                         SEQUENCE LISTING

<110>  PATERSON, Yvonne
       MACIAG, Paulo
       SEAVEY, Matthew
       FERRONE, Soldano
 
<120>  COMPOSITIONS COMPRISING HMW-MAA AND FRAGMENTS THEREOF, AND 
       METHODS OF USE THEREOF

<130>  P-8986-PC1

<140>  PCT/US09/999999
<141>  2009-10-02

<150>  12/244,828
<151>  2008-10-03

<150>  11/889,715
<151>  2007-08-15

<150>  60/837,608
<151>  2006-08-15

<160>  67    

<170>  PatentIn version 3.5

<210>  1
<211>  529
<212>  PRT
<213>  Listeria monocytogenes

<400>  1

Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu 
1               5                   10                  15      


Pro Ile Ala Gln Gln Thr Glu Ala Lys Asp Ala Ser Ala Phe Asn Lys 
            20                  25                  30          


Glu Asn Ser Ile Ser Ser Met Ala Pro Pro Ala Ser Pro Pro Ala Ser 
        35                  40                  45              


Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys Tyr 
    50                  55                  60                  


Ile Gln Gly Leu Asp Tyr Asn Lys Asn Asn Val Leu Val Tyr His Gly 
65                  70                  75                  80  


Asp Ala Val Thr Asn Val Pro Pro Arg Lys Gly Tyr Lys Asp Gly Asn 
                85                  90                  95      


Glu Tyr Ile Val Val Glu Lys Lys Lys Lys Ser Ile Asn Gln Asn Asn 
            100                 105                 110         


Ala Asp Ile Gln Val Val Asn Ala Ile Ser Ser Leu Thr Tyr Pro Gly 
        115                 120                 125             


Ala Leu Val Lys Ala Asn Ser Glu Leu Val Glu Asn Gln Pro Asp Val 
    130                 135                 140                 


Leu Pro Val Lys Arg Asp Ser Leu Thr Leu Ser Ile Asp Leu Pro Gly 
145                 150                 155                 160 


Met Thr Asn Gln Asp Asn Lys Ile Val Val Lys Asn Ala Thr Lys Ser 
                165                 170                 175     


Asn Val Asn Asn Ala Val Asn Thr Leu Val Glu Arg Trp Asn Glu Lys 
            180                 185                 190         


Tyr Ala Gln Ala Tyr Pro Asn Val Ser Ala Lys Ile Asp Tyr Asp Asp 
        195                 200                 205             


Glu Met Ala Tyr Ser Glu Ser Gln Leu Ile Ala Lys Phe Gly Thr Ala 
    210                 215                 220                 


Phe Lys Ala Val Asn Asn Ser Leu Asn Val Asn Phe Gly Ala Ile Ser 
225                 230                 235                 240 


Glu Gly Lys Met Gln Glu Glu Val Ile Ser Phe Lys Gln Ile Tyr Tyr 
                245                 250                 255     


Asn Val Asn Val Asn Glu Pro Thr Arg Pro Ser Arg Phe Phe Gly Lys 
            260                 265                 270         


Ala Val Thr Lys Glu Gln Leu Gln Ala Leu Gly Val Asn Ala Glu Asn 
        275                 280                 285             


Pro Pro Ala Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu 
    290                 295                 300                 


Lys Leu Ser Thr Asn Ser His Ser Thr Lys Val Lys Ala Ala Phe Asp 
305                 310                 315                 320 


Ala Ala Val Ser Gly Lys Ser Val Ser Gly Asp Val Glu Leu Thr Asn 
                325                 330                 335     


Ile Ile Lys Asn Ser Ser Phe Lys Ala Val Ile Tyr Gly Gly Ser Ala 
            340                 345                 350         


Lys Asp Glu Val Gln Ile Ile Asp Gly Asn Leu Gly Asp Leu Arg Asp 
        355                 360                 365             


Ile Leu Lys Lys Gly Ala Thr Phe Asn Arg Glu Thr Pro Gly Val Pro 
    370                 375                 380                 


Ile Ala Tyr Thr Thr Asn Phe Leu Lys Asp Asn Glu Leu Ala Val Ile 
385                 390                 395                 400 


Lys Asn Asn Ser Glu Tyr Ile Glu Thr Thr Ser Lys Ala Tyr Thr Asp 
                405                 410                 415     


Gly Lys Ile Asn Ile Asp His Ser Gly Gly Tyr Val Ala Gln Phe Asn 
            420                 425                 430         


Ile Ser Trp Asp Glu Val Asn Tyr Asp Pro Glu Gly Asn Glu Ile Val 
        435                 440                 445             


Gln His Lys Asn Trp Ser Glu Asn Asn Lys Ser Lys Leu Ala His Phe 
    450                 455                 460                 


Thr Ser Ser Ile Tyr Leu Pro Gly Asn Ala Arg Asn Ile Asn Val Tyr 
465                 470                 475                 480 


Ala Lys Glu Cys Thr Gly Leu Ala Trp Glu Trp Trp Arg Thr Val Ile 
                485                 490                 495     


Asp Asp Arg Asn Leu Pro Leu Val Lys Asn Arg Asn Ile Ser Ile Trp 
            500                 505                 510         


Gly Thr Thr Leu Tyr Pro Lys Tyr Ser Asn Lys Val Asp Asn Pro Ile 
        515                 520                 525             


Glu 
    


<210>  2
<211>  441
<212>  PRT
<213>  Listeria monocytogenes

<400>  2

Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu 
1               5                   10                  15      


Pro Ile Ala Gln Gln Thr Glu Ala Lys Asp Ala Ser Ala Phe Asn Lys 
            20                  25                  30          


Glu Asn Ser Ile Ser Ser Val Ala Pro Pro Ala Ser Pro Pro Ala Ser 
        35                  40                  45              


Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys Tyr 
    50                  55                  60                  


Ile Gln Gly Leu Asp Tyr Asn Lys Asn Asn Val Leu Val Tyr His Gly 
65                  70                  75                  80  


Asp Ala Val Thr Asn Val Pro Pro Arg Lys Gly Tyr Lys Asp Gly Asn 
                85                  90                  95      


Glu Tyr Ile Val Val Glu Lys Lys Lys Lys Ser Ile Asn Gln Asn Asn 
            100                 105                 110         


Ala Asp Ile Gln Val Val Asn Ala Ile Ser Ser Leu Thr Tyr Pro Gly 
        115                 120                 125             


Ala Leu Val Lys Ala Asn Ser Glu Leu Val Glu Asn Gln Pro Asp Val 
    130                 135                 140                 


Leu Pro Val Lys Arg Asp Ser Leu Thr Leu Ser Ile Asp Leu Pro Gly 
145                 150                 155                 160 


Met Thr Asn Gln Asp Asn Lys Ile Val Val Lys Asn Ala Thr Lys Ser 
                165                 170                 175     


Asn Val Asn Asn Ala Val Asn Thr Leu Val Glu Arg Trp Asn Glu Lys 
            180                 185                 190         


Tyr Ala Gln Ala Tyr Ser Asn Val Ser Ala Lys Ile Asp Tyr Asp Asp 
        195                 200                 205             


Glu Met Ala Tyr Ser Glu Ser Gln Leu Ile Ala Lys Phe Gly Thr Ala 
    210                 215                 220                 


Phe Lys Ala Val Asn Asn Ser Leu Asn Val Asn Phe Gly Ala Ile Ser 
225                 230                 235                 240 


Glu Gly Lys Met Gln Glu Glu Val Ile Ser Phe Lys Gln Ile Tyr Tyr 
                245                 250                 255     


Asn Val Asn Val Asn Glu Pro Thr Arg Pro Ser Arg Phe Phe Gly Lys 
            260                 265                 270         


Ala Val Thr Lys Glu Gln Leu Gln Ala Leu Gly Val Asn Ala Glu Asn 
        275                 280                 285             


Pro Pro Ala Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu 
    290                 295                 300                 


Lys Leu Ser Thr Asn Ser His Ser Thr Lys Val Lys Ala Ala Phe Asp 
305                 310                 315                 320 


Ala Ala Val Ser Gly Lys Ser Val Ser Gly Asp Val Glu Leu Thr Asn 
                325                 330                 335     


Ile Ile Lys Asn Ser Ser Phe Lys Ala Val Ile Tyr Gly Gly Ser Ala 
            340                 345                 350         


Lys Asp Glu Val Gln Ile Ile Asp Gly Asn Leu Gly Asp Leu Arg Asp 
        355                 360                 365             


Ile Leu Lys Lys Gly Ala Thr Phe Asn Arg Glu Thr Pro Gly Val Pro 
    370                 375                 380                 


Ile Ala Tyr Thr Thr Asn Phe Leu Lys Asp Asn Glu Leu Ala Val Ile 
385                 390                 395                 400 


Lys Asn Asn Ser Glu Tyr Ile Glu Thr Thr Ser Lys Ala Tyr Thr Asp 
                405                 410                 415     


Gly Lys Ile Asn Ile Asp His Ser Gly Gly Tyr Val Ala Gln Phe Asn 
            420                 425                 430         


Ile Ser Trp Asp Glu Val Asn Tyr Asp 
        435                 440     


<210>  3
<211>  416
<212>  PRT
<213>  Listeria monocytogenes

<400>  3

Met Lys Lys Ile Met Leu Val Phe Ile Thr Leu Ile Leu Val Ser Leu 
1               5                   10                  15      


Pro Ile Ala Gln Gln Thr Glu Ala Lys Asp Ala Ser Ala Phe Asn Lys 
            20                  25                  30          


Glu Asn Ser Ile Ser Ser Val Ala Pro Pro Ala Ser Pro Pro Ala Ser 
        35                  40                  45              


Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys Tyr 
    50                  55                  60                  


Ile Gln Gly Leu Asp Tyr Asn Lys Asn Asn Val Leu Val Tyr His Gly 
65                  70                  75                  80  


Asp Ala Val Thr Asn Val Pro Pro Arg Lys Gly Tyr Lys Asp Gly Asn 
                85                  90                  95      


Glu Tyr Ile Val Val Glu Lys Lys Lys Lys Ser Ile Asn Gln Asn Asn 
            100                 105                 110         


Ala Asp Ile Gln Val Val Asn Ala Ile Ser Ser Leu Thr Tyr Pro Gly 
        115                 120                 125             


Ala Leu Val Lys Ala Asn Ser Glu Leu Val Glu Asn Gln Pro Asp Val 
    130                 135                 140                 


Leu Pro Val Lys Arg Asp Ser Leu Thr Leu Ser Ile Asp Leu Pro Gly 
145                 150                 155                 160 


Met Thr Asn Gln Asp Asn Lys Ile Val Val Lys Asn Ala Thr Lys Ser 
                165                 170                 175     


Asn Val Asn Asn Ala Val Asn Thr Leu Val Glu Arg Trp Asn Glu Lys 
            180                 185                 190         


Tyr Ala Gln Ala Tyr Ser Asn Val Ser Ala Lys Ile Asp Tyr Asp Asp 
        195                 200                 205             


Glu Met Ala Tyr Ser Glu Ser Gln Leu Ile Ala Lys Phe Gly Thr Ala 
    210                 215                 220                 


Phe Lys Ala Val Asn Asn Ser Leu Asn Val Asn Phe Gly Ala Ile Ser 
225                 230                 235                 240 


Glu Gly Lys Met Gln Glu Glu Val Ile Ser Phe Lys Gln Ile Tyr Tyr 
                245                 250                 255     


Asn Val Asn Val Asn Glu Pro Thr Arg Pro Ser Arg Phe Phe Gly Lys 
            260                 265                 270         


Ala Val Thr Lys Glu Gln Leu Gln Ala Leu Gly Val Asn Ala Glu Asn 
        275                 280                 285             


Pro Pro Ala Tyr Ile Ser Ser Val Ala Tyr Gly Arg Gln Val Tyr Leu 
    290                 295                 300                 


Lys Leu Ser Thr Asn Ser His Ser Thr Lys Val Lys Ala Ala Phe Asp 
305                 310                 315                 320 


Ala Ala Val Ser Gly Lys Ser Val Ser Gly Asp Val Glu Leu Thr Asn 
                325                 330                 335     


Ile Ile Lys Asn Ser Ser Phe Lys Ala Val Ile Tyr Gly Gly Ser Ala 
            340                 345                 350         


Lys Asp Glu Val Gln Ile Ile Asp Gly Asn Leu Gly Asp Leu Arg Asp 
        355                 360                 365             


Ile Leu Lys Lys Gly Ala Thr Phe Asn Arg Glu Thr Pro Gly Val Pro 
    370                 375                 380                 


Ile Ala Tyr Thr Thr Asn Phe Leu Lys Asp Asn Glu Leu Ala Val Ile 
385                 390                 395                 400 


Lys Asn Asn Ser Glu Tyr Ile Glu Thr Thr Ser Lys Ala Tyr Thr Asp 
                405                 410                 415     


<210>  4
<211>  390
<212>  PRT
<213>  Listeria monocytogenes

<400>  4

Met Arg Ala Met Met Val Val Phe Ile Thr Ala Asn Cys Ile Thr Ile 
1               5                   10                  15      


Asn Pro Asp Ile Ile Phe Ala Ala Thr Asp Ser Glu Asp Ser Ser Leu 
            20                  25                  30          


Asn Thr Asp Glu Trp Glu Glu Glu Lys Thr Glu Glu Gln Pro Ser Glu 
        35                  40                  45              


Val Asn Thr Gly Pro Arg Tyr Glu Thr Ala Arg Glu Val Ser Ser Arg 
    50                  55                  60                  


Asp Ile Lys Glu Leu Glu Lys Ser Asn Lys Val Arg Asn Thr Asn Lys 
65                  70                  75                  80  


Ala Asp Leu Ile Ala Met Leu Lys Glu Lys Ala Glu Lys Gly Pro Asn 
                85                  90                  95      


Ile Asn Asn Asn Asn Ser Glu Gln Thr Glu Asn Ala Ala Ile Asn Glu 
            100                 105                 110         


Glu Ala Ser Gly Ala Asp Arg Pro Ala Ile Gln Val Glu Arg Arg His 
        115                 120                 125             


Pro Gly Leu Pro Ser Asp Ser Ala Ala Glu Ile Lys Lys Arg Arg Lys 
    130                 135                 140                 


Ala Ile Ala Ser Ser Asp Ser Glu Leu Glu Ser Leu Thr Tyr Pro Asp 
145                 150                 155                 160 


Lys Pro Thr Lys Val Asn Lys Lys Lys Val Ala Lys Glu Ser Val Ala 
                165                 170                 175     


Asp Ala Ser Glu Ser Asp Leu Asp Ser Ser Met Gln Ser Ala Asp Glu 
            180                 185                 190         


Ser Ser Pro Gln Pro Leu Lys Ala Asn Gln Gln Pro Phe Phe Pro Lys 
        195                 200                 205             


Val Phe Lys Lys Ile Lys Asp Ala Gly Lys Trp Val Arg Asp Lys Ile 
    210                 215                 220                 


Asp Glu Asn Pro Glu Val Lys Lys Ala Ile Val Asp Lys Ser Ala Gly 
225                 230                 235                 240 


Leu Ile Asp Gln Leu Leu Thr Lys Lys Lys Ser Glu Glu Val Asn Ala 
                245                 250                 255     


Ser Asp Phe Pro Pro Pro Pro Thr Asp Glu Glu Leu Arg Leu Ala Leu 
            260                 265                 270         


Pro Glu Thr Pro Met Leu Leu Gly Phe Asn Ala Pro Ala Thr Ser Glu 
        275                 280                 285             


Pro Ser Ser Phe Glu Phe Pro Pro Pro Pro Thr Asp Glu Glu Leu Arg 
    290                 295                 300                 


Leu Ala Leu Pro Glu Thr Pro Met Leu Leu Gly Phe Asn Ala Pro Ala 
305                 310                 315                 320 


Thr Ser Glu Pro Ser Ser Phe Glu Phe Pro Pro Pro Pro Thr Glu Asp 
                325                 330                 335     


Glu Leu Glu Ile Ile Arg Glu Thr Ala Ser Ser Leu Asp Ser Ser Phe 
            340                 345                 350         


Thr Arg Gly Asp Leu Ala Ser Leu Arg Asn Ala Ile Asn Arg His Ser 
        355                 360                 365             


Gln Asn Phe Ser Asp Phe Pro Pro Ile Pro Thr Glu Glu Glu Leu Asn 
    370                 375                 380                 


Gly Arg Gly Gly Arg Pro 
385                 390 


<210>  5
<211>  1170
<212>  DNA
<213>  Listeria monocytogenes

<400>  5
atgcgtgcga tgatggtggt tttcattact gccaattgca ttacgattaa ccccgacata       60

atatttgcag cgacagatag cgaagattct agtctaaaca cagatgaatg ggaagaagaa      120

aaaacagaag agcaaccaag cgaggtaaat acgggaccaa gatacgaaac tgcacgtgaa      180

gtaagttcac gtgatattaa agaactagaa aaatcgaata aagtgagaaa tacgaacaaa      240

gcagacctaa tagcaatgtt gaaagaaaaa gcagaaaaag gtccaaatat caataataac      300

aacagtgaac aaactgagaa tgcggctata aatgaagagg cttcaggagc cgaccgacca      360

gctatacaag tggagcgtcg tcatccagga ttgccatcgg atagcgcagc ggaaattaaa      420

aaaagaagga aagccatagc atcatcggat agtgagcttg aaagccttac ttatccggat      480

aaaccaacaa aagtaaataa gaaaaaagtg gcgaaagagt cagttgcgga tgcttctgaa      540

agtgacttag attctagcat gcagtcagca gatgagtctt caccacaacc tttaaaagca      600

aaccaacaac catttttccc taaagtattt aaaaaaataa aagatgcggg gaaatgggta      660

cgtgataaaa tcgacgaaaa tcctgaagta aagaaagcga ttgttgataa aagtgcaggg      720

ttaattgacc aattattaac caaaaagaaa agtgaagagg taaatgcttc ggacttcccg      780

ccaccaccta cggatgaaga gttaagactt gctttgccag agacaccaat gcttcttggt      840

tttaatgctc ctgctacatc agaaccgagc tcattcgaat ttccaccacc acctacggat      900

gaagagttaa gacttgcttt gccagagacg ccaatgcttc ttggttttaa tgctcctgct      960

acatcggaac cgagctcgtt cgaatttcca ccgcctccaa cagaagatga actagaaatc     1020

atccgggaaa cagcatcctc gctagattct agttttacaa gaggggattt agctagtttg     1080

agaaatgcta ttaatcgcca tagtcaaaat ttctctgatt tcccaccaat cccaacagaa     1140

gaagagttga acgggagagg cggtagacca                                      1170


<210>  6
<211>  32
<212>  PRT
<213>  Listeria monocytogenes

<400>  6

Lys Glu Asn Ser Ile Ser Ser Met Ala Pro Pro Ala Ser Pro Pro Ala 
1               5                   10                  15      


Ser Pro Lys Thr Pro Ile Glu Lys Lys His Ala Asp Glu Ile Asp Lys 
            20                  25                  30          


<210>  7
<211>  19
<212>  PRT
<213>  Listeria monocytogenes

<400>  7

Lys Glu Asn Ser Ile Ser Ser Met Ala Pro Pro Ala Ser Pro Pro Ala 
1               5                   10                  15      


Ser Pro Lys 
            


<210>  8
<211>  14
<212>  PRT
<213>  Listeria monocytogenes

<400>  8

Lys Thr Glu Glu Gln Pro Ser Glu Val Asn Thr Gly Pro Arg 
1               5                   10                  


<210>  9
<211>  28
<212>  PRT
<213>  Listeria monocytogenes

<400>  9

Lys Ala Ser Val Thr Asp Thr Ser Glu Gly Asp Leu Asp Ser Ser Met 
1               5                   10                  15      


Gln Ser Ala Asp Glu Ser Thr Pro Gln Pro Leu Lys 
            20                  25              


<210>  10
<211>  20
<212>  PRT
<213>  Listeria monocytogenes

<400>  10

Lys Asn Glu Glu Val Asn Ala Ser Asp Phe Pro Pro Pro Pro Thr Asp 
1               5                   10                  15      


Glu Glu Leu Arg 
            20  


<210>  11
<211>  33
<212>  PRT
<213>  Listeria monocytogenes

<400>  11

Arg Gly Gly Ile Pro Thr Ser Glu Glu Phe Ser Ser Leu Asn Ser Gly 
1               5                   10                  15      


Asp Phe Thr Asp Asp Glu Asn Ser Glu Thr Thr Glu Glu Glu Ile Asp 
            20                  25                  30          


Arg 
    


<210>  12
<211>  19
<212>  PRT
<213>  Listeria seeligeri

<400>  12

Arg Ser Glu Val Thr Ile Ser Pro Ala Glu Thr Pro Glu Ser Pro Pro 
1               5                   10                  15      


Ala Thr Pro 
            


<210>  13
<211>  17
<212>  PRT
<213>  Streptococcus pyogenes

<400>  13

Lys Gln Asn Thr Ala Ser Thr Glu Thr Thr Thr Thr Asn Glu Gln Pro 
1               5                   10                  15      


Lys 
    


<210>  14
<211>  17
<212>  PRT
<213>  Streptococcus equisimilis

<400>  14

Lys Gln Asn Thr Ala Asn Thr Glu Thr Thr Thr Thr Asn Glu Gln Pro 
1               5                   10                  15      


Lys 
    


<210>  15
<211>  2322
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Gln Ser Gly Arg Gly Pro Pro Leu Pro Ala Pro Gly Leu Ala Leu 
1               5                   10                  15      


Ala Leu Thr Leu Thr Met Leu Ala Arg Leu Ala Ser Ala Ala Ser Phe 
            20                  25                  30          


Phe Gly Glu Asn His Leu Glu Val Pro Val Ala Thr Ala Leu Thr Asp 
        35                  40                  45              


Ile Asp Leu Gln Leu Gln Phe Ser Thr Ser Gln Pro Glu Ala Leu Leu 
    50                  55                  60                  


Leu Leu Ala Ala Gly Pro Ala Asp His Leu Leu Leu Gln Leu Tyr Ser 
65                  70                  75                  80  


Gly Arg Leu Gln Val Arg Leu Val Leu Gly Gln Glu Glu Leu Arg Leu 
                85                  90                  95      


Gln Thr Pro Ala Glu Thr Leu Leu Ser Asp Ser Ile Pro His Thr Val 
            100                 105                 110         


Val Leu Thr Val Val Glu Gly Trp Ala Thr Leu Ser Val Asp Gly Phe 
        115                 120                 125             


Leu Asn Ala Ser Ser Ala Val Pro Gly Ala Pro Leu Glu Val Pro Tyr 
    130                 135                 140                 


Gly Leu Phe Val Gly Gly Thr Gly Thr Leu Gly Leu Pro Tyr Leu Arg 
145                 150                 155                 160 


Gly Thr Ser Arg Pro Leu Arg Gly Cys Leu His Ala Ala Thr Leu Asn 
                165                 170                 175     


Gly Arg Ser Leu Leu Arg Pro Leu Thr Pro Asp Val His Glu Gly Cys 
            180                 185                 190         


Ala Glu Glu Phe Ser Ala Ser Asp Asp Val Ala Leu Gly Phe Ser Gly 
        195                 200                 205             


Pro His Ser Leu Ala Ala Phe Pro Ala Trp Gly Thr Gln Asp Glu Gly 
    210                 215                 220                 


Thr Leu Glu Phe Thr Leu Thr Thr Gln Ser Arg Gln Ala Pro Leu Ala 
225                 230                 235                 240 


Phe Gln Ala Gly Gly Arg Arg Gly Asp Phe Ile Tyr Val Asp Ile Phe 
                245                 250                 255     


Glu Gly His Leu Arg Ala Val Val Glu Lys Gly Gln Gly Thr Val Leu 
            260                 265                 270         


Leu His Asn Ser Val Pro Val Ala Asp Gly Gln Pro His Glu Val Ser 
        275                 280                 285             


Val His Ile Asn Ala His Arg Leu Glu Ile Ser Val Asp Gln Tyr Pro 
    290                 295                 300                 


Thr His Thr Ser Asn Arg Gly Val Leu Ser Tyr Leu Glu Pro Arg Gly 
305                 310                 315                 320 


Ser Leu Leu Leu Gly Gly Leu Asp Ala Glu Ala Ser Arg His Leu Gln 
                325                 330                 335     


Glu His Arg Leu Gly Leu Thr Pro Glu Ala Thr Asn Ala Ser Leu Leu 
            340                 345                 350         


Gly Cys Met Glu Asp Leu Ser Val Asn Gly Gln Arg Arg Gly Leu Arg 
        355                 360                 365             


Glu Ala Leu Leu Thr Arg Asn Met Ala Ala Gly Cys Arg Leu Glu Glu 
    370                 375                 380                 


Glu Glu Tyr Glu Asp Asp Ala Tyr Gly His Tyr Glu Ala Phe Ser Thr 
385                 390                 395                 400 


Leu Ala Pro Glu Ala Trp Pro Ala Met Glu Leu Pro Glu Pro Cys Val 
                405                 410                 415     


Pro Glu Pro Gly Leu Pro Pro Val Phe Ala Asn Phe Thr Gln Leu Leu 
            420                 425                 430         


Thr Ile Ser Pro Leu Val Val Ala Glu Gly Gly Thr Ala Trp Leu Glu 
        435                 440                 445             


Trp Arg His Val Gln Pro Thr Leu Asp Leu Met Glu Ala Glu Leu Arg 
    450                 455                 460                 


Lys Ser Gln Val Leu Phe Ser Val Thr Arg Gly Ala Arg His Gly Glu 
465                 470                 475                 480 


Leu Glu Leu Asp Ile Pro Gly Ala Gln Ala Arg Lys Met Phe Thr Leu 
                485                 490                 495     


Leu Asp Val Val Asn Arg Lys Ala Arg Phe Ile His Asp Gly Ser Glu 
            500                 505                 510         


Asp Thr Ser Asp Gln Leu Val Leu Glu Val Ser Val Thr Ala Arg Val 
        515                 520                 525             


Pro Met Pro Ser Cys Leu Arg Arg Gly Gln Thr Tyr Leu Leu Pro Ile 
    530                 535                 540                 


Gln Val Asn Pro Val Asn Asp Pro Pro His Ile Ile Phe Pro His Gly 
545                 550                 555                 560 


Ser Leu Met Val Ile Leu Glu His Thr Gln Lys Pro Leu Gly Pro Glu 
                565                 570                 575     


Val Phe Gln Ala Tyr Asp Pro Asp Ser Ala Cys Glu Gly Leu Thr Phe 
            580                 585                 590         


Gln Val Leu Gly Thr Ser Ser Gly Leu Pro Val Glu Arg Arg Asp Gln 
        595                 600                 605             


Pro Gly Glu Pro Ala Thr Glu Phe Ser Cys Arg Glu Leu Glu Ala Gly 
    610                 615                 620                 


Ser Leu Val Tyr Val His Arg Gly Gly Pro Ala Gln Asp Leu Thr Phe 
625                 630                 635                 640 


Arg Val Ser Asp Gly Leu Gln Ala Ser Pro Pro Ala Thr Leu Lys Val 
                645                 650                 655     


Val Ala Ile Arg Pro Ala Ile Gln Ile His Arg Ser Thr Gly Leu Arg 
            660                 665                 670         


Leu Ala Gln Gly Ser Ala Met Pro Ile Leu Pro Ala Asn Leu Ser Val 
        675                 680                 685             


Glu Thr Asn Ala Val Gly Gln Asp Val Ser Val Leu Phe Arg Val Thr 
    690                 695                 700                 


Gly Ala Leu Gln Phe Gly Glu Leu Gln Lys Gln Gly Ala Gly Gly Val 
705                 710                 715                 720 


Glu Gly Ala Glu Trp Trp Ala Thr Gln Ala Phe His Gln Arg Asp Val 
                725                 730                 735     


Glu Gln Gly Arg Val Arg Tyr Leu Ser Thr Asp Pro Gln His His Ala 
            740                 745                 750         


Tyr Asp Thr Val Glu Asn Leu Ala Leu Glu Val Gln Val Gly Gln Glu 
        755                 760                 765             


Ile Leu Ser Asn Leu Ser Phe Pro Val Thr Ile Gln Arg Ala Thr Val 
    770                 775                 780                 


Trp Met Leu Arg Leu Glu Pro Leu His Thr Gln Asn Thr Gln Gln Glu 
785                 790                 795                 800 


Thr Leu Thr Thr Ala His Leu Glu Ala Thr Leu Glu Glu Ala Gly Pro 
                805                 810                 815     


Ser Pro Pro Thr Phe His Tyr Glu Val Val Gln Ala Pro Arg Lys Gly 
            820                 825                 830         


Asn Leu Gln Leu Gln Gly Thr Arg Leu Ser Asp Gly Gln Gly Phe Thr 
        835                 840                 845             


Gln Asp Asp Ile Gln Ala Gly Arg Val Thr Tyr Gly Ala Thr Ala Arg 
    850                 855                 860                 


Ala Ser Glu Ala Val Glu Asp Thr Phe Arg Phe Arg Val Thr Ala Pro 
865                 870                 875                 880 


Pro Tyr Phe Ser Pro Leu Tyr Thr Phe Pro Ile His Ile Gly Gly Asp 
                885                 890                 895     


Pro Asp Ala Pro Val Leu Thr Asn Val Leu Leu Val Val Pro Glu Gly 
            900                 905                 910         


Gly Glu Gly Val Leu Ser Ala Asp His Leu Phe Val Lys Ser Leu Asn 
        915                 920                 925             


Ser Ala Ser Tyr Leu Tyr Glu Val Met Glu Arg Pro Arg His Gly Arg 
    930                 935                 940                 


Leu Ala Trp Arg Gly Thr Gln Asp Lys Thr Thr Met Val Thr Ser Phe 
945                 950                 955                 960 


Thr Asn Glu Asp Leu Leu Arg Gly Arg Leu Val Tyr Gln His Asp Asp 
                965                 970                 975     


Ser Glu Thr Thr Glu Asp Asp Ile Pro Phe Val Ala Thr Arg Gln Gly 
            980                 985                 990         


Glu Ser Ser Gly Asp Met Ala Trp  Glu Glu Val Arg Gly  Val Phe Arg 
        995                 1000                 1005             


Val Ala  Ile Gln Pro Val Asn  Asp His Ala Pro Val  Gln Thr Ile 
    1010                 1015                 1020             


Ser Arg  Ile Phe His Val Ala  Arg Gly Gly Arg Arg  Leu Leu Thr 
    1025                 1030                 1035             


Thr Asp  Asp Val Ala Phe Ser  Asp Ala Asp Ser Gly  Phe Ala Asp 
    1040                 1045                 1050             


Ala Gln  Leu Val Leu Thr Arg  Lys Asp Leu Leu Phe  Gly Ser Ile 
    1055                 1060                 1065             


Val Ala  Val Asp Glu Pro Thr  Arg Pro Ile Tyr Arg  Phe Thr Gln 
    1070                 1075                 1080             


Glu Asp  Leu Arg Lys Arg Arg  Val Leu Phe Val His  Ser Gly Ala 
    1085                 1090                 1095             


Asp Arg  Gly Trp Ile Gln Leu  Gln Val Ser Asp Gly  Gln His Gln 
    1100                 1105                 1110             


Ala Thr  Ala Leu Leu Glu Val  Gln Ala Ser Glu Pro  Tyr Leu Arg 
    1115                 1120                 1125             


Val Ala  Asn Gly Ser Ser Leu  Val Val Pro Gln Gly  Gly Gln Gly 
    1130                 1135                 1140             


Thr Ile  Asp Thr Ala Val Leu  His Leu Asp Thr Asn  Leu Asp Ile 
    1145                 1150                 1155             


Arg Ser  Gly Asp Glu Val His  Tyr His Val Thr Ala  Gly Pro Arg 
    1160                 1165                 1170             


Trp Gly  Gln Leu Val Arg Ala  Gly Gln Pro Ala Thr  Ala Phe Ser 
    1175                 1180                 1185             


Gln Gln  Asp Leu Leu Asp Gly  Ala Val Leu Tyr Ser  His Asn Gly 
    1190                 1195                 1200             


Ser Leu  Ser Pro Arg Asp Thr  Met Ala Phe Ser Val  Glu Ala Gly 
    1205                 1210                 1215             


Pro Val  His Thr Asp Ala Thr  Leu Gln Val Thr Ile  Ala Leu Glu 
    1220                 1225                 1230             


Gly Pro  Leu Ala Pro Leu Lys  Leu Val Arg His Lys  Lys Ile Tyr 
    1235                 1240                 1245             


Val Phe  Gln Gly Glu Ala Ala  Glu Ile Arg Arg Asp  Gln Leu Glu 
    1250                 1255                 1260             


Ala Ala  Gln Glu Ala Val Pro  Pro Ala Asp Ile Val  Phe Ser Val 
    1265                 1270                 1275             


Lys Ser  Pro Pro Ser Ala Gly  Tyr Leu Val Met Val  Ser Arg Gly 
    1280                 1285                 1290             


Ala Leu  Ala Asp Glu Pro Pro  Ser Leu Asp Pro Val  Gln Ser Phe 
    1295                 1300                 1305             


Ser Gln  Glu Ala Val Asp Thr  Gly Arg Val Leu Tyr  Leu His Ser 
    1310                 1315                 1320             


Arg Pro  Glu Ala Trp Ser Asp  Ala Phe Ser Leu Asp  Val Ala Ser 
    1325                 1330                 1335             


Gly Leu  Gly Ala Pro Leu Glu  Gly Val Leu Val Glu  Leu Glu Val 
    1340                 1345                 1350             


Leu Pro  Ala Ala Ile Pro Leu  Glu Ala Gln Asn Phe  Ser Val Pro 
    1355                 1360                 1365             


Glu Gly  Gly Ser Leu Thr Leu  Ala Pro Pro Leu Leu  Arg Val Ser 
    1370                 1375                 1380             


Gly Pro  Tyr Phe Pro Thr Leu  Leu Gly Leu Ser Leu  Gln Val Leu 
    1385                 1390                 1395             


Glu Pro  Pro Gln His Gly Ala  Leu Gln Lys Glu Asp  Gly Pro Gln 
    1400                 1405                 1410             


Ala Arg  Thr Leu Ser Ala Phe  Ser Trp Arg Met Val  Glu Glu Gln 
    1415                 1420                 1425             


Leu Ile  Arg Tyr Val His Asp  Gly Ser Glu Thr Leu  Thr Asp Ser 
    1430                 1435                 1440             


Phe Val  Leu Met Ala Asn Ala  Ser Glu Met Asp Arg  Gln Ser His 
    1445                 1450                 1455             


Pro Val  Ala Phe Thr Val Thr  Val Leu Pro Val Asn  Asp Gln Pro 
    1460                 1465                 1470             


Pro Ile  Leu Thr Thr Asn Thr  Gly Leu Gln Met Trp  Glu Gly Ala 
    1475                 1480                 1485             


Thr Ala  Pro Ile Pro Ala Glu  Ala Leu Arg Ser Thr  Asp Gly Asp 
    1490                 1495                 1500             


Ser Gly  Ser Glu Asp Leu Val  Tyr Thr Ile Glu Gln  Pro Ser Asn 
    1505                 1510                 1515             


Gly Arg  Val Val Leu Arg Gly  Ala Pro Gly Thr Glu  Val Arg Ser 
    1520                 1525                 1530             


Phe Thr  Gln Ala Gln Leu Asp  Gly Gly Leu Val Leu  Phe Ser His 
    1535                 1540                 1545             


Arg Gly  Thr Leu Asp Gly Gly  Phe Arg Phe Arg Leu  Ser Asp Gly 
    1550                 1555                 1560             


Glu His  Thr Ser Pro Gly His  Phe Phe Arg Val Thr  Ala Gln Lys 
    1565                 1570                 1575             


Gln Val  Leu Leu Ser Leu Lys  Gly Ser Gln Thr Leu  Thr Val Cys 
    1580                 1585                 1590             


Pro Gly  Ser Val Gln Pro Leu  Ser Ser Gln Thr Leu  Arg Ala Ser 
    1595                 1600                 1605             


Ser Ser  Ala Gly Thr Asp Pro  Gln Leu Leu Leu Tyr  Arg Val Val 
    1610                 1615                 1620             


Arg Gly  Pro Gln Leu Gly Arg  Leu Phe His Ala Gln  Gln Asp Ser 
    1625                 1630                 1635             


Thr Gly  Glu Ala Leu Val Asn  Phe Thr Gln Ala Glu  Val Tyr Ala 
    1640                 1645                 1650             


Gly Asn  Ile Leu Tyr Glu His  Glu Met Pro Pro Glu  Pro Phe Trp 
    1655                 1660                 1665             


Glu Ala  His Asp Thr Leu Glu  Leu Gln Leu Ser Ser  Pro Pro Ala 
    1670                 1675                 1680             


Arg Asp  Val Ala Ala Thr Leu  Ala Val Ala Val Ser  Phe Glu Ala 
    1685                 1690                 1695             


Ala Cys  Pro Gln Arg Pro Ser  His Leu Trp Lys Asn  Lys Gly Leu 
    1700                 1705                 1710             


Trp Val  Pro Glu Gly Gln Arg  Ala Arg Ile Thr Val  Ala Ala Leu 
    1715                 1720                 1725             


Asp Ala  Ser Asn Leu Leu Ala  Ser Val Pro Ser Pro  Gln Arg Ser 
    1730                 1735                 1740             


Glu His  Asp Val Leu Phe Gln  Val Thr Gln Phe Pro  Ser Arg Gly 
    1745                 1750                 1755             


Gln Leu  Leu Val Ser Glu Glu  Pro Leu His Ala Gly  Gln Pro His 
    1760                 1765                 1770             


Phe Leu  Gln Ser Gln Leu Ala  Ala Gly Gln Leu Val  Tyr Ala His 
    1775                 1780                 1785             


Gly Gly  Gly Gly Thr Gln Gln  Asp Gly Phe His Phe  Arg Ala His 
    1790                 1795                 1800             


Leu Gln  Gly Pro Ala Gly Ala  Ser Val Ala Gly Pro  Gln Thr Ser 
    1805                 1810                 1815             


Glu Ala  Phe Ala Ile Thr Val  Arg Asp Val Asn Glu  Arg Pro Pro 
    1820                 1825                 1830             


Gln Pro  Gln Ala Ser Val Pro  Leu Arg Leu Thr Arg  Gly Ser Arg 
    1835                 1840                 1845             


Ala Pro  Ile Ser Arg Ala Gln  Leu Ser Val Val Asp  Pro Asp Ser 
    1850                 1855                 1860             


Ala Pro  Gly Glu Ile Glu Tyr  Glu Val Gln Arg Ala  Pro His Asn 
    1865                 1870                 1875             


Gly Phe  Leu Ser Leu Val Gly  Gly Gly Leu Gly Pro  Val Thr Arg 
    1880                 1885                 1890             


Phe Thr  Gln Ala Asp Val Asp  Ser Gly Arg Leu Ala  Phe Val Ala 
    1895                 1900                 1905             


Asn Gly  Ser Ser Val Ala Gly  Ile Phe Gln Leu Ser  Met Ser Asp 
    1910                 1915                 1920             


Gly Ala  Ser Pro Pro Leu Pro  Met Ser Leu Ala Val  Asp Ile Leu 
    1925                 1930                 1935             


Pro Ser  Ala Ile Glu Val Gln  Leu Arg Ala Pro Leu  Glu Val Pro 
    1940                 1945                 1950             


Gln Ala  Leu Gly Arg Ser Ser  Leu Ser Gln Gln Gln  Leu Arg Val 
    1955                 1960                 1965             


Val Ser  Asp Arg Glu Glu Pro  Glu Ala Ala Tyr Arg  Leu Ile Gln 
    1970                 1975                 1980             


Gly Pro  Gln Tyr Gly His Leu  Leu Val Gly Gly Arg  Pro Thr Ser 
    1985                 1990                 1995             


Ala Phe  Ser Gln Phe Gln Ile  Asp Gln Gly Glu Val  Val Phe Ala 
    2000                 2005                 2010             


Phe Thr  Asn Phe Ser Ser Ser  His Asp His Phe Arg  Val Leu Ala 
    2015                 2020                 2025             


Leu Ala  Arg Gly Val Asn Ala  Ser Ala Val Val Asn  Val Thr Val 
    2030                 2035                 2040             


Arg Ala  Leu Leu His Val Trp  Ala Gly Gly Pro Trp  Pro Gln Gly 
    2045                 2050                 2055             


Ala Thr  Leu Arg Leu Asp Pro  Thr Val Leu Asp Ala  Gly Glu Leu 
    2060                 2065                 2070             


Ala Asn  Arg Thr Gly Ser Val  Pro Arg Phe Arg Leu  Leu Glu Gly 
    2075                 2080                 2085             


Pro Arg  His Gly Arg Val Val  Arg Val Pro Arg Ala  Arg Thr Glu 
    2090                 2095                 2100             


Pro Gly  Gly Ser Gln Leu Val  Glu Gln Phe Thr Gln  Gln Asp Leu 
    2105                 2110                 2115             


Glu Asp  Gly Arg Leu Gly Leu  Glu Val Gly Arg Pro  Glu Gly Arg 
    2120                 2125                 2130             


Ala Pro  Gly Pro Ala Gly Asp  Ser Leu Thr Leu Glu  Leu Trp Ala 
    2135                 2140                 2145             


Gln Gly  Val Pro Pro Ala Val  Ala Ser Leu Asp Phe  Ala Thr Glu 
    2150                 2155                 2160             


Pro Tyr  Asn Ala Ala Arg Pro  Tyr Ser Val Ala Leu  Leu Ser Val 
    2165                 2170                 2175             


Pro Glu  Ala Ala Arg Thr Glu  Ala Gly Lys Pro Glu  Ser Ser Thr 
    2180                 2185                 2190             


Pro Thr  Gly Glu Pro Gly Pro  Met Ala Ser Ser Pro  Glu Pro Ala 
    2195                 2200                 2205             


Val Ala  Lys Gly Gly Phe Leu  Ser Phe Leu Glu Ala  Asn Met Phe 
    2210                 2215                 2220             


Ser Val  Ile Ile Pro Met Cys  Leu Val Leu Leu Leu  Leu Ala Leu 
    2225                 2230                 2235             


Ile Leu  Pro Leu Leu Phe Tyr  Leu Arg Lys Arg Asn  Lys Thr Gly 
    2240                 2245                 2250             


Lys His  Asp Val Gln Val Leu  Thr Ala Lys Pro Arg  Asn Gly Leu 
    2255                 2260                 2265             


Ala Gly  Asp Thr Glu Thr Phe  Arg Lys Val Glu Pro  Gly Gln Ala 
    2270                 2275                 2280             


Ile Pro  Leu Thr Ala Val Pro  Gly Gln Gly Pro Pro  Pro Gly Gly 
    2285                 2290                 2295             


Gln Pro  Asp Pro Glu Leu Leu  Gln Phe Cys Arg Thr  Pro Asn Pro 
    2300                 2305                 2310             


Ala Leu  Lys Asn Gly Gln Tyr  Trp Val 
    2315                 2320         


<210>  16
<211>  7011
<212>  DNA
<213>  Homo sapiens

<400>  16
atgcagtccg gccgcggccc cccacttcca gcccccggcc tggccttggc tttgaccctg       60

actatgttgg ccagacttgc atccgcggct tccttcttcg gtgagaacca cctggaggtg      120

cctgtggcca cggctctgac cgacatagac ctgcagctgc agttctccac gtcccagccc      180

gaagccctcc ttctcctggc agcaggccca gctgaccacc tcctgctgca gctctactct      240

ggacgcctgc aggtcagact tgttctgggc caggaggagc tgaggctgca gactccagca      300

gagacgctgc tgagtgactc catcccccac actgtggtgc tgactgtcgt agagggctgg      360

gccacgttgt cagtcgatgg gtttctgaac gcctcctcag cagtcccagg agccccccta      420

gaggtcccct atgggctctt tgttgggggc actgggaccc ttggcctgcc ctacctgagg      480

ggaaccagcc gacccctgag gggttgcctc catgcagcca ccctcaatgg ccgcagcctc      540

ctccggcctc tgacccccga tgtgcatgag ggctgtgctg aagagttttc tgccagtgat      600

gatgtggccc tgggcttctc tgggccccac tctctggctg ccttccctgc ctggggcact      660

caggacgaag gaaccctaga gtttacactc accacacaga gccggcaggc acccttggcc      720

ttccaggcag ggggccggcg tggggacttc atctatgtgg acatatttga gggccacctg      780

cgggccgtgg tggagaaggg ccagggtacc gtattgctcc acaacagtgt gcctgtggcc      840

gatgggcagc cccatgaggt cagtgtccac atcaatgctc accggctgga aatctccgtg      900

gaccagtacc ctacgcatac ttcgaaccga ggagtcctca gctacctgga gccacggggc      960

agtctccttc tcggggggct ggatgcagag gcctctcgtc acctccagga acaccgcctg     1020

ggcctgacac cagaggccac caatgcctcc ctgctgggct gcatggaaga cctcagtgtc     1080

aatggccaga ggcgggggct gcgggaagct ttgctgacgc gcaacatggc agccggctgc     1140

aggctggagg aggaggagta tgaggacgat gcctatggac attatgaagc tttctccacc     1200

ctggcccctg aggcttggcc agccatggag ctgcctgagc catgcgtgcc tgagccaggg     1260

ctgcctcctg tctttgccaa tttcacccag ctgctgacta tcagcccact ggtggtggcc     1320

gaggggggca cagcctggct tgagtggagg catgtgcagc ccacgctgga cctgatggag     1380

gctgagctgc gcaaatccca ggtgctgttc agcgtgaccc gaggggcacg ccatggcgag     1440

ctcgagctgg acatcccggg agcccaggca cgaaaaatgt tcaccctcct ggacgtggtg     1500

aaccgcaagg cccgcttcat ccacgatggc tctgaggaca cctccgacca gctggtgctg     1560

gaggtgtcgg tgacggctcg ggtgcccatg ccctcatgcc ttcggagggg ccaaacatac     1620

ctcctgccca tccaggtcaa ccctgtcaat gacccacccc acatcatctt cccacatggc     1680

agcctcatgg tgatcctgga acacacgcag aagccgctgg ggcctgaggt tttccaggcc     1740

tatgacccgg actctgcctg tgagggcctc accttccagg tccttggcac ctcctctggc     1800

ctccccgtgg agcgccgaga ccagcctggg gagccggcga ccgagttctc ctgccgggag     1860

ttggaggccg gcagcctagt ctatgtccac cgcggtggtc ctgcacagga cttgacgttc     1920

cgggtcagcg atggactgca ggccagcccc ccggccacgc tgaaggtggt ggccatccgg     1980

ccggccatac agatccaccg cagcacaggg ttgcgactgg cccaaggctc tgccatgccc     2040

atcttgcccg ccaacctgtc ggtggagacc aatgccgtgg ggcaggatgt gagcgtgctg     2100

ttccgcgtca ctggggccct gcagtttggg gagctgcaga agcagggggc aggtggggtg     2160

gagggtgctg agtggtgggc cacacaggcg ttccaccagc gggatgtgga gcagggccgc     2220

gtgaggtacc tgagcactga cccacagcac cacgcttacg acaccgtgga gaacctggcc     2280

ctggaggtgc aggtgggcca ggagatcctg agcaatctgt ccttcccagt gaccatccag     2340

agagccactg tgtggatgct gcggctggag ccactgcaca ctcagaacac ccagcaggag     2400

accctcacca cagcccacct ggaggccacc ctggaggagg caggcccaag ccccccaacc     2460

ttccattatg aggtggttca ggctcccagg aaaggcaacc ttcaactaca gggcacaagg     2520

ctgtcagatg gccagggctt cacccaggat gacatacagg ctggccgggt gacctatggg     2580

gccacagcac gtgcctcaga ggcagtcgag gacaccttcc gtttccgtgt cacagctcca     2640

ccatatttct ccccactcta taccttcccc atccacattg gtggtgaccc agatgcgcct     2700

gtcctcacca atgtcctcct cgtggtgcct gagggtggtg agggtgtcct ctctgctgac     2760

cacctctttg tcaagagtct caacagtgcc agctacctct atgaggtcat ggagcggccc     2820

cgccatggga ggttggcttg gcgtgggaca caggacaaga ccactatggt gacatccttc     2880

accaatgaag acctgttgcg tggccggctg gtctaccagc atgatgactc cgagaccaca     2940

gaagatgata tcccatttgt tgctacccgc cagggcgaga gcagtggtga catggcctgg     3000

gaggaggtac ggggtgtctt ccgagtggcc atccagcccg tgaatgacca cgcccctgtg     3060

cagaccatca gccggatctt ccatgtggcc cggggtgggc ggcggctgct gactacagac     3120

gacgtggcct tcagcgatgc tgactcgggc tttgctgacg cccagctggt gcttacccgc     3180

aaggacctcc tctttggcag tatcgtggcc gtagatgagc ccacgcggcc catctaccgc     3240

ttcacccagg aggacctcag gaagaggcga gtactgttcg tgcactcagg ggctgaccgt     3300

ggctggatcc agctgcaggt gtccgacggg caacaccagg ccactgcgct gctggaggtg     3360

caggcctcgg aaccctacct ccgtgtggcc aacggctcca gccttgtggt ccctcaaggg     3420

ggccagggca ccatcgacac ggccgtgctc cacctggaca ccaacctcga catccgcagt     3480

ggggatgagg tccactacca cgtcacagct ggccctcgct ggggacagct agtccgggct     3540

ggtcagccag ccacagcctt ctcccagcag gacctgctgg atggggccgt tctctatagc     3600

cacaatggca gcctcagccc ccgcgacacc atggccttct ccgtggaagc agggccagtg     3660

cacacggatg ccaccctaca agtgaccatt gccctagagg gcccactggc cccactgaag     3720

ctggtccggc acaagaagat ctacgtcttc cagggagagg cagctgagat cagaagggac     3780

cagctggagg cagcccagga ggcagtgcca cctgcagaca tcgtattctc agtgaagagc     3840

ccaccgagtg ccggctacct ggtgatggtg tcgcgtggcg ccttggcaga tgagccaccc     3900

agcctggacc ctgtgcagag cttctcccag gaggcagtgg acacaggcag ggtcctgtac     3960

ctgcactccc gccctgaggc ctggagcgat gccttctcgc tggatgtggc ctcaggcctg     4020

ggtgctcccc tcgagggcgt ccttgtggag ctggaggtgc tgcccgctgc catcccacta     4080

gaggcgcaaa acttcagcgt ccctgagggt ggcagcctca ccctggcccc tccactgctc     4140

cgtgtctccg ggccctactt ccccactctc ctgggcctca gcctgcaggt gctggagcca     4200

ccccagcatg gagccctgca gaaggaggac ggacctcaag ccaggaccct cagcgccttc     4260

tcctggagaa tggtggaaga gcagctgatc cgctacgtgc atgacgggag cgagacactg     4320

acagacagtt ttgtcctgat ggctaatgcc tccgagatgg atcgccagag ccatcctgtg     4380

gccttcactg tcactgtcct gcctgtcaat gaccaacccc ccatcctcac tacaaacaca     4440

ggcctgcaga tgtgggaggg ggccactgcg cccatccctg cggaggctct gaggagcacg     4500

gacggcgact ctgggtctga ggatctggtc tacaccatcg agcagcccag caacgggcgg     4560

gtagtgctgc ggggggcgcc gggcactgag gtgcgcagct tcacgcaggc ccagctggac     4620

ggcgggctcg tgctgttctc acacagagga accctggatg gaggcttccg cttccgcctc     4680

tctgacggcg agcacacttc ccccggacac ttcttccgag tgacggccca gaagcaagtg     4740

ctcctctcgc tgaagggcag ccagacactg actgtctgcc cagggtccgt ccagccactc     4800

agcagtcaga ccctcagggc cagctccagc gcaggcactg acccccagct cctgctctac     4860

cgtgtggtgc ggggccccca gctaggccgg ctgttccacg cccagcagga cagcacaggg     4920

gaggccctgg tgaacttcac tcaggcagag gtctacgctg ggaatattct gtatgagcat     4980

gagatgcccc ccgagccctt ttgggaggcc catgataccc tagagctcca gctgtcctcg     5040

ccgcctgccc gggacgtggc cgccaccctt gctgtggctg tgtcttttga ggctgcctgt     5100

ccccagcgcc ccagccacct ctggaagaac aaaggtctct gggtccccga gggccagcgg     5160

gccaggatca ccgtggctgc tctggatgcc tccaatctct tggccagcgt tccatcaccc     5220

cagcgctcag agcatgatgt gctcttccag gtcacacagt tccccagccg gggccagctg     5280

ttggtgtccg aggagcccct ccatgctggg cagccccact tcctgcagtc ccagctggct     5340

gcagggcagc tagtgtatgc ccacggcggt gggggcaccc agcaggatgg cttccacttt     5400

cgtgcccacc tccaggggcc agcaggggcc tccgtggctg gaccccaaac ctcagaggcc     5460

tttgccatca cggtgaggga tgtaaatgag cggccccctc agccacaggc ctctgtccca     5520

ctccggctca cccgaggctc tcgtgccccc atctcccggg cccagctgag tgtggtggac     5580

ccagactcag ctcctgggga gattgagtac gaggtccagc gggcacccca caacggcttc     5640

ctcagcctgg tgggtggtgg cctggggccc gtgacccgct tcacgcaagc cgatgtggat     5700

tcagggcggc tggccttcgt ggccaacggg agcagcgtgg caggcatctt ccagctgagc     5760

atgtctgatg gggccagccc acccctgccc atgtccctgg ctgtggacat cctaccatcc     5820

gccatcgagg tgcagctgcg ggcacccctg gaggtgcccc aagctttggg gcgctcctca     5880

ctgagccagc agcagctccg ggtggtttca gatcgggagg agccagaggc agcataccgc     5940

ctcatccagg gaccccagta tgggcatctc ctggtgggcg ggcggcccac ctcggccttc     6000

agccaattcc agatagacca gggcgaggtg gtctttgcct tcaccaactt ctcctcctct     6060

catgaccact tcagagtcct ggcactggct aggggtgtca atgcatcagc cgtagtgaac     6120

gtcactgtga gggctctgct gcatgtgtgg gcaggtgggc catggcccca gggtgccacc     6180

ctgcgcctgg accccaccgt cctagatgct ggcgagctgg ccaaccgcac aggcagtgtg     6240

ccgcgcttcc gcctcctgga gggaccccgg catggccgcg tggtccgcgt gccccgagcc     6300

aggacggagc ccgggggcag ccagctggtg gagcagttca ctcagcagga ccttgaggac     6360

gggaggctgg ggctggaggt gggcaggcca gaggggaggg cccccggccc cgcaggtgac     6420

agtctcactc tggagctgtg ggcacagggc gtcccgcctg ctgtggcctc cctggacttt     6480

gccactgagc cttacaatgc tgcccggccc tacagcgtgg ccctgctcag tgtccccgag     6540

gccgcccgga cggaagcagg gaagccagag agcagcaccc ccacaggcga gccaggcccc     6600

atggcatcca gccctgagcc cgctgtggcc aagggaggct tcctgagctt ccttgaggcc     6660

aacatgttca gcgtcatcat ccccatgtgc ctggtacttc tgctcctggc gctcatcctg     6720

cccctgctct tctacctccg aaaacgcaac aagacgggca agcatgacgt ccaggtcctg     6780

actgccaagc cccgcaacgg cctggctggt gacaccgaga cctttcgcaa ggtggagcca     6840

ggccaggcca tcccgctcac agctgtgcct ggccaggggc cccctccagg aggccagcct     6900

gacccagagc tgctgcagtt ctgccggaca cccaaccctg cccttaagaa tggccagtac     6960

tgggtgtgag gcctggcctg ggcccagatg ctgatcgggc cagggacagg c              7011


<210>  17
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  17
ggcccgggcc ccctcctttg at                                                22


<210>  18
<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  18
ggtctagatc ataatttact tcatcc                                            26


<210>  19
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  Primer

<400>  19
ggctcgagca tggagataca cc                                                22


<210>  20
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  20
ggggactagt ttatggtttc tgagaaca                                          28


<210>  21
<211>  585
<212>  DNA
<213>  Homo sapiens

<400>  21
ttcaatggcc agaggcgggg gctgcgggaa gctttgctga cgcgcaacat ggcagccggc       60

tgcaggctgg aggaggagga gtatgaggac gatgcctatg gacattatga agctttctcc      120

accctggccc ctgaggcttg gccagccatg gagctgcctg agccatgcgt gcctgagcca      180

gggctgcctc ctgtctttgc caatttcacc cagctgctga ctatcagccc actggtggtg      240

gccgaggggg gcacagcctg gcttgagtgg aggcatgtgc agcccacgct ggacctgatg      300

gaggctgagc tgcgcaaatc ccaggtgctg ttcagcgtga cccgaggggc acgccatggc      360

gagctcgagc tggacatccc gggagcccag gcacgaaaaa tgttcaccct cctggacgtg      420

gtgaaccgca aggcccgctt catccacgat ggctctgagg acacctccga ccagctggtg      480

ctggaggtgt cggtgacggc tcgggtgccc atgccctcat gccttcggag gggccaaaca      540

tacctcctgc ccatccaggt caaccctgtc aatgacccac cccac                      585


<210>  22
<211>  1290
<212>  DNA
<213>  Homo sapiens

<400>  22
gtccgcgtca ctggggccct gcagtttggg gagctgcaga aacacggggc aggtggggtg       60

gagggtgctg agtggtgggc cacacaggcg ttccaccagc gggatgtgga gcagggccgc      120

gtgaggtacc tgagcactga cccacagcac cacgcttacg acaccgtgga gaacctggcc      180

ctggaggtgc aggtgggcca ggagatcctg agcaatctgt ccttcccagt gaccatccag      240

agagccactg tgtggatgct gcggctggag ccactgcaca ctcagaacac ccagcaggag      300

accctcacca cagcccacct ggaggccacc ctggaggagg caggcccaag ccccccaacc      360

ttccattatg aggtggttca ggctcccagg aaaggcaacc ttcaactaca gggcacaagg      420

ctgtcagatg gccagggctt cacccaggat gacatacagg ctggccgggt gacctatggg      480

gccacagcac gtgcctcaga ggcagtcgag gacaccttcc gtttccgtgt cacagctcca      540

ccatatttct ccccactcta taccttcccc atccacattg gtggtgaccc agatgcgcct      600

gtcctcacca atgtcctcct cgtggtgcct gagggtggtg agggtgtcct ctctgctgac      660

cacctctttg tcaagagtct caacagtgcc agctacctct atgaggtcat ggagcggccc      720

cgccatggga ggttggcttg gcgtgggaca caggacaaga ccactatggt gacatccttc      780

accaatgaag acctgttgcg tggccggctg gtctaccagc atgatgactc cgagaccaca      840

gaagatgata tcccatttgt tgctacccgc cagggcgaga gcagtggtga catggcctgg      900

gaggaggtac ggggtgtctt ccgagtggcc atccagcccg tgaatgacca cgcccctgtg      960

cagaccatca gccggatctt ccatgtggcc cggggtgggc ggcggctgct gactacagac     1020

gacgtggcct tcagcgatgc tgactcgggc tttgctgacg cccagctggt gcttacccgc     1080

aaggacctcc tctttggcag tatcgtggcc gtagatgagc ccacgcggcc catctaccgc     1140

ttcacccagg aggacctcag gaagaggcga gtactgttcg tgcactcagg ggctgaccgt     1200

ggctggatcc agctgcaggt gtccgacggg caacaccagg ccactgcgct gctggaggtg     1260

caggcctcgg aaccctacct ccgtgtggcc                                      1290


<210>  23
<211>  294
<212>  DNA
<213>  Homo sapiens

<400>  23
gccactgagc cttacaatgc tgcccggccc tacagcgtgg ccctgctcag tgtccccgag       60

gccgcccgga cggaagcagg gaagccagag agcagcaccc ccacaggcga gccaggcccc      120

atggcatcca gccctgagcc cgctgtggcc aagggaggct tcctgagctt ccttgaggcc      180

aacatgttca gcgtcatcat ccccatgtgc ctggtacttc tgctcctggc gctcatcctg      240

cccctgctct tctacctccg aaaacgcaac aagacgggca agcatgacgt ccag            294


<210>  24
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  24
tcctcgaggt caatggccag aggcggggg                                         29


<210>  25
<211>  54
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  25
cccgggttac tacttatcgt cgtcatcctt gtaatcgtgg ggtgggtcat tgac             54


<210>  26
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  26
gcctcgagtt ccgcgtcact ggggccctg                                         29


<210>  27
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  27
actagtttac tacttatcgt cgtcatcctt gtaatcggcc acacggaggt agggttc          57


<210>  28
<211>  32
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  28
tgctcgaggc cactgagcct tacaatgctg cc                                     32


<210>  29
<211>  56
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  29
cccgggttac tacttatcgt cgtcatcctt gtaatcctgg acgtcatgct tgcccg           56


<210>  30
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  30
ggcccgggcc ccctcctttg at                                                22


<210>  31
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  31
ggtctagatc ataatttact tcatcc                                            26


<210>  32
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  32
ggtctagaga attccagcaa aagcag                                            26


<210>  33
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  33
gggtcgacaa gggtattttt ctttaat                                           27


<210>  34
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  34
ggggtctaga cctcctttga ttagtatatt c                                      31


<210>  35
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  35
atcttcgcta tctgtcgccg cggcgcgtgc ttcagtttgt tgcgc                       45


<210>  36
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  36
gcgcaacaaa ctgaagcagc ggccgcggcg acagatagcg aagat                       45


<210>  37
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  37
tgtaggtgta tctccatgct cgagagctag gcgatcaatt tc                          42


<210>  38
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  38
ggaattgatc gcctagctct cgagcatgga gatacaccta ca                          42


<210>  39
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  39
aaacggattt atttagatcc cgggttatgg tttctgagaa ca                          42


<210>  40
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  40
tgttctcaga aaccataacc cgggatctaa ataaatccgt tt                          42


<210>  41
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  41
gggggtcgac cagctcttct tggtgaag                                          28


<210>  42
<211>  9
<212>  PRT
<213>  Human papilloma virus

<400>  42

Arg Ala His Tyr Asn Ile Val Thr Phe 
1               5                   


<210>  43
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  43

Ile Leu Ser Asn Leu Ser Phe Pro Val 
1               5                   


<210>  44
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  44

Leu Leu Phe Gly Ser Ile Val Ala Val 
1               5                   


<210>  45
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  45

Leu Ile Leu Pro Leu Leu Phe Tyr Leu 
1               5                   


<210>  46
<211>  28
<212>  PRT
<213>  Listeria monocytogenes

<400>  46

Lys Glu Ser Val Val Asp Ala Ser Glu Ser Asp Leu Asp Ser Ser Met 
1               5                   10                  15      


Gln Ser Ala Asp Glu Ser Thr Pro Gln Pro Leu Lys 
            20                  25              


<210>  47
<211>  20
<212>  PRT
<213>  Listeria monocytogenes

<400>  47

Lys Ser Glu Glu Val Asn Ala Ser Asp Phe Pro Pro Pro Pro Thr Asp 
1               5                   10                  15      


Glu Glu Leu Arg 
            20  


<210>  48
<211>  33
<212>  PRT
<213>  Listeria monocytogenes

<400>  48

Arg Gly Gly Arg Pro Thr Ser Glu Glu Phe Ser Ser Leu Asn Ser Gly 
1               5                   10                  15      


Asp Phe Thr Asp Asp Glu Asn Ser Glu Thr Thr Glu Glu Glu Ile Asp 
            20                  25                  30          


Arg 
    


<210>  49
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment of Her-2/neu protein

<400>  49

Ala Ser Pro Glu Thr His Leu Asp Met Leu 
1               5                   10  


<210>  50
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment of Her-2/neu protein

<400>  50

Pro Asp Ser Leu Arg Asp Leu Ser Val Phe 
1               5                   10  


<210>  51
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment of Her-2/neu protein

<400>  51

Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 
1               5                   10  


<210>  52
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment of Flk protein

<400>  52

Thr Tyr Gln Ser Ile Met Tyr Ile Val 
1               5                   


<210>  53
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment of Flk protein

<400>  53

Met Phe Ser Asn Ser Thr Asn Asp Ile 
1               5                   


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment of Flk protein

<400>  54

Pro Gly Gly Pro Leu Met Val Ile Val 
1               5                   


<210>  55
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment of Flk protein

<400>  55

Gly Arg Gly Ala Phe Gly Gln Val Ile 
1               5                   


<210>  56
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment of Her2-pEC1302-310 protein

<400>  56

Pro Tyr Asn Tyr Leu Ser Thr Glu Val 
1               5                   


<210>  57
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment of Her2-pEC2420-429

<400>  57

Pro Asp Ser Leu Arg Asp Leu Ser Val Phe 
1               5                   10  


<210>  58
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment of Her2-pIC1732-741 protein

<400>  58

Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys 
1               5                   10  


<210>  59
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment of HIV-pGag protein

<400>  59

Ala Met Gln Met Leu Lys Glu Thr Ile 
1               5                   


<210>  60
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer for amplifying Flk fragment

<400>  60
gggctcgagc gtgattctga ggaaagggta tt                                     32


<210>  61
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer for amplifying Flk fragment

<400>  61
gggactagtt tacccggttt acaatcttct tat                                    33


<210>  62
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer for amplifying Flk fragment

<400>  62
gggctcgagg tgatcagggg tcctgaaatt a                                      31


<210>  63
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer for amplifying Flk fragment

<400>  63
gggactagtt tagcctccat cctccttcct                                        30


<210>  64
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer for amplifying Flk fragment

<400>  64
gggctcgagg aaggggaact gaagacagcc                                        30


<210>  65
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer for amplifying Flk fragment

<400>  65
gggactagtt tatgtgtata ctctgtcaaa aatggtttc                              39


<210>  66
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primers for amplifying HMW-MAA fragment

<400>  66
tgctcgaggc cactgagcct tacaatgctg cc                                     32


<210>  67
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primers for amplifying HMW-MAA fragment

<400>  67
cccgggttac tacttatcgt cgtcatcctt gtaatcctgg acgtcatgct tgcccg           56


