                         SEQUENCE LISTING

<110>  Novartis AG
       Rajuseetharaman, Gopinath
       Albee, Lee
       Patel, Mayur
       Harland, Richard
 
<120>  Bovine Herpes Virus-1 Compositions, Vaccines and Methods

<130>  PAT052820-WO-PCT

<150>  US 61/195,102
<151>  2008-10-03

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  291
<212>  DNA
<213>  Bovine herpesvirus 1

<400>  1
atgccgcggt cgccgctcat cgttgcggtt gtggccgccg cgctgtttgc catcgtgcgc       60

ggccgcgacc ccctgctaga cgcgatgcgg cgcgaggggg caatggactt ttggagcgca      120

ggctgctacg cgcgcggggt gccgctctcg gagccaccgc aggccctggt tgttttttac      180

gtggccctga ccgcggtaat ggtcgccgtg gccctgtacg cgtacgggct ttgctttagg      240

ctcatgggcg ccagcgggcc caataaaaag gagtcgcggg ggcggggctg a               291


<210>  2
<211>  96
<212>  PRT
<213>  Bovine herpesvirus 1

<400>  2

Met Pro Arg Ser Pro Leu Ile Val Ala Val Val Ala Ala Ala Leu Phe 
1               5                   10                  15      


Ala Ile Val Arg Gly Arg Asp Pro Leu Leu Asp Ala Met Arg Arg Glu 
            20                  25                  30          


Gly Ala Met Asp Phe Trp Ser Ala Gly Cys Tyr Ala Arg Gly Val Pro 
        35                  40                  45              


Leu Ser Glu Pro Pro Gln Ala Leu Val Val Phe Tyr Val Ala Leu Thr 
    50                  55                  60                  


Ala Val Met Val Ala Val Ala Leu Tyr Ala Tyr Gly Leu Cys Phe Arg 
65                  70                  75                  80  


Leu Met Gly Ala Ser Gly Pro Asn Lys Lys Glu Ser Arg Gly Arg Gly 
                85                  90                  95      


<210>  3
<211>  1380
<212>  DNA
<213>  Bovine herpesvirus 1

<400>  3
atggggctct tcaagctact gcgttacgcg tacggcaatc ggctggtaaa gcacgacgcc       60

atcaccacgc cgccgggcgt gatgaccccg atcgcggtcg acctgtggaa cgtgatgtat      120

acgctcctgg agcgcttctg cggcgacgcg cccggcggcg taggagacgc cgccgcgacc      180

gcgcgctgct tcctctcgct gctgcggatg ctgctcaagc gctcctacta cccgatcttt      240

gtagcggacc gcggcatcca cggggaccgg cgcgccacgc ggggtgccaa ggccattgtg      300

gcgcagacga tgcgcgccgt cggcggctcg ggccgcctcg ggcggctcgt cagcgacgat      360

tatacctcgg aggacgaggt gctgggcgcg tacgagtacc ccgtcccgca cgcggacgcg      420

gcagccgacg acgacgagga ggcaacggcg aaggaatttg ccgggcgcgc ctcggcgggg      480

gccgcgcggg ccaacgcgcc caagctggca catcgcgtgt gcgtgagcct catccgcttt      540

ttgggctacg cgtacgtcga cgccgctgag atggaggcag acgacgtctg cgcaaacctc      600

ttccacacaa acaccgtggc gcacatctac acgacggaca cggacatgat ccttatgggc      660

tgtgacctga ttttggacgc ggcgccgttg ttccccccga cgctacgctg ccgcgacgtg      720

ctggcgtcgc tggggctcac gtacggccag ttcctcgcga cgttcgtgcg ctgccacacc      780

gacttgcacc agccgccaat gctgcgctcg gtgcagcagg tggtgcgggg gctgcggcgc      840

gctgccgagg ccgagcccgc gactaccgag acggagtctg gctccgagcg cgagccggag      900

tccgagctcg gtcgtccggg cgctgggccg cggcgccggt tgccgcccgc ggtcgacgac      960

ccgctgaaaa ctacgacgcc ggcgaccgtg gaagcgcaca gcgtgcgcat gaagtataca     1020

tctcggtacc ctccgattgc gcagacgtgc gccgacgcgc tgcggctgct gccggcgtcc     1080

cagacgcgcg gcggcgtgct ggagcgcaaa tttgtaaagc acgtggtgga cacgatcgcg     1140

ccgcgaatgc gcgggcgctg ggccgtgctg aagcgcgtgc ccatcgcaca ggacgccccc     1200

gaccctcggc tcgtgtacga caccatcgtg agcgccgtag gcagcgccgc cgaggccgac     1260

acgctgatgg ggctcttctg gaagcacatc cccactccac ccccatttgc caaggtgctg     1320

gcagactact gggacgaggc ccccgcgggg ccggggtcgc gacggacaac ccgccaataa     1380


<210>  4
<211>  459
<212>  PRT
<213>  Bovine herpesvirus 1

<400>  4

Met Gly Leu Phe Lys Leu Leu Arg Tyr Ala Tyr Gly Asn Arg Leu Val 
1               5                   10                  15      


Lys His Asp Ala Ile Thr Thr Pro Pro Gly Val Met Thr Pro Ile Ala 
            20                  25                  30          


Val Asp Leu Trp Asn Val Met Tyr Thr Leu Leu Glu Arg Phe Cys Gly 
        35                  40                  45              


Asp Ala Pro Gly Gly Val Gly Asp Ala Ala Ala Thr Ala Arg Cys Phe 
    50                  55                  60                  


Leu Ser Leu Leu Arg Met Leu Leu Lys Arg Ser Tyr Tyr Pro Ile Phe 
65                  70                  75                  80  


Val Ala Asp Arg Gly Ile His Gly Asp Arg Arg Ala Thr Arg Gly Ala 
                85                  90                  95      


Lys Ala Ile Val Ala Gln Thr Met Arg Ala Val Gly Gly Ser Gly Arg 
            100                 105                 110         


Leu Gly Arg Leu Val Ser Asp Asp Tyr Thr Ser Glu Asp Glu Val Leu 
        115                 120                 125             


Gly Ala Tyr Glu Tyr Pro Val Pro His Ala Asp Ala Ala Ala Asp Asp 
    130                 135                 140                 


Asp Glu Glu Ala Thr Ala Lys Glu Phe Ala Gly Arg Ala Ser Ala Gly 
145                 150                 155                 160 


Ala Ala Arg Ala Asn Ala Pro Lys Leu Ala His Arg Val Cys Val Ser 
                165                 170                 175     


Leu Ile Arg Phe Leu Gly Tyr Ala Tyr Val Asp Ala Ala Glu Met Glu 
            180                 185                 190         


Ala Asp Asp Val Cys Ala Asn Leu Phe His Thr Asn Thr Val Ala His 
        195                 200                 205             


Ile Tyr Thr Thr Asp Thr Asp Met Ile Leu Met Gly Cys Asp Leu Ile 
    210                 215                 220                 


Leu Asp Ala Ala Pro Leu Phe Pro Pro Thr Leu Arg Cys Arg Asp Val 
225                 230                 235                 240 


Leu Ala Ser Leu Gly Leu Thr Tyr Gly Gln Phe Leu Ala Thr Phe Val 
                245                 250                 255     


Arg Cys His Thr Asp Leu His Gln Pro Pro Met Leu Arg Ser Val Gln 
            260                 265                 270         


Gln Val Val Arg Gly Leu Arg Arg Ala Ala Glu Ala Glu Pro Ala Thr 
        275                 280                 285             


Thr Glu Thr Glu Ser Gly Ser Glu Arg Glu Pro Glu Ser Glu Leu Gly 
    290                 295                 300                 


Arg Pro Gly Ala Gly Pro Arg Arg Arg Leu Pro Pro Ala Val Asp Asp 
305                 310                 315                 320 


Pro Leu Lys Thr Thr Thr Pro Ala Thr Val Glu Ala His Ser Val Arg 
                325                 330                 335     


Met Lys Tyr Thr Ser Arg Tyr Pro Pro Ile Ala Gln Thr Cys Ala Asp 
            340                 345                 350         


Ala Leu Arg Leu Leu Pro Ala Ser Gln Thr Arg Gly Gly Val Leu Glu 
        355                 360                 365             


Arg Lys Phe Val Lys His Val Val Asp Thr Ile Ala Pro Arg Met Arg 
    370                 375                 380                 


Gly Arg Trp Ala Val Leu Lys Arg Val Pro Ile Ala Gln Asp Ala Pro 
385                 390                 395                 400 


Asp Pro Arg Leu Val Tyr Asp Thr Ile Val Ser Ala Val Gly Ser Ala 
                405                 410                 415     


Ala Glu Ala Asp Thr Leu Met Gly Leu Phe Trp Lys His Ile Pro Thr 
            420                 425                 430         


Pro Pro Pro Phe Ala Lys Val Leu Ala Asp Tyr Trp Asp Glu Ala Pro 
        435                 440                 445             


Ala Gly Pro Gly Ser Arg Arg Thr Thr Arg Gln 
    450                 455                 


<210>  5
<211>  744
<212>  DNA
<213>  Bovine herpesvirus 1

<400>  5
atgggtgccc gcgcctccgc gcctgctgcc ggcccgcccc cagcccacgc tgttctacta       60

gatgcgctct ccgggggcac gattgacctg cctggcggcg acgaggccgt ctttgtgtcc      120

tgcccgacga cgcgccccgt gtaccaccac atgcgccgcg gccgcacggc ccacactaca      180

cccgtgcact tcgttggccg cgcctatgcc atcttgccct gccgcaagtt tatgctgtat      240

ctgatgcgcg gtggtgccgt ttacggctac gagcccacca ctggcctgca ccgcctcgcc      300

gattcactgc acgactttct tactactgcc ggactacagc agcgagacct acactgcctc      360

gatgtcacgg tgcttgacgc gcagatggac ccggtgacgt tcaccacccc cgagatcctc      420

atcgagctcg aggcggaccc ggccttccca ccgccgccct cggcccgcgc gcgccgctcc      480

acgctgcgcc gggcgtctat gcgccggccc gcacgcacct tctgccccca ccagctgcta      540

gcagagggct ccattctgga cctctgctcg ccagagcaag cggcggcgcc gggctgttcg      600

ctgctccccg cctgtgactc tggagacgcc gcgtgcccct gcgacgctgg cgagaccgcc      660

cgtgactgta ctgccgatgc cgcgcgcgct cccagccccg gcgccttatc tcgctatagc      720

tccgtgcgct cggtgttctt ttag                                             744


<210>  6
<211>  247
<212>  PRT
<213>  Bovine herpesvirus 1

<400>  6

Met Gly Ala Arg Ala Ser Ala Pro Ala Ala Gly Pro Pro Pro Ala His 
1               5                   10                  15      


Ala Val Leu Leu Asp Ala Leu Ser Gly Gly Thr Ile Asp Leu Pro Gly 
            20                  25                  30          


Gly Asp Glu Ala Val Phe Val Ser Cys Pro Thr Thr Arg Pro Val Tyr 
        35                  40                  45              


His His Met Arg Arg Gly Arg Thr Ala His Thr Thr Pro Val His Phe 
    50                  55                  60                  


Val Gly Arg Ala Tyr Ala Ile Leu Pro Cys Arg Lys Phe Met Leu Tyr 
65                  70                  75                  80  


Leu Met Arg Gly Gly Ala Val Tyr Gly Tyr Glu Pro Thr Thr Gly Leu 
                85                  90                  95      


His Arg Leu Ala Asp Ser Leu His Asp Phe Leu Thr Thr Ala Gly Leu 
            100                 105                 110         


Gln Gln Arg Asp Leu His Cys Leu Asp Val Thr Val Leu Asp Ala Gln 
        115                 120                 125             


Met Asp Pro Val Thr Phe Thr Thr Pro Glu Ile Leu Ile Glu Leu Glu 
    130                 135                 140                 


Ala Asp Pro Ala Phe Pro Pro Pro Pro Ser Ala Arg Ala Arg Arg Ser 
145                 150                 155                 160 


Thr Leu Arg Arg Ala Ser Met Arg Arg Pro Ala Arg Thr Phe Cys Pro 
                165                 170                 175     


His Gln Leu Leu Ala Glu Gly Ser Ile Leu Asp Leu Cys Ser Pro Glu 
            180                 185                 190         


Gln Ala Ala Ala Pro Gly Cys Ser Leu Leu Pro Ala Cys Asp Ser Gly 
        195                 200                 205             


Asp Ala Ala Cys Pro Cys Asp Ala Gly Glu Thr Ala Arg Asp Cys Thr 
    210                 215                 220                 


Ala Asp Ala Ala Arg Ala Pro Ser Pro Gly Ala Leu Ser Arg Tyr Ser 
225                 230                 235                 240 


Ser Val Arg Ser Val Phe Phe 
                245         


<210>  7
<211>  1014
<212>  DNA
<213>  Bovine herpesvirus 1

<400>  7
atggcgctcg ctggccttct ctcccggccg gggttgccat tgcggccgac ctcggcccgg       60

gcggctccgg ccagggccgg agcgccggcc cgccgggggt cggcggcagg ggcgcggccg      120

gcgggagacg gggtcggggc tcgggtggaa atagccgcgg cggtgctggt agccgccgcg      180

gtaacagcgg ggctcggcgc cgagctccga gcgacggaag gtgccgccgc ggcggcagtt      240

actgccgccg ccgcggccgg ggtcccaatt tgcgcacccg ccgaggccgg ccccggggcc      300

gccgcggggg ccgggtcggc ggggcgggcg ggcgcgttcg ccgtcaggtc tatcactgtg      360

gagatgggcg cgggggctgg ggccggggcc ggggccgggg tcggggcgcg gtctaactct      420

gtccttcttc tccggcgggc ctgcacacgg ggaggcccag cctccccgag cagcctggcc      480

cggcgctccc ctcgtccctc ctcactgccc gccccccagc ccgcggtctc tcccgccgcg      540

actcccaagc ccgctcccct cccctcttct ctgggctcgg ggctgcatgc gcgcgcttgc      600

gccgcggggg ctgcccgcgg cgccgccggc aatcgggggt ctcgtctccc gccgcggctc      660

cgagagctgg ggggcgcgga aactgccgcc gcgcggccgc aagggcggcg cgctagcgac      720

cgaggcgccg gctgcaccgc gggtgtttgt cgacctctag tgctgacata ctgtctttcc      780

gcaggccgcc gagcccgggc cgcgccagac gccccccgcg tgcgcctcga ctcaacctcc      840

gcgtccgtct ccggctccgt ttccgtgtcg tcaatggcgg tcaggtcgga ggtgctgagc      900

cccgacgacg actcttctga ctccgaccaa gagtcgtcct ccgagccctc cgagtccgag      960

tccgaggtgt cgagaaacac caccccacgg ccgccaggag gcgcagactg ctga           1014


<210>  8
<211>  335
<212>  PRT
<213>  Bovine herpesvirus 1

<400>  8

Met Ala Leu Ala Gly Leu Leu Ser Arg Pro Gly Leu Pro Leu Arg Pro 
1               5                   10                  15      


Thr Ser Ala Arg Ala Ala Pro Ala Arg Ala Gly Ala Pro Ala Arg Arg 
            20                  25                  30          


Gly Ser Ala Ala Gly Ala Arg Pro Ala Gly Asp Gly Val Gly Ala Arg 
        35                  40                  45              


Val Glu Ile Ala Ala Ala Val Leu Val Ala Ala Ala Val Thr Ala Gly 
    50                  55                  60                  


Leu Gly Ala Glu Leu Arg Ala Thr Glu Gly Ala Ala Ala Ala Ala Val 
65                  70                  75                  80  


Thr Ala Ala Ala Ala Ala Gly Val Pro Ile Cys Ala Pro Ala Glu Ala 
                85                  90                  95      


Gly Pro Gly Ala Ala Ala Gly Ala Gly Ser Ala Gly Arg Ala Gly Ala 
            100                 105                 110         


Phe Ala Val Arg Ser Ile Thr Val Glu Met Gly Ala Gly Ala Gly Ala 
        115                 120                 125             


Gly Ala Gly Ala Gly Val Gly Ala Arg Ser Asn Ser Val Leu Leu Leu 
    130                 135                 140                 


Arg Arg Ala Cys Thr Arg Gly Gly Pro Ala Ser Pro Ser Ser Leu Ala 
145                 150                 155                 160 


Arg Arg Ser Pro Arg Pro Ser Ser Leu Pro Ala Pro Gln Pro Ala Val 
                165                 170                 175     


Ser Pro Ala Ala Thr Pro Lys Pro Ala Pro Leu Pro Ser Ser Leu Gly 
            180                 185                 190         


Ser Gly Leu His Ala Arg Ala Cys Ala Ala Gly Ala Ala Arg Gly Ala 
        195                 200                 205             


Ala Gly Asn Arg Gly Ser Arg Leu Pro Pro Arg Leu Arg Glu Leu Gly 
    210                 215                 220                 


Gly Ala Glu Thr Ala Ala Ala Arg Pro Gln Gly Arg Arg Ala Ser Asp 
225                 230                 235                 240 


Arg Gly Ala Gly Cys Thr Ala Gly Val Cys Arg Pro Leu Val Leu Thr 
                245                 250                 255     


Tyr Cys Leu Ser Ala Gly Arg Arg Ala Arg Ala Ala Pro Asp Ala Pro 
            260                 265                 270         


Arg Val Arg Leu Asp Ser Thr Ser Ala Ser Val Ser Gly Ser Val Ser 
        275                 280                 285             


Val Ser Ser Met Ala Val Arg Ser Glu Val Leu Ser Pro Asp Asp Asp 
    290                 295                 300                 


Ser Ser Asp Ser Asp Gln Glu Ser Ser Ser Glu Pro Ser Glu Ser Glu 
305                 310                 315                 320 


Ser Glu Val Ser Arg Asn Thr Thr Pro Arg Pro Pro Gly Gly Ala 
                325                 330                 335 


<210>  9
<211>  545
<212>  DNA
<213>  Bovine herpesvirus 1

<400>  9
atgcgcgacc tgggccataa aagccccgcg catgcgcgag cagttacttt cggtttgggg       60

atgacagcgg cgactgcggc tcgaaagtta agtatgcagg ctgggggtcg caaatacacg      120

gcggtgcggt gtggtgggct gcgggtcgcg gagtgggtgg gcggggagcc ggccgcggcg      180

attattgccg ccaggcgctg ccgccgctgc agcggccgag cagcccggcc aggctcgggc      240

cctggcgacc gcctggctgc ggcgccaggg ccgcgctgct gcggcggggg gtccccagga      300

ggctttctcg cacccaggcg gccacttcca tttcggtgcg ccgcctcttc tgcgccgagc      360

tctcggggcc ggggtccagg tcgccccgcg ccatggcgct cgctggcctt ctctcccggc      420

cggggttgcc attgcggccg acctcggccc gggcggctcc ggccagggcc ggagcgccgg      480

cccgccgggg gtcggcggca ggggcgcggc cggcgggaga cggggtcggg gctcgggtgg      540

aaata                                                                  545


<210>  10
<211>  181
<212>  PRT
<213>  Bovine herpesvirus 1

<400>  10

Met Arg Asp Leu Gly His Lys Ser Pro Ala His Ala Arg Ala Val Thr 
1               5                   10                  15      


Phe Gly Leu Gly Met Thr Ala Ala Thr Ala Ala Arg Lys Leu Ser Met 
            20                  25                  30          


Gln Ala Gly Gly Arg Lys Tyr Thr Ala Val Arg Cys Gly Gly Leu Arg 
        35                  40                  45              


Val Ala Glu Trp Val Gly Gly Glu Pro Ala Ala Ala Ile Ile Ala Ala 
    50                  55                  60                  


Arg Arg Cys Arg Arg Cys Ser Gly Arg Ala Ala Arg Pro Gly Ser Gly 
65                  70                  75                  80  


Pro Gly Asp Arg Leu Ala Ala Ala Pro Gly Pro Arg Cys Cys Gly Gly 
                85                  90                  95      


Gly Ser Pro Gly Gly Phe Leu Ala Pro Arg Arg Pro Leu Pro Phe Arg 
            100                 105                 110         


Cys Ala Ala Ser Ser Ala Pro Ser Ser Arg Gly Arg Gly Pro Gly Arg 
        115                 120                 125             


Pro Ala Pro Trp Arg Ser Leu Ala Phe Ser Pro Gly Arg Gly Cys His 
    130                 135                 140                 


Cys Gly Arg Pro Arg Pro Gly Arg Leu Arg Pro Gly Pro Glu Arg Arg 
145                 150                 155                 160 


Pro Ala Gly Gly Arg Arg Gln Gly Arg Gly Arg Arg Glu Thr Gly Ser 
                165                 170                 175     


Gly Leu Gly Trp Lys 
            180     


<210>  11
<211>  1335
<212>  DNA
<213>  Bovine herpesvirus 1

<400>  11
atgcctgccg cccggaccgg caccttggcc gccgtcgccc taatcctgct ctgcggggcc       60

gccgttttgg ggcgccccgc gcccgacgac ctctgtttcg ccgacgtgcg ccgcactggc      120

atggcgccct cccgcccgct ggggcccgtc ctgaacctag cggcctcgga tttgacctcg      180

cgggtttcgg tgcgcgcggt ggacgcttcg cgcggctgcg ccctggccct cttggacatg      240

gcggagacgg tggtgcccgg cggaccgcga gccgccgacg tcgtcgacgt cggctgggct      300

taccaagacg gggactgcat ggtgcctctg gcatatcgcc agtactttaa ctgcacgggg      360

ggcgcgctgc ccggccaaaa cgtctgcgcc gggctctctg agacccgcat ccgcggtggc      420

tttggaacct ccgactacgc gctctacggg acgtcgctag tactgcgccc cggcctgtac      480

gaccgcggga cctacatcta cttccttgga tacggcccag acgacatcta cgtgggcagc      540

gtcacgctca tggtgggcgc cgacatccac aaatacccct gcgggctgga ccgagggctc      600

ggtgtggccc tgcaccacaa gagcggaccg gcccgacctc tgacagagga cgacgccacc      660

ggcgactggg cctgcggctg cttccccgcc cttgttgagg ttgacgcggt gtggggcaac      720

gtaagcgccg cagagctggg cctggccgac ccgatcgact acgccgacga agggggtgag      780

gtcgaagtgc tcgaggacga agccgggagc gccagcggaa acctgccgca ggacgacccc      840

gaccccgacc tcgcagattg ccggaccgtc gggctcttta gcgaaagcga catgttccgg      900

accgccagcg ggcccgaatc gctgctgatc ggcgccgttg ccaaggacgt cctgacggtg      960

cccctcaatc tgccgcccgg ccgctcttac gaggccctgc gaaacgcatc gctggagtgc     1020

aactcccgcc cgcgcgagac cggcgacgca gcggtggtgg tgatgtctct ccaggagccc     1080

gctcgcctcg agcgccgccc cgatgcccgc gccaccgatc cggagtttgg gctctttggc     1140

ctgcccgatg accccgccgt gcggcgcggc attctcatcg gcctcgcgat cgctctgctg     1200

gtgctgctgt tttcgctggt gatcgtgctc gtctgcgcct gccggctcgc ccgcgcagcc     1260

aaggctgcgc gacgcgcccg cgccgccacg ttcgccaaga gcaaccccgc gtacgagccg     1320

atgctcagcg tctga                                                      1335


<210>  12
<211>  444
<212>  PRT
<213>  Bovine herpesvirus 1

<400>  12

Met Pro Ala Ala Arg Thr Gly Thr Leu Ala Ala Val Ala Leu Ile Leu 
1               5                   10                  15      


Leu Cys Gly Ala Ala Val Leu Gly Arg Pro Ala Pro Asp Asp Leu Cys 
            20                  25                  30          


Phe Ala Asp Val Arg Arg Thr Gly Met Ala Pro Ser Arg Pro Leu Gly 
        35                  40                  45              


Pro Val Leu Asn Leu Ala Ala Ser Asp Leu Thr Ser Arg Val Ser Val 
    50                  55                  60                  


Arg Ala Val Asp Ala Ser Arg Gly Cys Ala Leu Ala Leu Leu Asp Met 
65                  70                  75                  80  


Ala Glu Thr Val Val Pro Gly Gly Pro Arg Ala Ala Asp Val Val Asp 
                85                  90                  95      


Val Gly Trp Ala Tyr Gln Asp Gly Asp Cys Met Val Pro Leu Ala Tyr 
            100                 105                 110         


Arg Gln Tyr Phe Asn Cys Thr Gly Gly Ala Leu Pro Gly Gln Asn Val 
        115                 120                 125             


Cys Ala Gly Leu Ser Glu Thr Arg Ile Arg Gly Gly Phe Gly Thr Ser 
    130                 135                 140                 


Asp Tyr Ala Leu Tyr Gly Thr Ser Leu Val Leu Arg Pro Gly Leu Tyr 
145                 150                 155                 160 


Asp Arg Gly Thr Tyr Ile Tyr Phe Leu Gly Tyr Gly Pro Asp Asp Ile 
                165                 170                 175     


Tyr Val Gly Ser Val Thr Leu Met Val Gly Ala Asp Ile His Lys Tyr 
            180                 185                 190         


Pro Cys Gly Leu Asp Arg Gly Leu Gly Val Ala Leu His His Lys Ser 
        195                 200                 205             


Gly Pro Ala Arg Pro Leu Thr Glu Asp Asp Ala Thr Gly Asp Trp Ala 
    210                 215                 220                 


Cys Gly Cys Phe Pro Ala Leu Val Glu Val Asp Ala Val Trp Gly Asn 
225                 230                 235                 240 


Val Ser Ala Ala Glu Leu Gly Leu Ala Asp Pro Ile Asp Tyr Ala Asp 
                245                 250                 255     


Glu Gly Gly Glu Val Glu Val Leu Glu Asp Glu Ala Gly Ser Ala Ser 
            260                 265                 270         


Gly Asn Leu Pro Gln Asp Asp Pro Asp Pro Asp Leu Ala Asp Cys Arg 
        275                 280                 285             


Thr Val Gly Leu Phe Ser Glu Ser Asp Met Phe Arg Thr Ala Ser Gly 
    290                 295                 300                 


Pro Glu Ser Leu Leu Ile Gly Ala Val Ala Lys Asp Val Leu Thr Val 
305                 310                 315                 320 


Pro Leu Asn Leu Pro Pro Gly Arg Ser Tyr Glu Ala Leu Arg Asn Ala 
                325                 330                 335     


Ser Leu Glu Cys Asn Ser Arg Pro Arg Glu Thr Gly Asp Ala Ala Val 
            340                 345                 350         


Val Val Met Ser Leu Gln Glu Pro Ala Arg Leu Glu Arg Arg Pro Asp 
        355                 360                 365             


Ala Arg Ala Thr Asp Pro Glu Phe Gly Leu Phe Gly Leu Pro Asp Asp 
    370                 375                 380                 


Pro Ala Val Arg Arg Gly Ile Leu Ile Gly Leu Ala Ile Ala Leu Leu 
385                 390                 395                 400 


Val Leu Leu Phe Ser Leu Val Ile Val Leu Val Cys Ala Cys Arg Leu 
                405                 410                 415     


Ala Arg Ala Ala Lys Ala Ala Arg Arg Ala Arg Ala Ala Thr Phe Ala 
            420                 425                 430         


Lys Ser Asn Pro Ala Tyr Glu Pro Met Leu Ser Val 
        435                 440                 


<210>  13
<211>  435
<212>  DNA
<213>  Bovine herpesvirus 1

<400>  13
atggagagtc cacgcagcgt cgtcaacgaa aactatcgag gcgctgatga ggccgatgca       60

gcgccccctt caccgccgcc ggaaggctcc atcgtgtcca tccccatcct cgagctcacc      120

atcgaggacg cgccggccag cgcagaagca accggcaccg cggcagccgc acccgctggg      180

cgcactccag acgcgaacgc agcacccggc ggctacgtgc cagttcccgc ggcggatgtg      240

gactgctatt atagcgaaag cgacagcgag acggcaggcg agtttttgat acgcatgggg      300

cggcagcagc ggcggcggca tcggcggcgg cgctgcatga tagcagcggc cctgacttgc      360

attggcctcg gggcctgcgc ggcggcggca gcggcaggcg ccgtcctggc gttggaggta      420

gtgccccggc cctga                                                       435


<210>  14
<211>  144
<212>  PRT
<213>  Bovine herpesvirus 1

<400>  14

Met Glu Ser Pro Arg Ser Val Val Asn Glu Asn Tyr Arg Gly Ala Asp 
1               5                   10                  15      


Glu Ala Asp Ala Ala Pro Pro Ser Pro Pro Pro Glu Gly Ser Ile Val 
            20                  25                  30          


Ser Ile Pro Ile Leu Glu Leu Thr Ile Glu Asp Ala Pro Ala Ser Ala 
        35                  40                  45              


Glu Ala Thr Gly Thr Ala Ala Ala Ala Pro Ala Gly Arg Thr Pro Asp 
    50                  55                  60                  


Ala Asn Ala Ala Pro Gly Gly Tyr Val Pro Val Pro Ala Ala Asp Val 
65                  70                  75                  80  


Asp Cys Tyr Tyr Ser Glu Ser Asp Ser Glu Thr Ala Gly Glu Phe Leu 
                85                  90                  95      


Ile Arg Met Gly Arg Gln Gln Arg Arg Arg His Arg Arg Arg Arg Cys 
            100                 105                 110         


Met Ile Ala Ala Ala Leu Thr Cys Ile Gly Leu Gly Ala Cys Ala Ala 
        115                 120                 125             


Ala Ala Ala Ala Gly Ala Val Leu Ala Leu Glu Val Val Pro Arg Pro 
    130                 135                 140                 


<210>  15
<211>  1728
<212>  DNA
<213>  Bovine herpesvirus 1

<400>  15
atgcaaccca ccgcgccgcc ccggcggcgg ttgctgccgc tgctgctgcc gcagttattg       60

cttttcgggc tgatggccga ggccaagccc gcgaccgaaa ccccgggctc ggcttcggtc      120

gacacggtct tcacggcgcg cgctggcgcg cccgtctttc tcccagggcc cgcggcgcgc      180

ccggacgtgc gcgccgttcg cggctggagc gtcctcgcgg gcgcctgctc gccgcccgtg      240

ccggagcccg tctgcctcga cgaccgcgag tgcttcaccg acgtggccct ggacgcggcc      300

tgcctgcgaa ccgcccgcgt ggccccgctg gccatcgcgg agctcgccga gcggcccgac      360

tcaacgggcg acaaagagtt tgttctcgcc gacccgcacg tctcggcgca gctgggtcgc      420

aacgcgaccg gggtgctgat cgcggccgca gccgaggagg acggcggcgt gtacttcctg      480

tacgaccggc tcatcggcga cgccggcgac gaggagacgc agttggcgct gacgctgcag      540

gtcgcgacgg ccggcgcgca gggcgccgcg cgggacgagg agagggaacc agcgaccggg      600

cccacccccg gcccgccgcc ccaccgcacg acgacacgcg cgcccccgcg gcggcacggc      660

gcgcgcttcc gcgtgctgcc gtaccactcc cacgtataca ccccgggcga ttcctttctg      720

ctatcggtgc gtctgcagtc tgagtttttc gacgaggctc ccttctcggc cagcatcgac      780

tggtacttcc tgcggacggc cggcgactgc gcgctcatcc gcatatacga gacgtgcatc      840

ttccaccccg aggcaccggc ctgcctgcac cccgccgacg cgcagtgcag cttcgcgtcg      900

ccgtaccgct ccgagaccgt gtacagccgg ctgtacgagc agtgccgccc ggaccctgcc      960

ggtcgctggc cgcacgagtg cgagggcgcc gcgtacgcgg cgcccgttgc gcacctgcgt     1020

cccgccaata acagcgtaga cctggtcttt gacgacgcgc cggctgcggc ctccgggctt     1080

tacgtctttg tgctgcagta caacggccac gtggaagctt gggactacag cctagtcgtt     1140

acttcggacc gtttggtgcg cgcggtcacc gaccacacgc gccccgaggc cgcagccgcc     1200

gacgctcccg agccaggccc accgctcacc agcgagccgg cgggcgcgcc caccgggccc     1260

gcgccctggc ttgtggtgct ggtgggcgcg cttggactcg cgggactggt gggcatcgca     1320

gccctcgccg ttcgggtgtg cgcgcgccgc gcaagccaga agcgcaccta cgacatcctc     1380

aaccccttcg ggcccgtata caccagcttg ccgaccaacg agccgctcga cgtggtggtg     1440

ccagttagcg acgacgaatt ttccctcgac gaagactctt ttgcggatga cgacagcgac     1500

gatgacgggc ccgctagcaa cccccctgcg gatgcctacg acctcgccgg cgccccagag     1560

ccaactagcg ggtttgcgcg agcccccgcc aacggcacgc gctcgagtcg ctctgggttc     1620

aaagtttggt ttagggaccc gcttgaagac gatgccgcgc cagcgcggac cccggccgca     1680

ccagattaca ccgtggtagc agcgcgactc aagtccatcc tccgctag                  1728


<210>  16
<211>  575
<212>  PRT
<213>  Bovine herpesvirus 1

<400>  16

Met Gln Pro Thr Ala Pro Pro Arg Arg Arg Leu Leu Pro Leu Leu Leu 
1               5                   10                  15      


Pro Gln Leu Leu Leu Phe Gly Leu Met Ala Glu Ala Lys Pro Ala Thr 
            20                  25                  30          


Glu Thr Pro Gly Ser Ala Ser Val Asp Thr Val Phe Thr Ala Arg Ala 
        35                  40                  45              


Gly Ala Pro Val Phe Leu Pro Gly Pro Ala Ala Arg Pro Asp Val Arg 
    50                  55                  60                  


Ala Val Arg Gly Trp Ser Val Leu Ala Gly Ala Cys Ser Pro Pro Val 
65                  70                  75                  80  


Pro Glu Pro Val Cys Leu Asp Asp Arg Glu Cys Phe Thr Asp Val Ala 
                85                  90                  95      


Leu Asp Ala Ala Cys Leu Arg Thr Ala Arg Val Ala Pro Leu Ala Ile 
            100                 105                 110         


Ala Glu Leu Ala Glu Arg Pro Asp Ser Thr Gly Asp Lys Glu Phe Val 
        115                 120                 125             


Leu Ala Asp Pro His Val Ser Ala Gln Leu Gly Arg Asn Ala Thr Gly 
    130                 135                 140                 


Val Leu Ile Ala Ala Ala Ala Glu Glu Asp Gly Gly Val Tyr Phe Leu 
145                 150                 155                 160 


Tyr Asp Arg Leu Ile Gly Asp Ala Gly Asp Glu Glu Thr Gln Leu Ala 
                165                 170                 175     


Leu Thr Leu Gln Val Ala Thr Ala Gly Ala Gln Gly Ala Ala Arg Asp 
            180                 185                 190         


Glu Glu Arg Glu Pro Ala Thr Gly Pro Thr Pro Gly Pro Pro Pro His 
        195                 200                 205             


Arg Thr Thr Thr Arg Ala Pro Pro Arg Arg His Gly Ala Arg Phe Arg 
    210                 215                 220                 


Val Leu Pro Tyr His Ser His Val Tyr Thr Pro Gly Asp Ser Phe Leu 
225                 230                 235                 240 


Leu Ser Val Arg Leu Gln Ser Glu Phe Phe Asp Glu Ala Pro Phe Ser 
                245                 250                 255     


Ala Ser Ile Asp Trp Tyr Phe Leu Arg Thr Ala Gly Asp Cys Ala Leu 
            260                 265                 270         


Ile Arg Ile Tyr Glu Thr Cys Ile Phe His Pro Glu Ala Pro Ala Cys 
        275                 280                 285             


Leu His Pro Ala Asp Ala Gln Cys Ser Phe Ala Ser Pro Tyr Arg Ser 
    290                 295                 300                 


Glu Thr Val Tyr Ser Arg Leu Tyr Glu Gln Cys Arg Pro Asp Pro Ala 
305                 310                 315                 320 


Gly Arg Trp Pro His Glu Cys Glu Gly Ala Ala Tyr Ala Ala Pro Val 
                325                 330                 335     


Ala His Leu Arg Pro Ala Asn Asn Ser Val Asp Leu Val Phe Asp Asp 
            340                 345                 350         


Ala Pro Ala Ala Ala Ser Gly Leu Tyr Val Phe Val Leu Gln Tyr Asn 
        355                 360                 365             


Gly His Val Glu Ala Trp Asp Tyr Ser Leu Val Val Thr Ser Asp Arg 
    370                 375                 380                 


Leu Val Arg Ala Val Thr Asp His Thr Arg Pro Glu Ala Ala Ala Ala 
385                 390                 395                 400 


Asp Ala Pro Glu Pro Gly Pro Pro Leu Thr Ser Glu Pro Ala Gly Ala 
                405                 410                 415     


Pro Thr Gly Pro Ala Pro Trp Leu Val Val Leu Val Gly Ala Leu Gly 
            420                 425                 430         


Leu Ala Gly Leu Val Gly Ile Ala Ala Leu Ala Val Arg Val Cys Ala 
        435                 440                 445             


Arg Arg Ala Ser Gln Lys Arg Thr Tyr Asp Ile Leu Asn Pro Phe Gly 
    450                 455                 460                 


Pro Val Tyr Thr Ser Leu Pro Thr Asn Glu Pro Leu Asp Val Val Val 
465                 470                 475                 480 


Pro Val Ser Asp Asp Glu Phe Ser Leu Asp Glu Asp Ser Phe Ala Asp 
                485                 490                 495     


Asp Asp Ser Asp Asp Asp Gly Pro Ala Ser Asn Pro Pro Ala Asp Ala 
            500                 505                 510         


Tyr Asp Leu Ala Gly Ala Pro Glu Pro Thr Ser Gly Phe Ala Arg Ala 
        515                 520                 525             


Pro Ala Asn Gly Thr Arg Ser Ser Arg Ser Gly Phe Lys Val Trp Phe 
    530                 535                 540                 


Arg Asp Pro Leu Glu Asp Asp Ala Ala Pro Ala Arg Thr Pro Ala Ala 
545                 550                 555                 560 


Pro Asp Tyr Thr Val Val Ala Ala Arg Leu Lys Ser Ile Leu Arg 
                565                 570                 575 


<210>  17
<211>  1026
<212>  DNA
<213>  Bovine herpesvirus 1

<400>  17
aagcttaaag aagggcactt cgacgcccgc ctctgtcccg gcgtttgcgt cgtcgtcgac       60

ggcgatgagg cgaggcagcg tggtggttag ccgcgcgagc gtcagccgca gcgcaagccc      120

cgccggggga gcggccgctg cggactcggg cgcccagacg atggcgcgca agatccccga      180

gtagcccgag tcgacgatgc cgacggccac ggctggtggg cggggcatgt gtgtgtcacc      240

cgagcgcatt tgcgacatta taatggcata tccgccgggc gcggccgcct tcatgtttaa      300

gttaatcagc cggctataaa ggagagatcc cgacggggct gtttcatctc gctttgctgc      360

tggcgcaatt gggccccaga gcgccagcga gtcgggctca cagcagcttt ccaaccgcca      420

gggggccgcc tccgcgttga gctctacgac gaggatcccg cggtcgccgc tcatcgttgc      480

ggttgtggcc gccgcgctgt ttgccatatt aatgatatcc ttaagtgatt gaccgcaacg      540

ctgcggagta acttgtatat aaagctcgcg gtcccggcga ccgctgcctt tttcgcactc      600

ggcccgaccc gctttgagct gcacgcccgc cggcccgccg actcgcttgc catggcccgg      660

ttccacaggc cctccgaaga cgaggacgat tacgagtaca gcgacctttg ggtgcgagaa      720

aacagcctct atgactacga gtccggctcg gatgaccacg tatacgaaga gctgcgcgcc      780

gcgacgagcg gacccgagcc gagcgggcgg cgcgctagcg tccgtgcgtg cgccagcgct      840

gcagccgtcc agcccgccgc ccgcggccgc gatcgagccg cagccgcggg gacgaccgta      900

gctgcgcccg ccgccgcgcc ggcccgccgc tcgagcagcc gggcgtcctc gcgcccgccg      960

cgagctgccg ccgacccgcc cgtcctccgg ccagccacgc gcgggtcctc cggcggcgcc     1020

ggggca                                                                1026


<210>  18
<211>  1030
<212>  DNA
<213>  Bovine herpesvirus 1

<400>  18
aagcttctgg catacccgcg cgcgctgttc gacagccccg cgggcccgca gggcgaggac       60

gccgaggcat cgggcccgcc gacgatcttg ggcgaccgcg actgcgcccg gcagctgctc      120

cgcgtgattc gccggctggc cgtgcacgcc gaagagtttc cacccagccc cactgaccgg      180

ctgacccgca acttcaagcg ccacgcgagc acgcgccgag agccgcacag cccgtaccgc      240

tgcctggcgg tgctccggct gccctgcgac gccgaccgcc tcctacacca gatgctgacc      300

tttgactttc gcgcgcgccc caccgccgcg gagctgctgg agcaccccgt cttcggtgcg      360

gcctcggggt agccccgggg gtttcccgca aaactgaggc atataaggcg cgggcaccgg      420

caagtttggc atccacactt cgcgctgtgg acacgagagc gaacgcgagc gaacgcgagc      480

gcaagcgcga gcacacgact gcgatcatta atgatatcct taagtcgccg gcaccccacg      540

ccgccccgac cccgctgtcc cgcgtttaca ataaacagtt attcttacca acgttggtgc      600

gcctgtcgcg tgtctattgc gagttaaacc gagtgcccca cccaggcagg gcgggggttg      660

ggccgggccg cagccccggc tgggtatata tccccgacgg gcgactagag atacactcgc      720

cccgcgcggc tgctgcgagc gggcgaacat gcaagggccg acattggccg tgctgggcgc      780

gctgctcgcc gttgcggtga gcttgcctac acccgcgccg cgggtgacgg tatacgtcga      840

cccgccggcg tacccgatgc cgcgatacaa ctacactgaa cgctggcaca ctaccgggcc      900

cataccgtcg cccttcgcag acggccgcga gcagcccgtc gaggtgcgct acgcgacgag      960

cgcggcggcg tgcgacatgc tggcgctgat cgcagacccg caggtggggc gcacgctgtg     1020

ggaatctaga                                                            1030


<210>  19
<211>  1031
<212>  DNA
<213>  Bovine herpesvirus 1

<400>  19
aagcttcttc tcggcgggga cggccacgta cacttgctcg tcgtagaggc cgctgtgtac       60

cagcatgccc tcgcggctaa agaccaaaaa ggcgtttcgc agcgaggcgc caaaggggct      120

cagcagggcg gagacgtccg ccagctggcg gccgataagc gaggcgctcg cgattgggtt      180

gccgttgccg ccgtcggaca gaccggcggt gaggcgggcc tcgccttcgt cggcgcgcag      240

atgcgagggg ggctgcagca tcgcggcggg tgcttcggcg gcgctttcgc tcgcctctta      300

cgcgcgcggt cgcaaagcga gtctgcgctg cggcggcgct ctttatactg ggcggacgcc      360

cccgcagcgg caaaacacac actcggcggc ctcagcgtat caaacggcga cacgtttaag      420

tttcgacgcc tataagcggg cgcgcgcact aggcctccca atcggcaccg cgcgcggctg      480

tgcgggcgac cctgcgcaga gagagattaa tgatatcctt aagaaacgcg cgcatacgcg      540

agactggctt tcgttgacat ggaacatttt ttattcgcgg cgtgggggtg agaaggagga      600

ggaaaggcgg ggcgctctgg cagggcagcg ggggtgccct acaggtcgtt gattacggtg      660

cctgtgtagt tggtgctgcg gcgctcaaag aagttcgtgt gcttctcggc agtcatcagg      720

gccaaaggaa aatcggtccc aggaggcggg gtgccaaaca gaggaggcag ctggatagca      780

gcgagcaggc ggtccgcgct gtactcgacg tacgcagaaa tagcctccac gtcaagtata      840

tgactgccgc gcggcgcgca accaaataaa ctcgcgctca atttccacgc ttcgcggaac      900

agctcgtaga tgcgggccgg cggcggccgc tccccgccga ggtagttgtc gaagatgcag      960

cacgacgcgg ccgtgtgcac ggcttcgtcg cggctgatga ggtcgttggt ttggcacgtc     1020

acgactctag a                                                          1031


<210>  20
<211>  1022
<212>  DNA
<213>  Bovine herpesvirus 1

<400>  20
aagcttctct accctcctcc ctcgaggcag gcgcaacgga ccccgcccag tccatcccac       60

ttcgcacaat cgccaaattt ttgtccatta gctaaaagta tctccggcca taatcgatgt      120

gtctgagagg gtaataaaac acacccagac gctcggcact tagctctcga gtgattgcct      180

ggctgcttgc cccgtttgcg tggaatgagg ccaaacaagc atttggcccc tgtttggcta      240

gacggggctt tgtgtttttc ccacccctgc ccttgcccct ggccgcctgg ccggccggct      300

aaagtatagg ccagaccaaa ccccccgcag cagctctgct cgctggcgag accccaaagc      360

gccaattgtg gcatatttcc gggtctgacc gcgcctgcac ttgcctttgg cagtaatatt      420

attaatgata tccttaagtc agagtttaat attacagaca gacaaaaagc cagataatta      480

caaagtattt gtttttattg attgcgcatg cagaattcta gttagttagc atgcgcgagc      540

agttactttc ggtttgggga tgacagcggc gactgcggct cgaaagttaa gtatgcaggc      600

tgggggtcgc aaatacacgg cggtgcggtg tggtgggctg cgggtcgcgg agtgggtggg      660

cggggagccg gccgcggcga ttattgccgc caggcgctgc cgccgctgca gcggccgagc      720

agcccggcca ggctcgggcc ctggcgaccg cctggctgcg gcgccagggc cgcgctgctg      780

cggcgggggg tccccaggag gctttctcgc acccaggcgg ccacttccat ttcggtgcgc      840

cgcctcttct gcgccgagct ctcggggccg gggtccaggt cgccccgcgc catggcgctc      900

gctggccttc tctcccggcc ggggttgcca ttgcggccga cctcggcccg ggcggctccg      960

gccagggccg gagcgccggc ccgccggggg tcggcggcag gggcgcggcc ggcgggtcta     1020

ga                                                                    1022


<210>  21
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence encoding four repeats of -Gly-Ser- designed for 
       insertion into a Bovine Herpes virus gene to construct a mutant 
       gene (insertion mutant)

<400>  21
ggatctggta gtggctccgg gagc                                              24


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide encoded by nucleotide designed for insertion into 
       wild-type Bovine Herpes virus gene to create a mutant gene 
       (insertion mutant)

<400>  22

Gly Ser Gly Ser Gly Ser Gly Ser 
1               5               


<210>  23
<211>  300
<212>  DNA
<213>  Bovine herpesvirus 1

<400>  23
atgccgcggt cgccgctcat cgttgcggtt gtggccgccg cgctgtttgc catcgtgcgc       60

ggccgcgacc cctagtaagc tttgctagac gcgatgcggc gcgagggggc aatggacttt      120

tggagcgcag gctgctacgc gcgcggggtg ccgctctcgg agccaccgca ggccctggtt      180

gttttttacg tggccctgac cgcggtaatg gtcgccgtgg ccctgtacgc gtacgggctt      240

tgctttaggc tcatgggcgc cagcgggccc aataaaaagg agtcgcgggg gcggggctga      300


