                         SEQUENCE LISTING

<110>  Duke University
       Patz, Edward  F. Jr.
       Gottlin, Elizabeth B.
       Campa, Michael J.
 
<120>  VHH ANTIBODY FRAGMENTS FOR USE IN THE DETECTION AND TREATEMENT OF
        CANCER

<130>  180/268 PCT

<150>  US 61/104,202
<151>  2008-10-09

<160>  53    

<170>  PatentIn version 3.5

<210>  1
<211>  115
<212>  PRT
<213>  Lama glama

<400>  1

Glu Val Lys Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Val Thr Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Phe Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Phe Gly Gly Gly Ile Thr Asn Tyr Gly Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu His Met Asn Gly Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gln Met Gly Ser Lys Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110         


Glu Pro Gln 
        115 


<210>  2
<211>  118
<212>  PRT
<213>  Lama glama

<400>  2

Glu Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Gly Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Ser Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Leu Gly Thr Gly Arg Ala Asn Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser Glu Pro Gln 
        115             


<210>  3
<211>  118
<212>  PRT
<213>  Lama glama

<400>  3

Gln Val Lys Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Gly Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Ser Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Leu Gly Thr Gly Arg Ala Asn Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser Glu Pro Gln 
        115             


<210>  4
<211>  120
<212>  PRT
<213>  Lama glama

<400>  4

Glu Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Asp Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Thr Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Ala Leu Gly Thr Gly Arg Gly Asn Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Glu Pro Gln 
        115                 120 


<210>  5
<211>  120
<212>  PRT
<213>  Lama glama

<400>  5

Glu Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Asp Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Thr Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Ala Leu Gly Thr Gly Arg Gly Asn Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Glu Pro Gln 
        115                 120 


<210>  6
<211>  120
<212>  PRT
<213>  Lama glama

<400>  6

Glu Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Asp Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Thr Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Ala Leu Gly Thr Gly Arg Ala Asn Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Glu Pro Gln 
        115                 120 


<210>  7
<211>  126
<212>  PRT
<213>  Lama glama

<400>  7

Glu Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Lys 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Ala Arg Ala Ala Gly Val Gly 
            20                  25                  30          


Trp Phe Arg Gln Ala Pro Gly Leu Glu Arg Glu Tyr Val Gly Ser Phe 
        35                  40                  45              


Leu Trp Asn Thr Gly Arg Thr His Tyr Pro Glu Ser Leu Lys Asp Arg 
    50                  55                  60                  


Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Ile 
65                  70                  75                  80  


Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala Val 
                85                  90                  95      


Gln Leu Pro Ile Arg Thr Ser Leu Thr Glu Pro Ala Thr Tyr Thr Phe 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ala Ser Glu Pro Gln 
        115                 120                 125     


<210>  8
<211>  118
<212>  PRT
<213>  Lama glama

<400>  8

Glu Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Gly Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Ser Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Leu Gly Thr Gly Arg Ala Asn Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser Glu Pro Gln 
        115             


<210>  9
<211>  120
<212>  PRT
<213>  Lama glama

<400>  9

Glu Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Asp Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Thr Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Ala Leu Gly Thr Gly Arg Gly Asn Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Glu Pro Gln 
        115                 120 


<210>  10
<211>  120
<212>  PRT
<213>  Lama glama

<400>  10

Glu Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Asp Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Thr Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Ala Leu Gly Thr Gly Arg Ala Asn Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Glu Pro Gln 
        115                 120 


<210>  11
<211>  120
<212>  PRT
<213>  Lama glama

<400>  11

Glu Val Lys Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Asp Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Thr Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Ala Leu Gly Thr Gly Arg Ala Asn Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Glu Pro Gln 
        115                 120 


<210>  12
<211>  120
<212>  PRT
<213>  Lama glama

<400>  12

Glu Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Asp Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Thr Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Ala Leu Gly Thr Gly Arg Gly Asn Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Glu Pro Gln 
        115                 120 


<210>  13
<211>  120
<212>  PRT
<213>  Lama glama

<400>  13

Glu Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Asp Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Thr Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Ala Leu Gly Thr Gly Arg Gly Asn Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Glu Pro Gln 
        115                 120 


<210>  14
<211>  118
<212>  PRT
<213>  Lama glama

<400>  14

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Gly Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Ser Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Leu Gly Thr Gly Arg Ala Asn Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser Glu Pro Gln 
        115             


<210>  15
<211>  122
<212>  PRT
<213>  Lama glama

<400>  15

Glu Val Lys Leu Gln Gln Ser Gly Gly Asp Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Pro Tyr Val Met 
            20                  25                  30          


Gly Trp Phe Arg Gln Ala Arg Gly Lys Glu Arg Glu Phe Val Ala Ala 
        35                  40                  45              


Ile Thr Ser Ser Phe Thr Arg Tyr Leu Ala Asp Ser Val Lys Gly Arg 
    50                  55                  60                  


Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Gln Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly 
                85                  90                  95      


Ser Ile Val Arg Pro Ser Thr Asp Ala Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Glu Ala Gln 
        115                 120         


<210>  16
<211>  118
<212>  PRT
<213>  Lama glama

<400>  16

Glu Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Gly Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Ser Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Leu Gly Thr Gly Arg Ala Asn Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser Glu Pro Gln 
        115             


<210>  17
<211>  127
<212>  PRT
<213>  Lama glama

<400>  17

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Leu Val Ser Gly Arg Ser Phe Asn Ser Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Leu Trp Ser Gly Pro Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Leu Gly Val Leu Val Leu Ala Pro Gly Asn Val Tyr Ser 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala His His 
        115                 120                 125         


<210>  18
<211>  120
<212>  PRT
<213>  Lama glama

<400>  18

Glu Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Asp Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Thr Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Ala Leu Gly Thr Gly Arg Gly Asn Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Glu Pro Gln 
        115                 120 


<210>  19
<211>  120
<212>  PRT
<213>  Lama glama

<400>  19

Glu Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Asp Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Thr Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Ala Leu Gly Thr Ala Arg Gly Asn Trp Cys Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Glu Pro Gln 
        115                 120 


<210>  20
<211>  120
<212>  PRT
<213>  Lama glama

<400>  20

Glu Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Asp Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Thr Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Ala Leu Gly Thr Gly Arg Ala Asn Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Glu Pro Gln 
        115                 120 


<210>  21
<211>  120
<212>  PRT
<213>  Lama glama

<400>  21

Gln Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Asp Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Thr Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Ala Leu Gly Thr Gly Arg Gly Asn Trp Gly Gln Gly Thr Arg 
            100                 105                 110         


Val Thr Val Ser Ser Glu Pro Gln 
        115                 120 


<210>  22
<211>  120
<212>  PRT
<213>  Lama glama

<400>  22

Glu Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Asp Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Thr Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Ala Leu Gly Thr Gly Arg Ala Asn Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Glu Pro Gln 
        115                 120 


<210>  23
<211>  120
<212>  PRT
<213>  Lama glama

<400>  23

Glu Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Asp Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Thr Val Ile Ser Ser Val Gly Val Thr Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Ala Leu Gly Thr Gly Arg Ala Asn Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Glu Pro Gln 
        115                 120 


<210>  24
<211>  120
<212>  PRT
<213>  Lama glama

<400>  24

Glu Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Asp Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Thr Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Ala Leu Gly Thr Gly Arg Gly Asn Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Glu Pro Gln 
        115                 120 


<210>  25
<211>  126
<212>  PRT
<213>  Lama glama

<400>  25

Glu Val Lys Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Lys 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Ala Arg Ala Ala Gly Val Gly 
            20                  25                  30          


Trp Phe Arg Gln Ala Pro Gly Leu Glu Arg Glu Tyr Val Gly Ser Phe 
        35                  40                  45              


Leu Trp Asn Thr Gly Arg Thr His Tyr Pro Glu Ser Leu Lys Asp Arg 
    50                  55                  60                  


Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Ile 
65                  70                  75                  80  


Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala Val 
                85                  90                  95      


Gln Leu Pro Ile Arg Thr Ser Leu Thr Glu Pro Ala Thr Tyr Thr Phe 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ala Ser Glu Pro Gln 
        115                 120                 125     


<210>  26
<211>  126
<212>  PRT
<213>  Lama glama

<400>  26

Glu Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Lys 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Ala Arg Ala Ala Gly Val Gly 
            20                  25                  30          


Trp Phe Arg Gln Ala Pro Gly Leu Glu Arg Glu Tyr Val Gly Ser Phe 
        35                  40                  45              


Leu Trp Asn Thr Gly Arg Thr His Tyr Pro Glu Ser Leu Lys Asp Arg 
    50                  55                  60                  


Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Ile 
65                  70                  75                  80  


Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala Val 
                85                  90                  95      


Gln Leu Pro Ile Arg Thr Ser Leu Thr Glu Pro Ala Thr Tyr Thr Phe 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ala Ser Glu Pro Gln 
        115                 120                 125     


<210>  27
<211>  127
<212>  PRT
<213>  Lama glama

<400>  27

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Arg Ala Phe Arg Thr Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Arg Met Thr Phe Gly Gly Gly Asp Thr Asp Tyr Ala Gly Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Tyr Ala Lys Asn Ile Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Thr Tyr Arg Asp Leu Leu Gln Ser Arg Thr Val Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala His His 
        115                 120                 125         


<210>  28
<211>  120
<212>  PRT
<213>  Lama glama

<400>  28

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Asp Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Thr Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Ala Leu Gly Thr Gly Gln Gly Asn Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Glu Pro Gln 
        115                 120 


<210>  29
<211>  120
<212>  PRT
<213>  Lama glama

<400>  29

Glu Val Lys Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Asp Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Thr Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Ala Leu Gly Thr Gly Arg Gly Asn Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Glu Pro Gln 
        115                 120 


<210>  30
<211>  122
<212>  PRT
<213>  Lama glama

<400>  30

Gln Val Lys Leu Gln Glu Ser Gly Gly Asp Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Pro Tyr Val Met 
            20                  25                  30          


Gly Trp Phe Arg Gln Ala Arg Gly Lys Glu Arg Glu Phe Val Ala Ala 
        35                  40                  45              


Ile Thr Ser Ser Phe Thr Arg Tyr Leu Ala Asp Ser Val Lys Gly Arg 
    50                  55                  60                  


Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Gln Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Gly 
                85                  90                  95      


Ser Ile Val Arg Pro Ser Thr Asp Ala Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Glu Pro Gln 
        115                 120         


<210>  31
<211>  118
<212>  PRT
<213>  Lama glama

<400>  31

Gln Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Gly Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Ser Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Leu Gly Thr Gly Arg Ala Asn Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser Glu Pro Gln 
        115             


<210>  32
<211>  118
<212>  PRT
<213>  Lama glama

<400>  32

Gln Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Gly Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln His Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Ser Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Leu Gly Thr Gly Arg Ala Asn Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser Glu Pro Gln 
        115             


<210>  33
<211>  118
<212>  PRT
<213>  Lama glama

<400>  33

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Gly Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Ser Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Leu Gly Thr Gly Arg Ala Asn Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser Glu Pro Gln 
        115             


<210>  34
<211>  120
<212>  PRT
<213>  Lama glama

<400>  34

Glu Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Asp Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Ala Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Ala Leu Gly Thr Gly Arg Gly Asn Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Glu Pro Gln 
        115                 120 


<210>  35
<211>  118
<212>  PRT
<213>  Lama glama

<400>  35

Glu Val Lys Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Gly Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Ser Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Leu Gly Thr Gly Arg Ala Asn Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser Glu Pro Gln 
        115             


<210>  36
<211>  120
<212>  PRT
<213>  Lama glama

<400>  36

Glu Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Ala Ser Asp Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Thr Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Thr Ala 
65                  70                  75                  80  


Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Ala Leu Gly Thr Gly Arg Ala Asn Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Glu Pro Gln 
        115                 120 


<210>  37
<211>  120
<212>  PRT
<213>  Lama glama

<400>  37

Gln Val Lys Leu His Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Asp Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Thr Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Ala Leu Gly Thr Gly Arg Gly Asn Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Glu Pro Gln 
        115                 120 


<210>  38
<211>  120
<212>  PRT
<213>  Lama glama

<400>  38

Glu Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Asp Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Thr Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Ala Leu Gly Thr Gly Arg Ala Asn Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Glu Pro Gln 
        115                 120 


<210>  39
<211>  120
<212>  PRT
<213>  Lama glama

<400>  39

Glu Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Asp Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Thr Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Ala Leu Gly Thr Gly Arg Ala Asn Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Glu Pro Gln 
        115                 120 


<210>  40
<211>  120
<212>  PRT
<213>  Lama glama

<400>  40

Glu Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Asp Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Thr Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Ala Leu Gly Thr Gly Arg Gly Asn Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Glu Pro Gln 
        115                 120 


<210>  41
<211>  120
<212>  PRT
<213>  Lama glama

<400>  41

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Asp Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Thr Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Ala Leu Gly Thr Gly Arg Gly Asn Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Glu Pro Gln 
        115                 120 


<210>  42
<211>  118
<212>  PRT
<213>  Lama glama

<400>  42

Glu Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Gly Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Ser Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Leu Gly Thr Gly Arg Ala Asn Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser Glu Pro Gln 
        115             


<210>  43
<211>  118
<212>  PRT
<213>  Lama glama

<400>  43

Glu Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Gly Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Ser Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Asp Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Leu Gly Thr Gly Arg Ala Asn Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser Glu Pro Gln 
        115             


<210>  44
<211>  120
<212>  PRT
<213>  Lama glama

<400>  44

Glu Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Asp Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Thr Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Thr Val 
65                  70                  75                  80  


Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Asn Ala Leu Gly Thr Gly Arg Ala Asn Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Glu Pro Gln 
        115                 120 


<210>  45
<211>  118
<212>  PRT
<213>  Lama glama

<400>  45

Glu Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Ser Thr Val Ser Gly Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Ser Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Leu Gly Thr Gly Arg Ala Asn Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser Glu Pro Gln 
        115             


<210>  46
<211>  118
<212>  PRT
<213>  Lama glama

<400>  46

Gln Val Lys Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Asn Thr Val Ser Gly Asn 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Val Gly Val Ser Asn Val Ala Gln Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Leu Gly Thr Gly Arg Ala Asn Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser Gly Pro Gln 
        115             


<210>  47
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random Phage used as Negative Control

<400>  47

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ser Asn Glu 
            20                  25                  30          


Pro Phe Gly Trp Tyr Arg Gly Ala Pro Gly Lys Leu Arg Glu Leu Val 
        35                  40                  45              


Gly Thr Ile Ser Ala Gly Gly Asn Thr Asn Tyr Val Asp Ala Val Lys 
    50                  55                  60                  


Gly Arg Phe Met Ile Ser Arg Asp Asn Gly Arg Arg Met Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Arg Pro Asp Asp Thr Ala Val Tyr Tyr Cys Trp 
                85                  90                  95      


Asn Arg Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Glu 
            100                 105                 110         


Pro Gln 
        


<210>  48
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Random Phage used as Negative Control

<400>  48

Lys Val Lys Leu Gln Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Leu Glu Ser Ser 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Ser Glu Arg Glu Glu Val 
        35                  40                  45              


Ser Cys Ile Ser Thr Lys Gly Asn Ile Lys Asp Thr Pro Ser Val Arg 
    50                  55                  60                  


Gly Arg Phe Thr Val Ser Arg Asp Asn Val Lys Asn Ile Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Ser Cys Trp Gln His Ile Asp Gly Ile Leu Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Glu Pro Gln 
        115                 120     


<210>  49
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-His and Myc tag

<400>  49

Thr Pro Lys Pro Gln Pro Gln Pro Gln Pro Ala Ala Ala His His His 
1               5                   10                  15      


His His His Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
            20                  25                  30          


Asn Gly Ala Ala 
        35      


<210>  50
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-His and Myc tags

<400>  50

Ser Glu Asp Pro Ser Ser Ala Ala Ala His His His His His His Gly 
1               5                   10                  15      


Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Ala Ala 
            20                  25                  30          


<210>  51
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  51
catgccatga ctcgcggccc agccggccat ggccsaggts marctgcags agtcwgg          57


<210>  52
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  52
ttttcctttt gcggccgcgg ccgcggagct ggggtcttcg ctgtggtgcg                  50


<210>  53
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  53
ggattgggtt gcggccgctg gttgtggttg tggttgtggt tttggtgtct ggggttc          57


