                         SEQUENCE LISTING

<110>  IRM
       Geierstanger, Bernhard
 
<120>  BIOSYNTHETICALLY GENERATED PYRROLINE-CARBOXY-LYSINE AND SITE 
       SPECIFIC PROTEIN MODIFICATIONS VIA CHEMICAL DERIVATIZATION OF 
       PYRROLINE-CARBOXY-LYSINE AND PYRROLYSINE RESIDUES

<130>  PAT053160-WO

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  1365
<212>  DNA
<213>  Methanosarcina mazeii

<400>  1
atggataaaa aaccactaaa cactctgata tctgcaaccg ggctctggat gtccaggacc       60

ggaacaattc ataaaataaa acaccacgaa gtctctcgaa gcaaaatcta tattgaaatg      120

gcatgcggag accaccttgt tgtaaacaac tccaggagca gcaggactgc aagagcgctc      180

aggcaccaca aatacaggaa gacctgcaaa cgctgcaggg tttcggatga ggatctcaat      240

aagttcctca caaaggcaaa cgaagaccag acaagcgtaa aagtcaaggt cgtttctgcc      300

cctaccagaa cgaaaaaggc aatgccaaaa tccgttgcga gagccccgaa acctcttgag      360

aatacagaag cggcacaggc tcaaccttct ggatctaaat tttcacctgc gataccggtt      420

tccacccaag agtcagtttc tgtcccggca tctgtttcaa catcaatatc aagcatttct      480

acaggagcaa ctgcatccgc actggtaaaa gggaatacga accccattac atccatgtct      540

gcccctgttc aggcaagtgc ccccgcactt acgaagagcc agactgacag gcttgaagtc      600

ctgttaaacc caaaagatga gatttccctg aattccggca agcctttcag ggagcttgag      660

tccgaattgc tctctcgcag aaaaaaagac ctgcagcaga tctacgcgga agaaagggag      720

aattatctgg ggaaactcga gcgtgaaatt accaggttct ttgtggacag gggttttctg      780

gaaataaaat ccccgatcct gatccctctt gagtatatcg aaaggatggg cattgataat      840

gataccgaac tttcaaaaca gatcttcagg gttgacaaga acttctgcct gagacccatg      900

cttgctccaa acctttacaa ctacctgcgc aagcttgaca gggccctgcc tgatccaata      960

aaaatttttg aaataggccc atgctacaga aaagagtccg acggcaaaga acacctcgaa     1020

gagtttacca tgctgaactt ctgccagatg ggatcgggat gcacacggga aaatcttgaa     1080

agcataatta cggacttcct gaaccacctg ggaattgatt tcaagatcgt aggcgattcc     1140

tgcatggtct atggggatac ccttgatgta atgcacggag acctggaact ttcctctgca     1200

gtagtcggac ccataccgct tgaccgggaa tggggtattg ataaaccctg gataggggca     1260

ggtttcgggc tcgaacgcct tctaaaggtt aaacacgact ttaaaaatat caagagagct     1320

gcaaggtccg agtcttacta taacgggatt tctaccaacc tgtaa                     1365


<210>  2
<211>  1050
<212>  DNA
<213>  Methanosarcina mazeii

<400>  2
atgatccaga aaatggcaac cgaagaactt gacaggttcg gggagaaaat tattgaaggt       60

tttaaattgt ctgatgatga cctcagggct cttctttctc ttgaattcga agaagagctg      120

gaaaagcttt actatgtagc tagaaaggtc agaaactatt atttcggcaa cagggtgttt      180

cttaactgtt ttatttattt ctcaacttat tgtaaaaacc agtgctcttt ttgctactat      240

aactgtaaaa acgaaattaa ccgctaccgc ctgaccggtg aagaggttaa agagatgtgc      300

aaagccctga aaggtgcagg ctttcacatg atcgacctga caatgggaga ggatccctat      360

tactatgatg accctgaccg cttcgttgaa cttgtcagga cagtaaaaga agaactcggg      420

cttccaataa tgatttctcc gggagttatg gatgacagca ccctcctgaa agccagggaa      480

gaaggagcaa atttctttgc cctttatcag gagacttatg accgcgaact ttatggaaag      540

ctaagggtag gtcagtcctt cgaaggaagg tttaatgccc gcaggtttgc aaaagaacag      600

gggtactgta tagaagacgg cattcttacc ggcgtaggaa atgatatcga atcaactctt      660

atatccctga aggggatgaa agcaaacaat cctgatatgg taagggtaat gacttttctg      720

cctcaggaag gaactccgct tgaaggtttc agcgatagtt caaagctttc ggagctgaaa      780

atcatagcga ttctcaggct catgtttcct gaatgcctga taccggcttc tcttgacctt      840

gaaggcatag acggcatggt gcaccgttta aatgccggag caaatattgt aacctccatc      900

ctcccagatt cacgcctgga aggggttgcc aattacgacc gcggcatgga agagagggac      960

agggacgtta caagcgttgt caaaaggctg aaggttatgg gaatggaacc tgcgccgcag     1020

gctgagtttg agagagtcct ggggtgctaa                                      1050


<210>  3
<211>  1116
<212>  DNA
<213>  Methanosarcina mazeii

<400>  3
atgagagagt cctggggtgc tagcctgaaa acaatatgcc ttataggcgg gaagctgcag       60

ggcttcgagg ctgcatacct atctaagaaa gccggaatga aagtgcttgt aatagacaaa      120

aacccgcagg cgcttataag gaattatgcg gatgagttcc agtgttttaa cataacggaa      180

gagccggaaa aactcgtcgc gatatcaaaa aatgttgatg ccatactgcc ggtaaatgaa      240

aaccttgaat gtatagaatt tctgaattct ataaaagaaa aattctcctg cccggtactt      300

ttcgattttg aagcttacag gatcagcagg gataagagaa aatcaaaaga atacttcgca      360

tccataggaa ccccgacccc tcaggacaaa ccgtcggaac caccttattt tgtaaagcct      420

ccctgcgaaa gcagcagtgt gggagcgaga ataatccatg acaggaaaga gcttaaagag      480

cttgagcccg ggatgctcat agaagaatac gttgaagggg aagtggtctc acttgaggtc      540

ataggggatg gaaataattt tgctgtggta aaggaaaccc ttgtacatat cgatgacacc      600

tatgactgcc atatggtgac ccctctccct ctagaccctt ccttcaggga actatcctac      660

tcccttgcag caaacctgcc cttaaaagga attatggacg tggaagcgat ttccggcccc      720

ctggggttaa aagttattga gatagatgcc cgtttcccga gccagactcc gactgcggtc      780

tattattctt ccgggatcaa cctcatagaa ctcctgttcc gggcttttaa tggaggcata      840

gaagagatca aaactctccc tgaagacagg tactgcattt acgaacatct catgcttgca      900

gaaaatggag tacttatccc tgtgggagaa caggtcctgt ccatgggaaa tgattacggc      960

aattattatg aagaacctgg aatagagatt ttcctgtgca aaggagagaa ccctgtattc     1020

accctggttt tctggggcag agacagggaa gaagctgaag ctagaaaaaa caaagggctt     1080

tcgattctaa aaagccgttt cggagctgct gcataa                               1116


<210>  4
<211>  795
<212>  DNA
<213>  Methanosarcina mazeii

<400>  4
atggcacttt taaccccaga agacctggaa aatattaaca aacagcttca agaagctgat       60

tctactgtcc gcagagttac agggcttgat ataaaaggta tctgtaaaga tttctacggc      120

acaactccat gctgtgaaaa agtaggtatc gtgcctgtga cctcagggaa cgggatcata      180

gggagctttt ccgaatccct gaatgcaatt gccgggtatt tcgggtttga cagttttatt      240

actgatatgc ctgacgtcag cggatattat gaggcagtaa agaacggagc ccggatcata      300

cttatggcag atgataatac cttccttgcc cacaacctga aaaatggaaa aatcgccaat      360

aaccagccgt gtacaggcat aatttatgct gaaatagctt caagatacct gaaagccgat      420

tccaaagaag tgcttgccgt gggtcttggg aaggttggat ttccgggagc agcccatctc      480

gtacagaaag gcttcaaggt ttacggatat gatgctgaca gaacccttct agaaaaaagc      540

gtttccagcc tcggaattat acctttcaat cccgtcagcc ccgaaggcga caggcaaagg      600

aagttttcca ttattttcga agcaaccccc tgtgcagaca cgattccgga atccgtaatt      660

tcggaaaact gtgtgatttc tacccctggg ataccctgtg caatctcaaa ggagctgcaa      720

aaaaagtgtg gagttgaact tgtaatggaa ccactgggga taggtacagc atcaatgctg      780

tattctgtac tctaa                                                       795


<210>  5
<211>  72
<212>  DNA
<213>  Methanosarcina mazeii

<400>  5
ggaaacctga tcatgtagat cgaatggact ctaaatccgt tcagccgggt tagattcccg       60

gggtttccgc ca                                                           72


<210>  6
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Lys Thr Phe Ile Leu Leu Leu Trp Val Leu Leu Leu Trp Val Ile 
1               5                   10                  15      


Phe Leu Leu Pro Gly Ala Thr Ala Gln Pro Glu Arg Asp Cys Arg Val 
            20                  25                  30          


Ser Ser Phe Arg Val Lys Glu Asn Phe Asp Lys Ala Arg Phe Ser Gly 
        35                  40                  45              


Thr Trp Tyr Ala Met Ala Lys Lys Asp Pro Glu Gly Leu Phe Leu Gln 
    50                  55                  60                  


Asp Asn Ile Val Ala Glu Phe Ser Val Asp Glu Thr Gly Gln Met Ser 
65                  70                  75                  80  


Ala Thr Ala Lys Gly Arg Val Arg Leu Leu Asn Asn Trp Asp Val Cys 
                85                  90                  95      


Ala Asp Met Val Gly Thr Phe Thr Asp Thr Glu Asp Pro Ala Lys Phe 
            100                 105                 110         


Lys Met Lys Tyr Trp Gly Val Ala Ser Phe Leu Gln Lys Gly Asn Asp 
        115                 120                 125             


Asp His Trp Ile Val Asp Thr Asp Tyr Asp Thr Tyr Ala Val Gln Tyr 
    130                 135                 140                 


Ser Cys Arg Leu Leu Asn Leu Asp Gly Thr Cys Ala Asp Ser Tyr Ser 
145                 150                 155                 160 


Phe Val Phe Ser Arg Asp Pro Asn Gly Leu Pro Pro Glu Ala Gln Lys 
                165                 170                 175     


Ile Val Arg Gln Arg Gln Glu Glu Leu Cys Leu Ala Arg Gln Tyr Arg 
            180                 185                 190         


Leu Ile Val His Asn Gly Tyr Cys Asp Gly Arg Ser Glu Arg Asn Leu 
        195                 200                 205             


Leu Asp Tyr Lys Asp Asp Asp Asp Lys His His His His His His 
    210                 215                 220             


<210>  7
<211>  672
<212>  DNA
<213>  Homo sapiens

<400>  7
atgaaaacat tcatactcct gctctgggta ctgctgctct gggttatctt cctgcttccc       60

ggtgccactg ctcagcctga gcgcgactgc cgagtgagca gcttccgagt caaggagaac      120

ttcgacaagg ctcgcttctc tgggacctgg tacgccatgg ccaagaagga ccccgagggc      180

ctctttctgc aggacaacat cgtcgcggag ttctccgtgg acgagaccgg ccagatgagc      240

gccacagcca agggccgagt ccgtcttttg aataactggg acgtgtgcgc agacatggtg      300

ggcaccttca cagacaccga ggaccctgcc aagttcaaga tgaagtactg gggcgtagcc      360

tcctttctcc agaaaggaaa tgatgaccac tggatcgtcg acacagacta cgacacgtat      420

gccgtgcagt actcctgccg cctcctgaac ctcgatggca cctgtgctga cagctactcc      480

ttcgtgtttt cccgggaccc caacggcctg cccccagaag cgcagaagat tgtaaggcag      540

cggcaggagg agctgtgcct ggccaggcag tacaggctga tcgtccacaa cggttactgc      600

gatggcagat cagaaagaaa ccttttggac tataaagacg atgacgataa gcatcaccat      660

caccatcact aa                                                          672


<210>  8
<211>  672
<212>  DNA
<213>  Homo sapiens

<400>  8
atgaaaacat tcatactcct gctctgggta ctgctgctct gggttatctt cctgcttccc       60

ggtgccactg ctcagcctga gcgcgactgc cgagtgagca gcttccgagt caaggagaac      120

ttcgacaagg ctcgcttctc tgggacctgg taggccatgg ccaagaagga ccccgagggc      180

ctctttctgc aggacaacat cgtcgcggag ttctccgtgg acgagaccgg ccagatgagc      240

gccacagcca agggccgagt ccgtcttttg aataactggg acgtgtgcgc agacatggtg      300

ggcaccttca cagacaccga ggaccctgcc aagttcaaga tgaagtactg gggcgtagcc      360

tcctttctcc agaaaggaaa tgatgaccac tggatcgtcg acacagacta cgacacgtat      420

gccgtgcagt actcctgccg cctcctgaac ctcgatggca cctgtgctga cagctactcc      480

ttcgtgtttt cccgggaccc caacggcctg cccccagaag cgcagaagat tgtaaggcag      540

cggcaggagg agctgtgcct ggccaggcag tacaggctga tcgtccacaa cggttactgc      600

gatggcagat cagaaagaaa ccttttggac tataaagacg atgacgataa gcatcaccat      660

caccatcact aa                                                          672


<210>  9
<211>  672
<212>  DNA
<213>  Homo sapiens

<400>  9
atgaaaacat tcatactcct gctctgggta ctgctgctct gggttatctt cctgcttccc       60

ggtgccactg ctcagcctga gcgcgactgc cgagtgagca gcttccgagt caaggagaac      120

ttcgacaagg ctcgcttctc tgggacctgg tacgccatgg ccaagaagga ccccgagggc      180

ctctagctgc aggacaacat cgtcgcggag ttctccgtgg acgagaccgg ccagatgagc      240

gccacagcca agggccgagt ccgtcttttg aataactggg acgtgtgcgc agacatggtg      300

ggcaccttca cagacaccga ggaccctgcc aagttcaaga tgaagtactg gggcgtagcc      360

tcctttctcc agaaaggaaa tgatgaccac tggatcgtcg acacagacta cgacacgtat      420

gccgtgcagt actcctgccg cctcctgaac ctcgatggca cctgtgctga cagctactcc      480

ttcgtgtttt cccgggaccc caacggcctg cccccagaag cgcagaagat tgtaaggcag      540

cggcaggagg agctgtgcct ggccaggcag tacaggctga tcgtccacaa cggttactgc      600

gatggcagat cagaaagaaa ccttttggac tataaagacg atgacgataa gcatcaccat      660

caccatcact aa                                                          672


<210>  10
<211>  672
<212>  DNA
<213>  Homo sapiens

<400>  10
atgaaaacat tcatactcct gctctgggta ctgctgctct gggttatctt cctgcttccc       60

ggtgccactg ctcagcctga gcgcgactgc cgagtgagca gcttccgagt caaggagaac      120

ttcgacaagg ctcgcttctc tgggacctgg tacgccatgg ccaagaagga ccccgagggc      180

ctctttctgc aggacaacat cgtcgcggag ttctccgtgg acgagaccgg ccagatgagc      240

gccacagcca agggccgagt ccgtcttttg aataactagg acgtgtgcgc agacatggtg      300

ggcaccttca cagacaccga ggaccctgcc aagttcaaga tgaagtactg gggcgtagcc      360

tcctttctcc agaaaggaaa tgatgaccac tggatcgtcg acacagacta cgacacgtat      420

gccgtgcagt actcctgccg cctcctgaac ctcgatggca cctgtgctga cagctactcc      480

ttcgtgtttt cccgggaccc caacggcctg cccccagaag cgcagaagat tgtaaggcag      540

cggcaggagg agctgtgcct ggccaggcag tacaggctga tcgtccacaa cggttactgc      600

gatggcagat cagaaagaaa ccttttggac tataaagacg atgacgataa gcatcaccat      660

caccatcact aa                                                          672


<210>  11
<211>  672
<212>  DNA
<213>  Homo sapiens

<400>  11
atgaaaacat tcatactcct gctctgggta ctgctgctct gggttatctt cctgcttccc       60

ggtgccactg ctcagcctga gcgcgactgc cgagtgagca gcttccgagt caaggagaac      120

ttcgacaagg ctcgcttctc tgggacctgg tacgccatgg ccaagaagga ccccgagggc      180

ctctttctgc aggacaacat cgtcgcggag ttctccgtgg acgagaccgg ccagatgagc      240

gccacagcca agggccgagt ccgtcttttg aataactggg acgtgtgcgc agacatggtg      300

ggcaccttca cagacaccga ggaccctgcc aagttcaaga tgaagtagtg gggcgtagcc      360

tcctttctcc agaaaggaaa tgatgaccac tggatcgtcg acacagacta cgacacgtat      420

gccgtgcagt actcctgccg cctcctgaac ctcgatggca cctgtgctga cagctactcc      480

ttcgtgtttt cccgggaccc caacggcctg cccccagaag cgcagaagat tgtaaggcag      540

cggcaggagg agctgtgcct ggccaggcag tacaggctga tcgtccacaa cggttactgc      600

gatggcagat cagaaagaaa ccttttggac tataaagacg atgacgataa gcatcaccat      660

caccatcact aa                                                          672


<210>  12
<211>  672
<212>  DNA
<213>  Homo sapiens

<400>  12
atgaaaacat tcatactcct gctctgggta ctgctgctct gggttatctt cctgcttccc       60

ggtgccactg ctcagcctga gcgcgactgc cgagtgagca gcttccgagt caaggagaac      120

ttcgacaagg ctcgcttctc tgggacctgg tacgccatgg ccaagaagga ccccgagggc      180

ctctttctgc aggacaacat cgtcgcggag ttctccgtgg acgagaccgg ccagatgagc      240

gccacagcca agggccgagt ccgtcttttg aataactggg acgtgtgcgc agacatggtg      300

ggcaccttca cagacaccga ggaccctgcc aagttcaaga tgaagtacta gggcgtagcc      360

tcctttctcc agaaaggaaa tgatgaccac tggatcgtcg acacagacta cgacacgtat      420

gccgtgcagt actcctgccg cctcctgaac ctcgatggca cctgtgctga cagctactcc      480

ttcgtgtttt cccgggaccc caacggcctg cccccagaag cgcagaagat tgtaaggcag      540

cggcaggagg agctgtgcct ggccaggcag tacaggctga tcgtccacaa cggttactgc      600

gatggcagat cagaaagaaa ccttttggac tataaagacg atgacgataa gcatcaccat      660

caccatcact aa                                                          672


<210>  13
<211>  672
<212>  DNA
<213>  Homo sapiens

<400>  13
atgaaaacat tcatactcct gctctgggta ctgctgctct gggttatctt cctgcttccc       60

ggtgccactg ctcagcctga gcgcgactgc cgagtgagca gcttccgagt caaggagaac      120

ttcgacaagg ctcgcttctc tgggacctgg tacgccatgg ccaagaagga ccccgagggc      180

ctctttctgc aggacaacat cgtcgcggag ttctccgtgg acgagaccgg ccagatgagc      240

gccacagcca agggccgagt ccgtcttttg aataactggg acgtgtgcgc agacatggtg      300

ggcaccttca cagacaccga ggaccctgcc aagttcaaga tgaagtactg gggcgtagcc      360

tcctagctcc agaaaggaaa tgatgaccac tggatcgtcg acacagacta cgacacgtat      420

gccgtgcagt actcctgccg cctcctgaac ctcgatggca cctgtgctga cagctactcc      480

ttcgtgtttt cccgggaccc caacggcctg cccccagaag cgcagaagat tgtaaggcag      540

cggcaggagg agctgtgcct ggccaggcag tacaggctga tcgtccacaa cggttactgc      600

gatggcagat cagaaagaaa ccttttggac tataaagacg atgacgataa gcatcaccat      660

caccatcact aa                                                          672


<210>  14
<211>  672
<212>  DNA
<213>  Homo sapiens

<400>  14
atgaaaacat tcatactcct gctctgggta ctgctgctct gggttatctt cctgcttccc       60

ggtgccactg ctcagcctga gcgcgactgc cgagtgagca gcttccgagt caaggagaac      120

ttcgacaagg ctcgcttctc tgggacctgg tacgccatgg ccaagaagga ccccgagggc      180

ctctttctgc aggacaacat cgtcgcggag ttctccgtgg acgagaccgg ccagatgagc      240

gccacagcca agggccgagt ccgtcttttg aataactggg acgtgtgcgc agacatggtg      300

ggcaccttca cagacaccga ggaccctgcc aagttcaaga tgaagtactg gggcgtagcc      360

tcctttctcc agaaaggaaa tgatgaccac tggatcgtcg acacagacta cgacacgtag      420

gccgtgcagt actcctgccg cctcctgaac ctcgatggca cctgtgctga cagctactcc      480

ttcgtgtttt cccgggaccc caacggcctg cccccagaag cgcagaagat tgtaaggcag      540

cggcaggagg agctgtgcct ggccaggcag tacaggctga tcgtccacaa cggttactgc      600

gatggcagat cagaaagaaa ccttttggac tataaagacg atgacgataa gcatcaccat      660

caccatcact aa                                                          672


<210>  15
<211>  672
<212>  DNA
<213>  Homo sapiens

<400>  15
atgaaaacat tcatactcct gctctgggta ctgctgctct gggttatctt cctgcttccc       60

ggtgccactg ctcagcctga gcgcgactgc cgagtgagca gcttccgagt caaggagaac      120

ttcgacaagg ctcgcttctc tgggacctgg tacgccatgg ccaagaagga ccccgagggc      180

ctctttctgc aggacaacat cgtcgcggag ttctccgtgg acgagaccgg ccagatgagc      240

gccacagcca agggccgagt ccgtcttttg aataactggg acgtgtgcgc agacatggtg      300

ggcaccttca cagacaccga ggaccctgcc aagttcaaga tgaagtactg gggcgtagcc      360

tcctttctcc agaaaggaaa tgatgaccac tggatcgtcg acacagacta cgacacgtat      420

gccgtgcagt actcctgccg cctcctgaac ctcgatggca cctgtgctga cagctactcc      480

ttcgtgtttt cccgggaccc caacggcctg cccccagaag cgcagaagat tgtaaggcag      540

cggcaggagg agctgtgcct ggccaggcag tagaggctga tcgtccacaa cggttactgc      600

gatggcagat cagaaagaaa ccttttggac tataaagacg atgacgataa gcatcaccat      660

caccatcact aa                                                          672


<210>  16
<211>  672
<212>  DNA
<213>  Homo sapiens

<400>  16
atgaaaacat tcatactcct gctctgggta ctgctgctct gggttatctt cctgcttccc       60

ggtgccactg ctcagcctga gcgcgactgc cgagtgagca gcttccgagt caaggagaac      120

ttcgacaagg ctcgcttctc tgggacctgg tacgccatgg ccaagaagga ccccgagggc      180

ctctttctgc aggacaacat cgtcgcggag ttctccgtgg acgagaccgg ccagatgagc      240

gccacagcca agggccgagt ccgtcttttg aataactggg acgtgtgcgc agacatggtg      300

ggcaccttca cagacaccga ggaccctgcc aagttcaaga tgaagtactg gggcgtagcc      360

tcctttctcc agaaaggaaa tgatgaccac tggatcgtcg acacagacta cgacacgtat      420

gccgtgcagt actcctgccg cctcctgaac ctcgatggca cctgtgctga cagctactcc      480

ttcgtgtttt cccgggaccc caacggcctg cccccagaag cgcagaagat tgtaaggcag      540

cggcaggagg agctgtgcct ggccaggcag tacaggctga tcgtccacaa cggttagtgc      600

gatggcagat cagaaagaaa ccttttggac tataaagacg atgacgataa gcatcaccat      660

caccatcact aa                                                          672


<210>  17
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is a PCL residue

<400>  17

Tyr Trp Gly Val Ala Ser Xaa Leu Gln Lys 
1               5                   10  


<210>  18
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is Cyc residue

<400>  18

Lys Asp Pro Glu Gly Leu Xaa Leu Gln Asp Asn Ile Val Ala Glu Phe 
1               5                   10                  15      


Ser Val Asp Glu Thr Gly Gln Met Ser Ala Thr Ala Lys 
            20                  25                  


<210>  19
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  19

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Ile Thr Thr Gly Cys Ala Glu His 
            20                  25                  30          


Cys Ser Leu Asn Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Ala Trp Lys Arg Met Glu Val Gly Gln Gln Ala Val Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gln Ala Leu 
65                  70                  75                  80  


Leu Val Asn Ser Ser Gln Pro Trp Glu Pro Leu Gln Leu His Val Asp 
                85                  90                  95      


Lys Ala Val Ser Gly Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Ala Ile Ser Pro Pro Asp Ala Ala Ser Ala Ala 
        115                 120                 125             


Pro Leu Arg Thr Ile Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala 
145                 150                 155                 160 


Cys Arg Thr Gly Asp Arg 
                165     


<210>  20
<211>  166
<212>  PRT
<213>  mouse

<400>  20

Ala Pro Pro Arg Leu Ile Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 
1               5                   10                  15      


Leu Glu Ala Lys Glu Ala Glu Asn Val Thr Met Gly Cys Ala Glu Gly 
            20                  25                  30          


Pro Arg Leu Ser Glu Asn Ile Thr Val Pro Asp Thr Lys Val Asn Phe 
        35                  40                  45              


Tyr Ala Trp Lys Arg Met Glu Val Glu Glu Gln Ala Ile Glu Val Trp 
    50                  55                  60                  


Gln Gly Leu Ser Leu Leu Ser Glu Ala Ile Leu Gln Ala Gln Ala Leu 
65                  70                  75                  80  


Leu Ala Asn Ser Ser Gln Pro Pro Glu Thr Leu Gln Leu His Ile Asp 
                85                  90                  95      


Lys Ala Val Ser Gly Leu Arg Ser Leu Thr Ser Leu Leu Arg Val Leu 
            100                 105                 110         


Gly Ala Gln Lys Glu Leu Met Ser Pro Pro Asp Thr Thr Pro Pro Ala 
        115                 120                 125             


Pro Leu Arg Thr Leu Thr Val Asp Thr Phe Cys Lys Leu Phe Arg Val 
    130                 135                 140                 


Tyr Ala Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Val 
145                 150                 155                 160 


Cys Arg Arg Gly Asp Arg 
                165     


<210>  21
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  21

Met Gly Asp Ser Lys Ile His His His His His His Glu Asn Leu Tyr 
1               5                   10                  15      


Phe Gln Gly 
            


<210>  22
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Gly Ser Asp Lys Ile His His His His His His Glu Asn Leu Tyr 
1               5                   10                  15      


Phe Gln Gly Ser Leu Leu Val Asn Pro Glu Gly Pro Thr Leu Met Arg 
            20                  25                  30          


Leu Asn Ser Val Gln Ser Ser Glu Arg Pro Leu Phe Leu Val His Pro 
        35                  40                  45              


Ile Glu Gly Ser Thr Thr Val Phe His Ser Leu Ala Ser Arg Leu Ser 
    50                  55                  60                  


Ile Pro Thr Tyr Gly Leu Gln Cys Thr Arg Ala Ala Pro Leu Asp Ser 
65                  70                  75                  80  


Ile His Ser Leu Ala Ala Tyr Tyr Ile Asp Cys Ile Arg Gln Val Gln 
                85                  90                  95      


Pro Glu Gly Pro Tyr Arg Val Ala Gly Tyr Ser Tyr Gly Ala Cys Val 
            100                 105                 110         


Ala Phe Glu Met Cys Ser Gln Leu Gln Ala Gln Gln Ser Pro Ala Pro 
        115                 120                 125             


Thr His Asn Ser Leu Phe Leu Phe Asp Gly Ser Pro Thr Tyr Val Leu 
    130                 135                 140                 


Ala Tyr Thr Gln Ser Tyr Arg Ala Lys Leu Thr Pro Gly Ser Glu Ala 
145                 150                 155                 160 


Glu Ala Glu Thr Glu Ala Ile Cys Phe Phe Val Gln Gln Phe Thr Asp 
                165                 170                 175     


Met Glu His Asn Arg Val Leu Glu Ala Leu Leu Pro Leu Lys Gly Leu 
            180                 185                 190         


Glu Glu Arg Val Ala Ala Ala Val Asp Leu Ile Ile Lys Ser His Gln 
        195                 200                 205             


Gly Leu Asp Arg Gln Glu Leu Ser Phe Ala Ala Arg Ser Phe Tyr Tyr 
    210                 215                 220                 


Lys Leu Arg Ala Ala Glu Gln Tyr Thr Pro Lys Ala Lys Tyr His Gly 
225                 230                 235                 240 


Asn Val Met Leu Leu Arg Ala Lys Thr Gly Gly Ala Tyr Gly Glu Asp 
                245                 250                 255     


Leu Gly Ala Asp Tyr Asn Leu Ser Gln Val Cys Asp Gly Lys Val Ser 
            260                 265                 270         


Val His Val Ile Glu Gly Asp His Arg Thr Leu Leu Glu Gly Ser Gly 
        275                 280                 285             


Leu Glu Ser Ile Ile Ser Ile Ile His Ser Ser Leu Ala 
    290                 295                 300     


<210>  23
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  23

Met Gly Ser Ser His His His His His His Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro 
        


<210>  24
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Gly Ser Ser His His His His His His Leu Glu Val Leu Phe Gln 
1               5                   10                  15      


Gly Pro Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr 
            20                  25                  30          


Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu 
        35                  40                  45              


Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe 
    50                  55                  60                  


Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly 
65                  70                  75                  80  


Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro 
                85                  90                  95      


Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His 
            100                 105                 110         


Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
        115                 120                 125 


<210>  25
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Gly Ser Ser His His His His His His Ser Ser Gly Glu Asn Leu 
1               5                   10                  15      


Tyr Phe Gln Gly Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Val Arg 
            20                  25                  30          


Gln Arg Tyr Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu 
        35                  40                  45              


Glu Ile Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro 
    50                  55                  60                  


Glu Ser Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile 
65                  70                  75                  80  


Leu Gly Val Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala 
                85                  90                  95      


Leu Tyr Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu 
            100                 105                 110         


Leu Leu Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly 
        115                 120                 125             


Leu Pro Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala 
    130                 135                 140                 


Pro Arg Gly Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala 
145                 150                 155                 160 


Leu Pro Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly 
                165                 170                 175     


Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro 
            180                 185                 190         


Ser Tyr Ala Ser 
        195     


<210>  26
<211>  173
<212>  PRT
<213>  mouse

<400>  26

Met Arg Gly Ser His His His His His His Gly Ser Gly Ile Glu Gly 
1               5                   10                  15      


Arg Leu Arg Ser Ser Ser Gln Asn Ser Ser Asp Lys Pro Val Ala His 
            20                  25                  30          


Val Val Ala Asn His Gln Val Glu Glu Gln Leu Trp Leu Ser Gln Arg 
        35                  40                  45              


Ala Asn Ala Leu Leu Ala Asn Gly Met Asp Leu Lys Asp Asn Gln Leu 
    50                  55                  60                  


Val Val Pro Ala Asp Gly Leu Tyr Leu Val Tyr Ser Gln Val Leu Phe 
65                  70                  75                  80  


Lys Gly Gln Gly Cys Pro Asp Tyr Val Leu Leu Thr His Thr Val Ser 
                85                  90                  95      


Arg Phe Ala Ile Ser Tyr Gln Glu Lys Val Asn Leu Leu Ser Ala Val 
            100                 105                 110         


Lys Ser Pro Cys Pro Lys Asp Thr Pro Glu Gly Ala Glu Leu Lys Pro 
        115                 120                 125             


Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly 
    130                 135                 140                 


Asp Gln Leu Ser Ala Glu Val Asn Leu Pro Lys Tyr Leu Asp Phe Ala 
145                 150                 155                 160 


Glu Ala Ser Gly Gln Val Tyr Phe Gly Val Ile Ala Leu 
                165                 170             


<210>  27
<211>  62
<212>  PRT
<213>  mouse

<400>  27

Met Asn Ser Tyr Pro Gly Cys Pro Ser Ser Tyr Asp Gly Tyr Cys Leu 
1               5                   10                  15      


Asn Gly Gly Val Cys Met His Ile Glu Ser Leu Asp Ser Tyr Thr Cys 
            20                  25                  30          


Asn Cys Val Ile Gly Tyr Ser Gly Asp Arg Cys Gln Thr Arg Asp Leu 
        35                  40                  45              


Arg Trp Trp Glu Leu Arg Leu Glu His His His His His His 
    50                  55                  60          


<210>  28
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  cyclohexyl-alanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  cyclohexyl-alanine

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  D-alanine

<400>  28

Gly Xaa Lys Xaa Val Ala Ala Trp Thr Leu Lys Ala Xaa Gly 
1               5                   10                  


<210>  29
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  D-alanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  cyclohexyl-alanine

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  cyclohexyl-alanine

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  D-alanine

<400>  29

Ala Gly Ser Arg Ser Gly Xaa Lys Xaa Val Ala Ala Trp Thr Leu Lys 
1               5                   10                  15      


Ala Xaa Gly 
            


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  phosphothioate backbone

<400>  30
tccatgacgt tcctgacgtt                                                   20


<210>  31
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  phosphothioate backbone

<400>  31
tcgtcgtttt cggcgcgcgc cg                                                22


<210>  32
<211>  22
<212>  PRT
<213>  mouse


<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  PCL

<400>  32

Met Asn Ser Tyr Pro Gly Cys Pro Ser Ser Xaa Asp Gly Tyr Cys Leu 
1               5                   10                  15      


Asn Gly Gly Val Cys Met 
            20          


<210>  33
<211>  22
<212>  PRT
<213>  mouse


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  pyrrolysine

<400>  33

Met Asn Ser Tyr Pro Gly Cys Pro Ser Ser Xaa Asp Gly Tyr Cys Leu 
1               5                   10                  15      


Asn Gly Gly Val Cys Met 
            20          


<210>  34
<211>  14
<212>  PRT
<213>  mouse


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  pyrrolysine

<400>  34

Asn His Xaa Val Glu Glu Gln Leu Glu Trp Leu Ser Gln Arg 
1               5                   10                  


<210>  35
<211>  14
<212>  PRT
<213>  mouse


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  PCL

<400>  35

Asn His Xaa Val Glu Glu Gln Leu Glu Trp Leu Ser Gln Arg 
1               5                   10                  


