                         SEQUENCE LISTING

<110>  Chang, Yung
       Yan, Hao
 
<120>  NOVEL DNA NANOSTRUCTURES THAT PROMOTE CELL-CELL INTERACTION AND 
       USE THEREOF

<130>  08-1259-PCT

<150>  61/102,702
<151>  2008-10-03

<150>  61/117,418
<151>  2008-11-24

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  1616
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (78)..(911)

<400>  1
gccaaggctg gggcagggga gtcagcagag gcctcgctcg ggcgcccagt ggtcctgccg       60

cctggtctca cctcgct atg gtt cgt ctg cct ctg cag tgc gtc ctc tgg         110
                   Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp            
                   1               5                   10                 

ggc tgc ttg ctg acc gct gtc cat cca gaa cca ccc act gca tgc aga        158
Gly Cys Leu Leu Thr Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg           
            15                  20                  25                    

gaa aaa cag tac cta ata aac agt cag tgc tgt tct ttg tgc cag cca        206
Glu Lys Gln Tyr Leu Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro           
        30                  35                  40                        

gga cag aaa ctg gtg agt gac tgc aca gag ttc act gaa acg gaa tgc        254
Gly Gln Lys Leu Val Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys           
    45                  50                  55                            

ctt cct tgc ggt gaa agc gaa ttc cta gac acc tgg aac aga gag aca        302
Leu Pro Cys Gly Glu Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr           
60                  65                  70                  75            

cac tgc cac cag cac aaa tac tgc gac ccc aac cta ggg ctt cgg gtc        350
His Cys His Gln His Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val           
                80                  85                  90                

cag cag aag ggc acc tca gaa aca gac acc atc tgc acc tgt gaa gaa        398
Gln Gln Lys Gly Thr Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu           
            95                  100                 105                   

ggc tgg cac tgt acg agt gag gcc tgt gag agc tgt gtc ctg cac cgc        446
Gly Trp His Cys Thr Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg           
        110                 115                 120                       

tca tgc tcg ccc ggc ttt ggg gtc aag cag att gct aca ggg gtt tct        494
Ser Cys Ser Pro Gly Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser           
    125                 130                 135                           

gat acc atc tgc gag ccc tgc cca gtc ggc ttc ttc tcc aat gtg tca        542
Asp Thr Ile Cys Glu Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser           
140                 145                 150                 155           

tct gct ttc gaa aaa tgt cac cct tgg aca agc tgt gag acc aaa gac        590
Ser Ala Phe Glu Lys Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp           
                160                 165                 170               

ctg gtt gtg caa cag gca ggc aca aac aag act gat gtt gtc tgt ggt        638
Leu Val Val Gln Gln Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly           
            175                 180                 185                   

ccc cag gat cgg ctg aga gcc ctg gtg gtg atc ccc atc atc ttc ggg        686
Pro Gln Asp Arg Leu Arg Ala Leu Val Val Ile Pro Ile Ile Phe Gly           
        190                 195                 200                       

atc ctg ttt gcc atc ctc ttg gtg ctg gtc ttt atc aaa aag gtg gcc        734
Ile Leu Phe Ala Ile Leu Leu Val Leu Val Phe Ile Lys Lys Val Ala           
    205                 210                 215                           

aag aag cca acc aat aag gcc ccc cac ccc aag cag gaa ccc cag gag        782
Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu           
220                 225                 230                 235           

atc aat ttt ccc gac gat ctt cct ggc tcc aac act gct gct cca gtg        830
Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val           
                240                 245                 250               

cag gag act tta cat gga tgc caa ccg gtc acc cag gag gat ggc aaa        878
Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys           
            255                 260                 265                   

gag agt cgc atc tca gtg cag gag aga cag tga ggctgcaccc acccaggagt      931
Glu Ser Arg Ile Ser Val Gln Glu Arg Gln                                   
        270                 275                                           

gtggccacgt gggcaaacag gcagttggcc agagagcctg gtgctgctgc tgctgtggcg      991

tgagggtgag gggctggcac tgactgggca tagctccccg cttctgcctg cacccctgca     1051

gtttgagaca ggagacctgg cactggatgc agaaacagtt caccttgaag aacctctcac     1111

ttcaccctgg agcccatcca gtctcccaac ttgtattaaa gacagaggca gaagtttggt     1171

ggtggtggtg ttggggtatg gtttagtaat atccaccaga ccttccgatc cagcagtttg     1231

gtgcccagag aggcatcatg gtggcttccc tgcgcccagg aagccatata cacagatgcc     1291

cattgcagca ttgtttgtga tagtgaacaa ctggaagctg cttaactgtc catcagcagg     1351

agactggcta aataaaatta gaatatattt atacaacaga atctcaaaaa cactgttgag     1411

taaggaaaaa aaggcatgct gctgaatgat gggtatggaa ctttttaaaa aagtacatgc     1471

ttttatgtat gtatattgcc tatggatata tgtataaata caatatgcat catatattga     1531

tataacaagg gttctggaag ggtacacaga aaacccacag ctcgaagagt ggtgacgtct     1591

ggggtgggga agaagggtct ggggg                                           1616


<210>  2
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Gln Asp Arg Leu 
            180                 185                 190         


Arg Ala Leu Val Val Ile Pro Ile Ile Phe Gly Ile Leu Phe Ala Ile 
        195                 200                 205             


Leu Leu Val Leu Val Phe Ile Lys Lys Val Ala Lys Lys Pro Thr Asn 
    210                 215                 220                 


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
225                 230                 235                 240 


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
                245                 250                 255     


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
            260                 265                 270         


Val Gln Glu Arg Gln 
        275         


<210>  3
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
taggcagtgg tttgacgtcc gcatgttggg aatagccacg cct                         43


<210>  4
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4
tagccaaggt aaccagtaca aggtgctaaa cgtaatggct tcggcttac                   49


<210>  5
<211>  2204
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (156)..(920)

<400>  5
ggagccccgg ctcctaggct gacagaccag cccagatcca gtggcccgga ggggcctgag       60

ctaaatccgc aggacctggg taacacgagg aagtcggttt ggtcccttta gggctccgga      120

tatctttggt gacttgtcca ctccagtgtg gcatc atg tgg cag ctg ctc ctc         173
                                       Met Trp Gln Leu Leu Leu            
                                       1               5                  

cca act gct ctg cta ctt cta gtt tca gct ggc atg cgg act gaa gat        221
Pro Thr Ala Leu Leu Leu Leu Val Ser Ala Gly Met Arg Thr Glu Asp           
            10                  15                  20                    

ctc cca aag gct gtg gtg ttc ctg gag cct caa tgg tac agg gtg ctc        269
Leu Pro Lys Ala Val Val Phe Leu Glu Pro Gln Trp Tyr Arg Val Leu           
        25                  30                  35                        

gag aag gac agt gtg act ctg aag tgc cag gga gcc tac tcc cct gag        317
Glu Lys Asp Ser Val Thr Leu Lys Cys Gln Gly Ala Tyr Ser Pro Glu           
    40                  45                  50                            

gac aat tcc aca cag tgg ttt cac aat gag agc ctc atc tca agc cag        365
Asp Asn Ser Thr Gln Trp Phe His Asn Glu Ser Leu Ile Ser Ser Gln           
55                  60                  65                  70            

gcc tcg agc tac ttc att gac gct gcc aca gtc gac gac agt gga gag        413
Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr Val Asp Asp Ser Gly Glu           
                75                  80                  85                

tac agg tgc cag aca aac ctc tcc acc ctc agt gac ccg gtg cag cta        461
Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu Ser Asp Pro Val Gln Leu           
            90                  95                  100                   

gaa gtc cat atc ggc tgg ctg ttg ctc cag gcc cct cgg tgg gtg ttc        509
Glu Val His Ile Gly Trp Leu Leu Leu Gln Ala Pro Arg Trp Val Phe           
        105                 110                 115                       

aag gag gaa gac cct att cac ctg agg tgt cac agc tgg aag aac act        557
Lys Glu Glu Asp Pro Ile His Leu Arg Cys His Ser Trp Lys Asn Thr           
    120                 125                 130                           

gct ctg cat aag gtc aca tat tta cag aat ggc aaa ggc agg aag tat        605
Ala Leu His Lys Val Thr Tyr Leu Gln Asn Gly Lys Gly Arg Lys Tyr           
135                 140                 145                 150           

ttt cat cat aat tct gac ttc tac att cca aaa gcc aca ctc aaa gac        653
Phe His His Asn Ser Asp Phe Tyr Ile Pro Lys Ala Thr Leu Lys Asp           
                155                 160                 165               

agc ggc tcc tac ttc tgc agg ggg ctt ttt ggg agt aaa aat gtg tct        701
Ser Gly Ser Tyr Phe Cys Arg Gly Leu Phe Gly Ser Lys Asn Val Ser           
            170                 175                 180                   

tca gag act gtg aac atc acc atc act caa ggt ttg gca gtg tca acc        749
Ser Glu Thr Val Asn Ile Thr Ile Thr Gln Gly Leu Ala Val Ser Thr           
        185                 190                 195                       

atc tca tca ttc ttt cca cct ggg tac caa gtc tct ttc tgc ttg gtg        797
Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln Val Ser Phe Cys Leu Val           
    200                 205                 210                           

atg gta ctc ctt ttt gca gtg gac aca gga cta tat ttc tct gtg aag        845
Met Val Leu Leu Phe Ala Val Asp Thr Gly Leu Tyr Phe Ser Val Lys           
215                 220                 225                 230           

aca aac att cga agc tca aca aga gac tgg aag gac cat aaa ttt aaa        893
Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp Lys Asp His Lys Phe Lys           
                235                 240                 245               

tgg aga aag gac cct caa gac aaa tga cccccatccc atgggggtaa              940
Trp Arg Lys Asp Pro Gln Asp Lys                                           
            250                                                           

taagagcagt agcagcagca tctctgaaca tttctctgga tttgcaaccc catcatcctc     1000

aggcctctct acaagcagca ggaaacatag aactcagagc cagatccctt atccaactct     1060

cgacttttcc ttggtctcca gtggaaggga aaagcccatg atcttcaagc agggaagccc     1120

cagtgagtag ctgcattcct agaaattgaa gtttcagagc tacacaaaca ctttttctgt     1180

cccaaccgtt ccctcacagc aaagcaacaa tacaggctag ggatggtaat cctttaaaca     1240

tacaaaaatt gctcgtgtta taaattaccc agtttagagg ggaaaaaaaa acaattattc     1300

ctaaataaat ggataagtag aattaatggt tgaggcagga ccatacagag tgtgggaact     1360

gctggggatc tagggaattc agtgggacca atgaaagcat ggctgagaaa tagcaggtag     1420

tccaggatag tctaagggag gtgttcccat ctgagcccag agataagggt gtcttcctag     1480

aacattagcc gtagtggaat taacaggaaa tcatgagggt gacgtagaat tgagtcttcc     1540

aggggactct atcagaactg gaccatctcc aagtatataa cgatgagtcc tcttaatgct     1600

aggagtagaa aatggtccta ggaaggggac tgaggattgc ggtggggggt ggggtggaaa     1660

agaaagtaca gaacaaaccc tgtgtcactg tcccaagttg ctaagtgaac agaactatct     1720

cagcatcaga atgagaaagc ctgagaagaa agaaccaacc acaagcacac aggaaggaaa     1780

gcgcaggagg tgaaaatgct ttcttggcca gggtagtaag aattagaggt taatgcaggg     1840

actgtaaaac caccttttct gcttcaatat ctaattcctg tgtagctttg ttcattgcat     1900

ttattaaaca aatgttgtat aaccaatact aaatgtacta ctgagcttcg ctgagttaag     1960

ttatgaaact ttcaaatcct tcatcatgtc agttccaatg aggtggggat ggagaagaca     2020

attgttgctt atgaaagaaa gctttagctg tctctgtttt gtaagcttta agcgcaacat     2080

ttcttggttc caataaagca ttttacaaga tcttgcatgc tactcttaga tagaagatgg     2140

gaaaaccatg gtaataaaat atgaatgata aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2200

aaaa                                                                  2204


<210>  6
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Phe 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 


Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp 
225                 230                 235                 240 


Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
                245                 250                 


<210>  7
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
gctagtcaga tcgtaggtag accacgacga cacaccctaa                             40


<210>  8
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8
gctagtcaga tcgtaggtag tttttaccac gacgacacac cctaa                       45


