                         SEQUENCE LISTING

<110>  Baylor College of Medicine
       Wang, Rong-Fu
       Wang, Helen Y.
       Cui, Jun
       Zhu, Liang
 
<120>  NLRC5 AS A TARGET FOR IMMUNE THERAPY

<130>  HO-P03629US0

<140>  TBA
<141>  2009-10-06

<150>  61/102,967
<151>  2008-10-06

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  23
<212>  DNA
<213>  siRNA; Artificial synthetic; where N is any nucleotide


<220>
<221>  misc_feature
<222>  (3)..(21)
<223>  n is a, c, g, t or u

<400>  1
aannnnnnnn nnnnnnnnnn ntt                                               23


<210>  2
<211>  1744
<212>  PRT
<213>  Dog

<400>  2

Met Ala Phe Thr Phe Leu Lys Val Leu Asn Asn Met Glu Ile Asp Thr 
1               5                   10                  15      


Ser Leu Phe Asp Glu Val Gly Ala Lys Ile Ile Lys Asp Leu Met Ser 
            20                  25                  30          


Lys Ala Glu Lys Asn Gly Val Lys Ile Ile Leu Pro Val Asp Phe Val 
        35                  40                  45              


Thr Ala Glu Lys Phe Asp Glu His Ala Arg Thr Gly Gln Ala Thr Val 
    50                  55                  60                  


Ala Ser Gly Ile Pro Ala Gly Trp Met Gly Leu Asp Cys Gly Pro Glu 
65                  70                  75                  80  


Ser Ser Lys Lys Tyr Ala Glu Ala Val Ala Trp Ala Lys Gln Ile Met 
                85                  90                  95      


Trp Asn Gly Pro Val Gly Val Ser Glu Trp Glu Ala Leu Ala Arg Gly 
            100                 105                 110         


Thr Lys Ala Leu Met Asp Glu Val Val Lys Ala Thr Ala Trp Asp Cys 
        115                 120                 125             


Ile Thr Ile Ile Gly Gly Gly Asp Ile Ala Ile Cys Cys Val Lys Trp 
    130                 135                 140                 


Asn Thr Glu Asp Lys Val Ser His Gly Gln Leu Leu Met Asp His Val 
145                 150                 155                 160 


Ser Phe Gln Leu Gly Thr Thr Asn Leu Trp Ser Trp Leu Val Arg Leu 
                165                 170                 175     


Leu Ser Lys Asp Pro Glu Trp Leu Asn Ala Lys Val Lys Phe Phe Leu 
            180                 185                 190         


Pro Lys Met Asp Leu Ser Ser Gly Asp Glu Ala Gln Asp Thr Thr Gln 
        195                 200                 205             


Arg Val Met Leu Gln Leu Arg Arg Leu His Thr Gln Gly Arg Ala Thr 
    210                 215                 220                 


Trp Gln Ala Phe Ile His Cys Val Cys Met Glu Leu Asp Val Pro Leu 
225                 230                 235                 240 


Asp Leu Glu Val Pro Leu Leu Ser Thr Trp Gly His Gly Asp Gly Leu 
                245                 250                 255     


Lys Arg Pro His Gln Ser Cys Gly Ser Ser Pro Arg Leu Lys Gln Cys 
            260                 265                 270         


Lys Asn His Gln Leu Glu Leu Ala Arg Arg Tyr Leu Lys Leu Leu Arg 
        275                 280                 285             


Thr Ser Ala Gln Gln Arg Tyr Ser Arg Ile Pro Gly Pro Gly Gln Pro 
    290                 295                 300                 


Leu Ala Phe His Gln Ala Tyr Ile Pro Pro Ile Leu Gln Trp Ser Arg 
305                 310                 315                 320 


Thr Thr Ala Pro Phe Ser Ala Gln Asp Gly Ala Val Val Gly Asp Pro 
                325                 330                 335     


Lys Ala Glu Asp Asp Thr Asp Val Ser Ile Arg Asp Leu Phe Ser Thr 
            340                 345                 350         


Arg Ala Asp Lys Gly Pro Arg Val Thr Val Leu Leu Gly Lys Ala Gly 
        355                 360                 365             


Met Gly Lys Thr Thr Leu Ala His Arg Leu Cys Gln Arg Trp Ala Ala 
    370                 375                 380                 


Gly Gln Leu Asp Arg Phe Gln Ala Leu Phe Leu Phe Glu Phe Arg Gln 
385                 390                 395                 400 


Leu Asn Leu Ile Thr Ser Ser Val Thr Leu Pro Gln Leu Leu Phe Asp 
                405                 410                 415     


Leu Tyr Leu Ser Pro Glu Ala Gly Pro Asp Ser Val Phe Gln Tyr Leu 
            420                 425                 430         


Glu Glu His Ala Gly Gly Val Leu Leu Ile Phe Asp Gly Leu Asp Gln 
        435                 440                 445             


Ala Leu His Ser His Ser Ser Thr Glu Pro Glu Gly Pro Glu Ala Pro 
    450                 455                 460                 


Ser Pro Ala Leu Ala Leu Phe Ser Gly Leu Cys Arg Gly Thr Ile Leu 
465                 470                 475                 480 


Pro Gly Cys Trp Val Leu Ala Thr Ser Arg Pro Gly Lys Leu Pro Asp 
                485                 490                 495     


Cys Leu Pro Thr Glu Ala Ala Thr Val His Met Trp Gly Phe Asp Arg 
            500                 505                 510         


Pro Arg Val Glu Glu Tyr Val Gly Arg Phe Phe Ser Asp Gln Glu Trp 
        515                 520                 525             


Gln Glu Ala Ala Leu Ala Glu Leu Arg Glu Asn Arg His Leu Gln Ser 
    530                 535                 540                 


Met Cys Ala Val Pro Ala Leu Cys Gln Val Thr Cys Leu Cys Leu His 
545                 550                 555                 560 


His Leu Leu Pro Gly Asn Ser Pro Gly Gln Ser Ala Ala Leu Leu Pro 
                565                 570                 575     


Thr Val Thr Gln Asn Tyr Val Gln Met Val Ser Thr Leu Ser Pro Arg 
            580                 585                 590         


Gly Tyr Leu Pro Pro Glu Ser Leu Leu Gly Leu Ser Glu Met Ala Leu 
        595                 600                 605             


Arg Gly Leu Glu Thr Gly Lys Val Ile Phe Ser Val Gly Asp Ile Ser 
    610                 615                 620                 


Pro Pro Met Val Ala Phe Gly Ala Ala Leu Gly Leu Leu Thr Ser Phe 
625                 630                 635                 640 


Cys Ile Cys Thr Gly Pro Gly His Gln Gly Ile Gly Tyr Ala Phe Thr 
                645                 650                 655     


His Leu Ser Leu Gln Glu Phe Phe Ala Ala Leu Tyr Leu Met Ala Ser 
            660                 665                 670         


Pro Lys Val Asp Lys Asn Val Leu Ala Arg His Val Thr Leu Asn Ser 
        675                 680                 685             


Arg Trp Val Leu Arg Thr Lys Ala Arg Leu Gly Leu Leu Asp His Leu 
    690                 695                 700                 


Pro Thr Phe Leu Ala Gly Leu Ala Ser Cys Ala Cys Arg Pro Phe Leu 
705                 710                 715                 720 


Ser His Val Ala Gln Gln Asp Glu Met Trp Val Ser Asp Lys Gln Ala 
                725                 730                 735     


Ala Val Met Leu Ala Leu Arg Lys Leu Ala Ile Arg Arg Leu Thr Gly 
            740                 745                 750         


Pro Lys Val Val Ala Leu Cys His Cys Val Gly Glu Thr Gln Glu Pro 
        755                 760                 765             


Glu Leu Ala Ser Leu Met Ala Gln Ser Leu Pro Ser His Leu Ser Phe 
    770                 775                 780                 


His Asn Phe Pro Leu Thr Tyr Thr Asp Leu Ser Ala Leu Thr Asn Ile 
785                 790                 795                 800 


Leu Arg His Arg Asn Ala Ser Ile His Leu Asp Phe Glu Gly Cys Pro 
                805                 810                 815     


Leu Glu Pro His Cys Pro Glu Ala Leu Ala Gly Cys Lys Gln Ile Glu 
            820                 825                 830         


Asn Leu Ser Phe Lys Ser Arg Lys Cys Gly Asp Ala Phe Ala Glu Ala 
        835                 840                 845             


Leu Ser Lys Ser Leu Pro Thr Met Glu Ser Leu Lys Lys Leu Gly Leu 
    850                 855                 860                 


Ala Gly Cys Lys Ile Thr Ala Arg Gly Ile Ser His Leu Met Gln Ala 
865                 870                 875                 880 


Leu Arg Leu Cys Pro Gln Leu Glu Glu Ile Ser Phe Gln Asp Asn Gln 
                885                 890                 895     


Leu Lys Asp Arg Ala Val Leu Asn Ile Val Glu Val Leu Pro Ser Leu 
            900                 905                 910         


Pro Arg Leu Gln Lys Leu Asp Leu Ser Arg Ser Asn Val Ser Val Ser 
        915                 920                 925             


Thr Leu Leu Cys Leu Thr Lys Val Ala Val Thr Cys Pro Thr Val Lys 
    930                 935                 940                 


Met Leu Gln Val Arg Leu Leu Gln Cys Gln Leu Gly Ile His Asp Val 
945                 950                 955                 960 


Gln Glu Leu Ile Ala Gln Leu Arg Glu Gly Pro Arg Leu Glu Glu Val 
                965                 970                 975     


Asn Leu Ser Asn Asn Gly Leu Ser Val Asp Arg Val His Cys Met Leu 
            980                 985                 990         


Ser Ala Val Asn Thr Cys Gln Asn  Leu Ala Glu Leu His  Ile Ser Leu 
        995                 1000                 1005             


Leu His  Lys Thr Val Val Phe  Thr Phe Ala Pro Glu  Gln Glu Glu 
    1010                 1015                 1020             


Gln Glu  Gly Ile Trp Lys Arg  Thr Ala Leu Arg Asp  Ser Leu Thr 
    1025                 1030                 1035             


His Gln  Val Pro Phe Glu Leu  Pro Leu Arg Ser Thr  Arg Ile Ser 
    1040                 1045                 1050             


Leu Ser  Gly Asn Ala Leu Gly  Asp Glu Gly Val Ala  Gln Leu Ala 
    1055                 1060                 1065             


Gln Leu  Leu Pro Gly Leu Gly  Ala Leu Gln Ser Leu  Asn Phe Glu 
    1070                 1075                 1080             


Ser Gln  His Val Val Leu Arg  Gly Asp Arg Arg Gly  Ser Leu Arg 
    1085                 1090                 1095             


Gln Cys  Gln Leu Glu Pro Leu  Asn Leu Thr Arg Leu  Cys Glu Thr 
    1100                 1105                 1110             


Leu Glu  Lys Cys Pro Gly Pro  Leu Glu Val Glu Leu  Ser Phe Glu 
    1115                 1120                 1125             


Val Leu  Ser Asp Gln Ser Leu  Glu Thr Leu Leu Gln  His Leu Pro 
    1130                 1135                 1140             


Arg Leu  Pro Gln Leu Ser Leu  Leu Gln Leu Ser Gln  Thr Arg Leu 
    1145                 1150                 1155             


Ser Pro  Lys Ser Leu Leu Leu  Leu Ala Asp Leu Phe  Ser Leu Cys 
    1160                 1165                 1170             


Pro Arg  Val Gln Lys Val Asp  Ile Arg Ser Leu Tyr  His Met Thr 
    1175                 1180                 1185             


Leu His  Phe Arg Ser Gly Glu  Glu His Glu Gly Glu  Cys Cys Gly 
    1190                 1195                 1200             


Phe Thr  Gly Cys Gly Leu Ser  Gln Glu His Val Glu  Pro Leu Cys 
    1205                 1210                 1215             


Trp Leu  Leu Ser Lys Cys Glu  Asp Leu Asn Gln Leu  Asp Leu Ser 
    1220                 1225                 1230             


His Asn  Ser Ile Ser Leu Glu  Ser Ala Leu Gly Leu  Val Lys Thr 
    1235                 1240                 1245             


Leu Pro  Ser Cys Pro His Ile  Arg Glu Ala Ser Val  Lys Ala Arg 
    1250                 1255                 1260             


Glu Ala  Gly Pro Pro Thr Ser  Pro His Pro Cys Leu  Cys Ser Leu 
    1265                 1270                 1275             


Gly Ser  Glu Gln Ser Phe Trp  Ile Tyr Phe Ser Arg  Lys Glu Glu 
    1280                 1285                 1290             


Ala Gly  Lys Thr Leu Arg Leu  Ser Gln Cys Asn Leu  Met Pro Glu 
    1295                 1300                 1305             


His Val  Pro Arg Leu Ala Thr  His Leu Asn Gln Ala  Leu Lys Leu 
    1310                 1315                 1320             


Thr Ala  Leu Thr Leu Thr Gln  Cys Gly Leu Gly Leu  Glu Gln Leu 
    1325                 1330                 1335             


Ile Val  Leu Leu Ser Leu Leu  Arg Cys Pro Val Asp  Leu Phe Thr 
    1340                 1345                 1350             


Leu Arg  Val Glu Glu Pro Trp  Val Gly Lys Ala Gly  Val Leu Ala 
    1355                 1360                 1365             


Leu Leu  Arg Val Cys Thr Gln  Thr Ser Gly Asn Ile  Thr Glu Ile 
    1370                 1375                 1380             


Ser Ile  Ser Glu Thr Gln Gln  Gln Leu Cys Leu Gln  Leu Glu Phe 
    1385                 1390                 1395             


Pro Pro  Gln Glu Asn Pro Glu  Ala Val Thr Leu Arg  Leu Ala His 
    1400                 1405                 1410             


Cys Asp  Leu Glu Thr His His  Ser Leu Leu Ala Gly  Gln Leu Met 
    1415                 1420                 1425             


Glu Thr  Cys Ala Arg Leu Gln  Gln Leu Ser Leu Ser  Gln Val Asn 
    1430                 1435                 1440             


Leu Cys  Asp Ser Ser Ser Leu  Leu Leu Lys Asn Leu  Leu Val Ser 
    1445                 1450                 1455             


Leu Ser  Glu Leu Lys Thr Phe  Arg Leu Thr Ser Ser  Cys Met Ser 
    1460                 1465                 1470             


Ser Lys  Gly Leu Ala His Leu  Thr Phe Gly Leu Arg  Asn Cys His 
    1475                 1480                 1485             


His Leu  Glu Glu Leu Asp Leu  Ser Asn Asn Gln Phe  Gly Glu Glu 
    1490                 1495                 1500             


Asp Thr  Glu Val Leu Met Thr  Val Leu Glu Gly Lys  Cys Trp Leu 
    1505                 1510                 1515             


Lys Lys  Leu Asp Leu Ser His  Leu Pro Leu Gly Ser  Ser Thr Leu 
    1520                 1525                 1530             


Ala Met  Phe Thr Gln Gly Leu  Ser His Met Thr Leu  Leu Gln Ser 
    1535                 1540                 1545             


Leu Arg  Leu Ser Arg Asn Gly  Ile Cys Asp Val Gly  Cys His Gln 
    1550                 1555                 1560             


Leu Ser  Glu Ala Leu Arg Ala  Ala Met Ser Leu Lys  Glu Leu Gly 
    1565                 1570                 1575             


Leu Gly  Tyr Asn Val Leu Gly  Asp Thr Thr Ala Leu  Gly Leu Ala 
    1580                 1585                 1590             


Gln Gly  Leu Pro Cys Cys Leu  Arg Val Leu His Leu  Pro Ser Ser 
    1595                 1600                 1605             


Arg Leu  Gly Pro Lys Gly Ala  Leu Ser Leu Ser Gln  Ala Leu Asp 
    1610                 1615                 1620             


Gly Cys  Pro His Val Glu Glu  Ile Ser Leu Val Ser  Cys Glu Ile 
    1625                 1630                 1635             


Asp Asn  His Thr Ala Lys Pro  Leu Ala Ala Ser Leu  Val Leu Cys 
    1640                 1645                 1650             


Pro Ala  Leu Glu Glu Ile Leu  Leu Ser Trp Asn Leu  Leu Gly Asp 
    1655                 1660                 1665             


Glu Ala  Ala Ala Glu Leu Ala  Arg Val Leu Pro Gln  Met Gly Arg 
    1670                 1675                 1680             


Leu Lys  Arg Met Asp Leu Glu  Lys Asn Arg Ile Thr  Ala Cys Gly 
    1685                 1690                 1695             


Ala Trp  Leu Leu Ala Glu Gly  Leu Ala Gln Gly Ser  Gly Ile Gln 
    1700                 1705                 1710             


Val Ile  Arg Leu Trp Asn Asn  Pro Ile Ser Pro Thr  Met Val Gln 
    1715                 1720                 1725             


His Leu  Gln Ser Gln Glu Pro  Arg Leu Asp Phe Ala  Phe Phe Asp 
    1730                 1735                 1740             


Lys 
    


<210>  3
<211>  1868
<212>  PRT
<213>  Bull

<400>  3

Met Asp Pro Val Ser Leu Gln Leu Gly Thr Lys Asn Leu His Gly Tyr 
1               5                   10                  15      


Leu Val Arg Leu Leu Ser Arg Asn Leu Gly Trp Leu Asp Ala Lys Val 
            20                  25                  30          


Lys Leu Phe Leu Pro Ser Val Asp Leu Gly Ser Gly Tyr Gln Ala Leu 
        35                  40                  45              


Asp Pro Thr Gln Arg Val Ile Leu Gln Leu Gln Lys Leu His Ala Gln 
    50                  55                  60                  


Gly Pro Thr Thr Trp Lys Ser Phe Ile Gln Cys Val Cys Met Glu Leu 
65                  70                  75                  80  


Asp Val Pro Met Asp Met Glu Val Leu Leu Met Ser Thr Trp Gly His 
                85                  90                  95      


Glu Asp Gly Phe Ser Ser Leu Leu Glu Ile Asp Glu Glu Ser Gln Ser 
            100                 105                 110         


Asp Ser Gln Leu His Pro Gly Leu Lys Arg Thr His Gln Ser Cys Gly 
        115                 120                 125             


Ser Ser Pro Arg Pro Lys Gln Phe Arg Lys Gln Gln Gln Glu Leu Ala 
    130                 135                 140                 


Lys Arg Tyr Leu Gln Leu Leu Arg Thr Ser Ala Gln Gln Arg Tyr Gly 
145                 150                 155                 160 


Asn Arg Thr Pro Gly Pro Gly Gln Pro Leu Ala Phe His Gln Ala Tyr 
                165                 170                 175     


Val Pro Pro Ile Leu Lys Trp Ser Arg Ala Ser Ala Pro Phe His Thr 
            180                 185                 190         


Gln Glu Gly Ala Thr Thr Gly Asn Pro Lys Ala Glu Asp Gly Thr Asp 
        195                 200                 205             


Val Asn Val Arg Asp Leu Phe Ser Thr Lys Ala Ser Lys Gly Pro Arg 
    210                 215                 220                 


Val Thr Val Leu Leu Gly Lys Ala Gly Met Gly Lys Thr Thr Leu Ala 
225                 230                 235                 240 


His Arg Leu Cys Gln Lys Trp Ala Asp Gly Gln Leu Asp Arg Phe Gln 
                245                 250                 255     


Ala Val Phe Leu Phe Glu Phe Arg Gln Leu Asn Leu Ile Thr Gly Ser 
            260                 265                 270         


Leu Thr Leu Pro Gln Leu Leu Phe Asp Met Tyr Leu Arg Pro Glu Ala 
        275                 280                 285             


Ser Pro Glu Ala Val Phe Gln His Leu Lys Glu Asn Ala Glu Gly Ile 
    290                 295                 300                 


Leu Leu Ile Phe Asp Gly Leu Asp Glu Ile Leu Gln Pro Cys Ser Asp 
305                 310                 315                 320 


Lys Glu Thr Glu Asp Pro Glu Asp Pro Ala Ser Ala Leu Thr Leu Phe 
                325                 330                 335     


Ser Arg Leu Cys Arg Gly Thr Leu Leu Pro Gly Cys Ser Val Met Ala 
            340                 345                 350         


Thr Ser Arg Pro Gly Lys Leu Pro Ala Cys Leu Pro Thr Glu Ala Ala 
        355                 360                 365             


Thr Val His Met Trp Gly Phe Asp Gly Pro Arg Val Glu Glu Tyr Val 
    370                 375                 380                 


Asn His Phe Phe Ser Asp Gln Pro Ser Gln Glu Ala Ala Leu Ala Glu 
385                 390                 395                 400 


Leu Gln Met Asp Arg His Leu Trp Ser Met Cys Ala Val Pro Ala Leu 
                405                 410                 415     


Cys Arg Val Ala Cys Leu Cys Leu His His Leu Leu Pro Gly Arg Ser 
            420                 425                 430         


Arg Gly Gln Ser Ala Ala Leu Leu Pro Thr Met Thr Gln Asn Tyr Met 
        435                 440                 445             


Gln Met Leu Leu Thr Leu Asn Pro Gln Gly Val Leu Arg Ala Glu Pro 
    450                 455                 460                 


Leu Leu Gly Leu Gly Glu Val Ala Leu Ser Gly Leu Glu Ser Gly Lys 
465                 470                 475                 480 


Val Ile Phe Ser Ala Gly Asp Ile Pro Ala Ser Thr Leu Asp Phe Gly 
                485                 490                 495     


Ala Ala Leu Gly Leu Leu Thr Ser Phe Cys Val Cys Leu Gly Pro Gly 
            500                 505                 510         


His Arg Asp Thr Gly Tyr Ala Phe Ser His Leu Ser Leu Gln Glu Phe 
        515                 520                 525             


Phe Ala Ala Leu His Leu Leu Ala Ser Pro Gln Val Asp Arg Glu Ala 
    530                 535                 540                 


Leu Ser Gln His Val Thr Leu His Ser Arg Trp Val Gln Arg Thr Lys 
545                 550                 555                 560 


Ala Arg Leu Gly Leu Ser Asp His Leu Pro Thr Phe Leu Ala Gly Leu 
                565                 570                 575     


Ala Ser Arg Ala Cys Arg Ser Phe Leu Ser Leu Leu Ala Glu Arg Glu 
            580                 585                 590         


Glu Glu Trp Val Ala Ala Lys Gln Glu Val Val Leu Gln Ala Leu Lys 
        595                 600                 605             


Lys Leu Ala Thr Arg Arg Leu Thr Gly Pro Lys Val Val Glu Leu Cys 
    610                 615                 620                 


His Arg Val Gly Glu Thr Gln Asp Pro Glu Leu Ala Ser Phe Met Ala 
625                 630                 635                 640 


Arg Ser Leu Pro Gln Gln Leu Pro Phe His Asn Phe Leu Leu Thr Tyr 
                645                 650                 655     


Ala Asp Leu Ala Ser Leu Thr Ser Ile Leu Gly His Arg Asp Gly Pro 
            660                 665                 670         


Ile His Leu Asp Phe Glu Gly Cys Pro Leu Glu Pro Arg Cys Pro Glu 
        675                 680                 685             


Thr Leu Ala Gly Cys Gly Gln Val Glu Asn Leu Ser Phe Lys Ser Arg 
    690                 695                 700                 


Lys Cys Gly Asp Ala Phe Ala Glu Ala Leu Ser Lys Ser Leu Pro Thr 
705                 710                 715                 720 


Met Gly Ser Leu Lys Lys Leu Gly Leu Ala Gly Ser Lys Ile Thr Ala 
                725                 730                 735     


Gln Gly Ile Ser His Leu Val Gln Ala Leu Pro Phe Cys Pro Gln Leu 
            740                 745                 750         


Glu Glu Val Ser Phe Gln Asp Asn Gln Leu Lys Asp Arg Glu Val Leu 
        755                 760                 765             


Asn Ile Val Glu Val Leu Ser Cys Leu Pro Arg Leu Gln Lys Leu Asp 
    770                 775                 780                 


Leu Ser Arg Asn Asn Val Ser Val Ser Thr Leu Leu Ser Leu Thr Lys 
785                 790                 795                 800 


Val Ala Val Thr Cys Pro Thr Ile Arg Met Leu Gln Val Arg Glu Thr 
                805                 810                 815     


Asp Leu Ile Phe Leu Leu Ser Pro Pro Thr Glu Thr Asp Pro Glu Leu 
            820                 825                 830         


Gln Gly Asp Pro Asp Leu Gln Gly Asn Ala Asn Gln Arg Lys Glu Ala 
        835                 840                 845             


Gln Arg Arg Ser Leu Ala Leu Arg Leu Gln Lys Cys Gln Leu Gly Val 
    850                 855                 860                 


His Asp Val Glu Val Leu Ile Ala Gln Leu Arg Glu Gly Pro Gln Leu 
865                 870                 875                 880 


Asp Glu Val Asp Leu Ser Gly Asn Gln Leu Lys Asp Lys Gly Cys Gln 
                885                 890                 895     


Leu Met Ala Glu Ala Ala Pro Gln Leu His Ile Thr Lys Lys Leu Asp 
            900                 905                 910         


Leu Ser Asp Asn Glu Leu Ser Val Ala Gly Val Leu Gly Val Leu Ser 
        915                 920                 925             


Val Val Asn Thr Tyr Gln Thr Leu Thr Glu Leu His Ile Ser Leu Leu 
    930                 935                 940                 


His Lys Thr Val Val Phe Thr Phe Ala Pro Glu Leu Glu Glu Gln Glu 
945                 950                 955                 960 


Gly Ile Gln Lys Arg Ala Thr Phe Pro Asp Ser Leu Met Phe Gln Met 
                965                 970                 975     


Ser Ser Glu Pro Ser Leu Arg Ser Pro Arg Ile Arg Leu Thr His Cys 
            980                 985                 990         


Ala Leu Gln Ala Gln Arg Leu Glu  Leu Leu Cys Lys Ala  Leu Gly Gly 
        995                 1000                 1005             


Ser Cys  Arg Leu Ser His Leu  Asp Leu Ser Gly Asn  Ala Leu Gly 
    1010                 1015                 1020             


Asp Glu  Gly Val Ala Leu Leu  Ala Arg Leu Leu Pro  Gly Leu Gly 
    1025                 1030                 1035             


Ser Leu  Gln Ser Leu Asn Leu  Ser Glu Asn His Leu  Ser Leu Glu 
    1040                 1045                 1050             


Gly Val  Cys Ser Leu Thr Gln  Cys Phe Ser Thr Leu  Arg Trp Leu 
    1055                 1060                 1065             


Leu His  Leu Glu Phe Ser Ser  Ala Ser Gln His Val  Ile Leu Arg 
    1070                 1075                 1080             


Gly Asp  Lys Arg Gly Arg Asp  Leu Leu Ala Ala Gly  Ser Leu Pro 
    1085                 1090                 1095             


Glu Phe  Arg Ala Gly Ala Arg  Leu Gly Ser Gly Gln  Arg His Val 
    1100                 1105                 1110             


Pro Arg  Ser Phe Cys Leu Lys  Glu Cys Gln Leu Glu  Pro Leu Ser 
    1115                 1120                 1125             


Leu Ser  Tyr Leu Cys Lys Ser  Leu Glu Lys Cys Pro  Gly Pro Leu 
    1130                 1135                 1140             


Glu Val  Gln Leu Ser Cys Glu  Val Leu Ser Asp Gln  Ser Leu Glu 
    1145                 1150                 1155             


Thr Leu  Leu Tyr His Leu Pro  Gln Leu Pro Gln Leu  Ser Leu Leu 
    1160                 1165                 1170             


Gln Leu  Ser Gln Met Gln Leu  Pro Pro Glu Ser Pro  Leu Leu Leu 
    1175                 1180                 1185             


Ala Asp  Leu Phe Ser Leu Cys  Pro Gln Val Gln Lys  Val Asp Leu 
    1190                 1195                 1200             


Arg Ser  Leu Arg His Leu Thr  Leu His Leu Arg Ser  Ser Glu Glu 
    1205                 1210                 1215             


Gln Glu  Asp Arg Cys Cys Trp  Arg Phe Thr Asp Cys  Gly Leu Arg 
    1220                 1225                 1230             


Gln Glu  His Val Glu Pro Leu  Cys Gly Leu Leu Ser  Lys Cys Glu 
    1235                 1240                 1245             


Asp Leu  His Gln Leu Asp Leu  Ser Ala Asn Leu Leu  Gly Asp Asp 
    1250                 1255                 1260             


Gly Leu  Arg Cys Leu Leu Glu  Cys Leu Pro Lys Val  Pro Ile Ser 
    1265                 1270                 1275             


Gly Ser  Leu Asp Leu Ser His  Asn Ser Met Ser Gln  Glu Ser Val 
    1280                 1285                 1290             


Leu Cys  Leu Val Glu Ala Leu  Pro Ser Cys Pro Arg  Leu Arg Glu 
    1295                 1300                 1305             


Ala Ser  Val Asn Leu Gly Ser  Lys Gln Ser Phe Trp  Ile His Phe 
    1310                 1315                 1320             


Ser Arg  Gln Glu Glu Thr Gly  Lys Thr Leu Arg Leu  Ser Glu Cys 
    1325                 1330                 1335             


His Phe  Lys Pro Glu His Met  Pro Arg Leu Ala Ala  Ser Leu Ser 
    1340                 1345                 1350             


Gln Ala  Leu Gln Leu Thr Glu  Leu Thr Leu Thr Trp  Cys Phe Pro 
    1355                 1360                 1365             


Gly Leu  Glu Gln Leu Thr Val  Leu Leu Gly Leu Leu  Thr Trp Pro 
    1370                 1375                 1380             


Thr Gly  Val Leu Thr Leu Arg  Val Glu Glu Pro Trp  Val Gly Arg 
    1385                 1390                 1395             


Val Gly  Val Leu Thr Leu Leu  Glu Val Cys Ala Gln  Ala Ser Gly 
    1400                 1405                 1410             


Asn Ile  Thr Gly Ile Ser Ile  Ser Glu Thr Gln Lys  Gln Leu Cys 
    1415                 1420                 1425             


Ile Gln  Leu Glu Phe Pro His  Gln Glu Asn Pro Glu  Ala Val Ala 
    1430                 1435                 1440             


Leu Arg  Leu Ala His Cys Asp  Leu Gly Thr Gln Gln  Asn Leu Leu 
    1445                 1450                 1455             


Ala Arg  Lys Leu Met Glu Thr  Cys Ala Arg Leu Arg  Gln Leu Ser 
    1460                 1465                 1470             


Leu Ser  Gln Val Asn Leu Cys  Asp Ala Ser Ser Leu  Leu Leu Gln 
    1475                 1480                 1485             


Ser Leu  Leu Leu Ser Leu Ser  Glu Leu Lys Asn Phe  Arg Leu Thr 
    1490                 1495                 1500             


Ser Ser  Cys Val Ser Ser Lys  Gly Leu Ala Leu Leu  Thr Ser Gly 
    1505                 1510                 1515             


Leu Ser  His Cys His Leu Leu  Glu Glu Leu Asp Leu  Ser Asn Asn 
    1520                 1525                 1530             


Gln Leu  Gly Asp Glu Gly Thr  Lys Val Leu Leu Gly  Ala Leu Glu 
    1535                 1540                 1545             


Gly Lys  Cys Arg Leu Lys Arg  Leu Asp Leu Ser His  Leu Pro Leu 
    1550                 1555                 1560             


Gly Gly  Ser Thr Leu Ala Val  Leu Thr Gln Gly Leu  Gly His Met 
    1565                 1570                 1575             


Thr Leu  Leu Gln Ser Leu Arg  Leu Ser Lys Ser Asn  Ile Asp Asp 
    1580                 1585                 1590             


Val Gly  Cys Cys His Leu Ser  Lys Ala Leu Arg Ala  Ala Thr Ser 
    1595                 1600                 1605             


Leu Glu  Glu Leu Ser Leu Ser  His Asn Gln Ile Gly  Asn Ile Gly 
    1610                 1615                 1620             


Ala Gln  Asp Leu Ala Ala Val  Leu Pro Gly Leu Pro  Glu Leu Arg 
    1625                 1630                 1635             


Lys Ile  Asp Leu Ser Ala Asn  Gly Ile Gly Pro Ala  Gly Gly Ala 
    1640                 1645                 1650             


Arg Leu  Ala Glu Ser Leu Thr  Leu Cys Arg His Leu  Glu Glu Leu 
    1655                 1660                 1665             


Met Leu  Gly Cys Asn Ala Leu  Gly Asp Cys Thr Ala  Leu Gly Leu 
    1670                 1675                 1680             


Ala Lys  Gly Leu Pro Gln His  Leu Arg Val Leu His  Leu Pro Ser 
    1685                 1690                 1695             


Ser His  Leu Ser Pro Glu Gly  Val Leu Ser Leu Gly  Gln Ala Leu 
    1700                 1705                 1710             


Asp Gly  Cys Pro His Val Glu  Glu Ile Ser Leu Ala  Glu Asn Ser 
    1715                 1720                 1725             


Leu Ala  Gly Gly Val Pro His  Phe His Gln Gly Phe  Pro Val Leu 
    1730                 1735                 1740             


Arg Lys  Leu Asp Leu Val Ser  Cys Glu Ile Asp Asn  Gln Thr Ala 
    1745                 1750                 1755             


Lys Pro  Leu Ala Ala Ser Phe  Val Leu Cys Leu Ala  Leu Glu Glu 
    1760                 1765                 1770             


Ile Thr  Leu Ser Trp Asn Leu  Leu Gly Asp Glu Ala  Ala Ala Glu 
    1775                 1780                 1785             


Leu Ala  Arg Val Leu Pro Gln  Met Gly Arg Leu Lys  Arg Met Asp 
    1790                 1795                 1800             


Leu Glu  Lys Asn Gln Ile Thr  Ala Tyr Gly Ala Trp  Leu Leu Ala 
    1805                 1810                 1815             


Glu Gly  Leu Ala Gln Gly Ser  Gly Ile Gln Val Ile  Arg Leu Trp 
    1820                 1825                 1830             


Asn Asn  Arg Ile Pro Pro Asp  Met Ala Gln His Leu  Gln Asn Gln 
    1835                 1840                 1845             


Glu Pro  Arg Leu Asp Phe Ala  Phe Phe Asp Asn Gln  Pro Gln Val 
    1850                 1855                 1860             


Ile Pro  Arg Gly Thr 
    1865             


<210>  4
<211>  1840
<212>  PRT
<213>  Horse

<400>  4

Met Asp Pro Asp Ser Leu Gln Leu Gly Thr Lys Ser Leu Trp Ser Trp 
1               5                   10                  15      


Leu Val Arg Leu Leu Ser Gln Ala Pro Glu Trp Met Asn Ala Lys Val 
            20                  25                  30          


Lys Phe Phe Leu Pro Asn Met Asp Leu Gly Ser Arg Ser Glu Ala Leu 
        35                  40                  45              


Asp Pro Ser Gln Arg Ile Ile Gln Gln Leu Arg Glu Leu Tyr Ala Gln 
    50                  55                  60                  


Gly Pro Ala Pro Trp Gln Thr Phe Ile His Cys Val Cys Met Glu Leu 
65                  70                  75                  80  


Glu Val Pro Leu Glu Leu Glu Val Pro Leu Leu Ser Thr Trp Gly His 
                85                  90                  95      


Gly Asp Gly Phe Pro Ser Pro Leu Glu Ala Gly Glu Asp Cys Gly Pro 
            100                 105                 110         


Glu Ser Gln Leu Gln His Gly Ile Lys Arg Pro His Gln Ser Cys Gly 
        115                 120                 125             


Ser Ser Pro Arg Pro Lys Gln Ser Arg Lys Gln Gln Leu Glu Leu Ala 
    130                 135                 140                 


Lys Arg Tyr Leu Lys Leu Leu Arg Ser Ser Ala Gln Gln Arg Tyr Gly 
145                 150                 155                 160 


Gly Arg Ile Leu Gly Pro Gly Gln Pro Leu Val Phe Pro Gln Ala Tyr 
                165                 170                 175     


Val Pro Pro Val Leu Gln Trp Ser Arg Ala Thr Ala Pro Phe Ser Thr 
            180                 185                 190         


Gln Glu Gly Ala Leu Met Gly Asp Pro Lys Ala Glu Asp Gly Thr Asp 
        195                 200                 205             


Val Ser Ile Leu Asp Leu Leu Asn Thr Arg Ala Asp Lys Gly Pro Arg 
    210                 215                 220                 


Val Arg Val Leu Leu Gly Lys Ala Gly Met Gly Lys Thr Thr Leu Ala 
225                 230                 235                 240 


His Trp Leu Cys Gln Lys Trp Ala Asp Gly Gln Leu Asp Arg Phe Gln 
                245                 250                 255     


Ala Leu Phe Leu Phe Glu Phe Arg Gln Leu Asn Leu Ile Thr Ser Val 
            260                 265                 270         


Leu Thr Leu Pro Gln Leu Leu Phe Asp Leu Tyr Leu Ser Pro Glu Glu 
        275                 280                 285             


Gly Pro Asp Ala Val Phe Glu Tyr Leu Glu Asp Asn Ala Asn Gly Val 
    290                 295                 300                 


Leu Leu Ile Phe Asp Gly Leu Asp Glu Ala Leu Gln Pro Cys Ser Ser 
305                 310                 315                 320 


Gly Glu Thr Val Asp Pro Glu Ala Leu Gly Pro Ala Leu Thr Leu Phe 
                325                 330                 335     


Ser Asp Leu Cys Arg Gly Thr Leu Leu Pro Gly Cys Trp Val Met Ala 
            340                 345                 350         


Thr Ser Arg Pro Gly Lys Leu Pro Ala Cys Val Pro Thr Glu Ala Ala 
        355                 360                 365             


Thr Val His Met Trp Gly Phe Asp Arg Pro Arg Val Glu Glu Phe Val 
    370                 375                 380                 


Gly Arg Phe Phe Ser Asp Leu Pro Ser Gln Lys Ala Ala Leu Ala Glu 
385                 390                 395                 400 


Leu Arg Ala Asn Arg Arg Leu Arg Ser Leu Cys Ala Val Pro Ala Leu 
                405                 410                 415     


Cys Arg Val Thr Cys Val Cys Leu His His Leu Leu Pro Gly Ser Ser 
            420                 425                 430         


Pro Gly Gln Ser Ala Ala Leu Leu Pro Thr Met Thr Gln Thr Tyr Val 
        435                 440                 445             


Gln Met Met Leu Ala Leu Arg Pro Arg Gly Tyr Leu Pro Ala Asn Ser 
    450                 455                 460                 


Leu Met Gly Leu Cys Glu Val Ala Leu Ser Gly Leu Glu Thr Gly Lys 
465                 470                 475                 480 


Val Ile Phe Ser Ala Arg Asp Ile Pro Pro Ala Thr Leu Ala Phe Gly 
                485                 490                 495     


Ala Ala His Gly Leu Leu Ile Ser Phe Cys Ile Cys Ile Ser Pro Gly 
            500                 505                 510         


Arg Gln Glu Thr Gly Tyr Ala Phe Pro Tyr Leu Ser Leu Gln Glu Phe 
        515                 520                 525             


Phe Ala Ala Leu His Leu Met Ala Ser Pro Glu Val Asp Gln Asp Ala 
    530                 535                 540                 


Leu Ala Arg His Val Thr Leu Asn Ser Arg Trp Val Leu Arg Thr Lys 
545                 550                 555                 560 


Ala Arg Leu Gly Leu Ser Asp His Leu Pro Ala Phe Leu Ser Gly Leu 
                565                 570                 575     


Ala Ser Cys Ala Cys Arg His Phe Leu Ser Gln Leu Ala Gln Arg Asp 
            580                 585                 590         


Glu Val Trp Val Ser Ala Lys Gln Ala Ala Val Ala Gln Ala Leu Arg 
        595                 600                 605             


Lys Leu Ala Thr Arg Arg Leu Thr Gly Pro Lys Val Val Glu Leu Cys 
    610                 615                 620                 


His Cys Val Ser Glu Thr Gln Glu Ser Glu Leu Ala Gly Leu Val Ala 
625                 630                 635                 640 


Gln Ser Leu Pro Tyr Gln Leu Gln Phe His Asn Phe Pro Leu Thr His 
                645                 650                 655     


Ala Asp Leu Ala Ala Val Thr Asn Ile Leu Gly His Arg Asp Ala Pro 
            660                 665                 670         


Val His Leu Asn Phe Glu Gly Cys Pro Leu Glu Pro Ser Cys Pro Glu 
        675                 680                 685             


Ala Leu Ala Ser Cys Gly Gln Val Glu Ser Leu Ser Phe Lys Ser Arg 
    690                 695                 700                 


Lys Cys Gly Asp Ala Phe Ala Glu Ala Leu Ser Arg Ser Leu Pro Thr 
705                 710                 715                 720 


Met Gly Ser Leu Lys Lys Leu Gly Leu Ala Gly Ser Lys Ile Thr Ala 
                725                 730                 735     


Arg Gly Ile Ser His Val Val Gln Ala Leu Ser Leu Cys Pro Gln Leu 
            740                 745                 750         


Glu Glu Val Ser Phe Gln Asp Asn Gln Leu Lys Asp Gln Glu Val Leu 
        755                 760                 765             


Ser Ile Val Lys Ile Leu Pro Arg Leu Pro His Leu Arg Lys Leu Asp 
    770                 775                 780                 


Leu Ser Arg Asn His Val Ser Asp Trp Thr Leu Leu His Leu Thr Glu 
785                 790                 795                 800 


Val Ala Val Thr Cys Pro Thr Val Arg Met Leu Gln Val Thr Lys Ala 
                805                 810                 815     


Asp Leu Ile Phe Leu Leu Ser Pro Pro Ala Glu Thr Ala Ala Glu Leu 
            820                 825                 830         


Pro Gly Ala Pro Asp Leu Gln Glu Ser Ala Ser Ser Arg Lys Glu Ala 
        835                 840                 845             


Gln Ser Arg Ser Leu Thr Leu Arg Leu Gln Glu Cys Gln Leu Gly Val 
    850                 855                 860                 


His Glu Val Glu Met Leu Leu Ala Gln Leu Arg Lys Gly Pro His Leu 
865                 870                 875                 880 


Asp Glu Val Asp Leu Ser Gly Asn Gln Leu Glu Asp Glu Gly Cys Arg 
                885                 890                 895     


Leu Met Ala Glu Ala Ala Pro Gln Leu His Ile Thr Arg Lys Leu Asp 
            900                 905                 910         


Leu Ser Asp Asn Gly Leu Ser Met Ala Gly Leu Tyr Arg Val Leu Gly 
        915                 920                 925             


Ala Ala Ser Thr Cys Arg Thr Leu Ala Glu Leu His Ile Ser Leu Leu 
    930                 935                 940                 


His Lys Thr Val Val Leu Thr Phe Ala Pro Glu Pro Glu Glu Gln Ala 
945                 950                 955                 960 


Gly Met Gln Arg Arg Ala Val Phe Pro Asp Ser His Val Pro Gln Thr 
                965                 970                 975     


Pro Ser Glu Leu Pro Leu Arg Ser Gln Arg Ile Arg Leu Ala His Cys 
            980                 985                 990         


Gly Leu Gln Ala Lys His Leu Glu  Leu Leu Cys Lys Ala  Leu Glu Gly 
        995                 1000                 1005             


Ser His  His Leu Gly His Leu  Asp Leu Ser Ser Asn  Ala Leu Gly 
    1010                 1015                 1020             


Asp Glu  Gly Ala Ala Gln Leu  Ala Gln Leu Leu Pro  Gly Leu Gly 
    1025                 1030                 1035             


Pro Leu  Gln Ser Leu Asn Leu  Ser Glu Asn Gly Leu  Ser Pro Asp 
    1040                 1045                 1050             


Ala Gly  Phe Ser Leu Ala Leu  Cys Phe Ser Thr Val  Gln Trp Val 
    1055                 1060                 1065             


Leu His  Leu Asp Ile Thr Gly  Glu Ser Gln Arg Ile  Val Leu Gly 
    1070                 1075                 1080             


Gly Ala  Gly Arg Gly Arg Asp  Leu Ser Ala Ala Gly  Ser Val Pro 
    1085                 1090                 1095             


Glu Leu  Pro Ala Gly Ala Glu  Phe Leu Gly Ser Gly  Gln Arg Cys 
    1100                 1105                 1110             


Val Pro  Arg Ser Phe Cys Leu  Ser Glu Cys Gln Leu  Glu Pro Leu 
    1115                 1120                 1125             


Ser Leu  Thr Arg Leu Cys Asp  Thr Leu Glu Lys Cys  Pro Gly Pro 
    1130                 1135                 1140             


Leu Glu  Val Thr Leu Ser Cys  Lys Gly Leu Ser Asp  Gln Ser Leu 
    1145                 1150                 1155             


Glu Thr  Leu Leu His Arg Leu  Pro Arg Leu Pro Gln  Leu Ser Arg 
    1160                 1165                 1170             


Leu Arg  Leu Ser Gln Thr Ala  Leu Ser Pro Arg Ser  Pro Leu Ile 
    1175                 1180                 1185             


Leu Ala  Asp Val Phe Ser Leu  Cys Pro Arg Val Gln  Lys Val Asp 
    1190                 1195                 1200             


Leu Gln  Ser Leu Cys His Thr  Thr Leu His Phe Arg  Ser Ser Glu 
    1205                 1210                 1215             


Glu Gln  Glu Gly Gly Cys Cys  Gly Leu Ser Ala Asn  Gln Leu Gly 
    1220                 1225                 1230             


Asp Ala  Gly Leu Gln Cys Leu  Leu Glu His Leu Pro  Arg Val Pro 
    1235                 1240                 1245             


Ile Ser  Gly Ser Leu Asp Leu  Ser His Asn Arg Leu  Ser Gln Glu 
    1250                 1255                 1260             


Ser Ala  Leu Cys Leu Val Glu  Thr Leu Pro Ser Cys  Pro Arg Ile 
    1265                 1270                 1275             


Arg Glu  Ala Ser Val Asn Leu  Gly Leu Arg Ala Glu  Leu Leu Gly 
    1280                 1285                 1290             


Phe Thr  Ser Pro His Arg Arg  Arg Leu Glu Lys Thr  Leu Arg Leu 
    1295                 1300                 1305             


Thr Glu  Cys His Phe Arg Pro  Glu His Val Pro Arg  Leu Ala Ser 
    1310                 1315                 1320             


Gly Leu  Ser Gln Ala Pro Gln  Leu Ala Glu Leu Thr  Leu Thr Gln 
    1325                 1330                 1335             


Cys Cys  Leu Gly Leu Glu Gln  Leu Thr Val Leu Leu  Ser Leu Val 
    1340                 1345                 1350             


Arg Trp  Pro Arg Gly Leu Leu  Ser Leu Arg Val Glu  Glu Pro Trp 
    1355                 1360                 1365             


Val Gly  Arg Ala Gly Val Leu  Thr Leu Pro Glu Val  Cys Ala Gln 
    1370                 1375                 1380             


Ala Ser  Gly Asn Val Thr Lys  Ile Ser Ile Ser Glu  Thr Gln Gln 
    1385                 1390                 1395             


Gln Leu  Cys Val Gln Leu Glu  Phe Pro Arg Gln Glu  Asn Pro Gly 
    1400                 1405                 1410             


Ala Val  Pro Leu Arg Leu Ala  His Cys Asp Leu Gly  Thr His Arg 
    1415                 1420                 1425             


Ser Leu  Leu Val Arg Gln Leu  Met Glu Thr Cys Ala  Arg Leu Arg 
    1430                 1435                 1440             


Gln Leu  Ser Leu Ser Gln Val  Asn Leu Cys Asp Ala  Ser Ser Leu 
    1445                 1450                 1455             


Leu Leu  Glu Asn Leu Leu Leu  Ser Val Ser Glu Leu  Lys Thr Phe 
    1460                 1465                 1470             


Arg Leu  Ile Ser Ser Arg Val  Ser Ser Glu Gly Leu  Ala His Leu 
    1475                 1480                 1485             


Thr Ser  Gly Leu Ser His Cys  Pro His Leu Glu Glu  Leu Glu Leu 
    1490                 1495                 1500             


Ser Asn  Thr Gln Phe Gly Glu  Glu Asp Thr Lys Val  Leu Met Gly 
    1505                 1510                 1515             


Ala Leu  Glu Gly Lys Arg Arg  Leu Lys Arg Leu Asn  Leu Ser His 
    1520                 1525                 1530             


Leu Pro  Leu Gly Gly Ser Ser  Leu Ala Val Leu Thr  Gln Gly Leu 
    1535                 1540                 1545             


Ser Arg  Met Ile Leu Leu Gln  Ser Leu Arg Leu Ser  Ser Asn Gly 
    1550                 1555                 1560             


Ile Ser  Asp Ile Gly Cys Cys  His Leu Ser Lys Ala  Leu Arg Ala 
    1565                 1570                 1575             


Val Thr  Ser Leu Glu Glu Leu  Gly Leu Ser His Asn  Gln Ile Gly 
    1580                 1585                 1590             


Asp Thr  Gly Ala Gln His Leu  Ala Ala Val Leu Pro  Gly Leu Pro 
    1595                 1600                 1605             


Glu Leu  Arg Lys Ile Asp Leu  Ser Ala Asn Gly Ile  Gly Pro Ala 
    1610                 1615                 1620             


Gly Gly  Met Arg Leu Val Glu  Ser Leu Ala Leu Cys  Thr His Leu 
    1625                 1630                 1635             


Glu Glu  Leu Met Leu Gly Cys  Asn Ala Leu Gly Asp  Pro Thr Ala 
    1640                 1645                 1650             


Leu Arg  Leu Ala Gln Ala Leu  Pro Pro His Leu Arg  Val Leu His 
    1655                 1660                 1665             


Leu Pro  Ser Ser Arg Leu Gly  Pro Glu Gly Ala Leu  Ser Leu Ala 
    1670                 1675                 1680             


Arg Ala  Leu Asp Arg Cys Pro  Gln Val Glu Val Ile  Ser Leu Ala 
    1685                 1690                 1695             


Glu Asn  Ser Leu Ala Gly Gly  Val Pro His Phe Cys  Gln Gly Leu 
    1700                 1705                 1710             


Pro Leu  Leu Arg Gln Ile Asp  Leu Val Ser Cys Glu  Ile Asp Asp 
    1715                 1720                 1725             


Gln Thr  Ala Lys Pro Leu Ala  Ala Gly Phe Met Leu  Cys Pro Ala 
    1730                 1735                 1740             


Leu Glu  Glu Ile Leu Leu Ser  Trp Asn Leu Leu Gly  Asp Glu Ala 
    1745                 1750                 1755             


Ala Ala  Glu Leu Ala Arg Val  Leu Pro Arg Met Gly  Arg Leu Lys 
    1760                 1765                 1770             


Arg Val  Asp Leu Glu Lys Asn  Arg Ile Thr Ala Cys  Gly Ala Trp 
    1775                 1780                 1785             


Leu Leu  Ala Glu Gly Leu Ala  Gln Gly Ser Gly Ile  Gln Val Ile 
    1790                 1795                 1800             


Arg Leu  Trp Asn Asn Leu Ile  Pro Thr Asp Met Ala  Gln Arg Leu 
    1805                 1810                 1815             


Gln Ser  Gln Glu Pro Arg Leu  Asp Phe Ala Phe Phe  His Asn Gln 
    1820                 1825                 1830             


Pro Pro  Ala Pro Arg Gly Thr  
    1835                 1840 


<210>  5
<211>  1866
<212>  PRT
<213>  Human

<400>  5

Met Asp Pro Val Gly Leu Gln Leu Gly Asn Lys Asn Leu Trp Ser Cys 
1               5                   10                  15      


Leu Val Arg Leu Leu Thr Lys Asp Pro Glu Trp Leu Asn Ala Lys Met 
            20                  25                  30          


Lys Phe Phe Leu Pro Asn Thr Asp Leu Asp Ser Arg Asn Glu Thr Leu 
        35                  40                  45              


Asp Pro Glu Gln Arg Val Ile Leu Gln Leu Asn Lys Leu His Val Gln 
    50                  55                  60                  


Gly Ser Asp Thr Trp Gln Ser Phe Ile His Cys Val Cys Met Gln Leu 
65                  70                  75                  80  


Glu Val Pro Leu Asp Leu Glu Val Leu Leu Leu Ser Thr Phe Gly Tyr 
                85                  90                  95      


Asp Asp Gly Phe Thr Ser Gln Leu Gly Ala Glu Gly Lys Ser Gln Pro 
            100                 105                 110         


Glu Ser Gln Leu His His Gly Leu Lys Arg Pro His Gln Ser Cys Gly 
        115                 120                 125             


Ser Ser Pro Arg Arg Lys Gln Cys Lys Lys Gln Gln Leu Glu Leu Ala 
    130                 135                 140                 


Lys Lys Tyr Leu Gln Leu Leu Arg Thr Ser Ala Gln Gln Arg Tyr Arg 
145                 150                 155                 160 


Ser Gln Ile Pro Gly Ser Gly Gln Pro His Ala Phe His Gln Val Tyr 
                165                 170                 175     


Val Pro Pro Ile Leu Arg Arg Ala Thr Ala Ser Leu Asp Thr Pro Glu 
            180                 185                 190         


Gly Ala Ile Met Gly Asp Val Lys Val Glu Asp Gly Ala Asp Val Ser 
        195                 200                 205             


Ile Ser Asp Leu Phe Asn Thr Arg Val Asn Lys Gly Pro Arg Val Thr 
    210                 215                 220                 


Val Leu Leu Gly Lys Ala Gly Met Gly Lys Thr Thr Leu Ala His Arg 
225                 230                 235                 240 


Leu Cys Gln Lys Trp Ala Glu Gly His Leu Asn Cys Phe Gln Ala Leu 
                245                 250                 255     


Phe Leu Phe Glu Phe Arg Gln Leu Asn Leu Ile Thr Arg Phe Leu Thr 
            260                 265                 270         


Pro Ser Glu Leu Leu Phe Asp Leu Tyr Leu Ser Pro Glu Ser Asp His 
        275                 280                 285             


Asp Thr Val Phe Gln Tyr Leu Glu Lys Asn Ala Asp Gln Val Leu Leu 
    290                 295                 300                 


Ile Phe Asp Gly Leu Asp Glu Ala Leu Gln Pro Met Gly Pro Asp Gly 
305                 310                 315                 320 


Pro Gly Pro Val Leu Thr Leu Phe Ser His Leu Cys Asn Gly Thr Leu 
                325                 330                 335     


Leu Pro Gly Cys Arg Val Met Ala Thr Ser Arg Pro Gly Lys Leu Pro 
            340                 345                 350         


Ala Cys Leu Pro Ala Glu Ala Ala Met Val His Met Leu Gly Phe Asp 
        355                 360                 365             


Gly Pro Arg Val Glu Glu Tyr Val Asn His Phe Phe Ser Ala Gln Pro 
    370                 375                 380                 


Ser Arg Glu Gly Ala Leu Val Glu Leu Gln Thr Asn Gly Arg Leu Arg 
385                 390                 395                 400 


Ser Leu Cys Ala Val Pro Ala Leu Cys Gln Val Ala Cys Leu Cys Leu 
                405                 410                 415     


His His Leu Leu Pro Asp His Ala Pro Gly Gln Ser Val Ala Leu Leu 
            420                 425                 430         


Pro Asn Met Thr Gln Leu Tyr Met Gln Met Val Leu Ala Leu Ser Pro 
        435                 440                 445             


Pro Gly His Leu Pro Thr Ser Ser Leu Leu Asp Leu Gly Glu Val Ala 
    450                 455                 460                 


Leu Arg Gly Leu Glu Thr Gly Lys Val Ile Phe Tyr Ala Lys Asp Ile 
465                 470                 475                 480 


Ala Pro Pro Leu Ile Ala Phe Gly Ala Thr His Ser Leu Leu Thr Ser 
                485                 490                 495     


Phe Cys Val Cys Thr Gly Pro Gly His Gln Gln Thr Gly Tyr Ala Phe 
            500                 505                 510         


Thr His Leu Ser Leu Gln Glu Phe Leu Ala Ala Leu His Leu Met Ala 
        515                 520                 525             


Ser Pro Lys Val Asn Lys Asp Thr Leu Thr Gln Tyr Val Thr Leu His 
    530                 535                 540                 


Ser Arg Trp Val Gln Arg Thr Lys Ala Arg Leu Gly Leu Ser Asp His 
545                 550                 555                 560 


Leu Pro Thr Phe Leu Ala Gly Leu Ala Ser Cys Thr Cys Arg Pro Phe 
                565                 570                 575     


Leu Ser His Leu Ala Gln Gly Asn Glu Asp Cys Val Gly Ala Lys Gln 
            580                 585                 590         


Ala Ala Val Val Gln Val Leu Lys Lys Leu Ala Thr Arg Lys Leu Thr 
        595                 600                 605             


Gly Pro Lys Val Val Glu Leu Cys His Cys Val Asp Glu Thr Gln Glu 
    610                 615                 620                 


Pro Glu Leu Ala Ser Leu Thr Ala Gln Ser Leu Pro Tyr Gln Leu Pro 
625                 630                 635                 640 


Phe His Asn Phe Pro Leu Thr Cys Thr Asp Leu Ala Thr Leu Thr Asn 
                645                 650                 655     


Ile Leu Glu His Arg Glu Ala Pro Ile His Leu Asp Phe Asp Gly Cys 
            660                 665                 670         


Pro Leu Glu Pro His Cys Pro Glu Ala Leu Val Gly Cys Gly Gln Ile 
        675                 680                 685             


Glu Asn Leu Ser Phe Lys Ser Arg Lys Cys Gly Asp Ala Phe Ala Glu 
    690                 695                 700                 


Ala Leu Ser Arg Ser Leu Pro Thr Met Gly Arg Leu Gln Met Leu Gly 
705                 710                 715                 720 


Leu Ala Gly Ser Lys Ile Thr Ala Arg Gly Ile Ser His Leu Val Lys 
                725                 730                 735     


Ala Leu Pro Leu Cys Pro Gln Leu Lys Glu Val Ser Phe Arg Asp Asn 
            740                 745                 750         


Gln Leu Ser Asp Gln Val Val Leu Asn Ile Val Glu Val Leu Pro His 
        755                 760                 765             


Leu Pro Arg Leu Arg Lys Leu Asp Leu Ser Ser Asn Ser Ile Cys Val 
    770                 775                 780                 


Ser Thr Leu Leu Cys Leu Ala Arg Val Ala Val Thr Cys Pro Thr Val 
785                 790                 795                 800 


Arg Met Leu Gln Ala Arg Glu Ala Asp Leu Ile Phe Leu Leu Ser Pro 
                805                 810                 815     


Pro Thr Glu Thr Thr Ala Glu Leu Gln Arg Ala Pro Asp Leu Gln Glu 
            820                 825                 830         


Ser Asp Gly Gln Arg Lys Gly Ala Gln Ser Arg Ser Leu Thr Leu Arg 
        835                 840                 845             


Leu Gln Lys Cys Gln Leu Gln Val His Asp Ala Glu Ala Leu Ile Ala 
    850                 855                 860                 


Leu Leu Gln Glu Gly Pro His Leu Glu Glu Val Asp Leu Ser Gly Asn 
865                 870                 875                 880 


Gln Leu Glu Asp Glu Gly Cys Arg Leu Met Ala Glu Ala Ala Ser Gln 
                885                 890                 895     


Leu His Ile Ala Arg Lys Leu Asp Leu Ser Asp Asn Gly Leu Ser Val 
            900                 905                 910         


Ala Gly Val His Cys Val Leu Arg Ala Val Ser Ala Cys Trp Thr Leu 
        915                 920                 925             


Ala Glu Leu His Ile Ser Leu Gln His Lys Thr Val Ile Phe Met Phe 
    930                 935                 940                 


Ala Gln Glu Pro Glu Glu Gln Lys Gly Pro Gln Glu Arg Ala Ala Phe 
945                 950                 955                 960 


Leu Asp Ser Leu Met Leu Gln Met Pro Ser Glu Leu Pro Leu Ser Ser 
                965                 970                 975     


Arg Arg Met Arg Leu Thr His Cys Gly Leu Gln Glu Lys His Leu Glu 
            980                 985                 990         


Gln Leu Cys Lys Ala Leu Gly Gly  Ser Cys His Leu Gly  His Leu His 
        995                 1000                 1005             


Leu Asp  Phe Ser Gly Asn Ala  Leu Gly Asp Glu Gly  Ala Ala Arg 
    1010                 1015                 1020             


Leu Ala  Gln Leu Leu Pro Gly  Leu Gly Ala Leu Gln  Ser Leu Asn 
    1025                 1030                 1035             


Leu Ser  Glu Asn Gly Leu Ser  Leu Asp Ala Val Leu  Gly Leu Val 
    1040                 1045                 1050             


Arg Cys  Phe Ser Thr Leu Gln  Trp Leu Phe Arg Leu  Asp Ile Ser 
    1055                 1060                 1065             


Phe Glu  Ser Gln His Ile Leu  Leu Arg Gly Asp Lys  Thr Ser Arg 
    1070                 1075                 1080             


Asp Met  Trp Ala Thr Gly Ser  Leu Pro Asp Phe Pro  Ala Ala Ala 
    1085                 1090                 1095             


Lys Phe  Leu Gly Phe Arg Gln  Arg Cys Ile Pro Arg  Ser Leu Cys 
    1100                 1105                 1110             


Leu Ser  Glu Cys Pro Leu Glu  Pro Pro Ser Leu Thr  Arg Leu Cys 
    1115                 1120                 1125             


Ala Thr  Leu Lys Asp Cys Pro  Gly Pro Leu Glu Leu  Gln Leu Ser 
    1130                 1135                 1140             


Cys Glu  Phe Leu Ser Asp Gln  Ser Leu Glu Thr Leu  Leu Asp Cys 
    1145                 1150                 1155             


Leu Pro  Gln Leu Pro Gln Leu  Ser Leu Leu Gln Leu  Ser Gln Thr 
    1160                 1165                 1170             


Gly Leu  Ser Pro Lys Ser Pro  Phe Leu Leu Ala Asn  Thr Leu Ser 
    1175                 1180                 1185             


Leu Cys  Pro Arg Val Lys Lys  Val Asp Leu Arg Ser  Leu His His 
    1190                 1195                 1200             


Ala Thr  Leu His Phe Arg Ser  Asn Glu Glu Glu Glu  Gly Val Cys 
    1205                 1210                 1215             


Cys Gly  Arg Phe Thr Gly Cys  Ser Leu Ser Gln Glu  His Val Glu 
    1220                 1225                 1230             


Ser Leu  Cys Trp Leu Leu Ser  Lys Cys Lys Asp Leu  Ser Gln Val 
    1235                 1240                 1245             


Asp Leu  Ser Ala Asn Leu Leu  Gly Asp Ser Gly Leu  Arg Cys Leu 
    1250                 1255                 1260             


Leu Glu  Cys Leu Pro Gln Val  Pro Ile Ser Gly Leu  Leu Asp Leu 
    1265                 1270                 1275             


Ser His  Asn Ser Ile Ser Gln  Glu Ser Ala Leu Tyr  Leu Leu Glu 
    1280                 1285                 1290             


Thr Leu  Pro Ser Cys Pro Arg  Val Arg Glu Ala Ser  Val Asn Leu 
    1295                 1300                 1305             


Gly Ser  Glu Gln Ser Phe Arg  Ile His Phe Ser Arg  Glu Asp Gln 
    1310                 1315                 1320             


Ala Gly  Lys Thr Leu Arg Leu  Ser Glu Cys Ser Phe  Arg Pro Glu 
    1325                 1330                 1335             


His Val  Ser Arg Leu Ala Thr  Gly Leu Ser Lys Ser  Leu Gln Leu 
    1340                 1345                 1350             


Thr Glu  Leu Thr Leu Thr Gln  Cys Cys Leu Gly Gln  Lys Gln Leu 
    1355                 1360                 1365             


Ala Ile  Leu Leu Ser Leu Val  Gly Arg Pro Ala Gly  Leu Phe Ser 
    1370                 1375                 1380             


Leu Arg  Val Gln Glu Pro Trp  Ala Asp Arg Ala Arg  Val Leu Ser 
    1385                 1390                 1395             


Leu Leu  Glu Val Cys Ala Gln  Ala Ser Gly Ser Val  Thr Glu Ile 
    1400                 1405                 1410             


Ser Ile  Ser Glu Thr Gln Gln  Gln Leu Cys Val Gln  Leu Glu Phe 
    1415                 1420                 1425             


Pro Arg  Gln Glu Glu Asn Pro  Glu Ala Val Ala Leu  Arg Leu Ala 
    1430                 1435                 1440             


His Cys  Asp Leu Gly Ala His  His Ser Leu Leu Val  Gly Gln Leu 
    1445                 1450                 1455             


Met Glu  Thr Cys Ala Arg Leu  Gln Gln Leu Ser Leu  Ser Gln Val 
    1460                 1465                 1470             


Asn Leu  Cys Glu Asp Asp Asp  Ala Ser Ser Leu Leu  Leu Gln Ser 
    1475                 1480                 1485             


Leu Leu  Leu Ser Leu Ser Glu  Leu Lys Thr Phe Arg  Leu Thr Ser 
    1490                 1495                 1500             


Ser Cys  Val Ser Thr Glu Gly  Leu Ala His Leu Ala  Ser Gly Leu 
    1505                 1510                 1515             


Gly His  Cys His His Leu Glu  Glu Leu Asp Leu Ser  Asn Asn Gln 
    1520                 1525                 1530             


Phe Asp  Glu Glu Gly Thr Lys  Ala Leu Met Arg Ala  Leu Glu Gly 
    1535                 1540                 1545             


Lys Trp  Met Leu Lys Arg Leu  Asp Leu Ser His Leu  Leu Leu Asn 
    1550                 1555                 1560             


Ser Ser  Thr Leu Ala Leu Leu  Thr His Arg Leu Ser  Gln Met Thr 
    1565                 1570                 1575             


Cys Leu  Gln Ser Leu Arg Leu  Asn Arg Asn Ser Ile  Gly Asp Val 
    1580                 1585                 1590             


Gly Cys  Cys His Leu Ser Glu  Ala Leu Arg Ala Ala  Thr Ser Leu 
    1595                 1600                 1605             


Glu Glu  Leu Asp Leu Ser His  Asn Gln Ile Gly Asp  Ala Gly Val 
    1610                 1615                 1620             


Gln His  Leu Ala Thr Ile Leu  Pro Gly Leu Pro Glu  Leu Arg Lys 
    1625                 1630                 1635             


Ile Asp  Leu Ser Gly Asn Ser  Ile Ser Ser Ala Gly  Gly Val Gln 
    1640                 1645                 1650             


Leu Ala  Glu Ser Leu Val Leu  Cys Arg Arg Leu Glu  Glu Leu Met 
    1655                 1660                 1665             


Leu Gly  Cys Asn Ala Leu Gly  Asp Pro Thr Ala Leu  Gly Leu Ala 
    1670                 1675                 1680             


Gln Glu  Leu Pro Gln His Leu  Arg Val Leu His Leu  Pro Phe Ser 
    1685                 1690                 1695             


His Leu  Gly Pro Gly Gly Ala  Leu Ser Leu Ala Gln  Ala Leu Asp 
    1700                 1705                 1710             


Gly Ser  Pro His Leu Glu Glu  Ile Ser Leu Ala Glu  Asn Asn Leu 
    1715                 1720                 1725             


Ala Gly  Gly Val Leu Arg Phe  Cys Met Glu Leu Pro  Leu Leu Arg 
    1730                 1735                 1740             


Gln Ile  Asp Leu Val Ser Cys  Lys Ile Asp Asn Gln  Thr Ala Lys 
    1745                 1750                 1755             


Leu Leu  Thr Ser Ser Phe Thr  Ser Cys Pro Ala Leu  Glu Val Ile 
    1760                 1765                 1770             


Leu Leu  Ser Trp Asn Leu Leu  Gly Asp Glu Ala Ala  Ala Glu Leu 
    1775                 1780                 1785             


Ala Gln  Val Leu Pro Gln Met  Gly Arg Leu Lys Arg  Val Asp Leu 
    1790                 1795                 1800             


Glu Lys  Asn Gln Ile Thr Ala  Leu Gly Ala Trp Leu  Leu Ala Glu 
    1805                 1810                 1815             


Gly Leu  Ala Gln Gly Ser Ser  Ile Gln Val Ile Arg  Leu Trp Asn 
    1820                 1825                 1830             


Asn Pro  Ile Pro Cys Asp Met  Ala Gln His Leu Lys  Ser Gln Glu 
    1835                 1840                 1845             


Pro Arg  Leu Asp Phe Ala Phe  Phe Asp Asn Gln Pro  Gln Ala Pro 
    1850                 1855                 1860             


Trp Gly  Thr 
    1865     


<210>  6
<211>  1748
<212>  PRT
<213>  Chicken

<400>  6

Met Gln Pro Thr Leu Gln Asn Asp Asp Phe Asn Leu Glu Gly Ala Val 
1               5                   10                  15      


Ala Ser Ile Arg Pro Gln Leu Val Glu Phe Leu Ser His Arg Leu Asp 
            20                  25                  30          


Trp Leu Leu Ser Ala Ser Gln His Phe Leu Pro Thr Ala Val Leu Ser 
        35                  40                  45              


Gly Leu Ala Gly Val Thr Asp His Arg Glu Lys Val Ser Val Leu Leu 
    50                  55                  60                  


Asp Leu Leu Glu Lys Ala Gly His Ala Thr Trp Lys Gln Phe Ala Gln 
65                  70                  75                  80  


Cys Leu Cys Met Glu Cys Asp Leu Pro Leu Glu Met Glu Ile Leu Leu 
                85                  90                  95      


Met Ser Ser Ala Gly Glu Gly Asn Leu Thr Gln Lys Gln Glu Ala Gln 
            100                 105                 110         


Thr Asp Ala Ser Asp Gln Ser Ser Val Pro Arg Gly Leu Thr Arg Arg 
        115                 120                 125             


Arg Arg Ser Ser Ser Pro Ile Ser Asp Lys Gly Ala Lys Gln Lys Arg 
    130                 135                 140                 


Leu Asp Ser Ala Glu Lys Tyr Gln Arg Leu Leu Val Asp Ser Ile Cys 
145                 150                 155                 160 


Lys Arg Tyr Gly Ser Arg Arg Ala Ala Gly Ala Ala Ala Gln Glu Pro 
                165                 170                 175     


Thr Gln Pro Leu Ala Phe Ser Gln Ala Phe Val Asn Leu Val Leu Arg 
            180                 185                 190         


Gln Ser Lys Ala Ser Arg Leu Lys Glu Arg Thr Asp Lys Pro Arg Glu 
        195                 200                 205             


Asp Val Pro Ser Ala Pro Glu Pro Glu Glu Cys Val Asp Thr Ala Val 
    210                 215                 220                 


Arg Val Ser Asp Leu Phe Gly Ser Val Val Arg Ser Gly Thr Thr Lys 
225                 230                 235                 240 


Val Ile Phe Leu Phe Gly Lys Pro Gly Thr Gly Lys Thr Met Leu Met 
                245                 250                 255     


His Arg Ile Cys Gln Lys Trp Ala Glu Gly Val Leu His Gln Phe Leu 
            260                 265                 270         


Phe Thr Phe Leu Phe Glu Phe Arg Gln Leu Asn Leu Leu Lys Arg Lys 
        275                 280                 285             


Leu Thr Leu Lys Glu Leu Leu Phe Asp Leu Phe Leu Gln Pro Glu Asp 
    290                 295                 300                 


Ser Pro Asp Ala Val Phe Gln His Leu Leu Glu Asn Ala Gln Arg Thr 
305                 310                 315                 320 


Leu Ile Ile Phe Asp Gly Leu Asp Glu Phe Val Gly Asn Met Asp Val 
                325                 330                 335     


Ser Ser Ala Ser Lys Gly Ser Leu Asn Arg Ser Ser Ser Met Ser Ile 
            340                 345                 350         


Ser Glu Leu Phe Ala Glu Leu Cys His Gly Asn Leu Leu Pro Gly Cys 
        355                 360                 365             


Thr Val Leu Val Thr Ser Arg Pro Lys Arg Val Pro Asp Phe Leu Ile 
    370                 375                 380                 


Asn Thr Val Asp Leu Leu Ala Glu Val Trp Gly Phe Asp His Glu Lys 
385                 390                 395                 400 


Val Glu Glu Tyr Val Ser His Tyr Phe Arg His His Ser Phe Lys Glu 
                405                 410                 415     


Gln Ala Ile Ala His Leu Lys Asn Asn Thr Lys Leu Leu Ser Met Cys 
            420                 425                 430         


Gln Ile Pro Ala Leu Cys Tyr Val Val Cys Ile Cys Leu Glu Tyr Leu 
        435                 440                 445             


Leu Leu Lys His Gln Thr Ser Val Glu Leu Pro Gln Thr Met Thr Gln 
    450                 455                 460                 


Phe Tyr Ile Lys Met Leu Leu Ile Phe Ile Asn Lys Gln Gln Gly Glu 
465                 470                 475                 480 


His Ala Gly Asp Glu Glu Ala Gln Leu Asn Ser Asn Lys Lys Ala Ile 
                485                 490                 495     


Leu Gly Leu Cys Asp Leu Ala Leu Lys Gly Leu Glu Ala Lys Lys Leu 
            500                 505                 510         


Val Phe Tyr Val Gly Asp Ile Pro Glu His Val Lys Glu Phe Ala Ser 
        515                 520                 525             


Leu His Gly Leu Leu Thr Val Phe Glu Val Lys Thr Asn Ser Ala His 
    530                 535                 540                 


Pro Glu Thr Gly Tyr Ala Phe Val His Leu Ser Leu Gln Glu Phe Phe 
545                 550                 555                 560 


Ala Ala Leu Cys Leu Met Ile Ser Lys Ser Val Asp Lys Ser His Leu 
                565                 570                 575     


Lys Arg Lys Leu Ser Leu Lys Ser Lys Trp Thr Leu Arg Asn Glu Ala 
            580                 585                 590         


Lys Thr Gly Phe Met Glu Ser Phe His Ile Phe Leu Ser Gly Leu Ser 
        595                 600                 605             


Ser Lys Glu Cys Arg Thr Phe Ile Met Leu Leu Ala Glu Gln Ser Glu 
    610                 615                 620                 


Ala Trp Val Gln Asp Lys Gln Asp Ala Ile Leu Gln Ser Leu Lys Lys 
625                 630                 635                 640 


Leu Ala Ala Thr Gln Leu Thr Gly Pro Lys Val Ile Glu Leu Cys His 
                645                 650                 655     


Cys Thr Phe Glu Thr Gln Gly Leu Glu Val Ala Gln His Ile Gly Ser 
            660                 665                 670         


Leu Leu Asn Phe Lys Tyr Glu Phe Lys Asn Phe Arg Leu Thr Pro Leu 
        675                 680                 685             


Asp Met Ser Ala Leu Val Phe Val Ile Asn Ser Gly Gln Asp Val Thr 
    690                 695                 700                 


His Leu Asp Phe Ala Gly Cys Pro Leu Asp Thr Asp Cys Leu Glu Met 
705                 710                 715                 720 


Leu Ala Ser Cys Arg Asn Val Glu His Leu Ser Phe Arg Ser Arg Arg 
                725                 730                 735     


Phe Gly Asp Asp Phe Ala Ala Ala Leu Ser Lys Gly Leu Gly Glu Met 
            740                 745                 750         


Gly Ser Leu Lys Lys Leu Glu Val Thr Gly Gly Ser Ile Thr Ala Ala 
        755                 760                 765             


Gly Leu Thr Asp Met Val Gln Ala Leu Ser His Cys Leu Gln Leu Glu 
    770                 775                 780                 


Glu Ile Asn Leu Gln Asp Asn Arg Ile Gln Asn Pro Asp Val Lys Thr 
785                 790                 795                 800 


Val Met Glu Leu Phe Ser Arg Met Glu Lys Leu Lys Lys Ile Asp Leu 
                805                 810                 815     


Ser Lys Asn Ser Leu Ser Leu Asn Ala Val Leu Leu Leu Ala Lys Glu 
            820                 825                 830         


Phe Ile Ala Cys Gln Asn Ala Ala Glu Leu His Val Arg Lys Asp Thr 
        835                 840                 845             


Val Ile Ile Ser Phe Ser Gly Pro Ser Gly Lys Val Pro Arg Ser Leu 
    850                 855                 860                 


Asp Leu Lys Arg Glu Gln Asn Lys Glu Cys Val Thr Pro Thr Arg His 
865                 870                 875                 880 


Leu Arg Leu Cys Leu Gln Ala Arg Cys Leu Ser Ser Gln His Ala Lys 
                885                 890                 895     


Glu Ile Val Ser Ile Leu Gln Ser Cys Pro His Leu Ser Glu Val Asp 
            900                 905                 910         


Leu Ser Asp Asn Lys Leu Gly Asp Glu Gly Cys Ser Phe Leu Leu Glu 
        915                 920                 925             


Asn Leu Ser Trp Ile Ser Ile Ser Lys Gln Leu Asn Leu Tyr His Asn 
    930                 935                 940                 


Thr Ala Val Leu Arg Phe Thr Glu Asp Gly Glu Phe Ala Ser Pro Pro 
945                 950                 955                 960 


Ala Ser Arg Glu Glu Pro Leu Tyr Pro Thr Asp Asp Gln Trp Asp Asp 
                965                 970                 975     


Lys Glu Asn Gln Thr Pro Val Pro Ser Lys Lys Ile Arg Leu Thr Tyr 
            980                 985                 990         


Cys Arg Phe Gln Ala Ser Asp Leu  Glu Lys Leu Cys Ala  Val Leu Lys 
        995                 1000                 1005             


Glu Cys  Gly Ser Ile Ser Glu  Leu Glu Leu Asn Asn  Asn His Leu 
    1010                 1015                 1020             


Ser Leu  Ser Ser Val Phe Cys  Leu Ala Gln Ser Leu  Cys Thr Leu 
    1025                 1030                 1035             


Glu His  Leu Glu Thr Met Asp  Leu Ser Leu Gly Arg  Met Gln Val 
    1040                 1045                 1050             


Val His  Leu Thr Phe Gly Asp  Arg Ile Arg Leu Arg  Arg Thr Ser 
    1055                 1060                 1065             


Arg Trp  Arg Ser Cys Phe Leu  Val His Pro Lys His  Val Thr Asn 
    1070                 1075                 1080             


Gly Gln  Cys Phe Arg Leu Arg  Asn Cys Thr Val Gly  Pro Glu Asp 
    1085                 1090                 1095             


Val Thr  Arg Leu Cys Gln Met  Leu Met Gln Cys Thr  Gln Leu Thr 
    1100                 1105                 1110             


Glu Ile  Asp Leu Cys Gly Asn  Ala Leu Asn Asp Gln  Ser Ile Glu 
    1115                 1120                 1125             


Arg Leu  Leu Ser Phe Leu Pro  His Phe Cys Gln Leu  Thr Leu Leu 
    1130                 1135                 1140             


Ser Ile  Arg Asn Asn Thr Phe  Ser Pro Cys Cys Ala  Val Leu Phe 
    1145                 1150                 1155             


Ala Asn  Ser Ile Asn Leu Cys  Glu Arg Ile Arg Arg  Val Glu Val 
    1160                 1165                 1170             


Arg Ser  Ser Gln Asn Ala Phe  Leu His Leu Arg Thr  Ser Thr Gln 
    1175                 1180                 1185             


Gly Gln  Lys Thr Ser Cys Arg  Leu Thr Asp Cys Ala  Ile Gly Gln 
    1190                 1195                 1200             


Arg Gln  Ile Glu Lys Leu Cys  Arg Val Leu Glu Gln  His Gly Cys 
    1205                 1210                 1215             


Leu Ala  Glu Leu Asp Leu Ser  Arg Asn Gln Leu Gly  Asp Glu Val 
    1220                 1225                 1230             


Leu Arg  Phe Leu Leu Asp His  Leu His Arg Val Pro  Val Thr Cys 
    1235                 1240                 1245             


Ser Leu  Asn Leu Ser His Asn  Arg Ile Ser Gln Arg  Gly Val Leu 
    1250                 1255                 1260             


His Leu  Ile Asn Thr Phe Thr  Thr Ser Gly Asn Thr  Thr Glu Val 
    1265                 1270                 1275             


Gln Val  Ser Leu Cys Ser Lys  Ala Thr Leu Ile Ile  Lys Met Thr 
    1280                 1285                 1290             


Ser Arg  Asp Asp Pro Arg Lys  Ile Leu Arg Leu Thr  Glu Cys Ser 
    1295                 1300                 1305             


Phe Gln  Pro Glu His Leu Glu  Lys Leu Cys Leu Val  Leu Glu Asn 
    1310                 1315                 1320             


Cys Thr  Asn Leu Thr Glu Cys  Ile Ser Ser Asn Asn  Asn Val Thr 
    1325                 1330                 1335             


Val Asp  Ala Ala Gly Gly Leu  Leu Arg Ser Leu Ser  Lys Thr Pro 
    1340                 1345                 1350             


Gly Pro  Leu Lys Ile Ser Ile  Glu Glu Pro Trp Val  Cys Lys Leu 
    1355                 1360                 1365             


Ser Val  Thr Ser Leu Leu Glu  Leu Ala Val Gln Ala  His Gly Asn 
    1370                 1375                 1380             


Ile Thr  Ala Ile Met Ile Cys  Lys Glu Lys Asn Leu  Phe Gln Leu 
    1385                 1390                 1395             


Gly Val  Arg Leu Pro His Cys  Leu Glu Lys Val Gly  Ser Val Val 
    1400                 1405                 1410             


Ser Arg  Leu Asn Leu Asn Glu  Pro Glu Ile Lys Gln  Ala Cys Phe 
    1415                 1420                 1425             


Tyr Gln  Arg Val His Asp Lys  Cys Thr Gln Leu Gln  Glu Leu Arg 
    1430                 1435                 1440             


Trp Ser  His Val Glu Leu His  Asp Asp Thr Glu Met  Leu Val Ser 
    1445                 1450                 1455             


Ile Leu  Leu Pro Leu Pro Asp  Leu Lys Lys Phe Glu  Leu Thr Ser 
    1460                 1465                 1470             


Cys Ser  Phe Thr Pro Thr Gly  Ile Asp Cys Leu Ile  Thr Gly Leu 
    1475                 1480                 1485             


Gln Arg  Cys Gln Ala Ile Glu  Glu Leu Asn Leu Gly  His Met Lys 
    1490                 1495                 1500             


Leu Gly  Asp Ala Ala Ile Pro  Lys Leu Val Phe Gly  Leu Cys Glu 
    1505                 1510                 1515             


Met Pro  Ser Leu Lys Arg Leu  Ile Leu Asn His Asn  Ser Ile Gly 
    1520                 1525                 1530             


Asp Asp  Gly Cys Ser Arg Leu  Ala Glu Ala Leu Ser  Ser Met His 
    1535                 1540                 1545             


Cys Met  Glu Glu Ile Asn Leu  Gly His Asn Lys Ile  Gly Asp Leu 
    1550                 1555                 1560             


Gly Leu  Ile Asn Ile Ala Ala  Val Leu Leu Glu Met  Gln Asn Leu 
    1565                 1570                 1575             


Lys Arg  Ile Asp Leu Ser Gly  Asn Cys Pro Ser Pro  Ala Gly Gly 
    1580                 1585                 1590             


Glu Lys  Leu Met Glu Ala Leu  Ala Asn Cys Lys His  Leu Glu Glu 
    1595                 1600                 1605             


Leu Ile  Leu Ser Glu Asn Asn  Leu Gly Glu Gly Gly  Ile Arg Ala 
    1610                 1615                 1620             


Leu Ser  Glu Gly Leu Pro Arg  Phe Glu His Leu Arg  Lys Ile Glu 
    1625                 1630                 1635             


Leu Arg  Leu Cys Gly Ile Thr  Asp Asp Ala Ser Lys  Leu Leu Ser 
    1640                 1645                 1650             


Arg Gly  Phe Gln Gln Cys Pro  Ala Val Glu Glu Ile  Ile Leu Ser 
    1655                 1660                 1665             


Trp Asn  Ala Leu Gly Asp Gly  Gly Ala Gln Val Leu  Ala Ser Ile 
    1670                 1675                 1680             


Leu Pro  Gly Met Glu Thr Leu  Lys Met Leu Asp Leu  Glu Lys Asn 
    1685                 1690                 1695             


Leu Ile  Gly Ala Cys Gly Ala  Thr Arg Leu Ala Glu  Glu Leu Val 
    1700                 1705                 1710             


Arg Cys  Pro Glu Ile Gln Phe  Ile Arg Leu Trp Asp  Asn Pro Val 
    1715                 1720                 1725             


Pro Lys  Gly Leu Ala Glu Ser  Leu Thr Ser Gln Asp  Pro Arg Leu 
    1730                 1735                 1740             


Cys Phe  Ser Phe Cys 
    1745             


<210>  7
<211>  5235
<212>  DNA
<213>  Dog

<400>  7
atggctttta ccttcctgaa ggtgctcaac aacatggaga ttgacacttc tctgtttgat       60

gaagtgggag ccaagatcat caaagacctg atgtccaaag ctgagaagaa tggtgtgaaa      120

attatcttgc cagttgactt tgtcactgct gaaaagtttg atgagcatgc caggactggc      180

caagccactg tggcctctgg catacctgct ggctggatgg gcttggactg tggtcctgag      240

agcagcaaga agtatgctga ggcagttgct tgggctaagc agatcatgtg gaatggacct      300

gtgggcgtat ctgaatggga agctcttgcc cgaggaacca aagccctcat ggatgaggtg      360

gtgaaagcca ctgcctggga ctgcatcacc atcataggtg gtggagacat tgccatttgc      420

tgtgtcaaat ggaatacaga ggataaagtc agccatggcc agctcctcat ggaccacgtt      480

agcttccagc tgggtaccac taacctgtgg agctggctcg tgaggctgct cagtaaagac      540

ccagaatggc tgaatgccaa ggtgaagttc ttcctcccca agatggacct gagctccggg      600

gacgaggccc aggacaccac acagagggtc atgctacagc tcagaagatt gcacacccaa      660

ggtcgggcca cttggcaggc attcatccac tgtgtgtgca tggagctcga tgtgcccctg      720

gacctggagg tgccactgct gagcacttgg ggccatggag atggtctgaa gcggcctcat      780

cagagctgtg ggtcctcacc ccgcctgaag cagtgcaaga atcatcagct cgagttggcc      840

aggaggtacc tgaagttgct gaggacttct gcccagcagc gctacagcag gattcccggg      900

ccggggcaac cccttgcctt ccaccaggcc tacatccccc caatcctgca gtggagccgg      960

accacggccc ccttcagtgc tcaggacggg gctgtagtgg gggaccccaa ggcagaagat     1020

gacacggacg tgagcatccg ggacctcttc agcaccaggg ccgacaaggg cccgagggtg     1080

acggtgctcc tggggaaggc aggcatgggc aagaccacgc tggcccaccg gctctgccag     1140

aggtgggctg ctggccagct tgaccgcttc caggctctgt tcctgtttga attccgtcag     1200

ctcaatctga tcaccagttc cgtgacgctg ccccagctgc tgtttgacct gtacctgagc     1260

cccgaggcgg gccccgactc ggtcttccag tacctggagg agcatgctgg aggagtcctg     1320

ctgatctttg atgggctgga ccaggccctc cactcgcatt ccagcacgga gcctgaaggc     1380

cccgaggccc caagtccggc ccttgccctc ttctccgggc tctgccgggg gaccatcctg     1440

cctggctgct gggttttggc cacctcccgt ccagggaagc tgcccgactg cctgcccaca     1500

gaggcagcca cggtccacat gtggggcttt gacaggccac gggtggagga gtatgtgggc     1560

cgcttcttca gtgaccaaga gtggcaggaa gcagccctag cagagctgcg agaaaacagg     1620

catctccaga gcatgtgtgc ggtgcctgca ctgtgccaag tcacctgcct ctgcctccac     1680

catctgctcc caggcaactc tccaggccag tctgcagccc tcctgcccac cgtgactcag     1740

aactatgtac agatggtgtc cactctcagc ccccgtgggt acctgcctcc cgagtctctg     1800

ctgggcctca gtgagatggc tctgaggggc ctggagactg ggaaggttat cttctctgta     1860

ggcgacatct ctccacccat ggtggctttt ggggcagccc tcggcttgtt gacctccttc     1920

tgcatctgca caggccctgg gcaccagggt ataggctatg ccttcaccca cctcagccta     1980

caagagtttt ttgccgcctt gtacctgatg gccagcccca aggtggacaa aaatgtactt     2040

gcccgccatg tcaccctcaa ttctcgctgg gtgctacgga ccaaagctag actaggcctc     2100

ttagaccacc tccccacctt cctggcaggg ctggcatcct gtgcctgccg acccttcctt     2160

agccatgtgg cccagcagga tgagatgtgg gtgagtgaca agcaggctgc agtgatgctg     2220

gctttgagga agttggccat tcgcaggctc acaggaccca aggttgtagc actctgtcac     2280

tgtgtgggtg agacccagga gcctgagctg gccagcctca tggcccaaag tctccccagt     2340

cacctgtcct tccacaattt cccactgacc tatacggacc tgtctgccct gaccaacatc     2400

ttgaggcaca ggaatgcctc catccacctg gattttgagg gctgccccct ggagccccac     2460

tgccccgagg ccctggcagg ctgtaagcag atagagaatc tcagctttaa gagcaggaaa     2520

tgtggggatg cctttgcaga agccctctcc aagagcctgc caacaatgga gagcctgaag     2580

aagctcgggt tagcaggatg taagatcact gcccgaggca tcagccacct gatgcaggct     2640

ttgcgcctct gtccacagct ggaagagatc agcttccagg acaaccagct gaaggatagg     2700

gccgtgctga atatcgtgga agtacttcct tctttgccac ggctccagaa gcttgacctg     2760

agccgcagca atgtctccgt gtcaacctta ctctgcttga caaaggtggc ggtcacatgc     2820

cctactgtca agatgctaca ggtcaggctc ctgcagtgcc agctcggaat tcatgatgtg     2880

caggagctca ttgcccagct ccgggaaggt ccccgcctgg aggaagtaaa cctcagcaac     2940

aacgggctat ctgtggacag ggtacactgt atgctgagtg cggtgaacac atgccagaac     3000

ttggcagagc ttcatatcag cctgctgcat aaaactgtgg tcttcacatt tgccccagag     3060

caggaggagc aggaggggat ctggaagagg actgcgcttc gggacagcct cacgcaccag     3120

gtgccctttg agctgcccct gcgctccacg aggatcagcc tctcaggcaa tgctctgggg     3180

gatgaaggcg tggcccagct ggctcagctg ctcccagggc tgggtgctct gcagtccttg     3240

aacttcgaga gccagcacgt cgtcctgaga ggtgacagaa gaggcagcct caggcaatgt     3300

cagctggagc ccctgaacct cacccgcctc tgcgagactc tggagaagtg ccccgggcct     3360

ctggaagtcg aattgtcctt tgaggtcctg agcgaccaga gcctggagac cctgctgcag     3420

cacttacccc ggctgcccca gctaagcctg ctgcagctaa gccagacgag gctttcccca     3480

aagagcctcc tcctgctggc cgacctcttc agcttatgcc cccgggttca gaaggtggat     3540

atcaggtccc tgtatcacat gacactgcac ttcaggtctg gcgaggagca tgaaggcgag     3600

tgctgtgggt tcacgggctg tggccttagt caggagcatg tggagccgct ctgctggttg     3660

ctgagcaaat gcgaagacct caaccagttg gacctgagtc acaacagcat ctccctagag     3720

agtgccctgg gcctggtgaa gacactcccc tcctgcccgc acatccggga ggcttctgtg     3780

aaggctcggg aagctgggcc tccgacctcc ccacaccctt gtctctgcag cctgggctct     3840

gagcagagct tctggatcta cttctcccga aaggaggagg ccgggaagac actaaggctg     3900

agccagtgca acctcatgcc agagcatgtg cccagactgg ccacccacct gaaccaggcc     3960

ctgaagctga cagcgctcac gctgacccag tgcggcctgg gcctggagca gctgatagtt     4020

ctcctgagtc tgctgagatg tccagtggac ctgttcactc tcagggtgga ggagccgtgg     4080

gtaggcaaag ccggggtgct cgccctgcta agagtctgca cccagacctc aggcaacatc     4140

actgaaataa gcatttcgga gacccagcag cagctctgtc tccagctgga gtttccccct     4200

caggagaacc cagaagccgt gacgctcagg ttggctcact gtgaccttga gacccaccac     4260

agccttcttg ctgggcagct gatggagaca tgtgccaggc tgcagcagct cagcttgtcc     4320

caggtgaacc tctgcgactc cagctccctg ctgctaaaaa acctcctggt gtctctctct     4380

gagctgaaga cattcagact gacctccagc tgtatgagct ccaagggcct ggcccacctg     4440

acatttggcc tgagaaactg ccaccacctg gaggagctgg acttgtccaa caatcagttt     4500

ggtgaggagg acactgaagt cctgatgacg gtccttgagg gcaagtgctg gctgaagaag     4560

ctcgacctca gccatctccc actaggcagc tccaccctgg ccatgttcac tcaaggacta     4620

agccacatga ccctcctaca gagcctccgg ctgagcagga acggtatttg tgatgtcggc     4680

tgccaccaac tttccgaggc cctcagagct gccatgagct tgaaggagct ggggcttggc     4740

tacaacgtcc tgggggatac cacagccctg ggcctggccc agggactgcc ctgctgcctg     4800

agggtcctgc acctgccgtc tagccgtctg ggcccaaagg gagcgctgag cctgagccag     4860

gccctggatg gatgcccaca tgtggaagag atcagcctgg tttcgtgtga gatcgacaac     4920

cacaccgcca agcccctggc tgccagcctg gtgctctgcc cagccctgga agaaatcctg     4980

ctgtcctgga atctgctcgg ggacgaggcg gctgccgagt tggcccgggt cctgccgcag     5040

atgggccggc tgaagagaat ggacctggag aagaatcgga tcacagcttg tggagcctgg     5100

ctcctggctg aagggctggc acaagggtct ggcatccaag tcattcgcct ctggaacaat     5160

cccatctccc ccaccatggt ccagcatcta cagagccagg agcccaggct ggacttcgct     5220

ttcttcgaca aatag                                                      5235


<210>  8
<211>  5932
<212>  DNA
<213>  Bull

<400>  8
atggaccccg ttagcctcca actgggcacc aagaacctgc atggatatct cgtgaggctg       60

ctcagcagaa acctaggatg gctagacgcc aaggtgaagt tattcctccc cagcgtggac      120

ctgggctccg gatatcaggc cctagacccc acacagaggg tcatcctgca actccaaaaa      180

ctgcatgccc agggtccgac cacctggaag tcattcatcc agtgcgtgtg catggagctg      240

gatgtgccaa tggacatgga ggtgctgctg atgagcacgt ggggccacga agatggcttc      300

tccagtcttc tggaaattga cgaggaaagc caatcagact ctcagctcca ccctggcctc      360

aagcggactc atcagagctg tgggtcctca cctcgcccaa aacagttcag gaagcagcaa      420

caagagttgg ccaagaggta cctgcagcta ctgagaactt ctgcccagca gcgctatggc      480

aacaggaccc ccgggccggg acagccattg gccttccacc aagcctacgt ccctccaatc      540

ttgaaatgga gccgggcctc ggcgcccttc cacactcagg agggtgccac aacagggaac      600

cccaaggcag aagacggcac tgatgtgaac gttcgggacc tcttcagtac caaggccagc      660

aagggcccga gagtgacggt gcttctgggg aaggcgggca tgggcaagac cacgctggct      720

caccggctct gccagaagtg ggccgatggt cagctggacc gcttccaggc tgtgttcctt      780

ttcgaattcc gccagctcaa cctgatcaca ggttccttga cactgccgca gctccttttc      840

gacatgtacc taaggcctga ggccagcccg gaggccgtct tccagcacct gaaggagaac      900

gcggagggaa tcctgctgat cttcgacggg ctggacgaga tcctccagcc ctgctctgac      960

aaggagaccg aggaccccga ggacccagcg tcagccctca ccctcttctc ccgcctctgc     1020

cgtgggaccc tgctgcccgg ctgctcggtg atggccacct cccgtccagg gaagctgccc     1080

gcctgcctgc ccaccgaggc ggccacggtc cacatgtggg gcttcgacgg cccgcgggtg     1140

gaggagtatg tgaaccactt cttcagcgac cagccgtccc aggaggcggc cctggcggag     1200

ctgcagatgg acagacacct ctggagcatg tgtgcagtgc ctgcgctgtg ccgagtcgcc     1260

tgcctctgcc tccatcacct gctcccgggc aggtctcgag gccagtctgc agccctcctg     1320

cccaccatga cgcagaacta catgcagatg ctcctcaccc tcaaccccca aggggtcctg     1380

cgggctgagc ccctgctggg tctcggggag gtggccctga gcggcctgga gtcagggaag     1440

gtcatcttct ctgcaggaga catccctgca tccaccctag actttggggc tgccctcggt     1500

ctgctgacct ccttctgcgt gtgcctgggg cccgggcacc gggacacagg ctacgccttc     1560

tcccacctca gcctgcagga gttcttcgca gccctgcacc tgctggccag cccccaggtg     1620

gacagagagg ccctcagcca acatgtcacc ctccattctc gctgggtgca gcggacaaaa     1680

gccagactgg gcctgtcgga ccacctgccc acctttctgg ctggcctggc atcccgtgcc     1740

tgccgctcct tcctcagcct cctggctgag cgggaggagg aatgggtggc tgccaagcag     1800

gaggtagtcc tgcaggcgct gaagaagttg gccacccgtc ggctcacggg gcccaaggtt     1860

gtagagctgt gtcaccgtgt gggtgagacg caggatcctg agttggccag cttcatggcc     1920

cgcagcctcc cccagcagct gcccttccac aacttcctgc tgacctacgc cgacctggcc     1980

tccctgacca gcatcctggg gcacagggat ggccccatcc acctggattt tgagggctgc     2040

cccctggagc cccgctgccc tgaaaccctg gcaggctgtg ggcaggtaga gaatctcagc     2100

tttaagagtc ggaagtgtgg ggacgccttt gcagaagccc tctccaagag cttgccaacg     2160

atggggagcc tgaagaagct ggggttagca ggaagtaaga tcactgctca aggcatcagc     2220

cacctggtgc aggctttgcc cttctgccca cagctggagg aggtcagctt ccaggacaat     2280

cagctcaagg acagggaagt gctgaacatc gtggaggtac tctcttgcct accacggctc     2340

cagaaacttg acctgagccg caacaatgtc tccgtgtcaa cactactctc cttgacaaag     2400

gtggcggtca cgtgccctac catcaggatg ctgcaggtca gggagacgga cctcatcttc     2460

ctcctctccc cgcccacaga gacagatcct gagctacaag gagacccaga cttacaggga     2520

aatgccaacc agaggaaaga ggctcagaga agaagcctgg cactcaggct ccagaagtgt     2580

cagcttgggg tccatgatgt ggaggtgctc atagcccagc tgcgggaagg ccctcaactg     2640

gatgaagtgg acctctcagg gaaccagctc aaagataaag gctgtcaact gatggcagag     2700

gctgctcccc aactgcacat cacgaagaag ctggacctca gcgacaatga gctttctgtg     2760

gccggggtgc tgggagtact gagtgtggtg aacacgtacc aaaccctgac agagctacat     2820

atcagcctgc tgcacaaaac tgtggtcttc acgtttgccc cagagctgga ggagcaggag     2880

gggatccaga agagggctac gtttcctgac agccttatgt tccagatgtc ctctgagcca     2940

tctctgcgct ccccgaggat caggctgacg cactgtgccc tgcaagccca gcgcctggag     3000

ctgctctgca aagcgctggg aggaagttgc cgcctcagtc accttgactt atcaggcaat     3060

gctctggggg atgaaggtgt ggccctgctg gctcggctgc tccccggact gggttctctg     3120

cagtccttga acctcagtga gaaccatttg tccctggagg gtgtgtgcag tttgacccag     3180

tgcttctcta ctctgcggtg gcttctacat ttggaattca gctctgcaag ccaacacgtc     3240

atcctgagag gcgacaaaag aggcagggat ctgttggctg ctggatcttt gccagagttc     3300

cgagctggag cccggttggg atctggtcag cgccacgtcc ccaggagctt ctgcctcaag     3360

gaatgtcagc tggagcccct gagcctctcc tacctctgca agtctctgga gaagtgccca     3420

gggcccctgg aagtccaatt gtcctgcgag gtgctgagtg accagagcct ggagaccctg     3480

ctgtaccacc taccgcagct cccccagcta agcctgctgc aactgagcca gatgcaactg     3540

cctccagaga gccccctcct gctagctgac ctcttcagcc tgtgcccaca ggttcagaag     3600

gtggatctca ggtccctgcg tcatttgacc ctgcatctca ggtctagtga ggagcaggaa     3660

gacaggtgct gttggaggtt cactgactgc ggcctccgcc aggagcacgt ggagccgctg     3720

tgcgggttgc tgagcaagtg tgaagacctc caccagctgg acctctcagc aaacctgctg     3780

ggtgatgatg ggctcaggtg cctcctggaa tgtctcccca aggtgcccat ttccggttcg     3840

cttgatctaa gccacaacag tatgtctcag gaaagcgtct tgtgcctggt ggaggcgctc     3900

ccctcctgcc cacgtctccg ggaggcctca gtgaacctgg gctccaagca gagcttctgg     3960

attcacttct cccgacagga agagactggg aagacactga ggctgagcga gtgccacttc     4020

aagccagagc acatgcccag actggccgcc agcctgagcc aggccctgca gctgacggag     4080

ctcacgctga cctggtgttt cccgggcctg gagcagctga ctgtcctcct gggtctgcta     4140

acgtggccga cgggggtgct cactctcagg gtggaagagc catgggtggg cagagtcggg     4200

gtgctcacgc tgctggaagt ctgtgcccag gcctcaggca acatcactgg aataagcatc     4260

tccgagaccc agaaacagct ctgtatccag ctggaatttc cccatcagga gaacccagaa     4320

gccgtggccc tcaggctggc tcactgtgac ctgggaaccc aacaaaacct cctcgccagg     4380

aagttgatgg agacatgtgc ccggctgcgg cagctcagtt tgtcccaggt gaacctctgc     4440

gatgccagct ctctgctgct gcaaagcctc ctgctgtccc tctctgagct gaagaacttc     4500

aggctgacct ccagctgtgt gagctccaag gggctagccc tcctgacatc tggtctgagc     4560

cattgtcacc ttctggagga gctagacttg tctaacaatc aacttggaga cgagggcacc     4620

aaggtgttgt tgggggctct tgagggcaag tgcaggctga agagacttga cctcagccac     4680

ctgccactgg gcggctccac cctggctgtg ctcactcaag gactaggcca catgacactc     4740

ctgcagagcc tccgtctgag caagagcaac atcgatgacg tcggctgctg ccacctttcg     4800

aaggctctca gagctgccac cagcttggag gagctgagct tgagccacaa ccagatcgga     4860

aacatcggtg cccaggactt agctgctgtc ctgccggggc tccctgagct caggaagata     4920

gacctctcag caaatggcat cggcccagca ggcggagcgc ggttggcaga atctctcacc     4980

ctttgcaggc acctcgagga gctgatgctt ggctgcaatg ccctgggaga ctgcacagcc     5040

ctgggtctgg ccaaggggct gccccagcac ctgagggtcc tgcacctgcc atccagccat     5100

ctgagcccag agggggtgct gagtctgggc caggccctgg atggatgccc acacgtggaa     5160

gagatcagct tggcagagaa cagcctggct ggaggggtcc cgcatttcca tcaggggttc     5220

ccagtgctcc ggaagcttga cctggtgtcg tgtgagattg acaaccagac cgccaagccc     5280

ctcgccgcca gcttcgtgct ctgtctggcc ctggaagaaa tcacgctgtc ctggaatctg     5340

ctcggggatg aggcagctgc tgagctggcc cgggtcctgc cgcagatggg ccggctgaag     5400

agaatggacc tggagaaaaa tcagatcaca gcttatggag cctggctcct ggctgaaggg     5460

ctggcacagg gatctggcat ccaagtcatt cgcctctgga ataaccgtat tcccccggac     5520

atggcccagc atctgcagaa ccaggagccc aggctggact ttgctttctt tgacaaccag     5580

ccacaggtca tccctcgggg tacctgatgg tgccctcaag tccctttgaa tccagccgag     5640

tgatgccagt tttcatccat gaggatagag ggctcatgaa aaaagctggc tgtccctgga     5700

tcaagaggga gaaacacact tttcctgcaa cagtcttcag ggaggacatt tttggtgaca     5760

aagagcggag tatgactacc ctacatccct tgggacatgc atgaccagtc aggaacatga     5820

agcaaaatga gcgtgtcatg gtgtggtgtg tgatgtggaa ggtcacacgt ggcgacattc     5880

catgtgacct tgcacgatac ctgaaacgtg gcctgggggt cgatggcatg cg             5932


<210>  9
<211>  5693
<212>  DNA
<213>  Horse

<400>  9
cagtttcagg tggcgcgcgg cggcgcgggg accgcggctg gggcctcccc actggaaaca       60

acctgcaaat ccagctcagg ccgtggggct tggccgaggc acccatgaga ccctctccgc      120

agacgcgcta gaacacctat gatgaaccag gaggccaagg caagctcctc atggaccccg      180

atagcctcca gctgggcacc aagagcctgt ggagctggct cgtgaggctg ctcagccaag      240

ccccagaatg gatgaacgcc aaggtgaagt tcttcctccc caacatggac ctgggctcca      300

ggagcgaggc cctggacccc tcgcagagga tcatccaaca gctcagggaa ctgtacgccc      360

agggcccggc cccctggcag acgttcatcc actgcgtgtg catggagctg gaggtgccgc      420

tcgagctgga ggtgccgctg ctgagcacgt ggggccacgg agacgggttt cccagtccgc      480

tggaagctgg tgaggactgc ggaccagaat ctcagctcca gcacggtatc aagcggcctc      540

atcagagctg tgggtcctcg ccccgcccaa agcagtccag gaagcagcag ctagagttgg      600

ccaagaggta cctgaagctg ctgaggagtt ctgcccagca gcgctacggc ggcaggatcc      660

tggggccggg gcagccgctt gtcttccccc aggcctacgt ccccccagtc ctgcagtgga      720

gccgagccac ggcgcccttc agcactcagg agggggccct tatgggggac cccaaggcag      780

aagatggcac cgacgtgagc atcctggacc tcctcaacac cagggctgac aagggtccca      840

gggtgagggt gcttctgggg aaggcgggca tgggcaagac cacactagcc cactggctct      900

gccagaagtg ggccgacggc cagctggacc gcttccaggc cctgttcctt tttgaattcc      960

gccagctcaa cctgatcaca agtgtcctga cactgcctca gctccttttt gatctgtacc     1020

tgagccccga ggagggccct gacgccgtct ttgagtacct ggaggacaat gctaatgggg     1080

tcctgctgat ctttgatggg ctggacgagg ccctccagcc ctgttccagc ggagagactg     1140

tagatcctga ggccctaggt ccagccctca ccctcttctc tgacctctgc cgtgggaccc     1200

tcctgcccgg ctgctgggta atggccacct cacgtccagg gaagctgccc gcctgcgtgc     1260

ccacggaggc ggccacggtc cacatgtggg gttttgacag gccacgggtg gaggagttcg     1320

tgggccgctt cttcagcgac ctgccgtcgc agaaggccgc cctggcagag ttacgggcaa     1380

acagacgtct ccggagcttg tgtgcggtgc ctgcactgtg ccgtgtcacc tgcgtctgcc     1440

tccaccatct gctcccaggc agctccccag gccagtctgc ggccctcctc cccaccatga     1500

ctcagaccta tgtgcagatg atgctcgccc tcaggccccg tgggtacctg cctgccaatt     1560

ccctgatggg tctctgtgag gtggccctga gtggcctgga gaccgggaag gttatcttct     1620

ctgccagaga catccctcca gccacgttgg cctttggggc tgcccacggc ctgctgatct     1680

ccttctgcat ctgcatcagc cctgggcgcc aggagacagg ctatgctttc ccctacctca     1740

gcctgcagga gttttttgct gccctgcacc tgatggccag ccccgaggtg gaccaagatg     1800

cactcgcccg ccatgtcacc ctgaattctc gctgggtgct gcggaccaaa gctcgactgg     1860

gcctctcaga ccaccttccc gccttcctgt cgggcctggc atcctgtgcc tgccgccact     1920

tcctcagcca gctggcacag agagacgagg tgtgggtgag tgccaagcag gctgcggtcg     1980

cgcaggcatt gaggaagttg gccacccgca ggctcacggg gccgaaggtg gtagagctgt     2040

gtcactgtgt gagcgagaca caggagtctg agctggccgg cctggtggcc cagagtctcc     2100

cctatcaact gcagttccac aacttcccac tgacccacgc cgacctggct gctgtgacca     2160

acatcctggg gcacagggat gctcctgtcc acttgaattt tgagggctgc cccctggagc     2220

cctcctgccc tgaggctctg gcaagctgtg ggcaggtaga gagtctcagc tttaagagca     2280

ggaagtgtgg ggatgccttt gcagaagccc tctccaggag cctgccaaca atggggagcc     2340

tgaagaagct ggggttagcg ggaagtaaga tcactgcccg aggcatcagc cacgtggtgc     2400

aggctttgtc cctctgtcca cagctggaag aggtcagctt tcaggacaac cagctcaagg     2460

accaggaggt gctgagcatc gtgaagatac tccctcgcct gccgcacctc cggaagcttg     2520

acctgagccg caaccatgtc tctgactgga ccctactcca cttgacagag gtggcagtca     2580

cgtgccctac cgtcaggatg ctacaggtca cgaaggcgga cctcatcttc cttctctccc     2640

cacctgcaga gacagctgca gagctaccag gagccccaga cctacaggaa agtgccagct     2700

caaggaaaga ggctcagagc agaagcctga cactcaggct acaggagtgt cagctcgggg     2760

tccatgaggt ggagatgctc ttagcccagc tccggaaagg cccccacctg gacgaagtgg     2820

acctttcagg gaaccagctg gaagatgaag gctgcagact gatggcagag gccgcgcccc     2880

agctccacat caccaggaag ctggacctca gcgacaatgg gctctctatg gccgggctgt     2940

accgcgtgct gggtgcagcg agcacgtgcc ggaccctggc agagctgcac atcagcctgc     3000

tgcacaaaac cgtggtcctc acctttgccc cagagccaga ggagcaggcg gggatgcaga     3060

ggagggctgt gtttcctgac agccacgtgc cccagacgcc ctctgagctg cccctgcgct     3120

cccaaaggat caggctggcg cactgtggct tacaagccaa gcacctcgag ctgctctgca     3180

aggcgctgga aggaagccac cacctgggcc acctcgactt atcaagcaat gctctggggg     3240

acgaaggtgc agcccagctg gctcagctgc tcccagggct gggccctctg cagtccttga     3300

acctcagtga gaacggctta tccccggacg ctgggttcag cttggccctg tgcttctcta     3360

ctgtgcagtg ggttctccac ctggacatca cgggtgagag ccaacgcatc gtcctgggag     3420

gagccggaag aggcagggac ctgtcggctg ccggatctgt gccggagttg ccagctggag     3480

ccgagttctt gggctccggt cagcgctgcg tccccaggag cttctgcctc agtgagtgtc     3540

agctggagcc cctgagcctc acccgcctct gtgacactct agagaagtgc ccggggcctc     3600

tggaagtcac attgtcctgc aagggcctga gcgaccagag cctggagacc ctgctgcacc     3660

gcttgccccg gctgccccag ctcagccggc ttcggctgag ccagacagca ctgtccccaa     3720

ggagccccct catactggca gacgtcttca gcctatgccc acgggttcag aaggtggatc     3780

tccagtccct gtgtcacacg accctgcact tcaggtctag cgaggagcag gagggcggat     3840

gctgtggcct ctcagcaaac cagctgggtg atgccgggct ccagtgcctc ctggagcatc     3900

tgcctcgggt gcccatctcc ggttcgcttg atctcagtca caacagactc tctcaggaaa     3960

gtgccctgtg cctggtggag acgctcccct cctgcccacg catccgggag gcctcggtga     4020

acctggggct ccgagcagag cttctgggat tcacttctcc ccaccggagg aggctggaga     4080

agaccctgag gctgaccgag tgtcacttca ggccagagca cgtgccccga ctggcctccg     4140

gcctgagcca ggccccacag ctggcggagc tcacgctgac ccagtgctgc ctgggcctgg     4200

agcagctgac cgtcctcctg agcttggtga ggtggccgag ggggctgctc agtctcaggg     4260

tggaggagcc gtgggtgggc agagccgggg tgctcacgct gccagaagtc tgcgcccagg     4320

cctcaggcaa cgtcactaaa ataagcatct ccgagaccca gcagcagctc tgtgtccagc     4380

tggaatttcc ccgccaggaa aacccaggag ctgtgcctct caggttggct cactgtgacc     4440

ttgggaccca ccgcagcctc cttgtcaggc agctgatgga gacctgtgcc aggctgcggc     4500

agctcagctt gtcccaggtg aacctctgcg acgccagctc cctgttgctg gagaacctgc     4560

tgctgtccgt gtctgagctg aagacattcc ggctgatctc cagccgtgtg agttccgagg     4620

gcctggccca cctgacatct ggtctgagcc attgtcccca cctggaggag ctggaattgt     4680

ccaacactca gtttggcgag gaggacacca aggtgctgat gggggccctt gagggcaagc     4740

gccggctgaa gaggctcaac ctcagccacc tcccgctggg cggctccagc ctggcggtgc     4800

tcactcaagg actcagccga atgatccttc tgcagagcct ccgtctgagc agtaacggca     4860

tcagtgacat cggctgctgc cacctctcca aggccctcag agctgtgacc agcttggagg     4920

agctgggctt gagccacaac cagattggag acactggtgc ccagcactta gctgccgtcc     4980

tgccggggct gcctgagctc aggaaaatag acctctcagc aaatggcatc ggcccggctg     5040

ggggaatgcg gttggtggag tcgctcgccc tttgcacaca cctggaggag ctgatgctcg     5100

gctgcaatgc cctgggggat cccacggccc tgaggctggc ccaggcgctg cccccgcacc     5160

tgagggtcct gcacctgccc tccagccgtc tgggccccga gggggcactg agcctggccc     5220

gggccctgga cagatgcccg caggtggaag tgatcagctt ggcagagaac agcctggccg     5280

gaggggtccc gcacttctgc caggggctcc cactgctcag gcagatagac ctggtttcct     5340

gtgagattga tgaccagacg gccaagccgc tggctgccgg cttcatgctc tgcccggccc     5400

tggaagaaat cttgctgtcc tggaatctgc tcggggatga ggcggctgct gagctggccc     5460

gtgtcctgcc gcggatgggc cggctgaaga gagtggactt ggagaagaat cggatcacag     5520

cttgtggagc ctggctcctg gctgaagggc tggcgcaggg gtccggcatc caagtcatcc     5580

gcctctggaa taacctcatc cccactgaca tggcccagcg tctgcagagc caggagccca     5640

ggctggactt tgctttcttc cacaaccagc caccagctcc tcggggtact tga            5693


<210>  10
<211>  6822
<212>  DNA
<213>  Human

<400>  10
gcagcagccg ccagttccat gcactggcgg agcagctcta ggcggcggct tctactttca       60

gtttcgtgca gagcgcggag gagccgcgag cgctgaggga gtctgcacta tggaaacaac      120

ctgtcaatcc agctcaaggc acacatagcc cagacaccca tgagaccctc tccgtgggga      180

ccctagagca cctatcatga acgaggagac caaggctggc tcctcatgga ccccgttggc      240

ctccagctcg gcaacaagaa cctgtggagc tgtcttgtga ggctgctcac caaagaccca      300

gaatggctga acgccaagat gaagttcttc ctccccaaca cggacctgga ttccaggaac      360

gagaccttgg accctgaaca gagagtcatc ctgcaactca acaagctgca tgtccagggt      420

tcggacacct ggcagtcttt cattcattgt gtgtgcatgc agctggaggt gcctctggac      480

ctggaggtgc tgctgctgag tacttttggc tatgatgatg ggttcaccag ccagctggga      540

gctgagggga aaagccaacc tgaatctcag ctccaccatg gcctgaagcg cccacatcag      600

agctgtgggt cctcaccccg ccggaagcag tgcaagaagc agcagctaga gttggccaag      660

aagtacctgc agctcctgcg gacctctgcc cagcagcgct acaggagcca aatccctggg      720

tcagggcagc cccacgcctt ccaccaggtc tatgtccctc caatcctgcg ccgggccaca      780

gcatccttag acactccgga gggggccatt atgggggacg tcaaggtgga agatggtgct      840

gacgtgagca tctcggacct cttcaacacc agggttaaca agggcccgag ggtgaccgtg      900

cttttgggga aggctggcat gggcaagacc acgctggccc accggctctg ccagaagtgg      960

gcagagggcc atctgaactg tttccaggcc ctgttccttt ttgaattccg ccagctcaac     1020

ttgatcacga ggttcctgac accgtccgag ctcctttttg atctgtacct gagccctgaa     1080

tcggaccacg acactgtctt ccagtacctg gagaagaacg ctgaccaagt cctgctgatc     1140

tttgatgggc tagatgaggc cctccagcct atgggtcctg atggcccagg cccagtcctc     1200

acccttttct cccatctctg caatgggacc ctcctgcctg gctgccgggt gatggctacc     1260

tcccgtccag ggaagctgcc tgcctgcctg cctgcagagg cagccatggt ccacatgttg     1320

ggctttgatg ggccacgggt ggaagaatat gtgaatcact tcttcagcgc ccagccatcg     1380

cgggaggggg ccctggtgga gttacagaca aatggacgtc tccgaagcct gtgtgcggtg     1440

cccgcactgt gccaagtcgc ctgtctctgc ctccaccatc tgcttcctga ccacgcccca     1500

ggccagtctg tggccctcct gcccaacatg actcagctct atatgcagat ggtgctcgcc     1560

ctcagccccc ctgggcactt gcccacctcg tccctactgg acctggggga ggtggccctg     1620

aggggcctgg agacagggaa ggttatcttc tatgcaaaag atattgctcc acccttgata     1680

gcttttgggg ccactcacag cctgctgact tccttctgcg tctgcacagg ccctgggcac     1740

cagcagacag gctatgcttt cacccacctc agcctgcagg agtttcttgc tgccctgcac     1800

ctgatggcca gccccaaggt gaacaaagac acacttaccc agtatgttac cctccattcc     1860

cgctgggtac agcggaccaa agctagactg ggcctctcag accacctccc caccttcctg     1920

gcgggcctgg catcctgcac ctgccgcccc ttccttagcc acctggcgca gggcaatgag     1980

gactgtgtgg gtgccaagca ggctgctgta gtgcaggtgt tgaagaagtt ggccacccgc     2040

aagctcacag ggccaaaggt tgtagagctg tgtcactgtg tggatgagac acaggagcct     2100

gagctggcca gtctcaccgc acaaagcctc ccctatcaac tgcccttcca caatttccca     2160

ctgacctgca ccgacctggc caccctgacc aacatcctag agcacaggga ggcccccatc     2220

cacctggatt ttgatggctg tcccctggag ccccactgcc ctgaggctct ggtaggctgt     2280

gggcagatag agaatctcag ctttaagagc aggaagtgtg gggatgcctt tgcagaagcc     2340

ctctccagga gcttgccgac aatggggagg ctgcagatgc tggggttagc aggaagtaaa     2400

atcactgccc gaggcatcag ccacctggtg aaagctttgc ctctctgtcc acagctgaaa     2460

gaagtcagtt ttcgggacaa ccagctcagt gaccaggtgg tgctgaacat tgtggaggtt     2520

ctccctcacc taccacggct ccggaagctt gacctgagca gcaacagcat ctgcgtgtca     2580

accctactct gcttggcaag ggtggcagtc acgtgtccta ccgtcaggat gcttcaggcc     2640

agggaggcgg acctcatctt ccttctttcc ccgcccacag agacaactgc agagctacaa     2700

agagctccag acctgcagga aagtgacggc cagaggaaag gggctcagag cagaagcttg     2760

acgctcaggc tgcagaagtg tcagctccag gtccacgatg cggaggccct catagccctg     2820

ctccaggaag gccctcacct ggaggaagtg gacctctcag ggaaccagct ggaagatgaa     2880

ggctgtcggc tgatggcaga ggctgcatcc cagctgcaca tcgccaggaa gctggacctc     2940

agtgacaacg ggctttctgt ggccggggtg cattgtgtgc tgagggccgt gagtgcgtgc     3000

tggaccctgg cagagctgca catcagcctg cagcacaaaa ctgtgatctt catgtttgcc     3060

caggagccag aggagcagaa ggggccccag gagagggctg catttcttga cagcctcatg     3120

ctccagatgc cctctgagct gcctctgagc tcccgaagga tgaggctgac acattgtggc     3180

ctccaagaaa agcacctaga gcagctctgc aaggctctgg gaggaagctg ccacctcggt     3240

cacctccacc tcgacttctc aggcaatgct ctgggggatg aaggtgcagc ccggctggct     3300

cagctgctcc cagggctggg agctctgcag tccttgaacc tcagtgagaa cggtttgtcc     3360

ctggatgccg tgttgggttt ggttcggtgc ttctccactc tgcagtggct cttccgcttg     3420

gacatcagct ttgaaagcca acacatcctc ctgagagggg acaagacaag cagggatatg     3480

tgggccactg gatctttgcc agacttccca gctgcagcca agttcttagg gttccgtcag     3540

cgctgcatcc ccaggagcct ctgcctcagt gagtgtcctc tggagccccc aagcctcacc     3600

cgcctctgtg ccactctgaa ggactgcccg ggacccctgg aactgcaatt gtcctgtgag     3660

ttcctgagtg accagagcct ggagactcta ctggactgct tacctcaact ccctcagctg     3720

agcctgctgc agctgagcca gacgggactg tccccgaaaa gccccttcct gctggccaac     3780

accttaagcc tgtgtccacg ggttaaaaag gtggatctca ggtccctgca ccatgcaact     3840

ttgcacttca gatccaacga ggaggaggaa ggcgtgtgct gtggcaggtt cacaggctgc     3900

agcctcagcc aggagcacgt agagtcactc tgctggttgc tgagcaagtg taaagacctc     3960

agccaggtgg atctctcagc aaacctgctg ggcgacagcg gactcagatg ccttctggaa     4020

tgtctgccgc aggtgcccat ctccggtttg cttgatctga gtcacaacag catttctcag     4080

gaaagtgccc tgtacctgct ggagacactg ccctcctgcc cacgtgtccg ggaggcctca     4140

gtgaacctgg gctctgagca gagcttccgg attcacttct ccagagagga ccaggctggg     4200

aagacactca ggctaagtga gtgcagcttc cggccagagc acgtgtccag gctggccacc     4260

ggcttgagca agtccctgca gctgacggag ctcacgctga cccagtgctg cctgggccag     4320

aagcagctgg ccatcctcct gagcttggtg gggcgacccg cagggctgtt cagcctcagg     4380

gtgcaggagc cgtgggcgga cagagccagg gttctctccc tgttagaagt ctgcgcccag     4440

gcctcaggca gtgtcactga aatcagcatc tccgagaccc agcagcagct ctgtgtccag     4500

ctggaatttc ctcgccagga agagaatcca gaagctgtgg cactcaggtt ggctcactgt     4560

gaccttggag cccaccacag ccttcttgtc gggcagctga tggagacatg tgccaggctg     4620

cagcagctca gcttgtctca ggttaacctc tgtgaggacg atgatgccag ttccctgctg     4680

ctgcagagcc tcctgctgtc cctctctgag ctgaagacat ttcggctgac ctccagctgt     4740

gtgagcaccg agggcctcgc ccacctggca tctggtctgg gccactgcca ccacttggag     4800

gagctggact tgtctaacaa tcaatttgat gaggagggca ccaaggcgct gatgagggcc     4860

cttgagggga aatggatgct aaagaggctg gacctcagtc accttctgct gaacagctcc     4920

accttggcct tgcttactca cagactaagc cagatgacct gcctgcagag cctcagactg     4980

aacaggaaca gtatcggtga tgtcggttgc tgccaccttt ctgaggctct cagggctgcc     5040

accagcctag aggagctgga cttgagccac aaccagattg gagacgctgg tgtccagcac     5100

ttagctacca tcctgcctgg gctgccagag ctcaggaaga tagacctctc agggaatagc     5160

atcagctcag ccgggggagt gcagttggca gagtctctcg ttctttgcag gcgcctggag     5220

gagttgatgc ttggctgcaa tgccctgggg gatcccacag ccctggggct ggctcaggag     5280

ctgccccagc acctgagggt cctacaccta ccattcagcc atctgggccc aggtggggcc     5340

ctgagcctgg cccaggccct ggatggatcc ccccatttgg aagagatcag cttggcggaa     5400

aacaacctgg ctggaggggt cctgcgtttc tgtatggagc tcccgctgct cagacagata     5460

gacctggttt cctgtaagat tgacaaccag actgccaagc tcctcacctc cagcttcacg     5520

agctgccctg ccctggaagt aatcttgctg tcctggaatc tcctcgggga tgaggcagct     5580

gccgagctgg cccaggtgct gccgcagatg ggccggctga agagagtgga cctggagaag     5640

aatcagatca cagctttggg ggcctggctc ctggctgaag gactggccca ggggtctagc     5700

atccaagtca tccgcctctg gaataacccc attccctgcg acatggccca gcacctgaag     5760

agccaggagc ccaggctgga ctttgccttc tttgacaacc agccccaggc cccttggggt     5820

acttgatggc cccctcaaga cctttggaat ccagccaagt gatgcaccca aatgatccac     5880

ctttcgccca ctgggataat tgactcagga aagaagagcc tcggcagggc gctctgcact     5940

ccacccagga ggaaggatac gtgtgtcctg ctgcagtcct cagggagaac ttttttggga     6000

accaggagct gggtctggac aaaggagtac cctgcattac gtgggatatg tgtgatcaat     6060

tggggacatg cgacacacaa tgagggtgtc atgacaatgc atgacacgta cggttatatg     6120

tggcagtgtg accccttgac atgtggcgtt acatgaaagt cagtgtggca cgtgttctgt     6180

ggcatgggtg ctggcatccc aagtagcagg atacatgatt gttggtctat atatgacaca     6240

tgacaaatgt ccatgtcaca ggactcatgg ctggccagat gacctcaggc tggcccaaga     6300

tctaatttat taatttttaa agcaaataca tatttataga ttgtgtgtat ggagcagcta     6360

agtcaggaaa agtcttccgc ccgagctggg aggggagagt gtccatgcac tgaccagtcc     6420

aggggctcaa gggccagggc tctggaacaa gccagggact cagccattaa gtcccctcct     6480

gcctcaatcc tcagcctacc catctataaa cttgatgact cctcccttac ttacatacta     6540

gcttccaagg acaggtggag gtagggccag cctggcggga gtggagaagc ccagtctgtc     6600

ctatgtaagg gacaaagcca ggtctaatgg tactgggtag ggggcactgc caagacaata     6660

agctaggcta ctgggtccag ctactacttt ggtgggattc aggtgagtct ccatgcactt     6720

cacatgttac ccagtgttct tgttacttcc aaggagaacc aagaatggct ctgtcacact     6780

cgaagccagg cttgatcaat aaacacaatg gtattccacg tc                        6822


<210>  11
<211>  5673
<212>  DNA
<213>  Chicken

<400>  11
ctagggatcc acacagagtg aggatgctgc atataggcac gcaccttgtg ttggggtgtt       60

gctgtgtgct gaaactctgc cactggtaga ccacttcttt ggcaggatat ggaggaggaa      120

gcacctttgt atttgcatat gctgctggat tgcacttagg acgactgaag ggaggctgac      180

cacacagcaa tgcagcccac actccagaac gatgacttca acctggaagg agctgtagca      240

agcatccgcc cccagctagt ggagttcctc agccatcgtc tcgactggct gctctctgct      300

tcccagcact tcctccctac ggctgtcctc agcggcttgg caggcgtcac tgaccacaga      360

gagaaagtct ctgtgctcct cgacctgctg gagaaggctg gccatgccac ctggaaacag      420

tttgcacagt gcctctgcat ggagtgtgac ctgcccctgg aaatggagat actgctcatg      480

agttctgcag gagaaggtaa cttgactcag aagcaagaag ctcagacaga cgcaagtgac      540

cagtcctctg tgccaagagg gttgacgcgc cgccgccgta gcagcagccc catcagtgat      600

aagggtgcta aacagaaacg cctggactca gctgaaaagt atcaacgtct tctcgttgac      660

tccatctgca agagatatgg aagcaggaga gcagcaggag cagcggcaca agagccaacg      720

cagcctctgg ctttcagcca agcctttgtc aacctcgttc ttcggcagag caaggcctcc      780

cgactgaaag agagaacaga caaaccccgg gaggacgtgc ccagtgcccc cgagccagaa      840

gaatgtgtgg atacagccgt gagagtgtca gatctctttg gcagcgtggt ccgatcgggt      900

acaacgaagg tgatcttttt gtttggtaaa ccaggtacag gcaagaccat gctgatgcac      960

aggatttgtc agaagtgggc ggaaggtgtc ttacatcagt ttctcttcac tttcctgttt     1020

gagttccggc agttgaattt actaaaaaga aaactgactc tgaaggagct tttgtttgac     1080

ctgtttcttc agccagaaga cagccccgat gcagtgttcc agcacctcct ggaaaacgcc     1140

caacgtacac tgatcatctt tgatgggctg gatgagtttg tgggtaacat ggacgtgtca     1200

tcagcttcta aaggaagcct gaaccgtagc tccagtatgt ccatatctga actctttgca     1260

gagctttgtc atgggaacct cctacctggc tgcacggtgt tggtcaccag ccgccctaag     1320

agagtccctg acttcttgat aaacacagta gatttgctgg cagaagtttg ggggtttgat     1380

cacgagaagg ttgaggagta tgtcagccac tattttcgtc atcattcatt caaagaacaa     1440

gccatcgctc acctgaagaa caacaccaag ctcctcagca tgtgccagat ccctgccctg     1500

tgttacgttg tctgcatctg tttggagtat ttgctcctta agcatcagac gagcgtggag     1560

cttccccaga ccatgacaca gttttatatc aaaatgcttc tcatcttcat aaacaaacag     1620

cagggggagc atgcaggtga tgaggaggct cagctgaaca gtaacaagaa ggccattttg     1680

ggtctgtgtg atcttgcact gaaaggcctg gaagctaaga agctcgtgtt ttacgttgga     1740

gatattccag agcacgtgaa agagtttgct tccttgcacg gtctgctgac tgtctttgag     1800

gtgaagacaa acagcgctca ccccgagact ggctatgcct ttgtgcactt gagcctgcag     1860

gagttttttg cagccctgtg tctcatgata agcaagagtg tggacaagag ccacctgaag     1920

aggaagttat ctctgaagtc aaagtggacg ttaaggaatg aagcaaagac tgggttcatg     1980

gagagctttc acatcttcct ctcaggcttg tcatccaagg agtgtaggac gtttatcatg     2040

ttgctagctg aacaaagtga agcttgggtg caggataagc aagatgcaat ccttcagtcc     2100

ctcaagaaac tggcagccac tcagctgacc gggcccaaag tcattgagct ctgccattgc     2160

acgtttgaaa cgcaaggcct cgaagtagcc cagcacattg ggagcctgct gaatttcaag     2220

tacgagttta aaaacttcag actgacacct ctggacatgt cggctttggt ttttgtcatc     2280

aactcgggcc aggatgtgac tcacttggat tttgcagggt gtcccttaga cacggactgt     2340

ttggagatgc tggccagctg taggaatgtg gagcatctga gctttcggag taggagattt     2400

ggtgatgact ttgctgctgc gctttcaaag ggcttaggag aaatggggag cctgaagaaa     2460

ctagaggtga caggtggaag catcacagct gcggggctga ctgacatggt ccaagctttg     2520

tcacactgcc tgcagctcga ggaaataaac ttgcaggaca atcggataca gaatccagac     2580

gtaaagacag tgatggagct gttttccaga atggaaaagc tgaagaaaat agatctgagc     2640

aagaacagtc tttccttgaa tgctgttctc cttttggcaa aggagttcat cgcgtgtcag     2700

aatgctgctg agctacacgt caggaaggac actgtgataa tatctttctc gggcccatct     2760

gggaaagttc caaggtcttt ggatttgaag cgggaacaaa acaaggaatg tgtgactcca     2820

actagacatc tgaggttgtg cttgcaggct cgctgcttgt cttcacaaca tgcaaaggag     2880

attgtgtcca ttctgcagag ctgcccacac ctctctgaag tagatttatc agataacaag     2940

cttggggatg aaggctgcag tttcctgctg gaaaacctct cctggatttc aatttcaaag     3000

cagctgaacc tttatcataa cactgcagtc ctgaggttta cagaagatgg agaatttgct     3060

tcccctcctg ctagtaggga agagcctttg taccctactg atgaccagtg ggatgacaaa     3120

gaaaaccaga cacctgttcc ctccaaaaaa ataagattga catactgtcg ttttcaagcc     3180

agtgacctgg agaagctgtg tgcagtcctg aaggaatgtg gcagcatctc tgagctggag     3240

ctaaataaca atcacctctc cctgagctct gtgttctgct tagctcagtc cttgtgtaca     3300

ctggaacact tggaaacaat ggacctcagc ttaggacgca tgcaggtggt tcatctaacc     3360

tttggggaca gaatcaggct cagaaggacc agcagatgga gaagttgttt cctggtgcat     3420

ccgaagcacg taacaaatgg acagtgcttt cgtctcagga actgcacggt gggtcctgag     3480

gacgtgacca ggctctgcca gatgctgatg cagtgtaccc agctgacgga aatcgatctg     3540

tgtggaaatg cactgaatga ccaaagcatt gagagattac tgagcttcct gccacacttc     3600

tgccagctga cactactgag tattaggaac aacacctttt ccccatgttg tgctgtatta     3660

tttgccaact cgatcaatct ctgtgagcgc atcagaaggg tggaagtccg gtcaagtcag     3720

aatgcttttt tacacttaag aacaagcacg cagggccaga agacatcctg caggctgact     3780

gactgtgcca tcggccaaag gcagatagag aagctctgca gagtcctgga gcagcatggg     3840

tgtctggcag aactagatct ctccaggaat cagctgggag atgaagtctt gaggttcctc     3900

ttggaccact tgcatcgagt gcctgttacc tgttctctca atctcagcca taataggatt     3960

tctcagcgtg gagttctgca tctcataaat acttttacca cttctggaaa taccaccgaa     4020

gtccaggtca gtctgtgctc caaggcaact ttaatcatca agatgacaag cagagatgac     4080

ccaagaaaga ttttgaggct cacagagtgc agctttcagc cagaacactt ggaaaagcta     4140

tgtttggttc tggagaactg caccaatctg acagagtgca tatcctccaa caacaacgtg     4200

acagtcgatg ctgcaggggg gcttttacgt tcactgagta aaactccagg tcctctaaaa     4260

atcagcatag aagagccctg ggtatgtaag ttgagtgtca cgagccttct tgagctggct     4320

gtccaggccc atggaaacat cactgcgatc atgatatgca aagagaagaa cctcttccaa     4380

ctaggtgtaa ggcttccaca ctgcctggag aaggtgggat cagtcgttag cagattgaat     4440

ttgaacgagc cagaaatcaa acaggcttgc ttctaccaaa gggttcatga caaatgcacc     4500

cagcttcagg aactgagatg gtctcacgtt gaactccacg atgacacaga aatgctcgtc     4560

agtattttgc tacctcttcc agatctgaag aagtttgagc tgacctcttg cagctttaca     4620

ccaactggaa ttgattgctt gatcacaggc ttgcagaggt gccaggccat tgaagagctc     4680

aacctgggcc acatgaagct cggcgatgct gccattccta agctagtgtt tggactctgt     4740

gaaatgccgt ctctgaaaag gctgatcttg aaccataaca gtattggtga cgatggctgc     4800

tccagactcg cagaagccct gagcagcatg cactgcatgg aagaaatcaa tttaggccac     4860

aacaagattg gagatctagg cctgataaat atagctgctg tcctgctgga aatgcaaaac     4920

ttgaagagaa tcgacctctc agggaactgt cccagtcctg ctggaggaga aaagctgatg     4980

gaagctcttg ccaattgcaa gcacctcgag gagctaattt tatctgaaaa caaccttggg     5040

gaaggaggta tccgtgccct gtccgagggg ctgccgcgtt ttgagcacct ccggaagatt     5100

gagttgagac tctgtggaat cactgatgat gcttcaaaat tactctctcg tggcttccag     5160

caatgccctg ctgtggagga gatcatattg tcttggaacg cccttggtga tggaggagcc     5220

caagtgttgg ccagcatcct cccagggatg gaaacgctga agatgttaga cctggagaaa     5280

aatctcattg gtgcgtgtgg tgctaccagg ttggcagagg aacttgtcag gtgcccagaa     5340

attcagttca taaggctgtg ggacaatccg gtgcccaaag gcctcgctga aagtttgaca     5400

agccaagacc caagactgtg cttctccttc tgttagcgaa ggacagccct cacctgatag     5460

aaattgctct ccgtttccca ttggcctcaa gaattgcact aaaagggatc ctgaagaacc     5520

caggaaacca aaattcctcc agttaaaacc tgtaattatg tcttccttca ttgcactgga     5580

tgaaatgtga gcacttacgt gtgttttgtt tatggtgagc ttttattttg aaccaaaaga     5640

ctgaagaact gctgctgagc aggcagcatt ctc                                  5673


<210>  12
<211>  1915
<212>  PRT
<213>  Mouse

<400>  12

Met Asp Ala Glu Ser Ile Arg Leu Asn Asn Glu Asn Leu Trp Ala Trp 
1               5                   10                  15      


Leu Val Arg Leu Leu Ser Lys Asn Pro Glu Trp Leu Ser Ala Lys Leu 
            20                  25                  30          


Arg Ser Phe Leu Pro Thr Met Asp Leu Asp Cys Ser Tyr Glu Pro Ser 
        35                  40                  45              


Asn Pro Glu Val Ile His Arg Gln Leu Asn Arg Leu Phe Ala Gln Gly 
    50                  55                  60                  


Met Ala Thr Trp Lys Ser Phe Ile Asn Asp Leu Cys Phe Glu Leu Asp 
65                  70                  75                  80  


Val Pro Leu Asp Met Glu Ile Pro Leu Val Ser Ile Trp Gly Pro Arg 
                85                  90                  95      


Asp Glu Phe Ser Lys Gln Leu Gly Ala Gly Glu Glu Ser Cys Pro Gly 
            100                 105                 110         


Pro Gln Leu Tyr His Gly Ala Lys Arg Pro Phe Gln Ser Tyr Gly Ser 
        115                 120                 125             


Ser Pro Arg Arg Lys Asn Ser Lys Lys Gln Gln Leu Glu Leu Ala Lys 
    130                 135                 140                 


Lys Tyr Leu Lys Leu Leu Lys Thr Ser Ala Gln Gln Trp His Gly Gly 
145                 150                 155                 160 


Val Cys Pro Gly Ala Trp Leu Thr Pro His Ser Pro Gln Thr Tyr Ile 
                165                 170                 175     


Pro Pro Val Leu Gln Trp Ser Arg Ala Thr Ala Pro Leu Asp Ala Gln 
            180                 185                 190         


Glu Gly Ala Thr Leu Gly Asp Pro Glu Ala Ala Asp Asn Ile Asp Val 
        195                 200                 205             


Ser Ile Gln Asp Leu Phe Ser Phe Lys Ala His Lys Gly Pro Arg Val 
    210                 215                 220                 


Thr Val Leu Leu Gly Lys Ala Gly Met Gly Lys Thr Thr Leu Ala Tyr 
225                 230                 235                 240 


Arg Leu Arg Trp Arg Trp Ala Gln Gly Gln Leu Asp Arg Phe Gln Ala 
                245                 250                 255     


Leu Phe Leu Phe Glu Phe Arg Gln Leu Asn Met Ile Thr Gln Leu Pro 
            260                 265                 270         


Thr Leu Pro Gln Leu Leu Phe Asp Leu Tyr Leu Met Pro Glu Ser Glu 
        275                 280                 285             


Pro Asp Ala Val Phe Gln Tyr Leu Lys Glu Asn Ala Gln Glu Val Leu 
    290                 295                 300                 


Leu Ile Phe Asp Gly Leu Asp Glu Ala Leu His Ala Asp Ser Val Gly 
305                 310                 315                 320 


Thr Asp Asn Ala Gly Ser Ala Leu Thr Leu Phe Ser Glu Leu Cys His 
                325                 330                 335     


Gly Asn Leu Leu Pro Gly Cys Trp Val Met Thr Thr Ser Arg Pro Gly 
            340                 345                 350         


Lys Leu Pro Ser Cys Val Pro Thr Glu Ala Ala Thr Val His Met Trp 
        355                 360                 365             


Gly Phe Asp Gly Leu Arg Val Glu Lys Tyr Val Thr Cys Phe Phe Ser 
    370                 375                 380                 


Asp Leu Leu Ser Gln Glu Leu Ala Leu Lys Glu Met Arg Thr Asn Ala 
385                 390                 395                 400 


Arg Leu Arg Gly Met Cys Ala Ile Pro Ala Leu Cys Thr Val Thr Cys 
                405                 410                 415     


Phe Cys Leu Arg Arg Leu Leu Pro Gly Ser Ser Pro Gly Gln Ser Ala 
            420                 425                 430         


Ala Leu Leu Pro Thr Ile Thr Gln Leu Tyr Leu Gln Met Val Glu Thr 
        435                 440                 445             


Phe Ser Pro Ser Glu Thr Leu Leu Asp Thr Ser Ile Leu Gly Phe Gly 
    450                 455                 460                 


Lys Val Ala Leu Arg Gly Leu Asp Thr Gly Lys Val Val Phe Ser Val 
465                 470                 475                 480 


Glu Asp Ile Ser Pro Gln Leu Met Ser Phe Gly Ala Val His Ser Leu 
                485                 490                 495     


Leu Thr Ser Phe Cys Ile His Thr Arg Pro Gly His Glu Glu Ile Gly 
            500                 505                 510         


Tyr Ala Phe Val His Leu Ser Leu Gln Glu Phe Phe Ala Ala Leu Tyr 
        515                 520                 525             


Leu Met Ala Ser His Thr Val Asp Lys Asp Thr Leu Val Glu Tyr Val 
    530                 535                 540                 


Thr Leu Asn Ser His Trp Val Leu Arg Thr Lys Gly Arg Leu Gly Leu 
545                 550                 555                 560 


Ser Asp His Leu Pro Ala Phe Leu Ala Gly Leu Ala Ser His Thr Cys 
                565                 570                 575     


His Met Phe Leu Cys Gln Leu Ala Gln Gln Asp Arg Ala Trp Val Gly 
            580                 585                 590         


Ser Arg Gln Ala Ala Val Ile Gln Val Leu Arg Lys Leu Ala Ser Arg 
        595                 600                 605             


Lys Leu Thr Gly Pro Lys Met Ile Glu Leu Tyr His Cys Val Ala Glu 
    610                 615                 620                 


Thr Gln Asp Leu Glu Leu Ala Arg Phe Thr Ala Gln Ser Leu Pro Ser 
625                 630                 635                 640 


Arg Leu Ser Phe His Asn Phe Pro Leu Thr His Ala Asp Leu Ala Ala 
                645                 650                 655     


Leu Ala Asn Ile Leu Glu His Arg Asp Asp Pro Ile His Leu Asp Phe 
            660                 665                 670         


Asp Gly Cys Pro Leu Glu Pro His Cys Pro Glu Ala Leu Val Gly Cys 
        675                 680                 685             


Gly Gln Val Glu Asn Leu Ser Phe Lys Ser Arg Lys Cys Gly Asp Ala 
    690                 695                 700                 


Phe Ala Glu Ala Leu Cys Arg Ser Leu Pro Thr Met Gly Ser Leu Lys 
705                 710                 715                 720 


Thr Leu Gly Leu Thr Gly Ser Arg Ile Thr Ala Gln Gly Ile Ser His 
                725                 730                 735     


Leu Ile Gln Thr Leu Pro Leu Cys Ser Gln Leu Glu Glu Val Ser Leu 
            740                 745                 750         


His Asp Asn Gln Leu Lys Asp Pro Glu Val Leu Ser Leu Val Glu Leu 
        755                 760                 765             


Leu Pro Ser Leu Pro Lys Leu Gln Lys Leu Asp Leu Ser Arg Asn Ser 
    770                 775                 780                 


Phe Ser Arg Ser Ile Leu Leu Ser Leu Val Lys Val Ala Ile Thr Cys 
785                 790                 795                 800 


Pro Thr Val Arg Lys Leu Gln Val Arg Glu Leu Asp Leu Ile Phe Tyr 
                805                 810                 815     


Leu Ser Pro Val Thr Glu Thr Ala Thr Gln Gln Ser Gly Ala Ser Asp 
            820                 825                 830         


Val Gln Gly Lys Asp Ser Leu Lys Glu Gly Gln Ser Arg Ser Leu Gln 
        835                 840                 845             


Leu Arg Leu Gln Lys Cys Gln Leu Arg Ile Arg Asp Ala Glu Ala Leu 
    850                 855                 860                 


Val Glu Leu Phe Gln Lys Ser Pro Gln Leu Glu Glu Val Asn Leu Ser 
865                 870                 875                 880 


Gly Asn His Leu Glu Asp Asp Gly Cys Arg Leu Val Ala Glu Ala Ala 
                885                 890                 895     


Ser Gln Leu His Ile Ala Gln Lys Leu Asp Leu Ser Asp Asn Gly Leu 
            900                 905                 910         


Ser Gln Thr Gly Val Thr Tyr Val Leu Lys Ala Met Ser Thr Cys Gly 
        915                 920                 925             


Thr Leu Glu Asp Leu His Ile Ser Leu Leu Asn Asn Thr Val Val Leu 
    930                 935                 940                 


Thr Phe Ala Gln Glu Pro Arg Glu Gln Glu Gly Ser Cys Lys Gly Arg 
945                 950                 955                 960 


Ala Pro Leu Ile Ser Phe Val Ser Pro Val Thr Ser Glu Leu Ser Gln 
                965                 970                 975     


Arg Ser Arg Arg Ile Arg Leu Thr His Cys Gly Phe Leu Ala Lys His 
            980                 985                 990         


Thr Glu Thr Leu Cys Glu Ala Leu  Arg Ala Ser Cys Gln  Thr His Asn 
        995                 1000                 1005             


Leu Asp  His Leu Asp Leu Ser  Asp Asn Ser Leu Gly  Gly Lys Gly 
    1010                 1015                 1020             


Val Ile  Leu Leu Thr Glu Leu  Leu Pro Gly Leu Gly  Pro Leu Lys 
    1025                 1030                 1035             


Ser Leu  Asn Leu Ser Arg Asn  Gly Leu Ser Met Asp  Ala Val Phe 
    1040                 1045                 1050             


Ser Leu  Val Gln Cys Leu Ser  Ser Leu Gln Trp Val  Phe His Leu 
    1055                 1060                 1065             


Asp Val  Ser Leu Glu Ser Asp  Cys Ile Phe Leu Arg  Gly Ala Gly 
    1070                 1075                 1080             


Thr Ser  Arg Asp Ala Leu Glu  Pro Lys Phe Gln Thr  Gly Val Gln 
    1085                 1090                 1095             


Val Leu  Glu Leu Ser Gln Arg  Tyr Thr Ser Arg Ser  Phe Cys Leu 
    1100                 1105                 1110             


Gln Glu  Cys Gln Leu Glu Pro  Thr Ser Leu Thr Phe  Leu Cys Ala 
    1115                 1120                 1125             


Thr Leu  Glu Lys Ser Pro Gly  Pro Leu Glu Val Gln  Leu Ser Cys 
    1130                 1135                 1140             


Lys Ser  Leu Ser Asp Asp Ser  Leu Lys Ile Leu Leu  Gln Cys Leu 
    1145                 1150                 1155             


Pro Gln  Leu Pro Gln Leu Ser  Leu Leu Gln Leu Arg  His Thr Val 
    1160                 1165                 1170             


Leu Ser  Ser Arg Ser Pro Phe  Leu Leu Ala Asp Ile  Phe Asn Leu 
    1175                 1180                 1185             


Cys Pro  Arg Val Arg Lys Val  Thr Leu Arg Ser Leu  Cys His Ala 
    1190                 1195                 1200             


Val Leu  His Phe Asp Ser Asn  Glu Glu Gln Glu Gly  Val Cys Cys 
    1205                 1210                 1215             


Gly Phe  Pro Gly Cys Ser Leu  Ser Gln Glu His Met  Glu Thr Leu 
    1220                 1225                 1230             


Cys Cys  Ala Leu Ser Lys Cys  Asn Ala Leu Ser Gln  Leu Asp Leu 
    1235                 1240                 1245             


Thr Asp  Asn Leu Leu Gly Asp  Ile Gly Leu Arg Cys  Leu Leu Glu 
    1250                 1255                 1260             


Cys Leu  Pro Gln Leu Pro Ile  Ser Gly Trp Leu Asp  Leu Ser His 
    1265                 1270                 1275             


Asn Asn  Ile Ser Gln Glu Gly  Ile Leu Tyr Leu Leu  Glu Thr Leu 
    1280                 1285                 1290             


Pro Ser  Tyr Pro Asn Ile Gln  Glu Val Ser Val Ser  Leu Ser Ser 
    1295                 1300                 1305             


Glu Gln  Ile Phe Arg Met Cys  Phe Ser Lys Lys Glu  Gly Ala Gly 
    1310                 1315                 1320             


Thr Ser  Leu Arg Leu Cys Glu  Cys Ser Phe Ser Pro  Glu Gln Val 
    1325                 1330                 1335             


Ser Lys  Leu Ala Ser Ser Leu  Ser Gln Ala Gln Gln  Leu Thr Glu 
    1340                 1345                 1350             


Leu Trp  Leu Thr Lys Cys His  Leu Asp Leu Pro Gln  Leu Thr Met 
    1355                 1360                 1365             


Leu Leu  Asn Leu Val Asn Arg  Pro Thr Gly Leu Leu  Gly Leu Arg 
    1370                 1375                 1380             


Leu Glu  Glu Pro Trp Val Asp  Ser Val Ser Leu Pro  Ala Leu Met 
    1385                 1390                 1395             


Glu Val  Cys Ala Gln Ala Ser  Gly Cys Leu Thr Glu  Leu Ser Ile 
    1400                 1405                 1410             


Ser Glu  Ile Gln Arg Lys Leu  Trp Leu Gln Leu Glu  Phe Pro His 
    1415                 1420                 1425             


Gln Glu  Gly Asn Ser Asp Ser  Met Ala Leu Arg Leu  Ala His Cys 
    1430                 1435                 1440             


Asp Leu  Glu Thr Glu His Ser  His Leu Met Ile Gln  Leu Val Glu 
    1445                 1450                 1455             


Thr Tyr  Ala Arg Leu Gln Gln  Leu Ser Leu Ser Gln  Val Ser Phe 
    1460                 1465                 1470             


Asn Asp  Asn Asp Gly Thr Ser  Ser Lys Leu Leu Gln  Asn Ile Leu 
    1475                 1480                 1485             


Leu Ser  Ser Cys Glu Leu Lys  Ser Phe Arg Leu Thr  Phe Ser Gln 
    1490                 1495                 1500             


Val Ser  Thr Lys Ser Leu Thr  His Leu Ala Phe Gly  Leu Gly His 
    1505                 1510                 1515             


Cys His  His Leu Glu Glu Leu  Asp Phe Ser Asn Asn  Ser Leu Arg 
    1520                 1525                 1530             


Glu Glu  Asp Thr Glu Leu Leu  Met Gly Ala Leu Gln  Gly Thr Cys 
    1535                 1540                 1545             


Arg Leu  Lys Lys Leu His Leu  Ser Phe Leu Pro Leu  Gly Ala Ser 
    1550                 1555                 1560             


Ser Leu  Ala Leu Leu Ile Gln  Gly Leu Ser Arg Met  Thr Leu Leu 
    1565                 1570                 1575             


Gln Asp  Leu Cys Leu Ser His  Asn Gln Ile Gly Asp  Val Gly Thr 
    1580                 1585                 1590             


Gln Cys  Leu Ala Ala Ile Leu  Pro Lys Leu Pro Glu  Leu Arg Lys 
    1595                 1600                 1605             


Phe Asp  Leu Ser His Asn Gln  Ile Gly Asp Val Gly  Thr Gln Cys 
    1610                 1615                 1620             


Leu Ala  Ala Ile Leu Pro Lys  Leu Pro Glu Leu Arg  Lys Phe Asn 
    1625                 1630                 1635             


Leu Ser  His Asn Gln Ile Gly  His Val Gly Thr Gln  Cys Leu Ala 
    1640                 1645                 1650             


Ala Ile  Leu Pro Lys Leu Pro  Glu Leu Arg Lys Phe  Asp Leu Ser 
    1655                 1660                 1665             


Arg Asn  Gln Ile Gly Asp Val  Gly Thr Gln Cys Leu  Ala Ala Ile 
    1670                 1675                 1680             


Leu Pro  Lys Leu Pro Glu Leu  Arg Lys Phe Asp Leu  Ser Gly Asn 
    1685                 1690                 1695             


Arg Ile  Gly Pro Ala Gly Gly  Val Gln Leu Val Lys  Ser Leu Thr 
    1700                 1705                 1710             


His Phe  Glu His Leu Glu Glu  Ile Lys Leu Gly Asn  Asn Ala Leu 
    1715                 1720                 1725             


Gly Glu  Pro Thr Ala Leu Glu  Leu Ala Gln Arg Leu  Pro Pro Gln 
    1730                 1735                 1740             


Leu Arg  Val Leu Cys Leu Pro  Ser Ser His Leu Gly  Pro Glu Gly 
    1745                 1750                 1755             


Ala Leu  Gly Leu Ala Gln Ala  Leu Glu Gln Cys Pro  His Ile Glu 
    1760                 1765                 1770             


Glu Val  Ser Leu Ala Glu Asn  Asn Leu Ala Gly Gly  Val Pro Arg 
    1775                 1780                 1785             


Phe Ser  Lys Arg Leu Pro Leu  Leu Arg Gln Ile Asp  Leu Glu Phe 
    1790                 1795                 1800             


Cys Lys  Ile Glu Asp Gln Ala  Ala Arg His Leu Ala  Ala Asn Leu 
    1805                 1810                 1815             


Thr Leu  Phe Pro Ala Leu Glu  Lys Leu Leu Leu Ser  Gly Asn Leu 
    1820                 1825                 1830             


Leu Gly  Asp Glu Val Ala Ala  Glu Leu Ala Gln Val  Leu Pro Gln 
    1835                 1840                 1845             


Met Gly  Gln Leu Lys Lys Val  Asn Leu Glu Trp Asn  Arg Ile Thr 
    1850                 1855                 1860             


Ala Arg  Gly Ala Gln Leu Leu  Ala Gln Gly Leu Val  Gln Gly Ser 
    1865                 1870                 1875             


Cys Val  Pro Val Ile Arg Leu  Trp Asn Asn Pro Ile  Leu Asn Asp 
    1880                 1885                 1890             


Val Ala  Gln Ser Leu Gln Ser  Gln Glu Pro Arg Leu  Asp Phe Ser 
    1895                 1900                 1905             


Ile Thr  Asp Gln Gln Thr Leu  
    1910                 1915 


<210>  13
<211>  6945
<212>  DNA
<213>  Mouse

<400>  13
atggacgctg agagcatccg actgaacaat gaaaacctgt gggcctggct tgtgaggctg       60

ctgagcaaaa acccagaatg gctgagtgcc aagcttaggt ccttcctccc gaccatggac      120

ctggactgca gctatgagcc ctccaaccct gaggtcatcc accgtcagct caacaggctg      180

ttcgcccaag gcatggccac ctggaagtct ttcatcaatg atctgtgctt cgagcttgat      240

gtacctttgg acatggagat accactagtg agcatctggg gcccaagaga tgaattctct      300

aagcagctag gggcaggaga ggagagctgc cctggacctc agctgtacca tggtgccaaa      360

cgtccttttc agagctatgg gtcctcaccc cgtcggaaga acagcaagaa gcagcagctc      420

gagttggcca agaagtatct gaagctcctg aagacctctg cccaacagtg gcatggtggt      480

gtgtgcccag gagcatggct tactcctcac tccccacaga cctacatccc cccagttctt      540

cagtggagcc gggctacagc acccttggat gctcaggagg gagccacttt aggagaccct      600

gaagcagccg acaacattga tgtgagcatc caggatctct tcagcttcaa ggctcacaag      660

ggacctcgag tgacagtact actgggaaag gctgggatgg gtaagaccac tctggcatat      720

cggctccgct ggaggtgggc tcaaggtcag ctggaccgct tccaggctct gttcctgttt      780

gagttccgcc agctcaacat gatcacacag ttgccgaccc tgccccagct cctctttgat      840

ctgtacttga tgccagagtc agagcctgat gctgtttttc agtacctaaa ggagaatgct      900

caggaagtcc tactgatctt tgatgggttg gatgaggctc tccatgctga ttctgtgggt      960

actgacaatg caggctcggc cctcaccctc ttttctgaac tctgccatgg gaacctcctg     1020

ccaggctgct gggtgatgac cacctcccgt cctgggaaac tgccttcctg tgtgcccaca     1080

gaagcagcca cggtacacat gtggggcttt gatgggctac gagtagagaa gtatgttacc     1140

tgcttcttca gtgatcttct gtctcaggaa ttggccttga aggaaatgag aaccaatgca     1200

cgtctccggg gtatgtgtgc aatacctgcg ttgtgcacag tcacctgctt ctgccttcgc     1260

cgtctgcttc ctggaagctc cccagggcag tctgcagccc tcctgcccac cataacccag     1320

ttgtacctgc agatggtgga aacttttagc cccagtgaga ctctgcttga cacatccatt     1380

ttgggctttg gaaaggtggc ccttagggga ctggacactg ggaaagtcgt cttctctgtg     1440

gaagacatct ctccccaact gatgtctttt ggagctgtcc acagcctcct gacctccttc     1500

tgtatccaca cccgccctgg gcatgaagaa ataggctatg cttttgtcca ccttagcctg     1560

caggagttct ttgctgctct gtatctgatg gccagtcaca cagtggacaa agacacactc     1620

gtcgagtatg tcaccctcaa ttcccactgg gtgctgagga ccaaaggtag actgggcctc     1680

tcggatcatc tccctgcctt cctggcaggc ctagcctccc acacctgcca catgttcctc     1740

tgccaactgg ctcagcaaga cagagcctgg gtgggctcca ggcaggccgc tgtgatccag     1800

gtgctaagga agttggctag ccggaaactc acagggccaa agatgataga gttgtatcac     1860

tgtgtggctg agacccagga tctggagctg gcgaggttca ctgcccaaag ccttccttcc     1920

cgcctctcct tccacaattt ccctctgacc catgcagacc tggctgcact ggctaacatt     1980

ttggagcaca gggatgatcc cattcacctg gattttgacg gctgcccact ggagccccac     2040

tgcccagagg ctctggtagg atgtgggcag gtggagaatc tcagctttaa aagcagaaag     2100

tgtggggatg cctttgcaga agccctctgc aggagtttgc ctactatggg gagcctgaag     2160

acgctggggt taacaggaag taggattaca gcccaaggca tcagccacct gatacagaca     2220

ttgcccctct gttcccagct ggaggaggtc agtttgcatg acaaccagct caaggaccca     2280

gaggtgctga gtcttgtgga gctgcttccc tccctgccga agctccagaa acttgacctg     2340

agccgaaaca gcttctccag gtcaatcctc ctgtctttgg tgaaagtggc tatcacatgt     2400

cctactgtca ggaagctgca ggtcagggaa ttggacctca tcttctatct gtccccagtc     2460

acagagacag ctacacagca atcaggagca tcagatgtac agggcaaaga cagcctgaag     2520

gaaggacaga gtcgaagcct gcaactcagg cttcagaaat gtcagctcag gatccgtgat     2580

gcagaagccc ttgtggagct attccagaaa agcccccagc tggaggaagt gaatctttca     2640

gggaaccatt tggaagatga tggctgtcga cttgtggcag aggctgcttc acagcttcac     2700

attgcccaga aactggacct cagcgacaat ggcctctctc agactggggt gacctatgtg     2760

ttgaaagcca tgagcacatg tgggaccctg gaagacctgc acatcagcct gctaaacaac     2820

accgtggtac tcacatttgc ccaggagccg agggagcagg aggggagctg caaggggagg     2880

gcaccactta tcagcttcgt gtctcctgtg acctccgagt tgtcccagag atctcgaagg     2940

atcaggctga cacactgtgg cttcctggcc aagcacacag agacgctctg tgaggcactg     3000

agagccagct gccagaccca caacctggat catcttgacc tatcagacaa ctctttgggg     3060

ggcaaaggag tgatcctgct aaccgagctg ctcccaggac tgggtcccct gaagtccttg     3120

aacctcagca ggaatggctt gtccatggat gctgtcttta gcttggtcca gtgtctgtct     3180

tccctgcagt gggtgttcca cttagatgtc agccttgaga gtgactgcat cttccttcga     3240

ggagctggga ccagcaggga tgcactagaa ccaaaattcc agactggagt ccaggtactg     3300

gagctgagtc agcggtacac ctcccggagc ttctgccttc aagagtgtca gttggaaccc     3360

acgagcctta ccttcctctg tgccactctg gagaagagcc cagggcctct ggaagtccaa     3420

ttgtcctgca agtccctgag tgatgacagc ctgaagatcc tgctgcagtg cctgccccag     3480

ctgcctcagc tcagcctgct gcagctgaga cacacagtcc tatcttcaag aagccccttc     3540

ctgctggctg acatcttcaa cctgtgccca cgggttcgga aggtcactct caggtcccta     3600

tgtcatgctg ttctgcactt tgactccaat gaggaacaag agggtgtgtg ctgtggcttc     3660

ccgggatgca gcctcagcca ggagcatatg gaaacactgt gctgtgcact gagcaagtgc     3720

aatgccctca gccagcttga tctcacagac aatctgctgg gtgacatcgg gctcaggtgc     3780

cttctggagt gcctgccaca gctgcccatc tctgggtggc ttgacctcag tcacaacaat     3840

atctctcagg aagggatcct gtacctgctg gagactctgc cttcctaccc taatatccaa     3900

gaggtctctg tgagtctgag ctctgagcag atcttccgaa tgtgcttctc caaaaaggaa     3960

ggagccggga catcgctgag gctatgtgaa tgcagcttca gcccagaaca agtatccaaa     4020

ttggcttcca gcctgagcca ggcccaacag ctcacagagc tctggctgac caagtgtcac     4080

ttggacctgc cacagctgac catgctcctg aacctggtga atcggccaac agggttgctg     4140

ggcctcaggt tggaagagcc ctgggtggac tctgtcagct taccagctct aatggaagtc     4200

tgtgcccagg cctcaggatg tctcactgag ttaagcatct ctgagatcca aaggaagttg     4260

tggctccagc tggaatttcc tcaccaagaa ggcaattctg attccatggc tctcaggttg     4320

gctcactgtg acctggagac cgagcacagc catcttatga tacagttggt ggagacatat     4380

gccagactgc agcagctgag cttgtctcag gttagcttca atgacaatga tggcaccagc     4440

tccaagctgc tgcagaacat cctgctatca agctgtgagc tgaagagctt caggctgacc     4500

ttcagccaag tgagcacaaa gagcctcacc catctggcat ttggtctggg acactgccac     4560

catctggaag agctggactt ctctaacaac agtctccgtg aggaggacac agagctactg     4620

atgggagccc ttcagggaac ctgcagactg aagaagctgc accttagttt cttaccattg     4680

ggagcctcct ctctggcctt gctcattcaa ggactaagcc gaatgactct actacaggac     4740

ctttgcttga gtcacaacca gatcggagat gtgggtaccc agtgcttagc tgccatcttg     4800

ccaaaactgc cagaactcag gaaatttgac ttgagtcaca accagatcgg agatgtgggt     4860

acccagtgct tagctgccat cttgccaaaa cttccagaac tcaggaaatt taacttgagt     4920

cacaaccaga tcggacatgt gggtacccag tgcttagctg ccatcttgcc aaaacttcca     4980

gaactcagga aatttgactt gagtcgcaac cagatcggag atgtgggtac ccagtgctta     5040

gctgccatct tgccaaaact tccagaactc aggaagtttg acctctcagg gaacaggatt     5100

ggcccagctg ggggagtgca gctggtgaag tctctcaccc atttcgagca cttggaggag     5160

atcaaactgg gcaacaatgc tctgggggag cccacagccc tggagctggc tcagagattg     5220

cccccacaac tcagggtcct gtgcctgcca tccagtcatc tgggtccaga gggggccctg     5280

ggcctggccc aggccctgga gcaatgccca cacatagaag aggtcagctt ggcagagaat     5340

aacctggctg gaggtgtccc acgtttctcc aagaggctcc cactgcttag acaaattgac     5400

ctggagttct gcaagattga agaccaagct gccaggcacc ttgctgccaa cctcacactc     5460

ttcccagccc tggagaaact cttgctgtcc gggaatctcc ttggagatga ggtggctgct     5520

gagttggccc aggtcctgcc gcagatggga cagctgaaga aagtgaactt ggagtggaac     5580

cggatcacag cacgtggagc ccaactcctg gctcaagggc tggtccaggg atcctgcgtc     5640

ccagtcattc gcctctggaa caaccccatt cttaacgatg tggcccagag tctgcagagc     5700

caggaaccca ggctggactt ctccatcact gaccagcaga ctctttgagg aacccaacgg     5760

acttctcaag acttatgagt ccagtccagt gacagccaca tcacccacca ggagaggggg     5820

ctcagaagaa cctctgttgg tgcccagcat cctacgaatg ccccaggagg aaagaacaca     5880

tttttcctgt cacgatccct agggagcgca ttcttaggga ctgagagctt tgtttgacca     5940

aaagagggcc atatatcata tatcatacat gacatatgtt accaatgggg cattgacatt     6000

atgagagtat tatgaggtta tatatacagg aaaggctgtg tatggtgcac tatgacccct     6060

tgacatggga aggtcatact cagagtaggt caaatgtaga attacatgga acttgtggca     6120

tgacacctgg tcatagcctc ttagcactgt aattggaaat acacatgatc aggaatccac     6180

ttatgacatg atgtccatat cacatgacac acaacttgac aggggaccac agataagtcc     6240

aagacctaat ttattattat tttaaaaaac atgaagttag gctaatggta taggctatgt     6300

tatatgaaca gccttttagc tgttcaggaa tctgaggcag acagatcgca agttcaaggt     6360

caatctaggt aatttagtaa gatcctgtct caaaaggtca gaaagggctg gggatatggc     6420

tcaatgctag agtgcttcct agcatgtgta aagccctaag ctcaatgctc ggtgcttttt     6480

ttttttttaa gtatttataa gcaccttctg gagaaacttt ttgtcttgtg ctaggagagg     6540

gagttaagaa ttgagtggcc caatggtccg gggtctggga catgccaagg acttagcatg     6600

aagtcccctc ctgccagagc ctcaagtctc tcttctgtta atcgtgttct tccaaggact     6660

tccagcccag gcttaggagt taacctgacc ttgggagagt tcgcactcat ctcttctttc     6720

ctggtttaag ggacaaagcc gagctacagg tttagggata agtacttcca ggataatagg     6780

caagaccact aggtctagcc tacccactac ctcagcagga ttcagaaacc acttgaaact     6840

ccatggtgtt ttgctttgtt ttgcaacttc caaaggctaa actcacaaca ctccatatca     6900

aatgatcaat aaacgcagat gtaactggtg tctgatgtaa acgcc                     6945


