                         SEQUENCE LISTING

<110>  Lusomedicamenta S.A.
 
<120>  ANTIBACTERIAL PHAGE PEPTIDES AND METHODS OF USE THEREOF

<130>  PPI 41012/09

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  756
<212>  DNA
<213>  Bacteriophage F87s/06

<400>  1
atgaaaacat acagtgaagc aagagcaagg ttacgttggt atcaaggtag atatattgat       60

tttgacggtt ggtatggtta ccaatgtgca gatttagcag ttgattacat ttattggttg      120

ttagaaatta gaatgtgggg aaatgcaaaa gatgcaatca ataacgattt taaaaacatg      180

gcaacagtat atgaaaacac accatcgttt gttccacaaa taggtgatgt ggctgtattt      240

accaaaggaa tatataaaca atacggtcat attggtttag tgtttaatgg tggtaataca      300

aaccaatttt taattttgga acagaactat gacggtaacg caaatacgcc tgcaaagtta      360

cgttgggata attattacgg ctgtactcac tttattagac ctaagtataa aagtgagggc      420

ttaatgaata agatcacaaa taaagttaaa ccacctgctc aaaaagcagt cggtaaatct      480

gcaagtaaaa taacagttgg aagtaaagcg ccttataacc ttaaatggtc aaaaggtgct      540

tattttaatg cgaaaatcga cggcttaggt gctacttcag ccactagata cggtgataat      600

cgtactaact atagattcga tgttggacag gctgtatacg cgcctggaac attaatatat      660

gtgtttgaaa ttatagatgg ttggtgtcgc atttattgga acaatcataa tgagtggata      720

tggcatgaga gattgattgt gaaagaagtg ttttaa                                756


<210>  2
<211>  251
<212>  PRT
<213>  Bacteriophage F87s/06

<400>  2

Met Lys Thr Tyr Ser Glu Ala Arg Ala Arg Leu Arg Trp Tyr Gln Gly 
1               5                   10                  15      


Arg Tyr Ile Asp Phe Asp Gly Trp Tyr Gly Tyr Gln Cys Ala Asp Leu 
            20                  25                  30          


Ala Val Asp Tyr Ile Tyr Trp Leu Leu Glu Ile Arg Met Trp Gly Asn 
        35                  40                  45              


Ala Lys Asp Ala Ile Asn Asn Asp Phe Lys Asn Met Ala Thr Val Tyr 
    50                  55                  60                  


Glu Asn Thr Pro Ser Phe Val Pro Gln Ile Gly Asp Val Ala Val Phe 
65                  70                  75                  80  


Thr Lys Gly Ile Tyr Lys Gln Tyr Gly His Ile Gly Leu Val Phe Asn 
                85                  90                  95      


Gly Gly Asn Thr Asn Gln Phe Leu Ile Leu Glu Gln Asn Tyr Asp Gly 
            100                 105                 110         


Asn Ala Asn Thr Pro Ala Lys Leu Arg Trp Asp Asn Tyr Tyr Gly Cys 
        115                 120                 125             


Thr His Phe Ile Arg Pro Lys Tyr Lys Ser Glu Gly Leu Met Asn Lys 
    130                 135                 140                 


Ile Thr Asn Lys Val Lys Pro Pro Ala Gln Lys Ala Val Gly Lys Ser 
145                 150                 155                 160 


Ala Ser Lys Ile Thr Val Gly Ser Lys Ala Pro Tyr Asn Leu Lys Trp 
                165                 170                 175     


Ser Lys Gly Ala Tyr Phe Asn Ala Lys Ile Asp Gly Leu Gly Ala Thr 
            180                 185                 190         


Ser Ala Thr Arg Tyr Gly Asp Asn Arg Thr Asn Tyr Arg Phe Asp Val 
        195                 200                 205             


Gly Gln Ala Val Tyr Ala Pro Gly Thr Leu Ile Tyr Val Phe Glu Ile 
    210                 215                 220                 


Ile Asp Gly Trp Cys Arg Ile Tyr Trp Asn Asn His Asn Glu Trp Ile 
225                 230                 235                 240 


Trp His Glu Arg Leu Ile Val Lys Glu Val Phe 
                245                 250     


<210>  3
<211>  894
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - Lysin 170-87

<400>  3
atggcaggag aagtatttag tagcttgatt acaagtgtaa atcctaaccc aatgaacgca       60

ggtagccgta atggtatcac tatcgacacc attatcctac atcacaatgc aacaacaaat      120

aaagatgttg ctatgaacac atggctatta ggtggtggcg caggtacatc tgctcattat      180

gaatgtacac caacagaaat tattggatgt gtcggtgagc agtattcagc attccatgcc      240

ggaggtacag gtggtataga cgttcctaag attgctaacc ctaatcaacg ttcaataggt      300

attgaaaatg taaactcgtc aggagcacct aattggtctg tagaccctag aacaattaca      360

aattgtgctc gtttagtggc agatatttgt acacgttatg gtattccgtg tgaccgacaa      420

catgtgttag gacataacga agtaactgca acagcatgtc ccggaggtat ggatgtagac      480

gaagttgtac gtcaagctca acagttcatg gcaggaggct ctaacaatgc agttaagccg      540

gagccaaaag ttaaaccacc tgctcaaaaa gcagtcggta aatctgcaag taaaataaca      600

gttggaagta aagcgcctta taaccttaaa tggtcaaaag gtgcttattt taatgcgaaa      660

atcgacggct taggtgctac ttcagccact agatacggtg ataatcgtac taactataga      720

ttcgatgttg gacaggctgt atacgcgcct ggaacattaa tatatgtgtt tgaaattata      780

gatggttggt gtcgcattta ttggaacaat cataatgagt ggatatggca tgagagattg      840

attgtgaaag aagtgtttcc cggggggggt tctcatcatc atcatcatca ttaa            894


<210>  4
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct - Lysin 170-87

<400>  4

Met Ala Gly Glu Val Phe Ser Ser Leu Ile Thr Ser Val Asn Pro Asn 
1               5                   10                  15      


Pro Met Asn Ala Gly Ser Arg Asn Gly Ile Thr Ile Asp Thr Ile Ile 
            20                  25                  30          


Leu His His Asn Ala Thr Thr Asn Lys Asp Val Ala Met Asn Thr Trp 
        35                  40                  45              


Leu Leu Gly Gly Gly Ala Gly Thr Ser Ala His Tyr Glu Cys Thr Pro 
    50                  55                  60                  


Thr Glu Ile Ile Gly Cys Val Gly Glu Gln Tyr Ser Ala Phe His Ala 
65                  70                  75                  80  


Gly Gly Thr Gly Gly Ile Asp Val Pro Lys Ile Ala Asn Pro Asn Gln 
                85                  90                  95      


Arg Ser Ile Gly Ile Glu Asn Val Asn Ser Ser Gly Ala Pro Asn Trp 
            100                 105                 110         


Ser Val Asp Pro Arg Thr Ile Thr Asn Cys Ala Arg Leu Val Ala Asp 
        115                 120                 125             


Ile Cys Thr Arg Tyr Gly Ile Pro Cys Asp Arg Gln His Val Leu Gly 
    130                 135                 140                 


His Asn Glu Val Thr Ala Thr Ala Cys Pro Gly Gly Met Asp Val Asp 
145                 150                 155                 160 


Glu Val Val Arg Gln Ala Gln Gln Phe Met Ala Gly Gly Ser Asn Asn 
                165                 170                 175     


Ala Val Lys Pro Glu Pro Lys Val Lys Pro Pro Ala Gln Lys Ala Val 
            180                 185                 190         


Gly Lys Ser Ala Ser Lys Ile Thr Val Gly Ser Lys Ala Pro Tyr Asn 
        195                 200                 205             


Leu Lys Trp Ser Lys Gly Ala Tyr Phe Asn Ala Lys Ile Asp Gly Leu 
    210                 215                 220                 


Gly Ala Thr Ser Ala Thr Arg Tyr Gly Asp Asn Arg Thr Asn Tyr Arg 
225                 230                 235                 240 


Phe Asp Val Gly Gln Ala Val Tyr Ala Pro Gly Thr Leu Ile Tyr Val 
                245                 250                 255     


Phe Glu Ile Ile Asp Gly Trp Cys Arg Ile Tyr Trp Asn Asn His Asn 
            260                 265                 270         


Glu Trp Ile Trp His Glu Arg Leu Ile Val Lys Glu Val Phe Pro Gly 
        275                 280                 285             


Gly Gly Ser His His His His His His 
    290                 295         


<210>  5
<211>  828
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - Lysin 168-87

<400>  5
atggttaaat taaatgatgt acttagctat gtcaacggac ttgtcggaaa aggcgtggac       60

gctgatggat ggtatggtac tcaatgtatg gacttgacag tagacgttat gcaacgcttc      120

ttcggatggc gcccgtacgg taatgcaatt gccttggttg accagcctat cccagcaggc      180

ttccaaagaa tccgtaccac aagctctaca caaatcaaag ctggtgacgt tatgatatgg      240

ggcttaggat actatgctca atacggtcac acaggaattg caacggagga tggaagagct      300

gacggaacct ttgtcagtgt tgaccaaaac tggattaacc caagccttga agtaggcagt      360

ccagcagctg ctatccacca caatatggat ggtgtctggg gagttatccg accaccttac      420

gaggctgaat caaagcctaa accacctgca ccaaaaccag ataaaccaaa tctaggacaa      480

aaagttaaac cacctgctca aaaagcagtc ggtaaatctg caagtaaaat aacagttgga      540

agtaaagcgc cttataacct taaatggtca aaaggtgctt attttaatgc gaaaatcgac      600

ggcttaggtg ctacttcagc cactagatac ggtgataatc gtactaacta tagattcgat      660

gttggacagg ctgtatacgc gcctggaaca ttaatatatg tgtttgaaat tatagatggt      720

tggtgtcgca tttattggaa caatcataat gagtggatat ggcatgagag attgattgtg      780

aaagaagtgt ttcccggggg gggttctcat catcatcatc atcattaa                   828


<210>  6
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct - Lysin 168-87

<400>  6

Met Val Lys Leu Asn Asp Val Leu Ser Tyr Val Asn Gly Leu Val Gly 
1               5                   10                  15      


Lys Gly Val Asp Ala Asp Gly Trp Tyr Gly Thr Gln Cys Met Asp Leu 
            20                  25                  30          


Thr Val Asp Val Met Gln Arg Phe Phe Gly Trp Arg Pro Tyr Gly Asn 
        35                  40                  45              


Ala Ile Ala Leu Val Asp Gln Pro Ile Pro Ala Gly Phe Gln Arg Ile 
    50                  55                  60                  


Arg Thr Thr Ser Ser Thr Gln Ile Lys Ala Gly Asp Val Met Ile Trp 
65                  70                  75                  80  


Gly Leu Gly Tyr Tyr Ala Gln Tyr Gly His Thr Gly Ile Ala Thr Glu 
                85                  90                  95      


Asp Gly Arg Ala Asp Gly Thr Phe Val Ser Val Asp Gln Asn Trp Ile 
            100                 105                 110         


Asn Pro Ser Leu Glu Val Gly Ser Pro Ala Ala Ala Ile His His Asn 
        115                 120                 125             


Met Asp Gly Val Trp Gly Val Ile Arg Pro Pro Tyr Glu Ala Glu Ser 
    130                 135                 140                 


Lys Pro Lys Pro Pro Ala Pro Lys Pro Asp Lys Pro Asn Leu Gly Gln 
145                 150                 155                 160 


Lys Val Lys Pro Pro Ala Gln Lys Ala Val Gly Lys Ser Ala Ser Lys 
                165                 170                 175     


Ile Thr Val Gly Ser Lys Ala Pro Tyr Asn Leu Lys Trp Ser Lys Gly 
            180                 185                 190         


Ala Tyr Phe Asn Ala Lys Ile Asp Gly Leu Gly Ala Thr Ser Ala Thr 
        195                 200                 205             


Arg Tyr Gly Asp Asn Arg Thr Asn Tyr Arg Phe Asp Val Gly Gln Ala 
    210                 215                 220                 


Val Tyr Ala Pro Gly Thr Leu Ile Tyr Val Phe Glu Ile Ile Asp Gly 
225                 230                 235                 240 


Trp Cys Arg Ile Tyr Trp Asn Asn His Asn Glu Trp Ile Trp His Glu 
                245                 250                 255     


Arg Leu Ile Val Lys Glu Val Phe Pro Gly Gly Gly Ser His His His 
            260                 265                 270         


His His His 
        275 


