr Gln Arg Ile Leu Gly Lys Val Leu 
            180                 185                 190         

Thr Val Ser Gly Val Ile Ala Ala Phe Arg Lys Arg Ala Leu Leu Asp 
        195                 200                 205             

Val Gly Leu Trp Asp Ile Asp Met Ile Thr Asp Asp Ile Asn Val Thr 
    210                 215                 220                 

Trp Lys Leu Glu Lys His Phe Trp Asp Val Arg Tyr Glu Pro Asn Ala 
225                 230                 235                 240 

Leu Cys Trp Ile Leu Val Pro Glu Thr Leu Lys Gly Leu Trp Arg Gln 
                245                 250                 255     

Arg Val Arg Trp Ala Gln Gly Gly Val Glu Val Ile Arg Arg His Ala 
            260                 265                 270         

Gly Ile Trp Thr Asp Trp Arg Gln Arg Arg Leu Trp Pro Val Tyr Ile 
        275                 280                 285             

Glu Tyr Val Ile Ser Val Cys Trp Ser Tyr Ala Phe Val Ser Phe Gly 
    290                 295                 300                 

Gly Leu Trp Leu Leu Asn Phe Ile Phe Pro His Asp Leu Pro Val Ala 
305                 310                 315                 320 

Lys Ile Phe Pro Glu Trp Lys Gly Ala Val Leu Val Ser Leu Cys Leu 
                325                 330                 335     

Val Gln Ser Ala Ile Ala Leu Trp Ile Asp Arg Arg Tyr Glu Lys Asn 
            340                 345                 350         

Ile Leu Trp Tyr Tyr Phe Trp Val Ile Trp Tyr Pro Phe Val Tyr Trp 
        355                 360                 365             

Val Ile Ser Ala Leu Ala Thr Val Trp Ala Ala Pro Arg Ala Leu Phe 
    370                 375                 380                 

Gly His Ser Lys Gly Lys Leu Ala Val Trp Gln Ser Pro Asp Arg Gly 
385                 390                 395                 400 

Leu 
    

<210>   157
<211>   410
<212>   PRT
<213>   Stenotrophomonas maltophilia R551-3

<400>   157
Gln Val Leu Phe Gln Phe Ala Phe Tyr Tyr Pro Met Val Met Ala Phe 
                5                   10                  15      

Phe Trp Met Ser Gly Gly Leu Tyr Tyr Tyr Phe Arg Arg Glu Arg His 
            20                  25                  30          

Ser Arg Pro Arg Asn Asp Pro Pro Leu Met Ile Asp Pro Pro Phe Ala 
        35                  40                  45              

Ser Leu Leu Ile Pro Cys His Asn Glu Ser Glu Asn Leu Asp Asp Thr 
    50                  55                  60                  

Leu Gly Ala Ala Leu Ala Gln Arg Tyr Pro Ala Asp Tyr Glu Val Ile 
65                  70                  75                  80  

Ala Ile Asp Asp Gly Ser Ser Asp Asp Thr Gly Ala Arg Leu Asp Ala 
                85                  90                  95      

Leu Ala Ala Lys His Pro Arg Leu Arg Val Leu His Leu Asp Arg Asn 
            100                 105                 110         

Leu Gly Lys Ala Asn Ala Leu Arg Met Gly Ala Leu Ala Ala Arg Ser 
        115                 120                 125             

Glu Tyr Leu Val Cys Ile Asp Gly Asp Ala Met Leu Glu Glu His Ala 
    130                 135                 140                 

Leu His Trp Met Ile Trp His Leu Val Ser Gly Ser Arg Val Gly Ala 
145                 150                 155                 160 

Val Thr Gly Asn Pro Arg Ile Arg Asn Arg Ser Thr Leu Leu Gly Arg 
                165                 170                 175     

Leu Gln Val Ala Glu Phe Ser Ser Ile Ile Gly Met Ile Lys Arg Ala 
            180                 185                 190         

Gln Arg Val Tyr Gly Arg Ile Phe Thr Ile Ser Gly Val Ile Ala Gly 
        195                 200                 205             

Phe Arg Arg Thr Ala Leu His Gln Val Gly Trp Trp Ser Asp Asp Met 
    210                 215                 220                 

Val Thr Glu Asp Ile Asp Ile Ser Trp Arg Leu Gln Arg Ala His Trp 
225                 230                 235                 240 

Asp Ile Arg Tyr Glu Pro Asn Ala Leu Cys Phe Ile Leu Met Pro Glu 
                245                 250                 255     

Thr Leu Lys Gly Leu Trp Arg Gln Arg Leu Arg Trp Ala Gln Gly Gly 
            260                 265                 270         

Val Glu Val Met Leu Arg His Ala Arg Ser Leu Leu His Trp Lys Glu 
        275                 280                 285             

Arg Arg Met Trp Gly Val Leu Leu Glu Tyr Val Leu Ser Val Val Trp 
    290                 295                 300                 

Ala Tyr Thr Met Leu Phe Ile Val Val Leu Trp Ala Leu Gly Lys Phe 
305                 310                 315                 320 

Ile Glu Met Pro Pro Gln Leu Tyr Ile Ala Ser Leu Leu Ala Gln Trp 
                325                 330                 335     

His Gly Val Ile Leu Ala Leu Val Cys Leu Leu Gln Phe Ala Ser Ser 
            340                 345                 350         

Leu Ile Ile Asp Arg Arg Tyr Glu Thr Gln Ile Gly Arg Asn Tyr Phe 
        355                 360                 365             

Trp Val Ile Trp Tyr Pro Met Ala Tyr Trp Leu Ile Ser Leu Ser Thr 
    370                 375                 380                 

Thr Leu Val Ala Leu Pro Lys Thr Leu Leu Arg Arg Arg Ser Lys Arg 
385                 390                 395                 400 

Ala Thr Trp Thr Ser Pro Asp Arg Gly Ile 
                405                 410 

<210>   158
<211>   404
<212>   PRT
<213>   Xanthomonas oryzae pv. oryzae KACC10331

<400>   158
Phe Ala Phe Phe Tyr Pro Ile Met Met Ala Phe Phe Trp Ile Ser Gly 
                5                   10                  15      

Gly Leu Tyr Tyr Phe Leu Arg Arg Glu Arg Lys Ser Arg Pro Arg Asn 
            20                  25                  30          

Asp Pro Pro Pro Met Gly His Tyr Pro Ser Ala Ser Leu Leu Ile Pro 
        35                  40                  45              

Cys His Asn Glu Ser Asp Asn Leu Asp Asp Thr Ile Gly Asn Ala Leu 
    50                  55                  60                  

Ala Gln Arg Tyr Pro Asp Phe Glu Val Ile Ala Ile Asn Asp Gly Ser 
65                  70                  75                  80  

Arg Asp Asp Thr Gly Ala Arg Leu Asp Ile Leu Ala Ala Arg His Pro 
                85                  90                  95      

Arg Leu Arg Val Ile His Leu Asp Arg Asn Leu Gly Lys Ala Asn Ala 
            100                 105                 110         

Leu Arg Met Gly Ala Leu Ala Ala Arg Ser Glu Tyr Leu Ile Cys Ile 
        115                 120                 125             

Asp Gly Asp Ala Met Leu Glu Glu Phe Ala Met His Trp Met Val Trp 
    130                 135                 140                 

His Leu Ser Ser Ser Pro Arg Val Gly Ala Val Thr Gly Asn Pro Arg 
145                 150                 155                 160 

Ile Arg Asn Arg Ser Thr Leu Leu Gly Arg Leu Gln Val Ala Glu Phe 
                165                 170                 175     

Ser Ser Ile Ile Gly Met Ile Lys Arg Ala Gln Arg Val Tyr Gly Arg 
            180                 185                 190         

Ile Phe Thr Val Ser Gly Val Ile Ala Gly Phe Arg Arg Thr Ala Leu 
        195                 200                 205             

His Arg Ile Gly Tyr Trp Ala Asp Asp Met Met Thr Glu Asp Ile Asp 
    210                 215                 220                 

Ile Ser Trp Arg Leu Gln Leu Asp His Trp Asp Ile Arg Tyr Glu Pro 
225                 230                 235                 240 

Asn Ala Leu Cys Phe Ile Leu Met Pro Glu Thr Leu Lys Gly Leu Trp 
                245                 250                 255     

Arg Gln Arg Leu Arg Trp Ala Gln Gly Gly Val Glu Val Leu Leu Arg 
            260                 265                 270         

His Gly Arg Ser Leu Phe Ser Trp Arg Lys Arg Arg Met Trp Gly Val 
        275                 280                 285             

Leu Leu Glu Tyr Ile Leu Ser Val Leu Trp Ala Tyr Ser Ile Val Leu 
    290                 295                 300                 

Ile Ala Val Leu Trp Ala Pro Arg Gln Phe Phe Ala Leu Pro Thr Ala 
305                 310                 315                 320 

Val Ser Ile His Gly Leu Leu Pro Gln Trp His Gly Ala Ala Met Val 
                325                 330                 335     

Leu Val Cys Leu Leu Gln Phe Ala Ser Ser Leu Ile Ile Asp Arg Arg 
            340                 345                 350         

Tyr Glu Lys Gly Ile Gly Arg Asn Tyr Phe Trp Val Ile Trp Tyr Pro 
        355                 360                 365             

Ile Ala Tyr Trp Leu Leu Ser Leu Cys Thr Thr Val Val Ala Leu Pro 
    370                 375                 380                 

Lys Thr Leu Leu Thr Arg Arg Gly Lys Arg Ala Ile Trp Val Ser Pro 
385                 390                 395                 400 

Asp Arg Gly Ile 
                

<210>   159
<211>   404
<212>   PRT
<213>   Xanthomonas oryzae pv. oryzae MAFF 311018

<400>   159
Phe Ala Phe Phe Tyr Pro Ile Met Met Ala Phe Phe Trp Ile Ser Gly 
                5                   10                  15      

Gly Leu Tyr Tyr Phe Leu Arg Arg Glu Arg Lys Ser Arg Pro Arg Asn 
            20                  25                  30          

Asp Pro Pro Pro Met Gly His Tyr Pro Ser Ala Ser Leu Leu Ile Pro 
        35                  40                  45              

Cys His Asn Glu Ser Asp Asn Leu Asp Asp Thr Ile Gly Asn Ala Leu 
    50                  55                  60                  

Ala Gln Arg Tyr Pro Asp Phe Glu Val Ile Ala Ile Asn Asp Gly Ser 
65                  70                  75                  80  

Arg Asp Asp Thr Gly Ala Arg Leu Asp Ile Leu Ala Ala Arg His Pro 
                85                  90                  95      

Arg Leu Arg Val Ile His Leu Asp Arg Asn Leu Gly Lys Ala Asn Ala 
            100                 105                 110         

Leu Arg Met Gly Ala Leu Ala Ala Arg Ser Glu Tyr Leu Ile Cys Ile 
        115                 120                 125             

Asp Gly Asp Ala Met Leu Glu Glu Phe Ala Met His Trp Met Val Trp 
    130                 135                 140                 

His Leu Ser Ser Ser Pro Arg Val Gly Ala Val Thr Gly Asn Pro Arg 
145                 150                 155                 160 

Ile Arg Asn Arg Ser Thr Leu Leu Gly Arg Leu Gln Val Ala Glu Phe 
                165                 170                 175     

Ser Ser Ile Ile Gly Met Ile Lys Arg Ala Gln Arg Val Tyr Gly Arg 
            180                 185                 190         

Ile Phe Thr Val Ser Gly Val Ile Ala Gly Phe Arg Arg Thr Ala Leu 
        195                 200                 205             

His Arg Ile Gly Tyr Trp Ala Asp Asp Met Met Thr Glu Asp Ile Asp 
    210                 215                 220                 

Ile Ser Trp Arg Leu Gln Leu Asp His Trp Asp Ile Arg Tyr Glu Pro 
225                 230                 235                 240 

Asn Ala Leu Cys Phe Ile Leu Met Pro Glu Thr Leu Lys Gly Leu Trp 
                245                 250                 255     

Arg Gln Arg Leu Arg Trp Ala Gln Gly Gly Val Glu Val Leu Leu Arg 
            260                 265                 270         

His Gly Arg Ser Leu Phe Ser Trp Arg Lys Arg Arg Met Trp Gly Val 
        275                 280                 285             

Leu Leu Glu Tyr Ile Leu Ser Val Leu Trp Ala Tyr Ser Ile Val Leu 
    290                 295                 300                 

Ile Ala Val Leu Trp Ala Pro Arg Gln Phe Phe Ala Leu Pro Thr Ala 
305                 310                 315                 320 

Val Ser Ile His Gly Leu Leu Pro Gln Trp His Gly Ala Ala Met Val 
                325                 330                 335     

Leu Val Cys Leu Leu Gln Phe Ala Ser Ser Leu Ile Ile Asp Arg Arg 
            340                 345                 350         

Tyr Glu Lys Gly Ile Gly Arg Asn Tyr Phe Trp Val Ile Trp Tyr Pro 
        355                 360                 365             

Ile Ala Tyr Trp Leu Leu Ser Leu Cys Thr Thr Val Val Ala Leu Pro 
    370                 375                 380                 

Lys Thr Leu Leu Thr Arg Arg Gly Lys Arg Ala Ile Trp Val Ser Pro 
385                 390                 395                 400 

Asp Arg Gly Ile 
                

<210>   160
<211>   404
<212>   PRT
<213>   Xanthomonas oryzae pv. oryzicola BLS256

<400>   160
Phe Ala Phe Phe Tyr Pro Ile Met Met Ala Phe Phe Trp Ile Ser Gly 
                5                   10                  15      

Gly Leu Tyr Tyr Phe Leu Arg Arg Glu Arg Lys Ser Arg Pro Arg Asn 
            20                  25                  30          

Asn Pro Pro Pro Met Gly His Tyr Pro Ser Ala Ser Leu Leu Ile Pro 
        35                  40                  45              

Cys His Asn Glu Ser Glu Asn Leu Asp Asp Thr Ile Gly Ser Ala Leu 
    50                  55                  60                  

Ala Gln Arg Tyr Pro Asp Phe Glu Val Ile Ala Ile Asn Asp Gly Ser 
65                  70                  75                  80  

Arg Asp Asp Thr Gly Ala Arg Leu Asp Ile Leu Ala Ala Arg His Pro 
                85                  90                  95      

Arg Leu Arg Val Ile His Leu Asp Arg Asn Leu Gly Lys Ala Asn Ala 
            100                 105                 110         

Leu Arg Met Gly Ala Leu Ala Ala Arg Ser Glu Tyr Leu Ile Cys Ile 
        115                 120                 125             

Asp Gly Asp Ala Met Leu Gly Glu Phe Ala Met His Trp Met Val Trp 
    130                 135                 140                 

His Leu Ser Ser Ser Pro Arg Val Gly Ala Val Thr Gly Asn Pro Arg 
145                 150                 155                 160 

Ile Arg Asn Arg Ser Thr Leu Leu Gly Arg Leu Gln Val Ala Glu Phe 
                165                 170                 175     

Ser Ser Ile Ile Gly Met Ile Lys Arg Ala Gln Arg Val Tyr Gly Arg 
            180                 185                 190         

Ile Phe Thr Val Ser Gly Val Ile Ala Gly Phe Arg Arg Thr Ala Leu 
        195                 200                 205             

His Arg Ile Gly Tyr Trp Ala Asp Asp Met Met Thr Glu Asp Ile Asp 
    210                 215                 220                 

Ile Ser Trp Arg Leu Gln Leu Asp His Trp Asp Ile Arg Tyr Glu Pro 
225                 230                 235                 240 

Asn Ala Leu Cys Phe Ile Leu Met Pro Glu Thr Leu Lys Gly Leu Trp 
                245                 250                 255     

Arg Gln Arg Leu Arg Trp Ala Gln Gly Gly Val Glu Val Leu Leu Arg 
            260                 265                 270         

His Gly Arg Ser Leu Phe Ser Trp Arg Lys Arg Arg Met Trp Gly Val 
        275                 280                 285             

Leu Leu Glu Tyr Ile Leu Ser Val Leu Trp Ala Tyr Ser Ile Val Leu 
    290                 295                 300                 

Ile Ala Val Leu Trp Ala Pro Arg Gln Phe Phe Ala Leu Pro Thr Ala 
305                 310                 315                 320 

Leu Ser Ile His Gly Leu Leu Pro Gln Trp His Gly Ala Ala Met Val 
                325                 330                 335     

Leu Val Cys Leu Leu Gln Phe Ala Ser Ser Leu Ile Ile Asp Arg Arg 
            340                 345                 350         

Tyr Glu Lys Gly Ile Gly Arg Asn Tyr Phe Trp Val Ile Trp Tyr Pro 
        355                 360                 365             

Ile Ala Tyr Trp Leu Leu Ser Leu Cys Thr Thr Val Val Ala Leu Pro 
    370                 375                 380                 

Lys Thr Leu Leu Thr Arg Arg Gly Lys Arg Ala Ile Trp Val Ser Pro 
385                 390                 395                 400 

Asp Arg Gly Ile 
                

<210>   161
<211>   470
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 154

<400>   161
Met Asn Phe Ala Asn Glu Lys Phe Arg Leu Ser Leu Gly His Val Pro 
                5                   10                  15      

Ser Glu Met His Cys Ala Gln His Ile Arg Ile Glu Ala Arg Gly Ala 
            20                  25                  30          

Val Arg Glu Phe Ala Arg Ser Gly Ala Gly Thr Arg Pro Asp Arg Arg 
        35                  40                  45              

Gly Gly Ser Ser Ser Pro Val Arg Ser Lys Arg Arg Met Val His Ser 
    50                  55                  60                  

Phe Leu Phe Leu Tyr Pro Phe Val Met Ser Ile Val Trp Met Val Gly 
65                  70                  75                  80  

Gly Cys Val Tyr Ala Trp Arg Arg Glu Arg His Pro Phe Ala Asp Ser 
                85                  90                  95      

Pro Asp Leu Pro Glu Thr Pro Phe Val Ser Ile Leu Ile Pro Cys His 
            100                 105                 110         

Asn Glu Gly Asp Val Leu Glu Asp Thr Ile Gly Arg Met Leu Gln Leu 
        115                 120                 125             

Asp Tyr Pro Ala Tyr Glu Ile Val Ala Leu Asn Asp Gly Ser Thr Asp 
    130                 135                 140                 

Asp Thr Arg Ala Val Leu Glu Arg Met Ala Ala Cys Asp Ala Arg Val 
145                 150                 155                 160 

Arg Val Val Asn Leu Pro Val Gln Arg Gly Lys Ala Arg Ala Leu Asn 
                165                 170                 175     

Ala Gly Leu Val Ala Ser Arg Gly Glu Ile Leu Val Thr Val Asp Ala 
            180                 185                 190         

Asp Ala Val Leu Ala Lys Asp Ala Leu Arg Phe Leu Val Trp His Phe 
        195                 200                 205             

Val Ala Pro Gly Ser Glu Arg Val Gly Ala Val Thr Gly Asn Pro Arg 
    210                 215                 220                 

Ile Arg Asn Arg Gly Thr Leu Leu Gly Lys Ile Gln Val Leu Glu Tyr 
225                 230                 235                 240 

Ala Ser Ile Ile Gly Leu Ile Lys Arg Ala Gln Arg Val Leu Gly Lys 
                245                 250                 255     

Ile Met Thr Val Ser Gly Val Ile Ala Ala Phe Arg Lys Arg Ala Leu 
            260                 265                 270         

Val Asp Cys Gly Met Trp Asp Glu Asp Met Val Thr Asp Asp Ile Ala 
        275                 280                 285             

Val Ser Trp Lys Leu Glu Arg Arg Ala Trp Asp Ile Arg Tyr Glu Pro 
    290                 295                 300                 

Arg Ala Leu Cys Phe Met Trp Ala Pro Glu Arg Leu Arg Ser Leu Ile 
305                 310                 315                 320 

Arg Gln Arg Ala Arg Trp Ala Gln Gly Gly Val Glu Val Leu Ile Arg 
                325                 330                 335     

Asn Ala Ser Val Leu Trp Thr Trp Lys Asn Arg Arg Met Ile Pro Leu 
            340                 345                 350         

Tyr Val Glu Glu Leu Leu Gly Ile Ala Trp Ala Tyr Leu Trp Val Val 
        355                 360                 365             

Ser Leu Val Trp Thr Leu Ala Phe Asp Val Ala His Gly Ile Pro Trp 
    370                 375                 380                 

Thr Tyr Val Ala Glu Thr Gly Thr Trp Leu Gly Leu Thr Ser Leu Val 
385                 390                 395                 400 

Gln Thr Ser Val Ala Leu Trp Ile Glu Gln Arg Tyr Glu Arg Asp Ser 
                405                 410                 415     

Leu Trp Arg Tyr Tyr Phe Tyr Ala Ile Trp Tyr Pro Ala Ala Tyr Trp 
            420                 425                 430         

Met Ile Gly Ala Phe Val Val Val Trp Ala Val Pro Lys Ala Cys Trp 
        435                 440                 445             

Ala Met Trp Ala Ala Arg Arg Gly Arg Tyr Ala Thr Trp Lys Ser Pro 
    450                 455                 460                 

Asp Arg Gly Val Ser Ala 
465                 470 

<210>   162
<211>   470
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 154

<400>   162
Met Asn Phe Ala Asn Glu Lys Phe Arg Leu Ser Leu Gly His Val Pro 
                5                   10                  15      

Ser Glu Met His Cys Ala Gln His Ile Arg Ile Glu Ala Arg Gly Ala 
            20                  25                  30          

Val Arg Glu Phe Ala Arg Ser Gly Ala Gly Thr Arg Pro Asp Arg Arg 
        35                  40                  45              

Gly Gly Ser Ser Ser Pro Val Arg Ser Lys Arg Arg Met Val His Ser 
    50                  55                  60                  

Phe Leu Phe Leu Tyr Pro Phe Val Met Ser Ile Val Trp Met Val Gly 
65                  70                  75                  80  

Gly Cys Val Tyr Ala Trp Arg Arg Glu Arg His Pro Phe Ala Glu Ser 
                85                  90                  95      

Pro Asp Leu Pro Glu Thr Pro Phe Val Ser Ile Leu Ile Pro Cys His 
            100                 105                 110         

Asn Glu Gly Asp Val Leu Glu Asp Thr Ile Gly Arg Met Leu Gln Leu 
        115                 120                 125             

Asp Tyr Pro Ala Tyr Glu Ile Val Ala Leu Asn Asp Gly Ser Thr Asp 
    130                 135                 140                 

Asp Thr Arg Ala Val Leu Glu Arg Met Ala Ala Cys Asp Ala Arg Val 
145                 150                 155                 160 

Arg Val Val Asn Leu Pro Val Gln Arg Gly Lys Ala Arg Ala Leu Asn 
                165                 170                 175     

Ala Gly Leu Val Ala Ser Arg Gly Glu Ile Leu Val Thr Val Asp Ala 
            180                 185                 190         

Asp Ala Val Leu Ala Lys Asp Ala Leu Arg Phe Leu Val Trp His Phe 
        195                 200                 205             

Val Ala Pro Gly Ser Glu Arg Val Gly Ala Val Thr Gly Asn Pro Arg 
    210                 215                 220                 

Ile Arg Asn Arg Gly Thr Leu Leu Gly Lys Ile Gln Val Leu Glu Tyr 
225                 230                 235                 240 

Ala Ser Ile Ile Gly Leu Ile Lys Arg Ala Gln Arg Val Leu Gly Lys 
                245                 250                 255     

Ile Met Thr Val Ser Gly Val Ile Ala Ala Phe Arg Lys Arg Ala Leu 
            260                 265                 270         

Val Asp Cys Gly Met Trp Asp Glu Asp Met Val Thr Asp Asp Ile Ala 
        275                 280                 285             

Val Ser Trp Lys Leu Glu Arg Arg Ala Trp Asp Ile Arg Tyr Glu Pro 
    290                 295                 300                 

Arg Ala Leu Cys Phe Met Trp Ala Pro Glu Arg Leu Arg Ser Leu Ile 
305                 310                 315                 320 

Arg Gln Arg Ala Arg Trp Ala Gln Gly Gly Val Glu Val Leu Ile Arg 
                325                 330                 335     

Asn Ala Ser Val Leu Trp Thr Trp Lys Asn Arg Arg Met Ile Pro Leu 
            340                 345                 350         

Tyr Val Glu Glu Leu Leu Gly Ile Ala Trp Ala Tyr Leu Trp Val Ile 
        355                 360                 365             

Ser Leu Val Trp Thr Leu Ala Phe Asp Val Ala His Gly Ile Pro Trp 
    370                 375                 380                 

Thr Tyr Val Ala Glu Thr Gly Thr Trp Leu Gly Leu Thr Ser Leu Val 
385                 390                 395                 400 

Gln Thr Ser Val Ala Leu Trp Ile Glu Gln Arg Tyr Glu Arg Asp Ser 
                405                 410                 415     

Leu Trp Arg Tyr Tyr Phe Tyr Ala Ile Trp Tyr Pro Ala Ala Tyr Trp 
            420                 425                 430         

Met Ile Gly Ala Phe Val Val Val Trp Ala Val Pro Lys Ala Cys Trp 
        435                 440                 445             

Ala Met Trp Ala Ala Arg Arg Gly Arg Tyr Ala Thr Trp Lys Ser Pro 
    450                 455                 460                 

Asp Arg Gly Val Ser Ala 
465                 470 

<210>   163
<211>   470
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 154

<400>   163
Met Asn Phe Ala Asn Glu Lys Phe Arg Leu Ser Leu Gly His Val Pro 
                5                   10                  15      

Ser Glu Met His Cys Ala Gln His Ile Arg Ile Glu Ala Arg Gly Ala 
            20                  25                  30          

Val Arg Glu Phe Ala Arg Ser Gly Ala Gly Thr Lys Pro Asp Arg Arg 
        35                  40                  45              

Gly Gly Ser Ser Ser Pro Val Arg Ser Lys Arg Arg Met Val His Ser 
    50                  55                  60                  

Phe Leu Phe Leu Tyr Pro Phe Val Met Ser Ile Val Trp Met Val Gly 
65                  70                  75                  80  

Gly Cys Val Tyr Ala Trp Arg Arg Glu Arg His Pro Phe Ala Glu Ser 
                85                  90                  95      

Pro Asp Leu Pro Glu Thr Pro Phe Val Ser Ile Leu Ile Pro Cys His 
            100                 105                 110         

Asn Glu Gly Asp Val Leu Glu Asp Thr Ile Gly Arg Met Leu Gln Leu 
        115                 120                 125             

Asp Tyr Pro Ala Tyr Glu Ile Val Ala Leu Asn Asp Gly Ser Thr Asp 
    130                 135                 140                 

Asp Thr Arg Ala Val Leu Glu Arg Met Ala Ala Cys Asp Ala Arg Val 
145                 150                 155                 160 

Arg Val Val Asn Leu Pro Val Gln Arg Gly Lys Ala Arg Ala Leu Asn 
                165                 170                 175     

Ala Gly Leu Val Ala Ser Arg Gly Glu Ile Leu Val Thr Val Asp Ala 
            180                 185                 190         

Asp Ala Val Leu Ala Lys Asp Ala Leu Arg Phe Leu Val Trp His Phe 
        195                 200                 205             

Val Ala Pro Gly Ser Glu Arg Val Gly Ala Val Thr Gly Asn Pro Arg 
    210                 215                 220                 

Ile Arg Asn Arg Gly Thr Leu Leu Gly Lys Ile Gln Val Leu Glu Tyr 
225                 230                 235                 240 

Ala Ser Ile Ile Gly Leu Ile Lys Arg Ala Gln Arg Val Leu Gly Lys 
                245                 250                 255     

Ile Met Thr Val Ser Gly Val Ile Ala Ala Phe Arg Lys Arg Ala Leu 
            260                 265                 270         

Val Asp Cys Gly Met Trp Asp Glu Asp Met Val Thr Asp Asp Ile Ala 
        275                 280                 285             

Val Ser Trp Lys Leu Glu Arg Arg Ala Trp Asp Ile Arg Tyr Glu Pro 
    290                 295                 300                 

Arg Ala Leu Cys Phe Met Trp Ala Pro Glu Arg Leu Arg Ser Leu Ile 
305                 310                 315                 320 

Arg Gln Arg Ala Arg Trp Ala Gln Gly Gly Val Glu Val Leu Ile Arg 
                325                 330                 335     

Asn Ala Ser Val Leu Trp Thr Trp Lys Asn Arg Arg Met Ile Pro Leu 
            340                 345                 350         

Tyr Val Glu Glu Leu Leu Gly Ile Ala Trp Ala Tyr Leu Trp Val Val 
        355                 360                 365             

Ser Leu Val Trp Thr Leu Ala Phe Asp Val Ala His Gly Ile Pro Trp 
    370                 375                 380                 

Thr Tyr Val Ala Glu Thr Gly Thr Trp Leu Gly Leu Thr Ser Leu Val 
385                 390                 395                 400 

Gln Thr Ser Val Ala Leu Trp Ile Glu Gln Arg Tyr Glu Arg Asp Ser 
                405                 410                 415     

Leu Trp Arg Tyr Tyr Phe Tyr Ala Ile Trp Tyr Pro Ala Ala Tyr Trp 
            420                 425                 430         

Met Ile Gly Ala Phe Val Val Val Trp Ala Val Pro Lys Ala Cys Trp 
        435                 440                 445             

Ala Met Trp Ala Ala Arg Arg Gly Arg Tyr Ala Thr Trp Lys Ser Pro 
    450                 455                 460                 

Asp Arg Gly Val Ser Ala 
465                 470 

<210>   164
<211>   470
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 154

<400>   164
Met Asn Phe Ala Asn Glu Lys Phe Arg Leu Ser Leu Gly His Val Pro 
                5                   10                  15      

Ser Glu Met His Cys Ala Gln His Ile Arg Ile Glu Ala Arg Gly Ala 
            20                  25                  30          

Val Arg Glu Phe Ala Arg Ser Gly Ala Gly Thr Arg Pro Asp Arg Arg 
        35                  40                  45              

Gly Gly Ser Ser Ser Pro Val Arg Ser Lys Arg Arg Met Val His Ser 
    50                  55                  60                  

Phe Leu Phe Leu Tyr Pro Phe Val Met Ser Ile Val Trp Met Val Gly 
65                  70                  75                  80  

Gly Cys Val Tyr Ala Trp Arg Arg Glu Arg His Pro Phe Ala Glu Ser 
                85                  90                  95      

Pro Asp Leu Pro Glu Thr Pro Phe Val Ser Ile Leu Ile Pro Cys His 
            100                 105                 110         

Asn Glu Gly Asp Val Leu Glu Asp Thr Ile Gly Arg Met Leu Gln Leu 
        115                 120                 125             

Asp Tyr Pro Ala Tyr Glu Ile Val Ala Leu Asn Asp Gly Ser Thr Asp 
    130                 135                 140                 

Asp Thr Arg Ala Val Leu Glu Arg Met Ala Ala Cys Asp Ala Arg Val 
145                 150                 155                 160 

Arg Val Val Asn Leu Pro Val Gln Arg Gly Lys Ala Arg Ala Leu Asn 
                165                 170                 175     

Ala Gly Leu Val Ala Ser Arg Gly Glu Ile Leu Val Thr Val Asp Ala 
            180                 185                 190         

Asp Ala Val Leu Ala Lys Asp Ala Leu Arg Phe Leu Val Trp His Phe 
        195                 200                 205             

Val Ala Pro Gly Ser Glu Arg Val Gly Ala Val Thr Gly Asn Pro Arg 
    210                 215                 220                 

Ile Arg Asn Arg Gly Thr Leu Leu Gly Lys Ile Gln Val Leu Glu Tyr 
225                 230                 235                 240 

Ala Ser Ile Ile Gly Leu Ile Lys Arg Ala Gln Arg Val Leu Gly Lys 
                245                 250                 255     

Ile Met Thr Val Ser Gly Val Ile Ala Ala Phe Arg Lys Arg Ala Leu 
            260                 265                 270         

Val Asp Cys Gly Met Trp Asp Glu Asp Met Val Thr Asp Asp Ile Ala 
        275                 280                 285             

Val Ser Trp Lys Leu Glu Arg Arg Ala Trp Asp Ile Arg Tyr Glu Pro 
    290                 295                 300                 

Arg Ala Leu Cys Phe Met Trp Ala Pro Glu Arg Leu Arg Ser Leu Ile 
305                 310                 315                 320 

Arg Gln Arg Ala Arg Trp Ala Gln Gly Gly Val Glu Val Leu Ile Arg 
                325                 330                 335     

Asn Ala Ser Val Leu Trp Thr Trp Lys Asn Arg Arg Met Ile Pro Leu 
            340                 345                 350         

Tyr Val Glu Glu Leu Leu Gly Ile Ala Trp Ala Tyr Leu Trp Val Val 
        355                 360                 365             

Ser Leu Val Trp Thr Leu Ala Phe Asp Val Ala His Gly Ile Pro Trp 
    370                 375                 380                 

Thr Tyr Val Ala Glu Thr Gly Thr Trp Leu Gly Leu Thr Ser Leu Val 
385                 390                 395                 400 

Gln Thr Ser Val Ala Leu Trp Ile Glu Gln Arg Tyr Glu Arg Glu Ser 
                405                 410                 415     

Leu Trp Arg Tyr Tyr Phe Tyr Ala Ile Trp Tyr Pro Ala Ala Tyr Trp 
            420                 425                 430         

Met Ile Gly Ala Phe Val Val Val Trp Ala Val Pro Lys Ala Cys Trp 
        435                 440                 445             

Ala Met Trp Ala Ala Arg Arg Gly Arg Tyr Ala Thr Trp Lys Ser Pro 
    450                 455                 460                 

Asp Arg Gly Val Ser Ala 
465                 470 

<210>   165
<211>   470
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 154

<400>   165
Met Gln Phe Ala Asn Glu Lys Phe Arg Leu Ser Leu Gly His Val Pro 
                5                   10                  15      

Ser Glu Met His Cys Ala Gln His Ile Arg Ile Glu Ala Arg Gly Ala 
            20                  25                  30          

Val Arg Glu Phe Ala Arg Ser Gly Ala Gly Thr Arg Pro Asp Arg Arg 
        35                  40                  45              

Gly Gly Ser Ser Ser Pro Val Arg Ser Lys Arg Arg Met Val His Ser 
    50                  55                  60                  

Phe Leu Phe Leu Tyr Pro Phe Val Met Ser Ile Val Trp Met Val Gly 
65                  70                  75                  80  

Gly Cys Val Tyr Ala Trp Arg Arg Glu Arg His Pro Phe Ala Glu Ser 
                85                  90                  95      

Pro Asp Leu Pro Glu Thr Pro Phe Val Ser Ile Leu Ile Pro Cys His 
            100                 105                 110         

Asn Glu Gly Asp Val Leu Glu Asp Thr Ile Gly Arg Met Leu Gln Leu 
        115                 120                 125             

Asp Tyr Pro Ala Tyr Glu Ile Val Ala Leu Asn Asp Gly Ser Thr Asp 
    130                 135                 140                 

Asp Thr Arg Ala Val Leu Glu Arg Met Ala Ala Cys Asp Ala Arg Val 
145                 150                 155                 160 

Arg Val Val Asn Leu Pro Val Gln Arg Gly Lys Ala Arg Ala Leu Asn 
                165                 170                 175     

Ala Gly Leu Val Ala Ser Arg Gly Glu Ile Leu Val Thr Val Asp Ala 
            180                 185                 190         

Asp Ala Val Leu Ala Lys Asp Ala Leu Arg Phe Leu Val Trp His Phe 
        195                 200                 205             

Val Ala Pro Gly Ser Glu Arg Val Gly Ala Val Thr Gly Asn Pro Arg 
    210                 215                 220                 

Ile Arg Asn Arg Gly Thr Leu Leu Gly Lys Ile Gln Val Leu Glu Tyr 
225                 230                 235                 240 

Ala Ser Ile Ile Gly Leu Ile Lys Arg Ala Gln Arg Val Leu Gly Lys 
                245                 250                 255     

Ile Met Thr Val Ser Gly Val Ile Ala Ala Phe Arg Lys Arg Ala Leu 
            260                 265                 270         

Val Asp Cys Gly Met Trp Asp Glu Asp Met Val Thr Asp Asp Ile Ala 
        275                 280                 285             

Val Ser Trp Lys Leu Glu Arg Arg Ala Trp Asp Ile Arg Tyr Glu Pro 
    290                 295                 300                 

Arg Ala Leu Cys Phe Met Trp Ala Pro Glu Arg Leu Arg Ser Leu Ile 
305                 310                 315                 320 

Arg Gln Arg Ala Arg Trp Ala Gln Gly Gly Val Glu Val Leu Ile Arg 
                325                 330                 335     

Asn Ala Ser Val Leu Trp Thr Trp Lys Asn Arg Arg Met Ile Pro Leu 
            340                 345                 350         

Tyr Val Glu Glu Leu Leu Gly Ile Ala Trp Ala Tyr Leu Trp Val Val 
        355                 360                 365             

Ser Leu Val Trp Thr Leu Ala Phe Asp Val Ala His Gly Ile Pro Trp 
    370                 375                 380                 

Thr Tyr Val Ala Glu Thr Gly Thr Trp Leu Gly Leu Thr Ser Leu Val 
385                 390                 395                 400 

Gln Thr Ser Val Ala Leu Trp Ile Glu Gln Arg Tyr Glu Arg Asp Ser 
                405                 410                 415     

Leu Trp Arg Tyr Tyr Phe Tyr Ala Ile Trp Tyr Pro Ala Ala Tyr Trp 
            420                 425                 430         

Met Ile Gly Ala Phe Val Val Val Trp Ala Val Pro Lys Ala Cys Trp 
        435                 440                 445             

Ala Met Trp Ala Ala Arg Arg Gly Arg Tyr Ala Thr Trp Lys Ser Pro 
    450                 455                 460                 

Asp Arg Gly Val Ser Ala 
465                 470 

<210>   166
<211>   1413
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 155

<400>   166
ttgaacttcg ctaatgaaaa atttaggctg tcgcttgggc atgtgccgtc ggaaatgcat       60

tgcgcacaac atattcgtat cgaagctcgc ggagcggtcc gcgagttcgc gcgatccggc      120

gcagggactc ggccggatcg ccgcggtgga agctcgagtc cagtgaggag caaacggcgc      180

atggtgcatt cttttctgtt cctgtatccc tttgtcatga gcatcgtctg gatggtgggc      240

ggctgtgtct atgcctggcg gcgcgaacgc caccccttcg ccgattcccc ggacctcccc      300

gagacgccgt ttgtttccat cctcatcccc tgccacaacg aaggggatgt gctcgaagac      360

accatcggcc ggatgcttca gttggattat ccggcgtacg aaattgtcgc actgaacgac      420

ggcagcacgg acgacacgcg cgcggtgctc gaacgcatgg cggcctgcga tgcgcgagtt      480

cgcgtggtca acctgcccgt tcagcgcgga aaggcgcgcg cgctgaacgc tgggcttgtc      540

gcgtcccgag gcgagatcct cgtgaccgtg gacgcggacg ccgtgttggc gaaggacgcg      600

cttcgcttcc tcgtctggca cttcgtggcc ccgggcagcg agcgcgtcgg tgccgtgacg      660

ggcaacccgc gcattcgaaa tcgcggtacg ctgctcggaa agattcaggt gctggagtac      720

gcgagcatca tcgggctcat caagcgcgcg cagcgcgtgc tcggcaagat catgacggtc      780

tcgggcgtga ttgcggcctt tcgcaagagg gccctcgtgg actgcggcat gtgggacgag      840

gacatggtga cggatgacat cgcggtgtcc tggaagctcg agcggcgagc ctgggacatc      900

cgatacgagc cgcgagcgct ctgcttcatg tgggcgcccg agcgcctgcg gagcctcatc      960

cgccagcgcg ctcgctgggc gcagggcggc gtggaggtcc tcatccgcaa cgcctcggtc     1020

ctctggacct ggaagaatcg gcgcatgatc ccgctctatg tggaagagct cctgggcatc     1080

gcctgggcgt acctttgggt tgtgagcctc gtgtggaccc tcgcatttga cgtggcgcac     1140

ggcattccct ggacgtacgt ggcggagacg gggacgtggc tcggcctgac atcgttagtg     1200

cagacctcgg tcgccctttg gattgagcag cgatacgagc gcgactcgct ctggcgctac     1260

tatttctatg ccatctggta tccggccgcg tattggatga tcggcgcgtt cgtcgtggtc     1320

tgggcggtgc cgaaggcgtg ctgggccatg tgggcggctc ggcgcgggcg gtacgccacg     1380

tggaaaagcc cggatcgggg ggtgtcggca tga                                  1413


<210>   167
<211>   1413
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 155

<400>   167
ttgaacttcg ctaatgaaaa atttaggctg tcgcttgggc atgtgccgtc ggaaatgcat       60

tgcgcacaac atattcgtat cgaagctcgc ggagcggtcc gcgagttcgc gcgatccggc      120

gcagggactc ggccggatcg ccgcggtgga agctcgagtc cagtgaggag caaacggcgc      180

atggtgcatt cttttctgtt cctgtatccc tttgtcatga gcatcgtctg gatggtgggc      240

ggctgtgtct atgcctggcg gcgcgaacgc caccccttcg ccgaatcccc ggacctcccc      300

gagacgccgt ttgtttccat cctcatcccc tgccacaacg aaggggatgt gctcgaagac      360

accatcggcc ggatgcttca gttggattat ccggcgtacg aaattgtcgc actgaacgac      420

ggcagcacgg acgacacgcg cgcggtgctc gaacgcatgg cggcctgcga tgcgcgagtt      480

cgcgtggtca acctgcccgt tcagcgcgga aaggcgcgcg cgctgaacgc tgggcttgtc      540

gcgtcccgag gcgagatcct cgtgaccgtg gacgcggacg ccgtgttggc gaaggacgcg      600

cttcgcttcc tcgtctggca cttcgtggcc ccgggcagcg agcgcgtcgg tgccgtgacg      660

ggcaacccgc gcattcgaaa tcgcggtacg ctgctcggaa agattcaggt gctggagtac      720

gcgagcatca tcgggctcat caagcgcgcg cagcgcgtgc tcggcaagat catgacggtc      780

tcgggcgtga ttgcggcctt tcgcaagagg gccctcgtgg actgcggcat gtgggacgag      840

gacatggtga cggatgacat cgcggtgtcc tggaagctcg agcggcgagc ctgggacatc      900

cgatacgagc cgcgagcgct ctgcttcatg tgggcgcccg agcgcctgcg gagcctcatc      960

cgccagcgcg ctcgctgggc gcagggcggc gtggaggtcc tcatccgcaa cgcctcggtc     1020

ctctggacct ggaagaatcg gcgcatgatc ccgctctatg tggaagagct cctgggcatc     1080

gcctgggcgt acctttgggt tattagcctc gtgtggaccc tcgcatttga cgtggcgcac     1140

ggcattccct ggacgtacgt ggcggagacg gggacgtggc tcggcctgac atcgttagtg     1200

cagacctcgg tcgccctttg gattgagcag cgatacgagc gcgactcgct ctggcgctac     1260

tatttctatg ccatctggta tccggccgcg tattggatga tcggcgcgtt cgtcgtggtc     1320

tgggcggtgc cgaaggcgtg ctgggccatg tgggcggctc ggcgcgggcg gtacgccacg     1380

tggaaaagcc cggatcgggg ggtgtcggca tga                                  1413


<210>   168
<211>   1413
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 155

<400>   168
ttgaacttcg ctaatgaaaa atttaggctg tcgcttgggc atgtgccgtc ggaaatgcat       60

tgcgcacaac atattcgtat cgaagctcgc ggagcggtcc gcgagttcgc gcgatccggc      120

gcagggacta aaccggatcg ccgcggtgga agctcgagtc cagtgaggag caaacggcgc      180

atggtgcatt cttttctgtt cctgtatccc tttgtcatga gcatcgtctg gatggtgggc      240

ggctgtgtct atgcctggcg gcgcgaacgc caccccttcg ccgaatcccc ggacctcccc      300

gagacgccgt ttgtttccat cctcatcccc tgccacaacg aaggggatgt gctcgaagac      360

accatcggcc ggatgcttca gttggattat ccggcgtacg aaattgtcgc actgaacgac      420

ggcagcacgg acgacacgcg cgcggtgctc gaacgcatgg cggcctgcga tgcgcgagtt      480

cgcgtggtca acctgcccgt tcagcgcgga aaggcgcgcg cgctgaacgc tgggcttgtc      540

gcgtcccgag gcgagatcct cgtgaccgtg gacgcggacg ccgtgttggc gaaggacgcg      600

cttcgcttcc tcgtctggca cttcgtggcc ccgggcagcg agcgcgtcgg tgccgtgacg      660

ggcaacccgc gcattcgaaa tcgcggtacg ctgctcggaa agattcaggt gctggagtac      720

gcgagcatca tcgggctcat caagcgcgcg cagcgcgtgc tcggcaagat catgacggtc      780

tcgggcgtga ttgcggcctt tcgcaagagg gccctcgtgg actgcggcat gtgggacgag      840

gacatggtga cggatgacat cgcggtgtcc tggaagctcg agcggcgagc ctgggacatc      900

cgatacgagc cgcgagcgct ctgcttcatg tgggcgcccg agcgcctgcg gagcctcatc      960

cgccagcgcg ctcgctgggc gcagggcggc gtggaggtcc tcatccgcaa cgcctcggtc     1020

ctctggacct ggaagaatcg gcgcatgatc ccgctctatg tggaagagct cctgggcatc     1080

gcctgggcgt acctttgggt tgtgagcctc gtgtggaccc tcgcatttga cgtggcgcac     1140

ggcattccct ggacgtacgt ggcggagacg gggacgtggc tcggcctgac atcgttagtg     1200

cagacctcgg tcgccctttg gattgagcag cgatacgagc gcgactcgct ctggcgctac     1260

tatttctatg ccatctggta tccggccgcg tattggatga tcggcgcgtt cgtcgtggtc     1320

tgggcggtgc cgaaggcgtg ctgggccatg tgggcggctc ggcgcgggcg gtacgccacg     1380

tggaaaagcc cggatcgggg ggtgtcggca tga                                  1413


<210>   169
<211>   1413
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 155

<400>   169
ttgaacttcg ctaatgaaaa atttaggctg tcgcttgggc atgtgccgtc ggaaatgcat       60

tgcgcacaac atattcgtat cgaagctcgc ggagcggtcc gcgagttcgc gcgatccggc      120

gcagggactc ggccggatcg ccgcggtgga agctcgagtc cagtgaggag caaacggcgc      180

atggtgcatt cttttctgtt cctgtatccc tttgtcatga gcatcgtctg gatggtgggc      240

ggctgtgtct atgcctggcg gcgcgaacgc caccccttcg ccgaatcccc ggacctcccc      300

gagacgccgt ttgtttccat cctcatcccc tgccacaacg aaggggatgt gctcgaagac      360

accatcggcc ggatgcttca gttggattat ccggcgtacg aaattgtcgc actgaacgac      420

ggcagcacgg acgacacgcg cgcggtgctc gaacgcatgg cggcctgcga tgcgcgagtt      480

cgcgtggtca acctgcccgt tcagcgcgga aaggcgcgcg cgctgaacgc tgggcttgtc      540

gcgtcccgag gcgagatcct cgtgaccgtg gacgcggacg ccgtgttggc gaaggacgcg      600

cttcgcttcc tcgtctggca cttcgtggcc ccgggcagcg agcgcgtcgg tgccgtgacg      660

ggcaacccgc gcattcgaaa tcgcggtacg ctgctcggaa agattcaggt gctggagtac      720

gcgagcatca tcgggctcat caagcgcgcg cagcgcgtgc tcggcaagat catgacggtc      780

tcgggcgtga ttgcggcctt tcgcaagagg gccctcgtgg actgcggcat gtgggacgag      840

gacatggtga cggatgacat cgcggtgtcc tggaagctcg agcggcgagc ctgggacatc      900

cgatacgagc cgcgagcgct ctgcttcatg tgggcgcccg agcgcctgcg gagcctcatc      960

cgccagcgcg ctcgctgggc gcagggcggc gtggaggtcc tcatccgcaa cgcctcggtc     1020

ctctggacct ggaagaatcg gcgcatgatc ccgctctatg tggaagagct cctgggcatc     1080

gcctgggcgt acctttgggt tgtgagcctc gtgtggaccc tcgcatttga cgtggcgcac     1140

ggcattccct ggacgtacgt ggcggagacg gggacgtggc tcggcctgac atcgttagtg     1200

cagacctcgg tcgccctttg gattgagcag cgatacgagc gcgaatcgct ctggcgctac     1260

tatttctatg ccatctggta tccggccgcg tattggatga tcggcgcgtt cgtcgtggtc     1320

tgggcggtgc cgaaggcgtg ctgggccatg tgggcggctc ggcgcgggcg gtacgccacg     1380

tggaaaagcc cggatcgggg ggtgtcggca tga                                  1413


<210>   170
<211>   1413
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 155

<400>   170
ttgcaattcg ctaatgaaaa atttaggctg tcgcttgggc atgtgccgtc ggaaatgcat       60

tgcgcacaac atattcgtat cgaagctcgc ggagcggtcc gcgagttcgc gcgatccggc      120

gcagggactc ggccggatcg ccgcggtgga agctcgagtc cagtgaggag caaacggcgc      180

atggtgcatt cttttctgtt cctgtatccc tttgtcatga gcatcgtctg gatggtgggc      240

ggctgtgtct atgcctggcg gcgcgaacgc caccccttcg ccgaatcccc ggacctcccc      300

gagacgccgt ttgtttccat cctcatcccc tgccacaacg aaggggatgt gctcgaagac      360

accatcggcc ggatgcttca gttggattat ccggcgtacg aaattgtcgc actgaacgac      420

ggcagcacgg acgacacgcg cgcggtgctc gaacgcatgg cggcctgcga tgcgcgagtt      480

cgcgtggtca acctgcccgt tcagcgcgga aaggcgcgcg cgctgaacgc tgggcttgtc      540

gcgtcccgag gcgagatcct cgtgaccgtg gacgcggacg ccgtgttggc gaaggacgcg      600

cttcgcttcc tcgtctggca cttcgtggcc ccgggcagcg agcgcgtcgg tgccgtgacg      660

ggcaacccgc gcattcgaaa tcgcggtacg ctgctcggaa agattcaggt gctggagtac      720

gcgagcatca tcgggctcat caagcgcgcg cagcgcgtgc tcggcaagat catgacggtc      780

tcgggcgtga ttgcggcctt tcgcaagagg gccctcgtgg actgcggcat gtgggacgag      840

gacatggtga cggatgacat cgcggtgtcc tggaagctcg agcggcgagc ctgggacatc      900

cgatacgagc cgcgagcgct ctgcttcatg tgggcgcccg agcgcctgcg gagcctcatc      960

cgccagcgcg ctcgctgggc gcagggcggc gtggaggtcc tcatccgcaa cgcctcggtc     1020

ctctggacct ggaagaatcg gcgcatgatc ccgctctatg tggaagagct cctgggcatc     1080

gcctgggcgt acctttgggt tgtgagcctc gtgtggaccc tcgcatttga cgtggcgcac     1140

ggcattccct ggacgtacgt ggcggagacg gggacgtggc tcggcctgac atcgttagtg     1200

cagacctcgg tcgccctttg gattgagcag cgatacgagc gcgactcgct ctggcgctac     1260

tatttctatg ccatctggta tccggccgcg tattggatga tcggcgcgtt cgtcgtggtc     1320

tgggcggtgc cgaaggcgtg ctgggccatg tgggcggctc ggcgcgggcg gtacgccacg     1380

tggaaaagcc cggatcgggg ggtgtcggca tga                                  1413


<210>   171
<211>   366
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   171
Met Ser Ala Lys Thr Glu Asn Thr Trp Ser Leu Cys Met Ile Val Lys 
                5                   10                  15      

Asp Glu Glu Ala Val Leu Asp Arg Cys Leu Gln Ser Ile Ala Asp Ile 
            20                  25                  30          

Val Asp Glu Ile Val Ile Val Asp Thr Gly Ser Gln Asp Arg Thr Gln 
        35                  40                  45              

Glu Ile Ala Arg Lys Tyr Thr Asp Leu Val Phe Asp Phe Glu Trp Val 
    50                  55                  60                  

Asp Asp Phe Ser Glu Ala Arg Asn Glu Ser Phe Arg His Ala Ser Met 
65                  70                  75                  80  

Asp Tyr Val Leu Trp Leu Asp Ala Asp Asp Val Val Ser Asp Val Asp 
                85                  90                  95      

Arg Ile Lys Leu Ala Glu Phe Lys Lys Asn Leu Ser Ser Asp Val Asp 
            100                 105                 110         

Ala Val Thr Met Trp Tyr His Leu Ala Phe Gln Gly Asp Gln Pro Thr 
        115                 120                 125             

Val Ser Ser Arg Leu Val Arg Leu Val Lys Arg Ser Arg Gly Phe Val 
    130                 135                 140                 

Trp Arg Gly Arg Val His Glu Tyr Leu Glu Ile Asn Gly Asn Ile Leu 
145                 150                 155                 160 

Asn Ser Asp Ile Ala Ile Ile His Arg Pro Val Glu His Asp Ala Ala 
                165                 170                 175     

Arg Asn Leu Arg Ile Tyr Glu Lys Lys Leu Ala Leu Gly Glu Asp Phe 
            180                 185                 190         

Ser Pro Arg Asp Met Leu Tyr Tyr Ala Asn Glu Leu Leu Asp His Ala 
        195                 200                 205             

Gln Tyr Glu Lys Ala Val Gln Trp Tyr Lys Arg Phe Leu Ala Thr Gly 
    210                 215                 220                 

Gln Cys Trp Lys Glu Asp Ala Ile Thr Ala Cys Phe Lys Leu Ala Glu 
225                 230                 235                 240 

Cys Phe Arg Ala Met Asn Gln Pro Glu Gln Ser Lys Gln Ala Val Leu 
                245                 250                 255     

His Ser Phe Leu Tyr Asp Thr Pro Arg Ala Glu Ala Cys Cys Arg Ile 
            260                 265                 270         

Gly Tyr Gly Tyr Leu Glu Glu Gly Lys Ile Asp Gln Ala Ile Phe Trp 
        275                 280                 285             

Tyr Asp Leu Ala Thr Lys Cys Arg Arg Pro Ala Asn Phe Val Gly Phe 
    290                 295                 300                 

Val Asn His Ala Cys Glu Thr Trp Leu Pro His Ile Gln Leu Cys Val 
305                 310                 315                 320 

Cys Tyr Ser Arg Leu Gly Gln Tyr Arg Lys Ala Tyr Asp His Asn Glu 
                325                 330                 335     

Arg Ala Ala Glu Tyr Leu Gly Glu Asp Pro Met Ile Val His Asn Arg 
            340                 345                 350         

Ser Val Leu Arg Ala Trp Met Asp Gly Glu Leu Glu Lys Pro 
        355                 360                 365     

<210>   172
<211>   1101
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   172
gtgtccgcta aaacggaaaa tacttggagc ttatgtatga tcgtgaaaga tgaggaggct       60

gtactggatc gctgtctcca atcgattgcc gacattgtcg atgaaatcgt gatagttgat      120

acaggttcgc aagacaggac ccaagagatc gctcgcaaat acacagatct ggtgttcgat      180

tttgagtggg tggatgattt cagcgaggcg cgcaacgaat cgttccggca cgccagtatg      240

gattacgtcc tctggctaga cgccgacgac gttgtgtcag atgtagatcg aatcaaactg      300

gcagaattca agaaaaacct ttcttccgac gtggacgcag tgacaatgtg gtatcacctc      360

gcatttcaag gtgatcagcc gaccgtcagt tctcgtctcg ttcgcctcgt gaaacgatcg      420

cgcggttttg tttggcgggg ccgcgtccat gaatatcttg aaattaacgg caacatcctc      480

aacagcgaca tcgcaatcat ccatcgccct gtcgagcatg atgccgctcg caatcttcgc      540

atctacgaga agaagctcgc gcttggcgaa gatttcagcc cacgcgacat gctctactac      600

gccaatgagc tgctggatca tgcacaatac gagaaggctg tacaatggta caagcggttt      660

ttagcaacag gacaatgttg gaaagaggac gccatcacag cttgcttcaa gctcgccgaa      720

tgctttcgtg cgatgaatca accggagcaa agtaagcaag ctgtgttaca ctcgttcctg      780

tacgatacgc cgcgagccga agcgtgttgt cgtatcgggt atggttactt ggaagaggga      840

aagatcgatc aggccatctt ttggtatgat ctagcaacca aatgcaggcg tccagccaat      900

tttgtgggat ttgtcaacca tgcatgtgaa acctggttac cccatattca actttgtgtg      960

tgttatagcc ggctcggcca atacaggaaa gcttatgatc ataacgaacg agccgcggag     1020

tacctaggtg aagatccgat gatcgtccac aatcgttctg tattgcgagc ctggatggat     1080

ggcgaactcg agaaaccgta a                                               1101


<210>   173
<211>   356
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   173
Thr Ile Ser Leu Cys Met Ile Val Lys Asn Glu Glu Asp Val Leu Ala 
                5                   10                  15      

Arg Cys Leu Asp Ser Val Gln His Leu Val Asp Glu Ile Val Ile Val 
            20                  25                  30          

Asp Thr Gly Ser Thr Asp Arg Thr Lys Glu Ile Ala Arg Ser Tyr Thr 
        35                  40                  45              

Ala Arg Val Ile Asp Phe Pro Trp Ser Asp Asp Phe Ser Ala Ala Arg 
    50                  55                  60                  

Asn Phe Ser Phe Ser His Ala Thr Met Asp Tyr Ile Phe Trp Leu Asp 
65                  70                  75                  80  

Ala Asp Asp Ile Leu Pro Ala Glu Glu Gln Thr Lys Phe Leu Thr Leu 
                85                  90                  95      

Lys Arg Thr Leu Ser Ser Asp Ile Asp Ser Val Thr Met Ile Tyr Ser 
            100                 105                 110         

Leu Ala Gln Asp Glu Tyr Gly Lys Thr Ile Ser Ser Val Arg Arg Asn 
        115                 120                 125             

Arg Leu Val Lys Arg Ser Ser Gly Phe Arg Trp His Gly Met Val His 
    130                 135                 140                 

Glu Tyr Leu Glu Val Trp Gly Thr Ile Leu Asn Ser Asp Ile Thr Ile 
145                 150                 155                 160 

Ile His Gln Pro Asn Arg Cys Ala Ser Asp Arg Asn Leu Gln Ile Tyr 
                165                 170                 175     

Glu Lys Gln Leu Ala Gln Gly Lys Glu Phe Ser Pro Arg Asp Leu Phe 
            180                 185                 190         

Tyr Phe Ala Asn Glu Leu Phe Asp His Gln Gln Tyr Glu Arg Ala Ile 
        195                 200                 205             

Gln Tyr Tyr Glu Gln Phe Leu Gln Thr Lys Lys Gly Trp Val Glu Asp 
    210                 215                 220                 

Cys Ile Ala Ala Cys Gly Lys Val Ala Asp Cys Phe Asp Ala Leu Gly 
225                 230                 235                 240 

Asp Glu Glu Gln Ala Leu Arg Tyr Ala Leu Arg Ser Phe Glu Tyr Asp 
                245                 250                 255     

Thr Pro Arg Ala Glu Cys Cys Cys Arg Leu Gly Tyr Tyr Phe Leu Gln 
            260                 265                 270         

Arg Lys Gln Tyr Arg Leu Ala Ala Phe Trp Tyr His Leu Ala Thr Gln 
        275                 280                 285             

Leu Thr Met Pro Ser Asp Ser Trp Gly Phe Val His His Ala Cys Trp 
    290                 295                 300                 

Thr Trp Leu Pro His Leu Gln Leu Cys Val Cys Tyr Phe Tyr Met Gly 
305                 310                 315                 320 

Glu Tyr Glu Leu Ala Tyr Gln His Asn Glu Lys Ala Lys Gln Tyr Val 
                325                 330                 335     

Pro His His Pro Ala Val Leu His Asn Glu Cys Leu Leu Gln Ser Ile 
            340                 345                 350         

Leu Ala Ala Glu 
        355     

<210>   174
<211>   347
<212>   PRT
<213>   Desulfitobacterium hafniense Y51

<400>   174
Ser Leu Cys Met Ile Val Arg Asn Glu Glu Lys Thr Ile Ala Arg Cys 
                5                   10                  15      

Leu Asp Ser Val Cys Asp Ile Ala Asp Glu Ile Ile Ile Val Asp Thr 
            20                  25                  30          

Gly Ser Thr Asp Arg Thr Lys Glu Ile Val Ala Arg Tyr Thr Asp Lys 
        35                  40                  45              

Ile Phe Asp Phe Ala Trp Ile Asp Asp Phe Ala Ala Ala Arg Asn Tyr 
    50                  55                  60                  

Ala Phe Ser Leu Gly Thr Lys Glu Tyr Leu Leu Trp Leu Asp Ala Asp 
65                  70                  75                  80  

Asp Val Ile Leu Glu Ser Asp Arg Leu Lys Phe His Asn Leu Lys Lys 
                85                  90                  95      

Asn Leu Asn Pro Ser Ile Asp Val Val Asn Met His Tyr Leu Leu Ala 
            100                 105                 110         

Phe Asp Ser Ser Glu Asn Pro Thr Phe Thr Leu Arg Arg Asn Arg Leu 
        115                 120                 125             

Val Arg Arg Gly Lys Asn Phe Arg Trp Lys Gly Ala Val His Glu Tyr 
    130                 135                 140                 

Leu Glu Val Ser Gly Asn Ile Met Asn Ser Asp Ile Ala Ile Ala His 
145                 150                 155                 160 

Lys Ser Glu Glu His Asp Ser Glu Arg Asn Leu Arg Ile Tyr Glu Lys 
                165                 170                 175     

Arg Leu Glu Gln Gly Glu Glu Phe Ser Pro Arg Asp Leu Tyr Tyr Phe 
            180                 185                 190         

Ala Asn Glu Leu Tyr Asp His Lys Gln Tyr Glu Lys Ala Val Glu Tyr 
        195                 200                 205             

Tyr Glu Lys Phe Leu Asn Thr Glu Lys Gly Trp Val Glu Asp Asn Ile 
    210                 215                 220                 

Ser Ala Cys Gly Lys Leu Ala Asp Ile Tyr Lys Leu Leu Gly Asp Ser 
225                 230                 235                 240 

Ala Asn Ala Gln Ala Tyr Leu Tyr Lys Ser Phe Asp Tyr Asp Thr Pro 
                245                 250                 255     

Arg Ala Glu Phe Cys Cys Arg Ile Gly Phe Asn His Leu Asn Ala Gly 
            260                 265                 270         

Lys Tyr Gln Gln Ala Ile Phe Trp Tyr Lys Leu Ala Ser Glu Leu Glu 
        275                 280                 285             

Lys Pro Thr Asn Ser Trp Gly Pro Lys Ser Glu Ala Cys Trp Thr Tyr 
    290                 295                 300                 

Leu Pro His Leu Gln Leu Cys Val Cys Tyr Asp Arg Leu Gly Met His 
305                 310                 315                 320 

Glu Leu Ala Tyr Lys His Asn Glu Ile Ala Arg Asp Tyr Arg Pro Asp 
                325                 330                 335     

Asn Pro Gln Ile Leu His Asn Lys Lys Tyr Leu 
            340                 345         

<210>   175
<211>   355
<212>   PRT
<213>   Clostridium kluyveri DSM 555

<400>   175
Lys Asp Ser Ile Thr Val Ser Leu Cys Met Ile Val Lys Asn Glu Glu 
                5                   10                  15      

Asp Thr Ile Gly Arg Cys Leu Asp Ser Val Lys Asp Val Ile Asp Glu 
            20                  25                  30          

Phe Ile Ile Val Asp Thr Gly Ser Ser Asp Asn Thr Lys Asp Val Ile 
        35                  40                  45              

Lys Lys Tyr Thr Asp Asn Ile Tyr Asp Phe Glu Trp Ile Asp Asp Phe 
    50                  55                  60                  

Ser Ala Ala Arg Asn Phe Ala Phe Ser Lys Ala Thr Lys Asp Tyr Ile 
65                  70                  75                  80  

Phe Trp Leu Asp Ala Asp Asp Val Leu Leu Pro Glu Asp Val Glu Lys 
                85                  90                  95      

Phe Lys Ala Leu Lys Lys Asn Leu Asp Thr Ser Ile Asp Ser Val Thr 
            100                 105                 110         

Met Arg Tyr Asn Val Ser Phe Asp Glu Tyr Ser Asn Val Thr Thr Ser 
        115                 120                 125             

Tyr Arg Arg Asn Arg Leu Val Lys Lys Glu Lys Asn Phe Lys Trp Ile 
    130                 135                 140                 

Gly Phe Val His Glu Tyr Leu Glu Val Tyr Gly Asn Ile Ile Asn Ser 
145                 150                 155                 160 

Glu Ile Ser Val Thr His Lys Lys Ile Asn Tyr Ser Pro Asn Arg Asn 
                165                 170                 175     

Leu Glu Ile Phe Gln Asn Lys Leu Lys Glu Gly Val Glu Phe Thr Pro 
            180                 185                 190         

Arg Asp Ile Leu Tyr Tyr Gly Asn Glu Leu Tyr Glu His Arg Met Phe 
        195                 200                 205             

Glu Asp Ala Leu Lys Tyr Tyr Asn Asp Phe Leu Asp Ser Lys Arg Gly 
    210                 215                 220                 

Trp Tyr Glu Asp Asn Ile His Val Cys Gly Lys Ile Cys Asp Tyr Tyr 
225                 230                 235                 240 

Gln Ser Ile Asn Asn Gly Glu Glu Cys Arg Lys Tyr Ala Phe Lys Ser 
                245                 250                 255     

Phe Glu Tyr Asp Ser Pro Arg Ala Glu Ala Cys Cys Arg Leu Gly Phe 
            260                 265                 270         

Ser Phe Leu Gln Glu Asn Lys Ile Asn Gln Ala Ile Phe Trp Tyr Glu 
        275                 280                 285             

Thr Ala Ala Asn Leu Lys Lys Pro Ile Asn Ser Leu Gly Phe Phe Ser 
    290                 295                 300                 

Asp Ala Cys Trp Thr Trp Leu Pro His Leu Gln Leu Cys Val Cys Tyr 
305                 310                 315                 320 

Asp Arg Ile Gly Lys His Gln Leu Ala Tyr Glu His Asn Glu Ile Ala 
                325                 330                 335     

Gly Lys Phe Arg Pro Asn Asp Lys Lys Ile Leu Tyr Asn Arg Asn Tyr 
            340                 345                 350         

Phe Gln Ser 
        355 

<210>   176
<211>   351
<212>   PRT
<213>   Clostridium beijerinckii NCIMB 8052

<400>   176
Thr Ile Ser Leu Cys Met Ile Val Lys Asn Glu Glu Asp Val Ile Ala 
                5                   10                  15      

Asn Cys Leu Glu Ser Val Lys Asp Ile Val Asp Glu Met Ile Ile Val 
            20                  25                  30          

Asp Thr Gly Ser Asp Asp Lys Thr Lys Lys Ile Val Lys Arg Tyr Thr 
        35                  40                  45              

Asp Lys Ile Tyr Asp Phe Lys Trp Ile Asp Asp Phe Ser Ala Ala Arg 
    50                  55                  60                  

Asn Phe Ala Phe Ser Lys Ala Thr Lys Asp Tyr Ile Leu Trp Leu Asp 
65                  70                  75                  80  

Ala Asp Asp Val Val Leu Pro Glu Asp Gly Glu Lys Phe Lys Asp Leu 
                85                  90                  95      

Lys Glu Thr Leu Asp Pro Thr Val Asp Ser Val Thr Ala Lys Tyr Asn 
            100                 105                 110         

Thr Ala Phe Asp Glu Tyr Gly Asn Val Thr Ala Ser Tyr Arg Arg Asn 
        115                 120                 125             

Arg Leu Val Lys Arg Ser Asn Asn Phe Gln Trp Phe Gly Phe Val His 
    130                 135                 140                 

Glu Tyr Leu Ala Val Gly Gly Asn Ile Ile Asn Ser Glu Ile Ala Ile 
145                 150                 155                 160 

Thr His Arg Lys Leu Lys Gln Thr Pro Lys Arg Asn Leu Glu Ile Tyr 
                165                 170                 175     

Gln Asn Lys Leu Lys Glu Gly Val Val Phe Thr Pro Arg Asp Ile Leu 
            180                 185                 190         

Tyr Tyr Gly Asn Glu Leu Tyr Asp His Arg Met Phe Asp Glu Ala Leu 
        195                 200                 205             

Gln Tyr Tyr Asn Lys Phe Leu Asp Ser Lys Gln Gly Trp Phe Glu Asp 
    210                 215                 220                 

Asn Ile Arg Val Cys Glu Lys Ile Cys Asp Tyr Tyr Gln Ser Ile Asp 
225                 230                 235                 240 

Lys Val Glu Asp Gly Arg Arg Tyr Ala Phe Arg Ser Phe Glu Tyr Asp 
                245                 250                 255     

Thr Pro Arg Ala Glu Ala Cys Cys Lys Ile Gly Phe Ser Phe Leu His 
            260                 265                 270         

Glu Lys Lys Tyr Lys Gln Ser Ala Phe Trp Tyr Glu Gln Ala Thr Lys 
        275                 280                 285             

Leu Glu Lys Pro Lys Asp Ser Trp Gly Phe Phe Asn Asp Ala Cys Trp 
    290                 295                 300                 

Thr Trp Leu Pro His Leu Gln Leu Cys Val Cys Tyr Asp Arg Leu Gly 
305                 310                 315                 320 

Asp His Asn Leu Ala Tyr Glu His Asn Glu Ile Ala Ala Lys Phe Arg 
                325                 330                 335     

Pro Asn Asp Ser Arg Ile Leu Tyr Asn Arg Asn Tyr Phe Lys Ser 
            340                 345                 350     

<210>   177
<211>   345
<212>   PRT
<213>   Bacillus weihenstephanensis KBAB4

<400>   177
Thr Ile Ser Leu Cys Met Ile Val Lys Asp Glu Glu Gln Thr Ile Ser 
                5                   10                  15      

Lys Cys Leu Glu Ser Val Lys Ser Val Val Asp Glu Ile Ile Ile Val 
            20                  25                  30          

Asp Thr Gly Ser Thr Asp Gly Thr Lys Glu Ile Val Lys Lys Tyr Asp 
        35                  40                  45              

Ala Lys Val Tyr Asp Phe Gln Trp Ile Glu Asp Phe Ser Ala Ala Arg 
    50                  55                  60                  

Asn Phe Ala Phe Ser Lys Ala Thr Lys Glu Tyr Ile Leu Trp Leu Asp 
65                  70                  75                  80  

Ala Asp Asp Ile Ile Asp Thr Glu Asp Ile Lys Lys Leu Leu Gln Leu 
                85                  90                  95      

Lys His Thr Leu Asp Arg Ser Thr Asp Ala Val Ser Met Lys Tyr Tyr 
            100                 105                 110         

Leu Thr Phe Asp Ile Glu Gly Asn Pro Thr His Ser Leu Arg Arg Tyr 
        115                 120                 125             

Arg Leu Val Asn Arg Ser Lys Asn Phe Gln Trp Tyr Gly Phe Val His 
    130                 135                 140                 

Glu Tyr Leu Glu Val Tyr Gly Asn Leu Ile Asn Ser Asp Val Gly Val 
145                 150                 155                 160 

Ser His Lys Lys Glu Lys Ala Tyr Thr Asn Arg Asn Leu Lys Ile Tyr 
                165                 170                 175     

Glu Lys His Leu Glu Ser Gly Lys Glu Phe Ser Pro Arg Asp Val Tyr 
            180                 185                 190         

Tyr Tyr Ala Asn Glu Cys Lys Asp His Arg Leu Phe Asp Lys Ala Val 
        195                 200                 205             

Lys Gly Tyr Ser Arg Phe Leu Asp Glu Glu Lys Gly Trp Val Glu Asp 
    210                 215                 220                 

Asn Ile Gln Ala Cys Leu Lys Arg Ala Glu Cys Tyr Leu Glu Leu Gly 
225                 230                 235                 240 

Asp Leu Lys Lys Ser Ile Gln Ser Cys Leu Gln Ser Phe Thr Tyr Asp 
                245                 250                 255     

Thr Pro Arg Gly Glu Leu Cys Cys His Leu Gly Arg Val Phe Leu Gln 
            260                 265                 270         

Gln Gly Glu Tyr Ser Lys Ala Ile Tyr Trp Tyr His Ala Ala Ile Asp 
        275                 280                 285             

Gly Pro Arg Pro Lys Asp Ser Pro Phe Val Arg Glu Glu Cys His Thr 
    290                 295                 300                 

Trp Leu Pro His Ile Gln Leu Cys Ile Cys Tyr Asp Arg Ile Lys Glu 
305                 310                 315                 320 

Tyr Glu Lys Ala Ile Tyr His Asn Glu Gln Ala Ala Leu Phe Ile Pro 
                325                 330                 335     

Asn Asn Pro Ser Ile Glu Tyr Asn Arg 
            340                 345 

<210>   178
<211>   366
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 171

<400>   178
Met Ser Ala Lys Thr Glu Asn Thr Trp Ser Leu Cys Met Ile Val Lys 
                5                   10                  15      

Asp Glu Glu Ala Val Leu Asp Arg Cys Leu Gln Ser Ile Ala Asp Ile 
            20                  25                  30          

Val Asp Glu Ile Val Ile Val Asp Thr Gly Ser Gln Asp Arg Thr Gln 
        35                  40                  45              

Glu Ile Ala Arg Lys Tyr Thr Asp Leu Val Phe Asp Phe Glu Trp Val 
    50                  55                  60                  

Asp Asp Phe Ser Glu Ala Arg Asn Glu Ser Phe Arg His Ala Ser Met 
65                  70                  75                  80  

Asp Tyr Val Leu Trp Leu Asp Ala Asp Asp Val Val Ser Asp Val Asp 
                85                  90                  95      

Arg Ile Lys Leu Ala Glu Phe Lys Lys Asn Leu Ser Ser Asp Val Asp 
            100                 105                 110         

Ala Val Thr Met Trp Tyr His Leu Ala Phe Gln Gly Asp Gln Pro Thr 
        115                 120                 125             

Val Ser Ser Arg Leu Val Arg Leu Val Lys Arg Ser Arg Gly Phe Val 
    130                 135                 140                 

Trp Arg Gly Arg Val His Glu Tyr Leu Glu Ile Asn Gly Asn Ile Leu 
145                 150                 155                 160 

Asn Ser Asp Ile Ala Ile Ile His Arg Pro Val Glu His Asp Ala Ala 
                165                 170                 175     

Arg Asn Leu Arg Ile Tyr Glu Lys Lys Leu Ala Leu Gly Glu Asp Phe 
            180                 185                 190         

Ser Pro Arg Asp Met Leu Tyr Tyr Ala Asn Glu Leu Leu Asp His Ala 
        195                 200                 205             

Gln Tyr Glu Lys Ala Val Gln Trp Tyr Lys Arg Phe Leu Ala Thr Gly 
    210                 215                 220                 

Gln Cys Trp Lys Glu Asp Ala Ile Thr Ala Cys Phe Lys Leu Ala Glu 
225                 230                 235                 240 

Cys Phe Arg Ala Met Asn Gln Pro Glu Gln Ser Lys Gln Ala Val Leu 
                245                 250                 255     

His Ser Phe Leu Tyr Asp Thr Pro Arg Ala Glu Ala Cys Cys Arg Ile 
            260                 265                 270         

Gly Tyr Gly Tyr Leu Glu Glu Gly Lys Ile Asp Gln Ala Ile Phe Trp 
        275                 280                 285             

Tyr Asp Leu Ala Thr Lys Cys Arg Arg Pro Ala Asn Phe Val Gly Phe 
    290                 295                 300                 

Val Asn His Ala Cys Glu Thr Trp Leu Pro His Ile Gln Leu Cys Val 
305                 310                 315                 320 

Cys Tyr Ser Arg Leu Gly Asn Tyr Arg Lys Ala Tyr Asp His Asn Glu 
                325                 330                 335     

Arg Ala Ala Glu Tyr Leu Gly Glu Asp Pro Met Ile Val His Asn Arg 
            340                 345                 350         

Ser Val Leu Arg Ala Trp Met Asp Gly Glu Leu Glu Lys Pro 
        355                 360                 365     

<210>   179
<211>   366
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 171

<400>   179
Met Ser Ala Lys Thr Glu Asn Thr Trp Ser Leu Cys Met Ile Val Lys 
                5                   10                  15      

Asp Glu Glu Ala Val Leu Asp Arg Cys Leu Gln Ser Ile Ala Asp Ile 
            20                  25                  30          

Val Asp Glu Ile Val Ile Val Asp Thr Gly Ser Gln Asp Arg Thr Gln 
        35                  40                  45              

Glu Ile Ala Arg Lys Tyr Thr Asp Leu Val Phe Asp Phe Glu Trp Val 
    50                  55                  60                  

Asp Asp Phe Ser Glu Ala Arg Asn Glu Ser Phe Arg His Ala Ser Met 
65                  70                  75                  80  

Asp Tyr Val Leu Trp Leu Asp Ala Asp Asp Val Val Ser Asp Val Asp 
                85                  90                  95      

Arg Ile Lys Leu Ala Glu Phe Lys Lys Asn Leu Ser Ser Asp Val Asp 
            100                 105                 110         

Ala Val Thr Met Trp Tyr His Leu Ala Phe Gln Gly Asp Gln Pro Thr 
        115                 120                 125             

Val Ser Ser Arg Ile Val Arg Leu Val Lys Arg Ser Arg Gly Phe Val 
    130                 135                 140                 

Trp Arg Gly Arg Val His Glu Tyr Leu Glu Ile Asn Gly Asn Ile Leu 
145                 150                 155                 160 

Asn Ser Asp Ile Ala Ile Ile His Arg Pro Val Glu His Asp Ala Ala 
                165                 170                 175     

Arg Asn Leu Arg Ile Tyr Glu Lys Lys Leu Ala Leu Gly Glu Asp Phe 
            180                 185                 190         

Ser Pro Arg Asp Met Leu Tyr Tyr Ala Asn Glu Leu Leu Asp His Ala 
        195                 200                 205             

Gln Tyr Glu Lys Ala Val Gln Trp Tyr Lys Arg Phe Leu Ala Thr Gly 
    210                 215                 220                 

Gln Cys Trp Lys Glu Asp Ala Ile Thr Ala Cys Phe Lys Leu Ala Glu 
225                 230                 235                 240 

Cys Phe Arg Ala Met Asn Gln Pro Glu Gln Ser Lys Gln Ala Val Leu 
                245                 250                 255     

His Ser Phe Leu Tyr Asp Thr Pro Arg Ala Glu Ala Cys Cys Arg Ile 
            260                 265                 270         

Gly Tyr Gly Tyr Leu Glu Glu Gly Lys Ile Asp Gln Ala Ile Phe Trp 
        275                 280                 285             

Tyr Asp Leu Ala Thr Lys Cys Arg Arg Pro Ala Asn Phe Val Gly Phe 
    290                 295                 300                 

Val Asn His Ala Cys Glu Thr Trp Leu Pro His Ile Gln Leu Cys Val 
305                 310                 315                 320 

Cys Tyr Ser Arg Leu Gly Gln Tyr Arg Lys Ala Tyr Asp His Asn Glu 
                325                 330                 335     

Arg Ala Ala Glu Tyr Leu Gly Glu Asp Pro Met Ile Val His Asn Arg 
            340                 345                 350         

Ser Val Leu Arg Ala Trp Met Asp Gly Glu Leu Glu Lys Pro 
        355                 360                 365     

<210>   180
<211>   366
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 171

<400>   180
Met Ser Ala Lys Thr Glu Asn Thr Trp Ser Leu Cys Met Ile Val Lys 
                5                   10                  15      

Asp Glu Glu Ala Val Leu Asp Arg Cys Leu Gln Ser Ile Ala Asp Ile 
            20                  25                  30          

Val Asp Glu Ile Val Ile Val Asp Thr Gly Ser Gln Asp Arg Thr Gln 
        35                  40                  45              

Glu Ile Ala Arg Lys Tyr Thr Asp Leu Val Phe Asp Phe Glu Trp Val 
    50                  55                  60                  

Asp Asp Phe Ser Glu Ala Arg Asn Glu Ser Phe Arg His Ala Ser Met 
65                  70                  75                  80  

Asp Tyr Val Leu Trp Leu Asp Ala Asp Asp Val Val Ser Asp Val Asp 
                85                  90                  95      

Arg Ile Lys Leu Ala Glu Phe Lys Lys Asn Leu Ser Ser Asp Val Asp 
            100                 105                 110         

Ala Val Thr Met Trp Tyr His Leu Ala Phe Gln Gly Asp Asn Pro Thr 
        115                 120                 125             

Val Ser Ser Arg Leu Val Arg Leu Val Lys Arg Ser Arg Gly Phe Val 
    130                 135                 140                 

Trp Arg Gly Arg Val His Glu Tyr Leu Glu Ile Asn Gly Asn Ile Leu 
145                 150                 155                 160 

Asn Ser Asp Ile Ala Ile Ile His Arg Pro Val Glu His Asp Ala Ala 
                165                 170                 175     

Arg Asn Leu Arg Ile Tyr Glu Lys Lys Leu Ala Leu Gly Glu Asp Phe 
            180                 185                 190         

Ser Pro Arg Asp Met Leu Tyr Tyr Ala Asn Glu Leu Leu Asp His Ala 
        195                 200                 205             

Gln Tyr Glu Lys Ala Val Gln Trp Tyr Lys Arg Phe Leu Ala Thr Gly 
    210                 215                 220                 

Gln Cys Trp Lys Glu Asp Ala Ile Thr Ala Cys Phe Lys Leu Ala Glu 
225                 230                 235                 240 

Cys Phe Arg Ala Met Asn Gln Pro Glu Gln Ser Lys Gln Ala Val Leu 
                245                 250                 255     

His Ser Phe Leu Tyr Asp Thr Pro Arg Ala Glu Ala Cys Cys Arg Ile 
            260                 265                 270         

Gly Tyr Gly Tyr Leu Glu Glu Gly Lys Ile Asp Gln Ala Ile Phe Trp 
        275                 280                 285             

Tyr Asp Leu Ala Thr Lys Cys Arg Arg Pro Ala Asn Phe Val Gly Phe 
    290                 295                 300                 

Val Asn His Ala Cys Glu Thr Trp Leu Pro His Ile Gln Leu Cys Val 
305                 310                 315                 320 

Cys Tyr Ser Arg Leu Gly Gln Tyr Arg Lys Ala Tyr Asp His Asn Glu 
                325                 330                 335     

Arg Ala Ala Glu Tyr Leu Gly Glu Asp Pro Met Ile Val His Asn Arg 
            340                 345                 350         

Ser Val Leu Arg Ala Trp Met Asp Gly Glu Leu Glu Lys Pro 
        355                 360                 365     

<210>   181
<211>   366
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 171

<400>   181
Met Ser Ala Lys Thr Glu Asn Thr Trp Ser Leu Cys Met Ile Val Lys 
                5                   10                  15      

Asp Glu Glu Ala Val Leu Asp Arg Cys Leu Gln Ser Ile Ala Asp Ile 
            20                  25                  30          

Val Asp Glu Ile Val Ile Val Asp Thr Gly Ser Gln Asp Arg Thr Gln 
        35                  40                  45              

Glu Ile Ala Arg Lys Tyr Thr Asp Leu Val Phe Asp Phe Glu Trp Val 
    50                  55                  60                  

Asp Asp Phe Ser Glu Ala Arg Asn Glu Ser Phe Arg His Ala Ser Met 
65                  70                  75                  80  

Asp Tyr Val Leu Trp Leu Asp Ala Asp Asp Val Val Ser Asp Val Asp 
                85                  90                  95      

Arg Ile Lys Leu Ala Glu Phe Lys Lys Asn Leu Ser Ser Glu Val Asp 
            100                 105                 110         

Ala Val Thr Met Trp Tyr His Leu Ala Phe Gln Gly Asp Gln Pro Thr 
        115                 120                 125             

Val Ser Ser Arg Leu Val Arg Leu Val Lys Arg Ser Arg Gly Phe Val 
    130                 135                 140                 

Trp Arg Gly Arg Val His Glu Tyr Leu Glu Ile Asn Gly Asn Ile Leu 
145                 150                 155                 160 

Asn Ser Asp Ile Ala Ile Ile His Arg Pro Val Glu His Asp Ala Ala 
                165                 170                 175     

Arg Asn Leu Arg Ile Tyr Glu Lys Lys Leu Ala Leu Gly Glu Asp Phe 
            180                 185                 190         

Ser Pro Arg Asp Met Leu Tyr Tyr Ala Asn Glu Leu Leu Asp His Ala 
        195                 200                 205             

Gln Tyr Glu Lys Ala Val Gln Trp Tyr Lys Arg Phe Leu Ala Thr Gly 
    210                 215                 220                 

Gln Cys Trp Lys Glu Asp Ala Ile Thr Ala Cys Phe Lys Leu Ala Glu 
225                 230                 235                 240 

Cys Phe Arg Ala Met Asn Gln Pro Glu Gln Ser Lys Gln Ala Val Leu 
                245                 250                 255     

His Ser Phe Leu Tyr Asp Thr Pro Arg Ala Glu Ala Cys Cys Arg Ile 
            260                 265                 270         

Gly Tyr Gly Tyr Leu Glu Glu Gly Lys Ile Asp Gln Ala Ile Phe Trp 
        275                 280                 285             

Tyr Asp Leu Ala Thr Lys Cys Arg Arg Pro Ala Asn Phe Val Gly Phe 
    290                 295                 300                 

Val Asn His Ala Cys Glu Thr Trp Leu Pro His Ile Gln Leu Cys Val 
305                 310                 315                 320 

Cys Tyr Ser Arg Leu Gly Gln Tyr Arg Lys Ala Tyr Asp His Asn Glu 
                325                 330                 335     

Arg Ala Ala Glu Tyr Leu Gly Glu Asp Pro Met Ile Val His Asn Arg 
            340                 345                 350         

Ser Val Leu Arg Ala Trp Met Asp Gly Glu Leu Glu Lys Pro 
        355                 360                 365     

<210>   182
<211>   366
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 171

<400>   182
Met Ser Ala Lys Thr Glu Asn Thr Trp Ser Leu Cys Met Ile Val Lys 
                5                   10                  15      

Asp Glu Glu Ala Val Leu Asp Arg Cys Leu Gln Ser Ile Ala Asp Ile 
            20                  25                  30          

Val Asp Glu Ile Val Ile Val Asp Thr Gly Ser Gln Asp Arg Thr Gln 
        35                  40                  45              

Glu Ile Ala Arg Lys Tyr Thr Asp Leu Val Phe Asp Phe Glu Trp Val 
    50                  55                  60                  

Asp Asp Phe Ser Glu Ala Arg Asn Glu Ser Phe Arg His Ala Ser Met 
65                  70                  75                  80  

Asp Tyr Val Leu Trp Leu Asp Ala Asp Asp Val Val Ser Asp Val Asp 
                85                  90                  95      

Arg Ile Lys Leu Ala Glu Phe Lys Lys Asn Leu Ser Ser Asp Val Asp 
            100                 105                 110         

Ala Val Thr Met Trp Tyr His Leu Ala Phe Gln Gly Asp Gln Pro Thr 
        115                 120                 125             

Val Ser Ser Arg Leu Val Arg Leu Val Lys Arg Ser Arg Gly Phe Val 
    130                 135                 140                 

Trp Arg Gly Arg Val His Glu Tyr Leu Glu Ile Asn Gly Asn Ile Leu 
145                 150                 155                 160 

Asn Ser Asp Ile Ala Ile Ile His Arg Pro Val Glu His Asp Ala Ala 
                165                 170                 175     

Arg Asn Leu Arg Ile Tyr Glu Lys Lys Leu Ala Leu Gly Glu Asp Phe 
            180                 185                 190         

Ser Pro Arg Asp Met Leu Tyr Tyr Ala Asn Glu Leu Leu Asp His Ala 
        195                 200                 205             

Gln Tyr Glu Lys Ala Val Gln Trp Tyr Lys Arg Phe Leu Ala Thr Gly 
    210                 215                 220                 

Gln Cys Trp Lys Glu Asp Ala Ile Thr Ala Cys Phe Lys Leu Ala Glu 
225                 230                 235                 240 

Cys Phe Arg Ala Met Asn Gln Pro Asp Gln Ser Lys Gln Ala Val Leu 
                245                 250                 255     

His Ser Phe Leu Tyr Asp Thr Pro Arg Ala Glu Ala Cys Cys Arg Ile 
            260                 265                 270         

Gly Tyr Gly Tyr Leu Glu Glu Gly Lys Ile Asp Gln Ala Ile Phe Trp 
        275                 280                 285             

Tyr Asp Leu Ala Thr Lys Cys Arg Arg Pro Ala Asn Phe Val Gly Phe 
    290                 295                 300                 

Val Asn His Ala Cys Glu Thr Trp Leu Pro His Ile Gln Leu Cys Val 
305                 310                 315                 320 

Cys Tyr Ser Arg Leu Gly Gln Tyr Arg Lys Ala Tyr Asp His Asn Glu 
                325                 330                 335     

Arg Ala Ala Glu Tyr Leu Gly Glu Asp Pro Met Ile Val His Asn Arg 
            340                 345                 350         

Ser Val Leu Arg Ala Trp Met Asp Gly Glu Leu Glu Lys Pro 
        355                 360                 365     

<210>   183
<211>   1101
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 172

<400>   183
gtgtccgcta aaacggaaaa tacttggagc ttatgtatga tcgtgaaaga tgaggaggct       60

gtactggatc gctgtctcca atcgattgcc gacattgtcg atgaaatcgt gatagttgat      120

acaggttcgc aagacaggac ccaagagatc gctcgcaaat acacagatct ggtgttcgat      180

tttgagtggg tggatgattt cagcgaggcg cgcaacgaat cgttccggca cgccagtatg      240

gattacgtcc tctggctaga cgccgacgac gttgtgtcag atgtagatcg aatcaaactg      300

gcagaattca agaaaaacct ttcttccgac gtggacgcag tgacaatgtg gtatcacctc      360

gcatttcaag gtgatcagcc gaccgtcagt tctcgtctcg ttcgcctcgt gaaacgatcg      420

cgcggttttg tttggcgggg ccgcgtccat gaatatcttg aaattaacgg caacatcctc      480

aacagcgaca tcgcaatcat ccatcgccct gtcgagcatg atgccgctcg caatcttcgc      540

atctacgaga agaagctcgc gcttggcgaa gatttcagcc cacgcgacat gctctactac      600

gccaatgagc tgctggatca tgcacaatac gagaaggctg tacaatggta caagcggttt      660

ttagcaacag gacaatgttg gaaagaggac gccatcacag cttgcttcaa gctcgccgaa      720

tgctttcgtg cgatgaatca accggagcaa agtaagcaag ctgtgttaca ctcgttcctg      780

tacgatacgc cgcgagccga agcgtgttgt cgtatcgggt atggttactt ggaagaggga      840

aagatcgatc aggccatctt ttggtatgat ctagcaacca aatgcaggcg tccagccaat      900

tttgtgggat ttgtcaacca tgcatgtgaa acctggttac cccatattca actttgtgtg      960

tgttatagcc ggctcggcaa ttacaggaaa gcttatgatc ataacgaacg agccgcggag     1020

tacctaggtg aagatccgat gatcgtccac aatcgttctg tattgcgagc ctggatggat     1080

ggcgaactcg agaaaccgta a                                               1101


<210>   184
<211>   1101
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 172

<400>   184
gtgtccgcta aaacggaaaa tacttggagc ttatgtatga tcgtgaaaga tgaggaggct       60

gtactggatc gctgtctcca atcgattgcc gacattgtcg atgaaatcgt gatagttgat      120

acaggttcgc aagacaggac ccaagagatc gctcgcaaat acacagatct ggtgttcgat      180

tttgagtggg tggatgattt cagcgaggcg cgcaacgaat cgttccggca cgccagtatg      240

gattacgtcc tctggctaga cgccgacgac gttgtgtcag atgtagatcg aatcaaactg      300

gcagaattca agaaaaacct ttcttccgac gtggacgcag tgacaatgtg gtatcacctc      360

gcatttcaag gtgatcagcc gaccgtcagt tctcgtattg ttcgcctcgt gaaacgatcg      420

cgcggttttg tttggcgggg ccgcgtccat gaatatcttg aaattaacgg caacatcctc      480

aacagcgaca tcgcaatcat ccatcgccct gtcgagcatg atgccgctcg caatcttcgc      540

atctacgaga agaagctcgc gcttggcgaa gatttcagcc cacgcgacat gctctactac      600

gccaatgagc tgctggatca tgcacaatac gagaaggctg tacaatggta caagcggttt      660

ttagcaacag gacaatgttg gaaagaggac gccatcacag cttgcttcaa gctcgccgaa      720

tgctttcgtg cgatgaatca accggagcaa agtaagcaag ctgtgttaca ctcgttcctg      780

tacgatacgc cgcgagccga agcgtgttgt cgtatcgggt atggttactt ggaagaggga      840

aagatcgatc aggccatctt ttggtatgat ctagcaacca aatgcaggcg tccagccaat      900

tttgtgggat ttgtcaacca tgcatgtgaa acctggttac cccatattca actttgtgtg      960

tgttatagcc ggctcggcca atacaggaaa gcttatgatc ataacgaacg agccgcggag     1020

tacctaggtg aagatccgat gatcgtccac aatcgttctg tattgcgagc ctggatggat     1080

ggcgaactcg agaaaccgta a                                               1101


<210>   185
<211>   1101
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 172

<400>   185
gtgtccgcta aaacggaaaa tacttggagc ttatgtatga tcgtgaaaga tgaggaggct       60

gtactggatc gctgtctcca atcgattgcc gacattgtcg atgaaatcgt gatagttgat      120

acaggttcgc aagacaggac ccaagagatc gctcgcaaat acacagatct ggtgttcgat      180

tttgagtggg tggatgattt cagcgaggcg cgcaacgaat cgttccggca cgccagtatg      240

gattacgtcc tctggctaga cgccgacgac gttgtgtcag atgtagatcg aatcaaactg      300

gcagaattca agaaaaacct ttcttccgac gtggacgcag tgacaatgtg gtatcacctc      360

gcatttcaag gtgataatcc gaccgtcagt tctcgtctcg ttcgcctcgt gaaacgatcg      420

cgcggttttg tttggcgggg ccgcgtccat gaatatcttg aaattaacgg caacatcctc      480

aacagcgaca tcgcaatcat ccatcgccct gtcgagcatg atgccgctcg caatcttcgc      540

atctacgaga agaagctcgc gcttggcgaa gatttcagcc cacgcgacat gctctactac      600

gccaatgagc tgctggatca tgcacaatac gagaaggctg tacaatggta caagcggttt      660

ttagcaacag gacaatgttg gaaagaggac gccatcacag cttgcttcaa gctcgccgaa      720

tgctttcgtg cgatgaatca accggagcaa agtaagcaag ctgtgttaca ctcgttcctg      780

tacgatacgc cgcgagccga agcgtgttgt cgtatcgggt atggttactt ggaagaggga      840

aagatcgatc aggccatctt ttggtatgat ctagcaacca aatgcaggcg tccagccaat      900

tttgtgggat ttgtcaacca tgcatgtgaa acctggttac cccatattca actttgtgtg      960

tgttatagcc ggctcggcca atacaggaaa gcttatgatc ataacgaacg agccgcggag     1020

tacctaggtg aagatccgat gatcgtccac aatcgttctg tattgcgagc ctggatggat     1080

ggcgaactcg agaaaccgta a                                               1101


<210>   186
<211>   1101
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 172

<400>   186
gtgtccgcta aaacggaaaa tacttggagc ttatgtatga tcgtgaaaga tgaggaggct       60

gtactggatc gctgtctcca atcgattgcc gacattgtcg atgaaatcgt gatagttgat      120

acaggttcgc aagacaggac ccaagagatc gctcgcaaat acacagatct ggtgttcgat      180

tttgagtggg tggatgattt cagcgaggcg cgcaacgaat cgttccggca cgccagtatg      240

gattacgtcc tctggctaga cgccgacgac gttgtgtcag atgtagatcg aatcaaactg      300

gcagaattca agaaaaacct ttcttccgaa gtggacgcag tgacaatgtg gtatcacctc      360

gcatttcaag gtgatcagcc gaccgtcagt tctcgtctcg ttcgcctcgt gaaacgatcg      420

cgcggttttg tttggcgggg ccgcgtccat gaatatcttg aaattaacgg caacatcctc      480

aacagcgaca tcgcaatcat ccatcgccct gtcgagcatg atgccgctcg caatcttcgc      540

atctacgaga agaagctcgc gcttggcgaa gatttcagcc cacgcgacat gctctactac      600

gccaatgagc tgctggatca tgcacaatac gagaaggctg tacaatggta caagcggttt      660

ttagcaacag gacaatgttg gaaagaggac gccatcacag cttgcttcaa gctcgccgaa      720

tgctttcgtg cgatgaatca accggagcaa agtaagcaag ctgtgttaca ctcgttcctg      780

tacgatacgc cgcgagccga agcgtgttgt cgtatcgggt atggttactt ggaagaggga      840

aagatcgatc aggccatctt ttggtatgat ctagcaacca aatgcaggcg tccagccaat      900

tttgtgggat ttgtcaacca tgcatgtgaa acctggttac cccatattca actttgtgtg      960

tgttatagcc ggctcggcca atacaggaaa gcttatgatc ataacgaacg agccgcggag     1020

tacctaggtg aagatccgat gatcgtccac aatcgttctg tattgcgagc ctggatggat     1080

ggcgaactcg agaaaccgta a                                               1101


<210>   187
<211>   1101
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 172

<400>   187
gtgtccgcta aaacggaaaa tacttggagc ttatgtatga tcgtgaaaga tgaggaggct       60

gtactggatc gctgtctcca atcgattgcc gacattgtcg atgaaatcgt gatagttgat      120

acaggttcgc aagacaggac ccaagagatc gctcgcaaat acacagatct ggtgttcgat      180

tttgagtggg tggatgattt cagcgaggcg cgcaacgaat cgttccggca cgccagtatg      240

gattacgtcc tctggctaga cgccgacgac gttgtgtcag atgtagatcg aatcaaactg      300

gcagaattca agaaaaacct ttcttccgac gtggacgcag tgacaatgtg gtatcacctc      360

gcatttcaag gtgatcagcc gaccgtcagt tctcgtctcg ttcgcctcgt gaaacgatcg      420

cgcggttttg tttggcgggg ccgcgtccat gaatatcttg aaattaacgg caacatcctc      480

aacagcgaca tcgcaatcat ccatcgccct gtcgagcatg atgccgctcg caatcttcgc      540

atctacgaga agaagctcgc gcttggcgaa gatttcagcc cacgcgacat gctctactac      600

gccaatgagc tgctggatca tgcacaatac gagaaggctg tacaatggta caagcggttt      660

ttagcaacag gacaatgttg gaaagaggac gccatcacag cttgcttcaa gctcgccgaa      720

tgctttcgtg cgatgaatca accggatcaa agtaagcaag ctgtgttaca ctcgttcctg      780

tacgatacgc cgcgagccga agcgtgttgt cgtatcgggt atggttactt ggaagaggga      840

aagatcgatc aggccatctt ttggtatgat ctagcaacca aatgcaggcg tccagccaat      900

tttgtgggat ttgtcaacca tgcatgtgaa acctggttac cccatattca actttgtgtg      960

tgttatagcc ggctcggcca atacaggaaa gcttatgatc ataacgaacg agccgcggag     1020

tacctaggtg aagatccgat gatcgtccac aatcgttctg tattgcgagc ctggatggat     1080

ggcgaactcg agaaaccgta a                                               1101


<210>   188
<211>   397
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   188
Met Thr Leu Glu Ile Gly Tyr Val Ser Thr Tyr Val Pro Arg Lys Cys 
                5                   10                  15      

Gly Leu Ala Thr Tyr Thr His His Leu Arg Gln Ser Val Arg Arg Ala 
            20                  25                  30          

Ala Gly Pro Ser Ala Ala Asp Gln Val Ile Ala Met Leu Ala Pro Asp 
        35                  40                  45              

Glu Asp Val Lys Asn Tyr Asn Arg Ser Tyr Trp Phe Leu Arg Arg Asp 
    50                  55                  60                  

Glu Arg Arg Asp Tyr Ala Arg Ile Ala Arg Arg Val Asn Asp Ser Arg 
65                  70                  75                  80  

Ile Gly Val Val Ser Leu Gln His Glu Phe Gly Ile Phe Gly Gly Glu 
                85                  90                  95      

Ala Gly Ser Tyr Ile Leu Asp Phe Ile Asp Ala Leu Asp Lys Pro Leu 
            100                 105                 110         

Val Thr Thr Phe His Thr Val Phe Gln Lys Pro Met Ser Pro Tyr Arg 
        115                 120                 125             

Glu Val Gln Lys Glu Ile Ala Glu Arg Ser Asp Arg Ile Val Val Met 
    130                 135                 140                 

Asn Arg Gln Ala Ile Asp Tyr Leu Val Asp Ala Phe Gly Ile Ser Pro 
145                 150                 155                 160 

Ser Lys Ile His Tyr Leu Pro His Gly Thr Pro Val Arg Ser Val Thr 
                165                 170                 175     

Pro Arg Ala Glu Leu Arg Lys Gln Phe Gly Trp Gln Asp Arg Ala Val 
            180                 185                 190         

Ile Val Thr Phe Gly Leu Leu Gly Pro Ser Lys Gly Ile Glu Phe Met 
        195                 200                 205             

Leu Asp Ala Met Pro Asp Ile Val Arg Glu Val Pro Asn Ala Leu Tyr 
    210                 215                 220                 

Val Ile Ala Gly Gln Thr His Pro Glu Ile Val Lys Arg Glu Gly Glu 
225                 230                 235                 240 

Ala Tyr Arg Glu Ser Leu Met Arg Arg Ile His Glu Leu His Leu Asp 
                245                 250                 255     

Asp His Val Val Met Leu Asn Gln Tyr Met Ser Glu Ser Asp Ile Val 
            260                 265                 270         

Asp Leu Ile Thr Ala Ala Asp Leu Tyr Val Thr Pro Tyr Pro Asn Met 
        275                 280                 285             

Glu Gln Ile Thr Ser Gly Thr Leu Ala Tyr Ala Val Gly Met Gly Gln 
    290                 295                 300                 

Val Val Leu Thr Thr Pro Tyr Ala Tyr Ala Arg Asp Leu Leu Lys Asp 
305                 310                 315                 320 

Val Pro Glu Leu Leu Val Pro Tyr Gly Asp Thr Arg Ala Trp Ala Asp 
                325                 330                 335     

Arg Ala Val Glu Ile Leu Thr Asn Arg Asp Val Arg Ala Lys Tyr Ala 
            340                 345                 350         

Glu Arg Ile Ser Ala Ile Gly Ala Asp Met Thr Trp Pro Arg Val Gly 
        355                 360                 365             

Glu Arg His Trp Gln Leu Phe Gln Asp Val Ala Leu Arg Ala Arg His 
    370                 375                 380                 

Arg Ala Ser Gly Val Lys Gly Phe Ala Val Ile Ala His 
385                 390                 395         

<210>   189
<211>   1194
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   189
atgacgttgg aaatcggata tgtcagcact tatgtccccc ggaaatgcgg acttgccaca       60

tatacacacc atttgcgcca gagcgttcgc cgggcggcgg gaccgtccgc ggccgaccag      120

gtcatcgcca tgttggcccc ggatgaggac gtgaagaact acaaccgctc gtactggttc      180

cttcgccggg atgagcgcag ggattacgcg cgcattgcac ggcgggtgaa cgacagccga      240

attggcgtgg tctccctgca gcacgaattc ggcatctttg gcggcgaagc agggtcgtac      300

atcctcgact tcattgacgc gctggacaaa ccgctcgtga cgacgtttca caccgtcttt      360

caaaagccca tgtcgcctta tcgcgaagtg cagaaggaga tcgccgagag aagcgaccgc      420

atcgtcgtga tgaatcgaca ggccatcgat tatctcgtcg acgcattcgg catctcgccg      480

tcgaagatcc actatctccc gcacggcacg ccggtgcgat ctgtgacgcc gcgggccgag      540

ttgcggaagc agttcggttg gcaagaccgg gccgtgatcg tcacctttgg gctgctcggt      600

ccgagcaagg gcattgagtt catgttggat gcgatgccgg acatcgtgcg cgaggttccg      660

aacgcgctgt acgtgatcgc cggacagacg cacccggaaa ttgtcaagcg cgagggcgag      720

gcgtaccgcg agtcgctcat gcggcgaatc catgagctcc acttggacga tcacgtcgtg      780

atgctgaacc agtacatgtc cgagtccgac atcgtggatc ttatcacggc ggcggatctc      840

tacgtcacgc cttatccgaa catggagcag attacgagcg ggacgctggc ctacgcggtc      900

ggcatggggc aggtcgtgct gacgacgccg tacgcgtacg cgcgcgacct tctgaaggac      960

gtgccggaac tgctcgtgcc ctacggggac acgcgcgcgt gggcggatcg ggctgtggaa     1020

atcctgacga accgcgatgt gcgcgcgaag tacgcggagc ggatttcggc gattggggca     1080

gacatgacgt ggccgcgcgt gggcgagcgc cattggcagt tgttccagga cgtcgccctg     1140

cgggctcgcc atcgcgcatc gggggtgaag ggatttgcgg tcatcgcaca ctga           1194


<210>   190
<211>   394
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   190
Ile Arg Ile Ala Tyr Val Ser Thr Tyr Pro Pro Arg Arg Cys Gly Leu 
                5                   10                  15      

Ala Thr Phe Thr Glu His Leu Arg Gln Ser Ile Asp Gly Val Arg Gly 
            20                  25                  30          

Pro Ser Asp Gly Asp Arg Val Ile Val Leu Tyr Asn Glu Ser Asp Gly 
        35                  40                  45              

Asp Asp Ala Tyr Arg His Asn Pro Ala Tyr Trp Pro Leu Pro Ala Gln 
    50                  55                  60                  

Asn Arg Ala Ala Tyr Ala Glu Met Ala Lys Arg Val Asn Glu Ser Asp 
65                  70                  75                  80  

Ile Asp Val Val Leu Leu Gln His Glu Phe Gly Ile Phe Gly Gly Glu 
                85                  90                  95      

Ala Gly Glu Tyr Ile Leu Asp Phe Ile Ala Ala Leu Asn Lys Pro Leu 
            100                 105                 110         

Val Thr Thr Phe His Thr Val Phe Ala Asp Pro Pro Leu Pro Tyr Arg 
        115                 120                 125             

Pro Ile Gln Glu Lys Ile Ala Ala Ala Ser Asp Ala Ile Ile Val Met 
    130                 135                 140                 

Asn Arg Gln Ala Ile Pro Tyr Leu Val Lys Ala Phe Gly Leu Pro Glu 
145                 150                 155                 160 

Glu Lys Ile Val Tyr Ile Pro His Gly Ala Pro Gly Pro Ser Ser Glu 
                165                 170                 175     

Asn Arg Asp Ser Leu Arg Arg Arg Leu Gly Phe Ser Gly Arg Lys Val 
            180                 185                 190         

Met Leu Thr Phe Gly Leu Leu Ser Arg Gly Lys Gly Ile Glu Ser Val 
        195                 200                 205             

Leu Ala Ala Leu Pro Gly Val Val Arg Lys Val Pro Glu Ala Leu Tyr 
    210                 215                 220                 

Val Ile Ala Gly Gln Thr His Pro Glu Val Lys Lys Arg Glu Gly Glu 
225                 230                 235                 240 

Ala Tyr Arg Glu Glu Leu Lys Ser Leu Ile His Arg Leu Gly Leu Glu 
                245                 250                 255     

Leu His Val Tyr Met Glu Asp Arg Tyr Phe Ser Glu Glu Glu Leu Ile 
            260                 265                 270         

Asp Tyr Leu Thr Ala Cys Asp Leu Tyr Val Thr Pro Tyr Pro Gly Met 
        275                 280                 285             

Gln Gln Ile Thr Ser Gly Thr Leu Ala Tyr Ala Val Gly Val Gly Arg 
    290                 295                 300                 

Pro Val Val Ser Thr Pro Tyr Glu His Ala Arg Asp Leu Leu Gln Gly 
305                 310                 315                 320 

Cys Glu Glu Leu Leu Leu Pro Tyr Gly Asp Thr Thr Ala Trp Glu Glu 
                325                 330                 335     

Arg Leu Gly Gln Leu Leu Ala Asp Glu Ala Ala Leu Lys Arg Trp Glu 
            340                 345                 350         

Glu Lys Val Arg Gln Ile Gly Ala Asn Thr His Trp Pro Arg Val Gly 
        355                 360                 365             

Glu Gln His Val Ala Leu Phe Ala Arg Met Cys Asp Ala Lys Arg Gly 
    370                 375                 380                 

Glu Val Lys Thr Ile Gly Thr Val Ser His 
385                 390                 

<210>   191
<211>   393
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   191
Ile Ala Tyr Val Ser Thr Tyr Pro Pro Arg Arg Cys Gly Leu Ala Thr 
                5                   10                  15      

Phe Thr Glu His Leu Arg Gln Ser Ile Asp Ser Val Arg Gly Lys Val 
            20                  25                  30          

Glu Gly Asp Arg Val Ile Val Leu Tyr Asn Glu Ile Asp Gly Asp Asp 
        35                  40                  45              

Ala Tyr Arg Gly Asn Pro Ala Tyr Trp Pro Leu Pro Ala Gln Asn Arg 
    50                  55                  60                  

Ala Ala Tyr Glu Lys Met Ala Arg Arg Val Asn Glu Ser Asp Ile Asp 
65                  70                  75                  80  

Val Val Val Leu Gln His Glu Phe Gly Ile Phe Gly Gly Glu Ala Gly 
                85                  90                  95      

Glu Tyr Ile Leu Asp Phe Ile Ala Ala Leu Gln Lys Pro Leu Ile Thr 
            100                 105                 110         

Thr Phe His Thr Val Phe Ala Ala Pro Glu Pro Pro Tyr Arg Pro Ile 
        115                 120                 125             

Gln Glu Lys Ile Ala Ala Ala Ser Asp Ala Ile Ile Val Met Asn Arg 
    130                 135                 140                 

Gln Ala Ile Gly Tyr Leu Val Lys Ala Phe Gly Leu Pro Glu Glu Lys 
145                 150                 155                 160 

Ile Val Tyr Ile Pro His Gly Ala Pro Gly Pro Ser Ser Glu Glu Arg 
                165                 170                 175     

Gln Ser Leu Arg Ser Arg Leu Gly Phe His Gly Arg Lys Val Met Phe 
            180                 185                 190         

Thr Phe Gly Leu Leu Ser Arg Gly Lys Gly Ile Glu Ser Val Leu Thr 
        195                 200                 205             

Ala Leu Pro Gly Val Val Arg Lys Val Pro Glu Thr Leu Tyr Val Ile 
    210                 215                 220                 

Ala Gly Gln Thr His Pro Glu Val Lys Lys Arg Glu Gly Glu Ala Tyr 
225                 230                 235                 240 

Arg Glu Glu Leu Lys Ala Leu Ile His Arg Leu Gly Leu Asp Asp His 
                245                 250                 255     

Val Arg Met Glu Asp Arg Tyr Phe Ser Glu Glu Glu Leu Ile Asp Tyr 
            260                 265                 270         

Leu Thr Ala Cys Asp Leu Tyr Val Thr Pro Tyr Pro Gly Met Gln Gln 
        275                 280                 285             

Ile Thr Ser Gly Thr Leu Ala Tyr Ala Val Gly Val Gly Arg Pro Val 
    290                 295                 300                 

Val Ser Thr Pro Tyr Glu His Ala Arg Asp Leu Leu Gln Gly Cys Glu 
305                 310                 315                 320 

Glu Leu Leu Leu Pro Tyr Gly Asn Thr Ser Val Trp Glu Glu Arg Leu 
                325                 330                 335     

Val Gln Leu Leu Ala Asp Glu Ala Ala Leu Glu Arg Trp Glu Arg Ile 
            340                 345                 350         

Val Arg Gln Ile Gly Ala Asn Thr His Trp Pro Arg Val Gly Glu Gln 
        355                 360                 365             

His Ile Ala Leu Phe Glu Arg Val Cys Thr Ala Ala Asn Ser Gly Glu 
    370                 375                 380                 

Val Lys Ala Val Asp Phe Val Ser His 
385                 390             

<210>   192
<211>   387
<212>   PRT
<213>   Rhodopirellula baltica SH 1

<400>   192
Leu Lys Ile Ala Phe Val Gly Asp Tyr Leu Pro Arg Lys Cys Gly Ile 
                5                   10                  15      

Ala Thr Phe Thr His Asp Leu Arg Ile Gly Val Ala Arg Glu Thr Cys 
            20                  25                  30          

Ala Glu Cys Ile Val Val Thr Leu Asp Asp Ile Glu Gly Gly Tyr Ala 
        35                  40                  45              

Tyr Asp Asn Glu Val Gln Phe Gln Val Ala Asp Gln Glu Leu Asp Glu 
    50                  55                  60                  

Tyr Gln Ser Ala Ala Asp Phe Leu Asn Phe Ser Asn Val Asp Val Ile 
65                  70                  75                  80  

Ser Leu Gln His Glu Phe Gly Ile Phe Gly Gly Pro Cys Gly Ser His 
                85                  90                  95      

Ile Leu Ala Leu Leu Gln Asp Val Arg Met Pro Val Val Thr Thr Leu 
            100                 105                 110         

His Thr Val Leu Ser Glu Pro Asn Glu Ala Gln Arg Ala Val Met Met 
        115                 120                 125             

Gln Leu Ile Arg Leu Ser Thr Arg Leu Val Val Met Thr Glu Arg Ser 
    130                 135                 140                 

Arg Gln Thr Leu Leu Asp Thr Tyr Ser Val Asp Ser Asp Gln Ile Asp 
145                 150                 155                 160 

Val Ile Ala His Gly Ile Pro Glu Ala Pro Glu Thr Asp Gln Ser Val 
                165                 170                 175     

Leu Lys Glu Gln Phe Gly Val Glu Asp Lys Pro Val Ala Leu Thr Phe 
            180                 185                 190         

Gly Leu Leu Ser Pro Gly Lys Gly Ile Glu His Val Leu Lys Ala Ile 
        195                 200                 205             

Pro Glu Ile Val Ala Lys Phe Pro Asp Phe Ile Tyr Ile Ile Leu Gly 
    210                 215                 220                 

Ala Thr His Pro Ser Leu Leu Arg Glu Gln Gly Glu Arg Tyr Arg Ile 
225                 230                 235                 240 

Ser Leu Glu Arg Met Ala Lys Glu Leu Gly Val Ser Lys His Val Ser 
                245                 250                 255     

Phe Tyr Asn Arg Phe Val Glu Leu Glu Glu Leu Thr Glu Phe Ile Gly 
            260                 265                 270         

Ala Ala Asp Leu Tyr Ile Thr Pro Tyr Leu Asn Val Glu Gln Ala Val 
        275                 280                 285             

Ser Gly Thr Leu Ala Tyr Ala Phe Gly Cys Gly Gln Ala Val Ile Ser 
    290                 295                 300                 

Thr Pro Tyr Trp His Ala Glu Glu Leu Leu Ala Asp Gly Arg Gly Val 
305                 310                 315                 320 

Leu Val Pro Phe Ala Asp Pro Ser Ala Ile Ala Arg Glu Val Ile Gly 
                325                 330                 335     

Leu Leu Ser Asp Asp Asp Arg Arg Leu Ala Met Arg Asp Lys Ala Tyr 
            340                 345                 350         

Asp Leu Gly Arg Asp Met Thr Trp Glu His Val Ser Gln Leu Tyr Ile 
        355                 360                 365             

Asp Ser Phe Asn Arg Ala Arg Asp Gln Arg Thr Ser Ser Leu Lys Pro 
    370                 375                 380                 

Leu Ala Val 
385         

<210>   193
<211>   386
<212>   PRT
<213>   Rhodospirillum rubrum ATCC 11170

<400>   193
Ile Ala Phe Ile Gly Asn Ser Leu Pro Arg Arg Cys Gly Ile Ala Thr 
                5                   10                  15      

Phe Thr Thr His Leu Arg Gln Ala Val Gly Thr Arg Phe Ala Asp Ile 
            20                  25                  30          

Glu Thr Phe Ile Val Ala Met Thr Asp Pro Gly Gln Asp Tyr Ala Tyr 
        35                  40                  45              

Pro Ala Ser Val Pro Ile Glu Val His Gln Asp Arg Leu Glu Asp Tyr 
    50                  55                  60                  

Leu His Ala Ala Asp Leu Leu Asn Asp Gly Asn Val Asp Ile Ala Cys 
65                  70                  75                  80  

Leu Gln His Glu Phe Gly Ile Phe Gly Gly Glu Ala Gly Glu Asn Ile 
                85                  90                  95      

Leu Ala Leu Leu Gly Arg Leu Thr Met Pro Ile Val Thr Thr Leu His 
            100                 105                 110         

Thr Val Leu Asp Gln Pro Thr Pro Ala Gln Arg Asp Val Leu Asp Arg 
        115                 120                 125             

Leu Phe Ala Leu Ser Ala Lys Leu Ile Val Met Ala Gln Lys Ala Arg 
    130                 135                 140                 

Glu Leu Leu Arg Thr Val Tyr Arg Val Pro Ala Asp Lys Ile Glu Val 
145                 150                 155                 160 

Ile Ala His Gly Ile Pro Asp Phe Pro Phe Val Gly Ser Glu Lys Ala 
                165                 170                 175     

Lys Ala Glu Leu Gly Phe Ser Gly Arg Ala Val Ile Leu Thr Phe Gly 
            180                 185                 190         

Leu Leu Ser Pro Asn Lys Gly Ile Glu Val Met Ile Asp Ala Met Pro 
        195                 200                 205             

Ala Ile Val Lys Ser Arg Pro Asp Ala Val Tyr Val Val Leu Gly Ala 
    210                 215                 220                 

Thr His Pro Asn Leu Val Arg Glu Gln Gly Glu Ala Tyr Arg Asp Ser 
225                 230                 235                 240 

Leu Arg Ala Arg Val Gln Asp Leu Gly Leu Gln Asp His Val Val Phe 
                245                 250                 255     

Leu Asp Arg Phe Val Asp Gln Asp Thr Leu Leu Arg Phe Ile Ser Met 
            260                 265                 270         

Cys Asp Ile Tyr Ala Thr Pro Tyr Leu Asn Leu Ala Gln Met Thr Ser 
        275                 280                 285             

Gly Thr Leu Ala Tyr Ser Phe Gly Leu Gly Lys Pro Val Val Ser Thr 
    290                 295                 300                 

Pro Tyr Trp His Ala Arg Glu Leu Leu Ala Asp Gly Arg Gly Ile Leu 
305                 310                 315                 320 

Val Pro Phe Gly Asp Ala Gly Ala Ile Gly Leu Ala Ile Ala Gly Leu 
                325                 330                 335     

Leu Thr Asp Asp Ala Arg Arg Glu Ala Met Ala Glu Arg Ala Tyr Ile 
            340                 345                 350         

Gly Ser Arg Ser Met Ile Trp Gln Arg Ser Ala Glu Arg Tyr Leu Asp 
        355                 360                 365             

Val Phe Thr Ala Val Leu Gln Asp Arg Gln Val His Glu Ala Ala Pro 
    370                 375                 380                 

Val Glu 
385     

<210>   194
<211>   375
<212>   PRT
<213>   Pedobacter sp. BAL39

<400>   194
Met Lys Ile Ala Tyr Ile Ser Ser Tyr Pro Pro Arg Glu Cys Gly Ile 
                5                   10                  15      

Ala Thr Phe Asn His Asn Leu Met Arg Ala Ile Gly His Asp Lys Ser 
            20                  25                  30          

Ala Val Ser Glu Asp Ser Phe Val Val Ala Met Asn Asp Ser Asp Ser 
        35                  40                  45              

Ile Thr Thr Tyr Glu Tyr Pro Lys Glu Val Lys Tyr Ile Ile Arg Gln 
    50                  55                  60                  

Glu Asn Gln Lys Asp Tyr Ile Arg Ala Ala Asp Tyr Ile Asn Thr Ser 
65                  70                  75                  80  

Leu Ala Asp Ala Cys Ile Leu Glu His Glu Phe Gly Ile Phe Gly Gly 
                85                  90                  95      

Glu Ser Gly Val Tyr Ile Leu Pro Leu Leu Ala Arg Leu Lys Lys Pro 
            100                 105                 110         

Leu Ile Thr Ile Phe His Thr Ile Leu Lys Asp Pro Ser Tyr Met Gln 
        115                 120                 125             

Leu Thr Ile Ile Arg Glu Ile Ala Lys Tyr Ser Ser Arg Ile Val Val 
    130                 135                 140                 

Met Ser His Arg Ala Val Gly Phe Leu Thr Gly Ile Tyr Gly Ile Pro 
145                 150                 155                 160 

Phe Ala Lys Ile Gln Leu Ile Glu His Gly Val Pro Asp Leu Glu Ala 
                165                 170                 175     

Lys Thr Asp Asn Pro Val Arg Gln Ser Leu Ala Phe Lys Gly Lys Lys 
            180                 185                 190         

Val Leu Phe Thr Phe Gly Leu Ile Ser Arg Asn Lys Gly Leu Glu Thr 
        195                 200                 205             

Val Ile Glu Ala Leu Pro Glu Ile Val Ala Gln His Pro Asp Val Met 
    210                 215                 220                 

Tyr Val Ile Leu Gly Thr Thr His Pro Gly Val Val Arg Asn Ser Gly 
225                 230                 235                 240 

Glu Glu Tyr Arg Asp Ser Leu Lys Arg Leu Ala Gln Lys Leu Asn Val 
                245                 250                 255     

Glu Glu Asn Leu Thr Phe Ile Asn Lys Phe Val Ser Glu Gly Glu Leu 
            260                 265                 270         

Phe Asp Tyr Leu Thr Ala Cys Asp Met Tyr Ile Thr Pro Tyr Leu Asn 
        275                 280                 285             

Glu Ala Gln Ile Thr Ser Gly Thr Leu Ser Tyr Ala Val Gly Ala Gly 
    290                 295                 300                 

Ala Ala Val Val Ser Thr Pro Tyr Trp His Ala Gln Glu Leu Leu Ala 
305                 310                 315                 320 

Asp Asn Arg Gly Arg Leu Phe Asp Phe Lys Asp Ser His Ala Leu Ala 
                325                 330                 335     

Asn Asn Val Asn Glu Leu Leu Ser Asp Lys Gln Lys Leu Ser Glu Leu 
            340                 345                 350         

Lys Gly Asn Ala Tyr Glu Tyr Gly Leu His Leu Arg Trp Pro Ser Thr 
        355                 360                 365             

Gly Gln Val Phe Val Asp Val 
    370                 375 

<210>   195
<211>   397
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 188

<400>   195
Met Thr Leu Glu Ile Gly Tyr Val Ser Thr Tyr Val Pro Arg Lys Cys 
                5                   10                  15      

Gly Leu Ala Thr Tyr Thr His His Leu Arg Gln Ser Val Arg Arg Ala 
            20                  25                  30          

Ala Gly Pro Ser Ala Ala Asp Gln Val Ile Ala Met Leu Ala Pro Asp 
        35                  40                  45              

Glu Asp Val Lys Asn Tyr Asn Arg Ser Tyr Trp Phe Leu Arg Arg Asp 
    50                  55                  60                  

Glu Arg Arg Asp Tyr Ala Arg Ile Ala Arg Arg Val Asn Asp Ser Arg 
65                  70                  75                  80  

Ile Gly Val Val Ser Leu Gln His Glu Phe Gly Ile Phe Gly Gly Glu 
                85                  90                  95      

Ala Gly Ser Tyr Ile Leu Asp Phe Ile Asp Ala Leu Asp Lys Pro Leu 
            100                 105                 110         

Val Thr Thr Phe His Thr Val Phe Gln Lys Pro Met Ser Pro Tyr Arg 
        115                 120                 125             

Glu Val Gln Lys Glu Ile Ala Glu Arg Ser Asp Arg Ile Val Val Met 
    130                 135                 140                 

Asn Arg Gln Ala Ile Asp Tyr Leu Val Asp Ala Phe Gly Ile Ser Pro 
145                 150                 155                 160 

Ser Lys Ile His Tyr Leu Pro His Gly Thr Pro Val Arg Ser Val Thr 
                165                 170                 175     

Pro Arg Ala Glu Leu Arg Lys Gln Phe Gly Trp Gln Asp Arg Ala Val 
            180                 185                 190         

Ile Val Thr Phe Gly Leu Leu Gly Pro Ser Lys Gly Ile Glu Phe Met 
        195                 200                 205             

Leu Asp Ala Met Pro Asp Ile Val Arg Glu Val Pro Asn Ala Leu Tyr 
    210                 215                 220                 

Val Ile Ala Gly Gln Thr His Pro Glu Ile Val Lys Arg Glu Gly Glu 
225                 230                 235                 240 

Ala Tyr Arg Glu Ser Leu Met Arg Arg Ile His Glu Leu His Leu Asp 
                245                 250                 255     

Asp His Val Val Met Leu Asn Gln Tyr Met Ser Glu Ser Asp Ile Val 
            260                 265                 270         

Asp Leu Ile Thr Ala Ala Asp Leu Tyr Val Thr Pro Tyr Pro Asn Met 
        275                 280                 285             

Glu Gln Ile Thr Ser Gly Thr Leu Ala Tyr Ala Val Gly Met Gly Gln 
    290                 295                 300                 

Val Val Leu Thr Thr Pro Tyr Ala Tyr Ala Arg Asp Leu Leu Lys Asp 
305                 310                 315                 320 

Val Pro Glu Leu Leu Val Pro Tyr Gly Asp Thr Arg Ala Trp Ala Asp 
                325                 330                 335     

Arg Ala Val Glu Ile Leu Thr Asn Arg Asp Val Arg Ala Lys Tyr Ala 
            340                 345                 350         

Glu Arg Ile Ser Ala Ile Gly Ala Asp Met Thr Trp Pro Lys Val Gly 
        355                 360                 365             

Glu Arg His Trp Gln Leu Phe Gln Asp Val Ala Leu Arg Ala Arg His 
    370                 375                 380                 

Arg Ala Ser Gly Val Lys Gly Phe Ala Val Ile Ala His 
385                 390                 395         

<210>   196
<211>   397
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 188

<400>   196
Met Thr Leu Glu Ile Gly Tyr Val Ser Thr Tyr Val Pro Arg Lys Cys 
                5                   10                  15      

Gly Leu Ala Thr Tyr Thr His His Leu Arg Gln Ser Val Arg Arg Ala 
            20                  25                  30          

Ala Gly Pro Ser Ala Ala Asp Gln Val Ile Ala Met Leu Ala Pro Asp 
        35                  40                  45              

Glu Asp Val Lys Asn Tyr Asn Arg Ser Tyr Trp Phe Leu Arg Arg Asp 
    50                  55                  60                  

Glu Arg Arg Asp Tyr Ala Arg Ile Ala Arg Arg Val Asn Asp Ser Arg 
65                  70                  75                  80  

Ile Gly Val Val Ser Leu Gln His Glu Phe Gly Ile Phe Gly Gly Glu 
                85                  90                  95      

Ala Gly Ser Tyr Ile Leu Asp Phe Ile Asp Ala Leu Asp Lys Pro Leu 
            100                 105                 110         

Val Thr Thr Phe His Thr Val Phe Gln Lys Pro Met Ser Pro Tyr Arg 
        115                 120                 125             

Glu Val Gln Lys Glu Ile Ala Glu Lys Ser Asp Arg Ile Val Val Met 
    130                 135                 140                 

Asn Arg Gln Ala Ile Asp Tyr Leu Val Asp Ala Phe Gly Ile Ser Pro 
145                 150                 155                 160 

Ser Lys Ile His Tyr Leu Pro His Gly Thr Pro Val Arg Ser Val Thr 
                165                 170                 175     

Pro Arg Ala Glu Leu Arg Lys Gln Phe Gly Trp Gln Asp Arg Ala Val 
            180                 185                 190         

Ile Val Thr Phe Gly Leu Leu Gly Pro Ser Lys Gly Ile Glu Phe Met 
        195                 200                 205             

Leu Asp Ala Met Pro Asp Ile Val Arg Glu Val Pro Asn Ala Leu Tyr 
    210                 215                 220                 

Val Ile Ala Gly Gln Thr His Pro Glu Ile Val Lys Arg Glu Gly Glu 
225                 230                 235                 240 

Ala Tyr Arg Glu Ser Leu Met Arg Arg Ile His Glu Leu His Leu Asp 
                245                 250                 255     

Asp His Val Val Met Leu Asn Gln Tyr Met Ser Glu Ser Asp Ile Val 
            260                 265                 270         

Asp Leu Ile Thr Ala Ala Asp Leu Tyr Val Thr Pro Tyr Pro Asn Met 
        275                 280                 285             

Glu Gln Ile Thr Ser Gly Thr Leu Ala Tyr Ala Val Gly Met Gly Gln 
    290                 295                 300                 

Val Val Leu Thr Thr Pro Tyr Ala Tyr Ala Arg Asp Leu Leu Lys Asp 
305                 310                 315                 320 

Val Pro Glu Leu Leu Val Pro Tyr Gly Asp Thr Arg Ala Trp Ala Asp 
                325                 330                 335     

Arg Ala Val Glu Ile Leu Thr Asn Arg Asp Val Arg Ala Lys Tyr Ala 
            340                 345                 350         

Glu Arg Ile Ser Ala Ile Gly Ala Asp Met Thr Trp Pro Arg Val Gly 
        355                 360                 365             

Glu Arg His Trp Gln Leu Phe Gln Asp Val Ala Leu Arg Ala Arg His 
    370                 375                 380                 

Arg Ala Ser Gly Val Lys Gly Phe Ala Val Ile Ala His 
385                 390                 395         

<210>   197
<211>   397
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 188

<400>   197
Met Thr Leu Glu Ile Gly Tyr Val Ser Thr Tyr Val Pro Arg Lys Cys 
                5                   10                  15      

Gly Leu Ala Thr Tyr Thr His His Leu Arg Gln Ser Val Arg Arg Ala 
            20                  25                  30          

Ala Gly Pro Ser Ala Ala Asp Gln Val Ile Ala Met Leu Ala Pro Asp 
        35                  40                  45              

Glu Asp Val Lys Asn Tyr Asn Arg Ser Tyr Trp Phe Leu Arg Arg Asp 
    50                  55                  60                  

Glu Arg Arg Asp Tyr Ala Arg Ile Ala Arg Arg Val Asn Asp Ser Arg 
65                  70                  75                  80  

Ile Gly Val Val Ser Leu Gln His Glu Phe Gly Ile Phe Gly Gly Glu 
                85                  90                  95      

Ala Gly Ser Tyr Ile Leu Asp Phe Ile Asp Ala Leu Asp Lys Pro Leu 
            100                 105                 110         

Val Thr Thr Phe His Thr Val Phe Gln Lys Pro Met Ser Pro Tyr Arg 
        115                 120                 125             

Glu Val Gln Lys Glu Ile Ala Glu Arg Ser Asp Arg Ile Val Val Met 
    130                 135                 140                 

Asn Arg Gln Ala Ile Asp Tyr Leu Val Asp Ala Phe Gly Ile Ser Pro 
145                 150                 155                 160 

Ser Lys Ile His Tyr Leu Pro His Gly Thr Pro Val Arg Ser Val Thr 
                165                 170                 175     

Pro Arg Ala Glu Leu Arg Lys Gln Phe Gly Trp Gln Asp Arg Ala Val 
            180                 185                 190         

Ile Val Thr Phe Gly Leu Leu Gly Pro Ser Lys Gly Ile Glu Phe Met 
        195                 200                 205             

Leu Asp Ala Met Pro Asp Ile Val Lys Glu Val Pro Asn Ala Leu Tyr 
    210                 215                 220                 

Val Ile Ala Gly Gln Thr His Pro Glu Ile Val Lys Arg Glu Gly Glu 
225                 230                 235                 240 

Ala Tyr Arg Glu Ser Leu Met Arg Arg Ile His Glu Leu His Leu Asp 
                245                 250                 255     

Asp His Val Val Met Leu Asn Gln Tyr Met Ser Glu Ser Asp Ile Val 
            260                 265                 270         

Asp Leu Ile Thr Ala Ala Asp Leu Tyr Val Thr Pro Tyr Pro Asn Met 
        275                 280                 285             

Glu Gln Ile Thr Ser Gly Thr Leu Ala Tyr Ala Val Gly Met Gly Gln 
    290                 295                 300                 

Val Val Leu Thr Thr Pro Tyr Ala Tyr Ala Arg Asp Leu Leu Lys Asp 
305                 310                 315                 320 

Val Pro Glu Leu Leu Val Pro Tyr Gly Asp Thr Arg Ala Trp Ala Asp 
                325                 330                 335     

Arg Ala Val Glu Ile Leu Thr Asn Arg Asp Val Arg Ala Lys Tyr Ala 
            340                 345                 350         

Glu Arg Ile Ser Ala Ile Gly Ala Asp Met Thr Trp Pro Arg Val Gly 
        355                 360                 365             

Glu Arg His Trp Gln Leu Phe Gln Asp Val Ala Leu Arg Ala Arg His 
    370                 375                 380                 

Arg Ala Ser Gly Val Lys Gly Phe Ala Val Ile Ala His 
385                 390                 395         

<210>   198
<211>   397
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 188

<400>   198
Met Thr Leu Glu Ile Gly Tyr Val Ser Thr Tyr Val Pro Arg Lys Cys 
                5                   10                  15      

Gly Leu Ala Thr Tyr Thr His His Leu Arg Gln Ser Val Arg Arg Ala 
            20                  25                  30          

Ala Gly Pro Ser Ala Ala Asp Gln Val Ile Ala Met Leu Ala Pro Asp 
        35                  40                  45              

Glu Asp Val Lys Asn Tyr Asn Arg Ser Tyr Trp Phe Leu Arg Arg Asp 
    50                  55                  60                  

Glu Arg Arg Asp Tyr Ala Arg Ile Ala Arg Arg Val Asn Asp Ser Arg 
65                  70                  75                  80  

Ile Gly Val Val Ser Leu Gln His Glu Phe Gly Ile Phe Gly Gly Glu 
                85                  90                  95      

Ala Gly Ser Tyr Ile Leu Asp Phe Ile Asp Ala Leu Asp Lys Pro Leu 
            100                 105                 110         

Val Thr Thr Phe His Thr Val Phe Gln Lys Pro Met Ser Pro Tyr Arg 
        115                 120                 125             

Glu Val Gln Lys Glu Ile Ala Glu Arg Ser Asp Arg Ile Val Val Met 
    130                 135                 140                 

Asn Arg Gln Ala Ile Asp Tyr Leu Val Asp Ala Phe Gly Ile Ser Pro 
145                 150                 155                 160 

Ser Lys Ile His Tyr Leu Pro His Gly Thr Pro Val Arg Ser Val Thr 
                165                 170                 175     

Pro Arg Ala Glu Leu Arg Lys Gln Phe Gly Trp Gln Asp Arg Ala Val 
            180                 185                 190         

Ile Val Thr Phe Gly Leu Leu Gly Pro Ser Lys Gly Ile Glu Phe Met 
        195                 200                 205             

Leu Asp Ala Met Pro Asp Ile Val Arg Glu Val Pro Asn Ala Leu Tyr 
    210                 215                 220                 

Val Ile Ala Gly Gln Thr His Pro Glu Ile Val Lys Arg Glu Gly Glu 
225                 230                 235                 240 

Ala Tyr Arg Glu Ser Leu Met Arg Arg Ile His Glu Leu His Leu Asp 
                245                 250                 255     

Asp His Val Val Met Leu Asn Gln Tyr Met Ser Glu Ser Asp Ile Val 
            260                 265                 270         

Asp Leu Ile Thr Ala Ala Asp Leu Tyr Val Thr Pro Tyr Pro Asn Met 
        275                 280                 285             

Glu Gln Ile Thr Ser Gly Thr Leu Ala Tyr Ala Val Gly Met Gly Gln 
    290                 295                 300                 

Val Val Leu Thr Thr Pro Tyr Ala Tyr Ala Arg Asp Leu Leu Lys Asp 
305                 310                 315                 320 

Val Pro Glu Leu Leu Val Pro Tyr Gly Asp Thr Arg Ala Trp Ala Asp 
                325                 330                 335     

Arg Ala Val Glu Ile Leu Thr Asn Arg Asp Val Arg Ala Lys Tyr Ala 
            340                 345                 350         

Glu Arg Leu Ser Ala Ile Gly Ala Asp Met Thr Trp Pro Arg Val Gly 
        355                 360                 365             

Glu Arg His Trp Gln Leu Phe Gln Asp Val Ala Leu Arg Ala Arg His 
    370                 375                 380                 

Arg Ala Ser Gly Val Lys Gly Phe Ala Val Ile Ala His 
385                 390                 395         

<210>   199
<211>   397
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 188

<400>   199
Met Thr Leu Glu Ile Gly Tyr Val Ser Thr Tyr Val Pro Arg Lys Cys 
                5                   10                  15      

Gly Leu Ala Thr Tyr Thr His His Leu Arg Gln Ser Val Arg Arg Ala 
            20                  25                  30          

Ala Gly Pro Ser Ala Ala Asp Gln Val Ile Ala Met Leu Ala Pro Asp 
        35                  40                  45              

Glu Asp Val Lys Asn Tyr Asn Arg Ser Tyr Trp Phe Leu Lys Arg Asp 
    50                  55                  60                  

Glu Arg Arg Asp Tyr Ala Arg Ile Ala Arg Arg Val Asn Asp Ser Arg 
65                  70                  75                  80  

Ile Gly Val Val Ser Leu Gln His Glu Phe Gly Ile Phe Gly Gly Glu 
                85                  90                  95      

Ala Gly Ser Tyr Ile Leu Asp Phe Ile Asp Ala Leu Asp Lys Pro Leu 
            100                 105                 110         

Val Thr Thr Phe His Thr Val Phe Gln Lys Pro Met Ser Pro Tyr Arg 
        115                 120                 125             

Glu Val Gln Lys Glu Ile Ala Glu Arg Ser Asp Arg Ile Val Val Met 
    130                 135                 140                 

Asn Arg Gln Ala Ile Asp Tyr Leu Val Asp Ala Phe Gly Ile Ser Pro 
145                 150                 155                 160 

Ser Lys Ile His Tyr Leu Pro His Gly Thr Pro Val Arg Ser Val Thr 
                165                 170                 175     

Pro Arg Ala Glu Leu Arg Lys Gln Phe Gly Trp Gln Asp Arg Ala Val 
            180                 185                 190         

Ile Val Thr Phe Gly Leu Leu Gly Pro Ser Lys Gly Ile Glu Phe Met 
        195                 200                 205             

Leu Asp Ala Met Pro Asp Ile Val Arg Glu Val Pro Asn Ala Leu Tyr 
    210                 215                 220                 

Val Ile Ala Gly Gln Thr His Pro Glu Ile Val Lys Arg Glu Gly Glu 
225                 230                 235                 240 

Ala Tyr Arg Glu Ser Leu Met Arg Arg Ile His Glu Leu His Leu Asp 
                245                 250                 255     

Asp His Val Val Met Leu Asn Gln Tyr Met Ser Glu Ser Asp Ile Val 
            260                 265                 270         

Asp Leu Ile Thr Ala Ala Asp Leu Tyr Val Thr Pro Tyr Pro Asn Met 
        275                 280                 285             

Glu Gln Ile Thr Ser Gly Thr Leu Ala Tyr Ala Val Gly Met Gly Gln 
    290                 295                 300                 

Val Val Leu Thr Thr Pro Tyr Ala Tyr Ala Arg Asp Leu Leu Lys Asp 
305                 310                 315                 320 

Val Pro Glu Leu Leu Val Pro Tyr Gly Asp Thr Arg Ala Trp Ala Asp 
                325                 330                 335     

Arg Ala Val Glu Ile Leu Thr Asn Arg Asp Val Arg Ala Lys Tyr Ala 
            340                 345                 350         

Glu Arg Ile Ser Ala Ile Gly Ala Asp Met Thr Trp Pro Arg Val Gly 
        355                 360                 365             

Glu Arg His Trp Gln Leu Phe Gln Asp Val Ala Leu Arg Ala Arg His 
    370                 375                 380                 

Arg Ala Ser Gly Val Lys Gly Phe Ala Val Ile Ala His 
385                 390                 395         

<210>   200
<211>   1194
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 189

<400>   200
atgacgttgg aaatcggata tgtcagcact tatgtccccc ggaaatgcgg acttgccaca       60

tatacacacc atttgcgcca gagcgttcgc cgggcggcgg gaccgtccgc ggccgaccag      120

gtcatcgcca tgttggcccc ggatgaggac gtgaagaact acaaccgctc gtactggttc      180

cttcgccggg atgagcgcag ggattacgcg cgcattgcac ggcgggtgaa cgacagccga      240

attggcgtgg tctccctgca gcacgaattc ggcatctttg gcggcgaagc agggtcgtac      300

atcctcgact tcattgacgc gctggacaaa ccgctcgtga cgacgtttca caccgtcttt      360

caaaagccca tgtcgcctta tcgcgaagtg cagaaggaga tcgccgagag aagcgaccgc      420

atcgtcgtga tgaatcgaca ggccatcgat tatctcgtcg acgcattcgg catctcgccg      480

tcgaagatcc actatctccc gcacggcacg ccggtgcgat ctgtgacgcc gcgggccgag      540

ttgcggaagc agttcggttg gcaagaccgg gccgtgatcg tcacctttgg gctgctcggt      600

ccgagcaagg gcattgagtt catgttggat gcgatgccgg acatcgtgcg cgaggttccg      660

aacgcgctgt acgtgatcgc cggacagacg cacccggaaa ttgtcaagcg cgagggcgag      720

gcgtaccgcg agtcgctcat gcggcgaatc catgagctcc acttggacga tcacgtcgtg      780

atgctgaacc agtacatgtc cgagtccgac atcgtggatc ttatcacggc ggcggatctc      840

tacgtcacgc cttatccgaa catggagcag attacgagcg ggacgctggc ctacgcggtc      900

ggcatggggc aggtcgtgct gacgacgccg tacgcgtacg cgcgcgacct tctgaaggac      960

gtgccggaac tgctcgtgcc ctacggggac acgcgcgcgt gggcggatcg ggctgtggaa     1020

atcctgacga accgcgatgt gcgcgcgaag tacgcggagc ggatttcggc gattggggca     1080

gacatgacgt ggccgaaagt gggcgagcgc cattggcagt tgttccagga cgtcgccctg     1140

cgggctcgcc atcgcgcatc gggggtgaag ggatttgcgg tcatcgcaca ctga           1194


<210>   201
<211>   1194
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 189

<400>   201
atgacgttgg aaatcggata tgtcagcact tatgtccccc ggaaatgcgg acttgccaca       60

tatacacacc atttgcgcca gagcgttcgc cgggcggcgg gaccgtccgc ggccgaccag      120

gtcatcgcca tgttggcccc ggatgaggac gtgaagaact acaaccgctc gtactggttc      180

cttcgccggg atgagcgcag ggattacgcg cgcattgcac ggcgggtgaa cgacagccga      240

attggcgtgg tctccctgca gcacgaattc ggcatctttg gcggcgaagc agggtcgtac      300

atcctcgact tcattgacgc gctggacaaa ccgctcgtga cgacgtttca caccgtcttt      360

caaaagccca tgtcgcctta tcgcgaagtg cagaaggaga tcgccgagaa aagcgaccgc      420

atcgtcgtga tgaatcgaca ggccatcgat tatctcgtcg acgcattcgg catctcgccg      480

tcgaagatcc actatctccc gcacggcacg ccggtgcgat ctgtgacgcc gcgggccgag      540

ttgcggaagc agttcggttg gcaagaccgg gccgtgatcg tcacctttgg gctgctcggt      600

ccgagcaagg gcattgagtt catgttggat gcgatgccgg acatcgtgcg cgaggttccg      660

aacgcgctgt acgtgatcgc cggacagacg cacccggaaa ttgtcaagcg cgagggcgag      720

gcgtaccgcg agtcgctcat gcggcgaatc catgagctcc acttggacga tcacgtcgtg      780

atgctgaacc agtacatgtc cgagtccgac atcgtggatc ttatcacggc ggcggatctc      840

tacgtcacgc cttatccgaa catggagcag attacgagcg ggacgctggc ctacgcggtc      900

ggcatggggc aggtcgtgct gacgacgccg tacgcgtacg cgcgcgacct tctgaaggac      960

gtgccggaac tgctcgtgcc ctacggggac acgcgcgcgt gggcggatcg ggctgtggaa     1020

atcctgacga accgcgatgt gcgcgcgaag tacgcggagc ggatttcggc gattggggca     1080

gacatgacgt ggccgcgcgt gggcgagcgc cattggcagt tgttccagga cgtcgccctg     1140

cgggctcgcc atcgcgcatc gggggtgaag ggatttgcgg tcatcgcaca ctga           1194


<210>   202
<211>   1194
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 189

<400>   202
atgacgttgg aaatcggata tgtcagcact tatgtccccc ggaaatgcgg acttgccaca       60

tatacacacc atttgcgcca gagcgttcgc cgggcggcgg gaccgtccgc ggccgaccag      120

gtcatcgcca tgttggcccc ggatgaggac gtgaagaact acaaccgctc gtactggttc      180

cttcgccggg atgagcgcag ggattacgcg cgcattgcac ggcgggtgaa cgacagccga      240

attggcgtgg tctccctgca gcacgaattc ggcatctttg gcggcgaagc agggtcgtac      300

atcctcgact tcattgacgc gctggacaaa ccgctcgtga cgacgtttca caccgtcttt      360

caaaagccca tgtcgcctta tcgcgaagtg cagaaggaga tcgccgagag aagcgaccgc      420

atcgtcgtga tgaatcgaca ggccatcgat tatctcgtcg acgcattcgg catctcgccg      480

tcgaagatcc actatctccc gcacggcacg ccggtgcgat ctgtgacgcc gcgggccgag      540

ttgcggaagc agttcggttg gcaagaccgg gccgtgatcg tcacctttgg gctgctcggt      600

ccgagcaagg gcattgagtt catgttggat gcgatgccgg acatcgtgaa agaggttccg      660

aacgcgctgt acgtgatcgc cggacagacg cacccggaaa ttgtcaagcg cgagggcgag      720

gcgtaccgcg agtcgctcat gcggcgaatc catgagctcc acttggacga tcacgtcgtg      780

atgctgaacc agtacatgtc cgagtccgac atcgtggatc ttatcacggc ggcggatctc      840

tacgtcacgc cttatccgaa catggagcag attacgagcg ggacgctggc ctacgcggtc      900

ggcatggggc aggtcgtgct gacgacgccg tacgcgtacg cgcgcgacct tctgaaggac      960

gtgccggaac tgctcgtgcc ctacggggac acgcgcgcgt gggcggatcg ggctgtggaa     1020

atcctgacga accgcgatgt gcgcgcgaag tacgcggagc ggatttcggc gattggggca     1080

gacatgacgt ggccgcgcgt gggcgagcgc cattggcagt tgttccagga cgtcgccctg     1140

cgggctcgcc atcgcgcatc gggggtgaag ggatttgcgg tcatcgcaca ctga           1194


<210>   203
<211>   1194
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 189

<400>   203
atgacgttgg aaatcggata tgtcagcact tatgtccccc ggaaatgcgg acttgccaca       60

tatacacacc atttgcgcca gagcgttcgc cgggcggcgg gaccgtccgc ggccgaccag      120

gtcatcgcca tgttggcccc ggatgaggac gtgaagaact acaaccgctc gtactggttc      180

cttcgccggg atgagcgcag ggattacgcg cgcattgcac ggcgggtgaa cgacagccga      240

attggcgtgg tctccctgca gcacgaattc ggcatctttg gcggcgaagc agggtcgtac      300

atcctcgact tcattgacgc gctggacaaa ccgctcgtga cgacgtttca caccgtcttt      360

caaaagccca tgtcgcctta tcgcgaagtg cagaaggaga tcgccgagag aagcgaccgc      420

atcgtcgtga tgaatcgaca ggccatcgat tatctcgtcg acgcattcgg catctcgccg      480

tcgaagatcc actatctccc gcacggcacg ccggtgcgat ctgtgacgcc gcgggccgag      540

ttgcggaagc agttcggttg gcaagaccgg gccgtgatcg tcacctttgg gctgctcggt      600

ccgagcaagg gcattgagtt catgttggat gcgatgccgg acatcgtgcg cgaggttccg      660

aacgcgctgt acgtgatcgc cggacagacg cacccggaaa ttgtcaagcg cgagggcgag      720

gcgtaccgcg agtcgctcat gcggcgaatc catgagctcc acttggacga tcacgtcgtg      780

atgctgaacc agtacatgtc cgagtccgac atcgtggatc ttatcacggc ggcggatctc      840

tacgtcacgc cttatccgaa catggagcag attacgagcg ggacgctggc ctacgcggtc      900

ggcatggggc aggtcgtgct gacgacgccg tacgcgtacg cgcgcgacct tctgaaggac      960

gtgccggaac tgctcgtgcc ctacggggac acgcgcgcgt gggcggatcg ggctgtggaa     1020

atcctgacga accgcgatgt gcgcgcgaag tacgcggagc ggttatcggc gattggggca     1080

gacatgacgt ggccgcgcgt gggcgagcgc cattggcagt tgttccagga cgtcgccctg     1140

cgggctcgcc atcgcgcatc gggggtgaag ggatttgcgg tcatcgcaca ctga           1194


<210>   204
<211>   1194
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 189

<400>   204
atgacgttgg aaatcggata tgtcagcact tatgtccccc ggaaatgcgg acttgccaca       60

tatacacacc atttgcgcca gagcgttcgc cgggcggcgg gaccgtccgc ggccgaccag      120

gtcatcgcca tgttggcccc ggatgaggac gtgaagaact acaaccgctc gtactggttc      180

cttaaacggg atgagcgcag ggattacgcg cgcattgcac ggcgggtgaa cgacagccga      240

attggcgtgg tctccctgca gcacgaattc ggcatctttg gcggcgaagc agggtcgtac      300

atcctcgact tcattgacgc gctggacaaa ccgctcgtga cgacgtttca caccgtcttt      360

caaaagccca tgtcgcctta tcgcgaagtg cagaaggaga tcgccgagag aagcgaccgc      420

atcgtcgtga tgaatcgaca ggccatcgat tatctcgtcg acgcattcgg catctcgccg      480

tcgaagatcc actatctccc gcacggcacg ccggtgcgat ctgtgacgcc gcgggccgag      540

ttgcggaagc agttcggttg gcaagaccgg gccgtgatcg tcacctttgg gctgctcggt      600

ccgagcaagg gcattgagtt catgttggat gcgatgccgg acatcgtgcg cgaggttccg      660

aacgcgctgt acgtgatcgc cggacagacg cacccggaaa ttgtcaagcg cgagggcgag      720

gcgtaccgcg agtcgctcat gcggcgaatc catgagctcc acttggacga tcacgtcgtg      780

atgctgaacc agtacatgtc cgagtccgac atcgtggatc ttatcacggc ggcggatctc      840

tacgtcacgc cttatccgaa catggagcag attacgagcg ggacgctggc ctacgcggtc      900

ggcatggggc aggtcgtgct gacgacgccg tacgcgtacg cgcgcgacct tctgaaggac      960

gtgccggaac tgctcgtgcc ctacggggac acgcgcgcgt gggcggatcg ggctgtggaa     1020

atcctgacga accgcgatgt gcgcgcgaag tacgcggagc ggatttcggc gattggggca     1080

gacatgacgt ggccgcgcgt gggcgagcgc cattggcagt tgttccagga cgtcgccctg     1140

cgggctcgcc atcgcgcatc gggggtgaag ggatttgcgg tcatcgcaca ctga           1194


<210>   205
<211>   404
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   205
Met Arg Ser Ser His Thr Asp Gly Leu Pro Val Ser Leu Asp His Leu 
                5                   10                  15      

Arg Arg Met Thr Asp Asp Thr Gly Leu Ile Glu His Ala Ile Gly Arg 
            20                  25                  30          

Ile Pro Arg Arg Gln Glu Gly Tyr Ser Thr Asp Asp Asn Ala Arg Ala 
        35                  40                  45              

Leu Trp Leu Ala Tyr Glu Trp Leu His Tyr Ala Arg Glu Arg Gly Leu 
    50                  55                  60                  

Glu Ala Glu Ala Ala Asp Leu Ala Arg Leu Ile Asp Ile Tyr Phe Ala 
65                  70                  75                  80  

Phe Leu Ala Trp Val Gln Lys Pro Asp Gly Trp Phe His Asn Asn Val 
                85                  90                  95      

Ser Tyr Asp Arg Arg Phe Glu Leu Glu Val Pro Ser Asp Asp Cys Gln 
            100                 105                 110         

Gly Arg Ser Val Tyr Ala Leu Ala Val Gly Met Cys Glu Glu Arg Asp 
        115                 120                 125             

Pro Ala Arg Leu Thr Ala Tyr Ala Gln Val Leu Arg Arg Gly Leu Glu 
    130                 135                 140                 

Ala Ala Leu Arg Leu Thr His Ala Arg Gly Val Ala His Val Val Ala 
145                 150                 155                 160 

Ala Ala Ala Arg Leu Leu Arg His Ala Glu Gly Val Glu Leu Pro Glu 
                165                 170                 175     

Asp Ala Ala Pro Glu Phe Trp Ala Phe Val Arg Gln Arg Leu Pro Gly 
            180                 185                 190         

Val Val Glu Arg Gly Ala Arg Asp Leu Val Ser Arg Phe Glu Ala His 
        195                 200                 205             

Ala Arg Gly Asp Trp Pro Trp Phe Glu Asp Arg Met Thr Tyr Asp Asn 
    210                 215                 220                 

Ala Val Met Pro Trp Ala Leu Phe Glu Ala Tyr Ala Leu Thr Gly Glu 
225                 230                 235                 240 

Ala Arg Trp Arg Glu Val Ala Glu Ala Ser Leu Asp Gly Leu Leu Ala 
                245                 250                 255     

Arg Met Arg Ala Pro Glu Gly Trp Leu Arg Pro Ile Gly Asn Arg Gly 
            260                 265                 270         

Phe Ala Ala Pro Gly Phe Thr Ala Ile Trp Asp Gln Gln Pro Leu Glu 
        275                 280                 285             

Ile Ala Gln Leu Ala Ile Ala Cys Glu Ser Ala Trp Arg Ala Thr Gly 
    290                 295                 300                 

Asp Thr Ala Tyr Arg Arg Leu Thr Ala Glu Cys Gln Arg Trp Phe Tyr 
305                 310                 315                 320 

Gly Glu Asn Asp Lys Gly Val Pro Met Ala Asp Pro Ala Asp Gly Ser 
                325                 330                 335     

Cys Cys Asp Gly Leu Thr Pro Gln Gly Pro Asn Leu Asn Arg Gly Ala 
            340                 345                 350         

Glu Ser Thr Trp Ser Tyr Leu Ile Thr Glu Ile His Val Glu Arg Ala 
        355                 360                 365             

Phe Ala Asp Asp Leu Asp Ala Ala Arg Ala Phe Gly Ala Trp Val Gly 
    370                 375                 380                 

Val Pro Arg Gln Thr Leu Val Ser Ala Arg Ser Arg Arg Ala Leu Gly 
385                 390                 395                 400 

Gly Phe His Arg 
                

<210>   206
<211>   1215
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   206
ttgcggtcat cgcacactga tgggctgccg gtttcgctgg atcacctgcg ccggatgaca       60

gacgacacag ggctcattga acacgcgatt ggccgcattc ctcgccgtca ggaagggtat      120

tccaccgacg acaacgcgcg ggcgctctgg ctcgcgtacg agtggctcca ctacgcccgc      180

gagcggggcc tggaggcgga ggcggccgat ctcgcgcggc tcatcgacat ctacttcgcg      240

tttttggcct gggtccagaa gcccgacggc tggttccaca acaacgtgtc gtacgatcgc      300

cgctttgagc tggaggttcc gtcggacgac tgccaaggga ggtccgtgta cgcgctggcg      360

gtgggcatgt gcgaggagcg cgatccggcc cgcctgacgg cctacgcgca agtgcttcgc      420

cggggccttg aggcagccct taggctcacg cacgcacgcg gcgtcgccca tgtcgtagcg      480

gccgccgcaa ggcttttgcg ccacgcagag ggggtcgagc ttcccgaaga cgcggcgccc      540

gagttctggg cctttgtccg tcagcgcctg ccgggcgtcg tggagcgcgg cgctcgcgat      600

ctcgtgtcgc ggttcgaggc gcacgcacgc ggcgactggc cttggttcga ggaccgcatg      660

acgtacgaca acgcggtcat gccctgggcg ctcttcgaag cctatgcgct caccggcgag      720

gcccgatgga gagaagtcgc ggaagcctcg ctcgacgggc ttctcgcccg catgcgtgcg      780

cccgagggat ggcttcggcc cattggcaac cgcggcttcg cggcgcctgg cttcaccgcc      840

atttgggacc agcagccgct ggaaatcgcc cagctcgcca ttgcgtgcga atcggcctgg      900

cgcgcgacgg gtgacacggc ctatcggcgg cttacggccg agtgccagcg ctggttctac      960

ggtgaaaacg acaaaggggt gccgatggcc gatccggccg acggcagttg ctgcgacggc     1020

ctgacgccgc agggtcccaa cctgaaccgc ggtgcagagt cgacgtggtc gtacctcatc     1080

accgagatcc acgtcgagcg ggcatttgcc gatgatctgg acgccgcgcg ggcgttcggc     1140

gcgtgggtgg gcgttccgcg ccagaccctc gtgtccgcac ggtcgagacg ggcgctcggc     1200

ggctttcacc ggtga                                                      1215


<210>   207
<211>   337
<212>   PRT
<213>   Geobacillus kaustophilus HTA426

<400>   207
Ile Lys Phe Asp His Leu Glu Arg Met Thr Asp Asp Thr Gly Leu Leu 
                5                   10                  15      

Glu His Ser Leu Gly Arg Ile Pro Arg Arg Arg Glu Gly Tyr Ser Thr 
            20                  25                  30          

Asp Asp Asn Ala Arg Ala Ile Trp Ala Cys Leu Glu Trp Met Ala Leu 
        35                  40                  45              

Cys Glu Asp Lys Gly Glu Lys Glu Arg Leu His Arg Leu Leu Asp Arg 
    50                  55                  60                  

Tyr Leu Ala Phe Leu Leu Trp Ala Gln Asn Asp Asp Gly Thr Phe His 
65                  70                  75                  80  

Asn Asn Phe Phe Phe Asp Arg Thr Lys Glu Glu Glu Thr Pro Ser Asp 
                85                  90                  95      

Asp Cys Phe Gly Arg Ser Phe Trp Ala Thr Ala Leu Ala Tyr Val Arg 
            100                 105                 110         

Leu Ser Asp Pro Ala Arg Arg Glu Ala Ala Ala Asp Met Leu Arg Arg 
        115                 120                 125             

Ala Met Pro Ala Ala Trp Glu Leu Arg Ser Leu Arg Gly Val Ala Trp 
    130                 135                 140                 

Gly Val Ala Thr Cys Gly Val Leu Leu Thr Glu Gly Arg Pro Leu Gly 
145                 150                 155                 160 

Val Asp Gln Glu Glu Val Ala Ala Leu Ala Ala Arg Leu Glu Gln Arg 
                165                 170                 175     

Leu Leu Ala Ala Tyr Trp Glu His Ala Gly Asp Asp Trp Tyr Trp Tyr 
            180                 185                 190         

Glu Pro Glu Leu Thr Tyr Ala Asn Gly Val Leu Pro Trp Ala Leu Trp 
        195                 200                 205             

Thr Ala Tyr Arg Arg Ala Pro Arg Asp Glu Val Lys Glu Val Ala Glu 
    210                 215                 220                 

Lys Ser Leu Ala Phe Leu Ile Glu Lys Met Ser Gly Pro Gly Gly Val 
225                 230                 235                 240 

Ile Arg Pro Val Gly Asn Arg Gly Trp Cys Ser Arg Arg Tyr Arg Ala 
                245                 250                 255     

Asp Trp Asp Gln Gln Pro Leu Asp Val Met Lys Leu Ala Leu Ala Ala 
            260                 265                 270         

Arg Glu Ala Tyr Trp Ala Thr Asp Asp Glu Arg Tyr Arg Gly Val Val 
        275                 280                 285             

Arg Arg Cys Leu Ala Trp Phe Tyr Gly Gln Asn Asp Gly Asn Ala Pro 
    290                 295                 300                 

Leu Ala Asp Pro Ser Asp Gly Ser Cys Cys Asp Gly Leu Gly Pro Asn 
305                 310                 315                 320 

Gly Pro Asn Pro Asn Arg Gly Ala Glu Ser Thr Leu Ser Tyr Leu Leu 
                325                 330                 335     

Thr 
    

<210>   208
<211>   329
<212>   PRT
<213>   Geobacillus thermodenitrificans NG80-2

<400>   208
Met Thr Asp Asp Thr Gly Leu Leu Glu His Ser Leu Gly Arg Ile Pro 
                5                   10                  15      

Arg Arg Arg Glu Gly Tyr Ser Thr Asp Asp Asn Ala Arg Ala Ile Trp 
            20                  25                  30          

Ala Cys Leu Glu Trp Leu Ala Leu Leu Lys Asn Arg Glu Met Glu Lys 
        35                  40                  45              

Arg Leu Tyr Arg Leu Leu Asp Arg Tyr Leu Ala Phe Leu Leu Trp Ala 
    50                  55                  60                  

Gln Asn Asp Asp Gly Thr Phe His Asn Asn Phe Phe Phe Asp Arg Thr 
65                  70                  75                  80  

Lys Glu Glu Glu Thr Pro Ser Asp Asp Cys Leu Gly Arg Ser Phe Trp 
                85                  90                  95      

Ala Val Ala Ser Ala Tyr Ile Gln Leu Asn Asp Pro Ala Arg Cys Glu 
            100                 105                 110         

Ala Ala Ala Asp Met Leu Arg Arg Gly Met Pro Ala Ala Trp Lys Leu 
        115                 120                 125             

His Ser Leu Arg Gly Ile Ala Trp Gly Leu Ala Ala Cys Gly Leu Leu 
    130                 135                 140                 

Leu Glu Lys Ala Ser Pro Pro Gly Val Asp Lys Glu Glu Leu Ala Thr 
145                 150                 155                 160 

Leu Ala Gly Arg Phe Glu Arg Arg Leu Leu Glu Ala Tyr Trp Thr His 
                165                 170                 175     

Thr Asp Asp Gly Trp Arg Trp Tyr Glu Pro Glu Leu Thr Tyr Gly Asn 
            180                 185                 190         

Gly Val Leu Pro Trp Ala Leu Trp Thr Ala Tyr Arg Arg Ala Pro Arg 
        195                 200                 205             

Gln Glu Val Arg Glu Val Ala Glu Glu Ser Leu Ala Phe Leu Ile Glu 
    210                 215                 220                 

Met Met Ser Gly Pro Glu Gly Thr Ile Arg Pro Val Gly Asn Arg Gly 
225                 230                 235                 240 

Trp Cys Ser Arg Arg Tyr Arg Ala Asp Trp Asp Gln Gln Pro Ile Asp 
                245                 250                 255     

Val Met Lys Leu Ala Leu Ala Ala Arg Glu Ala Tyr Trp Ala Thr Glu 
            260                 265                 270         

Asp Glu Arg Tyr Arg Asp Val Val Arg Arg Cys Leu Ala Trp Phe Tyr 
        275                 280                 285             

Gly Lys Asn Asp Gly Asn Val Pro Leu Ala Asp Arg Ser Asp Gly Ser 
    290                 295                 300                 

Cys Cys Asp Gly Leu Gly Pro Asn Gly Pro Asn Pro Asn Arg Gly Ala 
305                 310                 315                 320 

Glu Ser Thr Leu Ser Tyr Leu Leu Thr 
                325                 

<210>   209
<211>   339
<212>   PRT
<213>   Symbiobacterium thermophilum IAM 14863

<400>   209
Leu Ser His Leu Gln Arg Leu Thr Asp Pro Thr Gly Val Ile Gln His 
                5                   10                  15      

Ala Val Gly Pro Ile Pro Asn Leu Thr Thr Gly Tyr Thr Ser Asp Asp 
            20                  25                  30          

Asn Ala Arg Ala Leu Leu Val Ser Val Trp Ala Ala Arg Ala Gly Glu 
        35                  40                  45              

Ala Thr Ala Gln Leu Ser Glu Thr Tyr Leu Ala Phe Leu Ala Tyr Ala 
    50                  55                  60                  

Gln Arg Pro Asp Gly Trp Phe His Asn Ala Phe Ser Tyr Asp Arg Asn 
65                  70                  75                  80  

Pro Leu Ala Glu Asp Arg Ser Glu Asp Cys Gln Ala Arg Cys Leu Trp 
                85                  90                  95      

Gly Leu Ala Ala Ala Ala Thr Gln Leu Gly Gly Ser Ser Val Ala Trp 
            100                 105                 110         

Thr Ala Ala His Leu Phe Arg Arg Gly Leu Ala Pro Cys Gly Ser Val 
        115                 120                 125             

Arg Thr Leu Arg Gly Arg Ala Gly Val Ala Val Ala Met Ala Glu Trp 
    130                 135                 140                 

Leu Glu His Arg Arg Ala Asp Gly Arg Pro Asp Gly Ala Pro Thr Asp 
145                 150                 155                 160 

Asp Glu Val Arg Ala His Leu Ile Arg Ala Ala Asp Gly Leu Thr Asp 
                165                 170                 175     

Ala Trp Lys Gln His Ala Thr Arg Asp Trp Ala Trp Phe Glu Asp Arg 
            180                 185                 190         

Leu Thr Tyr Asp Asn Ala Leu Leu Pro Tyr Ala Leu Leu Arg Ala Gly 
        195                 200                 205             

Arg Ile Leu Asp Val Pro Glu Tyr Arg Arg Ile Gly Leu Thr Ala Leu 
    210                 215                 220                 

Glu Phe Leu Ala Gly Ala Thr Phe Arg Asp Gly Val Phe Trp Pro Ile 
225                 230                 235                 240 

Gly Asn Asp Gly Trp Tyr Val Arg Gly Gly Arg Arg Ala Glu Phe Asp 
                245                 250                 255     

Gln Gln Pro Leu Glu Ala Thr Ala Met Val Leu Ala Cys Gln Glu Ala 
            260                 265                 270         

Gly Ala Val Thr Gly Asp Lys Val Trp His Gly Met Ala Leu Asp Ala 
        275                 280                 285             

Ala Arg Trp Phe Thr Gly Arg Asn Ala Leu Gly Val Pro Leu Leu Asp 
    290                 295                 300                 

Pro Glu Thr Gly Gly Cys His Asp Gly Leu Asn Pro His Gly Val Asn 
305                 310                 315                 320 

Arg Asn Gln Gly Ala Glu Ser Thr Leu Ala Trp Leu Met Ala Ala Tyr 
                325                 330                 335     

Gly Leu Glu 
            

<210>   210
<211>   322
<212>   PRT
<213>   Clostridium thermocellum ATCC 27405

<400>   210
Asp His Ile Phe Arg Met Thr Asp Asp Thr Gly Met Leu Gln His Ser 
                5                   10                  15      

Lys Tyr Ser Leu Pro Asp Pro Asn His Gly Tyr Thr Thr Asp Asp Asn 
            20                  25                  30          

Ala Arg Ala Leu Ile Met Ala Leu Met Leu Tyr Lys Lys Tyr Gly Glu 
        35                  40                  45              

Lys Lys Tyr Leu Asp Leu Val Tyr Arg Tyr Ser Ser Phe Leu Leu Asn 
    50                  55                  60                  

Ala Gln Asn Glu Lys Gly Lys Phe Lys Asn Phe Met Gly Tyr Asp Arg 
65                  70                  75                  80  

Lys Trp Leu Glu Asp Glu Gly Ser Glu Asp Cys Phe Gly Arg Cys Leu 
                85                  90                  95      

Trp Ala Ile Gly Phe Ala Leu Ser Gly Asp Phe Thr Pro Arg Gly Val 
            100                 105                 110         

Lys His Ala Leu Leu Glu Ile Phe Asn Lys Ala Met Pro His Ala Ala 
        115                 120                 125             

Asn Leu Ser Tyr Leu Arg Gly Lys Ala Tyr Ser Ala Ile Gly Leu Ser 
    130                 135                 140                 

Phe Phe Asp Gly Asp Asp Ser Lys Glu Leu Val Phe Ser Ile Ala Gln 
145                 150                 155                 160 

Ser Leu Cys Cys Gln Tyr Asp Glu His Lys Asp Gly Glu Trp Lys Trp 
                165                 170                 175     

Phe Glu Asp Val Val Ser Tyr Cys Asn Ser Val Leu Pro Trp Ser Leu 
            180                 185                 190         

Leu Thr Ala Tyr Lys Val Thr Gly Glu Lys Arg Phe Leu Glu Thr Ala 
        195                 200                 205             

Glu Glu Ser Leu Asp Phe Leu Gly Lys Ile Thr Phe Lys Asp Gly Tyr 
    210                 215                 220                 

Phe Lys Pro Val Gly Cys Asn Gly Trp Phe Lys Lys Gly Lys Glu Gln 
225                 230                 235                 240 

Ala Glu Phe Asp Glu Gln Pro Val Glu Ala Cys Glu Ala Val Leu Thr 
                245                 250                 255     

Tyr Leu Glu Ala Phe Glu Leu Thr Gly Lys Thr Lys Tyr Leu Glu Lys 
            260                 265                 270         

Ala Lys Ile Cys Asn Ala Trp Tyr Ser Gly Met Asn Ser Lys Gly Ile 
        275                 280                 285             

Pro Leu Val Asp Pro Glu Thr Gly Gly Cys Tyr Asp Gly Leu Thr Gln 
    290                 295                 300                 

Lys Gly Val Asn Leu Asn Met Gly Ala Glu Ser Leu Val Ser Tyr Ile 
305                 310                 315                 320 

Ile Ser 
        

<210>   211
<211>   333
<212>   PRT
<213>   Thermoanaerobacter tengcongensis MB4

<400>   211
His Leu Phe Thr Leu Thr Asp Asp Thr Gly Ile Phe Gln His Ser Leu 
                5                   10                  15      

Tyr Ser Ile Pro Asp Pro Ser Lys Gly Tyr Thr Thr Asp Asp Asn Ala 
            20                  25                  30          

Arg Ala Ala Ile Ala Ala Thr Met Leu Tyr Gln Val Tyr Arg Glu Glu 
        35                  40                  45              

Val Tyr Leu Ser Leu Leu Arg Arg Tyr Leu Ser Phe Leu Ile Tyr Ala 
    50                  55                  60                  

Gln Asn Glu Glu Gly Phe Phe Arg Asn Phe Met Asn Tyr Asn Arg Glu 
65                  70                  75                  80  

Phe Thr Glu Lys Lys Gly Ser Glu Asp Cys Phe Gly Arg Ser Leu Trp 
                85                  90                  95      

Ala Leu Gly Tyr Leu Leu Asn Val Pro Phe Ser Asp Glu Ser Tyr His 
            100                 105                 110         

Asn Val Ala Ile Arg Leu Leu Glu Lys Ala Leu Phe Asn Val Lys Lys 
        115                 120                 125             

Leu Tyr Ser Leu Arg Gly Lys Ala Tyr Ser Leu Ile Gly Leu Ser Leu 
    130                 135                 140                 

Ile Tyr Asn Ser Glu Ala Phe Glu Phe Asp Arg Gly Glu Ile Arg Asp 
145                 150                 155                 160 

Leu Val Lys Ser Leu Ser Gln Asp Leu Leu Lys Ser Tyr Tyr Lys Asn 
                165                 170                 175     

Arg Glu Glu Asn Trp Lys Trp Phe Glu Asp Gln Met Thr Tyr Ser Asn 
            180                 185                 190         

Ala Ile Leu Pro Trp Ser Leu Leu Lys Ala Tyr Thr Val Thr Lys Asp 
        195                 200                 205             

Glu Glu Val Leu Arg Val Ala Lys Glu Ser Met Asp Phe Leu Gly Ser 
    210                 215                 220                 

Val Thr Phe Lys Asp Gly Tyr Phe Lys Pro Ile Gly Cys Lys Gly Trp 
225                 230                 235                 240 

Tyr Lys Lys Gly Gly Lys Arg Ala Glu Phe Asp Glu Gln Pro Ile Glu 
                245                 250                 255     

Ala Cys Glu Ser Ala Leu Met Tyr Ile Glu Ala Tyr Arg Val Phe Gly 
            260                 265                 270         

Glu Glu Glu Tyr Leu Asn Lys Ala Lys Lys Cys Tyr Arg Trp Phe Leu 
        275                 280                 285             

Gly Glu Asn Ser Gln Asn Ile Ser Leu Val Asp Glu Glu Thr Gly Gly 
    290                 295                 300                 

Cys Tyr Asp Gly Ile Thr Glu Asp Gly Val Asn Leu Asn Glu Gly Ala 
305                 310                 315                 320 

Glu Ser Leu Ile Ser Leu Ile Met Thr Asp Met Val Val 
                325                 330             

<210>   212
<211>   404
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 205

<400>   212
Met Arg Ser Ser His Thr Asp Gly Leu Pro Val Ser Leu Asp His Leu 
                5                   10                  15      

Arg Arg Met Thr Asp Asp Thr Gly Leu Ile Glu His Ala Ile Gly Arg 
            20                  25                  30          

Ile Pro Arg Arg Gln Glu Gly Tyr Ser Thr Asp Asp Asn Ala Arg Ala 
        35                  40                  45              

Leu Trp Leu Ala Tyr Glu Trp Leu His Tyr Ala Arg Glu Arg Gly Leu 
    50                  55                  60                  

Glu Ala Glu Ala Ala Asp Leu Ala Arg Leu Ile Asp Ile Tyr Phe Ala 
65                  70                  75                  80  

Phe Leu Ala Trp Val Gln Lys Pro Asp Gly Trp Phe His Asn Asn Val 
                85                  90                  95      

Ser Tyr Asp Arg Arg Phe Glu Leu Glu Val Pro Ser Asp Asp Cys Gln 
            100                 105                 110         

Gly Arg Ser Val Tyr Ala Leu Ala Val Gly Met Cys Glu Glu Arg Asp 
        115                 120                 125             

Pro Ala Arg Leu Thr Ala Tyr Ala Gln Val Leu Arg Arg Gly Leu Glu 
    130                 135                 140                 

Ala Ala Leu Arg Leu Thr His Ala Arg Gly Val Ala His Val Val Ala 
145                 150                 155                 160 

Ala Ala Ala Arg Leu Leu Arg His Ala Glu Gly Val Glu Leu Pro Glu 
                165                 170                 175     

Asp Ala Ala Pro Glu Phe Trp Ala Phe Val Arg Gln Arg Leu Pro Gly 
            180                 185                 190         

Val Val Glu Arg Gly Ala Arg Asp Leu Val Ser Arg Phe Glu Ala His 
        195                 200                 205             

Ala Arg Gly Asp Trp Pro Trp Phe Glu Asp Arg Met Thr Tyr Asp Asn 
    210                 215                 220                 

Ala Val Met Pro Trp Ala Leu Phe Glu Ala Tyr Ala Leu Thr Gly Glu 
225                 230                 235                 240 

Ala Arg Trp Arg Glu Val Ala Glu Ala Ser Leu Asp Gly Leu Leu Ala 
                245                 250                 255     

Arg Met Arg Ala Pro Glu Gly Trp Leu Arg Pro Ile Gly Asn Arg Gly 
            260                 265                 270         

Phe Ala Ala Pro Gly Phe Thr Ala Ile Trp Asp Gln Gln Pro Leu Glu 
        275                 280                 285             

Ile Ala Gln Leu Ala Ile Ala Cys Glu Ser Ala Trp Arg Ala Thr Gly 
    290                 295                 300                 

Asp Thr Ala Tyr Arg Arg Leu Thr Ala Glu Cys Gln Arg Trp Phe Tyr 
305                 310                 315                 320 

Gly Glu Asn Asp Lys Gly Val Pro Met Ala Asp Pro Ala Asp Gly Ser 
                325                 330                 335     

Cys Cys Asp Gly Leu Thr Pro Gln Gly Pro Asn Leu Asn Arg Gly Ala 
            340                 345                 350         

Glu Ser Thr Trp Ser Tyr Leu Ile Thr Glu Ile His Val Glu Arg Ala 
        355                 360                 365             

Phe Ala Glu Asp Leu Asp Ala Ala Arg Ala Phe Gly Ala Trp Val Gly 
    370                 375                 380                 

Val Pro Arg Gln Thr Leu Val Ser Ala Arg Ser Arg Arg Ala Leu Gly 
385                 390                 395                 400 

Gly Phe His Arg 
                

<210>   213
<211>   404
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 205

<400>   213
Met Arg Ser Ser His Thr Asp Gly Leu Pro Val Ser Leu Asp His Leu 
                5                   10                  15      

Arg Arg Met Thr Asp Asp Thr Gly Leu Ile Glu His Ala Ile Gly Arg 
            20                  25                  30          

Ile Pro Arg Arg Gln Glu Gly Tyr Ser Thr Asp Asp Asn Ala Arg Ala 
        35                  40                  45              

Leu Trp Leu Ala Tyr Glu Trp Leu His Tyr Ala Arg Glu Arg Gly Leu 
    50                  55                  60                  

Glu Ala Glu Ala Ala Asp Leu Ala Arg Leu Ile Asp Ile Tyr Phe Ala 
65                  70                  75                  80  

Phe Leu Ala Trp Val Gln Lys Pro Asp Gly Trp Phe His Asn Asn Val 
                85                  90                  95      

Ser Tyr Asp Arg Arg Phe Glu Leu Glu Val Pro Ser Asp Asp Cys Gln 
            100                 105                 110         

Gly Arg Ser Val Tyr Ala Leu Ala Val Gly Met Cys Glu Glu Arg Asp 
        115                 120                 125             

Pro Ala Arg Leu Thr Ala Tyr Ala Gln Val Leu Arg Arg Gly Leu Glu 
    130                 135                 140                 

Ala Ala Leu Arg Leu Thr His Ala Arg Gly Val Ala His Val Val Ala 
145                 150                 155                 160 

Ala Ala Ala Arg Leu Leu Arg His Ala Glu Gly Val Glu Leu Pro Glu 
                165                 170                 175     

Asp Ala Ala Pro Glu Phe Trp Ala Phe Val Arg Gln Arg Leu Pro Gly 
            180                 185                 190         

Val Val Glu Arg Gly Ala Arg Asp Leu Val Ser Arg Phe Glu Ala His 
        195                 200                 205             

Ala Arg Gly Asp Trp Pro Trp Phe Glu Asp Arg Met Thr Tyr Asp Asn 
    210                 215                 220                 

Ala Val Met Pro Trp Ala Leu Phe Glu Ala Tyr Ala Leu Thr Gly Glu 
225                 230                 235                 240 

Ala Arg Trp Arg Glu Val Ala Glu Ala Ser Leu Asp Gly Leu Leu Ala 
                245                 250                 255     

Arg Met Arg Ala Pro Glu Gly Trp Leu Arg Pro Ile Gly Asn Arg Gly 
            260                 265                 270         

Phe Ala Ala Pro Gly Phe Thr Ala Ile Trp Asp Gln Gln Pro Leu Glu 
        275                 280                 285             

Ile Ala Gln Leu Ala Ile Ala Cys Glu Ser Ala Trp Arg Ala Thr Gly 
    290                 295                 300                 

Asp Thr Ala Tyr Arg Arg Leu Thr Ala Glu Cys Gln Arg Trp Phe Tyr 
305                 310                 315                 320 

Gly Glu Asn Asp Lys Gly Val Pro Met Ala Asp Pro Ala Asp Gly Ser 
                325                 330                 335     

Cys Cys Asp Gly Leu Thr Pro Gln Gly Pro Asn Leu Asn Arg Gly Ala 
            340                 345                 350         

Glu Ser Thr Trp Ser Tyr Leu Ile Thr Glu Ile His Val Glu Arg Ala 
        355                 360                 365             

Phe Ala Asp Asp Ile Asp Ala Ala Arg Ala Phe Gly Ala Trp Val Gly 
    370                 375                 380                 

Val Pro Arg Gln Thr Leu Val Ser Ala Arg Ser Arg Arg Ala Leu Gly 
385                 390                 395                 400 

Gly Phe His Arg 
                

<210>   214
<211>   404
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 205

<400>   214
Met Arg Ser Ser His Thr Asp Gly Leu Pro Val Ser Leu Asp His Leu 
                5                   10                  15      

Arg Arg Met Thr Asp Asp Thr Gly Leu Ile Glu His Ala Ile Gly Arg 
            20                  25                  30          

Ile Pro Arg Arg Gln Glu Gly Tyr Ser Thr Asp Asp Asn Ala Arg Ala 
        35                  40                  45              

Leu Trp Leu Ala Tyr Glu Trp Leu His Tyr Ala Arg Glu Arg Gly Leu 
    50                  55                  60                  

Glu Ala Glu Ala Ala Asp Leu Ala Arg Leu Ile Asp Ile Tyr Phe Ala 
65                  70                  75                  80  

Phe Leu Ala Trp Val Gln Lys Pro Asp Gly Trp Phe His Asn Asn Val 
                85                  90                  95      

Ser Tyr Asp Arg Arg Phe Glu Leu Glu Val Pro Ser Asp Asp Cys Gln 
            100                 105                 110         

Gly Arg Ser Val Tyr Ala Leu Ala Val Gly Met Cys Glu Glu Arg Asp 
        115                 120                 125             

Pro Ala Arg Leu Thr Ala Tyr Ala Gln Val Leu Arg Arg Gly Leu Glu 
    130                 135                 140                 

Ala Ala Leu Arg Leu Thr His Ala Arg Gly Val Ala His Val Val Ala 
145                 150                 155                 160 

Ala Ala Ala Arg Leu Leu Arg His Ala Glu Gly Val Glu Leu Pro Glu 
                165                 170                 175     

Asp Ala Ala Pro Glu Phe Trp Ala Phe Val Arg Gln Arg Leu Pro Gly 
            180                 185                 190         

Val Val Glu Arg Gly Ala Arg Asp Leu Val Ser Arg Phe Glu Ala His 
        195                 200                 205             

Ala Arg Gly Asp Trp Pro Trp Phe Glu Asp Arg Met Thr Tyr Asp Asn 
    210                 215                 220                 

Ala Val Met Pro Trp Ala Leu Phe Glu Ala Tyr Ala Leu Thr Gly Glu 
225                 230                 235                 240 

Ala Arg Trp Arg Glu Val Ala Glu Ala Ser Leu Asp Gly Leu Leu Ala 
                245                 250                 255     

Arg Met Lys Ala Pro Glu Gly Trp Leu Arg Pro Ile Gly Asn Arg Gly 
            260                 265                 270         

Phe Ala Ala Pro Gly Phe Thr Ala Ile Trp Asp Gln Gln Pro Leu Glu 
        275                 280                 285             

Ile Ala Gln Leu Ala Ile Ala Cys Glu Ser Ala Trp Arg Ala Thr Gly 
    290                 295                 300                 

Asp Thr Ala Tyr Arg Arg Leu Thr Ala Glu Cys Gln Arg Trp Phe Tyr 
305                 310                 315                 320 

Gly Glu Asn Asp Lys Gly Val Pro Met Ala Asp Pro Ala Asp Gly Ser 
                325                 330                 335     

Cys Cys Asp Gly Leu Thr Pro Gln Gly Pro Asn Leu Asn Arg Gly Ala 
            340                 345                 350         

Glu Ser Thr Trp Ser Tyr Leu Ile Thr Glu Ile His Val Glu Arg Ala 
        355                 360                 365             

Phe Ala Asp Asp Leu Asp Ala Ala Arg Ala Phe Gly Ala Trp Val Gly 
    370                 375                 380                 

Val Pro Arg Gln Thr Leu Val Ser Ala Arg Ser Arg Arg Ala Leu Gly 
385                 390                 395                 400 

Gly Phe His Arg 
                

<210>   215
<211>   404
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 205

<400>   215
Met Arg Ser Ser His Thr Asp Gly Leu Pro Val Ser Leu Asp His Leu 
                5                   10                  15      

Arg Arg Met Thr Asp Asp Thr Gly Leu Ile Glu His Ala Ile Gly Arg 
            20                  25                  30          

Ile Pro Arg Arg Gln Glu Gly Tyr Ser Thr Asp Asp Asn Ala Arg Ala 
        35                  40                  45              

Leu Trp Leu Ala Tyr Glu Trp Leu His Tyr Ala Arg Glu Arg Gly Leu 
    50                  55                  60                  

Glu Ala Glu Ala Ala Asp Leu Ala Arg Leu Ile Asp Ile Tyr Phe Ala 
65                  70                  75                  80  

Phe Leu Ala Trp Val Gln Lys Pro Asp Gly Trp Phe His Asn Asn Val 
                85                  90                  95      

Ser Tyr Asp Arg Arg Phe Glu Leu Glu Val Pro Ser Asp Asp Cys Gln 
            100                 105                 110         

Gly Arg Ser Val Tyr Ala Leu Ala Val Gly Met Cys Glu Glu Arg Asp 
        115                 120                 125             

Pro Ala Arg Leu Thr Ala Tyr Ala Gln Val Leu Arg Arg Gly Leu Glu 
    130                 135                 140                 

Ala Ala Leu Arg Leu Thr His Ala Arg Gly Val Ala His Val Val Ala 
145                 150                 155                 160 

Ala Ala Ala Arg Leu Leu Arg His Ala Glu Gly Val Glu Leu Pro Glu 
                165                 170                 175     

Asp Ala Ala Pro Glu Phe Trp Ala Phe Val Arg Gln Arg Leu Pro Gly 
            180                 185                 190         

Val Val Glu Arg Gly Ala Arg Asp Leu Val Ser Arg Phe Glu Ala His 
        195                 200                 205             

Ala Arg Gly Asp Trp Pro Trp Phe Glu Asp Arg Met Thr Tyr Glu Asn 
    210                 215                 220                 

Ala Val Met Pro Trp Ala Leu Phe Glu Ala Tyr Ala Leu Thr Gly Glu 
225                 230                 235                 240 

Ala Arg Trp Arg Glu Val Ala Glu Ala Ser Leu Asp Gly Leu Leu Ala 
                245                 250                 255     

Arg Met Arg Ala Pro Glu Gly Trp Leu Arg Pro Ile Gly Asn Arg Gly 
            260                 265                 270         

Phe Ala Ala Pro Gly Phe Thr Ala Ile Trp Asp Gln Gln Pro Leu Glu 
        275                 280                 285             

Ile Ala Gln Leu Ala Ile Ala Cys Glu Ser Ala Trp Arg Ala Thr Gly 
    290                 295                 300                 

Asp Thr Ala Tyr Arg Arg Leu Thr Ala Glu Cys Gln Arg Trp Phe Tyr 
305                 310                 315                 320 

Gly Glu Asn Asp Lys Gly Val Pro Met Ala Asp Pro Ala Asp Gly Ser 
                325                 330                 335     

Cys Cys Asp Gly Leu Thr Pro Gln Gly Pro Asn Leu Asn Arg Gly Ala 
            340                 345                 350         

Glu Ser Thr Trp Ser Tyr Leu Ile Thr Glu Ile His Val Glu Arg Ala 
        355                 360                 365             

Phe Ala Asp Asp Leu Asp Ala Ala Arg Ala Phe Gly Ala Trp Val Gly 
    370                 375                 380                 

Val Pro Arg Gln Thr Leu Val Ser Ala Arg Ser Arg Arg Ala Leu Gly 
385                 390                 395                 400 

Gly Phe His Arg 
                

<210>   216
<211>   404
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 205

<400>   216
Met Arg Ser Ser His Thr Asp Gly Leu Pro Val Ser Leu Asp His Leu 
                5                   10                  15      

Arg Arg Met Thr Asp Asp Thr Gly Leu Ile Glu His Ala Ile Gly Arg 
            20                  25                  30          

Ile Pro Arg Arg Gln Glu Gly Tyr Ser Thr Asp Asp Asn Ala Arg Ala 
        35                  40                  45              

Leu Trp Leu Ala Tyr Glu Trp Leu His Tyr Ala Arg Glu Arg Gly Leu 
    50                  55                  60                  

Glu Ala Glu Ala Ala Asp Leu Ala Arg Leu Ile Asp Ile Tyr Phe Ala 
65                  70                  75                  80  

Phe Leu Ala Trp Val Gln Lys Pro Asp Gly Trp Phe His Asn Asn Val 
                85                  90                  95      

Ser Tyr Asp Arg Arg Phe Glu Leu Glu Val Pro Ser Asp Asp Cys Gln 
            100                 105                 110         

Gly Arg Ser Val Tyr Ala Leu Ala Val Gly Met Cys Glu Glu Arg Asp 
        115                 120                 125             

Pro Ala Arg Leu Thr Ala Tyr Ala Gln Val Leu Arg Arg Gly Leu Asp 
    130                 135                 140                 

Ala Ala Leu Arg Leu Thr His Ala Arg Gly Val Ala His Val Val Ala 
145                 150                 155                 160 

Ala Ala Ala Arg Leu Leu Arg His Ala Glu Gly Val Glu Leu Pro Glu 
                165                 170                 175     

Asp Ala Ala Pro Glu Phe Trp Ala Phe Val Arg Gln Arg Leu Pro Gly 
            180                 185                 190         

Val Val Glu Arg Gly Ala Arg Asp Leu Val Ser Arg Phe Glu Ala His 
        195                 200                 205             

Ala Arg Gly Asp Trp Pro Trp Phe Glu Asp Arg Met Thr Tyr Asp Asn 
    210                 215                 220                 

Ala Val Met Pro Trp Ala Leu Phe Glu Ala Tyr Ala Leu Thr Gly Glu 
225                 230                 235                 240 

Ala Arg Trp Arg Glu Val Ala Glu Ala Ser Leu Asp Gly Leu Leu Ala 
                245                 250                 255     

Arg Met Arg Ala Pro Glu Gly Trp Leu Arg Pro Ile Gly Asn Arg Gly 
            260                 265                 270         

Phe Ala Ala Pro Gly Phe Thr Ala Ile Trp Asp Gln Gln Pro Leu Glu 
        275                 280                 285             

Ile Ala Gln Leu Ala Ile Ala Cys Glu Ser Ala Trp Arg Ala Thr Gly 
    290                 295                 300                 

Asp Thr Ala Tyr Arg Arg Leu Thr Ala Glu Cys Gln Arg Trp Phe Tyr 
305                 310                 315                 320 

Gly Glu Asn Asp Lys Gly Val Pro Met Ala Asp Pro Ala Asp Gly Ser 
                325                 330                 335     

Cys Cys Asp Gly Leu Thr Pro Gln Gly Pro Asn Leu Asn Arg Gly Ala 
            340                 345                 350         

Glu Ser Thr Trp Ser Tyr Leu Ile Thr Glu Ile His Val Glu Arg Ala 
        355                 360                 365             

Phe Ala Asp Asp Leu Asp Ala Ala Arg Ala Phe Gly Ala Trp Val Gly 
    370                 375                 380                 

Val Pro Arg Gln Thr Leu Val Ser Ala Arg Ser Arg Arg Ala Leu Gly 
385                 390                 395                 400 

Gly Phe His Arg 
                

<210>   217
<211>   1215
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 206

<400>   217
ttgcggtcat cgcacactga tgggctgccg gtttcgctgg atcacctgcg ccggatgaca       60

gacgacacag ggctcattga acacgcgatt ggccgcattc ctcgccgtca ggaagggtat      120

tccaccgacg acaacgcgcg ggcgctctgg ctcgcgtacg agtggctcca ctacgcccgc      180

gagcggggcc tggaggcgga ggcggccgat ctcgcgcggc tcatcgacat ctacttcgcg      240

tttttggcct gggtccagaa gcccgacggc tggttccaca acaacgtgtc gtacgatcgc      300

cgctttgagc tggaggttcc gtcggacgac tgccaaggga ggtccgtgta cgcgctggcg      360

gtgggcatgt gcgaggagcg cgatccggcc cgcctgacgg cctacgcgca agtgcttcgc      420

cggggccttg aggcagccct taggctcacg cacgcacgcg gcgtcgccca tgtcgtagcg      480

gccgccgcaa ggcttttgcg ccacgcagag ggggtcgagc ttcccgaaga cgcggcgccc      540

gagttctggg cctttgtccg tcagcgcctg ccgggcgtcg tggagcgcgg cgctcgcgat      600

ctcgtgtcgc ggttcgaggc gcacgcacgc ggcgactggc cttggttcga ggaccgcatg      660

acgtacgaca acgcggtcat gccctgggcg ctcttcgaag cctatgcgct caccggcgag      720

gcccgatgga gagaagtcgc ggaagcctcg ctcgacgggc ttctcgcccg catgcgtgcg      780

cccgagggat ggcttcggcc cattggcaac cgcggcttcg cggcgcctgg cttcaccgcc      840

atttgggacc agcagccgct ggaaatcgcc cagctcgcca ttgcgtgcga atcggcctgg      900

cgcgcgacgg gtgacacggc ctatcggcgg cttacggccg agtgccagcg ctggttctac      960

ggtgaaaacg acaaaggggt gccgatggcc gatccggccg acggcagttg ctgcgacggc     1020

ctgacgccgc agggtcccaa cctgaaccgc ggtgcagagt cgacgtggtc gtacctcatc     1080

accgagatcc acgtcgagcg ggcatttgcc gaagatctgg acgccgcgcg ggcgttcggc     1140

gcgtgggtgg gcgttccgcg ccagaccctc gtgtccgcac ggtcgagacg ggcgctcggc     1200

ggctttcacc ggtga                                                      1215


<210>   218
<211>   1215
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 206

<400>   218
ttgcggtcat cgcacactga tgggctgccg gtttcgctgg atcacctgcg ccggatgaca       60

gacgacacag ggctcattga acacgcgatt ggccgcattc ctcgccgtca ggaagggtat      120

tccaccgacg acaacgcgcg ggcgctctgg ctcgcgtacg agtggctcca ctacgcccgc      180

gagcggggcc tggaggcgga ggcggccgat ctcgcgcggc tcatcgacat ctacttcgcg      240

tttttggcct gggtccagaa gcccgacggc tggttccaca acaacgtgtc gtacgatcgc      300

cgctttgagc tggaggttcc gtcggacgac tgccaaggga ggtccgtgta cgcgctggcg      360

gtgggcatgt gcgaggagcg cgatccggcc cgcctgacgg cctacgcgca agtgcttcgc      420

cggggccttg aggcagccct taggctcacg cacgcacgcg gcgtcgccca tgtcgtagcg      480

gccgccgcaa ggcttttgcg ccacgcagag ggggtcgagc ttcccgaaga cgcggcgccc      540

gagttctggg cctttgtccg tcagcgcctg ccgggcgtcg tggagcgcgg cgctcgcgat      600

ctcgtgtcgc ggttcgaggc gcacgcacgc ggcgactggc cttggttcga ggaccgcatg      660

acgtacgaca acgcggtcat gccctgggcg ctcttcgaag cctatgcgct caccggcgag      720

gcccgatgga gagaagtcgc ggaagcctcg ctcgacgggc ttctcgcccg catgcgtgcg      780

cccgagggat ggcttcggcc cattggcaac cgcggcttcg cggcgcctgg cttcaccgcc      840

atttgggacc agcagccgct ggaaatcgcc cagctcgcca ttgcgtgcga atcggcctgg      900

cgcgcgacgg gtgacacggc ctatcggcgg cttacggccg agtgccagcg ctggttctac      960

ggtgaaaacg acaaaggggt gccgatggcc gatccggccg acggcagttg ctgcgacggc     1020

ctgacgccgc agggtcccaa cctgaaccgc ggtgcagagt cgacgtggtc gtacctcatc     1080

accgagatcc acgtcgagcg ggcatttgcc gatgatattg acgccgcgcg ggcgttcggc     1140

gcgtgggtgg gcgttccgcg ccagaccctc gtgtccgcac ggtcgagacg ggcgctcggc     1200

ggctttcacc ggtga                                                      1215


<210>   219
<211>   1215
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 206

<400>   219
ttgcggtcat cgcacactga tgggctgccg gtttcgctgg atcacctgcg ccggatgaca       60

gacgacacag ggctcattga acacgcgatt ggccgcattc ctcgccgtca ggaagggtat      120

tccaccgacg acaacgcgcg ggcgctctgg ctcgcgtacg agtggctcca ctacgcccgc      180

gagcggggcc tggaggcgga ggcggccgat ctcgcgcggc tcatcgacat ctacttcgcg      240

tttttggcct gggtccagaa gcccgacggc tggttccaca acaacgtgtc gtacgatcgc      300

cgctttgagc tggaggttcc gtcggacgac tgccaaggga ggtccgtgta cgcgctggcg      360

gtgggcatgt gcgaggagcg cgatccggcc cgcctgacgg cctacgcgca agtgcttcgc      420

cggggccttg aggcagccct taggctcacg cacgcacgcg gcgtcgccca tgtcgtagcg      480

gccgccgcaa ggcttttgcg ccacgcagag ggggtcgagc ttcccgaaga cgcggcgccc      540

gagttctggg cctttgtccg tcagcgcctg ccgggcgtcg tggagcgcgg cgctcgcgat      600

ctcgtgtcgc ggttcgaggc gcacgcacgc ggcgactggc cttggttcga ggaccgcatg      660

acgtacgaca acgcggtcat gccctgggcg ctcttcgaag cctatgcgct caccggcgag      720

gcccgatgga gagaagtcgc ggaagcctcg ctcgacgggc ttctcgcccg catgaaagcg      780

cccgagggat ggcttcggcc cattggcaac cgcggcttcg cggcgcctgg cttcaccgcc      840

atttgggacc agcagccgct ggaaatcgcc cagctcgcca ttgcgtgcga atcggcctgg      900

cgcgcgacgg gtgacacggc ctatcggcgg cttacggccg agtgccagcg ctggttctac      960

ggtgaaaacg acaaaggggt gccgatggcc gatccggccg acggcagttg ctgcgacggc     1020

ctgacgccgc agggtcccaa cctgaaccgc ggtgcagagt cgacgtggtc gtacctcatc     1080

accgagatcc acgtcgagcg ggcatttgcc gatgatctgg acgccgcgcg ggcgttcggc     1140

gcgtgggtgg gcgttccgcg ccagaccctc gtgtccgcac ggtcgagacg ggcgctcggc     1200

ggctttcacc ggtga                                                      1215


<210>   220
<211>   1215
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 206

<400>   220
ttgcggtcat cgcacactga tgggctgccg gtttcgctgg atcacctgcg ccggatgaca       60

gacgacacag ggctcattga acacgcgatt ggccgcattc ctcgccgtca ggaagggtat      120

tccaccgacg acaacgcgcg ggcgctctgg ctcgcgtacg agtggctcca ctacgcccgc      180

gagcggggcc tggaggcgga ggcggccgat ctcgcgcggc tcatcgacat ctacttcgcg      240

tttttggcct gggtccagaa gcccgacggc tggttccaca acaacgtgtc gtacgatcgc      300

cgctttgagc tggaggttcc gtcggacgac tgccaaggga ggtccgtgta cgcgctggcg      360

gtgggcatgt gcgaggagcg cgatccggcc cgcctgacgg cctacgcgca agtgcttcgc      420

cggggccttg aggcagccct taggctcacg cacgcacgcg gcgtcgccca tgtcgtagcg      480

gccgccgcaa ggcttttgcg ccacgcagag ggggtcgagc ttcccgaaga cgcggcgccc      540

gagttctggg cctttgtccg tcagcgcctg ccgggcgtcg tggagcgcgg cgctcgcgat      600

ctcgtgtcgc ggttcgaggc gcacgcacgc ggcgactggc cttggttcga ggaccgcatg      660

acgtacgaaa acgcggtcat gccctgggcg ctcttcgaag cctatgcgct caccggcgag      720

gcccgatgga gagaagtcgc ggaagcctcg ctcgacgggc ttctcgcccg catgcgtgcg      780

cccgagggat ggcttcggcc cattggcaac cgcggcttcg cggcgcctgg cttcaccgcc      840

atttgggacc agcagccgct ggaaatcgcc cagctcgcca ttgcgtgcga atcggcctgg      900

cgcgcgacgg gtgacacggc ctatcggcgg cttacggccg agtgccagcg ctggttctac      960

ggtgaaaacg acaaaggggt gccgatggcc gatccggccg acggcagttg ctgcgacggc     1020

ctgacgccgc agggtcccaa cctgaaccgc ggtgcagagt cgacgtggtc gtacctcatc     1080

accgagatcc acgtcgagcg ggcatttgcc gatgatctgg acgccgcgcg ggcgttcggc     1140

gcgtgggtgg gcgttccgcg ccagaccctc gtgtccgcac ggtcgagacg ggcgctcggc     1200

ggctttcacc ggtga                                                      1215


<210>   221
<211>   1215
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 206

<400>   221
ttgcggtcat cgcacactga tgggctgccg gtttcgctgg atcacctgcg ccggatgaca       60

gacgacacag ggctcattga acacgcgatt ggccgcattc ctcgccgtca ggaagggtat      120

tccaccgacg acaacgcgcg ggcgctctgg ctcgcgtacg agtggctcca ctacgcccgc      180

gagcggggcc tggaggcgga ggcggccgat ctcgcgcggc tcatcgacat ctacttcgcg      240

tttttggcct gggtccagaa gcccgacggc tggttccaca acaacgtgtc gtacgatcgc      300

cgctttgagc tggaggttcc gtcggacgac tgccaaggga ggtccgtgta cgcgctggcg      360

gtgggcatgt gcgaggagcg cgatccggcc cgcctgacgg cctacgcgca agtgcttcgc      420

cggggccttg atgcagccct taggctcacg cacgcacgcg gcgtcgccca tgtcgtagcg      480

gccgccgcaa ggcttttgcg ccacgcagag ggggtcgagc ttcccgaaga cgcggcgccc      540

gagttctggg cctttgtccg tcagcgcctg ccgggcgtcg tggagcgcgg cgctcgcgat      600

ctcgtgtcgc ggttcgaggc gcacgcacgc ggcgactggc cttggttcga ggaccgcatg      660

acgtacgaca acgcggtcat gccctgggcg ctcttcgaag cctatgcgct caccggcgag      720

gcccgatgga gagaagtcgc ggaagcctcg ctcgacgggc ttctcgcccg catgcgtgcg      780

cccgagggat ggcttcggcc cattggcaac cgcggcttcg cggcgcctgg cttcaccgcc      840

atttgggacc agcagccgct ggaaatcgcc cagctcgcca ttgcgtgcga atcggcctgg      900

cgcgcgacgg gtgacacggc ctatcggcgg cttacggccg agtgccagcg ctggttctac      960

ggtgaaaacg acaaaggggt gccgatggcc gatccggccg acggcagttg ctgcgacggc     1020

ctgacgccgc agggtcccaa cctgaaccgc ggtgcagagt cgacgtggtc gtacctcatc     1080

accgagatcc acgtcgagcg ggcatttgcc gatgatctgg acgccgcgcg ggcgttcggc     1140

gcgtgggtgg gcgttccgcg ccagaccctc gtgtccgcac ggtcgagacg ggcgctcggc     1200

ggctttcacc ggtga                                                      1215


<210>   222
<211>   417
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   222
Met Thr Leu Met Tyr Leu Leu Trp Asp Thr Phe Tyr Asp Ala Leu Lys 
                5                   10                  15      

Leu Val Thr Gly Leu Val Ala Leu Tyr Gln Ile Val Leu Ser Val Tyr 
            20                  25                  30          

Gly Ile Trp His Arg Arg Arg Pro Ile Thr His Ala Pro Gln Lys Arg 
        35                  40                  45              

Phe Ala Ile Ile Ile Pro Ala His Asn Glu Glu Cys Val Ile Gly Pro 
    50                  55                  60                  

Leu Leu Asp Ser Leu Lys Arg Gln Thr Tyr Pro Ala His Leu Tyr Asp 
65                  70                  75                  80  

Val His Val Ile Ala Asp Asn Cys Thr Asp Gly Thr Ala Glu Arg Ala 
                85                  90                  95      

Arg Ala His Gly Ala Ile Val His Val Arg Glu Asn Arg Ala Glu Gln 
            100                 105                 110         

Gly Lys Gly Tyr Ala Ile Glu Trp Met Leu Ala Arg Leu Lys Glu Met 
        115                 120                 125             

Gly Ala Arg Tyr Asp Ala Ile Val Met Phe Asp Ala Asp Asn Leu Val 
    130                 135                 140                 

His Pro Asp Phe Leu Ala Ile Met Asn Asp His Leu Cys Ser Gly Asp 
145                 150                 155                 160 

Arg Val Ile Gln Gly Tyr Leu Asp Thr Lys Asn Pro Phe Asp Ser Trp 
                165                 170                 175     

Ile Ser Val Ser Leu Ala Ile Ser Tyr Trp Phe Asp Asn Arg Leu Trp 
            180                 185                 190         

Gln Tyr Ala Arg Ala Arg Leu His Leu Pro Cys Thr Leu Gly Gly Thr 
        195                 200                 205             

Gly Leu Cys Ile Asp Tyr Pro Leu Leu Gln Glu Met Gly Trp Lys Ala 
    210                 215                 220                 

Thr Gly Leu Thr Glu Asp Leu Glu Phe Gly Ile Arg Cys Val Arg Arg 
225                 230                 235                 240 

Gly Ile Ile Pro Val Trp Ala His Asp Ala Arg Val Tyr Asp Glu Lys 
                245                 250                 255     

Pro Thr Ser Phe Ala Ala Ser Phe Arg Gln Arg Leu Arg Trp Gln Gln 
            260                 265                 270         

Gly His Phe Gln Cys Ala Arg Glu His Leu Val Pro Met Phe Leu Glu 
        275                 280                 285             

Gly Leu Arg Glu Arg Asn Leu Ala Lys Ile Asp Met Ala Ile Tyr Leu 
    290                 295                 300                 

Phe Gln Pro Met Arg Ser Met Leu Leu Phe Ala Gly Ala Met Ile Val 
305                 310                 315                 320 

Leu Gly Leu His Tyr Leu Ser Pro Asp Pro Thr Asp Ala Ala Ser Asn 
                325                 330                 335     

Pro Ala Ala Leu Met Val Thr Asn Leu Trp Val Ala Val Asn Val Ile 
            340                 345                 350         

Leu Phe Leu Glu Val Pro Leu Ala Leu Leu Leu Glu Arg Val Asn Trp 
        355                 360                 365             

Arg Ala Tyr Phe Ala Leu Pro Leu Leu Pro Phe Phe Leu Trp Thr Trp 
    370                 375                 380                 

Gly Pro Val Thr Leu Gln Ala Tyr Phe Thr Arg Ser Asn Arg Thr Trp 
385                 390                 395                 400 

Tyr His Thr Val His Lys Arg Ala Ile Arg Leu Asp Glu Leu Arg Glu 
                405                 410                 415     

Arg 
    

<210>   223
<211>   1254
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   223
atgacattga tgtacttgct ctgggacacg ttctatgacg cgctgaagct cgtcacgggc       60

cttgtggcgc tgtaccagat tgtgctgtcc gtgtacggca tctggcaccg cagacggccc      120

atcacgcatg cgccgcagaa gcgcttcgcc atcatcattc cggcgcacaa cgaggagtgc      180

gtgatcggcc cgctcctcga cagcctgaag cgccagacgt atcccgcgca cctgtacgac      240

gtgcatgtca tcgcggacaa ctgcacggac ggcaccgcgg agcgcgcgcg ggcgcacggc      300

gccattgtcc acgtgcgcga aaaccgcgcg gaacagggca aggggtacgc catcgaatgg      360

atgctggcgc gcctgaagga aatgggcgct cgatacgacg ccatcgtgat gttcgacgcg      420

gataatttgg ttcatccgga ctttctcgcc atcatgaacg accacctgtg cagcggcgat      480

cgcgtcattc agggatatct ggataccaag aatccattcg attcgtggat cagcgtgtcg      540

ctcgccatct cctattggtt cgacaatcgg ctgtggcagt acgcccgcgc ccgcctgcat      600

ctgccgtgta cgctcggtgg gaccggcctt tgcatcgatt atccgctgtt gcaggagatg      660

ggatggaagg cgacgggcct caccgaggat ctcgagttcg ggattcgctg cgtccgccga      720

ggaattatcc ccgtctgggc gcacgacgcg cgcgtctacg acgagaagcc gacgagcttc      780

gcggcgtctt tccgccagcg cctgcgctgg cagcaggggc atttccaatg tgcacgtgaa      840

cacttggtcc ccatgtttct cgaggggctg cgcgagcgga acttggccaa aatcgacatg      900

gccatttacc tgtttcagcc catgcggtcc atgctgctgt ttgcgggcgc catgattgtg      960

ctcggccttc actacctgtc gcccgatccg accgatgcag cgtccaaccc ggccgcgctc     1020

atggtcacga atctgtgggt cgcggtgaac gtgatcctgt ttctcgaggt tcccctcgcg     1080

ctgctgctcg aacgggtgaa ctggcgggcg tattttgccc tgcccctcct tccgttcttt     1140

ctctggacct ggggccccgt gacgctgcag gcctacttca cgcgcagcaa ccggacgtgg     1200

taccacacgg tgcacaagcg cgccattcgc ttggatgagc tgcgcgagcg gtaa           1254


<210>   224
<211>   402
<212>   PRT
<213>   Clostridium thermocellum ATCC 27405

<400>   224
Met Gln Val Val Ile Phe Ile Ala Gly Cys Tyr Phe Phe Gly Ile Ser 
                5                   10                  15      

Ile Phe Gly Trp Ile Lys Arg Arg Glu Thr Ser Pro Lys Glu Tyr Val 
            20                  25                  30          

Pro Gln Lys Lys Phe Ala Leu Ile Val Ala Ala His Asn Glu Glu Ala 
        35                  40                  45              

Val Ile Gly His Ile Val Asp Ser Leu Phe Arg Gln Asn Tyr Pro Arg 
    50                  55                  60                  

Asn Leu Phe Asp Val Tyr Val Val Ala Asp Asn Cys Thr Asp Arg Thr 
65                  70                  75                  80  

Ala Glu Ile Ala Glu Glu His Gly Ala Ile Val Tyr Lys Arg Tyr Asn 
                85                  90                  95      

Asn Ser Ala Arg Gly Lys Gly Tyr Ala Leu Glu Trp Met Phe Glu Lys 
            100                 105                 110         

Ile Tyr Asn Met Glu Glu Lys Tyr Asp Ala Ile Ser Val Phe Asp Ala 
        115                 120                 125             

Asp Asn Leu Val Ser Ala Asn Tyr Leu Leu Glu Met Asn Lys Gln Leu 
    130                 135                 140                 

Cys Lys Gly His Lys Val Val Gln Gly Tyr Val Asp Ser Lys Asn Pro 
145                 150                 155                 160 

Phe Asp Ser Trp Ile Thr Leu Ser Tyr Ser Ile Ala Phe Trp Leu Ser 
                165                 170                 175     

Asn Arg Ile Phe Gln Leu Pro Arg Tyr Tyr Leu Gly Leu Ser Cys Gly 
            180                 185                 190         

Leu Cys Gly Thr Gly Phe Cys Ile Ser Val Asp Val Leu Lys Glu Ile 
        195                 200                 205             

Gly Trp Gly Ala Thr Cys Leu Thr Glu Asp Leu Glu Phe Thr Met Lys 
    210                 215                 220                 

Leu Ala Leu Asn Asn Tyr Lys Val Ala Trp Ala His Asn Ala Val Val 
225                 230                 235                 240 

Tyr Asp Glu Lys Pro Ile Thr Leu Lys Gln Ser Trp Asn Gln Arg Lys 
                245                 250                 255     

Arg Trp Met Gln Gly His Ala Asp Cys Ala Ser Arg Tyr Leu Gly Pro 
            260                 265                 270         

Leu Phe Lys Lys Ala Phe Arg Glu Gly Asp Leu Ile Ala Phe Asp Cys 
        275                 280                 285             

Ala Val Tyr Leu Phe Gln Pro Ile Arg Leu Val Phe Ile Gly Leu Ile 
    290                 295                 300                 

Thr Ile Met Met Trp Ile Gln Thr Val Phe Pro Glu Ser Pro Phe Tyr 
305                 310                 315                 320 

Asn Leu Lys Tyr Val Phe Pro Thr Glu Val Trp Ser Val Phe Val Thr 
                325                 330                 335     

Leu Gln Phe Leu Tyr Gly Pro Leu Val Val Leu Ser Glu Lys Lys Phe 
            340                 345                 350         

Asn Leu Lys Val Leu Tyr Gly Phe Leu Ile Tyr Pro Phe Tyr Cys Ile 
        355                 360                 365             

Thr Trp Ile Pro Ile Thr Ile Gln Gly Phe Met Ser Lys Asn Asn Lys 
    370                 375                 380                 

Asp Trp Ser His Thr Gln His Ser Arg Lys Ile Ser Ile Ser Asp Leu 
385                 390                 395                 400 

Glu Lys 
        

<210>   225
<211>   407
<212>   PRT
<213>   Thermosinus carboxydivorans Nor1

<400>   225
Met Asn Tyr Ile Phe Asp Tyr Ile Met Ile Pro Met Gln Leu Ile Ile 
                5                   10                  15      

Ile Phe Phe Thr Leu Tyr Tyr Phe Ile Ile Ala Ile Phe Gly Ile Trp 
            20                  25                  30          

Arg Arg Lys Glu Glu Lys Ile Thr Thr Pro Glu Lys Ser Phe Ala Ile 
        35                  40                  45              

Ile Ile Ala Ala His Asn Glu Glu Gln Val Ile Gly Gln Leu Val Glu 
    50                  55                  60                  

Asn Leu Gln Val Leu Arg Tyr Pro Arg Glu Leu Tyr Asp Ile Phe Val 
65                  70                  75                  80  

Val Ala Asp Asn Cys Lys Asp Arg Thr Ala Gln Ile Ala Arg Asn Ala 
                85                  90                  95      

Gly Ala Ile Val Tyr Glu Arg Phe Asn Leu Glu Gln Arg Gly Lys Gly 
            100                 105                 110         

Tyr Ala Met Glu Trp Met Phe Ala Lys Leu Phe Arg Met Lys Arg Lys 
        115                 120                 125             

Tyr Asp Ala Val Val Val Phe Asp Ala Asp Asn Leu Val His Pro Asn 
    130                 135                 140                 

Phe Leu Leu Glu Met Asn Asn Arg Leu Cys Lys Gly Glu Lys Val Ile 
145                 150                 155                 160 

Gln Gly Tyr Leu Asp Ala Lys Asn Pro His Asp Thr Trp Ile Ala Gly 
                165                 170                 175     

Thr Phe Ala Ile Ser Phe Trp Val Val Asn His Ile Trp His Leu Ala 
            180                 185                 190         

Lys Tyr Asn Ile Gly Leu Ser Ser Val Leu Gly Gly Thr Gly Met Cys 
        195                 200                 205             

Ile Ala Thr Asp Val Leu Gln Lys Phe Gly Trp Gly Ala Thr Cys Leu 
    210                 215                 220                 

Thr Glu Asp Met Glu Phe Thr Met Lys Val Leu Leu Lys Gly Ile Arg 
225                 230                 235                 240 

Thr Thr Trp Ala His Asp Ala Ile Val Tyr Asp Glu Lys Pro Leu Thr 
                245                 250                 255     

Phe Lys Gln Ser Trp Tyr Gln Arg Lys Arg Trp Ala Gln Gly His Phe 
            260                 265                 270         

Asp Val Ala Gly Arg Tyr Ile Pro Arg Leu Leu Tyr Glu Gly Phe Lys 
        275                 280                 285             

Arg Arg Asp Ile Arg Ile Leu Asp Gly Val Leu His Leu Leu Gln Pro 
    290                 295                 300                 

His Phe Leu Ile Leu Ser Thr Ile Phe Val Leu Leu Ser Tyr Ile Tyr 
305                 310                 315                 320 

His Ile Val Pro Phe Tyr Thr Asn Ile Leu Tyr Met Val Leu Pro Val 
                325                 330                 335     

Glu Val Trp Thr Val Ile Ala Ile Gly Gln Tyr Val Phe Pro Ile Ile 
            340                 345                 350         

Val Leu Ala Lys Ile Arg Ala His Trp Lys Ser Trp Leu Tyr Leu Ile 
        355                 360                 365             

Phe Tyr Pro Ile Phe Val Tyr Ser Trp Ile Pro Ile Thr Phe Met Gly 
    370                 375                 380                 

Tyr Leu His Arg Asn Asp Arg Glu Trp Ser His Thr Gln His Thr Arg 
385                 390                 395                 400 

Gly Leu Ser Tyr His Asp Ile 
                405         

<210>   226
<211>   400
<212>   PRT
<213>   Clostridium cellulolyticum H10

<400>   226
Ile Gln Ile Leu Ile Phe Ile Ala Gly Cys Tyr Phe Phe Gly Ile Ser 
                5                   10                  15      

Ile Phe Gly Trp Val Lys Arg Arg Gln Lys Ser Pro Gln Asn Ile Ile 
            20                  25                  30          

Pro Thr Lys Arg Phe Ala Leu Val Val Ala Ala His Asn Glu Glu Leu 
        35                  40                  45              

Val Ile Gly His Ile Val Asp Ser Leu Phe Lys Leu Asn Tyr Pro Lys 
    50                  55                  60                  

Asn Leu Tyr Asp Val Phe Val Ile Ala Asp Asn Cys Thr Asp Asn Thr 
65                  70                  75                  80  

Ala Gly Ile Ala Arg Arg Phe Gly Ala Lys Val His Ile Arg Glu Asp 
                85                  90                  95      

Ala Ser Lys Lys Gly Lys Gly His Ala Leu Glu Trp Met Phe His Arg 
            100                 105                 110         

Ile Phe His Met Asp Thr Ser Tyr Asp Ala Ile Ala Val Phe Asp Ala 
        115                 120                 125             

Asp Asn Leu Val Ser Gln Asn Phe Leu Leu Glu Met Asn Lys Gln Met 
    130                 135                 140                 

Cys Lys Gly Phe Lys Val Val Gln Gly Tyr Ile Asp Ser Lys Asn Pro 
145                 150                 155                 160 

Tyr Asp Ser Trp Ile Thr Cys Ser Tyr Ser Ile Ala Phe Trp Leu Ser 
                165                 170                 175     

Asn Arg Ile Tyr Gln Leu Pro Arg Tyr Tyr Leu Lys Leu Ser Cys Gly 
            180                 185                 190         

Leu Cys Gly Thr Gly Phe Cys Ile Asp Thr Ser Ile Leu Lys Thr Leu 
        195                 200                 205             

Lys Trp Gly Ala Thr Cys Leu Thr Glu Asp Leu Glu Tyr Thr Met Lys 
    210                 215                 220                 

Met Ala Leu Asn Gly Val Lys Ile Gly Trp Ala His Glu Ala Val Val 
225                 230                 235                 240 

Tyr Asp Glu Lys Pro Ile Thr Leu Lys Gln Ser Trp His Gln Arg Lys 
                245                 250                 255     

Arg Trp Met Gln Gly His Ala Glu Cys Ala Gln Lys Tyr Leu Gly Ala 
            260                 265                 270         

Leu Phe Lys Lys Ala Leu Phe Lys Gly Asp Leu Thr Ser Leu Asp Cys 
        275                 280                 285             

Ala Leu Tyr Leu Phe Gln Pro Ile Arg Phe Ile Phe Val Gly Leu Met 
    290                 295                 300                 

Thr Val Met Met Trp Val Gln Thr Val Tyr Pro Gln Phe Pro Leu Tyr 
305                 310                 315                 320 

Ser Val Gln Tyr Val Phe Pro Val Gln Val Trp Tyr Leu Met Gly Leu 
                325                 330                 335     

Phe Glu Met Phe Tyr Gly Pro Leu Val Ile Leu Ala Glu Lys Lys Phe 
            340                 345                 350         

Ser Leu Lys Val Ile Leu Gly Phe Ile Ile Tyr Pro Tyr Tyr Cys Leu 
        355                 360                 365             

Thr Trp Ile Pro Ile Thr Ile Gln Gly Ile Leu Glu Lys Asn Asn Lys 
    370                 375                 380                 

Glu Trp Asn His Thr Val His Thr Arg Gln Ile Ser Ile Asn Glu Leu 
385                 390                 395                 400 

<210>   227
<211>   395
<212>   PRT
<213>   Pelotomaculum thermopropionicum SI

<400>   227
Glu Ala Ile Phe Tyr Ala Thr Gln Val Phe Leu Thr Leu Phe Thr Phe 
                5                   10                  15      

Tyr His Phe Ile Ile Ser Leu Tyr Gly Phe Tyr Arg Arg His Glu Glu 
            20                  25                  30          

Cys Leu Leu Pro Pro Ser Ser Arg Phe Ala Ile Val Val Ala Ala His 
        35                  40                  45              

Asn Glu Glu Lys Val Ile Gly Glu Leu Ile Arg Asn Leu Asn Glu Leu 
    50                  55                  60                  

Asp Tyr Pro Lys Glu Leu Tyr Asp Val Tyr Val Val Ala Asp Asn Cys 
65                  70                  75                  80  

Thr Asp Ser Thr Ala Lys Ile Ala Arg Glu Lys Gly Ala Val Val Phe 
                85                  90                  95      

Glu Arg Phe Asn Lys Ala Glu Arg Gly Lys Pro Tyr Ala Leu Glu Phe 
            100                 105                 110         

Ala Phe Ser Lys Ile Phe Glu Ser Gly Ile Pro Tyr Asp Ala Val Cys 
        115                 120                 125             

Val Phe Asp Ala Asp Asn Leu Val Asp Thr Asn Phe Leu Thr Val Met 
    130                 135                 140                 

Asn Ala His Leu Leu Lys Gly Glu Lys Ile Ile Gln Gly Tyr Leu Asp 
145                 150                 155                 160 

Thr Lys Asn Ala Gly Asp Thr Trp Ile Thr Lys Ser Ile Tyr Val Ser 
                165                 170                 175     

Tyr Ile Leu Thr Asn Arg Phe Leu Gln Leu Ser Lys Tyr Asn Leu Gly 
            180                 185                 190         

Leu Thr Cys Ala Leu Gly Gly Thr Gly Met Cys Leu Ser Val Asp Val 
        195                 200                 205             

Leu Lys Arg Tyr Gly Trp Gly Met Thr Ser Leu Thr Glu Asp Leu Glu 
    210                 215                 220                 

Phe Gln Thr Lys Ala Leu Leu Asn Gly Ile Lys Val Thr Trp Ala His 
225                 230                 235                 240 

Asp Ala Arg Val Tyr Asp Glu Lys Pro Leu Thr Leu Met Gln Ser Trp 
                245                 250                 255     

Arg Gln Arg Lys Arg Trp Met Gln Gly His Thr Asn Val Ala Gly Arg 
            260                 265                 270         

Tyr Val Ala Arg Leu Val Arg Glu Gly Ile Arg Thr Arg Asn Phe Ala 
        275                 280                 285             

Met Ile Asp Gly Ala Val Tyr Leu Ile Gln Pro Tyr Phe Leu Met Phe 
    290                 295                 300                 

Thr Gly Ile Gly Leu Ile Thr Asn Ile Phe Met Gly Pro Asp Gln Ile 
305                 310                 315                 320 

Leu Asp Arg Pro Val Trp Leu Val Val Gly Phe Phe Ala Gln Phe Phe 
                325                 330                 335     

Tyr Phe Gly Leu Gly Leu Ala Leu Glu Arg Val Lys Pro Val Val Tyr 
            340                 345                 350         

Trp Trp Leu Ile Phe Tyr Pro Ile Phe Ala Leu Thr Trp Ile Pro Val 
        355                 360                 365             

Ala Tyr Val Gly Phe Ala Met Arg Lys Asn Lys Glu Trp Thr His Thr 
    370                 375                 380                 

Leu His Phe Arg Asn Ile Lys His Glu Asn Leu 
385                 390                 395 

<210>   228
<211>   397
<212>   PRT
<213>   Desulfitobacterium hafniense Y51

<400>   228
Val Gln Leu Ile Ile Ile Phe Met Thr Phe Tyr Tyr Phe Val Leu Ser 
                5                   10                  15      

Met Phe Gly Leu Phe Arg Arg Pro Asp Lys Lys Val Leu Glu Pro Glu 
            20                  25                  30          

Lys Ser Phe Ala Leu Val Val Ala Ala His Asn Glu Glu Ala Val Ile 
        35                  40                  45              

Gly Pro Leu Val Asp Asn Leu Leu Asn Leu Asp Tyr Pro Lys Glu Leu 
    50                  55                  60                  

Tyr Asp Val Phe Val Val Ala Asp Asn Cys Thr Asp Lys Thr Ala Leu 
65                  70                  75                  80  

Ile Ala Lys Asn Ala Gly Ala Leu Val His Gln Arg Phe Asn Asn Glu 
                85                  90                  95      

Lys Arg Gly Lys Gly Tyr Ala Leu Glu Trp Met Phe His Arg Leu Phe 
            100                 105                 110         

Lys Leu Glu Arg His Tyr Asp Ala Val Ile Ile Phe Asp Ala Asp Asn 
        115                 120                 125             

Leu Val Asn Glu Thr Phe Leu Val Glu Met Asn Ser Lys Leu Cys Gln 
    130                 135                 140                 

Gly His Gln Ile Val Gln Cys Tyr Leu Asp Ser Lys Asn Pro Tyr Asp 
145                 150                 155                 160 

Thr Trp Val Thr Asn Thr Phe Ser Ile Thr Phe Trp Leu Ser Asn Arg 
                165                 170                 175     

Leu Leu Gln Leu Ala Arg Tyr Asn Thr Gly Phe Leu Asn Asn Val Leu 
            180                 185                 190         

Gly Gly Thr Gly Met Cys Ile Ser Thr Lys Val Leu Lys Asp Leu Gly 
        195                 200                 205             

Trp Gly Ala Thr Ser Leu Thr Glu Asp Leu Glu Phe Thr Met Lys Ala 
    210                 215                 220                 

Leu Ile Ser Gly Ile Lys Thr Thr Trp Ala His Asp Ala Ile Val Tyr 
225                 230                 235                 240 

Asp Glu Lys Pro Leu Thr Phe Ile Gln Ala Trp Asn Gln Arg Lys Arg 
                245                 250                 255     

Trp Ala Gln Gly Gln Val Asp Val Ala Gly Arg Tyr Phe Phe Pro Leu 
            260                 265                 270         

Ile Tyr Lys Ala Phe Lys Glu Arg Lys Leu Met Tyr Phe Asp Ala Ala 
        275                 280                 285             

Val His Leu Phe Gln Pro Ala Leu Val Met Ile Ala Thr Phe Phe Met 
    290                 295                 300                 

Phe Val Asn Leu Ile Ser Gly Leu Gln Ser Ser Tyr Thr Gln Val Phe 
305                 310                 315                 320 

Asn Val Val Met Pro Trp Ser Gly Trp Gln Ile Leu Ser Ala Phe Ser 
                325                 330                 335     

Leu Val Phe Pro Val Ala Ala Leu Ala Leu Glu Arg Leu Pro Trp Arg 
            340                 345                 350         

Ala Tyr Ala Gly Leu Ile Leu Tyr Pro Val Phe Ile Tyr Ser Trp Ile 
        355                 360                 365             

Pro Ile Val Phe Leu Gly Phe Val Asn Arg Lys Asp Lys Ser Trp Ser 
    370                 375                 380                 

His Thr Lys His Thr Arg Ser Ile Lys Tyr Asp Asp Val 
385                 390                 395         

<210>   229
<211>   417
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 222

<400>   229
Met Thr Leu Met Tyr Leu Leu Trp Asp Thr Phe Tyr Asp Ala Leu Lys 
                5                   10                  15      

Leu Val Thr Gly Leu Val Ala Leu Tyr Gln Ile Val Leu Ser Val Tyr 
            20                  25                  30          

Gly Ile Trp His Arg Arg Arg Pro Ile Thr His Ala Pro Gln Lys Arg 
        35                  40                  45              

Phe Ala Ile Ile Ile Pro Ala His Asn Glu Glu Cys Val Ile Gly Pro 
    50                  55                  60                  

Leu Leu Asp Ser Leu Lys Arg Gln Thr Tyr Pro Ala His Leu Tyr Asp 
65                  70                  75                  80  

Val His Val Ile Ala Asp Asn Cys Thr Asp Gly Thr Ala Glu Arg Ala 
                85                  90                  95      

Arg Ala His Gly Ala Ile Val His Val Arg Glu Asn Arg Ala Glu Gln 
            100                 105                 110         

Gly Lys Gly Tyr Ala Ile Glu Trp Met Leu Ala Arg Leu Lys Glu Met 
        115                 120                 125             

Gly Ala Arg Tyr Asp Ala Ile Val Met Phe Asp Ala Asp Asn Leu Val 
    130                 135                 140                 

His Pro Asp Phe Leu Ala Ile Met Asn Asp His Leu Cys Ser Gly Asp 
145                 150                 155                 160 

Arg Val Ile Gln Gly Tyr Leu Asp Thr Lys Asn Pro Phe Asp Ser Trp 
                165                 170                 175     

Ile Ser Val Ser Leu Ala Ile Ser Tyr Trp Phe Asp Asn Arg Leu Trp 
            180                 185                 190         

Gln Tyr Ala Arg Ala Arg Leu His Leu Pro Cys Thr Leu Gly Gly Thr 
        195                 200                 205             

Gly Leu Cys Ile Asp Tyr Pro Leu Leu Gln Glu Met Gly Trp Lys Ala 
    210                 215                 220                 

Thr Gly Leu Thr Glu Asp Leu Glu Phe Gly Ile Arg Cys Val Arg Arg 
225                 230                 235                 240 

Gly Ile Ile Pro Val Trp Ala His Asp Ala Arg Val Tyr Asp Glu Lys 
                245                 250                 255     

Pro Thr Ser Phe Ala Ala Ser Phe Arg Gln Arg Leu Arg Trp Gln Gln 
            260                 265                 270         

Gly His Phe Gln Cys Ala Arg Glu His Leu Val Pro Met Phe Leu Glu 
        275                 280                 285             

Gly Leu Arg Glu Arg Asn Leu Ala Lys Ile Asp Met Ala Ile Tyr Leu 
    290                 295                 300                 

Phe Gln Pro Met Arg Ser Met Leu Leu Phe Ala Gly Ala Met Ile Val 
305                 310                 315                 320 

Leu Gly Leu His Tyr Leu Ser Pro Asp Pro Thr Asp Ala Ala Ser Asn 
                325                 330                 335     

Pro Ala Ala Leu Met Val Thr Asn Leu Trp Val Ala Val Asn Val Ile 
            340                 345                 350         

Leu Phe Leu Glu Val Pro Leu Ala Leu Leu Leu Glu Arg Ile Asn Trp 
        355                 360                 365             

Arg Ala Tyr Phe Ala Leu Pro Leu Leu Pro Phe Phe Leu Trp Thr Trp 
    370                 375                 380                 

Gly Pro Val Thr Leu Gln Ala Tyr Phe Thr Arg Ser Asn Arg Thr Trp 
385                 390                 395                 400 

Tyr His Thr Val His Lys Arg Ala Ile Arg Leu Asp Glu Leu Arg Glu 
                405                 410                 415     

Arg 
    

<210>   230
<211>   417
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 222

<400>   230
Met Thr Leu Met Tyr Leu Leu Trp Asp Thr Phe Tyr Asp Ala Leu Lys 
                5                   10                  15      

Leu Val Thr Gly Leu Val Ala Leu Tyr Gln Ile Val Leu Ser Val Tyr 
            20                  25                  30          

Gly Ile Trp His Arg Arg Arg Pro Ile Thr His Ala Pro Gln Lys Arg 
        35                  40                  45              

Phe Ala Ile Ile Ile Pro Ala His Asn Glu Glu Cys Val Ile Gly Pro 
    50                  55                  60                  

Leu Leu Asp Ser Leu Lys Arg Gln Thr Tyr Pro Ala His Leu Tyr Asp 
65                  70                  75                  80  

Val His Val Ile Ala Asp Asn Cys Thr Asp Gly Thr Ala Glu Arg Ala 
                85                  90                  95      

Arg Ala His Gly Ala Ile Val His Val Arg Glu Asn Arg Ala Glu Gln 
            100                 105                 110         

Gly Lys Gly Tyr Ala Ile Glu Trp Met Leu Ala Arg Leu Lys Glu Met 
        115                 120                 125             

Gly Ala Arg Tyr Asp Ala Ile Val Met Phe Asp Ala Asp Asn Leu Val 
    130                 135                 140                 

His Pro Asp Phe Leu Ala Ile Met Asn Asp His Leu Cys Ser Gly Asp 
145                 150                 155                 160 

Arg Val Ile Gln Gly Tyr Leu Asp Thr Lys Asn Pro Phe Asp Ser Trp 
                165                 170                 175     

Ile Ser Val Ser Leu Ala Ile Ser Tyr Trp Phe Asp Asn Arg Leu Trp 
            180                 185                 190         

Gln Tyr Ala Arg Ala Arg Leu His Leu Pro Cys Thr Leu Gly Gly Thr 
        195                 200                 205             

Gly Leu Cys Ile Asp Tyr Pro Leu Leu Gln Glu Met Gly Trp Lys Ala 
    210                 215                 220                 

Thr Gly Leu Thr Glu Asp Leu Glu Phe Gly Ile Arg Cys Val Arg Arg 
225                 230                 235                 240 

Gly Ile Ile Pro Val Trp Ala His Asp Ala Arg Val Tyr Asp Glu Lys 
                245                 250                 255     

Pro Thr Ser Phe Ala Ala Ser Phe Arg Gln Arg Leu Arg Trp Gln Gln 
            260                 265                 270         

Gly His Phe Gln Cys Ala Arg Glu His Leu Val Pro Met Phe Leu Glu 
        275                 280                 285             

Gly Leu Arg Asp Arg Asn Leu Ala Lys Ile Asp Met Ala Ile Tyr Leu 
    290                 295                 300                 

Phe Gln Pro Met Arg Ser Met Leu Leu Phe Ala Gly Ala Met Ile Val 
305                 310                 315                 320 

Leu Gly Leu His Tyr Leu Ser Pro Asp Pro Thr Asp Ala Ala Ser Asn 
                325                 330                 335     

Pro Ala Ala Leu Met Val Thr Asn Leu Trp Val Ala Val Asn Val Ile 
            340                 345                 350         

Leu Phe Leu Glu Val Pro Leu Ala Leu Leu Leu Glu Arg Val Asn Trp 
        355                 360                 365             

Arg Ala Tyr Phe Ala Leu Pro Leu Leu Pro Phe Phe Leu Trp Thr Trp 
    370                 375                 380                 

Gly Pro Val Thr Leu Gln Ala Tyr Phe Thr Arg Ser Asn Arg Thr Trp 
385                 390                 395                 400 

Tyr His Thr Val His Lys Arg Ala Ile Arg Leu Asp Glu Leu Arg Glu 
                405                 410                 415     

Arg 
    

<210>   231
<211>   417
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 222

<400>   231
Met Thr Leu Met Tyr Leu Leu Trp Asp Thr Phe Tyr Asp Ala Leu Lys 
                5                   10                  15      

Leu Val Thr Gly Leu Val Ala Leu Tyr Gln Ile Val Leu Ser Val Tyr 
            20                  25                  30          

Gly Ile Trp His Arg Arg Arg Pro Ile Thr His Ala Pro Gln Lys Arg 
        35                  40                  45              

Phe Ala Ile Ile Ile Pro Ala His Asn Glu Glu Cys Val Ile Gly Pro 
    50                  55                  60                  

Leu Leu Asp Ser Leu Lys Arg Gln Thr Tyr Pro Ala His Leu Tyr Asp 
65                  70                  75                  80  

Val His Val Ile Ala Asp Asn Cys Thr Asp Gly Thr Ala Glu Arg Ala 
                85                  90                  95      

Arg Ala His Gly Ala Ile Val His Val Arg Glu Asn Arg Ala Glu Gln 
            100                 105                 110         

Gly Lys Gly Tyr Ala Ile Glu Trp Met Leu Ala Arg Leu Lys Glu Met 
        115                 120                 125             

Gly Ala Arg Tyr Asp Ala Ile Val Met Phe Asp Ala Asp Asn Leu Val 
    130                 135                 140                 

His Pro Asp Phe Leu Ala Ile Met Asn Asp His Leu Cys Ser Gly Asp 
145                 150                 155                 160 

Arg Val Ile Gln Gly Tyr Leu Asp Thr Lys Asn Pro Phe Asp Ser Trp 
                165                 170                 175     

Ile Ser Val Ser Leu Ala Ile Ser Tyr Trp Phe Asp Asn Arg Leu Trp 
            180                 185                 190         

Gln Tyr Ala Arg Ala Arg Leu His Leu Pro Cys Thr Leu Gly Gly Thr 
        195                 200                 205             

Gly Leu Cys Ile Asp Tyr Pro Leu Leu Gln Glu Met Gly Trp Lys Ala 
    210                 215                 220                 

Thr Gly Leu Thr Glu Asp Leu Glu Phe Gly Ile Arg Cys Val Arg Arg 
225                 230                 235                 240 

Gly Ile Ile Pro Val Trp Ala His Asp Ala Arg Val Tyr Asp Glu Lys 
                245                 250                 255     

Pro Thr Ser Phe Ala Ala Ser Phe Arg Gln Arg Leu Arg Trp Gln Gln 
            260                 265                 270         

Gly His Phe Gln Cys Ala Arg Glu His Leu Val Pro Met Phe Leu Glu 
        275                 280                 285             

Gly Leu Arg Glu Arg Asn Leu Ala Lys Ile Asp Met Ala Ile Tyr Leu 
    290                 295                 300                 

Phe Gln Pro Met Arg Ser Met Leu Leu Phe Ala Gly Ala Met Ile Val 
305                 310                 315                 320 

Leu Gly Leu His Tyr Leu Ser Pro Asp Pro Thr Asp Ala Ala Ser Asn 
                325                 330                 335     

Pro Ala Ala Leu Met Val Thr Gln Leu Trp Val Ala Val Asn Val Ile 
            340                 345                 350         

Leu Phe Leu Glu Val Pro Leu Ala Leu Leu Leu Glu Arg Val Asn Trp 
        355                 360                 365             

Arg Ala Tyr Phe Ala Leu Pro Leu Leu Pro Phe Phe Leu Trp Thr Trp 
    370                 375                 380                 

Gly Pro Val Thr Leu Gln Ala Tyr Phe Thr Arg Ser Asn Arg Thr Trp 
385                 390                 395                 400 

Tyr His Thr Val His Lys Arg Ala Ile Arg Leu Asp Glu Leu Arg Glu 
                405                 410                 415     

Arg 
    

<210>   232
<211>   417
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 222

<400>   232
Met Thr Leu Met Tyr Leu Leu Trp Asp Thr Phe Tyr Asp Ala Leu Lys 
                5                   10                  15      

Leu Val Thr Gly Leu Val Ala Leu Tyr Gln Ile Val Leu Ser Val Tyr 
            20                  25                  30          

Gly Ile Trp His Arg Arg Arg Pro Ile Thr His Ala Pro Gln Lys Arg 
        35                  40                  45              

Phe Ala Ile Ile Ile Pro Ala His Asn Glu Glu Cys Val Ile Gly Pro 
    50                  55                  60                  

Leu Leu Asp Ser Leu Lys Arg Gln Thr Tyr Pro Ala His Leu Tyr Asp 
65                  70                  75                  80  

Val His Val Ile Ala Asp Asn Cys Thr Asp Gly Thr Ala Glu Arg Ala 
                85                  90                  95      

Arg Ala His Gly Ala Ile Val His Val Arg Glu Asn Arg Ala Glu Gln 
            100                 105                 110         

Gly Lys Gly Tyr Ala Ile Glu Trp Met Leu Ala Arg Leu Lys Glu Met 
        115                 120                 125             

Gly Ala Arg Tyr Asp Ala Ile Val Met Phe Asp Ala Asp Asn Leu Val 
    130                 135                 140                 

His Pro Asp Phe Leu Ala Ile Met Asn Asp His Leu Cys Ser Gly Asp 
145                 150                 155                 160 

Arg Val Ile Gln Gly Tyr Leu Asp Thr Lys Asn Pro Phe Asp Ser Trp 
                165                 170                 175     

Ile Ser Val Ser Leu Ala Ile Ser Tyr Trp Phe Asp Asn Arg Leu Trp 
            180                 185                 190         

Gln Tyr Ala Arg Ala Arg Leu His Leu Pro Cys Thr Leu Gly Gly Thr 
        195                 200                 205             

Gly Leu Cys Ile Asp Tyr Pro Leu Leu Gln Glu Met Gly Trp Lys Ala 
    210                 215                 220                 

Thr Gly Leu Thr Glu Asp Leu Glu Phe Gly Ile Arg Cys Val Arg Arg 
225                 230                 235                 240 

Gly Ile Ile Pro Val Trp Ala His Asp Ala Arg Val Tyr Asp Glu Lys 
                245                 250                 255     

Pro Thr Ser Phe Ala Ala Ser Phe Arg Gln Arg Leu Arg Trp Gln Gln 
            260                 265                 270         

Gly His Phe Gln Cys Ala Arg Glu His Leu Val Pro Met Phe Leu Glu 
        275                 280                 285             

Gly Leu Arg Glu Arg Asn Leu Ala Lys Ile Asp Met Ala Ile Tyr Leu 
    290                 295                 300                 

Phe Gln Pro Met Arg Ser Met Leu Leu Phe Ala Gly Ala Met Ile Val 
305                 310                 315                 320 

Leu Gly Leu His Tyr Leu Ser Pro Asp Pro Thr Asp Ala Ala Ser Asn 
                325                 330                 335     

Pro Ala Ala Leu Met Val Thr Asn Leu Trp Val Ala Val Asn Val Ile 
            340                 345                 350         

Leu Phe Leu Glu Val Pro Leu Ala Leu Leu Leu Glu Arg Val Asn Trp 
        355                 360                 365             

Arg Ala Tyr Phe Ala Leu Pro Leu Leu Pro Phe Phe Leu Trp Thr Trp 
    370                 375                 380                 

Gly Pro Val Thr Leu Gln Ala Tyr Phe Thr Arg Ser Asn Arg Thr Trp 
385                 390                 395                 400 

Tyr His Thr Ile His Lys Arg Ala Ile Arg Leu Asp Glu Leu Arg Glu 
                405                 410                 415     

Arg 
    

<210>   233
<211>   417
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 222

<400>   233
Met Thr Leu Met Tyr Leu Leu Trp Asp Thr Phe Tyr Asp Ala Leu Lys 
                5                   10                  15      

Leu Val Thr Gly Leu Val Ala Leu Tyr Gln Ile Val Leu Ser Val Tyr 
            20                  25                  30          

Gly Leu Trp His Arg Arg Arg Pro Ile Thr His Ala Pro Gln Lys Arg 
        35                  40                  45              

Phe Ala Ile Ile Ile Pro Ala His Asn Glu Glu Cys Val Ile Gly Pro 
    50                  55                  60                  

Leu Leu Asp Ser Leu Lys Arg Gln Thr Tyr Pro Ala His Leu Tyr Asp 
65                  70                  75                  80  

Val His Val Ile Ala Asp Asn Cys Thr Asp Gly Thr Ala Glu Arg Ala 
                85                  90                  95      

Arg Ala His Gly Ala Ile Val His Val Arg Glu Asn Arg Ala Glu Gln 
            100                 105                 110         

Gly Lys Gly Tyr Ala Ile Glu Trp Met Leu Ala Arg Leu Lys Glu Met 
        115                 120                 125             

Gly Ala Arg Tyr Asp Ala Ile Val Met Phe Asp Ala Asp Asn Leu Val 
    130                 135                 140                 

His Pro Asp Phe Leu Ala Ile Met Asn Asp His Leu Cys Ser Gly Asp 
145                 150                 155                 160 

Arg Val Ile Gln Gly Tyr Leu Asp Thr Lys Asn Pro Phe Asp Ser Trp 
                165                 170                 175     

Ile Ser Val Ser Leu Ala Ile Ser Tyr Trp Phe Asp Asn Arg Leu Trp 
            180                 185                 190         

Gln Tyr Ala Arg Ala Arg Leu His Leu Pro Cys Thr Leu Gly Gly Thr 
        195                 200                 205             

Gly Leu Cys Ile Asp Tyr Pro Leu Leu Gln Glu Met Gly Trp Lys Ala 
    210                 215                 220                 

Thr Gly Leu Thr Glu Asp Leu Glu Phe Gly Ile Arg Cys Val Arg Arg 
225                 230                 235                 240 

Gly Ile Ile Pro Val Trp Ala His Asp Ala Arg Val Tyr Asp Glu Lys 
                245                 250                 255     

Pro Thr Ser Phe Ala Ala Ser Phe Arg Gln Arg Leu Arg Trp Gln Gln 
            260                 265                 270         

Gly His Phe Gln Cys Ala Arg Glu His Leu Val Pro Met Phe Leu Glu 
        275                 280                 285             

Gly Leu Arg Glu Arg Asn Leu Ala Lys Ile Asp Met Ala Ile Tyr Leu 
    290                 295                 300                 

Phe Gln Pro Met Arg Ser Met Leu Leu Phe Ala Gly Ala Met Ile Val 
305                 310                 315                 320 

Leu Gly Leu His Tyr Leu Ser Pro Asp Pro Thr Asp Ala Ala Ser Asn 
                325                 330                 335     

Pro Ala Ala Leu Met Val Thr Asn Leu Trp Val Ala Val Asn Val Ile 
            340                 345                 350         

Leu Phe Leu Glu Val Pro Leu Ala Leu Leu Leu Glu Arg Val Asn Trp 
        355                 360                 365             

Arg Ala Tyr Phe Ala Leu Pro Leu Leu Pro Phe Phe Leu Trp Thr Trp 
    370                 375                 380                 

Gly Pro Val Thr Leu Gln Ala Tyr Phe Thr Arg Ser Asn Arg Thr Trp 
385                 390                 395                 400 

Tyr His Thr Val His Lys Arg Ala Ile Arg Leu Asp Glu Leu Arg Glu 
                405                 410                 415     

Arg 
    

<210>   234
<211>   1254
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 223

<400>   234
atgacattga tgtacttgct ctgggacacg ttctatgacg cgctgaagct cgtcacgggc       60

cttgtggcgc tgtaccagat tgtgctgtcc gtgtacggca tctggcaccg cagacggccc      120

atcacgcatg cgccgcagaa gcgcttcgcc atcatcattc cggcgcacaa cgaggagtgc      180

gtgatcggcc cgctcctcga cagcctgaag cgccagacgt atcccgcgca cctgtacgac      240

gtgcatgtca tcgcggacaa ctgcacggac ggcaccgcgg agcgcgcgcg ggcgcacggc      300

gccattgtcc acgtgcgcga aaaccgcgcg gaacagggca aggggtacgc catcgaatgg      360

atgctggcgc gcctgaagga aatgggcgct cgatacgacg ccatcgtgat gttcgacgcg      420

gataatttgg ttcatccgga ctttctcgcc atcatgaacg accacctgtg cagcggcgat      480

cgcgtcattc agggatatct ggataccaag aatccattcg attcgtggat cagcgtgtcg      540

ctcgccatct cctattggtt cgacaatcgg ctgtggcagt acgcccgcgc ccgcctgcat      600

ctgccgtgta cgctcggtgg gaccggcctt tgcatcgatt atccgctgtt gcaggagatg      660

ggatggaagg cgacgggcct caccgaggat ctcgagttcg ggattcgctg cgtccgccga      720

ggaattatcc ccgtctgggc gcacgacgcg cgcgtctacg acgagaagcc gacgagcttc      780

gcggcgtctt tccgccagcg cctgcgctgg cagcaggggc atttccaatg tgcacgtgaa      840

cacttggtcc ccatgtttct cgaggggctg cgcgagcgga acttggccaa aatcgacatg      900

gccatttacc tgtttcagcc catgcggtcc atgctgctgt ttgcgggcgc catgattgtg      960

ctcggccttc actacctgtc gcccgatccg accgatgcag cgtccaaccc ggccgcgctc     1020

atggtcacga atctgtgggt cgcggtgaac gtgatcctgt ttctcgaggt tcccctcgcg     1080

ctgctgctcg aacggattaa ctggcgggcg tattttgccc tgcccctcct tccgttcttt     1140

ctctggacct ggggccccgt gacgctgcag gcctacttca cgcgcagcaa ccggacgtgg     1200

taccacacgg tgcacaagcg cgccattcgc ttggatgagc tgcgcgagcg gtaa           1254


<210>   235
<211>   1254
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 223

<400>   235
atgacattga tgtacttgct ctgggacacg ttctatgacg cgctgaagct cgtcacgggc       60

cttgtggcgc tgtaccagat tgtgctgtcc gtgtacggca tctggcaccg cagacggccc      120

atcacgcatg cgccgcagaa gcgcttcgcc atcatcattc cggcgcacaa cgaggagtgc      180

gtgatcggcc cgctcctcga cagcctgaag cgccagacgt atcccgcgca cctgtacgac      240

gtgcatgtca tcgcggacaa ctgcacggac ggcaccgcgg agcgcgcgcg ggcgcacggc      300

gccattgtcc acgtgcgcga aaaccgcgcg gaacagggca aggggtacgc catcgaatgg      360

atgctggcgc gcctgaagga aatgggcgct cgatacgacg ccatcgtgat gttcgacgcg      420

gataatttgg ttcatccgga ctttctcgcc atcatgaacg accacctgtg cagcggcgat      480

cgcgtcattc agggatatct ggataccaag aatccattcg attcgtggat cagcgtgtcg      540

ctcgccatct cctattggtt cgacaatcgg ctgtggcagt acgcccgcgc ccgcctgcat      600

ctgccgtgta cgctcggtgg gaccggcctt tgcatcgatt atccgctgtt gcaggagatg      660

ggatggaagg cgacgggcct caccgaggat ctcgagttcg ggattcgctg cgtccgccga      720

ggaattatcc ccgtctgggc gcacgacgcg cgcgtctacg acgagaagcc gacgagcttc      780

gcggcgtctt tccgccagcg cctgcgctgg cagcaggggc atttccaatg tgcacgtgaa      840

cacttggtcc ccatgtttct cgaggggctg cgcgatcgga acttggccaa aatcgacatg      900

gccatttacc tgtttcagcc catgcggtcc atgctgctgt ttgcgggcgc catgattgtg      960

ctcggccttc actacctgtc gcccgatccg accgatgcag cgtccaaccc ggccgcgctc     1020

atggtcacga atctgtgggt cgcggtgaac gtgatcctgt ttctcgaggt tcccctcgcg     1080

ctgctgctcg aacgggtgaa ctggcgggcg tattttgccc tgcccctcct tccgttcttt     1140

ctctggacct ggggccccgt gacgctgcag gcctacttca cgcgcagcaa ccggacgtgg     1200

taccacacgg tgcacaagcg cgccattcgc ttggatgagc tgcgcgagcg gtaa           1254


<210>   236
<211>   1254
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 223

<400>   236
atgacattga tgtacttgct ctgggacacg ttctatgacg cgctgaagct cgtcacgggc       60

cttgtggcgc tgtaccagat tgtgctgtcc gtgtacggca tctggcaccg cagacggccc      120

atcacgcatg cgccgcagaa gcgcttcgcc atcatcattc cggcgcacaa cgaggagtgc      180

gtgatcggcc cgctcctcga cagcctgaag cgccagacgt atcccgcgca cctgtacgac      240

gtgcatgtca tcgcggacaa ctgcacggac ggcaccgcgg agcgcgcgcg ggcgcacggc      300

gccattgtcc acgtgcgcga aaaccgcgcg gaacagggca aggggtacgc catcgaatgg      360

atgctggcgc gcctgaagga aatgggcgct cgatacgacg ccatcgtgat gttcgacgcg      420

gataatttgg ttcatccgga ctttctcgcc atcatgaacg accacctgtg cagcggcgat      480

cgcgtcattc agggatatct ggataccaag aatccattcg attcgtggat cagcgtgtcg      540

ctcgccatct cctattggtt cgacaatcgg ctgtggcagt acgcccgcgc ccgcctgcat      600

ctgccgtgta cgctcggtgg gaccggcctt tgcatcgatt atccgctgtt gcaggagatg      660

ggatggaagg cgacgggcct caccgaggat ctcgagttcg ggattcgctg cgtccgccga      720

ggaattatcc ccgtctgggc gcacgacgcg cgcgtctacg acgagaagcc gacgagcttc      780

gcggcgtctt tccgccagcg cctgcgctgg cagcaggggc atttccaatg tgcacgtgaa      840

cacttggtcc ccatgtttct cgaggggctg cgcgagcgga acttggccaa aatcgacatg      900

gccatttacc tgtttcagcc catgcggtcc atgctgctgt ttgcgggcgc catgattgtg      960

ctcggccttc actacctgtc gcccgatccg accgatgcag cgtccaaccc ggccgcgctc     1020

atggtcacgc aactgtgggt cgcggtgaac gtgatcctgt ttctcgaggt tcccctcgcg     1080

ctgctgctcg aacgggtgaa ctggcgggcg tattttgccc tgcccctcct tccgttcttt     1140

ctctggacct ggggccccgt gacgctgcag gcctacttca cgcgcagcaa ccggacgtgg     1200

taccacacgg tgcacaagcg cgccattcgc ttggatgagc tgcgcgagcg gtaa           1254


<210>   237
<211>   1254
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 223

<400>   237
atgacattga tgtacttgct ctgggacacg ttctatgacg cgctgaagct cgtcacgggc       60

cttgtggcgc tgtaccagat tgtgctgtcc gtgtacggca tctggcaccg cagacggccc      120

atcacgcatg cgccgcagaa gcgcttcgcc atcatcattc cggcgcacaa cgaggagtgc      180

gtgatcggcc cgctcctcga cagcctgaag cgccagacgt atcccgcgca cctgtacgac      240

gtgcatgtca tcgcggacaa ctgcacggac ggcaccgcgg agcgcgcgcg ggcgcacggc      300

gccattgtcc acgtgcgcga aaaccgcgcg gaacagggca aggggtacgc catcgaatgg      360

atgctggcgc gcctgaagga aatgggcgct cgatacgacg ccatcgtgat gttcgacgcg      420

gataatttgg ttcatccgga ctttctcgcc atcatgaacg accacctgtg cagcggcgat      480

cgcgtcattc agggatatct ggataccaag aatccattcg attcgtggat cagcgtgtcg      540

ctcgccatct cctattggtt cgacaatcgg ctgtggcagt acgcccgcgc ccgcctgcat      600

ctgccgtgta cgctcggtgg gaccggcctt tgcatcgatt atccgctgtt gcaggagatg      660

ggatggaagg cgacgggcct caccgaggat ctcgagttcg ggattcgctg cgtccgccga      720

ggaattatcc ccgtctgggc gcacgacgcg cgcgtctacg acgagaagcc gacgagcttc      780

gcggcgtctt tccgccagcg cctgcgctgg cagcaggggc atttccaatg tgcacgtgaa      840

cacttggtcc ccatgtttct cgaggggctg cgcgagcgga acttggccaa aatcgacatg      900

gccatttacc tgtttcagcc catgcggtcc atgctgctgt ttgcgggcgc catgattgtg      960

ctcggccttc actacctgtc gcccgatccg accgatgcag cgtccaaccc ggccgcgctc     1020

atggtcacga atctgtgggt cgcggtgaac gtgatcctgt ttctcgaggt tcccctcgcg     1080

ctgctgctcg aacgggtgaa ctggcgggcg tattttgccc tgcccctcct tccgttcttt     1140

ctctggacct ggggccccgt gacgctgcag gcctacttca cgcgcagcaa ccggacgtgg     1200

taccacacga ttcacaagcg cgccattcgc ttggatgagc tgcgcgagcg gtaa           1254


<210>   238
<211>   1254
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 223

<400>   238
atgacattga tgtacttgct ctgggacacg ttctatgacg cgctgaagct cgtcacgggc       60

cttgtggcgc tgtaccagat tgtgctgtcc gtgtacggct tatggcaccg cagacggccc      120

atcacgcatg cgccgcagaa gcgcttcgcc atcatcattc cggcgcacaa cgaggagtgc      180

gtgatcggcc cgctcctcga cagcctgaag cgccagacgt atcccgcgca cctgtacgac      240

gtgcatgtca tcgcggacaa ctgcacggac ggcaccgcgg agcgcgcgcg ggcgcacggc      300

gccattgtcc acgtgcgcga aaaccgcgcg gaacagggca aggggtacgc catcgaatgg      360

atgctggcgc gcctgaagga aatgggcgct cgatacgacg ccatcgtgat gttcgacgcg      420

gataatttgg ttcatccgga ctttctcgcc atcatgaacg accacctgtg cagcggcgat      480

cgcgtcattc agggatatct ggataccaag aatccattcg attcgtggat cagcgtgtcg      540

ctcgccatct cctattggtt cgacaatcgg ctgtggcagt acgcccgcgc ccgcctgcat      600

ctgccgtgta cgctcggtgg gaccggcctt tgcatcgatt atccgctgtt gcaggagatg      660

ggatggaagg cgacgggcct caccgaggat ctcgagttcg ggattcgctg cgtccgccga      720

ggaattatcc ccgtctgggc gcacgacgcg cgcgtctacg acgagaagcc gacgagcttc      780

gcggcgtctt tccgccagcg cctgcgctgg cagcaggggc atttccaatg tgcacgtgaa      840

cacttggtcc ccatgtttct cgaggggctg cgcgagcgga acttggccaa aatcgacatg      900

gccatttacc tgtttcagcc catgcggtcc atgctgctgt ttgcgggcgc catgattgtg      960

ctcggccttc actacctgtc gcccgatccg accgatgcag cgtccaaccc ggccgcgctc     1020

atggtcacga atctgtgggt cgcggtgaac gtgatcctgt ttctcgaggt tcccctcgcg     1080

ctgctgctcg aacgggtgaa ctggcgggcg tattttgccc tgcccctcct tccgttcttt     1140

ctctggacct ggggccccgt gacgctgcag gcctacttca cgcgcagcaa ccggacgtgg     1200

taccacacgg tgcacaagcg cgccattcgc ttggatgagc tgcgcgagcg gtaa           1254


<210>   239
<211>   307
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   239
Met Thr Met Arg Ile Ala Val Leu Ile Pro Cys Tyr Asn Glu Glu Leu 
                5                   10                  15      

Thr Ile Gly Lys Val Val Gln Asp Phe Arg Arg Glu Leu Pro Asp Ala 
            20                  25                  30          

Glu Ile Tyr Val Tyr Asp Asn Asn Ser Arg Asp Arg Thr Ala Glu Val 
        35                  40                  45              

Ala Arg Glu Ala Gly Ala Ile Val Arg Arg Glu Thr Arg Gln Gly Lys 
    50                  55                  60                  

Gly Asn Val Val Arg Ser Met Phe Arg Asp Ile Asp Ala Asp Val Tyr 
65                  70                  75                  80  

Val Met Thr Asp Gly Asp Asp Thr Tyr Pro Ala Glu Phe Val His Asp 
                85                  90                  95      

Leu Ile Arg Pro Ile Ile Glu Gly Glu Ala Asp Met Cys Ile Gly Asp 
            100                 105                 110         

Arg His Ser Asp Gly Ser Tyr Ser Lys Glu Asn Lys Arg Pro Phe His 
        115                 120                 125             

Asn Phe Gly Asn Gln Leu Val Arg Lys Leu Ile Asn Thr Leu Phe His 
    130                 135                 140                 

Ala Asp Leu Arg Asp Ile Met Thr Gly Tyr Arg Ala Phe Ser Arg Arg 
145                 150                 155                 160 

Phe Ala Lys Thr Met Pro Ile Gln Ser Glu Gly Phe Glu Ile Glu Thr 
                165                 170                 175     

Glu Met Thr Leu His Ala Leu Asp Lys Arg Phe Arg Ile Leu Glu Ile 
            180                 185                 190         

Pro Ile Gln Tyr Arg Asp Arg Pro Pro Gly Ser His Ser Lys Leu Asn 
        195                 200                 205             

Thr Leu Ser Asp Gly Ile Arg Val Leu Lys Thr Val Phe Trp Ile Phe 
    210                 215                 220                 

Lys Asp Tyr Lys Pro Leu Ala Phe Phe Thr Ala Val Ala Leu Ile Leu 
225                 230                 235                 240 

Phe Leu Ala Gly Leu Gly Val Gly Ile Pro Val Leu Tyr Glu Tyr Phe 
                245                 250                 255     

Ser Phe Gly Arg Ile Ala Lys Ile Pro Ser Ala Ile Leu Ala Val Gly 
            260                 265                 270         

Phe Met Val Leu Ala Thr Asn Ser Leu Thr Cys Gly Phe Ile Leu Asp 
        275                 280                 285             

Thr Ile Val Arg His His Arg Asp Tyr Tyr Glu Leu Leu Gln Asn Glu 
    290                 295                 300                 

Phe Lys Gly 
305         

<210>   240
<211>   924
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   240
gtgaccatgc gaatcgcagt cctcatcccg tgttacaacg aagaactgac cattggaaaa       60

gtggttcagg actttaggcg cgaactgccc gacgcggaga tttacgtgta cgacaacaac      120

tcgcgcgatc gcaccgcgga agtggcgagg gaagcgggcg cgattgtgcg aagagagact      180

cgtcagggca agggaaacgt ggtgcgctcg atgttccgcg acatcgacgc cgacgtgtac      240

gtcatgaccg acggagacga cacgtacccg gcggaattcg tgcacgatct cattcggccg      300

atcatcgaag gagaggccga catgtgcatc ggcgaccgtc actccgacgg ctcgtactcc      360

aaggagaaca agcgcccttt ccacaacttc ggcaaccagt tggtgcggaa gctgatcaac      420

accctgtttc acgcagatct ccgggacatc atgaccggct accgggcgtt cagccgccgc      480

ttcgccaaga ccatgcccat ccagagcgag ggctttgaaa tcgagacgga aatgacgctc      540

cacgcgctgg acaagcgctt ccgcatcctc gaaatcccga tccaataccg ggatcggccg      600

ccgggcagcc actccaagtt gaacacgctg agcgacggca tccgggtgtt gaagaccgtc      660

ttttggattt tcaaagacta caagccgctc gctttcttca ccgccgtcgc cttgatcctg      720

tttttggccg gcctcggcgt cggcattccc gtgttgtacg agtacttctc gtttggccgc      780

atcgcgaaga tcccgtccgc catcctcgcg gtcggattca tggtgctggc gaccaacagc      840

ctgacgtgcg gctttattct ggacaccatc gtccgccatc accgcgacta ctacgagctc      900

ttgcagaacg aatttaaagg ctga                                             924


<210>   241
<211>   304
<212>   PRT
<213>   Clostridium acetobutylicum ATCC 824

<400>   241
Met Lys Ile Ala Val Leu Ile Pro Cys Tyr Asn Glu Glu Leu Thr Ile 
                5                   10                  15      

Lys Lys Val Ile Thr Asp Phe Lys Lys Val Leu Pro Asp Ala Tyr Ile 
            20                  25                  30          

Tyr Val Tyr Asp Asn Asn Ser Lys Asp Asn Thr Ala Ala Ile Ala Lys 
        35                  40                  45              

Glu Ser Gly Ala Ile Val Val Arg Glu Pro Arg Gln Gly Lys Gly Asn 
    50                  55                  60                  

Val Val Arg Ser Met Phe Lys Asp Ile Asp Ala Asp Tyr Tyr Ile Met 
65                  70                  75                  80  

Val Asp Gly Asp Asp Thr Tyr Pro Ala Glu Phe Ala Lys Glu Leu Leu 
                85                  90                  95      

Lys Pro Ile Ile Asn Gly Glu Ala Asp Met Thr Ile Gly Asp Arg Leu 
            100                 105                 110         

Ser Asn Gly Thr Tyr Glu Ser Glu Asn Lys Arg Ala Phe His Asn Phe 
        115                 120                 125             

Gly Asn Lys Leu Val Lys Asn Leu Ile Gly Lys Leu Phe Lys Asn Asp 
    130                 135                 140                 

Ile Asn Asp Ile Met Thr Gly Tyr Arg Ala Phe Asn Arg Tyr Phe Val 
145                 150                 155                 160 

Lys Thr Ile Pro Val Leu Ser Ser Gly Phe Glu Ile Glu Thr Glu Met 
                165                 170                 175     

Ser Ile His Ala Leu Asp Lys Lys Phe Leu Leu Lys Glu Ile Pro Ile 
            180                 185                 190         

Asp Tyr Arg Asp Arg Pro Glu Gly Ser Ser Ser Lys Leu Asn Thr Tyr 
        195                 200                 205             

Lys Asp Gly Leu Lys Val Ile Lys Thr Ile Leu Phe Leu Phe Lys Asp 
    210                 215                 220                 

Tyr Lys Pro Leu Pro Phe Phe Ser Ile Leu Ala Leu Leu Ile Phe Leu 
225                 230                 235                 240 

Ile Gly Leu Leu Val Gly Ser Pro Val Ile Ile Glu Phe Val Lys Thr 
                245                 250                 255     

His Arg Ile Ser Lys Leu Pro Ser Ala Val Leu Thr Met Gly Leu Ile 
            260                 265                 270         

Thr Ser Ala Ile Met Phe Phe Val Asn Gly Leu Ile Leu Asp Thr Leu 
        275                 280                 285             

Val Lys Gln Asn Asn Gln Asn Tyr Glu Leu Phe Leu Asn Asn Tyr Lys 
    290                 295                 300                 

<210>   242
<211>   300
<212>   PRT
<213>   Streptococcus mutans UA159

<400>   242
Met Thr Glu Lys Ile Ala Ile Leu Leu Pro Ala Tyr Asn Glu Glu Ile 
                5                   10                  15      

Thr Ile Gln Lys Val Ile Ser Asp Phe Lys Arg Val Leu Pro Glu Ala 
            20                  25                  30          

Asp Ile Tyr Val Tyr Asp Asn Asn Ser Lys Asp Arg Thr Asn Glu Leu 
        35                  40                  45              

Ala Arg Gln Ala Gly Ala Ile Val Arg Phe Glu Ser Arg Gln Gly Lys 
    50                  55                  60                  

Gly Asn Val Val Arg Ser Met Phe Arg Glu Ile Asn Ala Asp Tyr Tyr 
65                  70                  75                  80  

Ile Met Val Asp Ala Asp Asp Thr Tyr Pro Ala Asp Glu Val Gln Lys 
                85                  90                  95      

Leu Leu Asp Pro Leu Arg Ser Gly Lys Ala Asp Met Thr Ile Gly Asp 
            100                 105                 110         

Arg Leu Ser Asn Gly Thr Tyr Ala Glu Glu Asn Lys Arg Gly Phe His 
        115                 120                 125             

Gly Phe Gly Asn Asn Leu Val Arg Leu Leu Val Asn His Leu Tyr Gln 
    130                 135                 140                 

Gly Asn Tyr Gln Asp Ile Met Thr Gly Tyr Arg Gly Phe Asn Arg Leu 
145                 150                 155                 160 

Phe Val Lys Asn Phe Pro Val Leu Ser Ser Gly Phe Glu Ile Glu Thr 
                165                 170                 175     

Glu Leu Ser Ile His Ser Leu Asp Lys Arg Phe Lys Leu Val Glu Val 
            180                 185                 190         

Pro Ile Thr Tyr His Asp Arg Pro Glu Gly Ser Glu Ser Lys Leu Asn 
        195                 200                 205             

Thr Phe Ser Asp Gly Phe Lys Val Leu Cys Met Ile Phe Asn Leu Phe 
    210                 215                 220                 

Lys Asp Tyr Lys Pro Leu Ile Phe Phe Ser Leu Val Thr Leu Phe Phe 
225                 230                 235                 240 

Phe Ile Leu Gly Leu Ile Val Gly Val Pro Val Val Thr Glu Phe Ala 
                245                 250                 255     

Glu Thr Gly Phe Ile Ala Lys Met Pro Ser Ala Ile Leu Ala Thr Gly 
            260                 265                 270         

Phe Met Ile Leu Ala Ala Leu Ser Phe Ala Leu Gly Phe Ile Leu Asp 
        275                 280                 285             

Thr Ile Val Arg Gln Asn Arg Met Gln Tyr Glu Leu 
    290                 295                 300 

<210>   243
<211>   300
<212>   PRT
<213>   Streptococcus mutans

<400>   243
Met Thr Glu Lys Ile Ala Val Leu Leu Pro Ala Tyr Asn Glu Glu Ile 
                5                   10                  15      

Thr Ile Glu Arg Val Ile Lys Asp Phe Gln Asn Val Leu Pro Asn Ala 
            20                  25                  30          

Asp Ile Tyr Val Tyr Asp Asn Asn Ser Lys Asp Arg Thr Asn Glu Leu 
        35                  40                  45              

Ala Lys Gln Ser Gly Ala Ile Val Arg Phe Glu Pro Arg Gln Gly Lys 
    50                  55                  60                  

Gly Asn Val Val Arg Ser Met Phe Arg Glu Ile Glu Ala Asp Tyr Tyr 
65                  70                  75                  80  

Ile Met Val Asp Ala Asp Asp Thr Tyr Pro Ala Ala Glu Val Asn Lys 
                85                  90                  95      

Leu Leu Glu Pro Leu Lys Asn Gly Met Ala Asp Met Thr Ile Gly Asp 
            100                 105                 110         

Arg Leu Ser Asn Gly Thr Tyr Ser Gln Glu Asn Lys Arg Gly Phe His 
        115                 120                 125             

Asp Phe Gly Asn Asn Leu Val Lys Tyr Leu Ile Asn Lys Leu Tyr Gln 
    130                 135                 140                 

Gly His Tyr Asn Asp Ile Met Thr Gly Tyr Arg Gly Phe Asn Arg Leu 
145                 150                 155                 160 

Phe Val Lys Asn Phe Pro Val Ile Ser Pro Gly Phe Glu Ile Glu Thr 
                165                 170                 175     

Glu Met Ser Ile His Ala Leu Asp Lys Arg Phe Lys Leu Val Glu Val 
            180                 185                 190         

Pro Ile Thr Tyr Lys Asp Arg Pro Glu Gly Ser Glu Ser Lys Leu Asn 
        195                 200                 205             

Thr Phe Ser Asp Gly Phe Lys Val Leu Lys Met Ile Phe Asn Leu Phe 
    210                 215                 220                 

Lys Asp Tyr Lys Pro Leu Ile Phe Phe Ser Leu Leu Thr Val Val Met 
225                 230                 235                 240 

Phe Ile Leu Gly Leu Ile Ile Gly Ile Pro Val Ile Thr Glu Phe Ala 
                245                 250                 255     

Lys Thr Gly Met Ile Asp Lys Leu Pro Ser Ala Ile Leu Ala Thr Gly 
            260                 265                 270         

Phe Met Ile Leu Ala Ala Leu Ser Phe Val Ser Gly Phe Ile Leu Asp 
        275                 280                 285             

Thr Val Val Arg Gln Asn Arg Met Gln Tyr Glu Leu 
    290                 295                 300 

<210>   244
<211>   297
<212>   PRT
<213>   Enterococcus faecium DO

<400>   244
Lys Ile Ala Val Leu Ile Pro Cys Tyr Asn Glu Glu Ala Thr Ile Ser 
                5                   10                  15      

Thr Val Ile Ala Asp Phe Lys Arg Glu Leu Pro Glu Ala Asp Ile Tyr 
            20                  25                  30          

Val Tyr Asp Asn Asn Ser Thr Asp Arg Thr Tyr Glu Leu Ala Val Gln 
        35                  40                  45              

Gly Gly Ala Ile Val Lys Lys Glu Pro Arg Gln Gly Lys Gly Asn Val 
    50                  55                  60                  

Ile Arg Gln Met Phe Phe Asp Ile Asp Ala Asp Tyr Tyr Leu Met Val 
65                  70                  75                  80  

Asp Gly Asp Asp Thr Tyr Pro Ala Glu Ala Val His Gly Leu Leu Glu 
                85                  90                  95      

Lys Leu Arg Ser Gly Glu Ala Asp Met Val Ile Gly Asp Arg Leu Ser 
            100                 105                 110         

Asn Gly Thr Tyr Phe Asp Glu Asn Lys Arg Pro Phe His Asp Phe Gly 
        115                 120                 125             

Asn Asn Leu Val Arg Asn Thr Ile Thr Arg Met Tyr Lys Thr Lys Ile 
    130                 135                 140                 

Leu Asp Val Met Thr Gly Tyr Arg Gly Phe Asn Arg Ile Phe Val Lys 
145                 150                 155                 160 

Ser Phe Pro Ile Met Ser Ser Gly Phe Gln Ile Glu Thr Glu Leu Thr 
                165                 170                 175     

Ile His Ala Leu Asp Lys Lys Phe Lys Phe Val Glu Ile Pro Ile Asp 
            180                 185                 190         

Tyr Arg Asp Arg Pro Glu Gly Ser Glu Ser Lys Leu Asn Thr Phe Ser 
        195                 200                 205             

Asp Gly Phe Lys Val Ile Met Met Ile Ile Lys Met Phe Lys Asp Tyr 
    210                 215                 220                 

Lys Pro Leu Leu Phe Phe Gly Ile Trp Thr Ile Phe Phe Phe Leu Phe 
225                 230                 235                 240 

Gly Leu Val Thr Gly Ile Pro Val Ile Arg Glu Tyr Met Leu Thr Ser 
                245                 250                 255     

Phe Ile Thr Arg Ile Pro Ser Ala Ile Leu Ser Thr Gly Leu Met Thr 
            260                 265                 270         

Leu Ala Leu Leu Ser Leu Val Thr Gly Leu Ile Leu Asp Thr Val Val 
        275                 280                 285             

Thr Asn Ala Lys Lys Glu Tyr Glu Leu 
    290                 295         

<210>   245
<211>   297
<212>   PRT
<213>   Listeria monocytogenes str. 4b F2365

<400>   245
Lys Val Ala Val Leu Leu Pro Cys Tyr Asn Glu Glu Leu Thr Ile Gly 
                5                   10                  15      

Lys Val Ile Asp Asp Phe Lys Lys Glu Leu Pro Asn Ala Asp Ile Tyr 
            20                  25                  30          

Val Tyr Asp Asn Asn Ser Lys Asp Lys Thr Phe Glu Ile Ala Lys Asp 
        35                  40                  45              

His Gly Ala Ile Val Arg Lys Glu Met Arg Gln Gly Lys Gly Asn Val 
    50                  55                  60                  

Val Arg Ser Met Phe Ala Asp Ile Asp Ala Asp Tyr Tyr Leu Met Val 
65                  70                  75                  80  

Asp Gly Asp Asp Thr Tyr Pro Ala Glu Tyr Cys His Glu Ile Leu Glu 
                85                  90                  95      

Val Leu Arg Asn Lys Glu Ala Asn Met Val Ile Gly Asp Arg Leu Ser 
            100                 105                 110         

Asn Gly Thr Tyr Thr Glu Glu Asn Lys Arg Asn Phe His Asp Phe Gly 
        115                 120                 125             

Asn Ser Leu Val Arg Asn Thr Ile Asn Arg Ile Phe Lys Ser Asn Leu 
    130                 135                 140                 

Arg Asp Ile Met Thr Gly Tyr Arg Gly Phe Asp Arg Tyr Phe Val Lys 
145                 150                 155                 160 

Thr Met Pro Val Leu Ser Pro Gly Phe Glu Ile Glu Thr Glu Met Ser 
                165                 170                 175     

Ile His Ala Leu Glu Asn Arg Phe Leu Val Lys Glu Ile Glu Ile Asp 
            180                 185                 190         

Tyr Arg Asp Arg Pro Glu Gly Ser Glu Ser Lys Leu Asn Thr Phe Ser 
        195                 200                 205             

Asp Gly Phe Lys Val Ile Met Thr Ile Val Arg Leu Phe Lys Asn Ser 
    210                 215                 220                 

Arg Pro Phe Leu Phe Phe Asn Leu Leu Ala Ser Leu Phe Val Leu Val 
225                 230                 235                 240 

Gly Val Leu Val Gly Leu Pro Val Ile Ile Gln Phe Ala Gln Ile Gly 
                245                 250                 255     

Leu Val Leu Lys Phe Pro Ser Ala Leu Leu Ala Thr Gly Leu Ile Ile 
            260                 265                 270         

Met Gly Met Leu Phe Phe Ile Cys Gly Leu Ile Leu Asp Thr Ile Ala 
        275                 280                 285             

His Arg Ser Arg Gln Ser Tyr Phe Leu 
    290                 295         

<210>   246
<211>   307
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 239

<400>   246
Met Thr Met Arg Ile Ala Val Leu Ile Pro Cys Tyr Asn Glu Glu Leu 
                5                   10                  15      

Thr Ile Gly Lys Val Val Gln Asp Phe Arg Arg Glu Leu Pro Asp Ala 
            20                  25                  30          

Glu Ile Tyr Val Tyr Asp Asn Asn Ser Arg Asp Arg Thr Ala Glu Val 
        35                  40                  45              

Ala Arg Glu Ala Gly Ala Ile Val Arg Arg Glu Thr Arg Gln Gly Lys 
    50                  55                  60                  

Gly Asn Val Val Arg Ser Met Phe Arg Asp Ile Asp Ala Asp Val Tyr 
65                  70                  75                  80  

Val Met Thr Asp Gly Asp Asp Thr Tyr Pro Ala Glu Phe Val His Asp 
                85                  90                  95      

Leu Ile Arg Pro Ile Ile Glu Gly Glu Ala Asp Met Cys Ile Gly Asp 
            100                 105                 110         

Arg His Ser Asp Gly Ser Tyr Ser Lys Glu Asn Lys Arg Pro Phe His 
        115                 120                 125             

Asn Phe Gly Asn Gln Leu Val Arg Lys Leu Ile Asn Thr Leu Phe His 
    130                 135                 140                 

Ala Asp Leu Arg Asp Ile Met Thr Gly Tyr Arg Ala Phe Ser Arg Arg 
145                 150                 155                 160 

Phe Ala Lys Thr Met Pro Ile Gln Ser Glu Gly Phe Glu Ile Glu Thr 
                165                 170                 175     

Glu Met Thr Leu His Ala Leu Asp Lys Arg Phe Arg Ile Leu Glu Ile 
            180                 185                 190         

Pro Ile Gln Tyr Arg Asp Arg Pro Pro Gly Ser His Ser Lys Leu Asn 
        195                 200                 205             

Thr Leu Ser Asp Gly Ile Arg Val Leu Lys Thr Val Phe Trp Ile Phe 
    210                 215                 220                 

Lys Asp Tyr Lys Pro Leu Ala Phe Phe Thr Ala Val Ala Leu Ile Leu 
225                 230                 235                 240 

Phe Leu Ala Gly Leu Gly Val Gly Ile Pro Val Leu Tyr Glu Tyr Phe 
                245                 250                 255     

Ser Phe Gly Arg Ile Ala Lys Ile Pro Ser Ala Ile Leu Ala Val Gly 
            260                 265                 270         

Phe Met Ile Leu Ala Thr Asn Ser Leu Thr Cys Gly Phe Ile Leu Asp 
        275                 280                 285             

Thr Ile Val Arg His His Arg Asp Tyr Tyr Glu Leu Leu Gln Asn Glu 
    290                 295                 300                 

Phe Lys Gly 
305         

<210>   247
<211>   307
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 239

<400>   247
Met Thr Met Arg Ile Ala Val Leu Ile Pro Cys Tyr Asn Glu Glu Leu 
                5                   10                  15      

Thr Ile Gly Lys Val Val Gln Asp Phe Arg Arg Glu Leu Pro Asp Ala 
            20                  25                  30          

Glu Ile Tyr Val Tyr Asp Asn Asn Ser Arg Asp Arg Thr Ala Glu Val 
        35                  40                  45              

Ala Arg Glu Ala Gly Ala Ile Val Arg Arg Glu Thr Arg Gln Gly Lys 
    50                  55                  60                  

Gly Asn Val Val Arg Ser Met Phe Arg Asp Ile Asp Ala Asp Val Tyr 
65                  70                  75                  80  

Val Met Thr Asp Gly Asp Asp Thr Tyr Pro Ala Glu Phe Val His Asp 
                85                  90                  95      

Leu Ile Arg Pro Ile Ile Glu Gly Glu Ala Asp Met Cys Ile Gly Asp 
            100                 105                 110         

Arg His Ser Asp Gly Ser Tyr Ser Lys Glu Asn Lys Arg Pro Phe His 
        115                 120                 125             

Asn Phe Gly Asn Gln Leu Val Arg Lys Leu Ile Asn Thr Leu Phe His 
    130                 135                 140                 

Ala Asp Ile Arg Asp Ile Met Thr Gly Tyr Arg Ala Phe Ser Arg Arg 
145                 150                 155                 160 

Phe Ala Lys Thr Met Pro Ile Gln Ser Glu Gly Phe Glu Ile Glu Thr 
                165                 170                 175     

Glu Met Thr Leu His Ala Leu Asp Lys Arg Phe Arg Ile Leu Glu Ile 
            180                 185                 190         

Pro Ile Gln Tyr Arg Asp Arg Pro Pro Gly Ser His Ser Lys Leu Asn 
        195                 200                 205             

Thr Leu Ser Asp Gly Ile Arg Val Leu Lys Thr Val Phe Trp Ile Phe 
    210                 215                 220                 

Lys Asp Tyr Lys Pro Leu Ala Phe Phe Thr Ala Val Ala Leu Ile Leu 
225                 230                 235                 240 

Phe Leu Ala Gly Leu Gly Val Gly Ile Pro Val Leu Tyr Glu Tyr Phe 
                245                 250                 255     

Ser Phe Gly Arg Ile Ala Lys Ile Pro Ser Ala Ile Leu Ala Val Gly 
            260                 265                 270         

Phe Met Val Leu Ala Thr Asn Ser Leu Thr Cys Gly Phe Ile Leu Asp 
        275                 280                 285             

Thr Ile Val Arg His His Arg Asp Tyr Tyr Glu Leu Leu Gln Asn Glu 
    290                 295                 300                 

Phe Lys Gly 
305         

<210>   248
<211>   307
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 239

<400>   248
Met Thr Met Arg Ile Ala Val Leu Ile Pro Cys Tyr Asn Glu Glu Leu 
                5                   10                  15      

Thr Ile Gly Lys Val Val Asn Asp Phe Arg Arg Glu Leu Pro Asp Ala 
            20                  25                  30          

Glu Ile Tyr Val Tyr Asp Asn Asn Ser Arg Asp Arg Thr Ala Glu Val 
        35                  40                  45              

Ala Arg Glu Ala Gly Ala Ile Val Arg Arg Glu Thr Arg Gln Gly Lys 
    50                  55                  60                  

Gly Asn Val Val Arg Ser Met Phe Arg Asp Ile Asp Ala Asp Val Tyr 
65                  70                  75                  80  

Val Met Thr Asp Gly Asp Asp Thr Tyr Pro Ala Glu Phe Val His Asp 
                85                  90                  95      

Leu Ile Arg Pro Ile Ile Glu Gly Glu Ala Asp Met Cys Ile Gly Asp 
            100                 105                 110         

Arg His Ser Asp Gly Ser Tyr Ser Lys Glu Asn Lys Arg Pro Phe His 
        115                 120                 125             

Asn Phe Gly Asn Gln Leu Val Arg Lys Leu Ile Asn Thr Leu Phe His 
    130                 135                 140                 

Ala Asp Leu Arg Asp Ile Met Thr Gly Tyr Arg Ala Phe Ser Arg Arg 
145                 150                 155                 160 

Phe Ala Lys Thr Met Pro Ile Gln Ser Glu Gly Phe Glu Ile Glu Thr 
                165                 170                 175     

Glu Met Thr Leu His Ala Leu Asp Lys Arg Phe Arg Ile Leu Glu Ile 
            180                 185                 190         

Pro Ile Gln Tyr Arg Asp Arg Pro Pro Gly Ser His Ser Lys Leu Asn 
        195                 200                 205             

Thr Leu Ser Asp Gly Ile Arg Val Leu Lys Thr Val Phe Trp Ile Phe 
    210                 215                 220                 

Lys Asp Tyr Lys Pro Leu Ala Phe Phe Thr Ala Val Ala Leu Ile Leu 
225                 230                 235                 240 

Phe Leu Ala Gly Leu Gly Val Gly Ile Pro Val Leu Tyr Glu Tyr Phe 
                245                 250                 255     

Ser Phe Gly Arg Ile Ala Lys Ile Pro Ser Ala Ile Leu Ala Val Gly 
            260                 265                 270         

Phe Met Val Leu Ala Thr Asn Ser Leu Thr Cys Gly Phe Ile Leu Asp 
        275                 280                 285             

Thr Ile Val Arg His His Arg Asp Tyr Tyr Glu Leu Leu Gln Asn Glu 
    290                 295                 300                 

Phe Lys Gly 
305         

<210>   249
<211>   307
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 239

<400>   249
Met Thr Met Arg Ile Ala Val Leu Ile Pro Cys Tyr Asn Glu Glu Leu 
                5                   10                  15      

Thr Ile Gly Lys Val Val Gln Asp Phe Arg Arg Glu Leu Pro Asp Ala 
            20                  25                  30          

Glu Ile Tyr Val Tyr Asp Asn Asn Ser Arg Asp Arg Thr Ala Glu Val 
        35                  40                  45              

Ala Arg Glu Ala Gly Ala Ile Val Arg Arg Glu Thr Arg Gln Gly Lys 
    50                  55                  60                  

Gly Asn Val Val Arg Ser Met Phe Arg Asp Ile Asp Ala Asp Val Tyr 
65                  70                  75                  80  

Val Met Thr Asp Gly Asp Asp Thr Tyr Pro Ala Glu Phe Val His Asp 
                85                  90                  95      

Leu Ile Arg Pro Ile Ile Glu Gly Glu Ala Asp Met Cys Ile Gly Asp 
            100                 105                 110         

Arg His Ser Asp Gly Ser Tyr Ser Lys Glu Asn Lys Arg Pro Phe His 
        115                 120                 125             

Asn Phe Gly Asn Gln Leu Val Arg Lys Leu Ile Asn Thr Leu Phe His 
    130                 135                 140                 

Ala Asp Leu Lys Asp Ile Met Thr Gly Tyr Arg Ala Phe Ser Arg Arg 
145                 150                 155                 160 

Phe Ala Lys Thr Met Pro Ile Gln Ser Glu Gly Phe Glu Ile Glu Thr 
                165                 170                 175     

Glu Met Thr Leu His Ala Leu Asp Lys Arg Phe Arg Ile Leu Glu Ile 
            180                 185                 190         

Pro Ile Gln Tyr Arg Asp Arg Pro Pro Gly Ser His Ser Lys Leu Asn 
        195                 200                 205             

Thr Leu Ser Asp Gly Ile Arg Val Leu Lys Thr Val Phe Trp Ile Phe 
    210                 215                 220                 

Lys Asp Tyr Lys Pro Leu Ala Phe Phe Thr Ala Val Ala Leu Ile Leu 
225                 230                 235                 240 

Phe Leu Ala Gly Leu Gly Val Gly Ile Pro Val Leu Tyr Glu Tyr Phe 
                245                 250                 255     

Ser Phe Gly Arg Ile Ala Lys Ile Pro Ser Ala Ile Leu Ala Val Gly 
            260                 265                 270         

Phe Met Val Leu Ala Thr Asn Ser Leu Thr Cys Gly Phe Ile Leu Asp 
        275                 280                 285             

Thr Ile Val Arg His His Arg Asp Tyr Tyr Glu Leu Leu Gln Asn Glu 
    290                 295                 300                 

Phe Lys Gly 
305         

<210>   250
<211>   307
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 239

<400>   250
Met Thr Met Arg Ile Ala Val Leu Ile Pro Cys Tyr Asn Glu Glu Leu 
                5                   10                  15      

Thr Ile Gly Lys Val Val Gln Asp Phe Arg Arg Glu Leu Pro Asp Ala 
            20                  25                  30          

Glu Ile Tyr Val Tyr Asp Asn Asn Ser Arg Asp Arg Thr Ala Glu Val 
        35                  40                  45              

Ala Arg Glu Ala Gly Ala Ile Val Arg Arg Glu Thr Arg Gln Gly Lys 
    50                  55                  60                  

Gly Asn Val Val Arg Ser Met Phe Arg Asp Ile Asp Ala Asp Val Tyr 
65                  70                  75                  80  

Val Met Thr Asp Gly Asp Asp Thr Tyr Pro Ala Glu Phe Val His Asp 
                85                  90                  95      

Leu Ile Arg Pro Ile Ile Glu Gly Glu Ala Asp Met Cys Ile Gly Asp 
            100                 105                 110         

Arg His Ser Asp Gly Ser Tyr Ser Lys Glu Asn Lys Arg Pro Phe His 
        115                 120                 125             

Asn Phe Gly Asn Gln Leu Val Arg Lys Leu Ile Asn Thr Leu Phe His 
    130                 135                 140                 

Ala Asp Leu Arg Asp Ile Met Thr Gly Tyr Arg Ala Phe Ser Arg Arg 
145                 150                 155                 160 

Phe Ala Lys Thr Met Pro Ile Gln Ser Glu Gly Phe Glu Ile Glu Thr 
                165                 170                 175     

Glu Met Thr Leu His Ala Leu Asp Lys Arg Phe Arg Ile Leu Glu Ile 
            180                 185                 190         

Pro Ile Gln Tyr Arg Asp Arg Pro Pro Gly Ser His Ser Lys Leu Asn 
        195                 200                 205             

Thr Leu Ser Asp Gly Ile Arg Val Leu Lys Thr Val Phe Trp Ile Phe 
    210                 215                 220                 

Lys Asp Tyr Lys Pro Leu Ala Phe Phe Thr Ala Val Ala Leu Ile Leu 
225                 230                 235                 240 

Phe Leu Ala Gly Leu Gly Val Gly Leu Pro Val Leu Tyr Glu Tyr Phe 
                245                 250                 255     

Ser Phe Gly Arg Ile Ala Lys Ile Pro Ser Ala Ile Leu Ala Val Gly 
            260                 265                 270         

Phe Met Val Leu Ala Thr Asn Ser Leu Thr Cys Gly Phe Ile Leu Asp 
        275                 280                 285             

Thr Ile Val Arg His His Arg Asp Tyr Tyr Glu Leu Leu Gln Asn Glu 
    290                 295                 300                 

Phe Lys Gly 
305         

<210>   251
<211>   924
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 240

<400>   251
gtgaccatgc gaatcgcagt cctcatcccg tgttacaacg aagaactgac cattggaaaa       60

gtggttcagg actttaggcg cgaactgccc gacgcggaga tttacgtgta cgacaacaac      120

tcgcgcgatc gcaccgcgga agtggcgagg gaagcgggcg cgattgtgcg aagagagact      180

cgtcagggca agggaaacgt ggtgcgctcg atgttccgcg acatcgacgc cgacgtgtac      240

gtcatgaccg acggagacga cacgtacccg gcggaattcg tgcacgatct cattcggccg      300

atcatcgaag gagaggccga catgtgcatc ggcgaccgtc actccgacgg ctcgtactcc      360

aaggagaaca agcgcccttt ccacaacttc ggcaaccagt tggtgcggaa gctgatcaac      420

accctgtttc acgcagatct ccgggacatc atgaccggct accgggcgtt cagccgccgc      480

ttcgccaaga ccatgcccat ccagagcgag ggctttgaaa tcgagacgga aatgacgctc      540

cacgcgctgg acaagcgctt ccgcatcctc gaaatcccga tccaataccg ggatcggccg      600

ccgggcagcc actccaagtt gaacacgctg agcgacggca tccgggtgtt gaagaccgtc      660

ttttggattt tcaaagacta caagccgctc gctttcttca ccgccgtcgc cttgatcctg      720

tttttggccg gcctcggcgt cggcattccc gtgttgtacg agtacttctc gtttggccgc      780

atcgcgaaga tcccgtccgc catcctcgcg gtcggattca tgattctggc gaccaacagc      840

ctgacgtgcg gctttattct ggacaccatc gtccgccatc accgcgacta ctacgagctc      900

ttgcagaacg aatttaaagg ctga                                             924


<210>   252
<211>   924
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 240

<400>   252
gtgaccatgc gaatcgcagt cctcatcccg tgttacaacg aagaactgac cattggaaaa       60

gtggttcagg actttaggcg cgaactgccc gacgcggaga tttacgtgta cgacaacaac      120

tcgcgcgatc gcaccgcgga agtggcgagg gaagcgggcg cgattgtgcg aagagagact      180

cgtcagggca agggaaacgt ggtgcgctcg atgttccgcg acatcgacgc cgacgtgtac      240

gtcatgaccg acggagacga cacgtacccg gcggaattcg tgcacgatct cattcggccg      300

atcatcgaag gagaggccga catgtgcatc ggcgaccgtc actccgacgg ctcgtactcc      360

aaggagaaca agcgcccttt ccacaacttc ggcaaccagt tggtgcggaa gctgatcaac      420

accctgtttc acgcagatat tcgggacatc atgaccggct accgggcgtt cagccgccgc      480

ttcgccaaga ccatgcccat ccagagcgag ggctttgaaa tcgagacgga aatgacgctc      540

cacgcgctgg acaagcgctt ccgcatcctc gaaatcccga tccaataccg ggatcggccg      600

ccgggcagcc actccaagtt gaacacgctg agcgacggca tccgggtgtt gaagaccgtc      660

ttttggattt tcaaagacta caagccgctc gctttcttca ccgccgtcgc cttgatcctg      720

tttttggccg gcctcggcgt cggcattccc gtgttgtacg agtacttctc gtttggccgc      780

atcgcgaaga tcccgtccgc catcctcgcg gtcggattca tggtgctggc gaccaacagc      840

ctgacgtgcg gctttattct ggacaccatc gtccgccatc accgcgacta ctacgagctc      900

ttgcagaacg aatttaaagg ctga                                             924


<210>   253
<211>   924
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 240

<400>   253
gtgaccatgc gaatcgcagt cctcatcccg tgttacaacg aagaactgac cattggaaaa       60

gtggttaatg actttaggcg cgaactgccc gacgcggaga tttacgtgta cgacaacaac      120

tcgcgcgatc gcaccgcgga agtggcgagg gaagcgggcg cgattgtgcg aagagagact      180

cgtcagggca agggaaacgt ggtgcgctcg atgttccgcg acatcgacgc cgacgtgtac      240

gtcatgaccg acggagacga cacgtacccg gcggaattcg tgcacgatct cattcggccg      300

atcatcgaag gagaggccga catgtgcatc ggcgaccgtc actccgacgg ctcgtactcc      360

aaggagaaca agcgcccttt ccacaacttc ggcaaccagt tggtgcggaa gctgatcaac      420

accctgtttc acgcagatct ccgggacatc atgaccggct accgggcgtt cagccgccgc      480

ttcgccaaga ccatgcccat ccagagcgag ggctttgaaa tcgagacgga aatgacgctc      540

cacgcgctgg acaagcgctt ccgcatcctc gaaatcccga tccaataccg ggatcggccg      600

ccgggcagcc actccaagtt gaacacgctg agcgacggca tccgggtgtt gaagaccgtc      660

ttttggattt tcaaagacta caagccgctc gctttcttca ccgccgtcgc cttgatcctg      720

tttttggccg gcctcggcgt cggcattccc gtgttgtacg agtacttctc gtttggccgc      780

atcgcgaaga tcccgtccgc catcctcgcg gtcggattca tggtgctggc gaccaacagc      840

ctgacgtgcg gctttattct ggacaccatc gtccgccatc accgcgacta ctacgagctc      900

ttgcagaacg aatttaaagg ctga                                             924


<210>   254
<211>   924
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 240

<400>   254
gtgaccatgc gaatcgcagt cctcatcccg tgttacaacg aagaactgac cattggaaaa       60

gtggttcagg actttaggcg cgaactgccc gacgcggaga tttacgtgta cgacaacaac      120

tcgcgcgatc gcaccgcgga agtggcgagg gaagcgggcg cgattgtgcg aagagagact      180

cgtcagggca agggaaacgt ggtgcgctcg atgttccgcg acatcgacgc cgacgtgtac      240

gtcatgaccg acggagacga cacgtacccg gcggaattcg tgcacgatct cattcggccg      300

atcatcgaag gagaggccga catgtgcatc ggcgaccgtc actccgacgg ctcgtactcc      360

aaggagaaca agcgcccttt ccacaacttc ggcaaccagt tggtgcggaa gctgatcaac      420

accctgtttc acgcagatct caaagacatc atgaccggct accgggcgtt cagccgccgc      480

ttcgccaaga ccatgcccat ccagagcgag ggctttgaaa tcgagacgga aatgacgctc      540

cacgcgctgg acaagcgctt ccgcatcctc gaaatcccga tccaataccg ggatcggccg      600

ccgggcagcc actccaagtt gaacacgctg agcgacggca tccgggtgtt gaagaccgtc      660

ttttggattt tcaaagacta caagccgctc gctttcttca ccgccgtcgc cttgatcctg      720

tttttggccg gcctcggcgt cggcattccc gtgttgtacg agtacttctc gtttggccgc      780

atcgcgaaga tcccgtccgc catcctcgcg gtcggattca tggtgctggc gaccaacagc      840

ctgacgtgcg gctttattct ggacaccatc gtccgccatc accgcgacta ctacgagctc      900

ttgcagaacg aatttaaagg ctga                                             924


<210>   255
<211>   924
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 240

<400>   255
gtgaccatgc gaatcgcagt cctcatcccg tgttacaacg aagaactgac cattggaaaa       60

gtggttcagg actttaggcg cgaactgccc gacgcggaga tttacgtgta cgacaacaac      120

tcgcgcgatc gcaccgcgga agtggcgagg gaagcgggcg cgattgtgcg aagagagact      180

cgtcagggca agggaaacgt ggtgcgctcg atgttccgcg acatcgacgc cgacgtgtac      240

gtcatgaccg acggagacga cacgtacccg gcggaattcg tgcacgatct cattcggccg      300

atcatcgaag gagaggccga catgtgcatc ggcgaccgtc actccgacgg ctcgtactcc      360

aaggagaaca agcgcccttt ccacaacttc ggcaaccagt tggtgcggaa gctgatcaac      420

accctgtttc acgcagatct ccgggacatc atgaccggct accgggcgtt cagccgccgc      480

ttcgccaaga ccatgcccat ccagagcgag ggctttgaaa tcgagacgga aatgacgctc      540

cacgcgctgg acaagcgctt ccgcatcctc gaaatcccga tccaataccg ggatcggccg      600

ccgggcagcc actccaagtt gaacacgctg agcgacggca tccgggtgtt gaagaccgtc      660

ttttggattt tcaaagacta caagccgctc gctttcttca ccgccgtcgc cttgatcctg      720

tttttggccg gcctcggcgt cggcttaccc gtgttgtacg agtacttctc gtttggccgc      780

atcgcgaaga tcccgtccgc catcctcgcg gtcggattca tggtgctggc gaccaacagc      840

ctgacgtgcg gctttattct ggacaccatc gtccgccatc accgcgacta ctacgagctc      900

ttgcagaacg aatttaaagg ctga                                             924


<210>   256
<211>   408
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   256
Met Arg Gly Ser Ala Met Met Asp Arg Ala Lys Pro Arg Ile Gly Arg 
                5                   10                  15      

Pro Trp Arg Lys Glu Ala Leu Cys Val Asp Val Ser Val Val Ile Pro 
            20                  25                  30          

Thr Tyr Asn Glu Arg Asp Asn Ile His Pro Leu Val Glu Arg Ile His 
        35                  40                  45              

Gln Ala Leu Ala Pro Leu Gly Ile Ser Tyr Glu Ile Trp Phe Val Asp 
    50                  55                  60                  

Asp Ser Ser Asp Asp Thr Val Ala Val Leu Arg Asp Leu Glu Ala Arg 
65                  70                  75                  80  

Asp Pro Ala Val His Val Phe His Arg Asp His Glu Arg Gly Leu Ala 
                85                  90                  95      

Ser Ala Val Val Arg Gly Phe Glu Lys Ala Gln Gly Arg Tyr Leu Val 
            100                 105                 110         

Val Met Asp Ala Asp Leu Gln His Pro Pro Glu Leu Leu Pro Ala Ile 
        115                 120                 125             

Tyr Glu Arg Leu Glu Ser Gly Ile Asp Val Val Ile Pro Ser Arg Phe 
    130                 135                 140                 

Val Glu Gly Gly Ser Asp Gly Gly Leu Gly Pro Leu Arg Lys Leu Ile 
145                 150                 155                 160 

Ser Trp Thr Ala Arg Val Ile Gly Gln Leu Ala Leu His Arg Leu Arg 
                165                 170                 175     

Lys Ile Ser Asp Cys Thr Ser Gly Phe Phe Gly Leu Arg Arg Glu Val 
            180                 185                 190         

Ile Glu Gly Val Glu Leu Asn Pro Ile Gly Trp Lys Ile Leu Ile Glu 
        195                 200                 205             

Val Leu Val Lys Gly Arg Tyr Arg Ser Val His Glu Ile Ala Tyr Glu 
    210                 215                 220                 

Phe Val Ala Arg Asp Phe Gly Glu Ser Lys Met Ser Leu Lys Glu Gln 
225                 230                 235                 240 

Trp Asn Tyr Phe Arg His Leu Val Arg Leu Val Ser Gln Ser Pro Pro 
                245                 250                 255     

Asp Arg Arg Phe Phe Leu Phe Cys Leu Ile Gly Leu Ser Gly Val Val 
            260                 265                 270         

Val Asn Glu Ala Val Leu Ser Leu Leu Trp Tyr Gly Phe His Leu Arg 
        275                 280                 285             

Asp Thr Val Ala Ser Val Ala Ala Ser Phe Val Ala Met Leu Asn Asn 
    290                 295                 300                 

Tyr Phe Trp Asn Asp Arg Val Thr Trp Lys Ser Glu Ser Ser Gly Arg 
305                 310                 315                 320 

Gly Trp Gly Trp Lys Leu Pro Val Phe Val Gly Ile Ser Val Val Gly 
                325                 330                 335     

Ile Ala Ile Thr Thr Leu Val Met Arg Gly Cys Glu Gly Phe Gly Val 
            340                 345                 350         

Pro Val Pro Ala Gly Gln Ala Ile Gly Ile Leu Val Ser Thr Ala Trp 
        355                 360                 365             

Ser Tyr Trp Met Asn Ser Arg Val Thr Trp Arg Asn Ile Glu Arg Glu 
    370                 375                 380                 

Ala Arg Gly Asp Ala Ile Val Val Thr Arg Glu Ser Val Arg Asp Ser 
385                 390                 395                 400 

Leu Met Arg Ala Lys Thr Gly Ala 
                405             

<210>   257
<211>   1227
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   257
gtgcgtggtt ccgcgatgat ggacagggcc aagcctcgga tcggtaggcc ttggcgcaag       60

gaggctttgt gcgtggacgt cagtgtggtg atcccgactt acaacgagcg agacaacatc      120

catcccctgg tggagcgcat ccatcaagct ttagcccctc tggggatttc ctacgagatc      180

tggtttgtcg atgacagcag cgacgatacg gtcgcagtgc ttcgagatct ggaggcccgg      240

gatcccgccg ttcacgtgtt ccaccgcgat cacgagcgtg gcctcgcgag cgcggtcgtg      300

cgtggattcg aaaaggcgca gggcaggtac cttgtcgtga tggacgctga cctgcagcat      360

ccgccggagc tgttgccggc catctacgag cgtttggagt ccgggatcga cgtggtaatc      420

ccaagccgtt tcgtggaagg gggctcggac ggcgggttgg gcccgctgcg aaagctcatc      480

tcgtggaccg cgcgggtcat tgggcaactc gcgctccatc gcctgcgcaa gatctcggat      540

tgcacgagcg gtttctttgg cctgcggcgc gaagtgattg aaggcgtcga actgaacccc      600

attggatgga agatcttgat cgaggtgctg gtgaaaggcc gctatcgcag cgtgcatgag      660

atcgcgtacg agttcgtggc ccgcgacttc ggcgaatcga agatgagcct caaggagcag      720

tggaactact ttcgccacct cgtgcgcctg gtgagccaga gcccgccgga tcggcggttc      780

tttctgttct gcctcatcgg cctgtcgggc gtggtggtga acgaggcagt cctgagcctc      840

ctgtggtacg ggttccacct gcgggacacc gtggcttccg tcgccgcttc tttcgtggcc      900

atgttgaaca actatttttg gaacgatcgc gtcacgtgga aatccgagtc ctccggacga      960

gggtggggat ggaagctgcc cgtgttcgtc ggcatttcgg tcgtcgggat cgccatcacg     1020

acgctcgtga tgcgaggatg cgagggcttt ggcgtgcccg ttcccgctgg acaggccatc     1080

ggcatcctgg tgtccacagc gtggtcgtat tggatgaaca gccgcgtgac ttggcgaaac     1140

atcgagcgcg aagcgcgtgg ggatgcgatt gtggtcacac gggagtcggt gcgggattcg     1200

ctgatgcggg cgaaaacagg cgcgtga                                         1227


<210>   258
<211>   376
<212>   PRT
<213>   Syntrophomonas wolfei subsp. wolfei str. Goettingen

<400>   258
Leu Ser Ile Ile Ile Pro Thr Tyr Asn Glu Arg Asp Asn Val Leu Arg 
                5                   10                  15      

Ile Ala Glu His Ile Gly Asn Thr Leu Lys Asn Ser Tyr Glu Ile Val 
            20                  25                  30          

Phe Val Asp Asp Ser Asn Asp Asp Thr Pro Glu Ile Leu Gln Tyr Leu 
        35                  40                  45              

Ser Lys Ser Asp Pro His Leu Arg Phe Glu His Arg His Lys Glu Arg 
    50                  55                  60                  

Gly Leu Gly Thr Ala Val Val Arg Gly Phe Glu Ile Ala Ser Gly Asp 
65                  70                  75                  80  

Val Ile Ala Val Met Asp Ala Asp Leu Gln His Pro Pro Glu Val Leu 
                85                  90                  95      

Leu Ser Met Leu Lys Ala Ile Glu Ser Gly Ala Asp Ile Val Ile Pro 
            100                 105                 110         

Ser Arg Phe Ile Pro Gly Gly Asn Asp Gly Gly Leu Lys Leu His Arg 
        115                 120                 125             

Lys Ile Val Ser Ala Thr Ala Arg Tyr Ile Gly Lys Ala Leu Ile Lys 
    130                 135                 140                 

Lys Leu Arg Pro Ile Ser Asp Ser Thr Ser Gly Phe Phe Met Phe Arg 
145                 150                 155                 160 

Lys Asp Val Ile Lys Glu Ala Glu Leu Gln Pro Ile Gly Trp Lys Ile 
                165                 170                 175     

Leu Ile Glu Val Leu Ala Arg Gly Lys Tyr Thr Arg Val Ile Glu Ile 
            180                 185                 190         

Pro Tyr Gln Phe Gln Ala Arg Thr Ala Gly Glu Ser Lys Met Ser Ala 
        195                 200                 205             

Gln Glu Gln Trp Asn Tyr Ile Arg His Leu Met Arg Leu Val Lys Asp 
    210                 215                 220                 

Ser Pro Glu Asp Arg Arg Phe Phe Tyr Phe Ser Leu Val Gly Leu Ser 
225                 230                 235                 240 

Gly Val Phe Val Asn Met Leu Ile Tyr Phe Phe Leu Thr Met Leu Asn 
                245                 250                 255     

Leu Glu Val Arg Ile Ala Gly Phe Cys Ser Ala Phe Val Ala Met Leu 
            260                 265                 270         

Val Asn Phe Val Leu Asn Asp Lys Ile Thr Trp Ala Tyr Val Lys Thr 
        275                 280                 285             

Asn Ser Val Trp Ser Arg Gly Ser Lys Tyr Ile Ile Thr Ser Leu Ile 
    290                 295                 300                 

Gly Ile Gly Ile Asn Val Gly Val Leu Asp Phe Phe Tyr Tyr Gln Leu 
305                 310                 315                 320 

Gln Phe Asn His Leu Leu Ser Asn Leu Ile Gly Ile Ser Cys Ala Val 
                325                 330                 335     

Phe Trp Asn Tyr Thr Ile Asn Asn Leu Trp Thr Trp Ser Thr Ala Lys 
            340                 345                 350         

His Asn Asn Thr Ile Ile Glu Arg Trp Thr Val Gln Asn Gly Cys Glu 
        355                 360                 365             

Ser Ser Val Glu Lys Thr Gly Ser 
    370                 375     

<210>   259
<211>   349
<212>   PRT
<213>   Thermococcus kodakarensis KOD1

<400>   259
Ile Ser Val Val Ile Pro Thr Tyr Asn Glu Arg Glu Asn Leu Pro Glu 
                5                   10                  15      

Leu Val Glu Arg Leu Ser Arg Ala Leu Gln Gly Tyr Glu Tyr Glu Ile 
            20                  25                  30          

Val Ile Val Asp Asp Asp Ser Pro Asp Lys Thr Trp Gly Leu Ala Glu 
        35                  40                  45              

Glu Leu Ala Arg Lys Tyr Pro Ile Lys Val Ile Arg Arg Thr Lys Glu 
    50                  55                  60                  

Lys Gly Leu Ser Ser Ala Val Ile Arg Gly Phe Lys Glu Ala Ser Gly 
65                  70                  75                  80  

Asp Val Phe Val Val Met Asp Ala Asp Leu Gln His Pro Pro Glu Lys 
                85                  90                  95      

Val Pro Glu Leu Ile Glu Ala Ile Lys Arg Gly Ala Asp Ile Ala Ile 
            100                 105                 110         

Ala Ser Arg Tyr Val Pro Gly Gly Ala Val Lys Asn Trp Tyr Trp Tyr 
        115                 120                 125             

Arg Lys Leu Ile Ser Lys Gly Ala Ile Met Ile Gly Arg Val Ala Leu 
    130                 135                 140                 

Pro Arg Ile Arg Asn Val Lys Asp Pro Val Ser Gly Phe Phe Ala Leu 
145                 150                 155                 160 

Arg Arg Glu Val Val Glu Gly Val Glu Leu Asn Pro Val Gly Phe Lys 
                165                 170                 175     

Ile Leu Met Glu Ile Leu Val Lys Gly His Tyr Asn Asn Val Arg Glu 
            180                 185                 190         

Val Pro Phe Thr Phe Gly Leu Arg Lys Ala Gly Glu Ser Lys Leu Gly 
        195                 200                 205             

Ser Arg Thr Ile Val Asn Tyr Leu Arg His Ile Tyr Arg Leu Met Arg 
    210                 215                 220                 

Trp Glu Gly Glu Ile Asp Arg Leu Val Lys Phe Ser Leu Val Gly Leu 
225                 230                 235                 240 

Ser Gly Val Leu Val Asn Glu Gly Phe Leu Trp Ala Phe Val Glu Phe 
                245                 250                 255     

Phe Gly Trp Asp Lys Val Phe Ser Asn Ile Leu Ala Thr Glu Leu Ala 
            260                 265                 270         

Ile Leu Asn Asn Phe Thr Trp Asn Asp Ile Trp Thr Phe Arg Asp Leu 
        275                 280                 285             

Lys Asn Lys Pro Leu Leu Lys Arg Leu Val Ser Phe His Val Ala Ala 
    290                 295                 300                 

Leu Ser Gly Ala Leu Val Gln Trp Ala Ile Tyr Val Ile Leu Met Ala 
305                 310                 315                 320 

Val Gly Val His Tyr Leu Leu Ala Asn Leu Ile Gly Ile Val Val Ser 
                325                 330                 335     

Phe Ile Val Arg Phe Ala Val Asn Arg His Val Thr Trp 
            340                 345                 

<210>   260
<211>   348
<212>   PRT
<213>   Pyrococcus furiosus DSM 3638

<400>   260
Val Ser Val Ile Ile Pro Thr Tyr Asn Glu Arg Glu Asn Leu Glu Glu 
                5                   10                  15      

Leu Phe Ser Arg Ile Asp Asn Ala Leu Gln Gly Leu Asn Tyr Glu Ile 
            20                  25                  30          

Val Val Val Asp Asp Asp Ser Pro Asp Arg Thr Trp Glu Lys Ala Gln 
        35                  40                  45              

Glu Leu Ser Ser Lys Tyr Pro Val Lys Val Ile Arg Arg Thr Lys Glu 
    50                  55                  60                  

Lys Gly Leu Ser Ser Ala Val Ile Arg Gly Phe Lys Glu Ala Ser Gly 
65                  70                  75                  80  

Asp Val Phe Val Val Met Asp Ala Asp Leu Gln His Pro Pro Glu Val 
                85                  90                  95      

Ile Pro Lys Leu Ile Glu Ala Ile Lys Asn Gly Ser Asp Ile Ala Ile 
            100                 105                 110         

Gly Ser Arg Tyr Val Lys Gly Gly Lys Val Glu Asn Trp Pro Phe Tyr 
        115                 120                 125             

Arg Lys Leu Ile Ser Lys Gly Ala Ile Met Val Gly Arg Ile Ala Leu 
    130                 135                 140                 

Pro Lys Ile Arg Asp Ile Lys Asp Pro Val Ser Gly Phe Phe Ala Leu 
145                 150                 155                 160 

Arg Lys Glu Val Val Glu Gly Val Glu Leu Asn Pro Ile Gly Phe Lys 
                165                 170                 175     

Ile Leu Met Glu Ile Leu Ile Lys Gly Lys Tyr Ser Lys Val Val Glu 
            180                 185                 190         

Val Pro Phe Thr Phe Gly Ile Arg Ala Arg Gly Glu Ser Lys Leu Lys 
        195                 200                 205             

Gly Lys Thr Ile Phe Glu Tyr Leu Arg His Ile Tyr Arg Leu Met Lys 
    210                 215                 220                 

Trp Glu Gly Glu Ile Asp Arg Ile Val Lys Phe Ser Ile Val Gly Leu 
225                 230                 235                 240 

Ser Gly Ile Leu Val Asn Glu Gly Phe Leu Trp Leu Phe Val Asn Leu 
                245                 250                 255     

Gly Ile Pro Lys Glu Ile Ala Val Ile Pro Ala Val Glu Leu Ser Ile 
            260                 265                 270         

Leu Asn Asn Phe Phe Trp Asn Asp Ile Trp Thr Phe Lys Asp Ile Arg 
        275                 280                 285             

Arg Gly Ser Ile Phe Ser Arg Leu Leu Lys Phe His Ile Ala Ala Leu 
    290                 295                 300                 

Ser Gly Ala Val Val Asn Phe Ile Val Tyr Trp Ile Leu Leu Phe Leu 
305                 310                 315                 320 

Gly Ile His Tyr Leu Ile Ala Asn Leu Val Gly Ile Val Leu Ser Phe 
                325                 330                 335     

Gly Val Arg Tyr Val Ile Asn Arg His Val Thr Trp 
            340                 345             

<210>   261
<211>   349
<212>   PRT
<213>   Pyrococcus horikoshii OT3

<400>   261
Val Ser Ile Ile Val Pro Thr Tyr Asn Glu Arg Asp Asn Leu Glu Glu 
                5                   10                  15      

Leu Phe Ser Arg Ile Ser Ser Ala Leu Lys Gly Tyr Asp Tyr Glu Ile 
            20                  25                  30          

Ile Ile Val Asp Asp Asp Ser Pro Asp Lys Thr Trp Glu Lys Ala Met 
        35                  40                  45              

Glu Leu Ser Lys Leu Tyr Pro Val Lys Val Ile Arg Arg Val Asn Glu 
    50                  55                  60                  

Lys Gly Leu Ser Ser Ala Val Ile Arg Gly Phe Ser Glu Ala Ser Gly 
65                  70                  75                  80  

Asp Val Phe Val Val Met Asp Ala Asp Leu Gln His Pro Pro Glu Val 
                85                  90                  95      

Ile Pro Ser Leu Leu Arg Glu Ile Glu Lys Gly Asn Asp Ile Ala Ile 
            100                 105                 110         

Ala Ser Arg Tyr Val Lys Gly Gly Lys Val Glu Asn Trp Pro Phe Tyr 
        115                 120                 125             

Arg Arg Leu Ile Ser Arg Gly Ala Ile Ile Ile Gly Arg Leu Ala Leu 
    130                 135                 140                 

Pro Lys Ile Ala Gly Ile Lys Asp Pro Val Ser Gly Phe Phe Ala Leu 
145                 150                 155                 160 

Lys Arg Ser Val Val Glu Gly Val Lys Leu Asn Pro Ile Gly Phe Lys 
                165                 170                 175     

Ile Leu Met Glu Ile Leu Ile Lys Gly Lys Tyr Ser Arg Val Thr Glu 
            180                 185                 190         

Val Pro Phe Thr Phe Ser Thr Arg Lys Phe Gly Glu Ser Lys Leu Lys 
        195                 200                 205             

Gly Lys Thr Met Val Asn Tyr Leu Arg His Val Tyr Arg Leu Met Lys 
    210                 215                 220                 

Trp Glu Gly Glu Val Asp Arg Ile Leu Lys Phe Ser Ile Val Gly Leu 
225                 230                 235                 240 

Ser Gly Val Gly Val Asn Glu Gly Phe Leu Trp Leu Phe Val Asn Phe 
                245                 250                 255     

Phe His Ile Ser Lys Glu Leu Gly Val Ile Pro Ser Thr Glu Leu Ser 
            260                 265                 270         

Ile Leu Asn Asn Phe Leu Trp Asn Asp Leu Trp Thr Phe Lys Asp Ile 
        275                 280                 285             

Lys Lys Gly Ser Val Ile Glu Arg Leu Ala Lys Phe His Val Ala Ala 
    290                 295                 300                 

Phe Val Gly Ala Val Ala Gln Phe Leu Val Tyr Trp Ile Leu Leu Phe 
305                 310                 315                 320 

Leu Gly Ile His Tyr Leu Leu Ala Asn Leu Phe Gly Ile Gly Ala Ser 
                325                 330                 335     

Phe Val Val Arg Tyr Ile Phe Asn Arg His Ile Thr Trp 
            340                 345                 

<210>   262
<211>   353
<212>   PRT
<213>   Pyrococcus abyssi GE5

<400>   262
Ala Leu Ile Met Lys Val Ser Val Ile Val Pro Thr Tyr Asn Glu Arg 
                5                   10                  15      

Glu Asn Leu Glu Glu Leu Phe Ser Arg Ile Asp Lys Ala Leu Lys Asp 
            20                  25                  30          

Tyr Asp Tyr Glu Ile Ile Val Val Asp Asp Asp Ser Pro Asp Glu Thr 
        35                  40                  45              

Trp Lys Lys Ala Gln Glu Leu Ser Ser Val Tyr Pro Val Lys Val Ile 
    50                  55                  60                  

Arg Arg Ile Asn Glu Lys Gly Leu Ser Ser Ala Val Ile Arg Gly Phe 
65                  70                  75                  80  

Lys Glu Ala Ser Gly Asp Val Phe Val Val Met Asp Ala Asp Leu Gln 
                85                  90                  95      

His Pro Pro Glu Val Ile Pro Glu Leu Leu Lys Arg Ile Lys Glu Gly 
            100                 105                 110         

Ala Asp Leu Ala Ile Ala Ser Arg Tyr Val Lys Gly Gly Arg Val Glu 
        115                 120                 125             

Asn Trp Pro Leu Tyr Arg Lys Leu Ile Ser Lys Gly Ala Ile Met Ile 
    130                 135                 140                 

Ala Arg Val Ala Leu Pro Lys Ile Arg Ser Ile Lys Asp Pro Val Ser 
145                 150                 155                 160 

Gly Phe Phe Ala Leu Lys Arg Asn Val Val Asp Asn Val Asn Leu Asn 
                165                 170                 175     

Pro Ile Gly Phe Lys Ile Leu Leu Glu Ile Leu Ile Lys Gly Arg Tyr 
            180                 185                 190         

Ser Arg Val Glu Glu Val Pro Phe Thr Phe Gly Thr Arg Leu Ser Gly 
        195                 200                 205             

Glu Ser Lys Leu Lys Gly Lys Thr Met Leu Asn Tyr Leu Arg His Val 
    210                 215                 220                 

Tyr Arg Leu Met Lys Trp Glu Gly Glu Ile Asp Arg Leu Val Lys Phe 
225                 230                 235                 240 

Ser Ile Val Gly Leu Ser Gly Val Ala Val Asn Glu Gly Phe Leu Trp 
                245                 250                 255     

Leu Phe Val Lys Met Gly Ile Arg Lys Glu Val Ala Val Leu Pro Ser 
            260                 265                 270         

Thr Glu Leu Ser Val Ile Asn Asn Phe Ile Trp Asn Asp Leu Trp Thr 
        275                 280                 285             

Phe Lys Asp Leu Arg Lys Gly Ser Val Leu Arg Arg Phe Phe Gln Phe 
    290                 295                 300                 

His Ile Ala Ala Leu Ile Gly Val Phe Ala Gln Leu Leu Ile Tyr Trp 
305                 310                 315                 320 

Ala Leu Leu Phe Leu Gly Val His Tyr Leu Ile Ser Asn Leu Val Gly 
                325                 330                 335     

Ile Gly Ala Ser Phe Ile Val Arg Tyr Ile Phe Asn Arg His Val Thr 
            340                 345                 350         

Trp 
    

<210>   263
<211>   408
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 256

<400>   263
Met Arg Gly Ser Ala Met Met Asp Arg Ala Lys Pro Arg Ile Gly Arg 
                5                   10                  15      

Pro Trp Arg Lys Glu Ala Leu Cys Val Asp Val Ser Val Val Ile Pro 
            20                  25                  30          

Thr Tyr Asn Glu Arg Asp Asn Ile His Pro Leu Val Glu Arg Ile His 
        35                  40                  45              

Gln Ala Leu Ala Pro Leu Gly Ile Ser Tyr Glu Ile Trp Phe Val Asp 
    50                  55                  60                  

Asp Ser Ser Asp Asp Thr Val Ala Val Leu Lys Asp Leu Glu Ala Arg 
65                  70                  75                  80  

Asp Pro Ala Val His Val Phe His Arg Asp His Glu Arg Gly Leu Ala 
                85                  90                  95      

Ser Ala Val Val Arg Gly Phe Glu Lys Ala Gln Gly Arg Tyr Leu Val 
            100                 105                 110         

Val Met Asp Ala Asp Leu Gln His Pro Pro Glu Leu Leu Pro Ala Ile 
        115                 120                 125             

Tyr Glu Arg Leu Glu Ser Gly Ile Asp Val Val Ile Pro Ser Arg Phe 
    130                 135                 140                 

Val Glu Gly Gly Ser Asp Gly Gly Leu Gly Pro Leu Arg Lys Leu Ile 
145                 150                 155                 160 

Ser Trp Thr Ala Arg Val Ile Gly Gln Leu Ala Leu His Arg Leu Arg 
                165                 170                 175     

Lys Ile Ser Asp Cys Thr Ser Gly Phe Phe Gly Leu Arg Arg Glu Val 
            180                 185                 190         

Ile Glu Gly Val Glu Leu Asn Pro Ile Gly Trp Lys Ile Leu Ile Glu 
        195                 200                 205             

Val Leu Val Lys Gly Arg Tyr Arg Ser Val His Glu Ile Ala Tyr Glu 
    210                 215                 220                 

Phe Val Ala Arg Asp Phe Gly Glu Ser Lys Met Ser Leu Lys Glu Gln 
225                 230                 235                 240 

Trp Asn Tyr Phe Arg His Leu Val Arg Leu Val Ser Gln Ser Pro Pro 
                245                 250                 255     

Asp Arg Arg Phe Phe Leu Phe Cys Leu Ile Gly Leu Ser Gly Val Val 
            260                 265                 270         

Val Asn Glu Ala Val Leu Ser Leu Leu Trp Tyr Gly Phe His Leu Arg 
        275                 280                 285             

Asp Thr Val Ala Ser Val Ala Ala Ser Phe Val Ala Met Leu Asn Asn 
    290                 295                 300                 

Tyr Phe Trp Asn Asp Arg Val Thr Trp Lys Ser Glu Ser Ser Gly Arg 
305                 310                 315                 320 

Gly Trp Gly Trp Lys Leu Pro Val Phe Val Gly Ile Ser Val Val Gly 
                325                 330                 335     

Ile Ala Ile Thr Thr Leu Val Met Arg Gly Cys Glu Gly Phe Gly Val 
            340                 345                 350         

Pro Val Pro Ala Gly Gln Ala Ile Gly Ile Leu Val Ser Thr Ala Trp 
        355                 360                 365             

Ser Tyr Trp Met Asn Ser Arg Val Thr Trp Arg Asn Ile Glu Arg Glu 
    370                 375                 380                 

Ala Arg Gly Asp Ala Ile Val Val Thr Arg Glu Ser Val Arg Asp Ser 
385                 390                 395                 400 

Leu Met Arg Ala Lys Thr Gly Ala 
                405             

<210>   264
<211>   408
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 256

<400>   264
Met Arg Gly Ser Ala Met Met Asp Arg Ala Lys Pro Arg Ile Gly Arg 
                5                   10                  15      

Pro Trp Arg Lys Glu Ala Leu Cys Val Asp Val Ser Val Val Ile Pro 
            20                  25                  30          

Thr Tyr Asn Glu Arg Asp Asn Ile His Pro Leu Val Glu Arg Ile His 
        35                  40                  45              

Gln Ala Leu Ala Pro Leu Gly Ile Ser Tyr Glu Ile Trp Phe Val Asp 
    50                  55                  60                  

Asp Ser Ser Asp Asp Thr Val Ala Val Leu Arg Asp Leu Glu Ala Arg 
65                  70                  75                  80  

Asp Pro Ala Val His Val Phe His Arg Asp His Glu Arg Gly Leu Ala 
                85                  90                  95      

Ser Ala Val Val Arg Gly Phe Glu Lys Ala Gln Gly Arg Tyr Leu Val 
            100                 105                 110         

Val Met Asp Ala Asp Leu Gln His Pro Pro Glu Leu Leu Pro Ala Ile 
        115                 120                 125             

Tyr Glu Arg Leu Glu Ser Gly Ile Asp Val Val Ile Pro Ser Arg Phe 
    130                 135                 140                 

Val Glu Gly Gly Ser Asp Gly Gly Leu Gly Pro Leu Arg Lys Leu Ile 
145                 150                 155                 160 

Ser Trp Thr Ala Arg Val Ile Gly Gln Leu Ala Leu His Arg Leu Arg 
                165                 170                 175     

Lys Ile Ser Asp Cys Thr Ser Gly Phe Phe Gly Leu Arg Arg Glu Val 
            180                 185                 190         

Ile Glu Gly Val Glu Leu Asn Pro Ile Gly Trp Lys Ile Leu Ile Glu 
        195                 200                 205             

Val Leu Val Lys Gly Arg Tyr Arg Ser Val His Glu Ile Ala Tyr Glu 
    210                 215                 220                 

Phe Val Ala Arg Asp Phe Gly Glu Ser Lys Met Ser Leu Lys Glu Gln 
225                 230                 235                 240 

Trp Asn Tyr Phe Arg His Leu Val Arg Leu Val Ser Gln Ser Pro Pro 
                245                 250                 255     

Asp Arg Arg Phe Phe Leu Phe Cys Leu Ile Gly Leu Ser Gly Val Val 
            260                 265                 270         

Val Asn Glu Ala Val Leu Ser Leu Leu Trp Tyr Gly Phe His Leu Arg 
        275                 280                 285             

Asp Thr Val Ala Ser Val Ala Ala Ser Phe Val Ala Met Leu Asn Asn 
    290                 295                 300                 

Tyr Phe Trp Asn Asp Arg Val Thr Trp Lys Ser Glu Ser Ser Gly Arg 
305                 310                 315                 320 

Gly Trp Gly Trp Lys Leu Pro Val Phe Val Gly Ile Ser Val Val Gly 
                325                 330                 335     

Ile Ala Ile Thr Thr Leu Val Met Arg Gly Cys Glu Gly Phe Gly Val 
            340                 345                 350         

Pro Val Pro Ala Gly Gln Ala Ile Gly Ile Leu Val Ser Thr Ala Trp 
        355                 360                 365             

Ser Tyr Trp Met Asn Ser Arg Val Thr Trp Arg Asn Ile Glu Arg Asp 
    370                 375                 380                 

Ala Arg Gly Asp Ala Ile Val Val Thr Arg Glu Ser Val Arg Asp Ser 
385                 390                 395                 400 

Leu Met Arg Ala Lys Thr Gly Ala 
                405             

<210>   265
<211>   408
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 256

<400>   265
Met Arg Gly Ser Ala Met Met Asp Arg Ala Lys Pro Arg Ile Gly Arg 
                5                   10                  15      

Pro Trp Arg Lys Glu Ala Leu Cys Val Asp Val Ser Val Val Ile Pro 
            20                  25                  30          

Thr Tyr Asn Glu Arg Asp Asn Ile His Pro Leu Val Glu Arg Ile His 
        35                  40                  45              

Gln Ala Leu Ala Pro Leu Gly Ile Ser Tyr Glu Ile Trp Phe Val Asp 
    50                  55                  60                  

Asp Ser Ser Asp Asp Thr Val Ala Val Leu Arg Asp Leu Glu Ala Arg 
65                  70                  75                  80  

Asp Pro Ala Val His Val Phe His Arg Asp His Glu Arg Gly Leu Ala 
                85                  90                  95      

Ser Ala Val Val Arg Gly Phe Glu Lys Ala Gln Gly Arg Tyr Leu Val 
            100                 105                 110         

Val Met Asp Ala Asp Leu Gln His Pro Pro Glu Leu Leu Pro Ala Ile 
        115                 120                 125             

Tyr Glu Arg Leu Glu Ser Gly Ile Asp Val Val Ile Pro Ser Arg Phe 
    130                 135                 140                 

Val Glu Gly Gly Ser Asp Gly Gly Leu Gly Pro Leu Arg Lys Leu Ile 
145                 150                 155                 160 

Ser Trp Thr Ala Arg Val Ile Gly Gln Leu Ala Leu His Arg Leu Arg 
                165                 170                 175     

Lys Ile Ser Asp Cys Thr Ser Gly Phe Phe Gly Leu Arg Arg Glu Val 
            180                 185                 190         

Ile Glu Gly Val Glu Leu Asn Pro Ile Gly Trp Lys Ile Leu Ile Glu 
        195                 200                 205             

Val Leu Val Lys Gly Arg Tyr Arg Ser Val His Glu Ile Ala Tyr Glu 
    210                 215                 220                 

Phe Val Ala Arg Asp Phe Gly Glu Ser Lys Met Ser Leu Lys Glu Gln 
225                 230                 235                 240 

Trp Asn Tyr Phe Arg His Leu Val Arg Leu Val Ser Gln Ser Pro Pro 
                245                 250                 255     

Asp Arg Arg Phe Phe Leu Phe Cys Leu Ile Gly Leu Ser Gly Val Val 
            260                 265                 270         

Val Asn Glu Ala Val Leu Ser Leu Leu Trp Tyr Gly Phe His Leu Arg 
        275                 280                 285             

Asp Thr Val Ala Ser Val Ala Ala Ser Phe Val Ala Met Leu Asn Asn 
    290                 295                 300                 

Tyr Phe Trp Asn Asp Arg Val Thr Trp Lys Ser Glu Ser Ser Gly Arg 
305                 310                 315                 320 

Gly Trp Gly Trp Lys Leu Pro Val Phe Val Gly Ile Ser Val Val Gly 
                325                 330                 335     

Ile Ala Ile Thr Thr Leu Val Met Arg Gly Cys Glu Gly Phe Gly Val 
            340                 345                 350         

Pro Val Pro Ala Gly Gln Ala Ile Gly Ile Leu Val Ser Thr Ala Trp 
        355                 360                 365             

Ser Tyr Trp Met Asn Ser Arg Val Thr Trp Arg Asn Ile Glu Arg Glu 
    370                 375                 380                 

Ala Arg Gly Asp Ala Ile Val Val Thr Arg Glu Ser Val Arg Asp Ser 
385                 390                 395                 400 

Leu Met Arg Ala Arg Thr Gly Ala 
                405             

<210>   266
<211>   408
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 256

<400>   266
Met Arg Gly Ser Ala Met Met Asp Arg Ala Lys Pro Arg Ile Gly Arg 
                5                   10                  15      

Pro Trp Arg Lys Glu Ala Leu Cys Val Asp Val Ser Val Val Ile Pro 
            20                  25                  30          

Thr Tyr Asn Glu Arg Asp Asn Ile His Pro Leu Val Glu Arg Ile His 
        35                  40                  45              

Gln Ala Leu Ala Pro Leu Gly Ile Ser Tyr Glu Ile Trp Phe Val Asp 
    50                  55                  60                  

Asp Ser Ser Asp Asp Thr Val Ala Val Leu Arg Asp Leu Glu Ala Arg 
65                  70                  75                  80  

Asp Pro Ala Val His Val Phe His Arg Asp His Glu Arg Gly Leu Ala 
                85                  90                  95      

Ser Ala Val Val Arg Gly Phe Glu Lys Ala Gln Gly Arg Tyr Leu Val 
            100                 105                 110         

Val Met Asp Ala Asp Leu Gln His Pro Pro Glu Leu Leu Pro Ala Ile 
        115                 120                 125             

Tyr Glu Arg Leu Glu Ser Gly Ile Asp Val Val Ile Pro Ser Arg Phe 
    130                 135                 140                 

Val Glu Gly Gly Ser Asp Gly Gly Leu Gly Pro Leu Arg Lys Leu Ile 
145                 150                 155                 160 

Ser Trp Thr Ala Arg Val Ile Gly Gln Leu Ala Leu His Arg Leu Arg 
                165                 170                 175     

Lys Ile Ser Asp Cys Thr Ser Gly Phe Phe Gly Leu Arg Arg Glu Val 
            180                 185                 190         

Ile Glu Gly Val Glu Leu Asn Pro Ile Gly Trp Lys Ile Leu Ile Glu 
        195                 200                 205             

Val Leu Val Lys Gly Arg Tyr Arg Ser Val His Glu Ile Ala Tyr Glu 
    210                 215                 220                 

Phe Val Ala Arg Asp Phe Gly Glu Ser Lys Met Ser Leu Lys Glu Gln 
225                 230                 235                 240 

Trp Asn Tyr Phe Arg His Leu Val Arg Leu Val Ser Gln Ser Pro Pro 
                245                 250                 255     

Asp Arg Arg Phe Phe Leu Phe Cys Leu Ile Gly Leu Ser Gly Val Val 
            260                 265                 270         

Val Asn Glu Ala Val Leu Ser Leu Leu Trp Tyr Gly Phe His Leu Arg 
        275                 280                 285             

Asp Thr Val Ala Ser Val Ala Ala Ser Phe Val Ala Met Leu Asn Asn 
    290                 295                 300                 

Tyr Phe Trp Asn Asp Arg Val Thr Trp Lys Ser Glu Ser Ser Gly Arg 
305                 310                 315                 320 

Gly Trp Gly Trp Lys Leu Pro Val Phe Val Gly Ile Ser Val Val Gly 
                325                 330                 335     

Ile Ala Ile Thr Thr Leu Val Met Arg Gly Cys Glu Gly Phe Gly Val 
            340                 345                 350         

Pro Val Pro Ala Gly Gln Ala Ile Gly Ile Leu Val Ser Thr Ala Trp 
        355                 360                 365             

Ser Tyr Trp Met Asn Ser Arg Val Thr Trp Arg Asn Ile Asp Arg Glu 
    370                 375                 380                 

Ala Arg Gly Asp Ala Ile Val Val Thr Arg Glu Ser Val Arg Asp Ser 
385                 390                 395                 400 

Leu Met Arg Ala Lys Thr Gly Ala 
                405             

<210>   267
<211>   408
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 256

<400>   267
Met Arg Gly Ser Ala Met Met Asp Arg Ala Lys Pro Arg Ile Gly Arg 
                5                   10                  15      

Pro Trp Arg Lys Glu Ala Leu Cys Val Asp Val Ser Val Val Ile Pro 
            20                  25                  30          

Thr Tyr Asn Glu Arg Asp Asn Ile His Pro Leu Val Glu Arg Ile His 
        35                  40                  45              

Gln Ala Leu Ala Pro Leu Gly Ile Ser Tyr Glu Ile Trp Phe Val Asp 
    50                  55                  60                  

Asp Ser Ser Asp Asp Thr Val Ala Val Leu Arg Asp Leu Glu Ala Arg 
65                  70                  75                  80  

Asp Pro Ala Val His Val Phe His Arg Asp His Glu Arg Gly Leu Ala 
                85                  90                  95      

Ser Ala Val Val Arg Gly Phe Glu Lys Ala Gln Gly Arg Tyr Leu Val 
            100                 105                 110         

Val Met Asp Ala Asp Leu Gln His Pro Pro Glu Ile Leu Pro Ala Ile 
        115                 120                 125             

Tyr Glu Arg Leu Glu Ser Gly Ile Asp Val Val Ile Pro Ser Arg Phe 
    130                 135                 140                 

Val Glu Gly Gly Ser Asp Gly Gly Leu Gly Pro Leu Arg Lys Leu Ile 
145                 150                 155                 160 

Ser Trp Thr Ala Arg Val Ile Gly Gln Leu Ala Leu His Arg Leu Arg 
                165                 170                 175     

Lys Ile Ser Asp Cys Thr Ser Gly Phe Phe Gly Leu Arg Arg Glu Val 
            180                 185                 190         

Ile Glu Gly Val Glu Leu Asn Pro Ile Gly Trp Lys Ile Leu Ile Glu 
        195                 200                 205             

Val Leu Val Lys Gly Arg Tyr Arg Ser Val His Glu Ile Ala Tyr Glu 
    210                 215                 220                 

Phe Val Ala Arg Asp Phe Gly Glu Ser Lys Met Ser Leu Lys Glu Gln 
225                 230                 235                 240 

Trp Asn Tyr Phe Arg His Leu Val Arg Leu Val Ser Gln Ser Pro Pro 
                245                 250                 255     

Asp Arg Arg Phe Phe Leu Phe Cys Leu Ile Gly Leu Ser Gly Val Val 
            260                 265                 270         

Val Asn Glu Ala Val Leu Ser Leu Leu Trp Tyr Gly Phe His Leu Arg 
        275                 280                 285             

Asp Thr Val Ala Ser Val Ala Ala Ser Phe Val Ala Met Leu Asn Asn 
    290                 295                 300                 

Tyr Phe Trp Asn Asp Arg Val Thr Trp Lys Ser Glu Ser Ser Gly Arg 
305                 310                 315                 320 

Gly Trp Gly Trp Lys Leu Pro Val Phe Val Gly Ile Ser Val Val Gly 
                325                 330                 335     

Ile Ala Ile Thr Thr Leu Val Met Arg Gly Cys Glu Gly Phe Gly Val 
            340                 345                 350         

Pro Val Pro Ala Gly Gln Ala Ile Gly Ile Leu Val Ser Thr Ala Trp 
        355                 360                 365             

Ser Tyr Trp Met Asn Ser Arg Val Thr Trp Arg Asn Ile Glu Arg Glu 
    370                 375                 380                 

Ala Arg Gly Asp Ala Ile Val Val Thr Arg Glu Ser Val Arg Asp Ser 
385                 390                 395                 400 

Leu Met Arg Ala Lys Thr Gly Ala 
                405             

<210>   268
<211>   1227
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 257

<400>   268
gtgcgtggtt ccgcgatgat ggacagggcc aagcctcgga tcggtaggcc ttggcgcaag       60

gaggctttgt gcgtggacgt cagtgtggtg atcccgactt acaacgagcg agacaacatc      120

catcccctgg tggagcgcat ccatcaagct ttagcccctc tggggatttc ctacgagatc      180

tggtttgtcg atgacagcag cgacgatacg gtcgcagtgc ttaaagatct ggaggcccgg      240

gatcccgccg ttcacgtgtt ccaccgcgat cacgagcgtg gcctcgcgag cgcggtcgtg      300

cgtggattcg aaaaggcgca gggcaggtac cttgtcgtga tggacgctga cctgcagcat      360

ccgccggagc tgttgccggc catctacgag cgtttggagt ccgggatcga cgtggtaatc      420

ccaagccgtt tcgtggaagg gggctcggac ggcgggttgg gcccgctgcg aaagctcatc      480

tcgtggaccg cgcgggtcat tgggcaactc gcgctccatc gcctgcgcaa gatctcggat      540

tgcacgagcg gtttctttgg cctgcggcgc gaagtgattg aaggcgtcga actgaacccc      600

attggatgga agatcttgat cgaggtgctg gtgaaaggcc gctatcgcag cgtgcatgag      660

atcgcgtacg agttcgtggc ccgcgacttc ggcgaatcga agatgagcct caaggagcag      720

tggaactact ttcgccacct cgtgcgcctg gtgagccaga gcccgccgga tcggcggttc      780

tttctgttct gcctcatcgg cctgtcgggc gtggtggtga acgaggcagt cctgagcctc      840

ctgtggtacg ggttccacct gcgggacacc gtggcttccg tcgccgcttc tttcgtggcc      900

atgttgaaca actatttttg gaacgatcgc gtcacgtgga aatccgagtc ctccggacga      960

gggtggggat ggaagctgcc cgtgttcgtc ggcatttcgg tcgtcgggat cgccatcacg     1020

acgctcgtga tgcgaggatg cgagggcttt ggcgtgcccg ttcccgctgg acaggccatc     1080

ggcatcctgg tgtccacagc gtggtcgtat tggatgaaca gccgcgtgac ttggcgaaac     1140

atcgagcgcg aagcgcgtgg ggatgcgatt gtggtcacac gggagtcggt gcgggattcg     1200

ctgatgcggg cgaaaacagg cgcgtga                                         1227


<210>   269
<211>   1227
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 257

<400>   269
gtgcgtggtt ccgcgatgat ggacagggcc aagcctcgga tcggtaggcc ttggcgcaag       60

gaggctttgt gcgtggacgt cagtgtggtg atcccgactt acaacgagcg agacaacatc      120

catcccctgg tggagcgcat ccatcaagct ttagcccctc tggggatttc ctacgagatc      180

tggtttgtcg atgacagcag cgacgatacg gtcgcagtgc ttcgagatct ggaggcccgg      240

gatcccgccg ttcacgtgtt ccaccgcgat cacgagcgtg gcctcgcgag cgcggtcgtg      300

cgtggattcg aaaaggcgca gggcaggtac cttgtcgtga tggacgctga cctgcagcat      360

ccgccggagc tgttgccggc catctacgag cgtttggagt ccgggatcga cgtggtaatc      420

ccaagccgtt tcgtggaagg gggctcggac ggcgggttgg gcccgctgcg aaagctcatc      480

tcgtggaccg cgcgggtcat tgggcaactc gcgctccatc gcctgcgcaa gatctcggat      540

tgcacgagcg gtttctttgg cctgcggcgc gaagtgattg aaggcgtcga actgaacccc      600

attggatgga agatcttgat cgaggtgctg gtgaaaggcc gctatcgcag cgtgcatgag      660

atcgcgtacg agttcgtggc ccgcgacttc ggcgaatcga agatgagcct caaggagcag      720

tggaactact ttcgccacct cgtgcgcctg gtgagccaga gcccgccgga tcggcggttc      780

tttctgttct gcctcatcgg cctgtcgggc gtggtggtga acgaggcagt cctgagcctc      840

ctgtggtacg ggttccacct gcgggacacc gtggcttccg tcgccgcttc tttcgtggcc      900

atgttgaaca actatttttg gaacgatcgc gtcacgtgga aatccgagtc ctccggacga      960

gggtggggat ggaagctgcc cgtgttcgtc ggcatttcgg tcgtcgggat cgccatcacg     1020

acgctcgtga tgcgaggatg cgagggcttt ggcgtgcccg ttcccgctgg acaggccatc     1080

ggcatcctgg tgtccacagc gtggtcgtat tggatgaaca gccgcgtgac ttggcgaaac     1140

atcgagcgcg atgcgcgtgg ggatgcgatt gtggtcacac gggagtcggt gcgggattcg     1200

ctgatgcggg cgaaaacagg cgcgtga                                         1227


<210>   270
<211>   1227
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 257

<400>   270
gtgcgtggtt ccgcgatgat ggacagggcc aagcctcgga tcggtaggcc ttggcgcaag       60

gaggctttgt gcgtggacgt cagtgtggtg atcccgactt acaacgagcg agacaacatc      120

catcccctgg tggagcgcat ccatcaagct ttagcccctc tggggatttc ctacgagatc      180

tggtttgtcg atgacagcag cgacgatacg gtcgcagtgc ttcgagatct ggaggcccgg      240

gatcccgccg ttcacgtgtt ccaccgcgat cacgagcgtg gcctcgcgag cgcggtcgtg      300

cgtggattcg aaaaggcgca gggcaggtac cttgtcgtga tggacgctga cctgcagcat      360

ccgccggagc tgttgccggc catctacgag cgtttggagt ccgggatcga cgtggtaatc      420

ccaagccgtt tcgtggaagg gggctcggac ggcgggttgg gcccgctgcg aaagctcatc      480

tcgtggaccg cgcgggtcat tgggcaactc gcgctccatc gcctgcgcaa gatctcggat      540

tgcacgagcg gtttctttgg cctgcggcgc gaagtgattg aaggcgtcga actgaacccc      600

attggatgga agatcttgat cgaggtgctg gtgaaaggcc gctatcgcag cgtgcatgag      660

atcgcgtacg agttcgtggc ccgcgacttc ggcgaatcga agatgagcct caaggagcag      720

tggaactact ttcgccacct cgtgcgcctg gtgagccaga gcccgccgga tcggcggttc      780

tttctgttct gcctcatcgg cctgtcgggc gtggtggtga acgaggcagt cctgagcctc      840

ctgtggtacg ggttccacct gcgggacacc gtggcttccg tcgccgcttc tttcgtggcc      900

atgttgaaca actatttttg gaacgatcgc gtcacgtgga aatccgagtc ctccggacga      960

gggtggggat ggaagctgcc cgtgttcgtc ggcatttcgg tcgtcgggat cgccatcacg     1020

acgctcgtga tgcgaggatg cgagggcttt ggcgtgcccg ttcccgctgg acaggccatc     1080

ggcatcctgg tgtccacagc gtggtcgtat tggatgaaca gccgcgtgac ttggcgaaac     1140

atcgagcgcg aagcgcgtgg ggatgcgatt gtggtcacac gggagtcggt gcgggattcg     1200

ctgatgcggg cgcgtacagg cgcgtga                                         1227


<210>   271
<211>   1227
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 257

<400>   271
gtgcgtggtt ccgcgatgat ggacagggcc aagcctcgga tcggtaggcc ttggcgcaag       60

gaggctttgt gcgtggacgt cagtgtggtg atcccgactt acaacgagcg agacaacatc      120

catcccctgg tggagcgcat ccatcaagct ttagcccctc tggggatttc ctacgagatc      180

tggtttgtcg atgacagcag cgacgatacg gtcgcagtgc ttcgagatct ggaggcccgg      240

gatcccgccg ttcacgtgtt ccaccgcgat cacgagcgtg gcctcgcgag cgcggtcgtg      300

cgtggattcg aaaaggcgca gggcaggtac cttgtcgtga tggacgctga cctgcagcat      360

ccgccggagc tgttgccggc catctacgag cgtttggagt ccgggatcga cgtggtaatc      420

ccaagccgtt tcgtggaagg gggctcggac ggcgggttgg gcccgctgcg aaagctcatc      480

tcgtggaccg cgcgggtcat tgggcaactc gcgctccatc gcctgcgcaa gatctcggat      540

tgcacgagcg gtttctttgg cctgcggcgc gaagtgattg aaggcgtcga actgaacccc      600

attggatgga agatcttgat cgaggtgctg gtgaaaggcc gctatcgcag cgtgcatgag      660

atcgcgtacg agttcgtggc ccgcgacttc ggcgaatcga agatgagcct caaggagcag      720

tggaactact ttcgccacct cgtgcgcctg gtgagccaga gcccgccgga tcggcggttc      780

tttctgttct gcctcatcgg cctgtcgggc gtggtggtga acgaggcagt cctgagcctc      840

ctgtggtacg ggttccacct gcgggacacc gtggcttccg tcgccgcttc tttcgtggcc      900

atgttgaaca actatttttg gaacgatcgc gtcacgtgga aatccgagtc ctccggacga      960

gggtggggat ggaagctgcc cgtgttcgtc ggcatttcgg tcgtcgggat cgccatcacg     1020

acgctcgtga tgcgaggatg cgagggcttt ggcgtgcccg ttcccgctgg acaggccatc     1080

ggcatcctgg tgtccacagc gtggtcgtat tggatgaaca gccgcgtgac ttggcgaaac     1140

atcgatcgcg aagcgcgtgg ggatgcgatt gtggtcacac gggagtcggt gcgggattcg     1200

ctgatgcggg cgaaaacagg cgcgtga                                         1227


<210>   272
<211>   1227
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 257

<400>   272
gtgcgtggtt ccgcgatgat ggacagggcc aagcctcgga tcggtaggcc ttggcgcaag       60

gaggctttgt gcgtggacgt cagtgtggtg atcccgactt acaacgagcg agacaacatc      120

catcccctgg tggagcgcat ccatcaagct ttagcccctc tggggatttc ctacgagatc      180

tggtttgtcg atgacagcag cgacgatacg gtcgcagtgc ttcgagatct ggaggcccgg      240

gatcccgccg ttcacgtgtt ccaccgcgat cacgagcgtg gcctcgcgag cgcggtcgtg      300

cgtggattcg aaaaggcgca gggcaggtac cttgtcgtga tggacgctga cctgcagcat      360

ccgccggaga ttttgccggc catctacgag cgtttggagt ccgggatcga cgtggtaatc      420

ccaagccgtt tcgtggaagg gggctcggac ggcgggttgg gcccgctgcg aaagctcatc      480

tcgtggaccg cgcgggtcat tgggcaactc gcgctccatc gcctgcgcaa gatctcggat      540

tgcacgagcg gtttctttgg cctgcggcgc gaagtgattg aaggcgtcga actgaacccc      600

attggatgga agatcttgat cgaggtgctg gtgaaaggcc gctatcgcag cgtgcatgag      660

atcgcgtacg agttcgtggc ccgcgacttc ggcgaatcga agatgagcct caaggagcag      720

tggaactact ttcgccacct cgtgcgcctg gtgagccaga gcccgccgga tcggcggttc      780

tttctgttct gcctcatcgg cctgtcgggc gtggtggtga acgaggcagt cctgagcctc      840

ctgtggtacg ggttccacct gcgggacacc gtggcttccg tcgccgcttc tttcgtggcc      900

atgttgaaca actatttttg gaacgatcgc gtcacgtgga aatccgagtc ctccggacga      960

gggtggggat ggaagctgcc cgtgttcgtc ggcatttcgg tcgtcgggat cgccatcacg     1020

acgctcgtga tgcgaggatg cgagggcttt ggcgtgcccg ttcccgctgg acaggccatc     1080

ggcatcctgg tgtccacagc gtggtcgtat tggatgaaca gccgcgtgac ttggcgaaac     1140

atcgagcgcg aagcgcgtgg ggatgcgatt gtggtcacac gggagtcggt gcgggattcg     1200

ctgatgcggg cgaaaacagg cgcgtga                                         1227


<210>   273
<211>   759
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   273
Met Arg Arg Ile Val Val Leu Leu Ser Ala Cys Leu Ile Val Lys Asn 
                5                   10                  15      

Glu Ala His Val Leu Pro Arg Cys Leu Gly Ser Leu Gln Gly Val Ala 
            20                  25                  30          

Asp Glu Ile Val Val Val Asp Thr Gly Ser Thr Asp Asp Thr Pro Arg 
        35                  40                  45              

Ile Ala Glu Ser Phe Gly Ala Arg Val Tyr His Phe Glu Trp Thr Gly 
    50                  55                  60                  

Asp Phe Ala Val Ala Arg Asn Glu Ser Leu Arg Tyr Ala Leu Gly Glu 
65                  70                  75                  80  

Tyr Val Leu Val Ile Asp Ala Asp Glu Phe Leu Pro Lys Glu Asp Gly 
                85                  90                  95      

Val Arg Leu Arg Gln Ala Leu Gln Glu Arg Arg Ala Asp Ala Tyr Thr 
            100                 105                 110         

Val Asp Leu Val Asn Tyr Leu Gly Ser Val Ala Arg Phe Val Arg Ser 
        115                 120                 125             

Pro Gly Val Arg Val Val Arg Val Phe Arg Arg Gly Phe Ser Tyr Met 
    130                 135                 140                 

Gly Ser Ile His Glu Gln Ile Leu Tyr Asp Val Ile Ala Lys Gly Gly 
145                 150                 155                 160 

Gln Ile Glu Val Leu Asp Val Glu Ile His His Leu Gly Tyr Leu Ala 
                165                 170                 175     

Glu Phe Val Ala Leu Lys Gly Lys Ser Asp Arg Asn Leu Glu Ile Leu 
            180                 185                 190         

Asn Gln Ala Leu Ala Ile Asp Pro Asp Asn Phe Phe His Ile Thr Asn 
        195                 200                 205             

Leu Met Ala Glu Tyr Ala Arg Leu Gly Asp Pro Lys Lys Val Val Glu 
    210                 215                 220                 

Leu Gly Glu Arg Ala Tyr Asp Leu Phe Gln Arg Gly Arg Val Asn Gln 
225                 230                 235                 240 

Pro His Leu Val Leu Arg Met Tyr Arg Met Met Ile Ala Ala His Gly 
                245                 250                 255     

Asp Leu Gly Asn Tyr Asp Arg Val Glu Ala Leu Ala Arg Glu Ala Glu 
            260                 265                 270         

Leu Phe Phe Pro Asn Ile Pro Asp Val Pro Phe Val His Ala Leu Tyr 
        275                 280                 285             

Val Met Gln Arg Gly Asp Trp Arg Lys Ala Ile Arg Leu Phe Glu Arg 
    290                 295                 300                 

Ser Arg Glu Ile Gly Glu Ile Arg Ser Glu Ile Ile Asp Thr Ile Ala 
305                 310                 315                 320 

Gly Ala Gly Ser Tyr Val Ala Ala Ala Lys Leu Gly Glu Leu Trp Leu 
                325                 330                 335     

Leu Glu Gly Asp Val Glu Leu Ala Arg Glu Tyr Phe Val Gln Ser Leu 
            340                 345                 350         

Arg Glu Asn Leu Arg Gln Glu Gly Thr Phe Phe Phe Leu Ala Ser Leu 
        355                 360                 365             

Leu Pro Leu Asn Asp Pro Ser Val Phe Glu Gln Leu Arg Ala Leu Ala 
    370                 375                 380                 

Ser His Asp Pro Val Cys Leu Ala Tyr Leu Ala Leu Ala Gly Ala Val 
385                 390                 395                 400 

Trp Arg Val Asp His Ala Trp Arg Leu Ile Asn Glu Ile Glu Gln Thr 
                405                 410                 415     

Pro Val Thr Ala Pro Ile Val Ala Lys Leu Arg Ala Leu Gly Ala Val 
            420                 425                 430         

Leu Gly Ile Leu Pro Ala Asn Asp Val Arg Val Asp Ser Thr Val Glu 
        435                 440                 445             

Arg Glu Ile Gln Trp Tyr Glu Ala Leu Phe Ala Leu Glu Arg Gly Asp 
    450                 455                 460                 

Arg Asp Gln Ala Glu Arg Cys Leu Arg Asp Gln Pro Glu Arg Trp Glu 
465                 470                 475                 480 

Arg Leu Ser Glu Trp Leu Thr Ser Lys Gln Gly Leu Cys Ile Ser Pro 
                485                 490                 495     

Ile Leu Asp Glu Leu Leu Leu Ala Arg Val Asp Glu Leu Leu Leu Ala 
            500                 505                 510         

Trp Leu Pro Arg Ala Glu Asp Arg Asp Leu Ala Leu Ser Arg Val Leu 
        515                 520                 525             

Ala Ser Pro Leu Arg Glu Glu Val Trp Lys Ala Ala Trp Leu Gly Glu 
    530                 535                 540                 

Arg Gly Trp Glu Cys Asp Phe Leu Ala Leu Gly Ala Phe Arg Arg Arg 
545                 550                 555                 560 

Asp Ile Gln Ala Ser Leu Asn Trp Leu Glu Arg Gly Leu Thr Tyr Glu 
                565                 570                 575     

Pro Thr Val Arg Arg Ala Ile Val Glu Ile Asp Leu Ala Leu Cys His 
            580                 585                 590         

Lys Asn Ile Ala His Ala Gln Glu Val Ala Ser Gln Ala Ser Arg Leu 
        595                 600                 605             

Phe Pro Glu Ser Lys Leu Leu Glu Gly Ile Ala Gly Ser Leu Gly Val 
    610                 615                 620                 

Ser Pro Arg Pro Met Arg Ser Leu Asp Asp Leu Leu Gly Gly Gly Ser 
625                 630                 635                 640 

Gly Leu Asn Pro His Arg Ala Tyr Gln Ser Ser Val Asn Ser Met Pro 
                645                 650                 655     

Leu Lys Val Lys Ile Met Lys Leu His Glu Arg Ala Val Glu Cys Val 
            660                 665                 670         

Asp Gln Val Lys Ala Leu Val Asp Gln Gly Asp Ile Met Gly Ala Arg 
        675                 680                 685             

Thr Tyr Ile Gln Tyr Val Gln Asp Ile Ile Thr Phe Leu Arg Ser Asn 
    690                 695                 700                 

Leu Asp Thr Ser Thr Glu Ala Gly Lys Ala Ala Asp Ala Ala Tyr Ala 
705                 710                 715                 720 

Tyr Phe Tyr Lys Met Leu Val Glu Trp Phe Leu Gln Pro Ser Lys Val 
                725                 730                 735     

Glu Ser Glu Tyr Lys Glu Met Arg Asp Phe Trp Gln Ser Trp Ala Asp 
            740                 745                 750         

Thr Trp Ala Lys Val Glu Ala 
        755                 

<210>   274
<211>   2280
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   274
gtgaggagaa tcgtcgtgct actttcggcc tgtctcatag tgaaaaacga agctcatgtg       60

ctaccgcgtt gcttaggttc gctccaaggc gtagcagatg aaatcgtggt agtagacaca      120

ggttctacgg atgacactcc tcgcatcgcc gagtcattcg gtgcgcgtgt gtatcatttt      180

gagtggactg gagactttgc ggtagcccga aacgaatcgt tgcgatatgc gctgggcgag      240

tatgtgcttg tgatcgatgc tgatgagttt ttgccaaagg aggacggtgt tcgcctgcgt      300

caggcgctcc aagagaggcg ggccgacgct tatactgtgg acctcgtcaa ctacttagga      360

tcagtggctc gttttgtccg ttcacccggt gttcgcgtgg tgcgcgtctt tcgacgcggt      420

ttctcgtaca tgggttctat ccacgaacaa attttgtacg acgtgatcgc caaaggcggt      480

caaatcgagg ttcttgacgt cgagattcat catttaggtt atctagccga gttcgtagcg      540

cttaaaggca agtcggaccg caatctcgag atcttaaatc aggccctggc aattgatccg      600

gataattttt ttcatatcac gaaccttatg gccgaatacg cccggttagg tgatccaaaa      660

aaagtcgtgg agctgggcga gcgcgcatac gacctttttc agcgcggtcg agttaaccag      720

ccgcatctcg ttctgcgaat gtatcgcatg atgatcgcag cgcacggcga tcttggcaat      780

tatgaccgag tcgaggcact ggcgagagaa gccgagctat tctttccgaa tatcccggac      840

gtcccattcg tccatgcact ctatgtgatg caacgcggcg attggcgaaa ggcgattcgg      900

ctgtttgagc gcagtcgtga aattggtgag attcgatctg agattatcga caccatagct      960

ggcgcgggct catacgtcgc ggctgcgaag ctcggcgaac tctggctact cgagggcgat     1020

gtagaacttg ctcgagaata ttttgtacag agtttacgtg agaacctgcg tcaggagggc     1080

accttctttt tcttagcttc gcttctcccg ctgaatgatc caagcgtatt cgagcaactc     1140

cgtgccctcg cgagccacga tccagtctgt cttgcgtatc ttgccctcgc aggagcagta     1200

tggcgggtcg accatgcttg gcggctcatc aatgaaatcg aacaaacgcc cgtgacggca     1260

ccaatcgtcg caaaactgcg cgcactcggc gcggtacttg gtattctacc cgcaaacgat     1320

gtccgagtgg attcgacggt cgaacgggaa attcaatggt acgaggcgct ctttgcactt     1380

gaacgaggag atcgcgacca ggcagagaga tgcctacgcg accaaccgga gcgttgggag     1440

cgtctgtctg agtggctaac gagcaagcaa ggtctttgca ttagcccgat cctggacgag     1500

ttgctgctag ctcgtgtcga tgagttgctt cttgcgtggc taccaagggc agaagaccga     1560

gatctcgcgc tgtcaagggt tttggcgtct ccgcttcgcg aggaagtctg gaaggctgcg     1620

tggctcggcg aacgcggctg ggagtgcgac tttttggcct tgggtgcgtt tcggcgccgc     1680

gacattcagg caagtctcaa ctggctcgag cgtggtctca cctacgagcc cacagtacgg     1740

cgggccatcg tcgagatcga tctcgcctta tgccacaaaa acatcgctca cgcccaggaa     1800

gtagcaagcc aagcaagtag gttgttccct gaatcgaaac tgttggaggg cattgcaggg     1860

agcctaggcg tctcgccgcg accaatgcgc tctttagacg acttgttggg agggggtagt     1920

ggcttgaatc cacatcgcgc ctaccaatcg tccgtcaaca gcatgccact taaggtaaag     1980

atcatgaagc tccatgagcg ggccgtagag tgcgtcgatc aagtcaaggc tctcgttgat     2040

caaggtgaca tcatgggggc ccgcacgtac atccagtacg tgcaagacat tatcaccttt     2100

ttgcgcagta acctcgacac gtcgacggaa gcaggcaagg cggccgatgc ggcatacgcg     2160

tacttctata agatgctggt tgagtggttc ctgcagccat cgaaggtgga aagcgagtac     2220

aaggaaatgc gagatttctg gcagtcgtgg gcggacacgt gggccaaggt tgaggcatga     2280


<210>   275
<211>   364
<212>   PRT
<213>   Thermoanaerobacter tengcongensis MB4

<400>   275
Leu Ser Leu Cys Leu Ile Thr Lys Asn Glu Glu Lys Asn Ile Ser Arg 
                5                   10                  15      

Cys Ile Asn Ser Val Lys Asp Ile Val Asp Glu Ile Val Val Val Asp 
            20                  25                  30          

Thr Gly Ser Thr Asp Arg Thr Ile Glu Ile Ala Lys Ser Phe Gly Ala 
        35                  40                  45              

Lys Val Ile Gln Ile Lys Trp Glu Asp Asp Phe Ser Lys Ala Arg Asn 
    50                  55                  60                  

Thr Ala Ile Glu Ser Ala Thr Gly Asp Trp Ile Leu Phe Leu Asp Ala 
65                  70                  75                  80  

Asp Glu Glu Ile Lys Lys Glu Asp Val Ser Lys Ile Lys Ser Leu Leu 
                85                  90                  95      

Tyr Asp Asp Thr Val Glu Ala Tyr Leu Phe Lys Phe Val Asn Tyr Ala 
            100                 105                 110         

Gly Ser Ser Ile Asn Ser Gly Leu Thr Glu Ile Asn Tyr Asn Tyr Arg 
        115                 120                 125             

Leu Phe Arg Asn Asn Gly Lys Leu Lys Tyr Ile Tyr Pro Val His Glu 
    130                 135                 140                 

Asn Leu Arg Asn Ile Glu Glu Asn Arg Pro Pro Ile Ala Lys Lys Ala 
145                 150                 155                 160 

Asp Val Thr Ile Leu His Tyr Gly Tyr Leu Ala Asp Ile Arg Lys Glu 
                165                 170                 175     

Lys Asn Lys Ser Glu Arg Tyr Ile Lys Leu Ile Ser Lys Tyr Leu Glu 
            180                 185                 190         

Ser His Pro Glu Asp Lys Phe Gln His Ala Asn Leu Ala Val Glu Tyr 
        195                 200                 205             

Phe Asn Ile Gly Asp Tyr Gln Lys Ala Leu Lys His Leu Leu Ile Ala 
    210                 215                 220                 

Thr Lys Gly Met Asp Val Asn Ser Val Asn Ala Thr Arg Leu Leu Arg 
225                 230                 235                 240 

Tyr Leu Ile Gly Cys Tyr Ile Gly Leu Lys Asp Tyr Ser Thr Ala Leu 
                245                 250                 255     

Lys Ile Ile Lys Asp Ala Lys Asp Tyr Tyr Lys Asp Ile Pro Asp Phe 
            260                 265                 270         

Ser Phe Leu Glu Gly Leu Met Tyr Met Asp Gln Lys Arg Tyr Glu Lys 
        275                 280                 285             

Ala Ile Glu Ala Phe Lys Glu Ser Leu Ser Ile Gly Glu Tyr Asp Gly 
    290                 295                 300                 

Leu Phe Ile Thr Met Gly Gly Thr Gly Ser Tyr Arg Ala Arg Tyr Met 
305                 310                 315                 320 

Ile Gly Leu Cys Lys Glu Lys Leu Asn Gln Leu Asn Asp Ala Val Lys 
                325                 330                 335     

Glu Tyr Ile Glu Val Leu Lys Glu Asn Pro Asn Tyr Gln Glu Val Phe 
            340                 345                 350         

Ile Lys Leu Phe Asp Leu Phe Ile Lys Asn Glu Pro 
        355                 360                 

<210>   276
<211>   358
<212>   PRT
<213>   Listeria welshimeri serovar 6b str. SLCC5334

<400>   276
Leu Ile Ser Ile Cys Met Ile Val Lys Asn Glu Ala His Ile Leu Arg 
                5                   10                  15      

Gln Ser Leu Ala Ser Phe Arg Lys Phe Thr Glu Glu Ile Ile Ile Val 
            20                  25                  30          

Asp Thr Gly Ser Thr Asp Glu Thr Lys Glu Ile Ala Lys Glu Phe Thr 
        35                  40                  45              

Asp Phe Val Tyr Asp Phe Glu Trp Thr Gly Asn Phe Ser Asp Ala Arg 
    50                  55                  60                  

Asn Phe Ala Ala Lys His Ala Thr Gly Lys Trp Ile Leu Ala Ile Asp 
65                  70                  75                  80  

Ala Asp Glu Cys Leu Glu Glu Glu Ser Tyr Leu Gln Leu Lys Lys Gln 
                85                  90                  95      

Leu Lys Ala Pro Thr Glu Pro Ile Gln Met Ala Gln Ile Ile Ser Phe 
            100                 105                 110         

Thr Gly Glu Lys Gly Arg Val Thr Thr Thr Asn Gln Met Ala Arg Val 
        115                 120                 125             

Tyr Lys Asn Asp Gly Thr Ile Cys Phe Arg Gly Val Ile His Glu Gln 
    130                 135                 140                 

Leu Glu Gly Ile Asp Lys His Ala Val Glu Thr Gly Phe Ala Pro Val 
145                 150                 155                 160 

Lys Ile Tyr His Tyr Gly Tyr Met Ser Glu Ile Val Glu Lys Gln Gly 
                165                 170                 175     

Lys Ser Asp Arg Asn Leu Arg Leu Leu Glu Lys Glu Val Lys Asn Asn 
            180                 185                 190         

Lys Asn Ser Gly Phe Val His Phe Asn Ile Gly Gln Glu Met Asn Arg 
        195                 200                 205             

Leu Gly Asp Lys Lys Glu Ala Leu Lys Glu Phe Thr Lys Ala Phe Arg 
    210                 215                 220                 

Leu Arg Asp Asn Asn Gln Tyr Ile Trp Ala Lys Leu Ser Ala Tyr His 
225                 230                 235                 240 

Ile Ser Glu Leu Leu Glu Gln Glu Lys Arg Tyr Glu Glu Ser Leu Ala 
                245                 250                 255     

Ile Ile Glu Glu Ala Lys Val Ile Trp Pro Asn Val Pro Glu Phe Pro 
            260                 265                 270         

Leu Lys Lys Ala Asn Ile Leu Tyr Leu His His Gln Leu Glu Asp Ala 
        275                 280                 285             

Lys Glu Ile Tyr His Ser Leu Leu Asp Asn Lys Val Ile Asp Tyr Gln 
    290                 295                 300                 

Pro Ile Val Leu Tyr Glu Ala Thr Asn Phe Met Pro His Lys Met Leu 
305                 310                 315                 320 

Gly Thr Ile Tyr Leu Glu Glu Lys Asp Tyr Thr Arg Ala Met Thr His 
                325                 330                 335     

Phe Ser Lys Ala Tyr Ala Glu Asn Ser Ser Asp Tyr Gly Val Met Phe 
            340                 345                 350         

Gln Met Ile Met Leu Leu 
        355             

<210>   277
<211>   345
<212>   PRT
<213>   Bacillus cereus subsp. cytotoxis NVH 391-98

<400>   277
Ile Ser Ala Cys Leu Ile Val Lys Asn Glu Glu Asp Met Leu Arg Lys 
                5                   10                  15      

Cys Leu Glu Ser Leu Gln Gly Gly Val Asp Glu Ile Val Val Val Asp 
            20                  25                  30          

Thr Gly Ser Thr Asp Thr Thr Lys Glu Ile Ala Lys Glu Phe Thr Asp 
        35                  40                  45              

Lys Val Tyr Asp Phe Glu Trp Thr Asn Asp Phe Ala Glu Ala Arg Asn 
    50                  55                  60                  

Phe Ala Ala Ser Lys Ala Ser Gly Glu Trp Ile Leu Ala Ile Asp Ala 
65                  70                  75                  80  

Asp Glu Cys Val Asp Pro Lys Asn Leu Ala Ala Ala Ile Glu Glu Ile 
                85                  90                  95      

Gln Ser His Asp Asn Lys Phe Asp Val Tyr Ala Val Glu Ile Asn Ser 
            100                 105                 110         

Phe Ser Asp Lys Tyr Gly Glu Asn Leu Ser Met Asn His Met Gln Arg 
        115                 120                 125             

Ile Tyr Lys Asn Asn Gly Glu Phe His Phe Ser Gly Ala Ile His Glu 
    130                 135                 140                 

Gln Ile Val Glu Lys Gly Glu Gly Arg Gln Glu Leu Val Phe Ser Ala 
145                 150                 155                 160 

Leu Lys Leu Tyr His Tyr Gly Tyr Leu Pro Asn Val Val Lys Lys Lys 
                165                 170                 175     

Asn Lys Arg Lys Arg Asn Met Asp Ile Leu Lys Lys Ala Leu Lys Ser 
            180                 185                 190         

Asn Asn Asn Asp Gly Phe Thr Tyr Phe Asn Tyr Gly Gln Glu Leu Arg 
        195                 200                 205             

Ser Leu Gly Lys Thr Lys Glu Ala Leu Glu Ser Phe Ile Lys Ala Tyr 
    210                 215                 220                 

Gln Asn Lys Glu Asp Val Tyr Glu Glu Trp Val Ser Arg Cys Leu Tyr 
225                 230                 235                 240 

Phe Ile Val Glu Met Leu Val Glu Leu Lys Arg Tyr Glu Glu Ala Ile 
                245                 250                 255     

Val Ile Ile Asn Asp Ala Glu Glu Val Phe Ser Thr Ala Pro Asp Phe 
            260                 265                 270         

Pro Phe Trp Lys Gly Glu Ile Tyr Phe Lys Gln Lys Arg Phe Asp Asp 
        275                 280                 285             

Ala Lys Glu Val Tyr Thr His Ile Ile Ser Asn Asn Met Ile Tyr Gln 
    290                 295                 300                 

Asn Ala Val Phe Asn Ala Gly Ala Lys Thr Phe Leu Pro His Val Arg 
305                 310                 315                 320 

Leu Gly Glu Ile Tyr Thr Gln Glu Arg Gln His Gln Gln Ala Leu Gln 
                325                 330                 335     

His Tyr Val Glu Ala Leu Asn Glu Asn 
            340                 345 

<210>   278
<211>   358
<212>   PRT
<213>   Listeria innocua Clip11262

<400>   278
Leu Ile Ser Ile Cys Met Ile Val Lys Asn Glu Ala His Ile Leu Arg 
                5                   10                  15      

Gln Ser Leu Ala Ser Phe Arg Lys Phe Thr Glu Glu Ile Ile Ile Val 
            20                  25                  30          

Asp Thr Gly Ser Thr Asp Asp Thr Lys Glu Ile Ala Lys Glu Phe Thr 
        35                  40                  45              

Asp Phe Val Tyr Asp Phe Glu Trp Thr Gly Asn Phe Ser Asp Ala Arg 
    50                  55                  60                  

Asn Phe Ala Ala Lys His Ala Thr Gly Lys Trp Ile Leu Ala Ile Asp 
65                  70                  75                  80  

Ala Asp Glu Cys Leu Glu Glu Glu Ser Tyr Arg Lys Leu Glu Lys Gln 
                85                  90                  95      

Leu Lys Ser Pro Ile Glu Pro Ile Gln Met Ala Gln Ile Ile Ser Phe 
            100                 105                 110         

Thr Gly Glu Lys Gly Arg Val Thr Thr Thr Asn Gln Met Ala Arg Val 
        115                 120                 125             

Tyr Lys Asn Asp Gly Thr Ile Cys Phe Arg Gly Val Ile His Glu Gln 
    130                 135                 140                 

Leu Glu Ala Val Asp Lys His Ala Ile Glu Ala Gly Leu Ala Glu Val 
145                 150                 155                 160 

Lys Ile Tyr His Tyr Gly Tyr Met Ser Glu Ile Val Glu Lys Gln Asp 
                165                 170                 175     

Lys Ser Asp Arg Asn Leu Arg Leu Leu Glu Lys Glu Val Lys Asn Asn 
            180                 185                 190         

Lys Asn Ser Gly Phe Val His Phe Asn Ile Gly Gln Glu Met Asn Arg 
        195                 200                 205             

Leu Gly Asn Lys Lys Glu Ala Leu Lys Glu Phe Ser Glu Ala Phe Arg 
    210                 215                 220                 

Leu Arg Asp Asn Asn His Tyr Ile Trp Ala Lys Leu Ser Ala Tyr His 
225                 230                 235                 240 

Ile Ser Glu Leu Leu Glu Gln Glu Lys Arg Tyr Asp Glu Ser Leu Ala 
                245                 250                 255     

Ile Ile Glu Glu Ala Lys Val Ile Trp Pro Asn Val Pro Glu Phe Pro 
            260                 265                 270         

Leu Lys Lys Ala Asn Ile Leu Tyr Val Asn His Gln Leu Glu Asp Ala 
        275                 280                 285             

Lys Glu Ile Tyr Lys Ser Leu Leu Glu Asn Thr Ala Ile Asp Tyr Gln 
    290                 295                 300                 

Pro Ile Val Leu Tyr Glu Ala Thr Asn Phe Met Pro His Lys Met Leu 
305                 310                 315                 320 

Gly Thr Ile Tyr Leu Glu Glu Lys Asp Tyr Thr Arg Ala Met Thr His 
                325                 330                 335     

Phe Ser Lys Ala Tyr Ala Glu Asn Ser Ser Asp Tyr Gly Val Met Phe 
            340                 345                 350         

Gln Met Ile Met Leu Leu 
        355             

<210>   279
<211>   358
<212>   PRT
<213>   Listeria monocytogenes FSL N3-165

<400>   279
Leu Ile Ser Ile Cys Met Ile Val Lys Asn Glu Ala His Ile Leu Arg 
                5                   10                  15      

Gln Ser Leu Ala Ser Phe Arg Lys Phe Thr Glu Glu Ile Ile Ile Val 
            20                  25                  30          

Asp Thr Gly Ser Thr Asp Glu Thr Lys Glu Ile Ala Gln Glu Phe Thr 
        35                  40                  45              

Asp Phe Val Tyr Asp Phe Glu Trp Thr Gly Asn Phe Ser Asp Ala Arg 
    50                  55                  60                  

Asn Phe Ala Ala Lys His Ala Thr Gly Lys Trp Ile Leu Ala Ile Asp 
65                  70                  75                  80  

Ala Asp Glu Cys Leu Glu Glu Glu Ser Tyr Arg Lys Leu Glu Lys Gln 
                85                  90                  95      

Leu Lys Ser Pro Thr Glu Pro Ile Gln Met Ala Gln Ile Ile Ser Phe 
            100                 105                 110         

Thr Gly Glu Lys Gly Arg Val Thr Thr Thr Asn Gln Met Ala Arg Val 
        115                 120                 125             

Tyr Lys Asn Asp Gly Thr Ile Cys Phe Arg Gly Val Ile His Glu Gln 
    130                 135                 140                 

Leu Glu Ala Ile Asp Lys Arg Pro Ile Ala Ala Gly Val Ala Glu Val 
145                 150                 155                 160 

Lys Ile Tyr His Tyr Gly Tyr Met Ser Glu Ile Val Glu Lys Gln Asp 
                165                 170                 175     

Lys Ser Asp Arg Asn Leu Arg Leu Leu Glu Lys Glu Val Lys Asn Asn 
            180                 185                 190         

Lys Asn Ser Gly Phe Val His Phe Asn Ile Gly Gln Glu Met Asn Arg 
        195                 200                 205             

Leu Gly Asn Lys Lys Glu Ala Leu Lys Glu Phe Ser Glu Ala Phe Arg 
    210                 215                 220                 

Leu Arg Asp His Asn His Tyr Ile Trp Ala Lys Leu Ser Ala Tyr His 
225                 230                 235                 240 

Ile Ala Glu Leu Leu Glu Gln Glu Lys Arg Tyr Asp Glu Ser Leu Ala 
                245                 250                 255     

Ile Ile Glu Glu Ala Arg Val Ile Trp Pro Asn Val Pro Glu Phe Pro 
            260                 265                 270         

Leu Lys Lys Ala Asn Ile Leu Tyr Val Asn His Gln Leu Glu Asp Ala 
        275                 280                 285             

Lys Glu Ile Tyr Gln Ser Leu Leu Glu Asn Ala Ala Ile Asp Tyr Gln 
    290                 295                 300                 

Pro Ile Val Leu Tyr Glu Ala Thr Asn Phe Met Pro His Lys Met Leu 
305                 310                 315                 320 

Gly Thr Ile Tyr Leu Glu Glu Lys Asp Tyr Thr Arg Ala Met Thr His 
                325                 330                 335     

Phe Ser Lys Ala Tyr Ala Glu Asn Ser Ser Asp Tyr Gly Val Met Phe 
            340                 345                 350         

Gln Met Ile Met Leu Leu 
        355             

<210>   280
<211>   759
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 273

<400>   280
Met Arg Arg Ile Val Val Leu Leu Ser Ala Cys Leu Ile Val Lys Asn 
                5                   10                  15      

Glu Ala His Val Leu Pro Arg Cys Leu Gly Ser Leu Gln Gly Val Ala 
            20                  25                  30          

Asp Glu Ile Val Val Val Asp Thr Gly Ser Thr Asp Asp Thr Pro Arg 
        35                  40                  45              

Ile Ala Glu Ser Phe Gly Ala Arg Val Tyr His Phe Glu Trp Thr Gly 
    50                  55                  60                  

Asp Phe Ala Val Ala Arg Asn Glu Ser Leu Arg Tyr Ala Leu Gly Glu 
65                  70                  75                  80  

Tyr Val Leu Val Ile Asp Ala Asp Glu Phe Leu Pro Lys Glu Asp Gly 
                85                  90                  95      

Val Arg Leu Arg Gln Ala Leu Gln Glu Arg Arg Ala Asp Ala Tyr Thr 
            100                 105                 110         

Val Asp Leu Val Asn Tyr Leu Gly Ser Val Ala Arg Phe Val Arg Ser 
        115                 120                 125             

Pro Gly Val Arg Val Val Arg Val Phe Arg Arg Gly Phe Ser Tyr Met 
    130                 135                 140                 

Gly Ser Ile His Glu Gln Ile Leu Tyr Asp Val Ile Ala Lys Gly Gly 
145                 150                 155                 160 

Gln Ile Glu Val Leu Asp Val Glu Ile His His Leu Gly Tyr Leu Ala 
                165                 170                 175     

Glu Phe Val Ala Leu Lys Gly Lys Ser Asp Arg Asn Leu Glu Ile Leu 
            180                 185                 190         

Asn Gln Ala Leu Ala Ile Asp Pro Asp Asn Phe Phe His Ile Thr Asn 
        195                 200                 205             

Leu Met Ala Glu Tyr Ala Arg Leu Gly Asp Pro Lys Lys Val Val Glu 
    210                 215                 220                 

Leu Gly Glu Arg Ala Tyr Asp Leu Phe Gln Arg Gly Arg Val Asn Gln 
225                 230                 235                 240 

Pro His Leu Val Leu Arg Met Tyr Arg Met Met Ile Ala Ala His Gly 
                245                 250                 255     

Asp Leu Gly Asn Tyr Asp Arg Val Glu Ala Leu Ala Arg Glu Ala Glu 
            260                 265                 270         

Leu Phe Phe Pro Asn Ile Pro Asp Val Pro Phe Val His Ala Leu Tyr 
        275                 280                 285             

Val Met Gln Arg Gly Asp Trp Arg Lys Ala Ile Arg Leu Phe Glu Arg 
    290                 295                 300                 

Ser Arg Glu Ile Gly Glu Ile Arg Ser Glu Ile Ile Asp Thr Ile Ala 
305                 310                 315                 320 

Gly Ala Gly Ser Tyr Val Ala Ala Ala Lys Leu Gly Glu Leu Trp Leu 
                325                 330                 335     

Leu Glu Gly Asp Val Glu Leu Ala Arg Glu Tyr Phe Val Gln Ser Leu 
            340                 345                 350         

Arg Glu Asn Leu Arg Gln Glu Gly Thr Phe Phe Phe Leu Ala Ser Leu 
        355                 360                 365             

Leu Pro Leu Asn Asp Pro Ser Val Phe Glu Gln Leu Arg Ala Leu Ala 
    370                 375                 380                 

Ser His Asp Pro Val Cys Leu Ala Tyr Leu Ala Leu Ala Gly Ala Val 
385                 390                 395                 400 

Trp Arg Val Asp His Ala Trp Arg Leu Ile Asn Glu Ile Glu Gln Thr 
                405                 410                 415     

Pro Val Thr Ala Pro Ile Val Ala Lys Leu Arg Ala Leu Gly Ala Val 
            420                 425                 430         

Leu Gly Ile Leu Pro Ala Asn Asp Val Arg Val Asp Ser Thr Val Glu 
        435                 440                 445             

Arg Glu Ile Gln Trp Tyr Glu Ala Leu Phe Ala Leu Glu Arg Gly Asp 
    450                 455                 460                 

Arg Asp Gln Ala Glu Arg Cys Leu Arg Asp Asn Pro Glu Arg Trp Glu 
465                 470                 475                 480 

Arg Leu Ser Glu Trp Leu Thr Ser Lys Gln Gly Leu Cys Ile Ser Pro 
                485                 490                 495     

Ile Leu Asp Glu Leu Leu Leu Ala Arg Val Asp Glu Leu Leu Leu Ala 
            500                 505                 510         

Trp Leu Pro Arg Ala Glu Asp Arg Asp Leu Ala Leu Ser Arg Val Leu 
        515                 520                 525             

Ala Ser Pro Leu Arg Glu Glu Val Trp Lys Ala Ala Trp Leu Gly Glu 
    530                 535                 540                 

Arg Gly Trp Glu Cys Asp Phe Leu Ala Leu Gly Ala Phe Arg Arg Arg 
545                 550                 555                 560 

Asp Ile Gln Ala Ser Leu Asn Trp Leu Glu Arg Gly Leu Thr Tyr Glu 
                565                 570                 575     

Pro Thr Val Arg Arg Ala Ile Val Glu Ile Asp Leu Ala Leu Cys His 
            580                 585                 590         

Lys Asn Ile Ala His Ala Gln Glu Val Ala Ser Gln Ala Ser Arg Leu 
        595                 600                 605             

Phe Pro Glu Ser Lys Leu Leu Glu Gly Ile Ala Gly Ser Leu Gly Val 
    610                 615                 620                 

Ser Pro Arg Pro Met Arg Ser Leu Asp Asp Leu Leu Gly Gly Gly Ser 
625                 630                 635                 640 

Gly Leu Asn Pro His Arg Ala Tyr Gln Ser Ser Val Asn Ser Met Pro 
                645                 650                 655     

Leu Lys Val Lys Ile Met Lys Leu His Glu Arg Ala Val Glu Cys Val 
            660                 665                 670         

Asp Gln Val Lys Ala Leu Val Asp Gln Gly Asp Ile Met Gly Ala Arg 
        675                 680                 685             

Thr Tyr Ile Gln Tyr Val Gln Asp Ile Ile Thr Phe Leu Arg Ser Asn 
    690                 695                 700                 

Leu Asp Thr Ser Thr Glu Ala Gly Lys Ala Ala Asp Ala Ala Tyr Ala 
705                 710                 715                 720 

Tyr Phe Tyr Lys Met Leu Val Glu Trp Phe Leu Gln Pro Ser Lys Val 
                725                 730                 735     

Glu Ser Glu Tyr Lys Glu Met Arg Asp Phe Trp Gln Ser Trp Ala Asp 
            740                 745                 750         

Thr Trp Ala Lys Val Glu Ala 
        755                 

<210>   281
<211>   759
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 273

<400>   281
Met Arg Arg Ile Val Val Leu Leu Ser Ala Cys Leu Ile Val Lys Asn 
                5                   10                  15      

Glu Ala His Val Leu Pro Arg Cys Leu Gly Ser Leu Gln Gly Val Ala 
            20                  25                  30          

Asp Glu Ile Val Val Val Asp Thr Gly Ser Thr Asp Asp Thr Pro Arg 
        35                  40                  45              

Ile Ala Glu Ser Phe Gly Ala Arg Val Tyr His Phe Glu Trp Thr Gly 
    50                  55                  60                  

Asp Phe Ala Val Ala Arg Asn Glu Ser Leu Arg Tyr Ala Leu Gly Glu 
65                  70                  75                  80  

Tyr Val Leu Val Ile Asp Ala Asp Glu Phe Leu Pro Lys Glu Asp Gly 
                85                  90                  95      

Val Arg Leu Arg Gln Ala Leu Gln Glu Arg Arg Ala Asp Ala Tyr Thr 
            100                 105                 110         

Val Asp Leu Val Asn Tyr Leu Gly Ser Val Ala Arg Phe Val Arg Ser 
        115                 120                 125             

Pro Gly Val Arg Val Val Arg Val Phe Arg Arg Gly Phe Ser Tyr Met 
    130                 135                 140                 

Gly Ser Ile His Glu Gln Ile Leu Tyr Asp Val Ile Ala Lys Gly Gly 
145                 150                 155                 160 

Gln Ile Glu Val Leu Asp Val Glu Ile His His Leu Gly Tyr Leu Ala 
                165                 170                 175     

Glu Phe Val Ala Leu Lys Gly Lys Ser Asp Arg Asn Leu Glu Ile Leu 
            180                 185                 190         

Asn Gln Ala Leu Ala Ile Asp Pro Asp Asn Phe Phe His Ile Thr Asn 
        195                 200                 205             

Leu Met Ala Glu Tyr Ala Arg Leu Gly Asp Pro Lys Lys Val Val Glu 
    210                 215                 220                 

Leu Gly Glu Arg Ala Tyr Asp Leu Phe Gln Arg Gly Arg Val Asn Gln 
225                 230                 235                 240 

Pro His Leu Val Leu Arg Met Tyr Arg Met Met Ile Ala Ala His Gly 
                245                 250                 255     

Asp Leu Gly Asn Tyr Asp Arg Val Glu Ala Leu Ala Arg Glu Ala Glu 
            260                 265                 270         

Leu Phe Phe Pro Asn Ile Pro Asp Val Pro Phe Val His Ala Leu Tyr 
        275                 280                 285             

Val Met Gln Arg Gly Asp Trp Arg Lys Ala Ile Arg Leu Phe Glu Arg 
    290                 295                 300                 

Ser Arg Glu Ile Gly Glu Ile Arg Ser Glu Ile Ile Asp Thr Ile Ala 
305                 310                 315                 320 

Gly Ala Gly Ser Tyr Val Ala Ala Ala Lys Leu Gly Glu Leu Trp Leu 
                325                 330                 335     

Leu Glu Gly Asp Val Glu Leu Ala Arg Glu Tyr Phe Val Gln Ser Leu 
            340                 345                 350         

Arg Glu Asn Leu Arg Gln Glu Gly Thr Phe Phe Phe Leu Ala Ser Leu 
        355                 360                 365             

Leu Pro Leu Asn Asp Pro Ser Val Phe Glu Gln Leu Arg Ala Leu Ala 
    370                 375                 380                 

Ser His Asp Pro Val Cys Leu Ala Tyr Leu Ala Leu Ala Gly Ala Ile 
385                 390                 395                 400 

Trp Arg Val Asp His Ala Trp Arg Leu Ile Asn Glu Ile Glu Gln Thr 
                405                 410                 415     

Pro Val Thr Ala Pro Ile Val Ala Lys Leu Arg Ala Leu Gly Ala Val 
            420                 425                 430         

Leu Gly Ile Leu Pro Ala Asn Asp Val Arg Val Asp Ser Thr Val Glu 
        435                 440                 445             

Arg Glu Ile Gln Trp Tyr Glu Ala Leu Phe Ala Leu Glu Arg Gly Asp 
    450                 455                 460                 

Arg Asp Gln Ala Glu Arg Cys Leu Arg Asp Gln Pro Glu Arg Trp Glu 
465                 470                 475                 480 

Arg Leu Ser Glu Trp Leu Thr Ser Lys Gln Gly Leu Cys Ile Ser Pro 
                485                 490                 495     

Ile Leu Asp Glu Leu Leu Leu Ala Arg Val Asp Glu Leu Leu Leu Ala 
            500                 505                 510         

Trp Leu Pro Arg Ala Glu Asp Arg Asp Leu Ala Leu Ser Arg Val Leu 
        515                 520                 525             

Ala Ser Pro Leu Arg Glu Glu Val Trp Lys Ala Ala Trp Leu Gly Glu 
    530                 535                 540                 

Arg Gly Trp Glu Cys Asp Phe Leu Ala Leu Gly Ala Phe Arg Arg Arg 
545                 550                 555                 560 

Asp Ile Gln Ala Ser Leu Asn Trp Leu Glu Arg Gly Leu Thr Tyr Glu 
                565                 570                 575     

Pro Thr Val Arg Arg Ala Ile Val Glu Ile Asp Leu Ala Leu Cys His 
            580                 585                 590         

Lys Asn Ile Ala His Ala Gln Glu Val Ala Ser Gln Ala Ser Arg Leu 
        595                 600                 605             

Phe Pro Glu Ser Lys Leu Leu Glu Gly Ile Ala Gly Ser Leu Gly Val 
    610                 615                 620                 

Ser Pro Arg Pro Met Arg Ser Leu Asp Asp Leu Leu Gly Gly Gly Ser 
625                 630                 635                 640 

Gly Leu Asn Pro His Arg Ala Tyr Gln Ser Ser Val Asn Ser Met Pro 
                645                 650                 655     

Leu Lys Val Lys Ile Met Lys Leu His Glu Arg Ala Val Glu Cys Val 
            660                 665                 670         

Asp Gln Val Lys Ala Leu Val Asp Gln Gly Asp Ile Met Gly Ala Arg 
        675                 680                 685             

Thr Tyr Ile Gln Tyr Val Gln Asp Ile Ile Thr Phe Leu Arg Ser Asn 
    690                 695                 700                 

Leu Asp Thr Ser Thr Glu Ala Gly Lys Ala Ala Asp Ala Ala Tyr Ala 
705                 710                 715                 720 

Tyr Phe Tyr Lys Met Leu Val Glu Trp Phe Leu Gln Pro Ser Lys Val 
                725                 730                 735     

Glu Ser Glu Tyr Lys Glu Met Arg Asp Phe Trp Gln Ser Trp Ala Asp 
            740                 745                 750         

Thr Trp Ala Lys Val Glu Ala 
        755                 

<210>   282
<211>   759
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 273

<400>   282
Met Arg Arg Ile Val Val Leu Leu Ser Ala Cys Leu Ile Val Lys Asn 
                5                   10                  15      

Glu Ala His Val Leu Pro Arg Cys Leu Gly Ser Leu Gln Gly Val Ala 
            20                  25                  30          

Asp Glu Ile Val Val Val Asp Thr Gly Ser Thr Asp Asp Thr Pro Arg 
        35                  40                  45              

Ile Ala Glu Ser Phe Gly Ala Arg Val Tyr His Phe Glu Trp Thr Gly 
    50                  55                  60                  

Asp Phe Ala Val Ala Arg Asn Glu Ser Leu Arg Tyr Ala Leu Gly Glu 
65                  70                  75                  80  

Tyr Val Leu Val Ile Asp Ala Asp Glu Phe Leu Pro Lys Glu Asp Gly 
                85                  90                  95      

Val Arg Leu Arg Gln Ala Leu Gln Glu Arg Arg Ala Asp Ala Tyr Thr 
            100                 105                 110         

Val Asp Leu Val Asn Tyr Leu Gly Ser Val Ala Arg Phe Val Arg Ser 
        115                 120                 125             

Pro Gly Val Arg Val Val Arg Val Phe Arg Arg Gly Phe Ser Tyr Met 
    130                 135                 140                 

Gly Ser Ile His Glu Gln Ile Leu Tyr Asp Val Ile Ala Lys Gly Gly 
145                 150                 155                 160 

Gln Ile Glu Val Leu Asp Val Glu Ile His His Leu Gly Tyr Leu Ala 
                165                 170                 175     

Glu Phe Val Ala Leu Lys Gly Lys Ser Asp Arg Asn Leu Glu Ile Leu 
            180                 185                 190         

Asn Gln Ala Leu Ala Ile Asp Pro Asp Asn Phe Phe His Ile Thr Asn 
        195                 200                 205             

Leu Met Ala Glu Tyr Ala Arg Leu Gly Asp Pro Lys Lys Val Val Glu 
    210                 215                 220                 

Leu Gly Glu Arg Ala Tyr Asp Leu Phe Gln Arg Gly Arg Val Asn Gln 
225                 230                 235                 240 

Pro His Leu Val Leu Arg Met Tyr Arg Met Met Ile Ala Ala His Gly 
                245                 250                 255     

Asp Leu Gly Asn Tyr Asp Arg Val Glu Ala Leu Ala Arg Glu Ala Glu 
            260                 265                 270         

Leu Phe Phe Pro Asn Ile Pro Asp Val Pro Phe Val His Ala Leu Tyr 
        275                 280                 285             

Val Met Gln Arg Gly Asp Trp Arg Lys Ala Ile Arg Leu Phe Glu Arg 
    290                 295                 300                 

Ser Arg Glu Ile Gly Glu Ile Arg Ser Glu Ile Ile Asp Thr Ile Ala 
305                 310                 315                 320 

Gly Ala Gly Ser Tyr Val Ala Ala Ala Lys Leu Gly Glu Leu Trp Leu 
                325                 330                 335     

Leu Asp Gly Asp Val Glu Leu Ala Arg Glu Tyr Phe Val Gln Ser Leu 
            340                 345                 350         

Arg Glu Asn Leu Arg Gln Glu Gly Thr Phe Phe Phe Leu Ala Ser Leu 
        355                 360                 365             

Leu Pro Leu Asn Asp Pro Ser Val Phe Glu Gln Leu Arg Ala Leu Ala 
    370                 375                 380                 

Ser His Asp Pro Val Cys Leu Ala Tyr Leu Ala Leu Ala Gly Ala Val 
385                 390                 395                 400 

Trp Arg Val Asp His Ala Trp Arg Leu Ile Asn Glu Ile Glu Gln Thr 
                405                 410                 415     

Pro Val Thr Ala Pro Ile Val Ala Lys Leu Arg Ala Leu Gly Ala Val 
            420                 425                 430         

Leu Gly Ile Leu Pro Ala Asn Asp Val Arg Val Asp Ser Thr Val Glu 
        435                 440                 445             

Arg Glu Ile Gln Trp Tyr Glu Ala Leu Phe Ala Leu Glu Arg Gly Asp 
    450                 455                 460                 

Arg Asp Gln Ala Glu Arg Cys Leu Arg Asp Gln Pro Glu Arg Trp Glu 
465                 470                 475                 480 

Arg Leu Ser Glu Trp Leu Thr Ser Lys Gln Gly Leu Cys Ile Ser Pro 
                485                 490                 495     

Ile Leu Asp Glu Leu Leu Leu Ala Arg Val Asp Glu Leu Leu Leu Ala 
            500                 505                 510         

Trp Leu Pro Arg Ala Glu Asp Arg Asp Leu Ala Leu Ser Arg Val Leu 
        515                 520                 525             

Ala Ser Pro Leu Arg Glu Glu Val Trp Lys Ala Ala Trp Leu Gly Glu 
    530                 535                 540                 

Arg Gly Trp Glu Cys Asp Phe Leu Ala Leu Gly Ala Phe Arg Arg Arg 
545                 550                 555                 560 

Asp Ile Gln Ala Ser Leu Asn Trp Leu Glu Arg Gly Leu Thr Tyr Glu 
                565                 570                 575     

Pro Thr Val Arg Arg Ala Ile Val Glu Ile Asp Leu Ala Leu Cys His 
            580                 585                 590         

Lys Asn Ile Ala His Ala Gln Glu Val Ala Ser Gln Ala Ser Arg Leu 
        595                 600                 605             

Phe Pro Glu Ser Lys Leu Leu Glu Gly Ile Ala Gly Ser Leu Gly Val 
    610                 615                 620                 

Ser Pro Arg Pro Met Arg Ser Leu Asp Asp Leu Leu Gly Gly Gly Ser 
625                 630                 635                 640 

Gly Leu Asn Pro His Arg Ala Tyr Gln Ser Ser Val Asn Ser Met Pro 
                645                 650                 655     

Leu Lys Val Lys Ile Met Lys Leu His Glu Arg Ala Val Glu Cys Val 
            660                 665                 670         

Asp Gln Val Lys Ala Leu Val Asp Gln Gly Asp Ile Met Gly Ala Arg 
        675                 680                 685             

Thr Tyr Ile Gln Tyr Val Gln Asp Ile Ile Thr Phe Leu Arg Ser Asn 
    690                 695                 700                 

Leu Asp Thr Ser Thr Glu Ala Gly Lys Ala Ala Asp Ala Ala Tyr Ala 
705                 710                 715                 720 

Tyr Phe Tyr Lys Met Leu Val Glu Trp Phe Leu Gln Pro Ser Lys Val 
                725                 730                 735     

Glu Ser Glu Tyr Lys Glu Met Arg Asp Phe Trp Gln Ser Trp Ala Asp 
            740                 745                 750         

Thr Trp Ala Lys Val Glu Ala 
        755                 

<210>   283
<211>   759
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 273

<400>   283
Met Arg Arg Ile Val Val Leu Leu Ser Ala Cys Leu Ile Val Lys Asn 
                5                   10                  15      

Glu Ala His Val Leu Pro Arg Cys Leu Gly Ser Leu Gln Gly Val Ala 
            20                  25                  30          

Asp Glu Ile Val Val Val Asp Thr Gly Ser Thr Asp Asp Thr Pro Arg 
        35                  40                  45              

Ile Ala Glu Ser Phe Gly Ala Arg Val Tyr His Phe Glu Trp Thr Gly 
    50                  55                  60                  

Asp Phe Ala Val Ala Arg Asn Glu Ser Leu Arg Tyr Ala Leu Gly Glu 
65                  70                  75                  80  

Tyr Val Leu Val Ile Asp Ala Asp Glu Phe Leu Pro Lys Glu Asp Gly 
                85                  90                  95      

Val Arg Leu Arg Gln Ala Leu Gln Glu Arg Arg Ala Asp Ala Tyr Thr 
            100                 105                 110         

Val Asp Leu Val Asn Tyr Leu Gly Ser Val Ala Arg Phe Val Arg Ser 
        115                 120                 125             

Pro Gly Val Arg Val Val Arg Val Phe Arg Arg Gly Phe Ser Tyr Met 
    130                 135                 140                 

Gly Ser Ile His Glu Gln Ile Leu Tyr Asp Val Ile Ala Lys Gly Gly 
145                 150                 155                 160 

Gln Ile Glu Val Leu Asp Val Glu Ile His His Leu Gly Tyr Leu Ala 
                165                 170                 175     

Glu Phe Val Ala Leu Lys Gly Lys Ser Asp Arg Asn Leu Glu Ile Leu 
            180                 185                 190         

Asn Gln Ala Leu Ala Ile Asp Pro Asp Asn Phe Phe His Ile Thr Asn 
        195                 200                 205             

Leu Met Ala Glu Tyr Ala Arg Leu Gly Asp Pro Lys Lys Val Val Glu 
    210                 215                 220                 

Leu Gly Glu Arg Ala Tyr Asp Leu Phe Gln Arg Gly Arg Val Asn Gln 
225                 230                 235                 240 

Pro His Leu Val Leu Arg Met Tyr Arg Met Met Ile Ala Ala His Gly 
                245                 250                 255     

Asp Leu Gly Asn Tyr Asp Arg Val Glu Ala Leu Ala Arg Glu Ala Glu 
            260                 265                 270         

Leu Phe Phe Pro Asn Ile Pro Asp Val Pro Phe Val His Ala Leu Tyr 
        275                 280                 285             

Val Met Gln Arg Gly Asp Trp Arg Lys Ala Ile Arg Leu Phe Glu Arg 
    290                 295                 300                 

Ser Arg Glu Ile Gly Glu Ile Arg Ser Glu Ile Ile Asp Thr Ile Ala 
305                 310                 315                 320 

Gly Ala Gly Ser Tyr Val Ala Ala Ala Lys Leu Gly Glu Leu Trp Leu 
                325                 330                 335     

Leu Glu Gly Asp Val Glu Leu Ala Arg Glu Tyr Phe Val Gln Ser Leu 
            340                 345                 350         

Arg Glu Asn Leu Arg Gln Glu Gly Thr Phe Phe Phe Leu Ala Ser Leu 
        355                 360                 365             

Leu Pro Leu Asn Asp Pro Ser Val Phe Glu Gln Leu Lys Ala Leu Ala 
    370                 375                 380                 

Ser His Asp Pro Val Cys Leu Ala Tyr Leu Ala Leu Ala Gly Ala Val 
385                 390                 395                 400 

Trp Arg Val Asp His Ala Trp Arg Leu Ile Asn Glu Ile Glu Gln Thr 
                405                 410                 415     

Pro Val Thr Ala Pro Ile Val Ala Lys Leu Arg Ala Leu Gly Ala Val 
            420                 425                 430         

Leu Gly Ile Leu Pro Ala Asn Asp Val Arg Val Asp Ser Thr Val Glu 
        435                 440                 445             

Arg Glu Ile Gln Trp Tyr Glu Ala Leu Phe Ala Leu Glu Arg Gly Asp 
    450                 455                 460                 

Arg Asp Gln Ala Glu Arg Cys Leu Arg Asp Gln Pro Glu Arg Trp Glu 
465                 470                 475                 480 

Arg Leu Ser Glu Trp Leu Thr Ser Lys Gln Gly Leu Cys Ile Ser Pro 
                485                 490                 495     

Ile Leu Asp Glu Leu Leu Leu Ala Arg Val Asp Glu Leu Leu Leu Ala 
            500                 505                 510         

Trp Leu Pro Arg Ala Glu Asp Arg Asp Leu Ala Leu Ser Arg Val Leu 
        515                 520                 525             

Ala Ser Pro Leu Arg Glu Glu Val Trp Lys Ala Ala Trp Leu Gly Glu 
    530                 535                 540                 

Arg Gly Trp Glu Cys Asp Phe Leu Ala Leu Gly Ala Phe Arg Arg Arg 
545                 550                 555                 560 

Asp Ile Gln Ala Ser Leu Asn Trp Leu Glu Arg Gly Leu Thr Tyr Glu 
                565                 570                 575     

Pro Thr Val Arg Arg Ala Ile Val Glu Ile Asp Leu Ala Leu Cys His 
            580                 585                 590         

Lys Asn Ile Ala His Ala Gln Glu Val Ala Ser Gln Ala Ser Arg Leu 
        595                 600                 605             

Phe Pro Glu Ser Lys Leu Leu Glu Gly Ile Ala Gly Ser Leu Gly Val 
    610                 615                 620                 

Ser Pro Arg Pro Met Arg Ser Leu Asp Asp Leu Leu Gly Gly Gly Ser 
625                 630                 635                 640 

Gly Leu Asn Pro His Arg Ala Tyr Gln Ser Ser Val Asn Ser Met Pro 
                645                 650                 655     

Leu Lys Val Lys Ile Met Lys Leu His Glu Arg Ala Val Glu Cys Val 
            660                 665                 670         

Asp Gln Val Lys Ala Leu Val Asp Gln Gly Asp Ile Met Gly Ala Arg 
        675                 680                 685             

Thr Tyr Ile Gln Tyr Val Gln Asp Ile Ile Thr Phe Leu Arg Ser Asn 
    690                 695                 700                 

Leu Asp Thr Ser Thr Glu Ala Gly Lys Ala Ala Asp Ala Ala Tyr Ala 
705                 710                 715                 720 

Tyr Phe Tyr Lys Met Leu Val Glu Trp Phe Leu Gln Pro Ser Lys Val 
                725                 730                 735     

Glu Ser Glu Tyr Lys Glu Met Arg Asp Phe Trp Gln Ser Trp Ala Asp 
            740                 745                 750         

Thr Trp Ala Lys Val Glu Ala 
        755                 

<210>   284
<211>   759
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 273

<400>   284
Met Arg Arg Ile Val Val Leu Leu Ser Ala Cys Leu Ile Val Lys Asn 
                5                   10                  15      

Glu Ala His Val Leu Pro Arg Cys Leu Gly Ser Leu Gln Gly Val Ala 
            20                  25                  30          

Asp Glu Ile Val Val Val Asp Thr Gly Ser Thr Asp Asp Thr Pro Arg 
        35                  40                  45              

Ile Ala Glu Ser Phe Gly Ala Arg Val Tyr His Phe Glu Trp Thr Gly 
    50                  55                  60                  

Asp Phe Ala Val Ala Arg Asn Glu Ser Leu Arg Tyr Ala Leu Gly Glu 
65                  70                  75                  80  

Tyr Val Leu Val Ile Asp Ala Asp Glu Phe Leu Pro Lys Glu Asp Gly 
                85                  90                  95      

Val Arg Leu Arg Gln Ala Leu Gln Glu Arg Arg Ala Asp Ala Tyr Thr 
            100                 105                 110         

Val Asp Leu Val Asn Tyr Leu Gly Ser Val Ala Arg Phe Val Arg Ser 
        115                 120                 125             

Pro Gly Val Arg Val Val Arg Val Phe Arg Arg Gly Phe Ser Tyr Met 
    130                 135                 140                 

Gly Ser Ile His Glu Gln Ile Leu Tyr Asp Val Ile Ala Lys Gly Gly 
145                 150                 155                 160 

Asn Ile Glu Val Leu Asp Val Glu Ile His His Leu Gly Tyr Leu Ala 
                165                 170                 175     

Glu Phe Val Ala Leu Lys Gly Lys Ser Asp Arg Asn Leu Glu Ile Leu 
            180                 185                 190         

Asn Gln Ala Leu Ala Ile Asp Pro Asp Asn Phe Phe His Ile Thr Asn 
        195                 200                 205             

Leu Met Ala Glu Tyr Ala Arg Leu Gly Asp Pro Lys Lys Val Val Glu 
    210                 215                 220                 

Leu Gly Glu Arg Ala Tyr Asp Leu Phe Gln Arg Gly Arg Val Asn Gln 
225                 230                 235                 240 

Pro His Leu Val Leu Arg Met Tyr Arg Met Met Ile Ala Ala His Gly 
                245                 250                 255     

Asp Leu Gly Asn Tyr Asp Arg Val Glu Ala Leu Ala Arg Glu Ala Glu 
            260                 265                 270         

Leu Phe Phe Pro Asn Ile Pro Asp Val Pro Phe Val His Ala Leu Tyr 
        275                 280                 285             

Val Met Gln Arg Gly Asp Trp Arg Lys Ala Ile Arg Leu Phe Glu Arg 
    290                 295                 300                 

Ser Arg Glu Ile Gly Glu Ile Arg Ser Glu Ile Ile Asp Thr Ile Ala 
305                 310                 315                 320 

Gly Ala Gly Ser Tyr Val Ala Ala Ala Lys Leu Gly Glu Leu Trp Leu 
                325                 330                 335     

Leu Glu Gly Asp Val Glu Leu Ala Arg Glu Tyr Phe Val Gln Ser Leu 
            340                 345                 350         

Arg Glu Asn Leu Arg Gln Glu Gly Thr Phe Phe Phe Leu Ala Ser Leu 
        355                 360                 365             

Leu Pro Leu Asn Asp Pro Ser Val Phe Glu Gln Leu Arg Ala Leu Ala 
    370                 375                 380                 

Ser His Asp Pro Val Cys Leu Ala Tyr Leu Ala Leu Ala Gly Ala Val 
385                 390                 395                 400 

Trp Arg Val Asp His Ala Trp Arg Leu Ile Asn Glu Ile Glu Gln Thr 
                405                 410                 415     

Pro Val Thr Ala Pro Ile Val Ala Lys Leu Arg Ala Leu Gly Ala Val 
            420                 425                 430         

Leu Gly Ile Leu Pro Ala Asn Asp Val Arg Val Asp Ser Thr Val Glu 
        435                 440                 445             

Arg Glu Ile Gln Trp Tyr Glu Ala Leu Phe Ala Leu Glu Arg Gly Asp 
    450                 455                 460                 

Arg Asp Gln Ala Glu Arg Cys Leu Arg Asp Gln Pro Glu Arg Trp Glu 
465                 470                 475                 480 

Arg Leu Ser Glu Trp Leu Thr Ser Lys Gln Gly Leu Cys Ile Ser Pro 
                485                 490                 495     

Ile Leu Asp Glu Leu Leu Leu Ala Arg Val Asp Glu Leu Leu Leu Ala 
            500                 505                 510         

Trp Leu Pro Arg Ala Glu Asp Arg Asp Leu Ala Leu Ser Arg Val Leu 
        515                 520                 525             

Ala Ser Pro Leu Arg Glu Glu Val Trp Lys Ala Ala Trp Leu Gly Glu 
    530                 535                 540                 

Arg Gly Trp Glu Cys Asp Phe Leu Ala Leu Gly Ala Phe Arg Arg Arg 
545                 550                 555                 560 

Asp Ile Gln Ala Ser Leu Asn Trp Leu Glu Arg Gly Leu Thr Tyr Glu 
                565                 570                 575     

Pro Thr Val Arg Arg Ala Ile Val Glu Ile Asp Leu Ala Leu Cys His 
            580                 585                 590         

Lys Asn Ile Ala His Ala Gln Glu Val Ala Ser Gln Ala Ser Arg Leu 
        595                 600                 605             

Phe Pro Glu Ser Lys Leu Leu Glu Gly Ile Ala Gly Ser Leu Gly Val 
    610                 615                 620                 

Ser Pro Arg Pro Met Arg Ser Leu Asp Asp Leu Leu Gly Gly Gly Ser 
625                 630                 635                 640 

Gly Leu Asn Pro His Arg Ala Tyr Gln Ser Ser Val Asn Ser Met Pro 
                645                 650                 655     

Leu Lys Val Lys Ile Met Lys Leu His Glu Arg Ala Val Glu Cys Val 
            660                 665                 670         

Asp Gln Val Lys Ala Leu Val Asp Gln Gly Asp Ile Met Gly Ala Arg 
        675                 680                 685             

Thr Tyr Ile Gln Tyr Val Gln Asp Ile Ile Thr Phe Leu Arg Ser Asn 
    690                 695                 700                 

Leu Asp Thr Ser Thr Glu Ala Gly Lys Ala Ala Asp Ala Ala Tyr Ala 
705                 710                 715                 720 

Tyr Phe Tyr Lys Met Leu Val Glu Trp Phe Leu Gln Pro Ser Lys Val 
                725                 730                 735     

Glu Ser Glu Tyr Lys Glu Met Arg Asp Phe Trp Gln Ser Trp Ala Asp 
            740                 745                 750         

Thr Trp Ala Lys Val Glu Ala 
        755                 

<210>   285
<211>   2280
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 274

<400>   285
gtgaggagaa tcgtcgtgct actttcggcc tgtctcatag tgaaaaacga agctcatgtg       60

ctaccgcgtt gcttaggttc gctccaaggc gtagcagatg aaatcgtggt agtagacaca      120

ggttctacgg atgacactcc tcgcatcgcc gagtcattcg gtgcgcgtgt gtatcatttt      180

gagtggactg gagactttgc ggtagcccga aacgaatcgt tgcgatatgc gctgggcgag      240

tatgtgcttg tgatcgatgc tgatgagttt ttgccaaagg aggacggtgt tcgcctgcgt      300

caggcgctcc aagagaggcg ggccgacgct tatactgtgg acctcgtcaa ctacttagga      360

tcagtggctc gttttgtccg ttcacccggt gttcgcgtgg tgcgcgtctt tcgacgcggt      420

ttctcgtaca tgggttctat ccacgaacaa attttgtacg acgtgatcgc caaaggcggt      480

caaatcgagg ttcttgacgt cgagattcat catttaggtt atctagccga gttcgtagcg      540

cttaaaggca agtcggaccg caatctcgag atcttaaatc aggccctggc aattgatccg      600

gataattttt ttcatatcac gaaccttatg gccgaatacg cccggttagg tgatccaaaa      660

aaagtcgtgg agctgggcga gcgcgcatac gacctttttc agcgcggtcg agttaaccag      720

ccgcatctcg ttctgcgaat gtatcgcatg atgatcgcag cgcacggcga tcttggcaat      780

tatgaccgag tcgaggcact ggcgagagaa gccgagctat tctttccgaa tatcccggac      840

gtcccattcg tccatgcact ctatgtgatg caacgcggcg attggcgaaa ggcgattcgg      900

ctgtttgagc gcagtcgtga aattggtgag attcgatctg agattatcga caccatagct      960

ggcgcgggct catacgtcgc ggctgcgaag ctcggcgaac tctggctact cgagggcgat     1020

gtagaacttg ctcgagaata ttttgtacag agtttacgtg agaacctgcg tcaggagggc     1080

accttctttt tcttagcttc gcttctcccg ctgaatgatc caagcgtatt cgagcaactc     1140

cgtgccctcg cgagccacga tccagtctgt cttgcgtatc ttgccctcgc aggagcagta     1200

tggcgggtcg accatgcttg gcggctcatc aatgaaatcg aacaaacgcc cgtgacggca     1260

ccaatcgtcg caaaactgcg cgcactcggc gcggtacttg gtattctacc cgcaaacgat     1320

gtccgagtgg attcgacggt cgaacgggaa attcaatggt acgaggcgct ctttgcactt     1380

gaacgaggag atcgcgacca ggcagagaga tgcctacgcg acaatccgga gcgttgggag     1440

cgtctgtctg agtggctaac gagcaagcaa ggtctttgca ttagcccgat cctggacgag     1500

ttgctgctag ctcgtgtcga tgagttgctt cttgcgtggc taccaagggc agaagaccga     1560

gatctcgcgc tgtcaagggt tttggcgtct ccgcttcgcg aggaagtctg gaaggctgcg     1620

tggctcggcg aacgcggctg ggagtgcgac tttttggcct tgggtgcgtt tcggcgccgc     1680

gacattcagg caagtctcaa ctggctcgag cgtggtctca cctacgagcc cacagtacgg     1740

cgggccatcg tcgagatcga tctcgcctta tgccacaaaa acatcgctca cgcccaggaa     1800

gtagcaagcc aagcaagtag gttgttccct gaatcgaaac tgttggaggg cattgcaggg     1860

agcctaggcg tctcgccgcg accaatgcgc tctttagacg acttgttggg agggggtagt     1920

ggcttgaatc cacatcgcgc ctaccaatcg tccgtcaaca gcatgccact taaggtaaag     1980

atcatgaagc tccatgagcg ggccgtagag tgcgtcgatc aagtcaaggc tctcgttgat     2040

caaggtgaca tcatgggggc ccgcacgtac atccagtacg tgcaagacat tatcaccttt     2100

ttgcgcagta acctcgacac gtcgacggaa gcaggcaagg cggccgatgc ggcatacgcg     2160

tacttctata agatgctggt tgagtggttc ctgcagccat cgaaggtgga aagcgagtac     2220

aaggaaatgc gagatttctg gcagtcgtgg gcggacacgt gggccaaggt tgaggcatga     2280


<210>   286
<211>   2280
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 274

<400>   286
gtgaggagaa tcgtcgtgct actttcggcc tgtctcatag tgaaaaacga agctcatgtg       60

ctaccgcgtt gcttaggttc gctccaaggc gtagcagatg aaatcgtggt agtagacaca      120

ggttctacgg atgacactcc tcgcatcgcc gagtcattcg gtgcgcgtgt gtatcatttt      180

gagtggactg gagactttgc ggtagcccga aacgaatcgt tgcgatatgc gctgggcgag      240

tatgtgcttg tgatcgatgc tgatgagttt ttgccaaagg aggacggtgt tcgcctgcgt      300

caggcgctcc aagagaggcg ggccgacgct tatactgtgg acctcgtcaa ctacttagga      360

tcagtggctc gttttgtccg ttcacccggt gttcgcgtgg tgcgcgtctt tcgacgcggt      420

ttctcgtaca tgggttctat ccacgaacaa attttgtacg acgtgatcgc caaaggcggt      480

caaatcgagg ttcttgacgt cgagattcat catttaggtt atctagccga gttcgtagcg      540

cttaaaggca agtcggaccg caatctcgag atcttaaatc aggccctggc aattgatccg      600

gataattttt ttcatatcac gaaccttatg gccgaatacg cccggttagg tgatccaaaa      660

aaagtcgtgg agctgggcga gcgcgcatac gacctttttc agcgcggtcg agttaaccag      720

ccgcatctcg ttctgcgaat gtatcgcatg atgatcgcag cgcacggcga tcttggcaat      780

tatgaccgag tcgaggcact ggcgagagaa gccgagctat tctttccgaa tatcccggac      840

gtcccattcg tccatgcact ctatgtgatg caacgcggcg attggcgaaa ggcgattcgg      900

ctgtttgagc gcagtcgtga aattggtgag attcgatctg agattatcga caccatagct      960

ggcgcgggct catacgtcgc ggctgcgaag ctcggcgaac tctggctact cgagggcgat     1020

gtagaacttg ctcgagaata ttttgtacag agtttacgtg agaacctgcg tcaggagggc     1080

accttctttt tcttagcttc gcttctcccg ctgaatgatc caagcgtatt cgagcaactc     1140

cgtgccctcg cgagccacga tccagtctgt cttgcgtatc ttgccctcgc aggagcaatt     1200

tggcgggtcg accatgcttg gcggctcatc aatgaaatcg aacaaacgcc cgtgacggca     1260

ccaatcgtcg caaaactgcg cgcactcggc gcggtacttg gtattctacc cgcaaacgat     1320

gtccgagtgg attcgacggt cgaacgggaa attcaatggt acgaggcgct ctttgcactt     1380

gaacgaggag atcgcgacca ggcagagaga tgcctacgcg accaaccgga gcgttgggag     1440

cgtctgtctg agtggctaac gagcaagcaa ggtctttgca ttagcccgat cctggacgag     1500

ttgctgctag ctcgtgtcga tgagttgctt cttgcgtggc taccaagggc agaagaccga     1560

gatctcgcgc tgtcaagggt tttggcgtct ccgcttcgcg aggaagtctg gaaggctgcg     1620

tggctcggcg aacgcggctg ggagtgcgac tttttggcct tgggtgcgtt tcggcgccgc     1680

gacattcagg caagtctcaa ctggctcgag cgtggtctca cctacgagcc cacagtacgg     1740

cgggccatcg tcgagatcga tctcgcctta tgccacaaaa acatcgctca cgcccaggaa     1800

gtagcaagcc aagcaagtag gttgttccct gaatcgaaac tgttggaggg cattgcaggg     1860

agcctaggcg tctcgccgcg accaatgcgc tctttagacg acttgttggg agggggtagt     1920

ggcttgaatc cacatcgcgc ctaccaatcg tccgtcaaca gcatgccact taaggtaaag     1980

atcatgaagc tccatgagcg ggccgtagag tgcgtcgatc aagtcaaggc tctcgttgat     2040

caaggtgaca tcatgggggc ccgcacgtac atccagtacg tgcaagacat tatcaccttt     2100

ttgcgcagta acctcgacac gtcgacggaa gcaggcaagg cggccgatgc ggcatacgcg     2160

tacttctata agatgctggt tgagtggttc ctgcagccat cgaaggtgga aagcgagtac     2220

aaggaaatgc gagatttctg gcagtcgtgg gcggacacgt gggccaaggt tgaggcatga     2280


<210>   287
<211>   2280
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 274

<400>   287
gtgaggagaa tcgtcgtgct actttcggcc tgtctcatag tgaaaaacga agctcatgtg       60

ctaccgcgtt gcttaggttc gctccaaggc gtagcagatg aaatcgtggt agtagacaca      120

ggttctacgg atgacactcc tcgcatcgcc gagtcattcg gtgcgcgtgt gtatcatttt      180

gagtggactg gagactttgc ggtagcccga aacgaatcgt tgcgatatgc gctgggcgag      240

tatgtgcttg tgatcgatgc tgatgagttt ttgccaaagg aggacggtgt tcgcctgcgt      300

caggcgctcc aagagaggcg ggccgacgct tatactgtgg acctcgtcaa ctacttagga      360

tcagtggctc gttttgtccg ttcacccggt gttcgcgtgg tgcgcgtctt tcgacgcggt      420

ttctcgtaca tgggttctat ccacgaacaa attttgtacg acgtgatcgc caaaggcggt      480

caaatcgagg ttcttgacgt cgagattcat catttaggtt atctagccga gttcgtagcg      540

cttaaaggca agtcggaccg caatctcgag atcttaaatc aggccctggc aattgatccg      600

gataattttt ttcatatcac gaaccttatg gccgaatacg cccggttagg tgatccaaaa      660

aaagtcgtgg agctgggcga gcgcgcatac gacctttttc agcgcggtcg agttaaccag      720

ccgcatctcg ttctgcgaat gtatcgcatg atgatcgcag cgcacggcga tcttggcaat      780

tatgaccgag tcgaggcact ggcgagagaa gccgagctat tctttccgaa tatcccggac      840

gtcccattcg tccatgcact ctatgtgatg caacgcggcg attggcgaaa ggcgattcgg      900

ctgtttgagc gcagtcgtga aattggtgag attcgatctg agattatcga caccatagct      960

ggcgcgggct catacgtcgc ggctgcgaag ctcggcgaac tctggctact cgatggcgat     1020

gtagaacttg ctcgagaata ttttgtacag agtttacgtg agaacctgcg tcaggagggc     1080

accttctttt tcttagcttc gcttctcccg ctgaatgatc caagcgtatt cgagcaactc     1140

cgtgccctcg cgagccacga tccagtctgt cttgcgtatc ttgccctcgc aggagcagta     1200

tggcgggtcg accatgcttg gcggctcatc aatgaaatcg aacaaacgcc cgtgacggca     1260

ccaatcgtcg caaaactgcg cgcactcggc gcggtacttg gtattctacc cgcaaacgat     1320

gtccgagtgg attcgacggt cgaacgggaa attcaatggt acgaggcgct ctttgcactt     1380

gaacgaggag atcgcgacca ggcagagaga tgcctacgcg accaaccgga gcgttgggag     1440

cgtctgtctg agtggctaac gagcaagcaa ggtctttgca ttagcccgat cctggacgag     1500

ttgctgctag ctcgtgtcga tgagttgctt cttgcgtggc taccaagggc agaagaccga     1560

gatctcgcgc tgtcaagggt tttggcgtct ccgcttcgcg aggaagtctg gaaggctgcg     1620

tggctcggcg aacgcggctg ggagtgcgac tttttggcct tgggtgcgtt tcggcgccgc     1680

gacattcagg caagtctcaa ctggctcgag cgtggtctca cctacgagcc cacagtacgg     1740

cgggccatcg tcgagatcga tctcgcctta tgccacaaaa acatcgctca cgcccaggaa     1800

gtagcaagcc aagcaagtag gttgttccct gaatcgaaac tgttggaggg cattgcaggg     1860

agcctaggcg tctcgccgcg accaatgcgc tctttagacg acttgttggg agggggtagt     1920

ggcttgaatc cacatcgcgc ctaccaatcg tccgtcaaca gcatgccact taaggtaaag     1980

atcatgaagc tccatgagcg ggccgtagag tgcgtcgatc aagtcaaggc tctcgttgat     2040

caaggtgaca tcatgggggc ccgcacgtac atccagtacg tgcaagacat tatcaccttt     2100

ttgcgcagta acctcgacac gtcgacggaa gcaggcaagg cggccgatgc ggcatacgcg     2160

tacttctata agatgctggt tgagtggttc ctgcagccat cgaaggtgga aagcgagtac     2220

aaggaaatgc gagatttctg gcagtcgtgg gcggacacgt gggccaaggt tgaggcatga     2280


<210>   288
<211>   2280
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 274

<400>   288
gtgaggagaa tcgtcgtgct actttcggcc tgtctcatag tgaaaaacga agctcatgtg       60

ctaccgcgtt gcttaggttc gctccaaggc gtagcagatg aaatcgtggt agtagacaca      120

ggttctacgg atgacactcc tcgcatcgcc gagtcattcg gtgcgcgtgt gtatcatttt      180

gagtggactg gagactttgc ggtagcccga aacgaatcgt tgcgatatgc gctgggcgag      240

tatgtgcttg tgatcgatgc tgatgagttt ttgccaaagg aggacggtgt tcgcctgcgt      300

caggcgctcc aagagaggcg ggccgacgct tatactgtgg acctcgtcaa ctacttagga      360

tcagtggctc gttttgtccg ttcacccggt gttcgcgtgg tgcgcgtctt tcgacgcggt      420

ttctcgtaca tgggttctat ccacgaacaa attttgtacg acgtgatcgc caaaggcggt      480

caaatcgagg ttcttgacgt cgagattcat catttaggtt atctagccga gttcgtagcg      540

cttaaaggca agtcggaccg caatctcgag atcttaaatc aggccctggc aattgatccg      600

gataattttt ttcatatcac gaaccttatg gccgaatacg cccggttagg tgatccaaaa      660

aaagtcgtgg agctgggcga gcgcgcatac gacctttttc agcgcggtcg agttaaccag      720

ccgcatctcg ttctgcgaat gtatcgcatg atgatcgcag cgcacggcga tcttggcaat      780

tatgaccgag tcgaggcact ggcgagagaa gccgagctat tctttccgaa tatcccggac      840

gtcccattcg tccatgcact ctatgtgatg caacgcggcg attggcgaaa ggcgattcgg      900

ctgtttgagc gcagtcgtga aattggtgag attcgatctg agattatcga caccatagct      960

ggcgcgggct catacgtcgc ggctgcgaag ctcggcgaac tctggctact cgagggcgat     1020

gtagaacttg ctcgagaata ttttgtacag agtttacgtg agaacctgcg tcaggagggc     1080

accttctttt tcttagcttc gcttctcccg ctgaatgatc caagcgtatt cgagcaactc     1140

aaagccctcg cgagccacga tccagtctgt cttgcgtatc ttgccctcgc aggagcagta     1200

tggcgggtcg accatgcttg gcggctcatc aatgaaatcg aacaaacgcc cgtgacggca     1260

ccaatcgtcg caaaactgcg cgcactcggc gcggtacttg gtattctacc cgcaaacgat     1320

gtccgagtgg attcgacggt cgaacgggaa attcaatggt acgaggcgct ctttgcactt     1380

gaacgaggag atcgcgacca ggcagagaga tgcctacgcg accaaccgga gcgttgggag     1440

cgtctgtctg agtggctaac gagcaagcaa ggtctttgca ttagcccgat cctggacgag     1500

ttgctgctag ctcgtgtcga tgagttgctt cttgcgtggc taccaagggc agaagaccga     1560

gatctcgcgc tgtcaagggt tttggcgtct ccgcttcgcg aggaagtctg gaaggctgcg     1620

tggctcggcg aacgcggctg ggagtgcgac tttttggcct tgggtgcgtt tcggcgccgc     1680

gacattcagg caagtctcaa ctggctcgag cgtggtctca cctacgagcc cacagtacgg     1740

cgggccatcg tcgagatcga tctcgcctta tgccacaaaa acatcgctca cgcccaggaa     1800

gtagcaagcc aagcaagtag gttgttccct gaatcgaaac tgttggaggg cattgcaggg     1860

agcctaggcg tctcgccgcg accaatgcgc tctttagacg acttgttggg agggggtagt     1920

ggcttgaatc cacatcgcgc ctaccaatcg tccgtcaaca gcatgccact taaggtaaag     1980

atcatgaagc tccatgagcg ggccgtagag tgcgtcgatc aagtcaaggc tctcgttgat     2040

caaggtgaca tcatgggggc ccgcacgtac atccagtacg tgcaagacat tatcaccttt     2100

ttgcgcagta acctcgacac gtcgacggaa gcaggcaagg cggccgatgc ggcatacgcg     2160

tacttctata agatgctggt tgagtggttc ctgcagccat cgaaggtgga aagcgagtac     2220

aaggaaatgc gagatttctg gcagtcgtgg gcggacacgt gggccaaggt tgaggcatga     2280


<210>   289
<211>   2280
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 274

<400>   289
gtgaggagaa tcgtcgtgct actttcggcc tgtctcatag tgaaaaacga agctcatgtg       60

ctaccgcgtt gcttaggttc gctccaaggc gtagcagatg aaatcgtggt agtagacaca      120

ggttctacgg atgacactcc tcgcatcgcc gagtcattcg gtgcgcgtgt gtatcatttt      180

gagtggactg gagactttgc ggtagcccga aacgaatcgt tgcgatatgc gctgggcgag      240

tatgtgcttg tgatcgatgc tgatgagttt ttgccaaagg aggacggtgt tcgcctgcgt      300

caggcgctcc aagagaggcg ggccgacgct tatactgtgg acctcgtcaa ctacttagga      360

tcagtggctc gttttgtccg ttcacccggt gttcgcgtgg tgcgcgtctt tcgacgcggt      420

ttctcgtaca tgggttctat ccacgaacaa attttgtacg acgtgatcgc caaaggcggt      480

aatatcgagg ttcttgacgt cgagattcat catttaggtt atctagccga gttcgtagcg      540

cttaaaggca agtcggaccg caatctcgag atcttaaatc aggccctggc aattgatccg      600

gataattttt ttcatatcac gaaccttatg gccgaatacg cccggttagg tgatccaaaa      660

aaagtcgtgg agctgggcga gcgcgcatac gacctttttc agcgcggtcg agttaaccag      720

ccgcatctcg ttctgcgaat gtatcgcatg atgatcgcag cgcacggcga tcttggcaat      780

tatgaccgag tcgaggcact ggcgagagaa gccgagctat tctttccgaa tatcccggac      840

gtcccattcg tccatgcact ctatgtgatg caacgcggcg attggcgaaa ggcgattcgg      900

ctgtttgagc gcagtcgtga aattggtgag attcgatctg agattatcga caccatagct      960

ggcgcgggct catacgtcgc ggctgcgaag ctcggcgaac tctggctact cgagggcgat     1020

gtagaacttg ctcgagaata ttttgtacag agtttacgtg agaacctgcg tcaggagggc     1080

accttctttt tcttagcttc gcttctcccg ctgaatgatc caagcgtatt cgagcaactc     1140

cgtgccctcg cgagccacga tccagtctgt cttgcgtatc ttgccctcgc aggagcagta     1200

tggcgggtcg accatgcttg gcggctcatc aatgaaatcg aacaaacgcc cgtgacggca     1260

ccaatcgtcg caaaactgcg cgcactcggc gcggtacttg gtattctacc cgcaaacgat     1320

gtccgagtgg attcgacggt cgaacgggaa attcaatggt acgaggcgct ctttgcactt     1380

gaacgaggag atcgcgacca ggcagagaga tgcctacgcg accaaccgga gcgttgggag     1440

cgtctgtctg agtggctaac gagcaagcaa ggtctttgca ttagcccgat cctggacgag     1500

ttgctgctag ctcgtgtcga tgagttgctt cttgcgtggc taccaagggc agaagaccga     1560

gatctcgcgc tgtcaagggt tttggcgtct ccgcttcgcg aggaagtctg gaaggctgcg     1620

tggctcggcg aacgcggctg ggagtgcgac tttttggcct tgggtgcgtt tcggcgccgc     1680

gacattcagg caagtctcaa ctggctcgag cgtggtctca cctacgagcc cacagtacgg     1740

cgggccatcg tcgagatcga tctcgcctta tgccacaaaa acatcgctca cgcccaggaa     1800

gtagcaagcc aagcaagtag gttgttccct gaatcgaaac tgttggaggg cattgcaggg     1860

agcctaggcg tctcgccgcg accaatgcgc tctttagacg acttgttggg agggggtagt     1920

ggcttgaatc cacatcgcgc ctaccaatcg tccgtcaaca gcatgccact taaggtaaag     1980

atcatgaagc tccatgagcg ggccgtagag tgcgtcgatc aagtcaaggc tctcgttgat     2040

caaggtgaca tcatgggggc ccgcacgtac atccagtacg tgcaagacat tatcaccttt     2100

ttgcgcagta acctcgacac gtcgacggaa gcaggcaagg cggccgatgc ggcatacgcg     2160

tacttctata agatgctggt tgagtggttc ctgcagccat cgaaggtgga aagcgagtac     2220

aaggaaatgc gagatttctg gcagtcgtgg gcggacacgt gggccaaggt tgaggcatga     2280


<210>   290
<211>   383
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   290
Met Val Glu Phe Thr Leu Gln Arg Glu Asp Trp Ser Leu His Arg Lys 
                5                   10                  15      

Gly His Ile Asp Gln Glu Arg His Arg Glu Lys Val Arg Glu Ala Ile 
            20                  25                  30          

Arg Glu His Leu Ala Asp Leu Val Ser Asp Glu Ser Leu Ile Met Ser 
        35                  40                  45              

Asp Gly Lys Gln Ile Ile Lys Ile Pro Ile Arg Ser Leu Glu Glu Tyr 
    50                  55                  60                  

Arg Ile Arg Tyr Asn Phe Gln Lys Gly Lys His Val Gly Ser Gly Ser 
65                  70                  75                  80  

Gly Asp Thr Ala Val Gly Asp Leu Val Ala Arg Gly Lys Pro Asp Ala 
                85                  90                  95      

Asp Gly Gln Pro Gly Pro Gly Gln Gly Glu Gly Ala Gly Ser Glu Pro 
            100                 105                 110         

Gly Val Asp Tyr Ala Glu Ala Glu Val Thr Leu Glu Asp Ile Gln Gln 
        115                 120                 125             

Glu Leu Phe Arg Glu Leu Glu Leu Pro Asp Leu Ala Glu Lys Asp Glu 
    130                 135                 140                 

Ala Asp Met Val Val Asp Thr Val Glu Phe Arg Asp Val Arg Lys Lys 
145                 150                 155                 160 

Gly Ile Thr Ala Asn Ile Asp Lys Lys Arg Thr Leu Leu Gln Ala Leu 
                165                 170                 175     

Arg His Ala Lys Lys Asp Asp Arg Val Val Ile Thr Pro Asp Asp Leu 
            180                 185                 190         

Arg Tyr Lys Thr Trp Glu Thr Ile Val Lys Pro Asp Ser Asn Ala Val 
        195                 200                 205             

Ile Leu Ala Met Met Asp Leu Ser Gly Ser Met Gly Leu Phe Glu Lys 
    210                 215                 220                 

Tyr Cys Ala Arg Thr Phe Phe Phe Trp Met Thr Arg Phe Leu Arg Thr 
225                 230                 235                 240 

Lys Tyr Ala Asn Val Gln Ile Arg Tyr Ile Ala His His Thr Glu Ala 
                245                 250                 255     

His Glu Val Asp Glu Glu Tyr Phe Phe Thr Lys Gly Glu Ser Gly Gly 
            260                 265                 270         

Thr Ile Cys Ser Ser Ala Tyr Gln Tyr Ala Leu Asp Met Val Asn Arg 
        275                 280                 285             

Glu Tyr Pro Pro Glu Arg Tyr Asn Ile Tyr Ser Ile His Phe Ser Asp 
    290                 295                 300                 

Gly Asp Asn Leu Thr Ser Asp Asn Glu Lys Cys Val Gln Leu Val Lys 
305                 310                 315                 320 

Glu Leu Ser Ser Val Ser Arg Met Phe Gly Tyr Ala Glu Val Asn Gln 
                325                 330                 335     

Tyr Ser Arg Ser Ser Thr Leu Met Ser Ala Tyr Gly Lys Leu Gln Ile 
            340                 345                 350         

Pro Arg Phe Arg Thr Tyr Val Ile Arg Asp Lys Ser Glu Ile Tyr Gly 
        355                 360                 365             

Ala Leu Arg His Phe Phe Ser Gln Gln Gln Gly Val Lys Ser Ala 
    370                 375                 380             

<210>   291
<211>   1152
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   291
gtggtcgaat tcacacttca acgcgaagac tggtcactcc accgcaaagg gcatatcgat       60

caagagcgcc atcgcgaaaa ggtgcgcgag gccattcggg aacatctcgc cgatctcgtc      120

agcgatgaaa gcctgatcat gtcggacggg aagcagatca tcaagattcc tatccggtcg      180

cttgaggagt accgcattcg gtacaacttt cagaaaggca agcacgttgg cagcggatcc      240

ggtgacacgg ccgtgggcga tctcgtcgcc cgcggcaagc cggacgccga cggacagccc      300

ggtccgggtc agggcgaggg cgccggatcg gagccggggg tcgactacgc cgaggcggag      360

gtgacgctgg aggacatcca gcaggagctg ttccgggagc tcgaacttcc cgatctcgcc      420

gaaaaggacg aggcggacat ggtcgtggac accgtggaat ttcgcgacgt ccgcaagaag      480

ggcatcacgg ccaacatcga caagaaacgg accttgcttc aggcccttcg ccacgccaag      540

aaggacgatc gcgtcgtgat cacgccggac gatctgcgct acaagacatg ggagaccatc      600

gtcaagccag attcgaacgc ggtcatcctc gcgatgatgg atctgtcggg atcgatgggc      660

ctgttcgaga agtactgcgc aaggaccttc ttcttttgga tgacgcggtt tctgcgcacg      720

aagtacgcca acgtccagat tcggtacatc gcccatcata ccgaggcgca tgaggtcgac      780

gaggagtact ttttcacaaa gggcgagagc gggggtacca tctgttcgtc cgcgtatcag      840

tatgcgctcg acatggtgaa ccgggagtat ccgcccgagc ggtacaacat ttattccatc      900

cacttttcgg acggcgacaa cctgacgtcg gacaatgaaa aatgtgtgca gttggtgaag      960

gaactttcca gcgtttcgcg catgtttggc tacgcagagg tgaaccaata ctcgcgttcg     1020

tcgacgttga tgagtgcata cgggaagctc cagattcctc gatttcgcac gtacgtgata     1080

cgagataaat ccgagatcta cggtgcgctt cgccacttct tttcccagca gcaaggggtg     1140

aagagcgcat ga                                                         1152


<210>   292
<211>   376
<212>   PRT
<213>   Bacillus sp. B14905

<400>   292
Phe Val Ile Ser Gln Glu Asn Trp Ser Leu His Arg Lys Gly His Gln 
                5                   10                  15      

Asp Gln Gln Arg His Met Glu Lys Val Lys Asp Ala Ile Lys Asn Asn 
            20                  25                  30          

Leu Pro Asp Leu Val Ser Glu Glu Ser Ile Val Met Ser Asn Gly Arg 
        35                  40                  45              

Glu Val Ile Lys Ile Pro Ile Arg Ser Leu Asp Glu Phe Lys Ile Arg 
    50                  55                  60                  

Tyr Asn Tyr Asp Asn Ser Lys His Val Gly Gln Gly Gln Gly Asp Ser 
65                  70                  75                  80  

Asn Val Gly Asp Val Val Ala Arg Asp Gly Ser Lys Ala Asn Gln Thr 
                85                  90                  95      

Gln Gly Lys Gly Lys Glu Ala Gly Asp Lys Pro Gly Gln Asp Tyr Tyr 
            100                 105                 110         

Glu Ala Glu Val Ser Leu Glu Glu Ile Gln Asn Val Leu Phe His Glu 
        115                 120                 125             

Leu Glu Leu Pro Asn Leu Gln Gln Lys Glu Lys Ala Glu Ile Val Thr 
    130                 135                 140                 

Glu Lys Ile Glu Phe Asn Asp Ile Arg Lys Lys Gly Leu Met Gly Asn 
145                 150                 155                 160 

Val Asp Lys Lys Arg Thr Ile Leu Asn Ala Leu Lys Arg Asn Ala Met 
                165                 170                 175     

His Gly Lys Ala Glu Ile Thr Pro Ile His Asn Asp Asp Leu Arg Phe 
            180                 185                 190         

Lys Ile Trp Asp Glu Val Val Lys Pro Glu Ser Lys Ala Val Val Leu 
        195                 200                 205             

Ala Met Met Asp Thr Ser Gly Ser Met Gly Ala Phe Glu Lys Tyr Cys 
    210                 215                 220                 

Ala Arg Ser Phe Phe Phe Trp Met Thr Lys Phe Leu Arg Ser Lys Tyr 
225                 230                 235                 240 

Glu Thr Val Glu Ile Glu Phe Ile Ala His His Thr Glu Ala Lys Val 
                245                 250                 255     

Val Thr Glu Glu Glu Phe Phe Thr Lys Gly Glu Ser Gly Gly Thr Ile 
            260                 265                 270         

Cys Ser Ser Ala Tyr Lys Lys Ala Leu Glu Leu Ile Lys Glu Lys Tyr 
        275                 280                 285             

Ser Pro Ser Arg Tyr Asn Ile Tyr Pro Val His Phe Ser Asp Gly Glu 
    290                 295                 300                 

Asn Ile Ser Met Asp Asn Glu Lys Cys Leu Lys Leu Val Ala Glu Leu 
305                 310                 315                 320 

Met Asp Val Ser Ser Met Phe Gly Tyr Gly Glu Val Asn Gln His Asn 
                325                 330                 335     

Arg Phe Ser Thr Leu Met Tyr Thr Tyr Lys Lys Ile Asp Asp Pro Lys 
            340                 345                 350         

Phe Arg His His Ile Leu Arg Lys Lys Gly Asp Val Tyr Asp Ala Leu 
        355                 360                 365             

Lys Ser Phe Phe Lys Lys Asn Glu 
    370                 375     

<210>   293
<211>   376
<212>   PRT
<213>   Bacillus halodurans C-125

<400>   293
Phe Val Val Ser Gln Glu Asn Trp Thr Leu His Arg Lys Gly Tyr Gln 
                5                   10                  15      

Asp Gln Arg Arg His Gln Glu Lys Val Lys Glu Ala Ile Arg Lys Asn 
            20                  25                  30          

Leu Pro Asp Leu Val Ser Glu Glu Asn Ile Ile Met Ser Asn Gly Arg 
        35                  40                  45              

Glu Val Ile Lys Ile Pro Ile Arg Ser Leu Asp Glu Tyr Lys Ile Arg 
    50                  55                  60                  

Tyr Asn Tyr Asp Lys Asn Lys His Val Gly Gln Gly Asp Gly Asp Ser 
65                  70                  75                  80  

Gln Val Gly Asp Val Ile Ala Arg Asp Pro Ser Ala Gly Gln Gln Gly 
                85                  90                  95      

Pro Gly Lys Gly Gln Gly Ala Gly Asp Gln Pro Gly Glu Asp Tyr Phe 
            100                 105                 110         

Glu Ala Glu Val Ser Ile Leu Glu Leu Glu Glu Leu Leu Phe Arg Glu 
        115                 120                 125             

Leu Glu Leu Pro Asn Leu Gln Gln Lys Glu Glu Asp His Leu Val Val 
    130                 135                 140                 

Glu His Ile Glu Phe Asn Asp Ile Arg Lys Lys Gly Leu Met Gly Asn 
145                 150                 155                 160 

Ile Asp Lys Arg Arg Thr Ile Leu Ser Ala Ile Lys Arg Asn Ala Leu 
                165                 170                 175     

Glu Gly Arg Pro Gly Leu Ile Pro Ile Tyr Asn Asp Asp Leu Arg Phe 
            180                 185                 190         

Lys Thr Trp Asn Glu Val Val Arg Pro Glu Ser Lys Ala Val Val Leu 
        195                 200                 205             

Ala Met Met Asp Thr Ser Gly Ser Met Gly Arg Trp Glu Lys Tyr Met 
    210                 215                 220                 

Ala Arg Ser Phe Phe Phe Trp Met Thr Arg Phe Leu Arg Thr Lys Tyr 
225                 230                 235                 240 

Glu Thr Val Asp Ile Glu Phe Ile Ala His His Thr Glu Ala Lys Val 
                245                 250                 255     

Val Ser Glu Glu Asp Phe Phe Ser Lys Gly Glu Ser Gly Gly Thr Ile 
            260                 265                 270         

Cys Ser Ser Ala Tyr Arg Lys Ala Leu Glu Leu Ile Asn Glu Lys Tyr 
        275                 280                 285             

Asp Pro Ala Arg Tyr Asn Ile Tyr Pro Phe His Phe Ser Asp Gly Asp 
    290                 295                 300                 

Asn Leu Thr Ser Asp Asn Ala Arg Cys Leu Lys Leu Val His Glu Leu 
305                 310                 315                 320 

Met Glu Ser Ser Ser Met Phe Gly Tyr Gly Glu Val Asn Gln Tyr Ser 
                325                 330                 335     

Arg His Ser Thr Leu Met Asn Ala Tyr Lys Asn Leu Lys Asp Pro Arg 
            340                 345                 350         

Phe Arg Ser Tyr Val Leu Lys Glu Lys Gly Asp Val Tyr Arg Ala Met 
        355                 360                 365             

Lys Thr Phe Phe Lys Lys Glu Glu 
    370                 375     

<210>   294
<211>   377
<212>   PRT
<213>   Bacillus pumilus SAFR-032

<400>   294
Gln Phe Ile Val Ser Gln Glu Asp Trp Ser Leu His Arg Lys Gly Tyr 
                5                   10                  15      

Asp Asp Gln Gln Arg His Gln Lys Lys Val Lys Glu Ala Ile Lys Asn 
            20                  25                  30          

Asn Leu Pro Asp Leu Val Thr Glu Glu Ser Ile Ile Met Ser Asn Gly 
        35                  40                  45              

Lys Asp Val Val Lys Ile Pro Ile Arg Ser Leu Asp Glu Tyr Lys Ile 
    50                  55                  60                  

Arg Tyr Asn Tyr Asp Lys Asn Lys His Val Gly Gln Gly Asp Gly Asp 
65                  70                  75                  80  

Ser Glu Val Gly Asp Ile Val Ala Arg Asp Gly Ser Asp Ser Lys Gln 
                85                  90                  95      

Gly Gln Gly Lys Gly Gln Ser Ala Gly Asp Gln Ala Gly Glu Asp Tyr 
            100                 105                 110         

Tyr Glu Ala Glu Val Ser Leu Met Asp Leu Glu Glu Ala Leu Phe Arg 
        115                 120                 125             

Glu Leu Glu Leu Pro Asn Leu Lys Gln Lys Glu Leu Asp Asp Ile Ile 
    130                 135                 140                 

Val Glu Gln Ile Glu Phe Asn Asp Ile Arg Lys Thr Gly Leu Thr Gly 
145                 150                 155                 160 

Asn Ile His Lys Lys Arg Thr Met Leu Ser Ala Phe Lys Arg Asn Ala 
                165                 170                 175     

Met Thr Gly Ser Pro Ser Phe Tyr Pro Ile Tyr Pro Glu Asp Ile Lys 
            180                 185                 190         

Tyr Lys Thr Trp Asn Glu Val Thr Lys Pro Glu Ser Lys Ala Val Val 
        195                 200                 205             

Leu Ala Met Met Asp Thr Ser Gly Ser Met Gly Leu Trp Glu Lys Tyr 
    210                 215                 220                 

Met Ala Arg Ser Phe Phe Phe Trp Met Thr Arg Phe Leu Arg Thr Lys 
225                 230                 235                 240 

Tyr Glu Thr Val Asp Ile Glu Phe Ile Ala His His Thr Glu Ala Lys 
                245                 250                 255     

Val Val Asp Glu Glu His Phe Phe Ser Arg Gly Glu Ser Gly Gly Thr 
            260                 265                 270         

Ile Cys Ser Ser Val Tyr Arg Lys Ala Leu Glu Leu Ile Asp Glu Arg 
        275                 280                 285             

Tyr Pro Pro Ser Arg Tyr Asn Ile Tyr Pro Phe His Phe Ser Asp Gly 
    290                 295                 300                 

Asp Asn Leu Thr Ser Asp Asn Ala Arg Cys Val Lys Leu Val Ser Glu 
305                 310                 315                 320 

Ile Met Lys Lys Ala Asn Leu Phe Cys Tyr Gly Glu Val Asn Gln Tyr 
                325                 330                 335     

Asn Arg His Ser Thr Leu Met Ser Ala Tyr Lys His Ile Gln Asp Glu 
            340                 345                 350         

Lys Phe Lys His Tyr Ile Leu Lys Gln Lys Ser Asp Val Phe Leu Ala 
        355                 360                 365             

Leu Lys Lys Phe Phe Gln Gln Glu Glu 
    370                 375         

<210>   295
<211>   377
<212>   PRT
<213>   Bacillus sp. NRRL B-14911

<400>   295
Gln Phe Val Ile Ser Glu Glu Asp Trp Ser Leu His Arg Lys Gly His 
                5                   10                  15      

Asp Asp Gln Gln Arg His Gln Glu Lys Val Gln Asp Ala Ile Arg Asn 
            20                  25                  30          

Asn Leu Pro Asp Leu Ile Thr Glu Glu Ser Ile Ile Met Ser Asn Gly 
        35                  40                  45              

Arg Glu Val Val Lys Ile Pro Ile Arg Ser Leu Asp Glu Tyr Lys Ile 
    50                  55                  60                  

Arg Tyr Asn Tyr Asp Lys Asn Lys His Val Gly Gln Gly Asp Gly Asp 
65                  70                  75                  80  

Ser Gln Val Gly Asp Val Val Ala Arg Asp Gly Ser Ser Gly Gln Lys 
                85                  90                  95      

Gly Pro Gly Lys Gly Gln Gly Ala Gly Asp Gln Pro Gly Glu Asp Tyr 
            100                 105                 110         

Phe Glu Ala Glu Val Ser Met Met Glu Leu Glu Glu Ala Leu Phe Lys 
        115                 120                 125             

Gln Leu Glu Leu Pro Asn Leu Lys Arg Lys Glu Gln Glu Glu His Leu 
    130                 135                 140                 

Val Glu Asn Ile Glu Phe Asn Asp Ile Arg Lys Thr Gly Leu Met Gly 
145                 150                 155                 160 

Asn Ile Asp Lys Lys Arg Thr Met Met Thr Ala Phe Lys Arg Asn Ala 
                165                 170                 175     

Met Thr Gly Lys Pro Ala Phe Tyr Pro Ile Tyr Gln Glu Asp Leu Lys 
            180                 185                 190         

Phe Lys Thr Trp Asn Glu Ile Val Lys Pro Asp Ser Lys Ala Val Val 
        195                 200                 205             

Leu Ala Met Met Asp Thr Ser Gly Ser Met Gly Leu Trp Glu Lys Tyr 
    210                 215                 220                 

Met Ala Arg Ser Phe Phe Phe Trp Met Thr Arg Phe Leu Arg Thr Lys 
225                 230                 235                 240 

Tyr Glu Thr Val Glu Ile Glu Phe Ile Ala His His Thr Glu Ala Lys 
                245                 250                 255     

Val Val Ser Glu Glu Asp Phe Phe Ser Lys Gly Glu Ser Gly Gly Thr 
            260                 265                 270         

Ile Cys Ser Ser Ala Tyr Arg Lys Ala Leu Glu Leu Ile Asn Glu Lys 
        275                 280                 285             

Tyr Asn Pro Arg Arg Phe Asn Ile Tyr Pro Phe His Phe Ser Asp Gly 
    290                 295                 300                 

Asp Asn Leu Thr Ser Asp Asn Ala Arg Cys Val Lys Leu Val Glu Glu 
305                 310                 315                 320 

Leu Ile Ala Val Ser Ser Met Phe Gly Tyr Gly Glu Val Asn Gln Tyr 
                325                 330                 335     

Asn Arg His Ser Thr Leu Met Ser Ala Tyr Lys Asn Ile Lys Asn Glu 
            340                 345                 350         

His Phe Arg Tyr Tyr Ile Leu Lys Gln Lys Ala Asp Val Phe His Ala 
        355                 360                 365             

Met Lys Ser Phe Phe Gln Asn Glu Glu 
    370                 375         

<210>   296
<211>   374
<212>   PRT
<213>   Paenibacillus larvae subsp. larvae BRL-230010

<400>   296
Phe Ile Val Ser Arg Glu Asn Trp Ser Leu His Arg Lys Gly Tyr Gln 
                5                   10                  15      

Asp Gln Thr Arg His Gln Gln Lys Ile Lys Asp Ala Ile Lys Gln Asn 
            20                  25                  30          

Leu Pro Asp Leu Val Thr Glu Glu Asn Ile Ile Leu Ser Asn Gly Lys 
        35                  40                  45              

Gln Ile Ile Lys Ile Pro Ile Arg Ser Leu Asp Glu Tyr Arg Phe Arg 
    50                  55                  60                  

Phe Asn Tyr Asn Lys Ser Lys His Val Gly Gln Gly Asp Gly Asp Ser 
65                  70                  75                  80  

Gln Val Gly Asp Val Leu Gly Ile Asp Pro Tyr Thr Gln Gln Gly Lys 
                85                  90                  95      

Gly Ala Gly Ala Gly Asp Gln Ala Gly Glu Asp Tyr Tyr Glu Ala Glu 
            100                 105                 110         

Val Asp Met Glu Glu Leu Gln Ser Leu Leu Phe Glu Glu Leu Glu Leu 
        115                 120                 125             

Pro Tyr Leu Asn Pro Lys Glu Arg Leu Asp Ile Ser Thr Gln Asp Ile 
    130                 135                 140                 

Ile Phe Asn Asp Ile Arg Lys Lys Gly Ile Met Ser Asn Ile Asp Lys 
145                 150                 155                 160 

Lys Arg Thr Ile Leu Glu Asn Ile Arg Arg Asn Ala Ser Ser Gly Thr 
                165                 170                 175     

Pro Gly Ile His Gly Ile Ser Pro Asp Asp Leu Arg Phe Lys Thr Trp 
            180                 185                 190         

Asp Glu Ile Glu Lys Pro His Ser Asn Ala Leu Ile Leu Ala Met Met 
        195                 200                 205             

Asp Thr Ser Gly Ser Met Gly Ser Phe Glu Lys Tyr Ile Ala Arg Ser 
    210                 215                 220                 

Phe Phe Phe Trp Met Thr Arg Phe Leu Arg Ser Lys Tyr Glu His Val 
225                 230                 235                 240 

Asp Ile Val Phe Ile Ala His His Thr Glu Ala Arg Ile Val Ser Glu 
                245                 250                 255     

Glu Glu Phe Phe Thr Lys Gly Glu Ser Gly Gly Thr Ile Cys Ser Ser 
            260                 265                 270         

Ala Tyr Gln Ala Ala Leu Asp Val Ile Asp Arg Ser Tyr Pro Pro Ser 
        275                 280                 285             

Lys Tyr Asn Ile Tyr Pro Phe His Phe Ser Asp Gly Asp Asn Leu Thr 
    290                 295                 300                 

Ser Asp Asn Glu Arg Cys Val Lys Leu Ile Gln Arg Leu Met Glu Arg 
305                 310                 315                 320 

Ser Asn Met Phe Gly Tyr Gly Glu Val Asn Gln Tyr Asn Arg Ser Ser 
                325                 330                 335     

Thr Leu Met Gln Thr Tyr Arg His Ile Gln Asp Pro Lys Phe Leu Tyr 
            340                 345                 350         

Tyr Ile Ile Arg Glu Lys Gly Glu Val Tyr Lys Ala Leu Lys Thr Phe 
        355                 360                 365             

Phe Ala Lys Pro Glu Gly 
    370                 

<210>   297
<211>   383
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 290

<400>   297
Met Val Glu Phe Thr Leu Gln Arg Glu Asp Trp Ser Leu His Arg Lys 
                5                   10                  15      

Gly His Ile Asp Gln Glu Arg His Arg Glu Lys Val Arg Glu Ala Ile 
            20                  25                  30          

Arg Glu His Leu Ala Asp Leu Val Ser Asp Glu Ser Leu Ile Met Ser 
        35                  40                  45              

Asp Gly Lys Gln Ile Ile Lys Ile Pro Ile Arg Ser Leu Glu Glu Tyr 
    50                  55                  60                  

Arg Ile Arg Tyr Asn Phe Gln Lys Gly Lys His Val Gly Ser Gly Ser 
65                  70                  75                  80  

Gly Asp Thr Ala Val Gly Asp Leu Val Ala Arg Gly Lys Pro Asp Ala 
                85                  90                  95      

Asp Gly Gln Pro Gly Pro Gly Gln Gly Glu Gly Ala Gly Ser Glu Pro 
            100                 105                 110         

Gly Val Asp Tyr Ala Glu Ala Glu Val Thr Leu Glu Asp Ile Gln Gln 
        115                 120                 125             

Glu Leu Phe Arg Glu Leu Glu Leu Pro Asp Leu Ala Glu Lys Asp Glu 
    130                 135                 140                 

Ala Asp Met Val Val Asp Thr Val Glu Phe Arg Asp Val Arg Lys Lys 
145                 150                 155                 160 

Gly Ile Thr Ala Asn Ile Asp Lys Lys Arg Thr Leu Leu Gln Ala Leu 
                165                 170                 175     

Arg His Ala Lys Lys Asp Asp Arg Val Val Ile Thr Pro Asp Asp Leu 
            180                 185                 190         

Arg Tyr Lys Thr Trp Glu Thr Ile Val Lys Pro Asp Ser Asn Ala Val 
        195                 200                 205             

Ile Leu Ala Met Met Asp Leu Ser Gly Ser Met Gly Leu Phe Glu Lys 
    210                 215                 220                 

Tyr Cys Ala Arg Thr Phe Phe Phe Trp Met Thr Arg Phe Leu Arg Thr 
225                 230                 235                 240 

Lys Tyr Ala Asn Val Gln Ile Arg Tyr Ile Ala His His Thr Glu Ala 
                245                 250                 255     

His Glu Val Asp Glu Glu Tyr Phe Phe Thr Lys Gly Glu Ser Gly Gly 
            260                 265                 270         

Thr Ile Cys Ser Ser Ala Tyr Gln Tyr Ala Leu Asp Met Val Asn Arg 
        275                 280                 285             

Glu Tyr Pro Pro Glu Arg Tyr Asn Ile Tyr Ser Ile His Phe Ser Asp 
    290                 295                 300                 

Gly Asp Asn Leu Thr Ser Asp Asn Glu Lys Cys Val Gln Leu Val Lys 
305                 310                 315                 320 

Glu Leu Ser Ser Val Ser Arg Met Phe Gly Tyr Ala Glu Val Asn Gln 
                325                 330                 335     

Tyr Ser Arg Ser Ser Thr Leu Met Ser Ala Tyr Gly Lys Leu Gln Ile 
            340                 345                 350         

Pro Arg Phe Lys Thr Tyr Val Ile Arg Asp Lys Ser Glu Ile Tyr Gly 
        355                 360                 365             

Ala Leu Arg His Phe Phe Ser Gln Gln Gln Gly Val Lys Ser Ala 
    370                 375                 380             

<210>   298
<211>   383
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 290

<400>   298
Met Val Glu Phe Thr Leu Gln Arg Glu Asp Trp Ser Leu His Arg Lys 
                5                   10                  15      

Gly His Ile Asp Gln Glu Arg His Arg Glu Lys Val Arg Glu Ala Ile 
            20                  25                  30          

Arg Glu His Leu Ala Asp Leu Val Ser Asp Glu Ser Leu Ile Met Ser 
        35                  40                  45              

Asp Gly Lys Gln Ile Ile Lys Ile Pro Ile Arg Ser Leu Glu Glu Tyr 
    50                  55                  60                  

Arg Ile Arg Tyr Asn Phe Gln Lys Gly Lys His Val Gly Ser Gly Ser 
65                  70                  75                  80  

Gly Asp Thr Ala Val Gly Asp Leu Val Ala Arg Gly Lys Pro Glu Ala 
                85                  90                  95      

Asp Gly Gln Pro Gly Pro Gly Gln Gly Glu Gly Ala Gly Ser Glu Pro 
            100                 105                 110         

Gly Val Asp Tyr Ala Glu Ala Glu Val Thr Leu Glu Asp Ile Gln Gln 
        115                 120                 125             

Glu Leu Phe Arg Glu Leu Glu Leu Pro Asp Leu Ala Glu Lys Asp Glu 
    130                 135                 140                 

Ala Asp Met Val Val Asp Thr Val Glu Phe Arg Asp Val Arg Lys Lys 
145                 150                 155                 160 

Gly Ile Thr Ala Asn Ile Asp Lys Lys Arg Thr Leu Leu Gln Ala Leu 
                165                 170                 175     

Arg His Ala Lys Lys Asp Asp Arg Val Val Ile Thr Pro Asp Asp Leu 
            180                 185                 190         

Arg Tyr Lys Thr Trp Glu Thr Ile Val Lys Pro Asp Ser Asn Ala Val 
        195                 200                 205             

Ile Leu Ala Met Met Asp Leu Ser Gly Ser Met Gly Leu Phe Glu Lys 
    210                 215                 220                 

Tyr Cys Ala Arg Thr Phe Phe Phe Trp Met Thr Arg Phe Leu Arg Thr 
225                 230                 235                 240 

Lys Tyr Ala Asn Val Gln Ile Arg Tyr Ile Ala His His Thr Glu Ala 
                245                 250                 255     

His Glu Val Asp Glu Glu Tyr Phe Phe Thr Lys Gly Glu Ser Gly Gly 
            260                 265                 270         

Thr Ile Cys Ser Ser Ala Tyr Gln Tyr Ala Leu Asp Met Val Asn Arg 
        275                 280                 285             

Glu Tyr Pro Pro Glu Arg Tyr Asn Ile Tyr Ser Ile His Phe Ser Asp 
    290                 295                 300                 

Gly Asp Asn Leu Thr Ser Asp Asn Glu Lys Cys Val Gln Leu Val Lys 
305                 310                 315                 320 

Glu Leu Ser Ser Val Ser Arg Met Phe Gly Tyr Ala Glu Val Asn Gln 
                325                 330                 335     

Tyr Ser Arg Ser Ser Thr Leu Met Ser Ala Tyr Gly Lys Leu Gln Ile 
            340                 345                 350         

Pro Arg Phe Arg Thr Tyr Val Ile Arg Asp Lys Ser Glu Ile Tyr Gly 
        355                 360                 365             

Ala Leu Arg His Phe Phe Ser Gln Gln Gln Gly Val Lys Ser Ala 
    370                 375                 380             

<210>   299
<211>   383
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 290

<400>   299
Met Val Glu Phe Thr Leu Gln Arg Glu Asp Trp Ser Leu His Arg Lys 
                5                   10                  15      

Gly His Ile Asp Gln Glu Arg His Arg Glu Lys Val Arg Glu Ala Ile 
            20                  25                  30          

Arg Glu His Leu Ala Asp Leu Val Ser Asp Glu Ser Leu Ile Met Ser 
        35                  40                  45              

Asp Gly Lys Gln Ile Ile Lys Ile Pro Ile Arg Ser Leu Glu Glu Tyr 
    50                  55                  60                  

Arg Ile Arg Tyr Asn Phe Gln Lys Gly Lys His Val Gly Ser Gly Ser 
65                  70                  75                  80  

Gly Asp Thr Ala Val Gly Asp Leu Val Ala Arg Gly Lys Pro Asp Ala 
                85                  90                  95      

Asp Gly Gln Pro Gly Pro Gly Gln Gly Glu Gly Ala Gly Ser Glu Pro 
            100                 105                 110         

Gly Val Asp Tyr Ala Glu Ala Glu Val Thr Leu Glu Asp Ile Gln Gln 
        115                 120                 125             

Glu Leu Phe Arg Glu Leu Glu Leu Pro Asp Leu Ala Glu Lys Asp Glu 
    130                 135                 140                 

Ala Asp Met Val Val Asp Thr Val Glu Phe Arg Asp Val Arg Lys Lys 
145                 150                 155                 160 

Gly Ile Thr Ala Asn Ile Asp Lys Lys Arg Thr Leu Leu Gln Ala Leu 
                165                 170                 175     

Arg His Ala Lys Lys Asp Asp Arg Val Val Ile Thr Pro Asp Asp Leu 
            180                 185                 190         

Arg Tyr Lys Thr Trp Glu Thr Ile Val Lys Pro Asp Ser Asn Ala Val 
        195                 200                 205             

Ile Leu Ala Met Met Asp Leu Ser Gly Ser Met Gly Leu Phe Glu Lys 
    210                 215                 220                 

Tyr Cys Ala Arg Thr Phe Phe Phe Trp Met Thr Arg Phe Leu Arg Thr 
225                 230                 235                 240 

Lys Tyr Ala Asn Val Gln Ile Lys Tyr Ile Ala His His Thr Glu Ala 
                245                 250                 255     

His Glu Val Asp Glu Glu Tyr Phe Phe Thr Lys Gly Glu Ser Gly Gly 
            260                 265                 270         

Thr Ile Cys Ser Ser Ala Tyr Gln Tyr Ala Leu Asp Met Val Asn Arg 
        275                 280                 285             

Glu Tyr Pro Pro Glu Arg Tyr Asn Ile Tyr Ser Ile His Phe Ser Asp 
    290                 295                 300                 

Gly Asp Asn Leu Thr Ser Asp Asn Glu Lys Cys Val Gln Leu Val Lys 
305                 310                 315                 320 

Glu Leu Ser Ser Val Ser Arg Met Phe Gly Tyr Ala Glu Val Asn Gln 
                325                 330                 335     

Tyr Ser Arg Ser Ser Thr Leu Met Ser Ala Tyr Gly Lys Leu Gln Ile 
            340                 345                 350         

Pro Arg Phe Arg Thr Tyr Val Ile Arg Asp Lys Ser Glu Ile Tyr Gly 
        355                 360                 365             

Ala Leu Arg His Phe Phe Ser Gln Gln Gln Gly Val Lys Ser Ala 
    370                 375                 380             

<210>   300
<211>   383
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 290

<400>   300
Met Val Glu Phe Thr Leu Gln Arg Glu Asp Trp Ser Leu His Arg Lys 
                5                   10                  15      

Gly His Ile Asp Gln Glu Arg His Arg Glu Lys Val Arg Glu Ala Ile 
            20                  25                  30          

Arg Glu His Leu Ala Asp Leu Val Ser Asp Glu Ser Leu Ile Met Ser 
        35                  40                  45              

Asp Gly Lys Gln Ile Ile Lys Ile Pro Ile Arg Ser Leu Glu Glu Tyr 
    50                  55                  60                  

Arg Ile Arg Tyr Asn Phe Gln Lys Gly Lys His Val Gly Ser Gly Ser 
65                  70                  75                  80  

Gly Asp Thr Ala Val Gly Asp Leu Val Ala Arg Gly Lys Pro Asp Ala 
                85                  90                  95      

Asp Gly Gln Pro Gly Pro Gly Gln Gly Glu Gly Ala Gly Ser Glu Pro 
            100                 105                 110         

Gly Val Asp Tyr Ala Glu Ala Glu Val Thr Leu Glu Asp Ile Gln Gln 
        115                 120                 125             

Glu Leu Phe Arg Glu Leu Glu Leu Pro Asp Leu Ala Glu Lys Asp Glu 
    130                 135                 140                 

Ala Asp Met Val Val Asp Thr Val Glu Phe Arg Asp Val Arg Lys Lys 
145                 150                 155                 160 

Gly Ile Thr Ala Asn Ile Asp Lys Lys Arg Thr Leu Leu Gln Ala Leu 
                165                 170                 175     

Arg His Ala Lys Lys Asp Asp Arg Val Val Ile Thr Pro Asp Asp Leu 
            180                 185                 190         

Arg Tyr Lys Thr Trp Glu Thr Ile Val Lys Pro Asp Ser Asn Ala Val 
        195                 200                 205             

Ile Leu Ala Met Met Asp Leu Ser Gly Ser Met Gly Leu Phe Glu Lys 
    210                 215                 220                 

Tyr Cys Ala Arg Thr Phe Phe Phe Trp Met Thr Arg Phe Leu Arg Thr 
225                 230                 235                 240 

Lys Tyr Ala Asn Val Gln Ile Arg Tyr Ile Ala His His Thr Glu Ala 
                245                 250                 255     

His Glu Val Asp Glu Glu Tyr Phe Phe Thr Lys Gly Glu Ser Gly Gly 
            260                 265                 270         

Thr Ile Cys Ser Ser Ala Tyr Gln Tyr Ala Leu Asp Met Val Asn Arg 
        275                 280                 285             

Glu Tyr Pro Pro Glu Arg Tyr Asn Ile Tyr Ser Ile His Phe Ser Asp 
    290                 295                 300                 

Gly Asp Asn Leu Thr Ser Asp Asn Glu Lys Cys Val Gln Leu Val Lys 
305                 310                 315                 320 

Glu Leu Ser Ser Val Ser Arg Met Phe Gly Tyr Ala Glu Val Asn Gln 
                325                 330                 335     

Tyr Ser Arg Ser Ser Thr Leu Met Ser Ala Tyr Gly Lys Leu Gln Ile 
            340                 345                 350         

Pro Arg Phe Arg Thr Tyr Val Ile Arg Asp Lys Ser Glu Ile Tyr Gly 
        355                 360                 365             

Ala Leu Arg His Phe Phe Ser Gln Gln Gln Gly Val Arg Ser Ala 
    370                 375                 380             

<210>   301
<211>   383
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 290

<400>   301
Met Val Glu Phe Thr Leu Gln Arg Glu Asp Trp Ser Leu His Arg Lys 
                5                   10                  15      

Gly His Ile Asp Gln Glu Arg His Arg Glu Lys Val Arg Glu Ala Ile 
            20                  25                  30          

Arg Glu His Leu Ala Asp Leu Val Ser Asp Glu Ser Leu Ile Met Ser 
        35                  40                  45              

Asp Gly Lys Gln Ile Ile Lys Ile Pro Ile Arg Ser Leu Glu Glu Tyr 
    50                  55                  60                  

Arg Ile Arg Tyr Asn Phe Gln Lys Gly Lys His Val Gly Ser Gly Ser 
65                  70                  75                  80  

Gly Asp Thr Ala Val Gly Asp Leu Val Ala Arg Gly Lys Pro Asp Ala 
                85                  90                  95      

Asp Gly Gln Pro Gly Pro Gly Gln Gly Glu Gly Ala Gly Ser Glu Pro 
            100                 105                 110         

Gly Val Asp Tyr Ala Glu Ala Glu Val Thr Leu Glu Asp Ile Gln Gln 
        115                 120                 125             

Glu Leu Phe Arg Glu Leu Glu Leu Pro Asp Leu Ala Glu Lys Asp Glu 
    130                 135                 140                 

Ala Asp Met Val Val Asp Thr Val Glu Phe Arg Asp Val Arg Lys Lys 
145                 150                 155                 160 

Gly Ile Thr Ala Asn Ile Asp Lys Lys Arg Thr Leu Leu Gln Ala Leu 
                165                 170                 175     

Arg His Ala Lys Lys Asp Asp Arg Val Val Ile Thr Pro Asp Asp Leu 
            180                 185                 190         

Arg Tyr Lys Thr Trp Glu Thr Ile Val Lys Pro Asp Ser Asn Ala Val 
        195                 200                 205             

Ile Leu Ala Met Met Asp Leu Ser Gly Ser Met Gly Leu Phe Glu Lys 
    210                 215                 220                 

Tyr Cys Ala Arg Thr Phe Phe Phe Trp Met Thr Arg Phe Leu Arg Thr 
225                 230                 235                 240 

Lys Tyr Ala Gln Val Gln Ile Arg Tyr Ile Ala His His Thr Glu Ala 
                245                 250                 255     

His Glu Val Asp Glu Glu Tyr Phe Phe Thr Lys Gly Glu Ser Gly Gly 
            260                 265                 270         

Thr Ile Cys Ser Ser Ala Tyr Gln Tyr Ala Leu Asp Met Val Asn Arg 
        275                 280                 285             

Glu Tyr Pro Pro Glu Arg Tyr Asn Ile Tyr Ser Ile His Phe Ser Asp 
    290                 295                 300                 

Gly Asp Asn Leu Thr Ser Asp Asn Glu Lys Cys Val Gln Leu Val Lys 
305                 310                 315                 320 

Glu Leu Ser Ser Val Ser Arg Met Phe Gly Tyr Ala Glu Val Asn Gln 
                325                 330                 335     

Tyr Ser Arg Ser Ser Thr Leu Met Ser Ala Tyr Gly Lys Leu Gln Ile 
            340                 345                 350         

Pro Arg Phe Arg Thr Tyr Val Ile Arg Asp Lys Ser Glu Ile Tyr Gly 
        355                 360                 365             

Ala Leu Arg His Phe Phe Ser Gln Gln Gln Gly Val Lys Ser Ala 
    370                 375                 380             

<210>   302
<211>   1152
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 291

<400>   302
gtggtcgaat tcacacttca acgcgaagac tggtcactcc accgcaaagg gcatatcgat       60

caagagcgcc atcgcgaaaa ggtgcgcgag gccattcggg aacatctcgc cgatctcgtc      120

agcgatgaaa gcctgatcat gtcggacggg aagcagatca tcaagattcc tatccggtcg      180

cttgaggagt accgcattcg gtacaacttt cagaaaggca agcacgttgg cagcggatcc      240

ggtgacacgg ccgtgggcga tctcgtcgcc cgcggcaagc cggacgccga cggacagccc      300

ggtccgggtc agggcgaggg cgccggatcg gagccggggg tcgactacgc cgaggcggag      360

gtgacgctgg aggacatcca gcaggagctg ttccgggagc tcgaacttcc cgatctcgcc      420

gaaaaggacg aggcggacat ggtcgtggac accgtggaat ttcgcgacgt ccgcaagaag      480

ggcatcacgg ccaacatcga caagaaacgg accttgcttc aggcccttcg ccacgccaag      540

aaggacgatc gcgtcgtgat cacgccggac gatctgcgct acaagacatg ggagaccatc      600

gtcaagccag attcgaacgc ggtcatcctc gcgatgatgg atctgtcggg atcgatgggc      660

ctgttcgaga agtactgcgc aaggaccttc ttcttttgga tgacgcggtt tctgcgcacg      720

aagtacgcca acgtccagat tcggtacatc gcccatcata ccgaggcgca tgaggtcgac      780

gaggagtact ttttcacaaa gggcgagagc gggggtacca tctgttcgtc cgcgtatcag      840

tatgcgctcg acatggtgaa ccgggagtat ccgcccgagc ggtacaacat ttattccatc      900

cacttttcgg acggcgacaa cctgacgtcg gacaatgaaa aatgtgtgca gttggtgaag      960

gaactttcca gcgtttcgcg catgtttggc tacgcagagg tgaaccaata ctcgcgttcg     1020

tcgacgttga tgagtgcata cgggaagctc cagattcctc gatttaaaac gtacgtgata     1080

cgagataaat ccgagatcta cggtgcgctt cgccacttct tttcccagca gcaaggggtg     1140

aagagcgcat ga                                                         1152


<210>   303
<211>   1152
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 291

<400>   303
gtggtcgaat tcacacttca acgcgaagac tggtcactcc accgcaaagg gcatatcgat       60

caagagcgcc atcgcgaaaa ggtgcgcgag gccattcggg aacatctcgc cgatctcgtc      120

agcgatgaaa gcctgatcat gtcggacggg aagcagatca tcaagattcc tatccggtcg      180

cttgaggagt accgcattcg gtacaacttt cagaaaggca agcacgttgg cagcggatcc      240

ggtgacacgg ccgtgggcga tctcgtcgcc cgcggcaagc cggaagccga cggacagccc      300

ggtccgggtc agggcgaggg cgccggatcg gagccggggg tcgactacgc cgaggcggag      360

gtgacgctgg aggacatcca gcaggagctg ttccgggagc tcgaacttcc cgatctcgcc      420

gaaaaggacg aggcggacat ggtcgtggac accgtggaat ttcgcgacgt ccgcaagaag      480

ggcatcacgg ccaacatcga caagaaacgg accttgcttc aggcccttcg ccacgccaag      540

aaggacgatc gcgtcgtgat cacgccggac gatctgcgct acaagacatg ggagaccatc      600

gtcaagccag attcgaacgc ggtcatcctc gcgatgatgg atctgtcggg atcgatgggc      660

ctgttcgaga agtactgcgc aaggaccttc ttcttttgga tgacgcggtt tctgcgcacg      720

aagtacgcca acgtccagat tcggtacatc gcccatcata ccgaggcgca tgaggtcgac      780

gaggagtact ttttcacaaa gggcgagagc gggggtacca tctgttcgtc cgcgtatcag      840

tatgcgctcg acatggtgaa ccgggagtat ccgcccgagc ggtacaacat ttattccatc      900

cacttttcgg acggcgacaa cctgacgtcg gacaatgaaa aatgtgtgca gttggtgaag      960

gaactttcca gcgtttcgcg catgtttggc tacgcagagg tgaaccaata ctcgcgttcg     1020

tcgacgttga tgagtgcata cgggaagctc cagattcctc gatttcgcac gtacgtgata     1080

cgagataaat ccgagatcta cggtgcgctt cgccacttct tttcccagca gcaaggggtg     1140

aagagcgcat ga                                                         1152


<210>   304
<211>   1152
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 291

<400>   304
gtggtcgaat tcacacttca acgcgaagac tggtcactcc accgcaaagg gcatatcgat       60

caagagcgcc atcgcgaaaa ggtgcgcgag gccattcggg aacatctcgc cgatctcgtc      120

agcgatgaaa gcctgatcat gtcggacggg aagcagatca tcaagattcc tatccggtcg      180

cttgaggagt accgcattcg gtacaacttt cagaaaggca agcacgttgg cagcggatcc      240

ggtgacacgg ccgtgggcga tctcgtcgcc cgcggcaagc cggacgccga cggacagccc      300

ggtccgggtc agggcgaggg cgccggatcg gagccggggg tcgactacgc cgaggcggag      360

gtgacgctgg aggacatcca gcaggagctg ttccgggagc tcgaacttcc cgatctcgcc      420

gaaaaggacg aggcggacat ggtcgtggac accgtggaat ttcgcgacgt ccgcaagaag      480

ggcatcacgg ccaacatcga caagaaacgg accttgcttc aggcccttcg ccacgccaag      540

aaggacgatc gcgtcgtgat cacgccggac gatctgcgct acaagacatg ggagaccatc      600

gtcaagccag attcgaacgc ggtcatcctc gcgatgatgg atctgtcggg atcgatgggc      660

ctgttcgaga agtactgcgc aaggaccttc ttcttttgga tgacgcggtt tctgcgcacg      720

aagtacgcca acgtccagat taaatacatc gcccatcata ccgaggcgca tgaggtcgac      780

gaggagtact ttttcacaaa gggcgagagc gggggtacca tctgttcgtc cgcgtatcag      840

tatgcgctcg acatggtgaa ccgggagtat ccgcccgagc ggtacaacat ttattccatc      900

cacttttcgg acggcgacaa cctgacgtcg gacaatgaaa aatgtgtgca gttggtgaag      960

gaactttcca gcgtttcgcg catgtttggc tacgcagagg tgaaccaata ctcgcgttcg     1020

tcgacgttga tgagtgcata cgggaagctc cagattcctc gatttcgcac gtacgtgata     1080

cgagataaat ccgagatcta cggtgcgctt cgccacttct tttcccagca gcaaggggtg     1140

aagagcgcat ga                                                         1152


<210>   305
<211>   1152
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 291

<400>   305
gtggtcgaat tcacacttca acgcgaagac tggtcactcc accgcaaagg gcatatcgat       60

caagagcgcc atcgcgaaaa ggtgcgcgag gccattcggg aacatctcgc cgatctcgtc      120

agcgatgaaa gcctgatcat gtcggacggg aagcagatca tcaagattcc tatccggtcg      180

cttgaggagt accgcattcg gtacaacttt cagaaaggca agcacgttgg cagcggatcc      240

ggtgacacgg ccgtgggcga tctcgtcgcc cgcggcaagc cggacgccga cggacagccc      300

ggtccgggtc agggcgaggg cgccggatcg gagccggggg tcgactacgc cgaggcggag      360

gtgacgctgg aggacatcca gcaggagctg ttccgggagc tcgaacttcc cgatctcgcc      420

gaaaaggacg aggcggacat ggtcgtggac accgtggaat ttcgcgacgt ccgcaagaag      480

ggcatcacgg ccaacatcga caagaaacgg accttgcttc aggcccttcg ccacgccaag      540

aaggacgatc gcgtcgtgat cacgccggac gatctgcgct acaagacatg ggagaccatc      600

gtcaagccag attcgaacgc ggtcatcctc gcgatgatgg atctgtcggg atcgatgggc      660

ctgttcgaga agtactgcgc aaggaccttc ttcttttgga tgacgcggtt tctgcgcacg      720

aagtacgcca acgtccagat tcggtacatc gcccatcata ccgaggcgca tgaggtcgac      780

gaggagtact ttttcacaaa gggcgagagc gggggtacca tctgttcgtc cgcgtatcag      840

tatgcgctcg acatggtgaa ccgggagtat ccgcccgagc ggtacaacat ttattccatc      900

cacttttcgg acggcgacaa cctgacgtcg gacaatgaaa aatgtgtgca gttggtgaag      960

gaactttcca gcgtttcgcg catgtttggc tacgcagagg tgaaccaata ctcgcgttcg     1020

tcgacgttga tgagtgcata cgggaagctc cagattcctc gatttcgcac gtacgtgata     1080

cgagataaat ccgagatcta cggtgcgctt cgccacttct tttcccagca gcaaggggtg     1140

cgtagcgcat ga                                                         1152


<210>   306
<211>   1152
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 291

<400>   306
gtggtcgaat tcacacttca acgcgaagac tggtcactcc accgcaaagg gcatatcgat       60

caagagcgcc atcgcgaaaa ggtgcgcgag gccattcggg aacatctcgc cgatctcgtc      120

agcgatgaaa gcctgatcat gtcggacggg aagcagatca tcaagattcc tatccggtcg      180

cttgaggagt accgcattcg gtacaacttt cagaaaggca agcacgttgg cagcggatcc      240

ggtgacacgg ccgtgggcga tctcgtcgcc cgcggcaagc cggacgccga cggacagccc      300

ggtccgggtc agggcgaggg cgccggatcg gagccggggg tcgactacgc cgaggcggag      360

gtgacgctgg aggacatcca gcaggagctg ttccgggagc tcgaacttcc cgatctcgcc      420

gaaaaggacg aggcggacat ggtcgtggac accgtggaat ttcgcgacgt ccgcaagaag      480

ggcatcacgg ccaacatcga caagaaacgg accttgcttc aggcccttcg ccacgccaag      540

aaggacgatc gcgtcgtgat cacgccggac gatctgcgct acaagacatg ggagaccatc      600

gtcaagccag attcgaacgc ggtcatcctc gcgatgatgg atctgtcggg atcgatgggc      660

ctgttcgaga agtactgcgc aaggaccttc ttcttttgga tgacgcggtt tctgcgcacg      720

aagtacgccc aagtccagat tcggtacatc gcccatcata ccgaggcgca tgaggtcgac      780

gaggagtact ttttcacaaa gggcgagagc gggggtacca tctgttcgtc cgcgtatcag      840

tatgcgctcg acatggtgaa ccgggagtat ccgcccgagc ggtacaacat ttattccatc      900

cacttttcgg acggcgacaa cctgacgtcg gacaatgaaa aatgtgtgca gttggtgaag      960

gaactttcca gcgtttcgcg catgtttggc tacgcagagg tgaaccaata ctcgcgttcg     1020

tcgacgttga tgagtgcata cgggaagctc cagattcctc gatttcgcac gtacgtgata     1080

cgagataaat ccgagatcta cggtgcgctt cgccacttct tttcccagca gcaaggggtg     1140

aagagcgcat ga                                                         1152


<210>  307
<211>  959
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<400>  307

Met Lys Arg Pro Trp Ser Ala Ala Leu Ala Ala Leu Ile Ala Leu Gly 
1               5                   10                  15      


Thr Gly Ala Ser Pro Ala Trp Ala Ala Ala His Pro Ser Pro Lys Val 
            20                  25                  30          


Pro Ala Gly Ala Ala Gly Arg Val Arg Ala Ala Asp Val Val Ser Thr 
        35                  40                  45              


Pro Ile Ser Met Glu Ile Gln Val Ile His Asp Ala Leu Thr Val Pro 
    50                  55                  60                  


Glu Leu Ala Ala Val Gln Ala Ala Ala Gln Ala Ala Ser Asn Leu Ser 
65                  70                  75                  80  


Thr Ser Gln Trp Leu Gln Trp Leu Tyr Pro Asn Ala Thr Pro Thr Thr 
                85                  90                  95      


Ser Ala Gln Ser Gln Ala Ala Gln Ala Val Ala Asn Leu Phe Asn Leu 
            100                 105                 110         


Ala Thr Tyr Gly Ala Val Ser Thr Arg Gly Ser Asn Ala Ala Gln Ile 
        115                 120                 125             


Leu Gln Thr Leu Gln Ser Ile Ser Pro Leu Leu Ser Pro Arg Ala Val 
    130                 135                 140                 


Gly Leu Phe Tyr Gln Ser Phe Leu Thr Glu Ile Gly Gln Ser Ser Lys 
145                 150                 155                 160 


Ala Ile Leu Ala Arg Gln Ala Ser Ser Ser Ile Val Gly Asn Ala Leu 
                165                 170                 175     


Ala Gln Ala Ala Ser Leu Ser Pro Thr Ile Ser Ala Tyr Leu Arg Gln 
            180                 185                 190         


Asn Gly Leu Ser Pro Ser Asp Leu Ala Arg Thr Trp Ser Ser Phe Glu 
        195                 200                 205             


Thr Gln Val Asp Pro Gln Gly Ala Ala Gln Thr Ala Leu Ala Thr Arg 
    210                 215                 220                 


Ile Cys Thr Asn Ala Leu Gly Phe Gly Ala Pro Thr Ala Ser Ala Thr 
225                 230                 235                 240 


Ile Thr Val Asn Thr Ala Ala Arg Leu Arg Thr Val Pro Ala Thr Ala 
                245                 250                 255     


Phe Gly Leu Asn Ala Ala Val Trp Asp Ser Gly Leu Asn Ser Gln Thr 
            260                 265                 270         


Val Ile Ser Glu Val Gln Ala Leu His Pro Ala Leu Ile Arg Trp Pro 
        275                 280                 285             


Gly Gly Ser Ile Ser Asp Val Tyr Asn Trp Glu Thr Asn Thr Arg Asn 
    290                 295                 300                 


Asp Gly Gly Tyr Val Asn Pro Asn Asp Thr Phe Asp Asn Phe Met Gln 
305                 310                 315                 320 


Phe Val Asn Ala Val Gly Ala Ser Pro Ile Ile Thr Val Asn Tyr Gly 
                325                 330                 335     


Thr Gly Thr Pro Gln Leu Ala Ala Asp Trp Val Lys Tyr Ala Asp Val 
            340                 345                 350         


Thr His His Asp Asn Val Leu Tyr Trp Glu Ile Gly Asn Glu Ile Tyr 
        355                 360                 365             


Gly Asn Gly Tyr Tyr Asn Gly Asn Gly Trp Glu Ala Asp Asp His Ala 
    370                 375                 380                 


Val Pro Asn Gln Pro Gln Lys Gly Asn Pro Gly Leu Ser Pro Gln Ala 
385                 390                 395                 400 


Tyr Ala Gln Asn Ala Leu Gln Phe Ile Gln Ala Met Arg Ala Val Asp 
                405                 410                 415     


Pro Asn Ile Lys Ile Gly Ala Val Leu Thr Met Pro Tyr Asn Trp Pro 
            420                 425                 430         


Trp Gly Ala Thr Val Asn Gly Asn Asp Asp Trp Asn Thr Val Val Leu 
        435                 440                 445             


Lys Ala Leu Gly Pro Tyr Ile Asp Phe Val Asp Val His Trp Tyr Pro 
    450                 455                 460                 


Glu Thr Pro Gly Gln Glu Thr Asp Ala Gly Leu Leu Ala Asp Thr Asp 
465                 470                 475                 480 


Gln Ile Pro Ala Met Val Ala Glu Leu Lys Arg Glu Ile Asn Ala Tyr 
                485                 490                 495     


Ala Gly Ser Asn Ala Lys Asn Ile Gln Ile Phe Val Thr Glu Thr Asn 
            500                 505                 510         


Ser Val Ser Tyr Asn Pro Gly Gln Gln Ser Thr Asn Leu Pro Glu Ala 
        515                 520                 525             


Leu Phe Leu Ala Asp Asp Leu Ala Gly Phe Val Gln Ala Gly Ala Ala 
    530                 535                 540                 


Asn Val Asp Trp Trp Asp Leu Leu Asn Gly Ala Glu Asp Asn Tyr Thr 
545                 550                 555                 560 


Ser Pro Ser Leu Tyr Gly Gln Asn Leu Phe Gly Asp Tyr Gly Leu Leu 
                565                 570                 575     


Ser Ser Gly Gln Ala Thr Pro Lys Gly Val Gln Glu Pro Pro Gln Tyr 
            580                 585                 590         


Thr Pro Leu Pro Pro Tyr Tyr Gly Phe Gln Leu Val Ser Asp Phe Ala 
        595                 600                 605             


Arg Pro Gly Asp Thr Leu Leu Gly Ser Ala Ser Ser Gln Ser Asp Ile 
    610                 615                 620                 


Asp Val His Ala Val Arg Glu Pro Asn Gly Asp Ile Ala Leu Met Leu 
625                 630                 635                 640 


Val Asn Arg Ser Pro Ser Thr Ile Tyr Ser Ala Asp Leu Asn Val Leu 
                645                 650                 655     


Gly Val Gly Pro Tyr Ala Ile Thr Lys Ala Leu Val Tyr Gly Glu Gly 
            660                 665                 670         


Ser Ser Ala Val Ser Pro Ala Leu Thr Leu Pro Thr Ala His Ser Val 
        675                 680                 685             


Lys Leu Met Pro Tyr Ser Gly Val Asp Leu Val Leu His Pro Leu Ile 
    690                 695                 700                 


Pro Ala Pro His Ala Ala Ala Ser Val Thr Asp Thr Leu Ala Leu Ser 
705                 710                 715                 720 


Ser Pro Thr Val Thr Ala Gly Gly Ser Glu Thr Val Thr Ala Ser Phe 
                725                 730                 735     


Ser Ser Asp Arg Pro Val Arg Asp Ala Thr Val Glu Leu Glu Leu Tyr 
            740                 745                 750         


Asp Ser Thr Gly Asp Leu Val Ala Asn His Glu Met Thr Gly Val Asp 
        755                 760                 765             


Ile Ala Pro Gly Gln Pro Val Ser Glu Ser Trp Thr Phe Ala Ala Pro 
    770                 775                 780                 


Ala Ala Asn Gly Thr Tyr Thr Val Glu Ala Phe Ala Phe Asp Pro Ala 
785                 790                 795                 800 


Thr Gly Ala Thr Tyr Asp Ala Asp Thr Thr Gly Ala Thr Ile Thr Val 
                805                 810                 815     


Asn Gln Pro Pro Ala Ala Lys Tyr Gly Asp Ile Val Thr Lys Asn Thr 
            820                 825                 830         


Val Ile Thr Val Asn Gly Thr Thr Tyr Thr Val Pro Ala Pro Asp Ala 
        835                 840                 845             


Ser Gly His Tyr Pro Ser Gly Thr Asn Ile Ser Ile Ala Pro Gly Asp 
    850                 855                 860                 


Thr Val Thr Ile Gln Thr Thr Phe Ala Asn Val Ser Ser Thr Asp Ala 
865                 870                 875                 880 


Leu Gln Asn Gly Leu Ile Asp Met Glu Val Asp Gly Gln Asn Gly Ala 
                885                 890                 895     


Ile Phe Gln Lys Tyr Trp Pro Ser Thr Thr Leu Leu Pro Gly Gln Thr 
            900                 905                 910         


Glu Thr Val Thr Ala Thr Trp Gln Val Pro Ser Ser Val Ser Ala Gly 
        915                 920                 925             


Thr Tyr Pro Leu Asn Phe Gln Ala Phe Asp Thr Ser Asn Trp Thr Gly 
    930                 935                 940                 


Asn Cys Tyr Phe Thr Asn Gly Gly Val Val Asn Phe Val Val Asn 
945                 950                 955                 


<210>  308
<211>  959
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<220>
<221>  CARBOHYD
<222>  (174)..(174)

<220>
<221>  CARBOHYD
<222>  (193)..(193)

<220>
<221>  CARBOHYD
<222>  (297)..(297)

<220>
<221>  CARBOHYD
<222>  (393)..(393)

<220>
<221>  CARBOHYD
<222>  (404)..(404)

<400>  308

Met Lys Arg Pro Trp Ser Ala Ala Leu Ala Ala Leu Ile Ala Leu Gly 
1               5                   10                  15      


Thr Gly Ala Ser Pro Ala Trp Ala Ala Ala His Pro Ser Pro Lys Val 
            20                  25                  30          


Pro Ala Gly Ala Ala Gly Arg Val Arg Ala Ala Asp Val Val Ser Thr 
        35                  40                  45              


Pro Ile Ser Met Glu Ile Gln Val Ile His Asp Ala Leu Thr Val Pro 
    50                  55                  60                  


Glu Leu Ala Ala Val Gln Ala Ala Ala Gln Ala Ala Ser Asn Leu Ser 
65                  70                  75                  80  


Thr Ser Gln Trp Leu Gln Trp Leu Tyr Pro Asn Ala Thr Pro Thr Thr 
                85                  90                  95      


Ser Ala Gln Ser Gln Ala Ala Gln Ala Val Ala Asn Leu Phe Asn Leu 
            100                 105                 110         


Ala Thr Tyr Gly Ala Val Ser Thr Arg Gly Ser Asn Ala Ala Gln Ile 
        115                 120                 125             


Leu Gln Thr Leu Gln Ser Ile Ser Pro Leu Leu Ser Pro Arg Ala Val 
    130                 135                 140                 


Gly Leu Phe Tyr Gln Ser Phe Leu Thr Glu Ile Gly Gln Ser Ser Lys 
145                 150                 155                 160 


Ala Ile Leu Ala Arg Gln Ala Ser Ser Ser Ile Val Gly Asn Ala Leu 
                165                 170                 175     


Ala Gln Ala Ala Ser Leu Ser Pro Thr Ile Ser Ala Tyr Leu Arg Gln 
            180                 185                 190         


Asn Gly Leu Ser Pro Ser Asp Leu Ala Arg Thr Trp Ser Ser Phe Glu 
        195                 200                 205             


Thr Gln Val Asp Pro Gln Gly Ala Ala Gln Thr Ala Leu Ala Thr Arg 
    210                 215                 220                 


Ile Cys Thr Asn Ala Leu Gly Phe Gly Ala Pro Thr Ala Ser Ala Thr 
225                 230                 235                 240 


Ile Thr Val Asn Thr Ala Ala Arg Leu Arg Thr Val Pro Ala Thr Ala 
                245                 250                 255     


Phe Gly Leu Asn Ala Ala Val Trp Asp Ser Gly Leu Asn Ser Gln Thr 
            260                 265                 270         


Val Ile Ser Glu Val Gln Ala Leu His Pro Ala Leu Ile Arg Trp Pro 
        275                 280                 285             


Gly Gly Ser Ile Ser Asp Val Tyr Asn Trp Glu Thr Asn Thr Arg Asn 
    290                 295                 300                 


Asp Gly Gly Tyr Val Asn Pro Asn Asp Thr Phe Asp Asn Phe Met Gln 
305                 310                 315                 320 


Phe Val Asn Ala Val Gly Ala Ser Pro Ile Ile Thr Val Asn Tyr Gly 
                325                 330                 335     


Thr Gly Thr Pro Gln Leu Ala Ala Asp Trp Val Lys Tyr Ala Asp Val 
            340                 345                 350         


Thr His His Asp Asn Val Leu Tyr Trp Glu Ile Gly Asn Glu Ile Tyr 
        355                 360                 365             


Gly Asn Gly Tyr Tyr Asn Gly Asn Gly Trp Glu Ala Asp Asp His Ala 
    370                 375                 380                 


Val Pro Asn Gln Pro Gln Lys Gly Asn Pro Gly Leu Ser Pro Gln Ala 
385                 390                 395                 400 


Tyr Ala Gln Asn Ala Leu Gln Phe Ile Gln Ala Met Arg Ala Val Asp 
                405                 410                 415     


Pro Asn Ile Lys Ile Gly Ala Val Leu Thr Met Pro Tyr Asn Trp Pro 
            420                 425                 430         


Trp Gly Ala Thr Val Asn Gly Asn Asp Asp Trp Asn Thr Val Val Leu 
        435                 440                 445             


Lys Ala Leu Gly Pro Tyr Ile Asp Phe Val Asp Val His Trp Tyr Pro 
    450                 455                 460                 


Glu Thr Pro Gly Gln Glu Thr Asp Ala Gly Leu Leu Ala Asp Thr Asp 
465                 470                 475                 480 


Gln Ile Pro Ala Met Val Ala Glu Leu Lys Arg Glu Ile Asn Ala Tyr 
                485                 490                 495     


Ala Gly Ser Asn Ala Lys Asn Ile Gln Ile Phe Val Thr Glu Thr Asn 
            500                 505                 510         


Ser Val Ser Tyr Asn Pro Gly Gln Gln Ser Thr Asn Leu Pro Glu Ala 
        515                 520                 525             


Leu Phe Leu Ala Asp Asp Leu Ala Gly Phe Val Gln Ala Gly Ala Ala 
    530                 535                 540                 


Asn Val Asp Trp Trp Asp Leu Leu Asn Gly Ala Glu Asp Asn Tyr Thr 
545                 550                 555                 560 


Ser Pro Ser Leu Tyr Gly Gln Asn Leu Phe Gly Asp Tyr Gly Leu Leu 
                565                 570                 575     


Ser Ser Gly Gln Ala Thr Pro Lys Gly Val Gln Glu Pro Pro Gln Tyr 
            580                 585                 590         


Thr Pro Leu Pro Pro Tyr Tyr Gly Phe Gln Leu Val Ser Asp Phe Ala 
        595                 600                 605             


Arg Pro Gly Asp Thr Leu Leu Gly Ser Ala Ser Ser Gln Ser Asp Ile 
    610                 615                 620                 


Asp Val His Ala Val Arg Glu Pro Asn Gly Asp Ile Ala Leu Met Leu 
625                 630                 635                 640 


Val Asn Arg Ser Pro Ser Thr Ile Tyr Ser Ala Asp Leu Asn Val Leu 
                645                 650                 655     


Gly Val Gly Pro Tyr Ala Ile Thr Lys Ala Leu Val Tyr Gly Glu Gly 
            660                 665                 670         


Ser Ser Ala Val Ser Pro Ala Leu Thr Leu Pro Thr Ala His Ser Val 
        675                 680                 685             


Lys Leu Met Pro Tyr Ser Gly Val Asp Leu Val Leu His Pro Leu Ile 
    690                 695                 700                 


Pro Ala Pro His Ala Ala Ala Ser Val Thr Asp Thr Leu Ala Leu Ser 
705                 710                 715                 720 


Ser Pro Thr Val Thr Ala Gly Gly Ser Glu Thr Val Thr Ala Ser Phe 
                725                 730                 735     


Ser Ser Asp Arg Pro Val Arg Asp Ala Thr Val Glu Leu Glu Leu Tyr 
            740                 745                 750         


Asp Ser Thr Gly Asp Leu Val Ala Asn His Glu Met Thr Gly Val Asp 
        755                 760                 765             


Ile Ala Pro Gly Gln Pro Val Ser Glu Ser Trp Thr Phe Ala Ala Pro 
    770                 775                 780                 


Ala Ala Asn Gly Thr Tyr Thr Val Glu Ala Phe Ala Phe Asp Pro Ala 
785                 790                 795                 800 


Thr Gly Ala Thr Tyr Asp Ala Asp Thr Thr Gly Ala Thr Ile Thr Val 
                805                 810                 815     


Asn Gln Pro Pro Ala Ala Lys Tyr Gly Asp Ile Val Thr Lys Asn Thr 
            820                 825                 830         


Val Ile Thr Val Asn Gly Thr Thr Tyr Thr Val Pro Ala Pro Asp Ala 
        835                 840                 845             


Ser Gly His Tyr Pro Ser Gly Thr Asn Ile Ser Ile Ala Pro Gly Asp 
    850                 855                 860                 


Thr Val Thr Ile Gln Thr Thr Phe Ala Asn Val Ser Ser Thr Asp Ala 
865                 870                 875                 880 


Leu Gln Asn Gly Leu Ile Asp Met Glu Val Asp Gly Gln Asn Gly Ala 
                885                 890                 895     


Ile Phe Gln Lys Tyr Trp Pro Ser Thr Thr Leu Leu Pro Gly Gln Thr 
            900                 905                 910         


Glu Thr Val Thr Ala Thr Trp Gln Val Pro Ser Ser Val Ser Ala Gly 
        915                 920                 925             


Thr Tyr Pro Leu Asn Phe Gln Ala Phe Asp Thr Ser Asn Trp Thr Gly 
    930                 935                 940                 


Asn Cys Tyr Phe Thr Asn Gly Gly Val Val Asn Phe Val Val Asn 
945                 950                 955                 

<210>   309
<211>   378
<212>   PRT
<213>   Alicyclobacillus acidocaldarius

<400>   309
Met Lys Val Ala Leu Val His Asp Trp Leu Val Asp Phe Ala Gly Ser 
                5                   10                  15      

Glu Arg Val Leu Phe Glu Leu Ala Lys Leu Phe Pro Asp Ala Pro Ile 
            20                  25                  30          

Tyr Thr Ser Val Tyr Ser Glu Arg Ala Leu Ala Asn Val Phe Pro Lys 
        35                  40                  45              

Glu Arg Val Arg Thr Ser Phe Leu Gln Lys Ile Pro Leu Ser Val Lys 
    50                  55                  60                  

Arg Tyr Arg Ser Leu Leu Pro Phe Leu Pro Phe Ala Phe Glu Met Phe 
65                  70                  75                  80  

Asp Leu Thr Gly Tyr Asp Val Ile Ile Ser Ser Ser His Ala Cys Ala 
                85                  90                  95      

Lys Gly Val Val Ala Gly Ser Asn Ser Ile His Ile Cys Tyr Cys His 
            100                 105                 110         

Thr Pro Met Arg Tyr Ala Trp Ser His Tyr His Gln Tyr Leu Arg Gly 
        115                 120                 125             

Val Arg Gly Thr Leu Lys Arg Ala Thr Val Gly Ala Ile Leu Ser Trp 
    130                 135                 140                 

Leu Arg Thr Trp Asp Phe Ile Ala Ala Gln Arg Val Asp Phe Phe Ile 
145                 150                 155                 160 

Ala Asn Ser Ser Glu Val Gln Lys Arg Ile Arg His Tyr Tyr Arg Arg 
                165                 170                 175     

Asp Ala Val Val Ile His Pro Pro Ile Ser Ala Pro Glu Gly Glu Asn 
            180                 185                 190         

Gly Asp Pro Glu Arg Ala Asp Phe Tyr Leu Tyr Leu Gly Arg Leu Val 
        195                 200                 205             

Glu Tyr Lys Arg Val Asp Leu Leu Val Asp Ala Phe Arg His Leu Pro 
    210                 215                 220                 

Ser Ala Arg Leu Ile Val Ala Gly Asp Gly Pro Glu Met Asn Arg Leu 
225                 230                 235                 240 

Arg Arg Ser Ala Pro Leu Asn Val Glu Phe Ala Gly Lys Val Thr Glu 
                245                 250                 255     

Asp Glu Lys Trp Asp Leu Leu Arg Arg Ala Lys Ala Leu Leu Phe Pro 
            260                 265                 270         

Ala His Glu Asp Phe Gly Ile Val Ile Gly Glu Ala Arg Ala Val Gly 
        275                 280                 285             

Thr Pro Val Ile Gly Leu Ala Gln Gly Gly Val Leu Asp Tyr Ala Gly 
    290                 295                 300                 

Asp Pro Gly Val Leu Pro Trp Ile Lys Arg Gln Asn Leu Asp Asp Val 
305                 310                 315                 320 

Lys Met Ala Val Asp Arg Phe Glu Arg Glu Ser Phe Asn Ser Asp Val 
                325                 330                 335     

Tyr Glu Lys Tyr Leu Ile Gln Thr Glu Asp Ser Phe Arg Asn Ala Val 
            340                 345                 350         

Ala Arg Leu Val Asp Asp Leu Val Ala Asn Lys Lys Gly Glu Ser Arg 
        355                 360                 365             

Val Gly Arg Ala Ala Asp Ala Arg Asp His 
    370                 375             

<210>   310
<211>   1137
<212>   DNA
<213>   Alicyclobacillus acidocaldarius

<400>   310
gtgaaggtgg cattggtcca cgactggcta gttgatttcg cgggatcaga acgagttttg       60

tttgaacttg cgaagttgtt cccagatgcg ccaatctata cgtctgtcta tagcgaacgt      120

gctctcgcca atgtgtttcc gaaggaacgt gtgcgcacaa gttttttgca gaagataccg      180

ttgtcagtca agcgctatcg gtcattgttg ccgttcctac catttgcctt cgaaatgttc      240

gatttgacgg ggtatgatgt catcatctcg agttcacacg catgtgccaa aggcgtcgtt      300

gctggatcga atagtattca tatctgttat tgtcatacgc cgatgcgata cgcgtggagt      360

cactatcatc agtacctgag aggcgttcgc ggaacgctca aacgggctac cgtcggagcc      420

atcctttcat ggttgagaac atgggatttt atagctgctc aaagagttga tttcttcatt      480

gcgaattctt ctgaagtcca gaaacgaatc cggcattact atcgtagaga cgccgttgtg      540

atccatccgc ctatttcagc tcctgaaggc gaaaacggcg atccagagag agcagatttc      600

tatttgtatc tgggtcgttt agtcgagtat aagcgggtgg acttgcttgt ggacgctttt      660

cgccacctgc cgtctgcaag attgattgtg gcaggagatg gaccagagat gaatcgcctt      720

cgccgttcag ctccgctcaa cgtagagttc gcagggaagg tcacagaaga tgaaaaatgg      780

gatctgttga ggcgggcgaa ggctttgttg tttccagcac acgaggattt tggtatcgtg      840

attggggaag ccagagcagt tgggacgccc gtgatcggac ttgcacaagg gggcgttttg      900

gactacgcag gcgatcctgg tgtgctcccc tggattaaaa ggcaaaacct agacgatgtt      960

aaaatggccg tcgaccgatt tgaaagggaa tccttcaatt cggatgtcta cgagaagtac     1020

ctcattcaaa ccgaggatag ttttcgaaac gccgtcgcca ggcttgttga cgatttggtg     1080

gcgaacaaga aaggtgagtc gcgtgttggg cgtgcagcgg atgcgcgaga tcattga        1137


<210>   311
<211>   362
<212>   PRT
<213>   Thermoanaerobacter sp. X514

<400>   311
Met Lys Ile Ala Ile Ile His Asp Trp Leu Thr Asn Met Gly Gly Ala 
                5                   10                  15      

Glu Arg Val Ile Leu Ala Phe His Glu Ile Phe Pro Asp Ala Pro Ile 
            20                  25                  30          

Tyr Thr Ser Val Tyr Asn Pro Asp Lys Leu Pro Glu Glu Phe Arg Lys 
        35                  40                  45              

Met Asp Ile Arg Thr Ser Phe Ile Gln Lys Leu Pro Lys Ala Lys Thr 
    50                  55                  60                  

Lys Tyr Asn Ile Tyr Leu Pro Leu Met Pro Val Ala Phe Glu Gln Phe 
65                  70                  75                  80  

Asp Leu Ser Glu Tyr Asp Val Val Leu Ser Ser Ser Ser Ser Cys Ala 
                85                  90                  95      

Lys Gly Val Ile Thr Arg Ala Asp Thr Leu His Ile Cys Tyr Cys His 
            100                 105                 110         

Thr Pro Met Arg Tyr Ala Trp Asp Phe Tyr His Glu Tyr Lys Gln Asn 
        115                 120                 125             

Ala Pro Lys Trp Gln Arg Lys Phe Ile Pro Phe Leu Met Asn Tyr Ile 
    130                 135                 140                 

Arg Met Trp Asp Arg Leu Ser Ala Asp Arg Val Asp Tyr Phe Ile Ala 
145                 150                 155                 160 

Asn Ser Ser Ala Val Ala Arg Arg Ile Lys Lys His Tyr Arg Arg Asp 
                165                 170                 175     

Ala Val Val Ile Asn Pro Pro Val Asp Thr Asn Phe Tyr Thr Pro Lys 
            180                 185                 190         

Asp Glu Asp Glu Asp Tyr Phe Leu Ile Val Ser Arg Leu Val Glu Tyr 
        195                 200                 205             

Lys Arg Ile Asp Ile Ala Ile Glu Ala Phe Asn Asp Leu Gly Leu Pro 
    210                 215                 220                 

Leu Ile Ile Ile Gly Asp Gly Pro Glu Arg Ser Lys Leu Gln Lys Met 
225                 230                 235                 240 

Ala Lys Ser Asn Ile Arg Phe Leu Gly Arg Leu Pro Asp Glu Glu Val 
                245                 250                 255     

Lys Glu Tyr Tyr Ala Lys Cys Arg Ala Phe Ile Phe Pro Gly Glu Glu 
            260                 265                 270         

Asp Phe Gly Ile Thr Pro Leu Glu Ala Gln Ala Ser Gly Arg Pro Val 
        275                 280                 285             

Ile Ala Phe Gly Lys Gly Gly Val Leu Asp Ser Val Ile Asp Gly Leu 
    290                 295                 300                 

Thr Gly Ile Phe Phe Lys Asp Gln Asn Lys Glu Ser Leu Lys Glu Ala 
305                 310                 315                 320 

Ile Lys Arg Phe Glu Lys Ile Asp Phe Ser Lys Glu Thr Ile Arg Lys 
                325                 330                 335     

His Ala Glu Lys Phe Asp Val Lys Ile Phe Lys Lys Lys Ile Tyr Asp 
            340                 345                 350         

Phe Ile Ile Asn Lys Tyr Asn Asp Tyr Arg 
        355                 360         

<210>   312
<211>   374
<212>   PRT
<213>   Caldicellulosiruptor saccharolyticus DSM 8903

<400>   312
Met Lys Val Ala Ile Val His Glu Trp Leu Thr Thr Met Gly Gly Ser 
                5                   10                  15      

Glu Lys Val Ile Leu Glu Leu Lys Lys Leu Phe Pro Glu Ala Pro Ile 
            20                  25                  30          

Tyr Thr Leu Val Tyr Asn Arg Arg Lys Leu Gly Lys Tyr Phe Asp Lys 
        35                  40                  45              

Tyr Leu Ile Ile Thr Ser Asn Leu Gln Lys Asn Pro Leu Ala His Ile 
    50                  55                  60                  

Lys His Gln Leu Phe Phe Lys Tyr Met Pro Arg Ala Phe Glu Asn Phe 
65                  70                  75                  80  

Asp Leu Ser Asp Phe Asp Leu Val Ile Ser Ser Ser Ser Ala Phe Ala 
                85                  90                  95      

Lys Gly Val Ile Thr Ser Pro Asn Ser Val His Ile Cys Tyr Cys His 
            100                 105                 110         

Thr Pro Pro Arg Tyr Leu Trp Asp Leu Thr His Glu Tyr Leu Lys Asp 
        115                 120                 125             

Tyr Asn Leu Ile Ile Arg Arg Tyr Leu Glu Arg Asn Phe His Tyr Leu 
    130                 135                 140                 

Arg Ile Trp Asp Thr Ile Ala Ala Asn Arg Val Asp Tyr Phe Val Ala 
145                 150                 155                 160 

Asn Ser Asn Tyr Val Ala Asn Arg Ile Lys Lys Phe Tyr Lys Arg Asp 
                165                 170                 175     

Cys Lys Val Ile Tyr Pro Pro Val Asp Thr Glu Tyr Phe Thr Pro Ala 
            180                 185                 190         

Lys Asp Lys Asn Ile Glu Asp Tyr Tyr Leu Ile Val Ser Arg Leu Val 
        195                 200                 205             

Pro Tyr Lys Arg Val Asp Leu Ala Val Glu Ala Phe Asn Gln Leu Ser 
    210                 215                 220                 

Lys Arg Leu Val Ile Val Gly Asp Gly Pro Glu Tyr Lys Lys Leu Lys 
225                 230                 235                 240 

Ser Ile Ala Lys Ser Asn Ile Glu Phe Leu Gly Tyr Gln Pro Asp Lys 
                245                 250                 255     

Thr Val Arg Asp Leu Tyr Gln Arg Cys Lys Ala Leu Ile Phe Pro Gly 
            260                 265                 270         

Val Glu Asp Phe Gly Ile Val Pro Val Glu Val Gln Ala Cys Gly Arg 
        275                 280                 285             

Pro Val Ile Ala Leu Lys Lys Gly Gly Ala Val Glu Thr Val Glu Glu 
    290                 295                 300                 

Gly Lys Thr Gly Val Phe Phe Glu Lys Gln Asp Val Glu Ser Leu Lys 
305                 310                 315                 320 

Glu Ala Val Tyr Lys Phe Glu Gln Asp Ile Glu Arg Phe Asp Lys Asp 
                325                 330                 335     

Tyr Ile Arg Ser His Ala Glu Lys Phe Ser Ala Glu Arg Phe Arg Met 
            340                 345                 350         

Glu Phe Lys Asp Phe Ile Leu Lys Val Thr Glu Tyr Glu Arg Gly Glu 
        355                 360                 365             

Gly Met Gly Gly Lys Val 
    370                 

<210>   313
<211>   357
<212>   PRT
<213>   Mesorhizobium sp. BNC1

<400>   313
Val Arg Val Ala Ile Val His Tyr Trp Leu Val Ser Met Arg Gly Gly 
                5                   10                  15      

Glu Lys Val Val Glu Ala Phe Cys Asp Met Tyr Pro Asp Ala Asp Ile 
            20                  25                  30          

Phe Thr Leu Val Tyr Asp Glu Arg Lys Val Ser Glu Lys Ile Arg Arg 
        35                  40                  45              

His Lys Val Thr Thr Ser Phe Leu Gln Lys Ile Pro Gly Ala Val Lys 
    50                  55                  60                  

His Tyr Gln Ser Leu Leu Pro Leu Met Pro Phe Ala Leu Glu Ser Phe 
65                  70                  75                  80  

Asp Leu Ser Gly Tyr Asp Leu Ile Leu Ser Ser Glu Ser Gly Pro Ala 
                85                  90                  95      

Lys Gly Ile Val Pro Gly Pro Gln Ala Val His Ile Cys Tyr Cys His 
            100                 105                 110         

Ser Pro Met Arg Tyr Leu Trp Asp His Tyr His Phe Tyr Arg Ala Asn 
        115                 120                 125             

Ser Gly Met Leu Ala Arg Ala Leu Leu Thr Met Met Ala Pro Pro Leu 
    130                 135                 140                 

Arg Ala Trp Asp Val Ser Thr Ser Ala Arg Val Asp His Phe Val Ala 
145                 150                 155                 160 

Asn Ser Arg His Val Ala Asp Arg Ile Glu Lys Tyr Tyr Arg Arg Ser 
                165                 170                 175     

Ala Thr Val Leu Ser Pro Pro Val Ser Val His Glu Phe Ala Pro Thr 
            180                 185                 190         

Ala Ala Thr Lys Asp Phe Phe Leu Leu Ala Gly Gln Leu Val Gly Tyr 
        195                 200                 205             

Lys Arg Ala Asp Leu Ala Val Glu Ala Phe Thr Lys Met Gly Glu Asn 
    210                 215                 220                 

Leu Val Val Ile Gly Glu Gly Ser Glu Met Asp Lys Leu Arg Arg Ile 
225                 230                 235                 240 

Ala Gly Pro Thr Val Ser Phe Leu Gly Arg Ala Pro Phe Pro Leu Leu 
                245                 250                 255     

Lys Glu Met Leu Ala Arg Cys Arg Ala Leu Val Phe Pro Gly Glu Glu 
            260                 265                 270         

Asp Phe Gly Ile Val Pro Val Glu Ala Met Ala Ser Gly Arg Pro Val 
        275                 280                 285             

Ile Ala Tyr Gly Arg Gly Gly Ala Leu Asp Ser Val Ser Pro Gly Arg 
    290                 295                 300                 

Thr Gly Ile Leu Phe His Glu Gln Thr Val Pro Ser Leu Ile Glu Ala 
305                 310                 315                 320 

Val Arg Arg Phe Gln Ser Met Glu Arg Thr Phe Arg Pro Asp Val Ile 
                325                 330                 335     

Arg Asp His Ala Ala Gln Phe Ser Glu Ala Asn Phe Lys Ala Arg Met 
            340                 345                 350         

Gln Gln Ile Ile Asp 
        355         

<210>   314
<211>   363
<212>   PRT
<213>   Dictyoglomus turgidum DSM 6724

<400>   314
Met Arg Val Ala Val Val His Asp Trp Ile Val Asn Ile Gly Gly Ala 
                5                   10                  15      

Glu Lys Val Leu Lys Ala Ile Leu Glu Leu Phe Pro Asp Ala Asp Val 
            20                  25                  30          

Tyr Thr Leu Val Tyr Leu Lys Asp Thr Leu Arg Lys Leu Gly Ile Asn 
        35                  40                  45              

Asn Lys Val Tyr Ser Ser Phe Ile Ser Gly Leu Pro Phe Ala Lys Thr 
    50                  55                  60                  

Lys Tyr Ser Tyr Tyr Leu Pro Leu Met Pro Leu Ala Ile Glu Gln Phe 
65                  70                  75                  80  

Asp Leu Ser Lys Tyr Asp Leu Val Ile Ser Ser Ser His Cys Val Ala 
                85                  90                  95      

Lys Gly Val Leu Thr Lys Ser Tyr Gln Ile His Ile Cys Tyr Cys His 
            100                 105                 110         

Thr Pro Met Arg Tyr Ile Trp Asp Leu Tyr Phe Pro Tyr Leu Lys Glu 
        115                 120                 125             

His Lys Leu Glu Asn Gly Ile Lys Gly Ile Phe Val Lys Pro Ile Leu 
    130                 135                 140                 

His Tyr Leu Arg Ile Trp Asp Val Ser Ser Ala Asn Arg Val Asp Tyr 
145                 150                 155                 160 

Phe Val Ala Asn Ser Gln Asn Val Ala Asn Arg Ile Arg Lys Ile Tyr 
                165                 170                 175     

Arg Arg Asp Ser Val Val Ile Tyr Pro Pro Val Asp Val Glu Arg Phe 
            180                 185                 190         

Leu Pro Ser Tyr Lys Lys Glu Asp Tyr Phe Met Val Leu Ser Arg Leu 
        195                 200                 205             

Val Pro Tyr Lys Lys Val Asp Leu Val Val Glu Thr Phe Asn Glu Leu 
    210                 215                 220                 

Asn Leu Pro Leu Val Val Ile Gly Asp Gly Glu Glu Met Gly Lys Ile 
225                 230                 235                 240 

Lys Lys Met Ala Lys Glu Asn Ile Lys Ile Leu Gly Trp Gln Glu Asp 
                245                 250                 255     

Asp Val Val Lys Glu Tyr Leu Ala Lys Ala Gln Ala Leu Ile Phe Ala 
            260                 265                 270         

Ser Glu Glu Asp Phe Gly Ile Val Ser Val Glu Ala Gln Ala Cys Gly 
        275                 280                 285             

Thr Pro Val Ile Ala Tyr Asn Arg Gly Gly Ala Lys Glu Thr Val Ile 
    290                 295                 300                 

Asp Gly Glu Thr Gly Ile Leu Phe Glu Glu Gln Asn Val Glu Ser Leu 
305                 310                 315                 320 

Lys Lys Ala Val Leu Arg Phe Leu Lys Glu Arg Asp Asn Phe Gln Arg 
                325                 330                 335     

Asp Lys Ile Met Glu Asn Ala Lys Arg Phe Ser Glu Asp Arg Phe Lys 
            340                 345                 350         

Arg Glu Phe Lys Ser Tyr Ile Glu Gly Ile Ile 
        355                 360             

<210>   315
<211>   336
<212>   PRT
<213>   Desulfotomaculum reducens MI-1

<400>   315
Met Lys Thr Ala Phe Ile His Asp Trp Leu Val Thr Tyr Ala Gly Ala 
                5                   10                  15      

Glu Arg Val Leu Glu Gln Met Leu Lys Ile Phe Pro Asp Ala Asp Leu 
            20                  25                  30          

Tyr Ser Val Val Asp Phe Ile Pro Tyr Asn Gln Arg Ser Phe Leu Gln 
        35                  40                  45              

Glu Lys Leu Ser Gln Thr Ser Phe Ile Gln Lys Leu Pro Phe Ala Lys 
    50                  55                  60                  

Lys Lys Tyr Arg Ser Tyr Leu Pro Leu Met Pro Leu Ala Val Glu Gln 
65                  70                  75                  80  

Leu Asp Leu Ser Ala Tyr Asp Leu Ile Ile Ser Asn Ser His Ala Val 
                85                  90                  95      

Ala Lys Gly Val Ile Thr Gly Pro Asp Gln Leu His Leu Ser Tyr Val 
            100                 105                 110         

Asn Ser Pro Met Arg Tyr Ala Trp Asp Leu Gln His Gln Tyr Leu Gln 
        115                 120                 125             

Glu Ala Lys Leu Asn Arg Gly Leu Lys Gly Trp Thr Ala Lys Val Leu 
    130                 135                 140                 

Leu His Tyr Leu Arg Met Trp Asp Ile Arg Thr Ala Asn Gly Val Asp 
145                 150                 155                 160 

Ser Phe Thr Ala Asn Ser Cys Phe Ile Ser Arg Arg Ile Trp Lys Val 
                165                 170                 175     

Tyr His Arg Glu Ala Lys Val Ile Tyr Pro Pro Val Ala Val Asp Glu 
            180                 185                 190         

Phe Asp Val Gly Glu Tyr Lys Glu Asp Phe Tyr Leu Thr Ile Ser Arg 
        195                 200                 205             

Met Val Pro Tyr Lys Lys Met Asp Leu Ile Val Glu Ala Phe Ser Gln 
    210                 215                 220                 

Arg Pro Asp Lys Asn Leu Ile Val Ile Gly Asp Gly Pro Asp Phe Asn 
225                 230                 235                 240 

Lys Val Lys Ala Lys Ala Lys Ser Asn Val Thr Leu Leu Gly Tyr Gln 
                245                 250                 255     

Pro Phe Asp Gln Leu Lys Asp Tyr Met Gln Arg Ala Lys Ala Phe Val 
            260                 265                 270         

Phe Ala Ala Glu Glu Asp Phe Gly Ile Thr Pro Val Glu Ala Gln Ala 
        275                 280                 285             

Cys Gly Thr Pro Val Ile Ala Phe Gly Arg Gly Gly Ala Leu Glu Thr 
    290                 295                 300                 

Ile Arg Gly Leu Asp Asn Pro Ser Pro Thr Gly Val Phe Phe Arg Gln 
305                 310                 315                 320 

Gln Thr Val Glu Ser Leu Leu Ser Ala Val Asp Leu Phe Glu Arg Glu 
                325                 330                 335     

<210>   316
<211>   378
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 309

<400>   316
Met Lys Val Ala Leu Val His Asp Trp Leu Val Asp Phe Ala Gly Ser 
                5                   10                  15      

Glu Arg Val Leu Phe Glu Leu Ala Lys Leu Phe Pro Asp Ala Pro Ile 
            20                  25                  30          

Tyr Thr Ser Val Tyr Ser Glu Arg Ala Leu Ala Asn Val Phe Pro Lys 
        35                  40                  45              

Glu Arg Val Arg Thr Ser Phe Leu Gln Lys Ile Pro Leu Ser Val Lys 
    50                  55                  60                  

Arg Tyr Arg Ser Leu Leu Pro Phe Leu Pro Phe Ala Phe Glu Met Phe 
65                  70                  75                  80  

Asp Leu Thr Gly Tyr Asp Val Ile Ile Ser Ser Ser His Ala Cys Ala 
                85                  90                  95      

Lys Gly Val Val Ala Gly Ser Asn Ser Ile His Ile Cys Tyr Cys His 
            100                 105                 110         

Thr Pro Met Arg Tyr Ala Trp Ser His Tyr His Gln Tyr Leu Arg Gly 
        115                 120                 125             

Val Arg Gly Thr Leu Lys Arg Ala Thr Val Gly Ala Ile Leu Ser Trp 
    130                 135                 140                 

Leu Arg Thr Trp Asp Phe Ile Ala Ala Gln Arg Val Asp Phe Phe Ile 
145                 150                 155                 160 

Ala Asn Ser Ser Glu Val Gln Lys Arg Ile Arg His Tyr Tyr Arg Arg 
                165                 170                 175     

Asp Ala Val Val Ile His Pro Pro Ile Ser Ala Pro Glu Gly Glu Asn 
            180                 185                 190         

Gly Asp Pro Glu Arg Ala Asp Phe Tyr Leu Tyr Leu Gly Arg Leu Val 
        195                 200                 205             

Glu Tyr Lys Arg Val Asp Leu Leu Val Asp Ala Phe Arg His Leu Pro 
    210                 215                 220                 

Ser Ala Arg Leu Ile Val Ala Gly Asp Gly Pro Glu Met Asn Arg Leu 
225                 230                 235                 240 

Arg Arg Ser Ala Pro Leu Asn Val Glu Phe Ala Gly Lys Val Thr Glu 
                245                 250                 255     

Asp Glu Lys Trp Asp Leu Leu Arg Arg Ala Lys Ala Leu Leu Phe Pro 
            260                 265                 270         

Ala His Glu Asp Phe Gly Ile Val Ile Gly Glu Ala Arg Ala Val Gly 
        275                 280                 285             

Thr Pro Val Ile Gly Leu Ala Gln Gly Gly Val Leu Asp Tyr Ala Gly 
    290                 295                 300                 

Asp Pro Gly Val Leu Pro Trp Ile Lys Arg Gln Asn Leu Glu Asp Val 
305                 310                 315                 320 

Lys Met Ala Val Asp Arg Phe Glu Arg Glu Ser Phe Asn Ser Asp Val 
                325                 330                 335     

Tyr Glu Lys Tyr Leu Ile Gln Thr Glu Asp Ser Phe Arg Asn Ala Val 
            340                 345                 350         

Ala Arg Leu Val Asp Asp Leu Val Ala Asn Lys Lys Gly Glu Ser Arg 
        355                 360                 365             

Val Gly Arg Ala Ala Asp Ala Arg Asp His 
    370                 375             

<210>   317
<211>   378
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 309

<400>   317
Met Lys Val Ala Leu Val His Asp Trp Leu Val Asp Phe Ala Gly Ser 
                5                   10                  15      

Glu Arg Val Leu Phe Glu Leu Ala Lys Leu Phe Pro Asp Ala Pro Ile 
            20                  25                  30          

Tyr Thr Ser Val Tyr Ser Glu Arg Ala Leu Ala Asn Val Phe Pro Lys 
        35                  40                  45              

Glu Arg Val Arg Thr Ser Phe Leu Gln Lys Ile Pro Leu Ser Val Lys 
    50                  55                  60                  

Arg Tyr Arg Ser Leu Leu Pro Phe Leu Pro Phe Ala Phe Glu Met Phe 
65                  70                  75                  80  

Asp Leu Thr Gly Tyr Asp Val Ile Ile Ser Ser Ser His Ala Cys Ala 
                85                  90                  95      

Lys Gly Val Val Ala Gly Ser Asn Ser Ile His Ile Cys Tyr Cys His 
            100                 105                 110         

Thr Pro Met Arg Tyr Ala Trp Ser His Tyr His Gln Tyr Leu Arg Gly 
        115                 120                 125             

Val Arg Gly Thr Leu Lys Arg Ala Thr Val Gly Ala Ile Leu Ser Trp 
    130                 135                 140                 

Leu Arg Thr Trp Asp Phe Ile Ala Ala Gln Arg Val Asp Phe Phe Ile 
145                 150                 155                 160 

Ala Asn Ser Ser Glu Val Gln Lys Arg Ile Arg His Tyr Tyr Arg Arg 
                165                 170                 175     

Asp Ala Val Val Ile His Pro Pro Ile Ser Ala Pro Glu Gly Glu Asn 
            180                 185                 190         

Gly Asp Pro Glu Arg Ala Asp Phe Tyr Leu Tyr Leu Gly Arg Leu Val 
        195                 200                 205             

Glu Tyr Lys Arg Val Asp Leu Leu Val Asp Ala Phe Arg His Leu Pro 
    210                 215                 220                 

Ser Ala Arg Leu Ile Val Ala Gly Asp Gly Pro Glu Met Asn Arg Leu 
225                 230                 235                 240 

Arg Arg Ser Ala Pro Leu Asn Val Glu Phe Ala Gly Lys Val Thr Glu 
                245                 250                 255     

Asp Glu Lys Trp Asp Leu Leu Arg Arg Ala Lys Ala Leu Leu Phe Pro 
            260                 265                 270         

Ala His Glu Asp Phe Gly Ile Val Ile Gly Glu Ala Arg Ala Val Gly 
        275                 280                 285             

Thr Pro Val Ile Gly Leu Ala Gln Gly Gly Val Leu Asp Tyr Ala Gly 
    290                 295                 300                 

Asp Pro Gly Val Leu Pro Trp Ile Lys Arg Gln Asn Leu Asp Asp Val 
305                 310                 315                 320 

Lys Met Ala Val Asp Arg Phe Glu Arg Glu Ser Phe Asn Ser Asp Ile 
                325                 330                 335     

Tyr Glu Lys Tyr Leu Ile Gln Thr Glu Asp Ser Phe Arg Asn Ala Val 
            340                 345                 350         

Ala Arg Leu Val Asp Asp Leu Val Ala Asn Lys Lys Gly Glu Ser Arg 
        355                 360                 365             

Val Gly Arg Ala Ala Asp Ala Arg Asp His 
    370                 375             

<210>   318
<211>   378
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 309

<400>   318
Met Lys Val Ala Leu Val His Asp Trp Leu Val Asp Phe Ala Gly Ser 
                5                   10                  15      

Glu Arg Val Leu Phe Glu Leu Ala Lys Leu Phe Pro Asp Ala Pro Ile 
            20                  25                  30          

Tyr Thr Ser Val Tyr Ser Glu Arg Ala Leu Ala Asn Val Phe Pro Lys 
        35                  40                  45              

Glu Arg Val Arg Thr Ser Phe Leu Gln Lys Ile Pro Leu Ser Val Lys 
    50                  55                  60                  

Arg Tyr Arg Ser Leu Leu Pro Phe Leu Pro Phe Ala Phe Glu Met Phe 
65                  70                  75                  80  

Asp Leu Thr Gly Tyr Asp Val Ile Ile Ser Ser Ser His Ala Cys Ala 
                85                  90                  95      

Lys Gly Val Val Ala Gly Ser Asn Ser Ile His Ile Cys Tyr Cys His 
            100                 105                 110         

Thr Pro Met Arg Tyr Ala Trp Ser His Tyr His Gln Tyr Leu Arg Gly 
        115                 120                 125             

Val Arg Gly Thr Leu Lys Arg Ala Thr Val Gly Ala Ile Leu Ser Trp 
    130                 135                 140                 

Leu Arg Thr Trp Asp Phe Ile Ala Ala Gln Arg Val Asp Phe Phe Ile 
145                 150                 155                 160 

Ala Asn Ser Ser Glu Val Asn Lys Arg Ile Arg His Tyr Tyr Arg Arg 
                165                 170                 175     

Asp Ala Val Val Ile His Pro Pro Ile Ser Ala Pro Glu Gly Glu Asn 
            180                 185                 190         

Gly Asp Pro Glu Arg Ala Asp Phe Tyr Leu Tyr Leu Gly Arg Leu Val 
        195                 200                 205             

Glu Tyr Lys Arg Val Asp Leu Leu Val Asp Ala Phe Arg His Leu Pro 
    210                 215                 220                 

Ser Ala Arg Leu Ile Val Ala Gly Asp Gly Pro Glu Met Asn Arg Leu 
225                 230                 235                 240 

Arg Arg Ser Ala Pro Leu Asn Val Glu Phe Ala Gly Lys Val Thr Glu 
                245                 250                 255     

Asp Glu Lys Trp Asp Leu Leu Arg Arg Ala Lys Ala Leu Leu Phe Pro 
            260                 265                 270         

Ala His Glu Asp Phe Gly Ile Val Ile Gly Glu Ala Arg Ala Val Gly 
        275                 280                 285             

Thr Pro Val Ile Gly Leu Ala Gln Gly Gly Val Leu Asp Tyr Ala Gly 
    290                 295                 300                 

Asp Pro Gly Val Leu Pro Trp Ile Lys Arg Gln Asn Leu Asp Asp Val 
305                 310                 315                 320 

Lys Met Ala Val Asp Arg Phe Glu Arg Glu Ser Phe Asn Ser Asp Val 
                325                 330                 335     

Tyr Glu Lys Tyr Leu Ile Gln Thr Glu Asp Ser Phe Arg Asn Ala Val 
            340                 345                 350         

Ala Arg Leu Val Asp Asp Leu Val Ala Asn Lys Lys Gly Glu Ser Arg 
        355                 360                 365             

Val Gly Arg Ala Ala Asp Ala Arg Asp His 
    370                 375             

<210>   319
<211>   378
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 309

<400>   319
Met Lys Val Ala Leu Val His Asp Trp Leu Val Asp Phe Ala Gly Ser 
                5                   10                  15      

Glu Arg Val Leu Phe Glu Leu Ala Lys Leu Phe Pro Asp Ala Pro Ile 
            20                  25                  30          

Tyr Thr Ser Val Tyr Ser Glu Arg Ala Leu Ala Asn Val Phe Pro Lys 
        35                  40                  45              

Glu Arg Val Arg Thr Ser Phe Leu Gln Lys Ile Pro Leu Ser Val Lys 
    50                  55                  60                  

Arg Tyr Arg Ser Leu Leu Pro Phe Leu Pro Phe Ala Phe Glu Met Phe 
65                  70                  75                  80  

Asp Leu Thr Gly Tyr Asp Val Ile Ile Ser Ser Ser His Ala Cys Ala 
                85                  90                  95      

Lys Gly Val Val Ala Gly Ser Asn Ser Ile His Ile Cys Tyr Cys His 
            100                 105                 110         

Thr Pro Met Arg Tyr Ala Trp Ser His Tyr His Gln Tyr Leu Arg Gly 
        115                 120                 125             

Ile Arg Gly Thr Leu Lys Arg Ala Thr Val Gly Ala Ile Leu Ser Trp 
    130                 135                 140                 

Leu Arg Thr Trp Asp Phe Ile Ala Ala Gln Arg Val Asp Phe Phe Ile 
145                 150                 155                 160 

Ala Asn Ser Ser Glu Val Gln Lys Arg Ile Arg His Tyr Tyr Arg Arg 
                165                 170                 175     

Asp Ala Val Val Ile His Pro Pro Ile Ser Ala Pro Glu Gly Glu Asn 
            180                 185                 190         

Gly Asp Pro Glu Arg Ala Asp Phe Tyr Leu Tyr Leu Gly Arg Leu Val 
        195                 200                 205             

Glu Tyr Lys Arg Val Asp Leu Leu Val Asp Ala Phe Arg His Leu Pro 
    210                 215                 220                 

Ser Ala Arg Leu Ile Val Ala Gly Asp Gly Pro Glu Met Asn Arg Leu 
225                 230                 235                 240 

Arg Arg Ser Ala Pro Leu Asn Val Glu Phe Ala Gly Lys Val Thr Glu 
                245                 250                 255     

Asp Glu Lys Trp Asp Leu Leu Arg Arg Ala Lys Ala Leu Leu Phe Pro 
            260                 265                 270         

Ala His Glu Asp Phe Gly Ile Val Ile Gly Glu Ala Arg Ala Val Gly 
        275                 280                 285             

Thr Pro Val Ile Gly Leu Ala Gln Gly Gly Val Leu Asp Tyr Ala Gly 
    290                 295                 300                 

Asp Pro Gly Val Leu Pro Trp Ile Lys Arg Gln Asn Leu Asp Asp Val 
305                 310                 315                 320 

Lys Met Ala Val Asp Arg Phe Glu Arg Glu Ser Phe Asn Ser Asp Val 
                325                 330                 335     

Tyr Glu Lys Tyr Leu Ile Gln Thr Glu Asp Ser Phe Arg Asn Ala Val 
            340                 345                 350         

Ala Arg Leu Val Asp Asp Leu Val Ala Asn Lys Lys Gly Glu Ser Arg 
        355                 360                 365             

Val Gly Arg Ala Ala Asp Ala Arg Asp His 
    370                 375             

<210>   320
<211>   378
<212>   PRT
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 309

<400>   320
Met Lys Val Ala Leu Val His Asp Trp Leu Val Asp Phe Ala Gly Ser 
                5                   10                  15      

Glu Arg Val Leu Phe Glu Leu Ala Lys Leu Phe Pro Asp Ala Pro Ile 
            20                  25                  30          

Tyr Thr Ser Val Tyr Ser Glu Arg Ala Leu Ala Asn Val Phe Pro Lys 
        35                  40                  45              

Glu Arg Val Arg Thr Ser Phe Leu Gln Lys Ile Pro Leu Ser Val Lys 
    50                  55                  60                  

Arg Tyr Arg Ser Leu Leu Pro Phe Leu Pro Phe Ala Phe Glu Met Phe 
65                  70                  75                  80  

Asp Leu Thr Gly Tyr Asp Val Ile Ile Ser Ser Ser His Ala Cys Ala 
                85                  90                  95      

Lys Gly Val Val Ala Gly Ser Asn Ser Ile His Ile Cys Tyr Cys His 
            100                 105                 110         

Thr Pro Met Arg Tyr Ala Trp Ser His Tyr His Gln Tyr Leu Arg Gly 
        115                 120                 125             

Val Arg Gly Thr Leu Lys Lys Ala Thr Val Gly Ala Ile Leu Ser Trp 
    130                 135                 140                 

Leu Arg Thr Trp Asp Phe Ile Ala Ala Gln Arg Val Asp Phe Phe Ile 
145                 150                 155                 160 

Ala Asn Ser Ser Glu Val Gln Lys Arg Ile Arg His Tyr Tyr Arg Arg 
                165                 170                 175     

Asp Ala Val Val Ile His Pro Pro Ile Ser Ala Pro Glu Gly Glu Asn 
            180                 185                 190         

Gly Asp Pro Glu Arg Ala Asp Phe Tyr Leu Tyr Leu Gly Arg Leu Val 
        195                 200                 205             

Glu Tyr Lys Arg Val Asp Leu Leu Val Asp Ala Phe Arg His Leu Pro 
    210                 215                 220                 

Ser Ala Arg Leu Ile Val Ala Gly Asp Gly Pro Glu Met Asn Arg Leu 
225                 230                 235                 240 

Arg Arg Ser Ala Pro Leu Asn Val Glu Phe Ala Gly Lys Val Thr Glu 
                245                 250                 255     

Asp Glu Lys Trp Asp Leu Leu Arg Arg Ala Lys Ala Leu Leu Phe Pro 
            260                 265                 270         

Ala His Glu Asp Phe Gly Ile Val Ile Gly Glu Ala Arg Ala Val Gly 
        275                 280                 285             

Thr Pro Val Ile Gly Leu Ala Gln Gly Gly Val Leu Asp Tyr Ala Gly 
    290                 295                 300                 

Asp Pro Gly Val Leu Pro Trp Ile Lys Arg Gln Asn Leu Asp Asp Val 
305                 310                 315                 320 

Lys Met Ala Val Asp Arg Phe Glu Arg Glu Ser Phe Asn Ser Asp Val 
                325                 330                 335     

Tyr Glu Lys Tyr Leu Ile Gln Thr Glu Asp Ser Phe Arg Asn Ala Val 
            340                 345                 350         

Ala Arg Leu Val Asp Asp Leu Val Ala Asn Lys Lys Gly Glu Ser Arg 
        355                 360                 365             

Val Gly Arg Ala Ala Asp Ala Arg Asp His 
    370                 375             

<210>   321
<211>   1137
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 310

<400>   321
gtgaaggtgg cattggtcca cgactggcta gttgatttcg cgggatcaga acgagttttg       60

tttgaacttg cgaagttgtt cccagatgcg ccaatctata cgtctgtcta tagcgaacgt      120

gctctcgcca atgtgtttcc gaaggaacgt gtgcgcacaa gttttttgca gaagataccg      180

ttgtcagtca agcgctatcg gtcattgttg ccgttcctac catttgcctt cgaaatgttc      240

gatttgacgg ggtatgatgt catcatctcg agttcacacg catgtgccaa aggcgtcgtt      300

gctggatcga atagtattca tatctgttat tgtcatacgc cgatgcgata cgcgtggagt      360

cactatcatc agtacctgag aggcgttcgc ggaacgctca aacgggctac cgtcggagcc      420

atcctttcat ggttgagaac atgggatttt atagctgctc aaagagttga tttcttcatt      480

gcgaattctt ctgaagtcca gaaacgaatc cggcattact atcgtagaga cgccgttgtg      540

atccatccgc ctatttcagc tcctgaaggc gaaaacggcg atccagagag agcagatttc      600

tatttgtatc tgggtcgttt agtcgagtat aagcgggtgg acttgcttgt ggacgctttt      660

cgccacctgc cgtctgcaag attgattgtg gcaggagatg gaccagagat gaatcgcctt      720

cgccgttcag ctccgctcaa cgtagagttc gcagggaagg tcacagaaga tgaaaaatgg      780

gatctgttga ggcgggcgaa ggctttgttg tttccagcac acgaggattt tggtatcgtg      840

attggggaag ccagagcagt tgggacgccc gtgatcggac ttgcacaagg gggcgttttg      900

gactacgcag gcgatcctgg tgtgctcccc tggattaaaa ggcaaaacct agaagatgtt      960

aaaatggccg tcgaccgatt tgaaagggaa tccttcaatt cggatgtcta cgagaagtac     1020

ctcattcaaa ccgaggatag ttttcgaaac gccgtcgcca ggcttgttga cgatttggtg     1080

gcgaacaaga aaggtgagtc gcgtgttggg cgtgcagcgg atgcgcgaga tcattga        1137


<210>   322
<211>   1137
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 310

<400>   322
gtgaaggtgg cattggtcca cgactggcta gttgatttcg cgggatcaga acgagttttg       60

tttgaacttg cgaagttgtt cccagatgcg ccaatctata cgtctgtcta tagcgaacgt      120

gctctcgcca atgtgtttcc gaaggaacgt gtgcgcacaa gttttttgca gaagataccg      180

ttgtcagtca agcgctatcg gtcattgttg ccgttcctac catttgcctt cgaaatgttc      240

gatttgacgg ggtatgatgt catcatctcg agttcacacg catgtgccaa aggcgtcgtt      300

gctggatcga atagtattca tatctgttat tgtcatacgc cgatgcgata cgcgtggagt      360

cactatcatc agtacctgag aggcgttcgc ggaacgctca aacgggctac cgtcggagcc      420

atcctttcat ggttgagaac atgggatttt atagctgctc aaagagttga tttcttcatt      480

gcgaattctt ctgaagtcca gaaacgaatc cggcattact atcgtagaga cgccgttgtg      540

atccatccgc ctatttcagc tcctgaaggc gaaaacggcg atccagagag agcagatttc      600

tatttgtatc tgggtcgttt agtcgagtat aagcgggtgg acttgcttgt ggacgctttt      660

cgccacctgc cgtctgcaag attgattgtg gcaggagatg gaccagagat gaatcgcctt      720

cgccgttcag ctccgctcaa cgtagagttc gcagggaagg tcacagaaga tgaaaaatgg      780

gatctgttga ggcgggcgaa ggctttgttg tttccagcac acgaggattt tggtatcgtg      840

attggggaag ccagagcagt tgggacgccc gtgatcggac ttgcacaagg gggcgttttg      900

gactacgcag gcgatcctgg tgtgctcccc tggattaaaa ggcaaaacct agacgatgtt      960

aaaatggccg tcgaccgatt tgaaagggaa tccttcaatt cggatattta cgagaagtac     1020

ctcattcaaa ccgaggatag ttttcgaaac gccgtcgcca ggcttgttga cgatttggtg     1080

gcgaacaaga aaggtgagtc gcgtgttggg cgtgcagcgg atgcgcgaga tcattga        1137


<210>   323
<211>   1137
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 310

<400>   323
gtgaaggtgg cattggtcca cgactggcta gttgatttcg cgggatcaga acgagttttg       60

tttgaacttg cgaagttgtt cccagatgcg ccaatctata cgtctgtcta tagcgaacgt      120

gctctcgcca atgtgtttcc gaaggaacgt gtgcgcacaa gttttttgca gaagataccg      180

ttgtcagtca agcgctatcg gtcattgttg ccgttcctac catttgcctt cgaaatgttc      240

gatttgacgg ggtatgatgt catcatctcg agttcacacg catgtgccaa aggcgtcgtt      300

gctggatcga atagtattca tatctgttat tgtcatacgc cgatgcgata cgcgtggagt      360

cactatcatc agtacctgag aggcgttcgc ggaacgctca aacgggctac cgtcggagcc      420

atcctttcat ggttgagaac atgggatttt atagctgctc aaagagttga tttcttcatt      480

gcgaattctt ctgaagtcaa taaacgaatc cggcattact atcgtagaga cgccgttgtg      540

atccatccgc ctatttcagc tcctgaaggc gaaaacggcg atccagagag agcagatttc      600

tatttgtatc tgggtcgttt agtcgagtat aagcgggtgg acttgcttgt ggacgctttt      660

cgccacctgc cgtctgcaag attgattgtg gcaggagatg gaccagagat gaatcgcctt      720

cgccgttcag ctccgctcaa cgtagagttc gcagggaagg tcacagaaga tgaaaaatgg      780

gatctgttga ggcgggcgaa ggctttgttg tttccagcac acgaggattt tggtatcgtg      840

attggggaag ccagagcagt tgggacgccc gtgatcggac ttgcacaagg gggcgttttg      900

gactacgcag gcgatcctgg tgtgctcccc tggattaaaa ggcaaaacct agacgatgtt      960

aaaatggccg tcgaccgatt tgaaagggaa tccttcaatt cggatgtcta cgagaagtac     1020

ctcattcaaa ccgaggatag ttttcgaaac gccgtcgcca ggcttgttga cgatttggtg     1080

gcgaacaaga aaggtgagtc gcgtgttggg cgtgcagcgg atgcgcgaga tcattga        1137


<210>   324
<211>   1137
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 310

<400>   324
gtgaaggtgg cattggtcca cgactggcta gttgatttcg cgggatcaga acgagttttg       60

tttgaacttg cgaagttgtt cccagatgcg ccaatctata cgtctgtcta tagcgaacgt      120

gctctcgcca atgtgtttcc gaaggaacgt gtgcgcacaa gttttttgca gaagataccg      180

ttgtcagtca agcgctatcg gtcattgttg ccgttcctac catttgcctt cgaaatgttc      240

gatttgacgg ggtatgatgt catcatctcg agttcacacg catgtgccaa aggcgtcgtt      300

gctggatcga atagtattca tatctgttat tgtcatacgc cgatgcgata cgcgtggagt      360

cactatcatc agtacctgag aggcattcgc ggaacgctca aacgggctac cgtcggagcc      420

atcctttcat ggttgagaac atgggatttt atagctgctc aaagagttga tttcttcatt      480

gcgaattctt ctgaagtcca gaaacgaatc cggcattact atcgtagaga cgccgttgtg      540

atccatccgc ctatttcagc tcctgaaggc gaaaacggcg atccagagag agcagatttc      600

tatttgtatc tgggtcgttt agtcgagtat aagcgggtgg acttgcttgt ggacgctttt      660

cgccacctgc cgtctgcaag attgattgtg gcaggagatg gaccagagat gaatcgcctt      720

cgccgttcag ctccgctcaa cgtagagttc gcagggaagg tcacagaaga tgaaaaatgg      780

gatctgttga ggcgggcgaa ggctttgttg tttccagcac acgaggattt tggtatcgtg      840

attggggaag ccagagcagt tgggacgccc gtgatcggac ttgcacaagg gggcgttttg      900

gactacgcag gcgatcctgg tgtgctcccc tggattaaaa ggcaaaacct agacgatgtt      960

aaaatggccg tcgaccgatt tgaaagggaa tccttcaatt cggatgtcta cgagaagtac     1020

ctcattcaaa ccgaggatag ttttcgaaac gccgtcgcca ggcttgttga cgatttggtg     1080

gcgaacaaga aaggtgagtc gcgtgttggg cgtgcagcgg atgcgcgaga tcattga        1137


<210>   325
<211>   1137
<212>   DNA
<213>   Artificial

<220>   
<223>   Substituion in SEQ ID NO 310

<400>   325
gtgaaggtgg cattggtcca cgactggcta gttgatttcg cgggatcaga acgagttttg       60

tttgaacttg cgaagttgtt cccagatgcg ccaatctata cgtctgtcta tagcgaacgt      120

gctctcgcca atgtgtttcc gaaggaacgt gtgcgcacaa gttttttgca gaagataccg      180

ttgtcagtca agcgctatcg gtcattgttg ccgttcctac catttgcctt cgaaatgttc      240

gatttgacgg ggtatgatgt catcatctcg agttcacacg catgtgccaa aggcgtcgtt      300

gctggatcga atagtattca tatctgttat tgtcatacgc cgatgcgata cgcgtggagt      360

cactatcatc agtacctgag aggcgttcgc ggaacgctca aaaaagctac cgtcggagcc      420

atcctttcat ggttgagaac atgggatttt atagctgctc aaagagttga tttcttcatt      480

gcgaattctt ctgaagtcca gaaacgaatc cggcattact atcgtagaga cgccgttgtg      540

atccatccgc ctatttcagc tcctgaaggc gaaaacggcg atccagagag agcagatttc      600

tatttgtatc tgggtcgttt agtcgagtat aagcgggtgg acttgcttgt ggacgctttt      660

cgccacctgc cgtctgcaag attgattgtg gcaggagatg gaccagagat gaatcgcctt      720

cgccgttcag ctccgctcaa cgtagagttc gcagggaagg tcacagaaga tgaaaaatgg      780

gatctgttga ggcgggcgaa ggctttgttg tttccagcac acgaggattt tggtatcgtg      840

attggggaag ccagagcagt tgggacgccc gtgatcggac ttgcacaagg gggcgttttg      900

gactacgcag gcgatcctgg tgtgctcccc tggattaaaa ggcaaaacct agacgatgtt      960

aaaatggccg tcgaccgatt tgaaagggaa tccttcaatt cggatgtcta cgagaagtac     1020

ctcattcaaa ccgaggatag ttttcgaaac gccgtcgcca ggcttgttga cgatttggtg     1080

gcgaacaaga aaggtgagtc gcgtgttggg cgtgcagcgg atgcgcgaga tcattga        1137


