                         SEQUENCE LISTING

<110>  PIERRE FABRE MEDICAMENT
        
<120>  Novel anti CXCR4 antibodies and their use for the treatment of 
       cancer

<130>  D26935

<150>  EP 08305631.7
<151>  2008-10-01

<150>  US 61/136,772
<151>  2008-10-01

<150>  US 61/173,743
<151>  2009-04-29

<160>  71    

<170>  PatentIn version 3.3

<210>  1
<211>  12
<212>  PRT
<213>  mus musculus

<400>  1

Gln Ser Leu Tyr Asn Ser Arg Thr Arg Lys Asn Tyr 
1               5                   10          


<210>  2
<211>  3
<212>  PRT
<213>  mus musculus

<400>  2

Trp Ala Ser 
1           


<210>  3
<211>  8
<212>  PRT
<213>  mus musculus

<400>  3

Lys Gln Ser Tyr Asn Leu Arg Thr 
1               5               


<210>  4
<211>  4
<212>  PRT
<213>  mus musculus

<400>  4

Thr Asp Tyr Tyr 
1               


<210>  5
<211>  10
<212>  PRT
<213>  mus musculus

<400>  5

Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr 
1               5                   10  


<210>  6
<211>  7
<212>  PRT
<213>  mus musculus

<400>  6

Asp Ile Pro Gly Phe Ala Tyr 
1               5           


<210>  7
<211>  8
<212>  PRT
<213>  mus musculus

<400>  7

Gly Phe Thr Phe Thr Asp Tyr Tyr 
1               5               


<210>  8
<211>  9
<212>  PRT
<213>  mus musculus

<400>  8

Ala Arg Asp Ile Pro Gly Phe Ala Tyr 
1               5                   


<210>  9
<211>  17
<212>  PRT
<213>  mus musculus

<400>  9

Lys Ser Ser Gln Ser Leu Tyr Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala


<210>  10
<211>  7
<212>  PRT
<213>  mus musculus

<400>  10

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  11
<211>  6
<212>  PRT
<213>  mus musculus

<400>  11

Thr Asp Tyr Tyr Met Ser 
1               5       


<210>  12
<211>  19
<212>  PRT
<213>  mus musculus

<400>  12

Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu Tyr Ser Ala Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  13
<211>  112
<212>  PRT
<213>  mus musculus

<400>  13

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Tyr Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Thr Ser Val Gln Ala Glu Asp Leu Ala Val Phe Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  14
<211>  118
<212>  PRT
<213>  mus musculus

<400>  14

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Thr Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ser Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Thr Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Ser Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Ile Pro Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  15
<211>  36
<212>  DNA
<213>  mus musculus

<400>  15
cagagtctgt acaacagtag aacccgaaag aactac                               36


<210>  16
<211>  9
<212>  DNA
<213>  mus musculus

<400>  16
tgggcatcc                                                              9


<210>  17
<211>  24
<212>  DNA
<213>  mus musculus

<400>  17
aagcaatctt ataatcttcg gacg                                            24


<210>  18
<211>  12
<212>  DNA
<213>  mus musculus

<400>  18
actgattact ac                                                         12


<210>  19
<211>  30
<212>  DNA
<213>  mus musculus

<400>  19
attagaaaca aagctaatgg ttacacaaca                                      30


<210>  20
<211>  21
<212>  DNA
<213>  mus musculus

<400>  20
gatatcccgg ggtttgctta c                                               21


<210>  21
<211>  24
<212>  DNA
<213>  mus musculus

<400>  21
gggttcacct tcactgatta ctac                                            24


<210>  22
<211>  27
<212>  DNA
<213>  mus musculus

<400>  22
gcaagagata tcccggggtt tgcttac                                         27


<210>  23
<211>  51
<212>  DNA
<213>  mus musculus

<400>  23
aaatccagtc agagtctgta caacagtaga acccgaaaga actacttggc t              51


<210>  24
<211>  21
<212>  DNA
<213>  mus musculus

<400>  24
tgggcatcca ctagggaatc t                                               21


<210>  25
<211>  18
<212>  DNA
<213>  mus musculus

<400>  25
actgattact acatgagc                                                   18


<210>  26
<211>  57
<212>  DNA
<213>  mus musculus

<400>  26
tttattagaa acaaagctaa tggttacaca acagagtaca gtgcatctgt gaagggt        57


<210>  27
<211>  336
<212>  DNA
<213>  mus musculus

<400>  27
gacattgtga tgtcacagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact     60

atgagctgca aatccagtca gagtctgtac aacagtagaa cccgaaagaa ctacttggct    120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg    180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc    240

atcaccagtg tgcaggctga ggacctggca gttttttact gcaagcaatc ttataatctt    300

cggacgttcg gtggaggcac caagctggaa atcaaa                              336


<210>  28
<211>  354
<212>  DNA
<213>  mus musculus

<400>  28
gaggtgaagc tggtggagtc tggaggaggc ttggtacagc ctgggggttc tctgagactc     60

tcctgtacaa cttctgggtt caccttcact gattactaca tgagctgggt ccgccagtct    120

ccaggaaagg cacttgagtg gttgactttt attagaaaca aagctaatgg ttacacaaca    180

gagtacagtg catctgtgaa gggtcggttc accatctcca gagataattc ccaaagcatc    240

ctctatcttc aaatgaacac cctgagagct gaggacagtg ccacttatta ctgtgcaaga    300

gatatcccgg ggtttgctta ctggggccaa gggactctgg tcactgtctc tgca          354


<210>  29
<211>  352
<212>  PRT
<213>  Mus musculus

<400>  29

Met Glu Gly Ile Ser Ile Tyr Thr Ser Asp Asn Tyr Thr Glu Glu Met 
1               5                   10                  15      


Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys Phe Arg Glu Glu 
            20                  25                  30          


Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Thr Ile Tyr Ser Ile Ile 
        35                  40                  45              


Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile Leu Val Met Gly 
    50                  55                  60                  


Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr Arg Leu His Leu 
65                  70                  75                  80  


Ser Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro Phe Trp Ala Val 
                85                  90                  95      


Asp Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu Cys Lys Ala Val 
            100                 105                 110         


His Val Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val Leu Ile Leu Ala 
        115                 120                 125             


Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His Ala Thr Asn Ser 
    130                 135                 140                 


Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val Tyr Val Gly Val 
145                 150                 155                 160 


Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe Ile Phe Ala Asn 
                165                 170                 175     


Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg Phe Tyr Pro Asn 
            180                 185                 190         


Asp Leu Trp Val Val Val Phe Gln Phe Gln His Ile Met Val Gly Leu 
        195                 200                 205             


Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys Ile Ile Ile Ser 
    210                 215                 220                 


Lys Leu Ser His Ser Lys Gly His Gln Lys Arg Lys Ala Leu Lys Thr 
225                 230                 235                 240 


Thr Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp Leu Pro Tyr Tyr 
                245                 250                 255     


Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu Ile Ile Lys Gln 
            260                 265                 270         


Gly Cys Glu Phe Glu Asn Thr Val His Lys Trp Ile Ser Ile Thr Glu 
        275                 280                 285             


Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile Leu Tyr Ala Phe 
    290                 295                 300                 


Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala Leu Thr Ser Val 
305                 310                 315                 320 


Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly Lys Arg Gly Gly 
                325                 330                 335     


His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser Phe His Ser Ser 
            340                 345                 350         


<210>  30
<211>  356
<212>  PRT
<213>  Mus musculus

<400>  30

Met Ser Ile Pro Leu Pro Leu Leu Gln Ile Tyr Thr Ser Asp Asn Tyr 
1               5                   10                  15      


Thr Glu Glu Met Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys 
            20                  25                  30          


Phe Arg Glu Glu Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Thr Ile 
        35                  40                  45              


Tyr Ser Ile Ile Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile 
    50                  55                  60                  


Leu Val Met Gly Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr 
65                  70                  75                  80  


Arg Leu His Leu Ser Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro 
                85                  90                  95      


Phe Trp Ala Val Asp Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu 
            100                 105                 110         


Cys Lys Ala Val His Val Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val 
        115                 120                 125             


Leu Ile Leu Ala Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His 
    130                 135                 140                 


Ala Thr Asn Ser Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val 
145                 150                 155                 160 


Tyr Val Gly Val Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe 
                165                 170                 175     


Ile Phe Ala Asn Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg 
            180                 185                 190         


Phe Tyr Pro Asn Asp Leu Trp Val Val Val Phe Gln Phe Gln His Ile 
        195                 200                 205             


Met Val Gly Leu Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys 
    210                 215                 220                 


Ile Ile Ile Ser Lys Leu Ser His Ser Lys Gly His Gln Lys Arg Lys 
225                 230                 235                 240 


Ala Leu Lys Thr Thr Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp 
                245                 250                 255     


Leu Pro Tyr Tyr Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu 
            260                 265                 270         


Ile Ile Lys Gln Gly Cys Glu Phe Glu Asn Thr Val His Lys Trp Ile 
        275                 280                 285             


Ser Ile Thr Glu Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile 
    290                 295                 300                 


Leu Tyr Ala Phe Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala 
305                 310                 315                 320 


Leu Thr Ser Val Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly 
                325                 330                 335     


Lys Arg Gly Gly His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser 
            340                 345                 350         


Phe His Ser Ser 
        355     


<210>  31
<211>  360
<212>  PRT
<213>  Mus musculus

<400>  31

Met Glu Asp Phe Asn Met Glu Ser Asp Ser Phe Glu Asp Phe Trp Lys 
1               5                   10                  15      


Gly Glu Asp Leu Ser Asn Tyr Ser Tyr Ser Ser Thr Leu Pro Pro Phe 
            20                  25                  30          


Leu Leu Asp Ala Ala Pro Cys Glu Pro Glu Ser Leu Glu Ile Asn Lys 
        35                  40                  45              


Tyr Phe Val Val Ile Ile Tyr Ala Leu Val Phe Leu Leu Ser Leu Leu 
    50                  55                  60                  


Gly Asn Ser Leu Val Met Leu Val Ile Leu Tyr Ser Arg Val Gly Arg 
65                  70                  75                  80  


Ser Val Thr Asp Val Tyr Leu Leu Asn Leu Ala Leu Ala Asp Leu Leu 
                85                  90                  95      


Phe Ala Leu Thr Leu Pro Ile Trp Ala Ala Ser Lys Val Asn Gly Trp 
            100                 105                 110         


Ile Phe Gly Thr Phe Leu Cys Lys Val Val Ser Leu Leu Lys Glu Val 
        115                 120                 125             


Asn Phe Tyr Ser Gly Ile Leu Leu Leu Ala Cys Ile Ser Val Asp Arg 
    130                 135                 140                 


Tyr Leu Ala Ile Val His Ala Thr Arg Thr Leu Thr Gln Lys Arg Tyr 
145                 150                 155                 160 


Leu Val Lys Phe Ile Cys Leu Ser Ile Trp Gly Leu Ser Leu Leu Leu 
                165                 170                 175     


Ala Leu Pro Val Leu Leu Phe Arg Arg Thr Val Tyr Ser Ser Asn Val 
            180                 185                 190         


Ser Pro Ala Cys Tyr Glu Asp Met Gly Asn Asn Thr Ala Asn Trp Arg 
        195                 200                 205             


Met Leu Leu Arg Ile Leu Pro Gln Ser Phe Gly Phe Ile Val Pro Leu 
    210                 215                 220                 


Leu Ile Met Leu Phe Cys Tyr Gly Phe Thr Leu Arg Thr Leu Phe Lys 
225                 230                 235                 240 


Ala His Met Gly Gln Lys His Arg Ala Met Arg Val Ile Phe Ala Val 
                245                 250                 255     


Val Leu Ile Phe Leu Leu Cys Trp Leu Pro Tyr Asn Leu Val Leu Leu 
            260                 265                 270         


Ala Asp Thr Leu Met Arg Thr Gln Val Ile Gln Glu Thr Cys Glu Arg 
        275                 280                 285             


Arg Asn His Ile Asp Arg Ala Leu Asp Ala Thr Glu Ile Leu Gly Ile 
    290                 295                 300                 


Leu His Ser Cys Leu Asn Pro Leu Ile Tyr Ala Phe Ile Gly Gln Lys 
305                 310                 315                 320 


Phe Arg His Gly Leu Leu Lys Ile Leu Ala Ile His Gly Leu Ile Ser 
                325                 330                 335     


Lys Asp Ser Leu Pro Lys Asp Ser Arg Pro Ser Phe Val Gly Ser Ser 
            340                 345                 350         


Ser Gly His Thr Ser Thr Thr Leu 
        355                 360 


<210>  32
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  32
gaaactctgc attctcgctt cctg                                            24


<210>  33
<211>  22
<212>  DNA
<213>  Mus musculus

<400>  33
aggactcgtt tgtacccgtt ga                                              22


<210>  34
<211>  26
<212>  DNA
<213>  Mus musculus

<400>  34
tgcagattgg ctacccaact gttgca                                          26


<210>  35
<211>  22
<212>  DNA
<213>  Mus musculus

<400>  35
ctccttcatc ctcctggaaa tc                                              22


<210>  36
<211>  22
<212>  DNA
<213>  Mus musculus

<400>  36
ccaaggaaag catagaggat gg                                              22


<210>  37
<211>  22
<212>  DNA
<213>  Mus musculus

<400>  37
gtggtcatta tctatgccct gg                                              22


<210>  38
<211>  22
<212>  DNA
<213>  Mus musculus

<400>  38
cgaccctgct gtataagatg ac                                              22


<210>  39
<211>  25
<212>  DNA
<213>  Mus musculus

<400>  39
tattcctgct gagcctgctg ggaaa                                           25


<210>  40
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  40

Gln Ser Leu Phe Asn Ser Arg Thr Arg Lys Asn Tyr 
1               5                   10          


<210>  41
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  41

Met Gln Ser Phe Asn Leu Arg Thr 
1               5               


<210>  42
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  42

Asp Asn Tyr 
1           


<210>  43
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  43

Asp Val Gly Ser Asn Tyr Phe Asp Tyr 
1               5                   


<210>  44
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  44

Gly Phe Thr Phe Thr Asp Asn Tyr 
1               5               


<210>  45
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  45

Ala Arg Asp Val Gly Ser Asn Tyr Phe Asp Tyr 
1               5                   10      


<210>  46
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  46

Lys Ser Ser Gln Ser Leu Phe Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  47
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  47

Trp Ala Ser Ala Arg Asp Ser 
1               5           


<210>  48
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  48

Asp Asn Tyr Met Ser 
1               5   


<210>  49
<211>  19
<212>  PRT
<213>  Mus musculus

<400>  49

Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Asp Tyr Ser Ala Ser 
1               5                   10                  15      


Val Arg Gly 
            


<210>  50
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  50

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ala Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Ala Arg Phe Thr Gly Ser Gly Ser Glu Thr Tyr Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Arg Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Ser Phe Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  51
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  51

Glu Val Asn Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Thr Asp Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Gly Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Asp Tyr Ser Ala 
    50                  55                  60                  


Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ala Leu Arg Ala Glu Asp Ser Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Val Gly Ser Asn Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser  
        115                 120



<210>  52
<211>  36
<212>  DNA
<213>  Mus musculus

<400>  52
cagagtctgt tcaacagtcg aacccgaaag aactac                               36


<210>  53
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  53
atgcaatctt ttaatcttcg gacg                                            24


<210>  54
<211>  9
<212>  DNA
<213>  Mus musculus

<400>  54
gataactac                                                              9


<210>  55
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  55
gatgtcggtt ccaactactt tgactac                                         27


<210>  56
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  56
gatgtcggtt ccaactactt tgactac                                         27


<210>  57
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  57
gcaagagatg tcggttccaa ctactttgac tac                                  33


<210>  58
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  58
aaatccagtc agagtctgtt caacagtcga acccgaaaga actacttggc t              51


<210>  59
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  59
tgggcatccg ctagggattc t                                               21


<210>  60
<211>  15
<212>  DNA
<213>  Mus musculus

<400>  60
gataactaca tgagt                                                      15


<210>  61
<211>  57
<212>  DNA
<213>  Mus musculus

<400>  61
tttattagaa acaaagctaa tggttacaca acagactaca gtgcatctgt gaggggt        57


<210>  62
<211>  336
<212>  DNA
<213>  Mus musculus

<400>  62
gacattgtga tgtcacagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact     60

atgagctgca aatccagtca gagtctgttc aacagtcgaa cccgaaagaa ctacttggct    120

tggtaccagc agaagccagg gcagtctcct aaactgctga tctactgggc atccgctagg    180

gattctgggg tccctgctcg cttcacaggc agtggatctg agacatattt cactctcacc    240

atcagccgtg tgcaggctga agacctggca gtttattact gcatgcaatc ttttaatctt    300

cggacgttcg gtggaggcac caagctggaa atcaaa                              336


<210>  63
<211>  360
<212>  DNA
<213>  Mus musculus

<400>  63
gaggtgaacc tggtggagtc tggaggaggc ttggtacagc ctgggggttc tctgagactc     60

tcctgtgcaa cttctgggtt caccttcact gataactaca tgagttgggt ccgccagcct    120

ccaggaaagg cacttgagtg gttgggcttt attagaaaca aagctaatgg ttacacaaca    180

gactacagtg catctgtgag gggtcggttc accatctcaa gagataattc ccaaagcatc    240

ctctatcttc aaatgaacgc cctgagagcc gaagacagtg ccacttatta ctgtgcaaga    300

gatgtcggtt ccaactactt tgactactgg ggccaaggca ccactctcac agtctcctca    360


<210>  64
<211>  239
<212>  PRT
<213>  mus musculus

<400>  64

Met Glu Ser Gln Ala Gln Val Leu Ile Leu Leu Leu Leu Trp Val Ser 
1               5                   10                  15      


Gly Thr Cys Gly Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala 
            20                  25                  30          


Val Ser Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Tyr Asn Ser Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Thr Ser Val Gln Ala Glu Asp Leu Ala Val Phe 
            100                 105                 110         


Tyr Cys Lys Gln Ser Tyr Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  65
<211>  467
<212>  PRT
<213>  mus musculus

<400>  65

Met Lys Leu Trp Leu Asn Trp Val Phe Leu Val Thr Leu Leu Asn Gly 
1               5                   10                  15      


Phe Gln Cys Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Thr Ser Gly Phe Thr Phe 
        35                  40                  45              


Thr Asp Tyr Tyr Met Ser Trp Val Arg Gln Ser Pro Gly Lys Ala Leu 
    50                  55                  60                  


Glu Trp Leu Thr Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu 
65                  70                  75                  80  


Tyr Ser Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Gln Ser Ile Leu Tyr Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Ser 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Ala Arg Asp Ile Pro Gly Phe Ala Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  66
<211>  239
<212>  PRT
<213>  mus musculus

<400>  66

Met Glu Ser Gln Thr Leu Val Phe Ile Ser Ile Leu Leu Trp Leu Tyr 
1               5                   10                  15      


Gly Thr Cys Gly Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala 
            20                  25                  30          


Val Ser Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Phe Asn Ser Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ala Arg 
65                  70                  75                  80  


Asp Ser Gly Val Pro Ala Arg Phe Thr Gly Ser Gly Ser Glu Thr Tyr 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Arg Val Gln Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys Met Gln Ser Phe Asn Leu Arg Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  67
<211>  469
<212>  PRT
<213>  mus musculus

<400>  67

Met Lys Met Trp Leu Asn Trp Val Phe Leu Val Thr Leu Leu Asn Gly 
1               5                   10                  15      


Ile Gln Cys Glu Val Asn Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe 
        35                  40                  45              


Thr Asp Asn Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys Ala Leu 
    50                  55                  60                  


Glu Trp Leu Gly Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Asp 
65                  70                  75                  80  


Tyr Ser Ala Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Gln Ser Ile Leu Tyr Leu Gln Met Asn Ala Leu Arg Ala Glu Asp Ser 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Ala Arg Asp Val Gly Ser Asn Tyr Phe Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    210                 215                 220                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
225                 230                 235                 240 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly Lys 
465                 


<210>  68
<211>  720
<212>  DNA
<213>  mus musculus

<400>  68
atggagtcac aggcccaggt tcttatattg ctgctgctat gggtatctgg tacctgtggg     60

gacattgtga tgtcacagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact    120

atgagctgca aatccagtca gagtctgtac aacagtagaa cccgaaagaa ctacttggct    180

tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg    240

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc    300

atcaccagtg tgcaggctga ggacctggca gttttttact gcaagcaatc ttataatctt    360

cggacgttcg gtggaggcac caagctggaa atcaaacgta cggtggccgc tcccagcgtg    420

ttcatcttcc ccccaagcga cgagcagctg aagagcggca ccgccagcgt ggtgtgtctg    480

ctgaacaact tctaccccag ggaggccaag gtgcagtgga aggtggacaa cgccctgcag    540

agcggcaaca gccaggagag cgtcaccgag caggacagca aggactccac ctacagcctg    600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgtgag    660

gtgacccacc agggcctgtc cagccccgtg accaagagct tcaacagggg cgagtgctga    720


<210>  69
<211>  1404
<212>  DNA
<213>  mus musculus

<400>  69
atgaagctgt ggctgaactg ggtgttcctg gtgaccctgc tgaacggctt ccagtgcgaa     60

gtgaaactgg tggagtctgg cggcggactg gtgcagccag gcggcagcct gagactgagc    120

tgcaccacct ccggcttcac cttcaccgac tactacatga gctgggtgcg ccagagcccc    180

ggcaaggccc tggaatggct gaccttcatc cggaacaagg ccaacggcta caccaccgag    240

tacagcgcca gcgtgaaggg ccggttcacc atcagccggg acaacagcca gagcatcctg    300

tacctgcaga tgaacaccct gcgggccgag gactccgcca cctactactg cgccagagac    360

atccccggct tcgcctactg gggccagggc accctggtga ccgtgtccgc cgccagcacc    420

aagggcccaa gcgtgttccc gctagccccc agcagcaaga gcaccagcgg cggcacagcc    480

gccctgggct gcctggtgaa ggactacttc cccgagcccg tgaccgtgtc ctggaacagc    540

ggagccctga cctccggcgt gcacaccttc cccgccgtgc tgcagagcag cggcctgtac    600

agcctgagca gcgtggtgac cgtgcccagc agcagcctgg gcacccagac ctacatctgt    660

aacgtgaacc acaagcccag caacaccaag gtggacaaga gagtggagcc caagagctgt    720

gacaagaccc acacctgccc cccctgccca gcccccgagc tgctgggcgg acccagcgtg    780

ttcctgttcc cccccaagcc caaggacacc ctgatgatca gcagaacccc cgaggtgacc    840

tgtgtggtgg tggacgtgtc ccacgaggac ccagaggtga agttcaactg gtacgtggac    900

ggcgtggagg tgcacaacgc caagaccaag cccagagagg agcagtacaa cagcacctac    960

agggtggtgt ccgtgctgac cgtgctgcac caggactggc tgaacggcaa ggagtacaag   1020

tgtaaggtgt ccaacaaggc cctgccagcc ccaatcgaaa agaccatcag caaggccaag   1080

ggccagccaa gagagcccca ggtgtacacc ctgccaccca gcagggagga gatgaccaag   1140

aaccaggtgt ccctgacctg tctggtgaag ggcttctacc caagcgacat cgccgtggag   1200

tgggagagca acggccagcc cgagaacaac tacaagacca cccccccagt gctggacagc   1260

gacggcagct tcttcctgta cagcaagctg accgtggaca agagcagatg gcagcagggc   1320

aacgtgttca gctgctccgt gatgcacgag gccctgcaca accactacac ccagaagagc   1380

ctgagcctgt ccccaggcaa gtga                                          1404


<210>  70
<211>  720
<212>  DNA
<213>  mus musculus

<400>  70
atggagtcac agactctggt cttcatatcc atactgctct ggttatatgg tacctgtggg     60

gacattgtga tgtcacagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact    120

atgagctgca aatccagtca gagtctgttc aacagtcgaa cccgaaagaa ctacttggct    180

tggtaccagc agaagccagg gcagtctcct aaactgctga tctactgggc atccgctagg    240

gattctgggg tccctgctcg cttcacaggc agtggatctg agacatattt cactctcacc    300

atcagccgtg tgcaggctga agacctggca gtttattact gcatgcaatc ttttaatctt    360

cggacgttcg gtggaggcac caagctggaa atcaaacgta cggtggccgc tcccagcgtg    420

ttcatcttcc ccccaagcga cgagcagctg aagagcggca ccgccagcgt ggtgtgtctg    480

ctgaacaact tctaccccag ggaggccaag gtgcagtgga aggtggacaa cgccctgcag    540

agcggcaaca gccaggagag cgtcaccgag caggacagca aggactccac ctacagcctg    600

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgtgag    660

gtgacccacc agggcctgtc cagccccgtg accaagagct tcaacagggg cgagtgctga    720


<210>  71
<211>  1410
<212>  DNA
<213>  mus musculus

<400>  71
atgaagatgt ggctgaactg ggtgttcctg gtgaccctgc tgaacggcat ccagtgcgaa     60

gtgaacctgg tggagtctgg cggcggactg gtgcagcctg ggggcagcct gagactgagc    120

tgcgccacct ccggcttcac cttcaccgac aactacatga gctgggtgcg ccagccccct    180

ggcaaggccc tggaatggct gggcttcatc cggaacaagg ccaacggcta caccaccgac    240

tacagcgcca gcgtgcgggg cagattcacc atcagccggg acaacagcca gagcatcctg    300

tacctgcaga tgaacgccct gcgggccgag gacagcgcca cctactactg tgcccgggac    360

gtgggcagca actacttcga ctactggggc cagggcacca cactgaccgt gtccagcgcc    420

agcaccaagg gcccctccgt gttcccgcta gcccccagca gcaagagcac cagcggcggc    480

acagccgccc tgggctgcct ggtgaaggac tacttccccg agcccgtgac cgtgtcctgg    540

aacagcggag ccctgacctc cggcgtgcac accttccccg ccgtgctgca gagcagcggc    600

ctgtacagcc tgagcagcgt ggtgaccgtg cccagcagca gcctgggcac ccagacctac    660

atctgtaacg tgaaccacaa gcccagcaac accaaggtgg acaagagagt ggagcccaag    720

agctgtgaca agacccacac ctgccccccc tgcccagccc ccgagctgct gggcggaccc    780

agcgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagcag aacccccgag    840

gtgacctgtg tggtggtgga cgtgtcccac gaggacccag aggtgaagtt caactggtac    900

gtggacggcg tggaggtgca caacgccaag accaagccca gagaggagca gtacaacagc    960

acctacaggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggag   1020

tacaagtgta aggtgtccaa caaggccctg ccagccccaa tcgaaaagac catcagcaag   1080

gccaagggcc agccaagaga gccccaggtg tacaccctgc cacccagcag ggaggagatg   1140

accaagaacc aggtgtccct gacctgtctg gtgaagggct tctacccaag cgacatcgcc   1200

gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc cccagtgctg   1260

gacagcgacg gcagcttctt cctgtacagc aagctgaccg tggacaagag cagatggcag   1320

cagggcaacg tgttcagctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag   1380

aagagcctga gcctgtcccc aggcaagtga                                    1410

