                         SEQUENCE LISTING

<110>  Khan, Shaharyar
 
<120>  TRANSDUCIBLE POLYPEPTIDES FOR MODIFYING METABOLISM

<130>  GNC 0003 CIP (4)

<150>  US 60/513,983
<151>  2003-10-24

<150>  US 10/972,963
<151>  2004-10-25

<150>  US 60/568,436
<151>  2004-05-05

<150>  US 11/389,432
<151>  2007-03-24

<150>  US 11/930,892
<151>  2007-10-31

<150>  US 11/923,674
<151>  2007-10-31

<160>  19    

<170>  PatentIn version 3.3

<210>  1
<211>  11
<212>  PRT
<213>  Human immunodeficiency virus

<400>  1

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  2
<211>  9
<212>  PRT
<213>  Human immunodeficiency virus

<400>  2

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  3
<211>  10
<212>  DNA
<213>  Artificial sequence

<220>
<223>  SOX9 DNA binding domain

<400>  3
agaacaatgg                                                            10


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic protein transduction domain

<400>  4

Arg Arg Arg Arg Arg Arg Arg 
1               5           


<210>  5
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein transduction domain

<400>  5

Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg 
1               5                   10          


<210>  6
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein transduction domain

<400>  6

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  7
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein transduction domain

<400>  7

Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala Leu Ala Lys His 
1               5                   10                  15      


Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Cys Glu Ala 
            20                  25                  


<210>  8
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein transduction domain

<400>  8

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear localization signal

<400>  9

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear localization signal

<400>  10

Gly Lys Lys Arg Ser Lys Val 
1               5           


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear localization signal

<400>  11

Lys Ser Arg Lys Arg Lys Leu 
1               5           


<210>  12
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear localization signal

<400>  12

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


Leu Asp Lys 
            


<210>  13
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear localization signal

<400>  13

Arg Lys Lys Arg Lys Thr Glu Glu Glu Ser Pro Leu Lys Asp Lys Ala 
1               5                   10                  15      


Lys Lys Ser Lys 
            20  


<210>  14
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear localization signal

<400>  14

Lys Asp Cys Val Met Asn Lys His His Arg Asn Arg Cys Gln Tyr Cys 
1               5                   10                  15      


Arg Leu Gln Arg 
            20  


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear localization signal

<400>  15

Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210>  16
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nuclear localization signal

<400>  16

Lys Lys Tyr Glu Asn Val Val Ile Lys Arg Ser Pro Arg Lys Arg Gly 
1               5                   10                  15      


Arg Pro Arg Lys 
            20  


<210>  17
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic PTD-PA-TFAM peptide construct

<400>  17

Met Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Gly Glu Gly Asp 
1               5                   10                  15      


Ile Met Gly Glu Trp Gly Asn Glu Ile Phe Gly Ala Ile Ala Gly Phe 
            20                  25                  30          


Leu Gly Gly Glu His Asp Glu Ala Gln Gln Asn Ala Phe Tyr Gln Val 
        35                  40                  45              


Leu Asn Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln 
    50                  55                  60                  


Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Val Leu Gly Glu Ala 
65                  70                  75                  80  


His Asp Glu Ala Gln Gln Asn Ala Phe Tyr Gln Val Leu Asn Met Pro 
                85                  90                  95      


Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp 
            100                 105                 110         


Asp Pro Ser Gln Ser Ala Asn Val Leu Gly Glu Ala Gly Glu Gly Ser 
        115                 120                 125             


Ser Val Leu Ala Ser Cys Pro Lys Lys Pro Val Ser Ser Tyr Leu Arg 
    130                 135                 140                 


Phe Ser Lys Glu Gln Leu Pro Ile Phe Lys Ala Gln Asn Pro Asp Ala 
145                 150                 155                 160 


Lys Thr Thr Glu Leu Ile Arg Arg Ile Ala Gln Arg Trp Arg Glu Leu 
                165                 170                 175     


Pro Asp Ser Lys Lys Lys Ile Tyr Gln Asp Ala Tyr Arg Ala Glu Trp 
            180                 185                 190         


Gln Val Tyr Lys Glu Glu Ile Ser Arg Phe Lys Glu Gln Leu Thr Pro 
        195                 200                 205             


Ser Gln Ile Met Ser Leu Glu Lys Glu Ile Met Asp Lys His Leu Lys 
    210                 215                 220                 


Arg Lys Ala Met Thr Lys Lys Lys Glu Leu Thr Leu Leu Gly Lys Pro 
225                 230                 235                 240 


Lys Arg Pro Arg Ser Ala Tyr Asn Val Tyr Val Ala Glu Arg Phe Gln 
                245                 250                 255     


Glu Ala Lys Gly Asp Ser Pro Gln Glu Lys Leu Lys Thr Val Lys Glu 
            260                 265                 270         


Asn Trp Lys Asn Leu Ser Asp Ser Glu Lys Glu Leu Tyr Ile Gln His 
        275                 280                 285             


Ala Lys Glu Asp Glu Thr Arg Tyr His Asn Glu Met Lys Ser Trp Glu 
    290                 295                 300                 


Glu Gln Met Ile Glu Val Gly Arg Lys Asp Leu Leu Arg Arg Thr Ile 
305                 310                 315                 320 


Lys Lys Gln Arg Lys Tyr Gly Ala Glu Glu Cys 
                325                 330     


<210>  18
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion protein

<400>  18

Met Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Gly Glu Gly Asp 
1               5                   10                  15      


Ile Met Gly Glu Trp Gly Asn Glu Ile Phe Gly Ala Ile Ala Gly Phe 
            20                  25                  30          


Leu Gly Gly Glu Met Leu Ser Arg Ala Val Cys Gly Thr Ser Arg Gln 
        35                  40                  45              


Leu Pro Pro Val Leu Gly Tyr Leu Gly Ser Arg Gln Ser Ser Val Leu 
    50                  55                  60                  


Ala Ser Cys Pro Lys Lys Pro Val Ser Ser Tyr Leu Arg Phe Ser Lys 
65                  70                  75                  80  


Glu Gln Leu Pro Ile Phe Lys Ala Gln Asn Pro Asp Ala Lys Thr Thr 
                85                  90                  95      


Glu Leu Ile Arg Arg Ile Ala Gln Arg Trp Arg Glu Leu Pro Asp Ser 
            100                 105                 110         


Lys Lys Lys Ile Tyr Gln Asp Ala Tyr Arg Ala Glu Trp Gln Val Tyr 
        115                 120                 125             


Lys Glu Glu Ile Ser Arg Phe Lys Glu Gln Leu Thr Pro Ser Gln Ile 
    130                 135                 140                 


Met Ser Leu Glu Lys Glu Ile Met Asp Lys His Leu Lys Arg Lys Ala 
145                 150                 155                 160 


Met Thr Lys Lys Lys Glu Leu Thr Leu Leu Gly Lys Pro Lys Arg Pro 
                165                 170                 175     


Arg Ser Ala Tyr Asn Val Tyr Val Ala Glu Arg Phe Gln Glu Ala Lys 
            180                 185                 190         


Gly Asp Ser Pro Gln Glu Lys Leu Lys Thr Val Lys Glu Asn Trp Lys 
        195                 200                 205             


Asn Leu Ser Asp Ser Glu Lys Glu Leu Tyr Ile Gln His Ala Lys Glu 
    210                 215                 220                 


Asp Glu Thr Arg Tyr His Asn Glu Met Lys Ser Trp Glu Glu Gln Met 
225                 230                 235                 240 


Ile Glu Val Gly Arg Lys Asp Leu Leu Arg Arg Thr Ile Lys Lys Gln 
                245                 250                 255     


Arg Lys Tyr Gly Ala Glu Glu Cys 
            260                 


<210>  19
<211>  795
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion nuclec acid encoding fusion protein

<400>  19
atgcggcgac gcagacgtcg tcgtcggcgg cgtcgcggcg agggtgatat tatgggtgaa     60

tgggggaacg aaattttcgg agcgatcgct ggttttctcg gtggagaaat gttatcacgc    120

gcggtatgtg gcaccagcag gcagctgcct ccagtccttg gctatctggg ttcccgccag    180

tcatcggtgt tagcatcatg tccgaaaaaa cctgtctcgt cgtacctgcg cttctccaaa    240

gagcagctgc cgatttttaa agcgcaaaat ccggatgcta aaacgactga actgattcgc    300

cgcattgcac aacgctggcg cgaactcccg gacagtaaaa aaaaaattta tcaggacgcc    360

tatcgggctg aatggcaggt ctataaagag gagatctcac gcttcaaaga acaattaacc    420

ccgagtcaaa taatgtctct ggaaaaagaa atcatggata aacacttaaa acgaaaggcg    480

atgacgaaga aaaaagaact gaccctgcta ggtaaaccta agcgtccgcg ctctgcgtat    540

aatgtgtacg tggcagaacg ttttcaggag gccaaagggg attctccgca agaaaaactg    600

aagaccgtca aagaaaattg gaaaaacctg tctgatagcg aaaaagaact gtacattcag    660

cacgctaaag aagatgagac gcggtatcac aacgaaatga aatcttggga agagcagatg    720

atcgaggtcg gtcggaagga tcttctccgt cgaaccatca aaaaacagcg taaatatgga    780

gcagaagagt gctga                                                     795


