                         SEQUENCE LISTING

<110>  Minerva Biotechnologies Corporation
       Bamdad, Cynthia
       Fessler, Shawn
 
<120>  METHOD FOR INDUCING PLURIPOTENCY IN CELLS

<130>  13150-70099USA

<150>  61/104,231
<151>  2008-10-09

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  1255
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His 
    50                  55                  60                  


Ser Pro Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu 
65                  70                  75                  80  


Ala Pro Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln 
                85                  90                  95      


Asp Val Thr Ser Val Pro Val Thr Arg Pro Ala Leu Gly Ser Thr Thr 
            100                 105                 110         


Pro Pro Ala His Asp Val Thr Ser Ala Pro Asp Asn Lys Pro Ala Pro 
        115                 120                 125             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    130                 135                 140                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
145                 150                 155                 160 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                165                 170                 175     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            180                 185                 190         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        195                 200                 205             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    210                 215                 220                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
225                 230                 235                 240 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                245                 250                 255     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            260                 265                 270         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        275                 280                 285             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    290                 295                 300                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
305                 310                 315                 320 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                325                 330                 335     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            340                 345                 350         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        355                 360                 365             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    370                 375                 380                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
385                 390                 395                 400 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                405                 410                 415     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            420                 425                 430         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        435                 440                 445             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    450                 455                 460                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
465                 470                 475                 480 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                485                 490                 495     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            500                 505                 510         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        515                 520                 525             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    530                 535                 540                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
545                 550                 555                 560 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                565                 570                 575     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            580                 585                 590         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        595                 600                 605             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    610                 615                 620                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
625                 630                 635                 640 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                645                 650                 655     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            660                 665                 670         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        675                 680                 685             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    690                 695                 700                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
705                 710                 715                 720 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                725                 730                 735     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            740                 745                 750         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        755                 760                 765             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    770                 775                 780                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
785                 790                 795                 800 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                805                 810                 815     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            820                 825                 830         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        835                 840                 845             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    850                 855                 860                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
865                 870                 875                 880 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                885                 890                 895     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            900                 905                 910         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        915                 920                 925             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Asn 
    930                 935                 940                 


Arg Pro Ala Leu Gly Ser Thr Ala Pro Pro Val His Asn Val Thr Ser 
945                 950                 955                 960 


Ala Ser Gly Ser Ala Ser Gly Ser Ala Ser Thr Leu Val His Asn Gly 
                965                 970                 975     


Thr Ser Ala Arg Ala Thr Thr Thr Pro Ala Ser Lys Ser Thr Pro Phe 
            980                 985                 990         


Ser Ile Pro Ser His His Ser Asp  Thr Pro Thr Thr Leu  Ala Ser His 
        995                 1000                 1005             


Ser Thr  Lys Thr Asp Ala Ser  Ser Thr His His Ser  Ser Val Pro 
    1010                 1015                 1020             


Pro Leu  Thr Ser Ser Asn His  Ser Thr Ser Pro Gln  Leu Ser Thr 
    1025                 1030                 1035             


Gly Val  Ser Phe Phe Phe Leu  Ser Phe His Ile Ser  Asn Leu Gln 
    1040                 1045                 1050             


Phe Asn  Ser Ser Leu Glu Asp  Pro Ser Thr Asp Tyr  Tyr Gln Glu 
    1055                 1060                 1065             


Leu Gln  Arg Asp Ile Ser Glu  Met Phe Leu Gln Ile  Tyr Lys Gln 
    1070                 1075                 1080             


Gly Gly  Phe Leu Gly Leu Ser  Asn Ile Lys Phe Arg  Pro Gly Ser 
    1085                 1090                 1095             


Val Val  Val Gln Leu Thr Leu  Ala Phe Arg Glu Gly  Thr Ile Asn 
    1100                 1105                 1110             


Val His  Asp Val Glu Thr Gln  Phe Asn Gln Tyr Lys  Thr Glu Ala 
    1115                 1120                 1125             


Ala Ser  Arg Tyr Asn Leu Thr  Ile Ser Asp Val Ser  Val Ser Asp 
    1130                 1135                 1140             


Val Pro  Phe Pro Phe Ser Ala  Gln Ser Gly Ala Gly  Val Pro Gly 
    1145                 1150                 1155             


Trp Gly  Ile Ala Leu Leu Val  Leu Val Cys Val Leu  Val Ala Leu 
    1160                 1165                 1170             


Ala Ile  Val Tyr Leu Ile Ala  Leu Ala Val Cys Gln  Cys Arg Arg 
    1175                 1180                 1185             


Lys Asn  Tyr Gly Gln Leu Asp  Ile Phe Pro Ala Arg  Asp Thr Tyr 
    1190                 1195                 1200             


His Pro  Met Ser Glu Tyr Pro  Thr Tyr His Thr His  Gly Arg Tyr 
    1205                 1210                 1215             


Val Pro  Pro Ser Ser Thr Asp  Arg Ser Pro Tyr Glu  Lys Val Ser 
    1220                 1225                 1230             


Ala Gly  Asn Gly Gly Ser Ser  Leu Ser Tyr Thr Asn  Pro Ala Val 
    1235                 1240                 1245             


Ala Ala  Ala Ser Ala Asn Leu  
    1250                 1255 


<210>  2
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr 
            


<210>  3
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Ala 
            20              


<210>  4
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly 
            20              


<210>  5
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  5

Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys 
1               5                   10                  15      


Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val 
            20                  25                  30          


Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro 
        35                  40                  45              


Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu 
    50                  55                  60                  


Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys 
65                  70                  75                  80  


Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro 
                85                  90                  95      


Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro 
            100                 105                 110         


Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly 
        115                 120                 125             


Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Ala Ser Ala 
    130                 135                 140                 


Asn Leu 
145     


<210>  6
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  6

Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys 
1               5                   10                  15      


Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val 
            20                  25                  30          


Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala 
        35                  40                  45  


<210>  7
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  7

Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 
1               5                   10                  15      


Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser 
            20                  25                  30          


Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala 
        35                  40                  


<210>  8
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  8

Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys 
1               5                   10                  15      


Thr Glu Ala Ala Ser Pro Tyr Asn Leu Thr Ile Ser Asp Val Ser Val 
            20                  25                  30          


Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala 
        35                  40                  45  


<210>  9
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  9

Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 
1               5                   10                  15      


Glu Ala Ala Ser Pro Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser 
            20                  25                  30          


Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala 
        35                  40                  


<210>  10
<211>  216
<212>  DNA
<213>  Homo sapiens

<400>  10
tgtcagtgcc gccgaaagaa ctacgggcag ctggacatct ttccagcccg ggatacctac       60

catcctatga gcgagtaccc cacctaccac acccatgggc gctatgtgcc ccctagcagt      120

accgatcgta gcccctatga gaaggtttct gcaggtaacg gtggcagcag cctctcttac      180

acaaacccag cagtggcagc cgcttctgcc aacttg                                216


<210>  11
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  11

Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala 
1               5                   10                  15      


Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His 
            20                  25                  30          


Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys 
        35                  40                  45              


Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala 
    50                  55                  60                  


Val Ala Ala Ala Ser Ala Asn Leu 
65                  70          


<210>  12
<211>  854
<212>  DNA
<213>  Homo sapiens

<400>  12
gagatcctga gacaatgaat catagtgaaa gattcgtttt cattgcagag tggtatgatc       60

caaatgcttc acttcttcga cgttatgagc ttttatttta cccaggggat ggatctgttg      120

aaatgcatga tgtaaagaat catcgcacct ttttaaagcg gaccaaatat gataacctgc      180

acttggaaga tttatttata ggcaacaaag tgaatgtctt ttctcgacaa ctggtattaa      240

ttgactatgg ggatcaatat acagctcgcc agctgggcag taggaaagaa aaaacgctag      300

ccctaattaa accagatgca atatcaaagg ctggagaaat aattgaaata ataaacaaag      360

ctggatttac tataaccaaa ctcaaaatga tgatgctttc aaggaaagaa gcattggatt      420

ttcatgtaga tcaccagtca agaccctttt tcaatgagct gatccagttt attacaactg      480

gtcctattat tgccatggag attttaagag atgatgctat atgtgaatgg aaaagactgc      540

tgggacctgc aaactctgga gtggcacgca cagatgcttc tgaaagcatt agagccctct      600

ttggaacaga tggcataaga aatgcagcgc atggccctga ttcttttgct tctgcggcca      660

gagaaatgga gttgtttttt ccttcaagtg gaggttgtgg gccggcaaac actgctaaat      720

ttactaattg tacctgttgc attgttaaac cccatgctgt cagtgaaggt atgttgaata      780

cactatattc agtacatttt gttaatagga gagcaatgtt tattttcttg atgtacttta      840

tgtatagaaa ataa                                                        854


<210>  13
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  13

Asp Pro Glu Thr Met Asn His Ser Glu Arg Phe Val Phe Ile Ala Glu 
1               5                   10                  15      


Trp Tyr Asp Pro Asn Ala Ser Leu Leu Arg Arg Tyr Glu Leu Leu Phe 
            20                  25                  30          


Tyr Pro Gly Asp Gly Ser Val Glu Met His Asp Val Lys Asn His Arg 
        35                  40                  45              


Thr Phe Leu Lys Arg Thr Lys Tyr Asp Asn Leu His Leu Glu Asp Leu 
    50                  55                  60                  


Phe Ile Gly Asn Lys Val Asn Val Phe Ser Arg Gln Leu Val Leu Ile 
65                  70                  75                  80  


Asp Tyr Gly Asp Gln Tyr Thr Ala Arg Gln Leu Gly Ser Arg Lys Glu 
                85                  90                  95      


Lys Thr Leu Ala Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala Gly Glu 
            100                 105                 110         


Ile Ile Glu Ile Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys Leu Lys 
        115                 120                 125             


Met Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp His 
    130                 135                 140                 


Gln Ser Arg Pro Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr Gly 
145                 150                 155                 160 


Pro Ile Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu Trp 
                165                 170                 175     


Lys Arg Leu Leu Gly Pro Ala Asn Ser Gly Val Ala Arg Thr Asp Ala 
            180                 185                 190         


Ser Glu Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg Asn Ala 
        195                 200                 205             


Ala His Gly Pro Asp Ser Phe Ala Ser Ala Ala Arg Glu Met Glu Leu 
    210                 215                 220                 


Phe Phe Pro Ser Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala Lys Phe 
225                 230                 235                 240 


Thr Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly 
                245                 250                 255     


Met Leu Asn Thr Leu Tyr Ser Val His Phe Val Asn Arg Arg Ala Met 
            260                 265                 270         


Phe Ile Phe Leu Met Tyr Phe Met Tyr Arg Lys 
        275                 280             


<210>  14
<211>  534
<212>  DNA
<213>  Homo sapiens

<400>  14
atggtgctac tgtctacttt agggatcgtc tttcaaggcg aggggcctcc tatctcaagc       60

tgtgatacag gaaccatggc caactgtgag cgtaccttca ttgcgatcaa accagatggg      120

gtccagcggg gtcttgtggg agagattatc aagcgttttg agcagaaagg attccgcctt      180

gttggtctga aattcatgca agcttccgaa gatcttctca aggaacacta cgttgacctg      240

aaggaccgtc cattctttgc cggcctggtg aaatacatgc actcagggcc ggtagttgcc      300

atggtctggg aggggctgaa tgtggtgaag acgggccgag tcatgctcgg ggagaccaac      360

cctgcagact ccaagcctgg gaccatccgt ggagacttct gcatacaagt tggcaggaac      420

attatacatg gcagtgattc tgtggagagt gcagagaagg agatcggctt gtggtttcac      480

cctgaggaac tggtagatta cacgagctgt gctcagaact ggatctatga atga            534


<210>  15
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Val Leu Leu Ser Thr Leu Gly Ile Val Phe Gln Gly Glu Gly Pro 
1               5                   10                  15      


Pro Ile Ser Ser Cys Asp Thr Gly Thr Met Ala Asn Cys Glu Arg Thr 
            20                  25                  30          


Phe Ile Ala Ile Lys Pro Asp Gly Val Gln Arg Gly Leu Val Gly Glu 
        35                  40                  45              


Ile Ile Lys Arg Phe Glu Gln Lys Gly Phe Arg Leu Val Gly Leu Lys 
    50                  55                  60                  


Phe Met Gln Ala Ser Glu Asp Leu Leu Lys Glu His Tyr Val Asp Leu 
65                  70                  75                  80  


Lys Asp Arg Pro Phe Phe Ala Gly Leu Val Lys Tyr Met His Ser Gly 
                85                  90                  95      


Pro Val Val Ala Met Val Trp Glu Gly Leu Asn Val Val Lys Thr Gly 
            100                 105                 110         


Arg Val Met Leu Gly Glu Thr Asn Pro Ala Asp Ser Lys Pro Gly Thr 
        115                 120                 125             


Ile Arg Gly Asp Phe Cys Ile Gln Val Gly Arg Asn Ile Ile His Gly 
    130                 135                 140                 


Ser Asp Ser Val Glu Ser Ala Glu Lys Glu Ile Gly Leu Trp Phe His 
145                 150                 155                 160 


Pro Glu Glu Leu Val Asp Tyr Thr Ser Cys Ala Gln Asn Trp Ile Tyr 
                165                 170                 175     


Glu 
    


<210>  16
<211>  534
<212>  DNA
<213>  Homo sapiens

<400>  16
atggtgctac tgtctacttt agggatcgtc tttcaaggcg aggggcctcc tatctcaagc       60

tgtgatacag gaaccatggc caactgtgag cgtaccttca ttgcgatcaa accagatggg      120

gtccagcggg gtcttgtggg agagattatc aagcgttttg agcagaaagg attccgcctt      180

gttggtctga aattcatgca agcttccgaa gatcttctca aggaacacta cgttgacctg      240

aaggaccgtc cattctttgc cggcctggtg aaatacatgc actcagggcc ggtagttgcc      300

atggtctggg aggggctgaa tgtggtgaag acgggccgag tcatgctcgg ggagaccaac      360

cctgcagact ccaagcctgg gaccatccgt ggagacttct gcatacaagt tggcaggaac      420

attatacatg gcggtgattc tgtggagagt gcagagaagg agatcggctt gtggtttcac      480

cctgaggaac tggtagatta cacgagctgt gctcagaact ggatctatga atga            534


<210>  17
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Val Leu Leu Ser Thr Leu Gly Ile Val Phe Gln Gly Glu Gly Pro 
1               5                   10                  15      


Pro Ile Ser Ser Cys Asp Thr Gly Thr Met Ala Asn Cys Glu Arg Thr 
            20                  25                  30          


Phe Ile Ala Ile Lys Pro Asp Gly Val Gln Arg Gly Leu Val Gly Glu 
        35                  40                  45              


Ile Ile Lys Arg Phe Glu Gln Lys Gly Phe Arg Leu Val Gly Leu Lys 
    50                  55                  60                  


Phe Met Gln Ala Ser Glu Asp Leu Leu Lys Glu His Tyr Val Asp Leu 
65                  70                  75                  80  


Lys Asp Arg Pro Phe Phe Ala Gly Leu Val Lys Tyr Met His Ser Gly 
                85                  90                  95      


Pro Val Val Ala Met Val Trp Glu Gly Leu Asn Val Val Lys Thr Gly 
            100                 105                 110         


Arg Val Met Leu Gly Glu Thr Asn Pro Ala Asp Ser Lys Pro Gly Thr 
        115                 120                 125             


Ile Arg Gly Asp Phe Cys Ile Gln Val Gly Arg Asn Ile Ile His Gly 
    130                 135                 140                 


Ser Asp Ser Val Glu Ser Ala Glu Lys Glu Ile Gly Leu Trp Phe His 
145                 150                 155                 160 


Pro Glu Glu Leu Val Asp Tyr Thr Ser Cys Ala Gln Asn Trp Ile Tyr 
                165                 170                 175     


Glu 
    


<210>  18
<211>  954
<212>  DNA
<213>  Homo sapiens

<400>  18
atgtacaaca tgatggagac ggagctgaag ccgccgggcc cgcagcaaac ttcggggggc       60

ggcggcggca actccaccgc ggcggcggcc ggcggcaacc agaaaaacag cccggaccgc      120

gtcaagcggc ccatgaatgc cttcatggtg tggtcccgcg ggcagcggcg caagatggcc      180

caggagaacc ccaagatgca caactcggag atcagcaagc gcctgggcgc cgagtggaaa      240

cttttgtcgg agacggagaa gcggccgttc atcgacgagg ctaagcggct gcgagcgctg      300

cacatgaagg agcacccgga ttataaatac cggccccggc ggaaaaccaa gacgctcatg      360

aagaaggata agtacacgct gcccggcggg ctgctggccc ccggcggcaa tagcatggcg      420

agcggggtcg gggtgggcgc cggcctgggc gcgggcgtga accagcgcat ggacagttac      480

gcgcacatga acggctggag caacggcagc tacagcatga tgcaggacca gctgggctac      540

ccgcagcacc cgggcctcaa tgcgcacggc gcagcgcaga tgcagcccat gcaccgctac      600

gacgtgagcg ccctgcagta caactccatg accagctcgc agacctacat gaacggctcg      660

cccacctaca gcatgtccta ctcgcagcag ggcacccctg gcatggctct tggctccatg      720

ggttcggtgg tcaagtccga ggccagctcc agcccccctg tggttacctc ttcctcccac      780

tccagggcgc cctgccaggc cggggacctc cgggacatga tcagcatgta tctccccggc      840

gccgaggtgc cggaacccgc cgcccccagc agacttcaca tgtcccagca ctaccagagc      900

ggcccggtgc ccggcacggc cattaacggc acactgcccc tctcacacat gtga            954


<210>  19
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Tyr Asn Met Met Glu Thr Glu Leu Lys Pro Pro Gly Pro Gln Gln 
1               5                   10                  15      


Thr Ser Gly Gly Gly Gly Gly Asn Ser Thr Ala Ala Ala Ala Gly Gly 
            20                  25                  30          


Asn Gln Lys Asn Ser Pro Asp Arg Val Lys Arg Pro Met Asn Ala Phe 
        35                  40                  45              


Met Val Trp Ser Arg Gly Gln Arg Arg Lys Met Ala Gln Glu Asn Pro 
    50                  55                  60                  


Lys Met His Asn Ser Glu Ile Ser Lys Arg Leu Gly Ala Glu Trp Lys 
65                  70                  75                  80  


Leu Leu Ser Glu Thr Glu Lys Arg Pro Phe Ile Asp Glu Ala Lys Arg 
                85                  90                  95      


Leu Arg Ala Leu His Met Lys Glu His Pro Asp Tyr Lys Tyr Arg Pro 
            100                 105                 110         


Arg Arg Lys Thr Lys Thr Leu Met Lys Lys Asp Lys Tyr Thr Leu Pro 
        115                 120                 125             


Gly Gly Leu Leu Ala Pro Gly Gly Asn Ser Met Ala Ser Gly Val Gly 
    130                 135                 140                 


Val Gly Ala Gly Leu Gly Ala Gly Val Asn Gln Arg Met Asp Ser Tyr 
145                 150                 155                 160 


Ala His Met Asn Gly Trp Ser Asn Gly Ser Tyr Ser Met Met Gln Asp 
                165                 170                 175     


Gln Leu Gly Tyr Pro Gln His Pro Gly Leu Asn Ala His Gly Ala Ala 
            180                 185                 190         


Gln Met Gln Pro Met His Arg Tyr Asp Val Ser Ala Leu Gln Tyr Asn 
        195                 200                 205             


Ser Met Thr Ser Ser Gln Thr Tyr Met Asn Gly Ser Pro Thr Tyr Ser 
    210                 215                 220                 


Met Ser Tyr Ser Gln Gln Gly Thr Pro Gly Met Ala Leu Gly Ser Met 
225                 230                 235                 240 


Gly Ser Val Val Lys Ser Glu Ala Ser Ser Ser Pro Pro Val Val Thr 
                245                 250                 255     


Ser Ser Ser His Ser Arg Ala Pro Cys Gln Ala Gly Asp Leu Arg Asp 
            260                 265                 270         


Met Ile Ser Met Tyr Leu Pro Gly Ala Glu Val Pro Glu Pro Ala Ala 
        275                 280                 285             


Pro Ser Arg Leu His Met Ser Gln His Tyr Gln Ser Gly Pro Val Pro 
    290                 295                 300                 


Gly Thr Ala Ile Asn Gly Thr Leu Pro Leu Ser His Met 
305                 310                 315         


<210>  20
<211>  1083
<212>  DNA
<213>  Homo sapiens

<400>  20
atggcgggac acctggcttc agattttgcc ttctcgcccc ctccaggtgg tggaggtgat       60

gggccagggg ggccggagcc gggctgggtt gatcctcgga cctggctaag cttccaaggc      120

cctcctggag ggccaggaat cgggccgggg gttgggccag gctctgaggt gtgggggatt      180

cccccatgcc ccccgccgta tgagttctgt ggggggatgg cgtactgtgg gccccaggtt      240

ggagtggggc tagtgcccca aggcggcttg gagacctctc agcctgaggg cgaagcagga      300

gtcggggtgg agagcaactc cgatggggcc tccccggagc cctgcaccgt cacccctggt      360

gccgtgaagc tggagaagga gaagctggag caaaacccgg aggagtccca ggacatcaaa      420

gctctgcaga aagaactcga gcaatttgcc aagctcctga agcagaagag gatcaccctg      480

ggatatacac aggccgatgt ggggctcacc ctgggggttc tatttgggaa ggtattcagc      540

caaacgacca tctgccgctt tgaggctctg cagcttagct tcaagaacat gtgtaagctg      600

cggcccttgc tgcagaagtg ggtggaggaa gctgacaaca atgaaaatct tcaggagata      660

tgcaaagcag aaaccctcgt gcaggcccga aagagaaagc gaaccagtat cgagaaccga      720

gtgagaggca acctggagaa tttgttcctg cagtgcccga aacccacact gcagcagatc      780

agccacatcg cccagcagct tgggctcgag aaggatgtgg tccgagtgtg gttctgtaac      840

cggcgccaga agggcaagcg atcaagcagc gactatgcac aacgagagga ttttgaggct      900

gctgggtctc ctttctcagg gggaccagtg tcctttcctc tggccccagg gccccatttt      960

ggtaccccag gctatgggag ccctcacttc actgcactgt actcctcggt ccctttccct     1020

gagggggaag cctttccccc tgtctctgtc accactctgg gctctcccat gcattcaaac     1080

tga                                                                   1083


<210>  21
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Gly His Leu Ala Ser Asp Phe Ala Phe Ser Pro Pro Pro Gly 
1               5                   10                  15      


Gly Gly Gly Asp Gly Pro Gly Gly Pro Glu Pro Gly Trp Val Asp Pro 
            20                  25                  30          


Arg Thr Trp Leu Ser Phe Gln Gly Pro Pro Gly Gly Pro Gly Ile Gly 
        35                  40                  45              


Pro Gly Val Gly Pro Gly Ser Glu Val Trp Gly Ile Pro Pro Cys Pro 
    50                  55                  60                  


Pro Pro Tyr Glu Phe Cys Gly Gly Met Ala Tyr Cys Gly Pro Gln Val 
65                  70                  75                  80  


Gly Val Gly Leu Val Pro Gln Gly Gly Leu Glu Thr Ser Gln Pro Glu 
                85                  90                  95      


Gly Glu Ala Gly Val Gly Val Glu Ser Asn Ser Asp Gly Ala Ser Pro 
            100                 105                 110         


Glu Pro Cys Thr Val Thr Pro Gly Ala Val Lys Leu Glu Lys Glu Lys 
        115                 120                 125             


Leu Glu Gln Asn Pro Glu Glu Ser Gln Asp Ile Lys Ala Leu Gln Lys 
    130                 135                 140                 


Glu Leu Glu Gln Phe Ala Lys Leu Leu Lys Gln Lys Arg Ile Thr Leu 
145                 150                 155                 160 


Gly Tyr Thr Gln Ala Asp Val Gly Leu Thr Leu Gly Val Leu Phe Gly 
                165                 170                 175     


Lys Val Phe Ser Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu 
            180                 185                 190         


Ser Phe Lys Asn Met Cys Lys Leu Arg Pro Leu Leu Gln Lys Trp Val 
        195                 200                 205             


Glu Glu Ala Asp Asn Asn Glu Asn Leu Gln Glu Ile Cys Lys Ala Glu 
    210                 215                 220                 


Thr Leu Val Gln Ala Arg Lys Arg Lys Arg Thr Ser Ile Glu Asn Arg 
225                 230                 235                 240 


Val Arg Gly Asn Leu Glu Asn Leu Phe Leu Gln Cys Pro Lys Pro Thr 
                245                 250                 255     


Leu Gln Gln Ile Ser His Ile Ala Gln Gln Leu Gly Leu Glu Lys Asp 
            260                 265                 270         


Val Val Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Gly Lys Arg Ser 
        275                 280                 285             


Ser Ser Asp Tyr Ala Gln Arg Glu Asp Phe Glu Ala Ala Gly Ser Pro 
    290                 295                 300                 


Phe Ser Gly Gly Pro Val Ser Phe Pro Leu Ala Pro Gly Pro His Phe 
305                 310                 315                 320 


Gly Thr Pro Gly Tyr Gly Ser Pro His Phe Thr Ala Leu Tyr Ser Ser 
                325                 330                 335     


Val Pro Phe Pro Glu Gly Glu Ala Phe Pro Pro Val Ser Val Thr Thr 
            340                 345                 350         


Leu Gly Ser Pro Met His Ser Asn 
        355                 360 


<210>  22
<211>  459
<212>  DNA
<213>  Homo sapiens

<400>  22
atggccaacc tggagcgcac cttcatcgcc atcaagccgg acggcgtgca gcgcggcctg       60

gtgggcgaga tcatcaagcg cttcgagcag aagggattcc gcctcgtggc catgaagttc      120

ctccgggcct ctgaagaaca cctgaagcag cactacattg acctgaaaga ccgaccattc      180

ttccctgggc tggtgaagta catgaactca gggccggttg tggccatggt ctgggagggg      240

ctgaacgtgg tgaagacagg ccgagtgatg cttggggaga ccaatccagc agattcaaag      300

ccaggcacca ttcgtgggga cttctgcatt caggttggca ggaacatcat tcatggcagt      360

gattcagtaa aaagtgctga aaaagaaatc agcctatggt ttaagcctga agaactggtt      420

gactacaagt cttgtgctca tgactgggtc tatgaataa                             459


<210>  23
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ala Asn Leu Glu Arg Thr Phe Ile Ala Ile Lys Pro Asp Gly Val 
1               5                   10                  15      


Gln Arg Gly Leu Val Gly Glu Ile Ile Lys Arg Phe Glu Gln Lys Gly 
            20                  25                  30          


Phe Arg Leu Val Ala Met Lys Phe Leu Arg Ala Ser Glu Glu His Leu 
        35                  40                  45              


Lys Gln His Tyr Ile Asp Leu Lys Asp Arg Pro Phe Phe Pro Gly Leu 
    50                  55                  60                  


Val Lys Tyr Met Asn Ser Gly Pro Val Val Ala Met Val Trp Glu Gly 
65                  70                  75                  80  


Leu Asn Val Val Lys Thr Gly Arg Val Met Leu Gly Glu Thr Asn Pro 
                85                  90                  95      


Ala Asp Ser Lys Pro Gly Thr Ile Arg Gly Asp Phe Cys Ile Gln Val 
            100                 105                 110         


Gly Arg Asn Ile Ile His Gly Ser Asp Ser Val Lys Ser Ala Glu Lys 
        115                 120                 125             


Glu Ile Ser Leu Trp Phe Lys Pro Glu Glu Leu Val Asp Tyr Lys Ser 
    130                 135                 140                 


Cys Ala His Asp Trp Val Tyr Glu 
145                 150         


<210>  24
<211>  1410
<212>  DNA
<213>  Homo sapiens

<400>  24
atggctgtca gcgacgcgct gctcccatct ttctccacgt tcgcgtctgg cccggcggga       60

agggagaaga cactgcgtca agcaggtgcc ccgaataacc gctggcggga ggagctctcc      120

cacatgaagc gacttccccc agtgcttccc gccggcccct atgacctggc ggcggcgacc      180

gtggccacag acctggagag cgccggagcc ggtgcggctt gcggcggtag caacctggcg      240

cccctacctc ggagagagac cgaggagttc aacgatctcc tggacctgga ctttattctc      300

tccaattcgc tgacccatcc tccggagtca gtggccgcca ccgtgtcctc gtcagcgtca      360

gcctcctctt cgtcgtcgcc gtcgagcagc ggccctgcca gcgcgccctc cacctgcagc      420

ttcacctatc cgatccgggc cgggaacgac ccgggcgtgg cgccgggcgg cacgggcgga      480

ggcctcctct atggcaggga gtccgctccc cctccgacgg ctcccttcaa cctggcggac      540

atcaacgacg tgagcccctc gggcggcttc gtggccgagc tcctgcggcc agaattggac      600

ccggtgtaca ttccgccgca gcagccgcag ccgccaggtg gcgggctgat gggcaagttc      660

gtgctgaagg cgtcgctgag cgcccctggc agcgagtacg gcagcccgtc ggtcatcagc      720

gtcacgaaag gcagccctga cggcagccac ccggtggtgg tggcgcccta caacggcggg      780

ccgccgcgca cgtgccccaa gatcaagcag gaggcggtct cttcgtgcac ccacttgggc      840

gctggacccc ctctcagcaa tggccaccgg ccggctgcac acgacttccc cctggggcgg      900

cagctcccca gcaggactac cccgaccctg ggtcttgagg aagtgctgag cagcagggac      960

tgtcaccctg ccctgccgct tcctcccggc ttccatcccc acccggggcc caattaccca     1020

tccttcctgc ccgatcagat gcagccgcaa gtcccgccgc tccattacca agagctcatg     1080

ccacccggtt cctgcatgcc agaggagccc aagccaaaga ggggaagacg atcgtggccc     1140

cggaaaagga ccgccaccca cacttgtgat tacgcgggct gcggcaaaac ctacacaaag     1200

agttcccatc tcaaggcaca cctgcgaacc cacacaggtg agaaacctta ccactgtgac     1260

tgggacggct gtggatggaa attcgcccgc tcagatgaac tgaccaggca ctaccgtaaa     1320

cacacggggc accgcccgtt ccagtgccaa aaatgcgacc gagcattttc caggtcggac     1380

cacctcgcct tacacatgaa gaggcatttt                                      1410


<210>  25
<211>  470
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ala Val Ser Asp Ala Leu Leu Pro Ser Phe Ser Thr Phe Ala Ser 
1               5                   10                  15      


Gly Pro Ala Gly Arg Glu Lys Thr Leu Arg Gln Ala Gly Ala Pro Asn 
            20                  25                  30          


Asn Arg Trp Arg Glu Glu Leu Ser His Met Lys Arg Leu Pro Pro Val 
        35                  40                  45              


Leu Pro Ala Gly Pro Tyr Asp Leu Ala Ala Ala Thr Val Ala Thr Asp 
    50                  55                  60                  


Leu Glu Ser Ala Gly Ala Gly Ala Ala Cys Gly Gly Ser Asn Leu Ala 
65                  70                  75                  80  


Pro Leu Pro Arg Arg Glu Thr Glu Glu Phe Asn Asp Leu Leu Asp Leu 
                85                  90                  95      


Asp Phe Ile Leu Ser Asn Ser Leu Thr His Pro Pro Glu Ser Val Ala 
            100                 105                 110         


Ala Thr Val Ser Ser Ser Ala Ser Ala Ser Ser Ser Ser Ser Pro Ser 
        115                 120                 125             


Ser Ser Gly Pro Ala Ser Ala Pro Ser Thr Cys Ser Phe Thr Tyr Pro 
    130                 135                 140                 


Ile Arg Ala Gly Asn Asp Pro Gly Val Ala Pro Gly Gly Thr Gly Gly 
145                 150                 155                 160 


Gly Leu Leu Tyr Gly Arg Glu Ser Ala Pro Pro Pro Thr Ala Pro Phe 
                165                 170                 175     


Asn Leu Ala Asp Ile Asn Asp Val Ser Pro Ser Gly Gly Phe Val Ala 
            180                 185                 190         


Glu Leu Leu Arg Pro Glu Leu Asp Pro Val Tyr Ile Pro Pro Gln Gln 
        195                 200                 205             


Pro Gln Pro Pro Gly Gly Gly Leu Met Gly Lys Phe Val Leu Lys Ala 
    210                 215                 220                 


Ser Leu Ser Ala Pro Gly Ser Glu Tyr Gly Ser Pro Ser Val Ile Ser 
225                 230                 235                 240 


Val Thr Lys Gly Ser Pro Asp Gly Ser His Pro Val Val Val Ala Pro 
                245                 250                 255     


Tyr Asn Gly Gly Pro Pro Arg Thr Cys Pro Lys Ile Lys Gln Glu Ala 
            260                 265                 270         


Val Ser Ser Cys Thr His Leu Gly Ala Gly Pro Pro Leu Ser Asn Gly 
        275                 280                 285             


His Arg Pro Ala Ala His Asp Phe Pro Leu Gly Arg Gln Leu Pro Ser 
    290                 295                 300                 


Arg Thr Thr Pro Thr Leu Gly Leu Glu Glu Val Leu Ser Ser Arg Asp 
305                 310                 315                 320 


Cys His Pro Ala Leu Pro Leu Pro Pro Gly Phe His Pro His Pro Gly 
                325                 330                 335     


Pro Asn Tyr Pro Ser Phe Leu Pro Asp Gln Met Gln Pro Gln Val Pro 
            340                 345                 350         


Pro Leu His Tyr Gln Glu Leu Met Pro Pro Gly Ser Cys Met Pro Glu 
        355                 360                 365             


Glu Pro Lys Pro Lys Arg Gly Arg Arg Ser Trp Pro Arg Lys Arg Thr 
    370                 375                 380                 


Ala Thr His Thr Cys Asp Tyr Ala Gly Cys Gly Lys Thr Tyr Thr Lys 
385                 390                 395                 400 


Ser Ser His Leu Lys Ala His Leu Arg Thr His Thr Gly Glu Lys Pro 
                405                 410                 415     


Tyr His Cys Asp Trp Asp Gly Cys Gly Trp Lys Phe Ala Arg Ser Asp 
            420                 425                 430         


Glu Leu Thr Arg His Tyr Arg Lys His Thr Gly His Arg Pro Phe Gln 
        435                 440                 445             


Cys Gln Lys Cys Asp Arg Ala Phe Ser Arg Ser Asp His Leu Ala Leu 
    450                 455                 460                 


His Met Lys Arg His Phe 
465                 470 


<210>  26
<211>  1362
<212>  DNA
<213>  Homo sapiens

<400>  26
atggattttt ttcgggtagt ggaaaaccag cagcctcccg cgacgatgcc cctcaacgtt       60

agcttcacca acaggaacta tgacctcgac tacgactcgg tgcagccgta tttctactgc      120

gacgaggagg agaacttcta ccagcagcag cagcagagcg agctgcagcc cccggcgccc      180

agcgaggata tctggaagaa attcgagctg ctgcccaccc cgcccctgtc ccctagccgc      240

cgctccgggc tctgctcgcc ctcctacgtt gcggtcacac ccttctccct tcggggagac      300

aacgacggcg gtggcgggag cttctccacg gccgaccagc tggagatggt gaccgagctg      360

ctgggaggag acatggtgaa ccagagtttc atctgcgacc cggacgacga gaccttcatc      420

aaaaacatca tcatccagga ctgtatgtgg agcggcttct cggccgccgc caagctcgtc      480

tcagagaagc tggcctccta ccaggctgcg cgcaaagaca gcggcagccc gaaccccgcc      540

cgcggccaca gcgtctgctc cacctccagc ttgtacctgc aggatctgag cgccgccgcc      600

tcagagtgca tcgacccctc ggtggtcttc ccctaccctc tcaacgacag cagctcgccc      660

aagtcctgcg cctcgcaaga ctccagcgcc ttctctccgt cctcggattc tctgctctcc      720

tcgacggagt cctccccgca gggcagcccc gagcccctgg tgctccatga ggagacaccg      780

cccaccacca gcagcgactc tgaggaggaa caagaagatg aggaagaaat cgatgttgtt      840

tctgtggaaa agaggcaggc tcctggcaaa aggtcagagt ctggatcacc ttctgctgga      900

ggccacagca aacctcctca cagcccactg gtcctcaaga ggtgccacgt ctccacacat      960

cagcacaact acgcagcgcc tccctccact cggaaggact atcctgctgc caagagggtc     1020

aagttggaca gtgtcagagt cctgagacag atcagcaaca accgaaaatg caccagcccc     1080

aggtcctcgg acaccgagga gaatgtcaag aggcgaacac acaacgtctt ggagcgccag     1140

aggaggaacg agctaaaacg gagctttttt gccctgcgtg accagatccc ggagttggaa     1200

aacaatgaaa aggcccccaa ggtagttatc cttaaaaaag ccacagcata catcctgtcc     1260

gtccaagcag aggagcaaaa gctcatttct gaagaggact tgttgcggaa acgacgagaa     1320

cagttgaaac acaaacttga acagctacgg aactcttgtg cg                        1362


<210>  27
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Asp Phe Phe Arg Val Val Glu Asn Gln Gln Pro Pro Ala Thr Met 
1               5                   10                  15      


Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr Asp 
            20                  25                  30          


Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr Gln 
        35                  40                  45              


Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp Ile 
    50                  55                  60                  


Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg 
65                  70                  75                  80  


Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe Ser 
                85                  90                  95      


Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala Asp 
            100                 105                 110         


Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn Gln 
        115                 120                 125             


Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile Ile 
    130                 135                 140                 


Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu Val 
145                 150                 155                 160 


Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly Ser 
                165                 170                 175     


Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu Tyr 
            180                 185                 190         


Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser Val 
        195                 200                 205             


Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys Ala 
    210                 215                 220                 


Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu Ser 
225                 230                 235                 240 


Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu His 
                245                 250                 255     


Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln Glu 
            260                 265                 270         


Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser Lys 
    290                 295                 300                 


Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr His 
305                 310                 315                 320 


Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro Ala 
                325                 330                 335     


Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile Ser 
            340                 345                 350         


Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu Asn 
        355                 360                 365             


Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn Glu 
    370                 375                 380                 


Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu Glu 
385                 390                 395                 400 


Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr Ala 
                405                 410                 415     


Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu Glu 
            420                 425                 430         


Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu Gln 
        435                 440                 445             


Leu Arg Asn Ser Cys Ala 
    450                 


<210>  28
<211>  627
<212>  DNA
<213>  Homo sapiens

<400>  28
atgggctccg tgtccaacca gcagtttgca ggtggctgcg ccaaggcggc agaagaggcg       60

cccgaggagg cgccggagga cgcggcccgg gcggcggacg agcctcagct gctgcacggt      120

gcgggcatct gtaagtggtt caacgtgcgc atggggttcg gcttcctgtc catgaccgcc      180

cgcgccgggg tcgcgctcga ccccccagtg gatgtctttg tgcaccagag taagctgcac      240

atggaagggt tccggagctt gaaggagggt gaggcagtgg agttcacctt taagaagtca      300

gccaagggtc tggaatccat ccgtgtcacc ggacctggtg gagtattctg tattgggagt      360

gagaggcggc caaaaggaaa gagcatgcag aagcgcagat caaaaggaga caggtgctac      420

aactgtggag gtctagatca tcatgccaag gaatgcaagc tgccacccca gcccaagaag      480

tgccacttct gccagagcat cagccatatg gtagcctcat gtccgctgaa ggcccagcag      540

ggccctagtg cacagggaaa gccaacctac tttcgagagg aagaagaaga aatccacagc      600

cctaccctgc tcccggaggc acagaat                                          627


<210>  29
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Gly Ser Val Ser Asn Gln Gln Phe Ala Gly Gly Cys Ala Lys Ala 
1               5                   10                  15      


Ala Glu Glu Ala Pro Glu Glu Ala Pro Glu Asp Ala Ala Arg Ala Ala 
            20                  25                  30          


Asp Glu Pro Gln Leu Leu His Gly Ala Gly Ile Cys Lys Trp Phe Asn 
        35                  40                  45              


Val Arg Met Gly Phe Gly Phe Leu Ser Met Thr Ala Arg Ala Gly Val 
    50                  55                  60                  


Ala Leu Asp Pro Pro Val Asp Val Phe Val His Gln Ser Lys Leu His 
65                  70                  75                  80  


Met Glu Gly Phe Arg Ser Leu Lys Glu Gly Glu Ala Val Glu Phe Thr 
                85                  90                  95      


Phe Lys Lys Ser Ala Lys Gly Leu Glu Ser Ile Arg Val Thr Gly Pro 
            100                 105                 110         


Gly Gly Val Phe Cys Ile Gly Ser Glu Arg Arg Pro Lys Gly Lys Ser 
        115                 120                 125             


Met Gln Lys Arg Arg Ser Lys Gly Asp Arg Cys Tyr Asn Cys Gly Gly 
    130                 135                 140                 


Leu Asp His His Ala Lys Glu Cys Lys Leu Pro Pro Gln Pro Lys Lys 
145                 150                 155                 160 


Cys His Phe Cys Gln Ser Ile Ser His Met Val Ala Ser Cys Pro Leu 
                165                 170                 175     


Lys Ala Gln Gln Gly Pro Ser Ala Gln Gly Lys Pro Thr Tyr Phe Arg 
            180                 185                 190         


Glu Glu Glu Glu Glu Ile His Ser Pro Thr Leu Leu Pro Glu Ala Gln 
        195                 200                 205             


Asn 
    


<210>  30
<211>  1746
<212>  DNA
<213>  Homo sapiens

<400>  30
atgtctcccg ccccaagacc ctcccgttgt ctcctgctcc ccctgctcac gctcggcacc       60

gcgctcgcct ccctcggctc ggcccaaagc agcagcttca gccccgaagc ctggctacag      120

caatatggct acctgcctcc cggggaccta cgtacccaca cacagcgctc accccagtca      180

ctctcagcgg ccatcgctgc catgcagaag ttttacggct tgcaagtaac aggcaaagct      240

gatgcagaca ccatgaaggc catgaggcgc ccccgatgtg gtgttccaga caagtttggg      300

gctgagatca aggccaatgt tcgaaggaag cgctacgcca tccagggtct caaatggcaa      360

cataatgaaa tcactttctg catccagaat tacaccccca aggtgggcga gtatgccaca      420

tacgaggcca ttcgcaaggc gttccgcgtg tgggagagtg ccacaccact gcgcttccgc      480

gaggtgccct atgcctacat ccgtgagggc catgagaagc aggccgacat catgatcttc      540

tttgccgagg gcttccatgg cgacagcacg cccttcgatg gtgagggcgg cttcctggcc      600

catgcctact tcccaggccc caacattgga ggagacaccc actttgactc tgccgagcct      660

tggactgtca ggaatgagga tctgaatgga aatgacatct tcctggtggc tgtgcacgag      720

ctgggccatg ccctggggct cgagcattcc agtgacccct cggccatcat ggcacccttt      780

taccagtgga tggacacgga gaattttgtg ctgcccgatg atgaccgccg gggcatccag      840

caactttatg ggggtgagtc agggttcccc accaagatgc cccctcaacc caggactacc      900

tcccggcctt ctgttcctga taaacccaaa aaccccacct atgggcccaa catctgtgac      960

gggaactttg acaccgtggc catgctccga ggggagatgt ttgtcttcaa ggagcgctgg     1020

ttctggcggg tgaggaataa ccaagtgatg gatggatacc caatgcccat tggccagttc     1080

tggcggggcc tgcctgcgtc catcaacact gcctacgaga ggaaggatgg caaattcgtc     1140

ttcttcaaag gagacaagca ttgggtgttt gatgaggcgt ccctggaacc tggctacccc     1200

aagcacatta aggagctggg ccgagggctg cctaccgaca agattgatgc tgctctcttc     1260

tggatgccca atggaaagac ctacttcttc cgtggaaaca agtactaccg tttcaacgaa     1320

gagctcaggg cagtggatag cgagtacccc aagaacatca aagtctggga agggatccct     1380

gagtctccca gagggtcatt catgggcagc gatgaagtct tcacttactt ctacaagggg     1440

aacaaatact ggaaattcaa caaccagaag ctgaaggtag aaccgggcta ccccaagtca     1500

gccctgaggg actggatggg ctgcccatcg ggaggccggc cggatgaggg gactgaggag     1560

gagacggagg tgatcatcat tgaggtggac gaggagggcg gcggggcggt gagcgcggct     1620

gccgtggtgc tgcccgtgct gctgctgctc ctggtgctgg cggtgggcct tgcagtcttc     1680

ttcttcagac gccatgggac ccccaggcga ctgctctact gccagcgttc cctgctggac     1740

aaggtc                                                                1746


<210>  31
<211>  582
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Ser Pro Ala Pro Arg Pro Ser Arg Cys Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Thr Leu Gly Thr Ala Leu Ala Ser Leu Gly Ser Ala Gln Ser Ser Ser 
            20                  25                  30          


Phe Ser Pro Glu Ala Trp Leu Gln Gln Tyr Gly Tyr Leu Pro Pro Gly 
        35                  40                  45              


Asp Leu Arg Thr His Thr Gln Arg Ser Pro Gln Ser Leu Ser Ala Ala 
    50                  55                  60                  


Ile Ala Ala Met Gln Lys Phe Tyr Gly Leu Gln Val Thr Gly Lys Ala 
65                  70                  75                  80  


Asp Ala Asp Thr Met Lys Ala Met Arg Arg Pro Arg Cys Gly Val Pro 
                85                  90                  95      


Asp Lys Phe Gly Ala Glu Ile Lys Ala Asn Val Arg Arg Lys Arg Tyr 
            100                 105                 110         


Ala Ile Gln Gly Leu Lys Trp Gln His Asn Glu Ile Thr Phe Cys Ile 
        115                 120                 125             


Gln Asn Tyr Thr Pro Lys Val Gly Glu Tyr Ala Thr Tyr Glu Ala Ile 
    130                 135                 140                 


Arg Lys Ala Phe Arg Val Trp Glu Ser Ala Thr Pro Leu Arg Phe Arg 
145                 150                 155                 160 


Glu Val Pro Tyr Ala Tyr Ile Arg Glu Gly His Glu Lys Gln Ala Asp 
                165                 170                 175     


Ile Met Ile Phe Phe Ala Glu Gly Phe His Gly Asp Ser Thr Pro Phe 
            180                 185                 190         


Asp Gly Glu Gly Gly Phe Leu Ala His Ala Tyr Phe Pro Gly Pro Asn 
        195                 200                 205             


Ile Gly Gly Asp Thr His Phe Asp Ser Ala Glu Pro Trp Thr Val Arg 
    210                 215                 220                 


Asn Glu Asp Leu Asn Gly Asn Asp Ile Phe Leu Val Ala Val His Glu 
225                 230                 235                 240 


Leu Gly His Ala Leu Gly Leu Glu His Ser Ser Asp Pro Ser Ala Ile 
                245                 250                 255     


Met Ala Pro Phe Tyr Gln Trp Met Asp Thr Glu Asn Phe Val Leu Pro 
            260                 265                 270         


Asp Asp Asp Arg Arg Gly Ile Gln Gln Leu Tyr Gly Gly Glu Ser Gly 
        275                 280                 285             


Phe Pro Thr Lys Met Pro Pro Gln Pro Arg Thr Thr Ser Arg Pro Ser 
    290                 295                 300                 


Val Pro Asp Lys Pro Lys Asn Pro Thr Tyr Gly Pro Asn Ile Cys Asp 
305                 310                 315                 320 


Gly Asn Phe Asp Thr Val Ala Met Leu Arg Gly Glu Met Phe Val Phe 
                325                 330                 335     


Lys Glu Arg Trp Phe Trp Arg Val Arg Asn Asn Gln Val Met Asp Gly 
            340                 345                 350         


Tyr Pro Met Pro Ile Gly Gln Phe Trp Arg Gly Leu Pro Ala Ser Ile 
        355                 360                 365             


Asn Thr Ala Tyr Glu Arg Lys Asp Gly Lys Phe Val Phe Phe Lys Gly 
    370                 375                 380                 


Asp Lys His Trp Val Phe Asp Glu Ala Ser Leu Glu Pro Gly Tyr Pro 
385                 390                 395                 400 


Lys His Ile Lys Glu Leu Gly Arg Gly Leu Pro Thr Asp Lys Ile Asp 
                405                 410                 415     


Ala Ala Leu Phe Trp Met Pro Asn Gly Lys Thr Tyr Phe Phe Arg Gly 
            420                 425                 430         


Asn Lys Tyr Tyr Arg Phe Asn Glu Glu Leu Arg Ala Val Asp Ser Glu 
        435                 440                 445             


Tyr Pro Lys Asn Ile Lys Val Trp Glu Gly Ile Pro Glu Ser Pro Arg 
    450                 455                 460                 


Gly Ser Phe Met Gly Ser Asp Glu Val Phe Thr Tyr Phe Tyr Lys Gly 
465                 470                 475                 480 


Asn Lys Tyr Trp Lys Phe Asn Asn Gln Lys Leu Lys Val Glu Pro Gly 
                485                 490                 495     


Tyr Pro Lys Ser Ala Leu Arg Asp Trp Met Gly Cys Pro Ser Gly Gly 
            500                 505                 510         


Arg Pro Asp Glu Gly Thr Glu Glu Glu Thr Glu Val Ile Ile Ile Glu 
        515                 520                 525             


Val Asp Glu Glu Gly Gly Gly Ala Val Ser Ala Ala Ala Val Val Leu 
    530                 535                 540                 


Pro Val Leu Leu Leu Leu Leu Val Leu Ala Val Gly Leu Ala Val Phe 
545                 550                 555                 560 


Phe Phe Arg Arg His Gly Thr Pro Arg Arg Leu Leu Tyr Cys Gln Arg 
                565                 570                 575     


Ser Leu Leu Asp Lys Val 
            580         


<210>  32
<211>  1821
<212>  DNA
<213>  Homo sapiens

<400>  32
atgatcttac tcacattcag cactggaaga cggttggatt tcgtgcatca ttcgggggtg       60

tttttcttgc aaaccttgct ttggatttta tgtgctacag tctgcggaac ggagcagtat      120

ttcaatgtgg aggtttggtt acaaaagtac ggctaccttc caccgactga ccccagaatg      180

tcagtgctgc gctctgcaga gaccatgcag tctgccctag ctgccatgca gcagttctat      240

ggcattaaca tgacaggaaa agtggacaga aacacaattg actggatgaa gaagccccga      300

tgcggtgtac ctgaccagac aagaggtagc tccaaatttc atattcgtcg aaagcgatat      360

gcattgacag gacagaaatg gcagcacaag cacatcactt acagtataaa gaacgtaact      420

ccaaaagtag gagaccctga gactcgtaaa gctattcgcc gtgcctttga tgtgtggcag      480

aatgtaactc ctctgacatt tgaagaagtt ccctacagtg aattagaaaa tggcaaacgt      540

gatgtggata taaccattat ttttgcatct ggtttccatg gggacagctc tccctttgat      600

ggagagggag gatttttggc acatgcctac ttccctggac caggaattgg aggagatacc      660

cattttgact cagatgagcc atggacacta ggaaatccta atcatgatgg aaatgactta      720

tttcttgtag cagtccatga actgggacat gctctgggat tggagcattc caatgacccc      780

actgccatca tggctccatt ttaccagtac atggaaacag acaacttcaa actacctaat      840

gatgatttac agggcatcca gaaaatatat ggtccacctg acaagattcc tccacctaca      900

agacctctac cgacagtgcc cccacaccgc tctattcctc cggctgaccc aaggaaaaat      960

gacaggccaa aacctcctcg gcctccaacc ggcagaccct cctatcccgg agccaaaccc     1020

aacatctgtg atgggaactt taacactcta gctattcttc gtcgtgagat gtttgttttc     1080

aaggaccagt ggttttggcg agtgagaaac aacagggtga tggatggata cccaatgcaa     1140

attacttact tctggcgggg cttgcctcct agtatcgatg cagtttatga aaatagcgac     1200

gggaattttg tgttctttaa aggtaacaaa tattgggtgt tcaaggatac aactcttcaa     1260

cctggttacc ctcatgactt gataaccctt ggaagtggaa ttccccctca tggtattgat     1320

tcagccattt ggtgggagga cgtcgggaaa acctatttct tcaagggaga cagatattgg     1380

agatatagtg aagaaatgaa aacaatggac cctggctatc ccaagccaat cacagtctgg     1440

aaagggatcc ctgaatctcc tcagggagca tttgtacaca aagaaaatgg ctttacgtat     1500

ttctacaaag gaaaggagta ttggaaattc aacaaccaga tactcaaggt agaacctgga     1560

catccaagat ccatcctcaa ggattttatg ggctgtgatg gaccaacaga cagagttaaa     1620

gaaggacaca gcccaccaga tgatgtagac attgtcatca aactggacaa cacagccagc     1680

actgtgaaag ccatagctat tgtcattccc tgcatcttgg ccttatgcct ccttgtattg     1740

gtttacactg tgttccagtt caagaggaaa ggaacacccc gccacatact gtactgtaaa     1800

cgctctatgc aagagtgggt g                                               1821


<210>  33
<211>  607
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ile Leu Leu Thr Phe Ser Thr Gly Arg Arg Leu Asp Phe Val His 
1               5                   10                  15      


His Ser Gly Val Phe Phe Leu Gln Thr Leu Leu Trp Ile Leu Cys Ala 
            20                  25                  30          


Thr Val Cys Gly Thr Glu Gln Tyr Phe Asn Val Glu Val Trp Leu Gln 
        35                  40                  45              


Lys Tyr Gly Tyr Leu Pro Pro Thr Asp Pro Arg Met Ser Val Leu Arg 
    50                  55                  60                  


Ser Ala Glu Thr Met Gln Ser Ala Leu Ala Ala Met Gln Gln Phe Tyr 
65                  70                  75                  80  


Gly Ile Asn Met Thr Gly Lys Val Asp Arg Asn Thr Ile Asp Trp Met 
                85                  90                  95      


Lys Lys Pro Arg Cys Gly Val Pro Asp Gln Thr Arg Gly Ser Ser Lys 
            100                 105                 110         


Phe His Ile Arg Arg Lys Arg Tyr Ala Leu Thr Gly Gln Lys Trp Gln 
        115                 120                 125             


His Lys His Ile Thr Tyr Ser Ile Lys Asn Val Thr Pro Lys Val Gly 
    130                 135                 140                 


Asp Pro Glu Thr Arg Lys Ala Ile Arg Arg Ala Phe Asp Val Trp Gln 
145                 150                 155                 160 


Asn Val Thr Pro Leu Thr Phe Glu Glu Val Pro Tyr Ser Glu Leu Glu 
                165                 170                 175     


Asn Gly Lys Arg Asp Val Asp Ile Thr Ile Ile Phe Ala Ser Gly Phe 
            180                 185                 190         


His Gly Asp Ser Ser Pro Phe Asp Gly Glu Gly Gly Phe Leu Ala His 
        195                 200                 205             


Ala Tyr Phe Pro Gly Pro Gly Ile Gly Gly Asp Thr His Phe Asp Ser 
    210                 215                 220                 


Asp Glu Pro Trp Thr Leu Gly Asn Pro Asn His Asp Gly Asn Asp Leu 
225                 230                 235                 240 


Phe Leu Val Ala Val His Glu Leu Gly His Ala Leu Gly Leu Glu His 
                245                 250                 255     


Ser Asn Asp Pro Thr Ala Ile Met Ala Pro Phe Tyr Gln Tyr Met Glu 
            260                 265                 270         


Thr Asp Asn Phe Lys Leu Pro Asn Asp Asp Leu Gln Gly Ile Gln Lys 
        275                 280                 285             


Ile Tyr Gly Pro Pro Asp Lys Ile Pro Pro Pro Thr Arg Pro Leu Pro 
    290                 295                 300                 


Thr Val Pro Pro His Arg Ser Ile Pro Pro Ala Asp Pro Arg Lys Asn 
305                 310                 315                 320 


Asp Arg Pro Lys Pro Pro Arg Pro Pro Thr Gly Arg Pro Ser Tyr Pro 
                325                 330                 335     


Gly Ala Lys Pro Asn Ile Cys Asp Gly Asn Phe Asn Thr Leu Ala Ile 
            340                 345                 350         


Leu Arg Arg Glu Met Phe Val Phe Lys Asp Gln Trp Phe Trp Arg Val 
        355                 360                 365             


Arg Asn Asn Arg Val Met Asp Gly Tyr Pro Met Gln Ile Thr Tyr Phe 
    370                 375                 380                 


Trp Arg Gly Leu Pro Pro Ser Ile Asp Ala Val Tyr Glu Asn Ser Asp 
385                 390                 395                 400 


Gly Asn Phe Val Phe Phe Lys Gly Asn Lys Tyr Trp Val Phe Lys Asp 
                405                 410                 415     


Thr Thr Leu Gln Pro Gly Tyr Pro His Asp Leu Ile Thr Leu Gly Ser 
            420                 425                 430         


Gly Ile Pro Pro His Gly Ile Asp Ser Ala Ile Trp Trp Glu Asp Val 
        435                 440                 445             


Gly Lys Thr Tyr Phe Phe Lys Gly Asp Arg Tyr Trp Arg Tyr Ser Glu 
    450                 455                 460                 


Glu Met Lys Thr Met Asp Pro Gly Tyr Pro Lys Pro Ile Thr Val Trp 
465                 470                 475                 480 


Lys Gly Ile Pro Glu Ser Pro Gln Gly Ala Phe Val His Lys Glu Asn 
                485                 490                 495     


Gly Phe Thr Tyr Phe Tyr Lys Gly Lys Glu Tyr Trp Lys Phe Asn Asn 
            500                 505                 510         


Gln Ile Leu Lys Val Glu Pro Gly His Pro Arg Ser Ile Leu Lys Asp 
        515                 520                 525             


Phe Met Gly Cys Asp Gly Pro Thr Asp Arg Val Lys Glu Gly His Ser 
    530                 535                 540                 


Pro Pro Asp Asp Val Asp Ile Val Ile Lys Leu Asp Asn Thr Ala Ser 
545                 550                 555                 560 


Thr Val Lys Ala Ile Ala Ile Val Ile Pro Cys Ile Leu Ala Leu Cys 
                565                 570                 575     


Leu Leu Val Leu Val Tyr Thr Val Phe Gln Phe Lys Arg Lys Gly Thr 
            580                 585                 590         


Pro Arg His Ile Leu Tyr Cys Lys Arg Ser Met Gln Glu Trp Val 
        595                 600                 605         


<210>  34
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Nonsense polypeptide for control

<400>  34

His His His His His His Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly 
1               5                   10                  15      


Ser Ser Ser Ser Gly Gly Arg Gly Asp Ser Gly Arg Gly Asp Ser 
            20                  25                  30      


