                         SEQUENCE LISTING

<110>  Institut Municipal d Investigaci Mdica (IMIM)
 
<120>  Use of Cyclin O in a medical setting

<130>  N1199 PCT S3

<150>  EP 08 01 8163.9
<151>  2008-10-16

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  1531
<212>  DNA
<213>  Homo sapiens

<400>  1
ctccccccgg cgggccgcgg aggcgacgcg ctgcctgcgc cctgaggcga gtggttctcc       60

agccggaaaa tcgcggctcc ggtgccgctc tgggctcagc cagtgagagg ccgggggtgt      120

ggtagagaga aggagccggc cgggtactta ggaccgcgcc agcctctgag cccggcctcc      180

ttcgcacttt cgagtgcgcg tttgctgccc gccgcagccc gggcgttgaa ggtagtaaag      240

cggccacccg gccgcatcat ggtgaccccc tgtcccacca gcccctcgag ccccgccgcc      300

cgagcgggga ggcgggacaa cgaccagaac cttcgcgccc cggtgaagaa gagcaggcgt      360

ccgcgcctcc ggaggaagca gccgctgcat cccctgaacc cgtgcccgct cccgggagac      420

tccggcattt gcgacctgtt cgagtccccc agctccggct cagacggcgc agagagcccc      480

tctgcggcgc ggggtggtag ccccctgccc ggcccggccc agcccgtggc gcagctagat      540

ctacagacct tccgcgacta cggccagagc tgctacgcct tccgcaaggc gcaggagagc      600

cacttccacc cgcgggaggc gctggcacgg cagccacaag tgacggcgga atcccgctgt      660

aagctgctca gctggctgat cccggtgcac cgccaattcg gcctctcctt cgagtcgctg      720

tgcctgacgg tgaacactct ggaccgcttc ctcaccacca cgccggtggc tgcagactgc      780

ttccagctgc ttggggtcac ctccttgctc atcgcttgca aacaggtgga ggtgcacccg      840

ccgcgcgtga agcagcttct ggccctctgc tgcggcgcct tctcccggca gcagctctgc      900

aacctcgagt gcatcgtgct gcacaagctg cacttcaccc tgggtgcgcc caccattagc      960

ttcttcctgg agcatttcac gcacgctcgc gtggaggcgg ggcaggctga ggcctccgaa     1020

gctctggaag cgcaagccct ggcgcggggg gtggcagagc tgagtctggc cgactatgcc     1080

ttcaccagct actccccttc cctcctggcg atctgctgcc tggcgctggc ggaccgcatg     1140

ctgcgggtct cgcggcccgt ggacttgcga ctgggagacc acccggaggc ggcgctggag     1200

gactgtatgg gcaagttgca gctgctggtg gccataaaca gtacttcctt gactcacatg     1260

ctgcccgttc agatctgcga gaagtgcagc ctgcccccga gctcgaaata aaacagatcc     1320

ttcgtttcct tttagtccct ggcccggctg ctggacctct cccgtagcct cagaagagtg     1380

cagtactggt ccacagagaa ggcttcagga cctgcttggt cagctgcagg ttgtaaatag     1440

tgtacgatac tagcatctgg tattttattt attttgcagc gagcacatga ggaagctgag     1500

tctttcacca ataaacagtt gtggtttgtc t                                    1531


<210>  2
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Val Thr Pro Cys Pro Thr Ser Pro Ser Ser Pro Ala Ala Arg Ala 
1               5                   10                  15      


Gly Arg Arg Asp Asn Asp Gln Asn Leu Arg Ala Pro Val Lys Lys Ser 
            20                  25                  30          


Arg Arg Pro Arg Leu Arg Arg Lys Gln Pro Leu His Pro Leu Asn Pro 
        35                  40                  45              


Cys Pro Leu Pro Gly Asp Ser Gly Ile Cys Asp Leu Phe Glu Ser Pro 
    50                  55                  60                  


Ser Ser Gly Ser Asp Gly Ala Glu Ser Pro Ser Ala Ala Arg Gly Gly 
65                  70                  75                  80  


Ser Pro Leu Pro Gly Pro Ala Gln Pro Val Ala Gln Leu Asp Leu Gln 
                85                  90                  95      


Thr Phe Arg Asp Tyr Gly Gln Ser Cys Tyr Ala Phe Arg Lys Ala Gln 
            100                 105                 110         


Glu Ser His Phe His Pro Arg Glu Ala Leu Ala Arg Gln Pro Gln Val 
        115                 120                 125             


Thr Ala Glu Ser Arg Cys Lys Leu Leu Ser Trp Leu Ile Pro Val His 
    130                 135                 140                 


Arg Gln Phe Gly Leu Ser Phe Glu Ser Leu Cys Leu Thr Val Asn Thr 
145                 150                 155                 160 


Leu Asp Arg Phe Leu Thr Thr Thr Pro Val Ala Ala Asp Cys Phe Gln 
                165                 170                 175     


Leu Leu Gly Val Thr Ser Leu Leu Ile Ala Cys Lys Gln Val Glu Val 
            180                 185                 190         


His Pro Pro Arg Val Lys Gln Leu Leu Ala Leu Cys Cys Gly Ala Phe 
        195                 200                 205             


Ser Arg Gln Gln Leu Cys Asn Leu Glu Cys Ile Val Leu His Lys Leu 
    210                 215                 220                 


His Phe Thr Leu Gly Ala Pro Thr Ile Ser Phe Phe Leu Glu His Phe 
225                 230                 235                 240 


Thr His Ala Arg Val Gly Ala Gly Gln Ala Glu Ala Ser Glu Ala Leu 
                245                 250                 255     


Glu Ala Gln Ala Leu Ala Arg Gly Val Ala Glu Leu Ser Leu Ala Asp 
            260                 265                 270         


Tyr Ala Phe Thr Ser Tyr Ser Pro Ser Leu Leu Ala Ile Cys Cys Leu 
        275                 280                 285             


Ala Leu Ala Asp Arg Met Leu Arg Val Ser Arg Pro Val Asp Leu Arg 
    290                 295                 300                 


Leu Gly Asp His Pro Glu Ala Ala Leu Glu Asp Cys Met Gly Lys Leu 
305                 310                 315                 320 


Gln Leu Leu Val Ala Ile Asn Ser Thr Ser Leu Thr His Met Leu Pro 
                325                 330                 335     


Val Gln Ile Cys Glu Lys Cys Ser Leu Pro Pro Ser Ser Lys 
            340                 345                 350 


<210>  3
<211>  1345
<212>  DNA
<213>  Homo sapiens

<400>  3
ctccccccgg cgggccgcgg aggcgacgcg ctgcctgcgc cctgaggcga gtggttctcc       60

agccggaaaa tcgcggctcc ggtgccgctc tgggctcagc cagtgagagg ccgggggtgt      120

ggtagagaga aggagccggc cgggtactta ggaccgcgcc agcctctgag cccggcctcc      180

ttcgcacttt cgagtgcgcg tttgctgccc gccgcagccc gggcgttgaa ggtagtaaag      240

cggccacccg gccgcatcat ggtgaccccc tgtcccacca gcccctcgag ccccgccgcc      300

cgagcgggga ggcgggacaa cgaccagaac cttcgcgccc cggtgaagaa gagcaggcgt      360

ccgcgcctcc ggaggaagca gccgctgcat cccctgaacc cgtgcccgct cccgggagac      420

tccggcattt gcgacctgtt cgagtccccc agctccggct cagacggcgc agagagcccc      480

tctgcggcgc ggggtggtag ccccctgccc ggcccggccc agcccgtggc gcagctagat      540

ctacagacct tccgcgacta cggccagagc tgctacgcct tccgcaaggc gcaggagagc      600

cacttccacc cgcgggaggc gctggcacgg cagccacaag tggaggtgca cccgccgcgc      660

gtgaagcagc ttctggccct ctgctgcggc gccttctccc ggcagcagct ctgcaacctc      720

gagtgcatcg tgctgcacaa gctgcacttc accctgggtg cgcccaccat tagcttcttc      780

ctggagcatt tcacgcacgc tcgcgtggag gcggggcagg ctgaggcctc cgaagctctg      840

gaagcgcaag ccctggcgcg gggggtggca gagctgagtc tggccgacta tgccttcacc      900

agctactccc cttccctcct ggcgatctgc tgcctggcgc tggcggaccg catgctgcgg      960

gtctcgcggc ccgtggactt gcgactggga gaccacccgg aggcggcgct ggaggactgt     1020

atgggcaagt tgcagctgct ggtggccata aacagtactt ccttgactca catgctgccc     1080

gttcagatct gcgagaagtg cagcctgccc ccgagctcga aataaaacag atccttcgtt     1140

tccttttagt ccctggcccg gctgctggac ctctcccgta gcctcagaag agtgcagtac     1200

tggtccacag agaaggcttc aggacctgct tggtcagctg caggttgtaa atagtgtacg     1260

atactagcat ctggtatttt atttattttg cagcgagcac atgaggaagc tgagtctttc     1320

accaataaac agttgtggtt tgtct                                           1345


<210>  4
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Val Thr Pro Cys Pro Thr Ser Pro Ser Ser Pro Ala Ala Arg Ala 
1               5                   10                  15      


Gly Arg Arg Asp Asn Asp Gln Asn Leu Arg Ala Pro Val Lys Lys Ser 
            20                  25                  30          


Arg Arg Pro Arg Leu Arg Arg Lys Gln Pro Leu His Pro Leu Asn Pro 
        35                  40                  45              


Cys Pro Leu Pro Gly Asp Ser Gly Ile Cys Asp Leu Phe Glu Ser Pro 
    50                  55                  60                  


Ser Ser Gly Ser Asp Gly Ala Glu Ser Pro Ser Ala Ala Arg Gly Gly 
65                  70                  75                  80  


Ser Pro Leu Pro Gly Pro Ala Gln Pro Val Ala Gln Leu Asp Leu Gln 
                85                  90                  95      


Thr Phe Arg Asp Tyr Gly Gln Ser Cys Tyr Ala Phe Arg Lys Ala Gln 
            100                 105                 110         


Glu Ser His Phe His Pro Arg Glu Ala Leu Ala Arg Gln Pro Gln Val 
        115                 120                 125             


Glu Val His Pro Pro Arg Val Lys Gln Leu Leu Ala Leu Cys Cys Gly 
    130                 135                 140                 


Ala Phe Ser Arg Gln Gln Leu Cys Asn Leu Glu Cys Ile Val Leu His 
145                 150                 155                 160 


Lys Leu His Phe Thr Leu Gly Ala Pro Thr Ile Ser Phe Phe Leu Glu 
                165                 170                 175     


His Phe Thr His Ala Arg Val Glu Ala Gly Gln Ala Glu Ala Ser Glu 
            180                 185                 190         


Ala Leu Glu Ala Gln Ala Leu Ala Arg Gly Val Ala Glu Leu Ser Leu 
        195                 200                 205             


Ala Asp Tyr Ala Phe Thr Ser Tyr Ser Pro Ser Leu Leu Ala Ile Cys 
    210                 215                 220                 


Cys Leu Ala Leu Ala Asp Arg Met Leu Arg Val Ser Arg Pro Val Asp 
225                 230                 235                 240 


Leu Arg Leu Gly Asp His Pro Glu Ala Ala Leu Glu Asp Cys Met Gly 
                245                 250                 255     


Lys Leu Gln Leu Leu Val Ala Ile Asn Ser Thr Ser Leu Thr His Met 
            260                 265                 270         


Leu Pro Val Gln Ile Cys Glu Lys Cys Ser Leu Pro Pro Ser Ser Lys 
        275                 280                 285             


<210>  5
<211>  1874
<212>  DNA
<213>  mus musculus

<400>  5
agagctgcgc cgccagcggg accggatctt cctcgcagct ctcgcgccga cgctccgggc       60

gtcgtagacg ctaggagcgc tacccgattg taacatggtt accccttgcc ctgccagccc      120

gggcagcccc gccgcgggag ccgggaggcg agacagccac cagaacctcc gcgccccagt      180

gaagaagagc agacgcccgt gcctccggag aaagaagccg ctgcggccgc tgaacgcgtg      240

ttcgctcccg ggagactcgg gcgtctgtga ccttttcgag tcccccagct ccagctcgga      300

cggcgccgac agccccgcag tgtctgcggc gcgggactgc agctccctac tcaaccctgc      360

ccagcccttg acagcgctgg atctccagac cttccgagaa tacggccaga gctgctacga      420

cttccgaaag gcgcaggaga atcttttcca cccgcgggag tcgctggcgc gccagccaca      480

agtgactgcc gaatcgcgct gtaaactgct cagctggctc ctgcaagtcc accgccagtt      540

cggcctctct ttcgagtcgc tgtgtctgac cgtgaatact ctggaccgtt ttctcctcac      600

gacccctgtt gctgcagact gcttccagct gctcggggtc acctgtctgc tcatcgcttg      660

caagcaggta gaggtgcacc cacctcgctt gaaacagctc ctggccctgt gcggcggtgc      720

gttctcccgg cagcagctgt gcaacctgga gtgcatcgtg ctgcataagc tccacttcag      780

cctgggcgcg cccaccatca acttcttcct ggagcacttc actcagtggc gcatggaagc      840

cggccaggct gaggtcaccg aagctctaga ggctcaaacc ctggcccggg gagtggcgga      900

gctgagccta acggattacg cgttcactac ctacacgccg tccctgatgg ctatctgctg      960

cctggcgctg gctgacggat tgctgcagca ccagcacgag atggacctgc gcctgggaga     1020

gcacccagag gccacactgc aagactgtct gggcaagctg cagacgctag tgtccatcaa     1080

tagcagctcc ctgcctcgca ttctgcctcc ccagatctgg gagaggtgca gcctgcccca     1140

gagttggcaa taaaaagcac ccccttgagc tcctttttaa aattccctgg tccctgctcc     1200

gtgccttaag gagaatatgc agtacagatc caaagagaag ttgaggtctc ctacctgtaa     1260

atactgtaca ataacggatt ctttatttat tttgtagtac acaagggcag gggtgacagt     1320

tctggcttgt ctaaatgctg ctgttggcat gcctgactgt ctgcttttcc caggcgaagt     1380

ccatcacgag gtagccaatt ccggaggctc ttccctgctc ccacagtttt actttgtagt     1440

tagctctgtg aaaacaacct ggcaagattt tatatgccac tgttccagaa agcagacaag     1500

tcaaggtggc ttgtccgtat cttaaccccc tccagtcagg aggctgagtt ccctccccca     1560

tgccagtggc ccaaggagaa tgagacaggg ttagaagtca gagtggtctg tgctgtccgg     1620

aaaggcagtg gctgcactaa ctgatgtgga gctgggaagc tttggggacc gggcagccat     1680

actagcagtg ggtgaagcaa gagacagtcc ctggtgcaac acaggaaatg ctggaatgcc     1740

ttttgcgtat tgttatagct gttgcaacct gggtcatttc ctctgcagct acactcatgg     1800

ttcagtttat actgcagcat gagcccaggg taattctggt acggcagtaa taaatattat     1860

actatttgca acat                                                       1874


<210>  6
<211>  352
<212>  PRT
<213>  mus musculus

<400>  6

Met Val Thr Pro Cys Pro Ala Ser Pro Gly Ser Pro Ala Ala Gly Ala 
1               5                   10                  15      


Gly Arg Arg Asp Ser His Gln Asn Leu Arg Ala Pro Val Lys Lys Ser 
            20                  25                  30          


Arg Arg Pro Cys Leu Arg Arg Lys Lys Pro Leu Arg Pro Leu Asn Ala 
        35                  40                  45              


Cys Ser Leu Pro Gly Asp Ser Gly Val Cys Asp Leu Phe Glu Ser Pro 
    50                  55                  60                  


Ser Ser Ser Ser Asp Gly Ala Asp Ser Pro Ala Val Ser Ala Ala Arg 
65                  70                  75                  80  


Asp Cys Ser Ser Leu Leu Asn Pro Ala Gln Pro Leu Thr Ala Leu Asp 
                85                  90                  95      


Leu Gln Thr Phe Arg Glu Tyr Gly Gln Ser Cys Tyr Asp Phe Arg Lys 
            100                 105                 110         


Ala Gln Glu Asn Leu Phe His Pro Arg Glu Ser Leu Ala Arg Gln Pro 
        115                 120                 125             


Gln Val Thr Ala Glu Ser Arg Cys Lys Leu Leu Ser Trp Leu Leu Gln 
    130                 135                 140                 


Val His Arg Gln Phe Gly Leu Ser Phe Glu Ser Leu Cys Leu Thr Val 
145                 150                 155                 160 


Asn Thr Leu Asp Arg Phe Leu Leu Thr Thr Pro Val Ala Ala Asp Cys 
                165                 170                 175     


Phe Gln Leu Leu Gly Val Thr Cys Leu Leu Ile Ala Cys Lys Gln Val 
            180                 185                 190         


Glu Val His Pro Pro Arg Leu Lys Gln Leu Leu Ala Leu Cys Gly Gly 
        195                 200                 205             


Ala Phe Ser Arg Gln Gln Leu Cys Asn Leu Glu Cys Ile Val Leu His 
    210                 215                 220                 


Lys Leu His Phe Ser Leu Gly Ala Pro Thr Ile Asn Phe Phe Leu Glu 
225                 230                 235                 240 


His Phe Thr Gln Trp Arg Met Glu Ala Gly Gln Ala Glu Val Thr Glu 
                245                 250                 255     


Ala Leu Glu Ala Gln Thr Leu Ala Arg Gly Val Ala Glu Leu Ser Leu 
            260                 265                 270         


Thr Asp Tyr Ala Phe Thr Thr Tyr Thr Pro Ser Leu Met Ala Ile Cys 
        275                 280                 285             


Cys Leu Ala Leu Ala Asp Gly Leu Leu Gln His Gln His Glu Met Asp 
    290                 295                 300                 


Leu Arg Leu Gly Glu His Pro Glu Ala Thr Leu Gln Asp Cys Leu Gly 
305                 310                 315                 320 


Lys Leu Gln Thr Leu Val Ser Ile Asn Ser Ser Ser Leu Pro Arg Ile 
                325                 330                 335     


Leu Pro Pro Gln Ile Trp Glu Arg Cys Ser Leu Pro Gln Ser Trp Gln 
            340                 345                 350         


<210>  7
<211>  1688
<212>  DNA
<213>  mus musculus

<400>  7
agagctgcgc cgccagcggg accggatctt cctcgcagct ctcgcgccga cgctccgggc       60

gtcgtagacg ctaggagcgc tacccgattg taacatggtt accccttgcc ctgccagccc      120

gggcagcccc gccgcgggag ccgggaggcg agacagccac cagaacctcc gcgccccagt      180

gaagaagagc agacgcccgt gcctccggag aaagaagccg ctgcggccgc tgaacgcgtg      240

ttcgctcccg ggagactcgg gcgtctgtga ccttttcgag tcccccagct ccagctcgga      300

cggcgccgac agccccgcag tgtctgcggc gcgggactgc agctccctac tcaaccctgc      360

ccagcccttg acagcgctgg atctccagac cttccgagaa tacggccaga gctgctacga      420

cttccgaaag gcgcaggaga atcttttcca cccgcgggag tcgctggcgc gccagccaca      480

agtagaggtg cacccacctc gcttgaaaca gctcctggcc ctgtgcggcg gtgcgttctc      540

ccggcagcag ctgtgcaacc tggagtgcat cgtgctgcat aagctccact tcagcctggg      600

cgcgcccacc atcaacttct tcctggagca cttcactcag tggcgcatgg aagccggcca      660

ggctgaggtc accgaagctc tagaggctca aaccctggcc cggggagtgg cggagctgag      720

cctaacggat tacgcgttca ctacctacac gccgtccctg atggctatct gctgcctggc      780

gctggctgac ggattgctgc agcaccagca cgagatggac ctgcgcctgg gagagcaccc      840

agaggccaca ctgcaagact gtctgggcaa gctgcagacg ctagtgtcca tcaatagcag      900

ctccctgcct cgcattctgc ctccccagat ctgggagagg tgcagcctgc cccagagttg      960

gcaataaaaa gcaccccctt gagctccttt ttaaaattcc ctggtccctg ctccgtgcct     1020

taaggagaat atgcagtaca gatccaaaga gaagttgagg tctcctacct gtaaatactg     1080

tacaataacg gattctttat ttattttgta gtacacaagg gcaggggtga cagttctggc     1140

ttgtctaaat gctgctgttg gcatgcctga ctgtctgctt ttcccaggcg aagtccatca     1200

cgaggtagcc aattccggag gctcttccct gctcccacag ttttactttg tagttagctc     1260

tgtgaaaaca acctggcaag attttatatg ccactgttcc agaaagcaga caagtcaagg     1320

tggcttgtcc gtatcttaac cccctccagt caggaggctg agttccctcc cccatgccag     1380

tggcccaagg agaatgagac agggttagaa gtcagagtgg tctgtgctgt ccggaaaggc     1440

agtggctgca ctaactgatg tggagctggg aagctttggg gaccgggcag ccatactagc     1500

agtgggtgaa gcaagagaca gtccctggtg caacacagga aatgctggaa tgccttttgc     1560

gtattgttat agctgttgca acctgggtca tttcctctgc agctacactc atggttcagt     1620

ttatactgca gcatgagccc agggtaattc tggtacggca gtaataaata ttatactatt     1680

tgcaacat                                                              1688


<210>  8
<211>  290
<212>  PRT
<213>  mus musculus

<400>  8

Met Val Thr Pro Cys Pro Ala Ser Pro Gly Ser Pro Ala Ala Gly Ala 
1               5                   10                  15      


Gly Arg Arg Asp Ser His Gln Asn Leu Arg Ala Pro Val Lys Lys Ser 
            20                  25                  30          


Arg Arg Pro Cys Leu Arg Arg Lys Lys Pro Leu Arg Pro Leu Asn Ala 
        35                  40                  45              


Cys Ser Leu Pro Gly Asp Ser Gly Val Cys Asp Leu Phe Glu Ser Pro 
    50                  55                  60                  


Ser Ser Ser Ser Asp Gly Ala Asp Ser Pro Ala Val Ser Ala Ala Arg 
65                  70                  75                  80  


Asp Cys Ser Ser Leu Leu Asn Pro Ala Gln Pro Leu Thr Ala Leu Asp 
                85                  90                  95      


Leu Gln Thr Phe Arg Glu Tyr Gly Gln Ser Cys Tyr Asp Phe Arg Lys 
            100                 105                 110         


Ala Gln Glu Asn Leu Phe His Pro Arg Glu Ser Leu Ala Arg Gln Pro 
        115                 120                 125             


Gln Val Glu Val His Pro Pro Arg Leu Lys Gln Leu Leu Ala Leu Cys 
    130                 135                 140                 


Gly Gly Ala Phe Ser Arg Gln Gln Leu Cys Asn Leu Glu Cys Ile Val 
145                 150                 155                 160 


Leu His Lys Leu His Phe Ser Leu Gly Ala Pro Thr Ile Asn Phe Phe 
                165                 170                 175     


Leu Glu His Phe Thr Gln Trp Arg Met Glu Ala Gly Gln Ala Glu Val 
            180                 185                 190         


Thr Glu Ala Leu Glu Ala Gln Thr Leu Ala Arg Gly Val Ala Glu Leu 
        195                 200                 205             


Ser Leu Thr Asp Tyr Ala Phe Thr Thr Tyr Thr Pro Ser Leu Met Ala 
    210                 215                 220                 


Ile Cys Cys Leu Ala Leu Ala Asp Gly Leu Leu Gln His Gln His Glu 
225                 230                 235                 240 


Met Asp Leu Arg Leu Gly Glu His Pro Glu Ala Thr Leu Gln Asp Cys 
                245                 250                 255     


Leu Gly Lys Leu Gln Thr Leu Val Ser Ile Asn Ser Ser Ser Leu Pro 
            260                 265                 270         


Arg Ile Leu Pro Pro Gln Ile Trp Glu Arg Cys Ser Leu Pro Gln Ser 
        275                 280                 285             


Trp Gln 
    290 


<210>  9
<211>  1874
<212>  DNA
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: Nucleotide sequence 
       encoding murine Cylin O-alpha L3A mutant"

<400>  9
agagctgcgc cgccagcggg accggatctt cctcgcagct ctcgcgccga cgctccgggc       60

gtcgtagacg ctaggagcgc tacccgattg taacatggtt accccttgcc ctgccagccc      120

gggcagcccc gccgcgggag ccgggaggcg agacagccac cagaacctcc gcgccccagt      180

gaagaagagc agacgcccgt gcctccggag aaagaagccg ctgcggccgc tgaacgcgtg      240

ttcgctcccg ggagactcgg gcgtctgtga ccttttcgag tcccccagct ccagctcgga      300

cggcgccgac agccccgcag tgtctgcggc gcgggactgc agctccctac tcaaccctgc      360

ccagcccgcg acagcggcgg atgcccagac cttccgagaa tacggccaga gctgctacga      420

cttccgaaag gcgcaggaga atcttttcca cccgcgggag tcgctggcgc gccagccaca      480

agtgactgcc gaatcgcgct gtaaactgct cagctggctc ctgcaagtcc accgccagtt      540

cggcctctct ttcgagtcgc tgtgtctgac cgtgaatact ctggaccgtt ttctcctcac      600

gacccctgtt gctgcagact gcttccagct gctcggggtc acctgtctgc tcatcgcttg      660

caagcaggta gaggtgcacc cacctcgctt gaaacagctc ctggccctgt gcggcggtgc      720

gttctcccgg cagcagctgt gcaacctgga gtgcatcgtg ctgcataagc tccacttcag      780

cctgggcgcg cccaccatca acttcttcct ggagcacttc actcagtggc gcatggaagc      840

cggccaggct gaggtcaccg aagctctaga ggctcaaacc ctggcccggg gagtggcgga      900

gctgagccta acggattacg cgttcactac ctacacgccg tccctgatgg ctatctgctg      960

cctggcgctg gctgacggat tgctgcagca ccagcacgag atggacctgc gcctgggaga     1020

gcacccagag gccacactgc aagactgtct gggcaagctg cagacgctag tgtccatcaa     1080

tagcagctcc ctgcctcgca ttctgcctcc ccagatctgg gagaggtgca gcctgcccca     1140

gagttggcaa taaaaagcac ccccttgagc tcctttttaa aattccctgg tccctgctcc     1200

gtgccttaag gagaatatgc agtacagatc caaagagaag ttgaggtctc ctacctgtaa     1260

atactgtaca ataacggatt ctttatttat tttgtagtac acaagggcag gggtgacagt     1320

tctggcttgt ctaaatgctg ctgttggcat gcctgactgt ctgcttttcc caggcgaagt     1380

ccatcacgag gtagccaatt ccggaggctc ttccctgctc ccacagtttt actttgtagt     1440

tagctctgtg aaaacaacct ggcaagattt tatatgccac tgttccagaa agcagacaag     1500

tcaaggtggc ttgtccgtat cttaaccccc tccagtcagg aggctgagtt ccctccccca     1560

tgccagtggc ccaaggagaa tgagacaggg ttagaagtca gagtggtctg tgctgtccgg     1620

aaaggcagtg gctgcactaa ctgatgtgga gctgggaagc tttggggacc gggcagccat     1680

actagcagtg ggtgaagcaa gagacagtcc ctggtgcaac acaggaaatg ctggaatgcc     1740

ttttgcgtat tgttatagct gttgcaacct gggtcatttc ctctgcagct acactcatgg     1800

ttcagtttat actgcagcat gagcccaggg taattctggt acggcagtaa taaatattat     1860

actatttgca acat                                                       1874


<210>  10
<211>  352
<212>  PRT
<213>  artificial sequence

<220>
<223>  /note="Description of artificial sequence: Amino acid sequence of
       murine Cyclin O-alpha L3A mutant"

<400>  10

Met Val Thr Pro Cys Pro Ala Ser Pro Gly Ser Pro Ala Ala Gly Ala 
1               5                   10                  15      


Gly Arg Arg Asp Ser His Gln Asn Leu Arg Ala Pro Val Lys Lys Ser 
            20                  25                  30          


Arg Arg Pro Cys Leu Arg Arg Lys Lys Pro Leu Arg Pro Leu Asn Ala 
        35                  40                  45              


Cys Ser Leu Pro Gly Asp Ser Gly Val Cys Asp Leu Phe Glu Ser Pro 
    50                  55                  60                  


Ser Ser Ser Ser Asp Gly Ala Asp Ser Pro Ala Val Ser Ala Ala Arg 
65                  70                  75                  80  


Asp Cys Ser Ser Leu Leu Asn Pro Ala Gln Pro Ala Thr Ala Ala Asp 
                85                  90                  95      


Ala Gln Thr Phe Arg Glu Tyr Gly Gln Ser Cys Tyr Asp Phe Arg Lys 
            100                 105                 110         


Ala Gln Glu Asn Leu Phe His Pro Arg Glu Ser Leu Ala Arg Gln Pro 
        115                 120                 125             


Gln Val Thr Ala Glu Ser Arg Cys Lys Leu Leu Ser Trp Leu Leu Gln 
    130                 135                 140                 


Val His Arg Gln Phe Gly Leu Ser Phe Glu Ser Leu Cys Leu Thr Val 
145                 150                 155                 160 


Asn Thr Leu Asp Arg Phe Leu Leu Thr Thr Pro Val Ala Ala Asp Cys 
                165                 170                 175     


Phe Gln Leu Leu Gly Val Thr Cys Leu Leu Ile Ala Cys Lys Gln Val 
            180                 185                 190         


Glu Val His Pro Pro Arg Leu Lys Gln Leu Leu Ala Leu Cys Gly Gly 
        195                 200                 205             


Ala Phe Ser Arg Gln Gln Leu Cys Asn Leu Glu Cys Ile Val Leu His 
    210                 215                 220                 


Lys Leu His Phe Ser Leu Gly Ala Pro Thr Ile Asn Phe Phe Leu Glu 
225                 230                 235                 240 


His Phe Thr Gln Trp Arg Met Glu Ala Gly Gln Ala Glu Val Thr Glu 
                245                 250                 255     


Ala Leu Glu Ala Gln Thr Leu Ala Arg Gly Val Ala Glu Leu Ser Leu 
            260                 265                 270         


Thr Asp Tyr Ala Phe Thr Thr Tyr Thr Pro Ser Leu Met Ala Ile Cys 
        275                 280                 285             


Cys Leu Ala Leu Ala Asp Gly Leu Leu Gln His Gln His Glu Met Asp 
    290                 295                 300                 


Leu Arg Leu Gly Glu His Pro Glu Ala Thr Leu Gln Asp Cys Leu Gly 
305                 310                 315                 320 


Lys Leu Gln Thr Leu Val Ser Ile Asn Ser Ser Ser Leu Pro Arg Ile 
                325                 330                 335     


Leu Pro Pro Gln Ile Trp Glu Arg Cys Ser Leu Pro Gln Ser Trp Gln 
            340                 345                 350         


<210>  11
<211>  1338
<212>  DNA
<213>  Homo sapiens

<400>  11
caccggcctc attttacaga tggagaaaag tggggcgtag acggcttgag ggacttgccc       60

cgtcccaagc tggctactgg ggcacggtag agaggaattc gtttccgggt tgagtctgga      120

ctcctaccga actcgggcaa gttatttaac acccctgagc ttctttcttc atctgcaaaa      180

tggaacccct ccccttcctt tgaattgctg agcccattac gcgaggtaat gtgtacgacg      240

ctctctgcac agcgccaggt cccaatcccg gtgttccggc tcagcacggc ccacgcgttt      300

cccagtttcc attgcgtttc tctttctgaa atcttcttgc ccctctcctg ggaagctccc      360

cgattcttct tggcccttcc ttcccttcca cagtccctct ccaccctaag cccagcgggc      420

ccgcctcccc cctccttccc ggcaggtgac ggcggaatcc cgctgtaagc tgctcagctg      480

gctgatcccg gtgcaccgcc aattcggcct ctccttcgag tcgctgtgcc tgacggtgaa      540

cactctggac cgcttcctca ccaccacgcc ggtggctgca gactgcttcc agctgcttgg      600

ggtcacctcc ttgctcatcg cttgcaaaca ggtggaggtg cacccgccgc gcgtgaagca      660

gcttctggcc ctctgctgcg gcgccttctc ccggcagcag ctctgcaacc tcgagtgcat      720

cgtgctgcac aagctgcact tcaccctggg tgcgcccacc attagcttct tcctggagca      780

tttcacgcac gctcgcgtgg aggcggggca ggctgaggcc tccgaagctc tggaagcgca      840

agccctggcg cggggggtgg cagagctgag tctggccgac tatgccttca ccagctactc      900

cccttccctc ctggcgatct gctgcctggc gctggcggac cgcatgctgc gggtctcgcg      960

gcccgtggac ttgcgactgg gagaccaccc ggaggcggcg ctggaggact gtatgggcaa     1020

gttgcagctg ctggtggcca taaacagtac ttccttgact cacatgctgc ccgttcagat     1080

ctgcgagaag tgcagcctgc ccccgagctc gaaataaaac agatccttcg tttcctttta     1140

gtccctggcc cggctgctgg acctctcccg tagcctcaga agagtgcagt actggtccac     1200

agagaaggct tcaggacctg cttggtcagc tgcaggttgt aaatagtgta cgatactagc     1260

atctggtatt ttatttattt tgcagcgagc acatgaggaa gctgagtctt tcaccaataa     1320

acagttgtgg tttgtcta                                                   1338


<210>  12
<211>  567
<212>  DNA
<213>  mus musculus

<400>  12
ttgtgcgacg gtcatttgaa gtaacttctt acgtttttgg atcacaaata cctgtctgac       60

aggacgggct cccacatact taacagacgt tagcgacgcg ccaaagttct ccttccctgg      120

gccagcggaa tgaaataaaa tagtcgcaaa tcaagtcctt ttatgggtca ctgaagaaaa      180

cctagcctga tcttggtccg gagctcagag gcggacccac ctggatgagg gttggcataa      240

aagatgatca caccaggcca gacaatctaa ccaaggacca ggttccccgg agcagccttt      300

ccctttttcc gggggcggct gaaccgctca gacggcccat ggctccccta ggtggccagt      360

gatctttacg ctcttccacc gagctcaagc agctggcgcc aggacccggg ctgcggttgc      420

cacggtgacg acagacgcgc ggagcctgca gctgaaggcg gcccgggcag ccccgccgcg      480

ggagccggga ggcgagacag ccaccagaac ctccgcgccc cagtgaagaa gagcagacgc      540

ccgtgcctcc ggagaaagaa gccgctg                                          567


<210>  13
<211>  1531
<212>  DNA
<213>  Homo sapiens

<400>  13
ctccccccgg cgggccgcgg aggcgacgcg ctgcctgcgc cctgaggcga gtggttctcc       60

agccggaaaa tcgcggctcc ggtgccgctc tgggctcagc cagtgagagg ccgggggtgt      120

ggtagagaga aggagccggc cgggtactta ggaccgcgcc agcctctgag cccggcctcc      180

ttcgcacttt cgagtgcgcg tttgctgccc gccgcagccc gggcgttgaa ggtagtaaag      240

cggccacccg gccgcatcat ggtgaccccc tgtcccacca gcccctcgag ccccgccgcc      300

cgagcgggga ggcgggacaa cgaccagaac cttcgcgccc cggtgaagaa gagcaggcgt      360

ccgcgcctcc ggaggaagca gccgctgcat cccctgaacc cgtgcccgct cccgggagac      420

tccggcattt gcgacctgtt cgagtccccc agctccggct cagacggcgc agagagcccc      480

tctgcggcgc ggggtggtag ccccctgccc ggcccggccc agcccgcggc gcaggcagat      540

gcacagacct tccgcgacta cggccagagc tgctacgcct tccgcaaggc gcaggagagc      600

cacttccacc cgcgggaggc gctggcacgg cagccacaag tgacggcgga atcccgctgt      660

aagctgctca gctggctgat cccggtgcac cgccaattcg gcctctcctt cgagtcgctg      720

tgcctgacgg tgaacactct ggaccgcttc ctcaccacca cgccggtggc tgcagactgc      780

ttccagctgc ttggggtcac ctccttgctc atcgcttgca aacaggtgga ggtgcacccg      840

ccgcgcgtga agcagcttct ggccctctgc tgcggcgcct tctcccggca gcagctctgc      900

aacctcgagt gcatcgtgct gcacaagctg cacttcaccc tgggtgcgcc caccattagc      960

ttcttcctgg agcatttcac gcacgctcgc gtggaggcgg ggcaggctga ggcctccgaa     1020

gctctggaag cgcaagccct ggcgcggggg gtggcagagc tgagtctggc cgactatgcc     1080

ttcaccagct actccccttc cctcctggcg atctgctgcc tggcgctggc ggaccgcatg     1140

ctgcgggtct cgcggcccgt ggacttgcga ctgggagacc acccggaggc ggcgctggag     1200

gactgtatgg gcaagttgca gctgctggtg gccataaaca gtacttcctt gactcacatg     1260

ctgcccgttc agatctgcga gaagtgcagc ctgcccccga gctcgaaata aaacagatcc     1320

ttcgtttcct tttagtccct ggcccggctg ctggacctct cccgtagcct cagaagagtg     1380

cagtactggt ccacagagaa ggcttcagga cctgcttggt cagctgcagg ttgtaaatag     1440

tgtacgatac tagcatctgg tattttattt attttgcagc gagcacatga ggaagctgag     1500

tctttcacca ataaacagtt gtggtttgtc t                                    1531


<210>  14
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Val Thr Pro Cys Pro Thr Ser Pro Ser Ser Pro Ala Ala Arg Ala 
1               5                   10                  15      


Gly Arg Arg Asp Asn Asp Gln Asn Leu Arg Ala Pro Val Lys Lys Ser 
            20                  25                  30          


Arg Arg Pro Arg Leu Arg Arg Lys Gln Pro Leu His Pro Leu Asn Pro 
        35                  40                  45              


Cys Pro Leu Pro Gly Asp Ser Gly Ile Cys Asp Leu Phe Glu Ser Pro 
    50                  55                  60                  


Ser Ser Gly Ser Asp Gly Ala Glu Ser Pro Ser Ala Ala Arg Gly Gly 
65                  70                  75                  80  


Ser Pro Leu Pro Gly Pro Ala Gln Pro Ala Ala Gln Ala Asp Ala Gln 
                85                  90                  95      


Thr Phe Arg Asp Tyr Gly Gln Ser Cys Tyr Ala Phe Arg Lys Ala Gln 
            100                 105                 110         


Glu Ser His Phe His Pro Arg Glu Ala Leu Ala Arg Gln Pro Gln Val 
        115                 120                 125             


Thr Ala Glu Ser Arg Cys Lys Leu Leu Ser Trp Leu Ile Pro Val His 
    130                 135                 140                 


Arg Gln Phe Gly Leu Ser Phe Glu Ser Leu Cys Leu Thr Val Asn Thr 
145                 150                 155                 160 


Leu Asp Arg Phe Leu Thr Thr Thr Pro Val Ala Ala Asp Cys Phe Gln 
                165                 170                 175     


Leu Leu Gly Val Thr Ser Leu Leu Ile Ala Cys Lys Gln Val Glu Val 
            180                 185                 190         


His Pro Pro Arg Val Lys Gln Leu Leu Ala Leu Cys Cys Gly Ala Phe 
        195                 200                 205             


Ser Arg Gln Gln Leu Cys Asn Leu Glu Cys Ile Val Leu His Lys Leu 
    210                 215                 220                 


His Phe Thr Leu Gly Ala Pro Thr Ile Ser Phe Phe Leu Glu His Phe 
225                 230                 235                 240 


Thr His Ala Arg Val Gly Ala Gly Gln Ala Glu Ala Ser Glu Ala Leu 
                245                 250                 255     


Glu Ala Gln Ala Leu Ala Arg Gly Val Ala Glu Leu Ser Leu Ala Asp 
            260                 265                 270         


Tyr Ala Phe Thr Ser Tyr Ser Pro Ser Leu Leu Ala Ile Cys Cys Leu 
        275                 280                 285             


Ala Leu Ala Asp Arg Met Leu Arg Val Ser Arg Pro Val Asp Leu Arg 
    290                 295                 300                 


Leu Gly Asp His Pro Glu Ala Ala Leu Glu Asp Cys Met Gly Lys Leu 
305                 310                 315                 320 


Gln Leu Leu Val Ala Ile Asn Ser Thr Ser Leu Thr His Met Leu Pro 
                325                 330                 335     


Val Gln Ile Cys Glu Lys Cys Ser Leu Pro Pro Ser Ser Lys 
            340                 345                 350 


