                         SEQUENCE LISTING

<110>  ZymoGenetics, LLC
       Bristol-Myers Squibb Company
 
<120>  SINGLE CHAIN FC TYPE III INTERFERONS AND METHODS OF USING SAME

<130>  08-15PC

<150>  US 61/116,601
<151>  2008-11-20

<150>  US 61/104,946
<151>  2008-10-13

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Pro Val Pro Thr Ser Lys Pro Thr Thr Thr Gly Lys Gly Cys His 
1               5                   10                  15      


Ile Gly Arg Phe Lys Ser Leu Ser Pro Gln Glu Leu Ala Ser Phe Lys 
            20                  25                  30          


Lys Ala Arg Asp Ala Leu Glu Glu Ser Leu Lys Leu Lys Asn Trp Ser 
        35                  40                  45              


Cys Ser Ser Pro Val Phe Pro Gly Asn Trp Asp Leu Arg Leu Leu Gln 
    50                  55                  60                  


Val Arg Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu 
65                  70                  75                  80  


Lys Val Leu Glu Ala Ala Ala Gly Pro Ala Leu Glu Asp Val Leu Asp 
                85                  90                  95      


Gln Pro Leu His Thr Leu His His Ile Leu Ser Gln Leu Gln Ala Cys 
            100                 105                 110         


Ile Gln Pro Gln Pro Thr Ala Gly Pro Arg Pro Arg Gly Arg Leu His 
        115                 120                 125             


His Trp Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser Ala Gly 
    130                 135                 140                 


Cys Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg 
145                 150                 155                 160 


Asp Leu Lys Tyr Val Ala Asp Gly Asn Leu Cys Leu Arg Thr Ser Thr 
                165                 170                 175     


His Pro Glu Ser Thr 
            180     


<210>  2
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  2

Val Pro Val Ala Arg Leu His Gly Ala Leu Pro Asp Ala Arg Gly Cys 
1               5                   10                  15      


His Ile Ala Gln Phe Lys Ser Leu Ser Pro Gln Glu Leu Gln Ala Phe 
            20                  25                  30          


Lys Arg Ala Lys Asp Ala Leu Glu Glu Ser Leu Leu Leu Lys Asp Cys 
        35                  40                  45              


Arg Cys His Ser Arg Leu Phe Pro Arg Thr Trp Asp Leu Arg Gln Leu 
    50                  55                  60                  


Gln Val Arg Glu Arg Pro Met Ala Leu Glu Ala Glu Leu Ala Leu Thr 
65                  70                  75                  80  


Leu Lys Val Leu Glu Ala Thr Ala Asp Thr Asp Pro Ala Leu Val Asp 
                85                  90                  95      


Val Leu Asp Gln Pro Leu His Thr Leu His His Ile Leu Ser Gln Phe 
            100                 105                 110         


Arg Ala Cys Ile Gln Pro Gln Pro Thr Ala Gly Pro Arg Thr Arg Gly 
        115                 120                 125             


Arg Leu His His Trp Leu Tyr Arg Leu Gln Glu Ala Pro Lys Lys Glu 
    130                 135                 140                 


Ser Pro Gly Cys Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu 
145                 150                 155                 160 


Leu Thr Arg Asp Leu Asn Cys Val Ala Ser Gly Asp Leu Cys Val 
                165                 170                 175 


<210>  3
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  3

Val Pro Val Ala Arg Leu Arg Gly Ala Leu Pro Asp Ala Arg Gly Cys 
1               5                   10                  15      


His Ile Ala Gln Phe Lys Ser Leu Ser Pro Gln Glu Leu Gln Ala Phe 
            20                  25                  30          


Lys Arg Ala Lys Asp Ala Leu Glu Glu Ser Leu Leu Leu Lys Asp Cys 
        35                  40                  45              


Lys Cys Arg Ser Arg Leu Phe Pro Arg Thr Trp Asp Leu Arg Gln Leu 
    50                  55                  60                  


Gln Val Arg Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr 
65                  70                  75                  80  


Leu Lys Val Leu Glu Ala Thr Ala Asp Thr Asp Pro Ala Leu Gly Asp 
                85                  90                  95      


Val Leu Asp Gln Pro Leu His Thr Leu His His Ile Leu Ser Gln Leu 
            100                 105                 110         


Arg Ala Cys Ile Gln Pro Gln Pro Thr Ala Gly Pro Arg Thr Arg Gly 
        115                 120                 125             


Arg Leu His His Trp Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu 
    130                 135                 140                 


Ser Pro Gly Cys Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu 
145                 150                 155                 160 


Leu Thr Arg Asp Leu Asn Cys Val Ala Ser Gly Asp Leu Cys Val 
                165                 170                 175 


<210>  4
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  4

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  5
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  MISC_FEATURE
<222>  (2)..(5)
<223>  Gly or is absent

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Ala, Val, Leu, Ile, Met, Phe, Trp, Pro, Gly, Ser, Thr, Cys, Tyr, 
       Asn, Gln, Lys Arg, His, Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (8)..(11)
<223>  Gly or is absent

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Ala, Val, Leu, Ile, Met, Phe, Trp, Pro, Gly, Ser, Thr, Cys, Tyr, 
       Asn, Gln, Lys Arg, His, Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (14)..(17)
<223>  Gly or is absent

<400>  5

Gly Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa 
1               5                   10                  15      


Xaa 
    


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Ala, Val, Leu, Ile, Met, Phe, Trp, Pro, Gly, Ser, Thr, Cys, Tyr, 
       Asn, Gln, Lys Arg, His, Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Ala, Val, Leu, Ile, Met, Phe, Trp, Pro, Gly, Ser, Thr, Cys, Tyr, 
       Asn, Gln, Lys Arg, His, Asp or Glu

<400>  6

Gly Gly Gly Xaa Gly Gly Gly Xaa Gly Gly Gly 
1               5                   10      


<210>  7
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  MISC_FEATURE
<222>  (2)..(12)
<223>  Gly or is absent

<220>
<221>  MISC_FEATURE
<222>  (15)..(25)
<223>  Gly or is absent

<400>  7

Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Gly Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25  


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  8

Gly Gly Gly Gly Gly Cys Gly Gly Gly Gly Gly 
1               5                   10      


<210>  9
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  9

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        35                  40      


<210>  10
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  10

Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
1               5                   10                  15      


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Ser Arg Pro Ala 
            20                  25                  30          


Ala Gly 
        


<210>  11
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  11

Glu Pro Arg Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  12
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  12

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  13
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  13

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly 
225                 230     


<210>  14
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  14

Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        35                  40                  45              


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  


Thr Lys Pro Arg Glu Glu Gln Tyr Glu Ser Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    130                 135                 140                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                165                 170                 175     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            180                 185                 190         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        195                 200                 205             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220             


<210>  15
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  15

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  16
<211>  489
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(489)

<400>  16
cgt ttc aaa tct ctg tct ccg cag gaa ctg gct tct ttc aaa aaa gct         48
Arg Phe Lys Ser Leu Ser Pro Gln Glu Leu Ala Ser Phe Lys Lys Ala           
1               5                   10                  15                

cgt gac gct ctg gaa gaa tct ctg aaa ctg aaa aac tgg tct tgc tct         96
Arg Asp Ala Leu Glu Glu Ser Leu Lys Leu Lys Asn Trp Ser Cys Ser           
            20                  25                  30                    

tct ccg gtt ttc ccg ggt aac tgg gat ctg cgt ctg ctg cag gtt cgt        144
Ser Pro Val Phe Pro Gly Asn Trp Asp Leu Arg Leu Leu Gln Val Arg           
        35                  40                  45                        

gaa cgt ccg gtt gct ctg gaa gct gaa ctg gct ctg acc ctg aaa gtt        192
Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val           
    50                  55                  60                            

ctg gaa gct gct gca ggt cct gct ctg gaa gat gtt ctg gat cag ccg        240
Leu Glu Ala Ala Ala Gly Pro Ala Leu Glu Asp Val Leu Asp Gln Pro           
65                  70                  75                  80            

ctg cac act ctg cac cac atc ctg tct cag ctg cag gct tct att caa        288
Leu His Thr Leu His His Ile Leu Ser Gln Leu Gln Ala Ser Ile Gln           
                85                  90                  95                

ccg caa ccg acc gct ggt ccg cgt ccg cgt ggt cgt ctg cac cac tgg        336
Pro Gln Pro Thr Ala Gly Pro Arg Pro Arg Gly Arg Leu His His Trp           
            100                 105                 110                   

ctg cat cgt ctg cag gaa gct ccg aaa aaa gaa tct gct ggt tgc ctg        384
Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser Ala Gly Cys Leu           
        115                 120                 125                       

gaa gct tct gtt acc ttc aac ctg ttc cgt ctg ctg acc cgt gat ctg        432
Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu           
    130                 135                 140                           

aaa tac gtt gct gat ggt aac ctg tct ctg cgt acc tct acc cat ccg        480
Lys Tyr Val Ala Asp Gly Asn Leu Ser Leu Arg Thr Ser Thr His Pro           
145                 150                 155                 160           

gaa tct acc                                                            489
Glu Ser Thr                                                               
                                                                          


<210>  17
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  17

Arg Phe Lys Ser Leu Ser Pro Gln Glu Leu Ala Ser Phe Lys Lys Ala 
1               5                   10                  15      


Arg Asp Ala Leu Glu Glu Ser Leu Lys Leu Lys Asn Trp Ser Cys Ser 
            20                  25                  30          


Ser Pro Val Phe Pro Gly Asn Trp Asp Leu Arg Leu Leu Gln Val Arg 
        35                  40                  45              


Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val 
    50                  55                  60                  


Leu Glu Ala Ala Ala Gly Pro Ala Leu Glu Asp Val Leu Asp Gln Pro 
65                  70                  75                  80  


Leu His Thr Leu His His Ile Leu Ser Gln Leu Gln Ala Ser Ile Gln 
                85                  90                  95      


Pro Gln Pro Thr Ala Gly Pro Arg Pro Arg Gly Arg Leu His His Trp 
            100                 105                 110         


Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser Ala Gly Cys Leu 
        115                 120                 125             


Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu 
    130                 135                 140                 


Lys Tyr Val Ala Asp Gly Asn Leu Ser Leu Arg Thr Ser Thr His Pro 
145                 150                 155                 160 


Glu Ser Thr 
            


<210>  18
<211>  483
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(483)

<400>  18
aaa cca acc acc act ggt aaa ggt tgc cac atc ggt cgt ttc aaa tct         48
Lys Pro Thr Thr Thr Gly Lys Gly Cys His Ile Gly Arg Phe Lys Ser           
1               5                   10                  15                

ctg tct ccg cag gaa ctg gct tct ttc aaa aaa gct cgt gac gct ctg         96
Leu Ser Pro Gln Glu Leu Ala Ser Phe Lys Lys Ala Arg Asp Ala Leu           
            20                  25                  30                    

gaa gaa tct ctg aaa ctg aaa aac tgg tct tgc tct tct ccg gtt ttc        144
Glu Glu Ser Leu Lys Leu Lys Asn Trp Ser Cys Ser Ser Pro Val Phe           
        35                  40                  45                        

ccg ggt aac tgg gat ctg cgt ctg ctg cag gtt cgt gaa cgt ccg gtt        192
Pro Gly Asn Trp Asp Leu Arg Leu Leu Gln Val Arg Glu Arg Pro Val           
    50                  55                  60                            

gct ctg gaa gct gaa ctg gct ctg acc ctg aaa gtt ctg gaa gct gct        240
Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val Leu Glu Ala Ala           
65                  70                  75                  80            

gca ggt cct gct ctg gaa gat gtt ctg gat cag ccg ctg cac act ctg        288
Ala Gly Pro Ala Leu Glu Asp Val Leu Asp Gln Pro Leu His Thr Leu           
                85                  90                  95                

cac cac atc ctg tct cag ctg cag gct tgc att caa ccg caa ccg acc        336
His His Ile Leu Ser Gln Leu Gln Ala Cys Ile Gln Pro Gln Pro Thr           
            100                 105                 110                   

gct ggt ccg cgt ccg cgt ggt cgt ctg cac cac tgg ctg cat cgt ctg        384
Ala Gly Pro Arg Pro Arg Gly Arg Leu His His Trp Leu His Arg Leu           
        115                 120                 125                       

cag gaa gct ccg aaa aaa gaa tct gct ggt tgc ctg gaa gct tct gtt        432
Gln Glu Ala Pro Lys Lys Glu Ser Ala Gly Cys Leu Glu Ala Ser Val           
    130                 135                 140                           

acc ttc aac ctg ttc cgt ctg ctg acc cgt gat ctg aaa tac gtt gct        480
Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu Lys Tyr Val Ala           
145                 150                 155                 160           

gat                                                                    483
Asp                                                                       
                                                                          


<210>  19
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  19

Lys Pro Thr Thr Thr Gly Lys Gly Cys His Ile Gly Arg Phe Lys Ser 
1               5                   10                  15      


Leu Ser Pro Gln Glu Leu Ala Ser Phe Lys Lys Ala Arg Asp Ala Leu 
            20                  25                  30          


Glu Glu Ser Leu Lys Leu Lys Asn Trp Ser Cys Ser Ser Pro Val Phe 
        35                  40                  45              


Pro Gly Asn Trp Asp Leu Arg Leu Leu Gln Val Arg Glu Arg Pro Val 
    50                  55                  60                  


Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val Leu Glu Ala Ala 
65                  70                  75                  80  


Ala Gly Pro Ala Leu Glu Asp Val Leu Asp Gln Pro Leu His Thr Leu 
                85                  90                  95      


His His Ile Leu Ser Gln Leu Gln Ala Cys Ile Gln Pro Gln Pro Thr 
            100                 105                 110         


Ala Gly Pro Arg Pro Arg Gly Arg Leu His His Trp Leu His Arg Leu 
        115                 120                 125             


Gln Glu Ala Pro Lys Lys Glu Ser Ala Gly Cys Leu Glu Ala Ser Val 
    130                 135                 140                 


Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu Lys Tyr Val Ala 
145                 150                 155                 160 


Asp 
    


<210>  20
<211>  471
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(471)

<400>  20
aaa cca acc acc act ggt aaa ggt tgc cac atc ggt cgt ttc aaa tct         48
Lys Pro Thr Thr Thr Gly Lys Gly Cys His Ile Gly Arg Phe Lys Ser           
1               5                   10                  15                

ctg tct ccg cag gaa ctg gct tct ttc aaa aaa gct cgt gac gct ctg         96
Leu Ser Pro Gln Glu Leu Ala Ser Phe Lys Lys Ala Arg Asp Ala Leu           
            20                  25                  30                    

gaa gaa tct ctg aaa ctg aaa aac tgg tct tgc tct tct ccg gtt ttc        144
Glu Glu Ser Leu Lys Leu Lys Asn Trp Ser Cys Ser Ser Pro Val Phe           
        35                  40                  45                        

ccg ggt aac tgg gat ctg cgt ctg ctg cag gtt cgt gaa cgt ccg gtt        192
Pro Gly Asn Trp Asp Leu Arg Leu Leu Gln Val Arg Glu Arg Pro Val           
    50                  55                  60                            

gct ctg gaa gct gaa ctg gct ctg acc ctg aaa gtt ctg gaa gct gct        240
Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val Leu Glu Ala Ala           
65                  70                  75                  80            

gca ggt cct gct ctg gaa gat gtt ctg gat cag ccg ctg cac act ctg        288
Ala Gly Pro Ala Leu Glu Asp Val Leu Asp Gln Pro Leu His Thr Leu           
                85                  90                  95                

cac cac atc ctg tct cag ctg cag gct tgc att caa ccg caa ccg acc        336
His His Ile Leu Ser Gln Leu Gln Ala Cys Ile Gln Pro Gln Pro Thr           
            100                 105                 110                   

gct ggt ccg cgt ccg cgt ggt cgt ctg cac cac tgg ctg cat cgt ctg        384
Ala Gly Pro Arg Pro Arg Gly Arg Leu His His Trp Leu His Arg Leu           
        115                 120                 125                       

cag gaa gct ccg aaa aaa gaa tct gct ggt tgc ctg gaa gct tct gtt        432
Gln Glu Ala Pro Lys Lys Glu Ser Ala Gly Cys Leu Glu Ala Ser Val           
    130                 135                 140                           

acc ttc aac ctg ttc cgt ctg ctg acc cgt gat ctg aaa                    471
Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu Lys                       
145                 150                 155                               


<210>  21
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  21

Lys Pro Thr Thr Thr Gly Lys Gly Cys His Ile Gly Arg Phe Lys Ser 
1               5                   10                  15      


Leu Ser Pro Gln Glu Leu Ala Ser Phe Lys Lys Ala Arg Asp Ala Leu 
            20                  25                  30          


Glu Glu Ser Leu Lys Leu Lys Asn Trp Ser Cys Ser Ser Pro Val Phe 
        35                  40                  45              


Pro Gly Asn Trp Asp Leu Arg Leu Leu Gln Val Arg Glu Arg Pro Val 
    50                  55                  60                  


Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val Leu Glu Ala Ala 
65                  70                  75                  80  


Ala Gly Pro Ala Leu Glu Asp Val Leu Asp Gln Pro Leu His Thr Leu 
                85                  90                  95      


His His Ile Leu Ser Gln Leu Gln Ala Cys Ile Gln Pro Gln Pro Thr 
            100                 105                 110         


Ala Gly Pro Arg Pro Arg Gly Arg Leu His His Trp Leu His Arg Leu 
        115                 120                 125             


Gln Glu Ala Pro Lys Lys Glu Ser Ala Gly Cys Leu Glu Ala Ser Val 
    130                 135                 140                 


Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu Lys 
145                 150                 155         


<210>  22
<211>  447
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(447)

<400>  22
cgt ttc aaa tct ctg tct ccg cag gaa ctg gct tct ttc aaa aaa gct         48
Arg Phe Lys Ser Leu Ser Pro Gln Glu Leu Ala Ser Phe Lys Lys Ala           
1               5                   10                  15                

cgt gac gct ctg gaa gaa tct ctg aaa ctg aaa aac tgg tct tgc tct         96
Arg Asp Ala Leu Glu Glu Ser Leu Lys Leu Lys Asn Trp Ser Cys Ser           
            20                  25                  30                    

tct ccg gtt ttc ccg ggt aac tgg gat ctg cgt ctg ctg cag gtt cgt        144
Ser Pro Val Phe Pro Gly Asn Trp Asp Leu Arg Leu Leu Gln Val Arg           
        35                  40                  45                        

gaa cgt ccg gtt gct ctg gaa gct gaa ctg gct ctg acc ctg aaa gtt        192
Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val           
    50                  55                  60                            

ctg gaa gct gct gca ggt cct gct ctg gaa gat gtt ctg gat cag ccg        240
Leu Glu Ala Ala Ala Gly Pro Ala Leu Glu Asp Val Leu Asp Gln Pro           
65                  70                  75                  80            

ctg cac act ctg cac cac atc ctg tct cag ctg cag gct tct att caa        288
Leu His Thr Leu His His Ile Leu Ser Gln Leu Gln Ala Ser Ile Gln           
                85                  90                  95                

ccg caa ccg acc gct ggt ccg cgt ccg cgt ggt cgt ctg cac cac tgg        336
Pro Gln Pro Thr Ala Gly Pro Arg Pro Arg Gly Arg Leu His His Trp           
            100                 105                 110                   

ctg cat cgt ctg cag gaa gct ccg aaa aaa gaa tct gct ggt tgc ctg        384
Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser Ala Gly Cys Leu           
        115                 120                 125                       

gaa gct tct gtt acc ttc aac ctg ttc cgt ctg ctg acc cgt gat ctg        432
Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu           
    130                 135                 140                           

aaa tac gtt gct gat                                                    447
Lys Tyr Val Ala Asp                                                       
145                                                                       


<210>  23
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  23

Arg Phe Lys Ser Leu Ser Pro Gln Glu Leu Ala Ser Phe Lys Lys Ala 
1               5                   10                  15      


Arg Asp Ala Leu Glu Glu Ser Leu Lys Leu Lys Asn Trp Ser Cys Ser 
            20                  25                  30          


Ser Pro Val Phe Pro Gly Asn Trp Asp Leu Arg Leu Leu Gln Val Arg 
        35                  40                  45              


Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val 
    50                  55                  60                  


Leu Glu Ala Ala Ala Gly Pro Ala Leu Glu Asp Val Leu Asp Gln Pro 
65                  70                  75                  80  


Leu His Thr Leu His His Ile Leu Ser Gln Leu Gln Ala Ser Ile Gln 
                85                  90                  95      


Pro Gln Pro Thr Ala Gly Pro Arg Pro Arg Gly Arg Leu His His Trp 
            100                 105                 110         


Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser Ala Gly Cys Leu 
        115                 120                 125             


Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu 
    130                 135                 140                 


Lys Tyr Val Ala Asp 
145                 


<210>  24
<211>  435
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(435)

<400>  24
cgt ttc aaa tct ctg tct ccg cag gaa ctg gct tct ttc aaa aaa gct         48
Arg Phe Lys Ser Leu Ser Pro Gln Glu Leu Ala Ser Phe Lys Lys Ala           
1               5                   10                  15                

cgt gac gct ctg gaa gaa tct ctg aaa ctg aaa aac tgg tct tgc tct         96
Arg Asp Ala Leu Glu Glu Ser Leu Lys Leu Lys Asn Trp Ser Cys Ser           
            20                  25                  30                    

tct ccg gtt ttc ccg ggt aac tgg gat ctg cgt ctg ctg cag gtt cgt        144
Ser Pro Val Phe Pro Gly Asn Trp Asp Leu Arg Leu Leu Gln Val Arg           
        35                  40                  45                        

gaa cgt ccg gtt gct ctg gaa gct gaa ctg gct ctg acc ctg aaa gtt        192
Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val           
    50                  55                  60                            

ctg gaa gct gct gca ggt cct gct ctg gaa gat gtt ctg gat cag ccg        240
Leu Glu Ala Ala Ala Gly Pro Ala Leu Glu Asp Val Leu Asp Gln Pro           
65                  70                  75                  80            

ctg cac act ctg cac cac atc ctg tct cag ctg cag gct tct att caa        288
Leu His Thr Leu His His Ile Leu Ser Gln Leu Gln Ala Ser Ile Gln           
                85                  90                  95                

ccg caa ccg acc gct ggt ccg cgt ccg cgt ggt cgt ctg cac cac tgg        336
Pro Gln Pro Thr Ala Gly Pro Arg Pro Arg Gly Arg Leu His His Trp           
            100                 105                 110                   

ctg cat cgt ctg cag gaa gct ccg aaa aaa gaa tct gct ggt tgc ctg        384
Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser Ala Gly Cys Leu           
        115                 120                 125                       

gaa gct tct gtt acc ttc aac ctg ttc cgt ctg ctg acc cgt gat ctg        432
Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu           
    130                 135                 140                           

aaa                                                                    435
Lys                                                                       
145                                                                       


<210>  25
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  25

Arg Phe Lys Ser Leu Ser Pro Gln Glu Leu Ala Ser Phe Lys Lys Ala 
1               5                   10                  15      


Arg Asp Ala Leu Glu Glu Ser Leu Lys Leu Lys Asn Trp Ser Cys Ser 
            20                  25                  30          


Ser Pro Val Phe Pro Gly Asn Trp Asp Leu Arg Leu Leu Gln Val Arg 
        35                  40                  45              


Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val 
    50                  55                  60                  


Leu Glu Ala Ala Ala Gly Pro Ala Leu Glu Asp Val Leu Asp Gln Pro 
65                  70                  75                  80  


Leu His Thr Leu His His Ile Leu Ser Gln Leu Gln Ala Ser Ile Gln 
                85                  90                  95      


Pro Gln Pro Thr Ala Gly Pro Arg Pro Arg Gly Arg Leu His His Trp 
            100                 105                 110         


Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser Ala Gly Cys Leu 
        115                 120                 125             


Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu 
    130                 135                 140                 


Lys 
145 


