                         SEQUENCE LISTING

<110>  Baker, James R. Jr.
       Hemmila, Mark R.
       Wang, Stewart C.
       Hamouda, Tarek
       LiPuma, John J.
       Knowlton, Jessica Ann
       Makidon, Paul E.
       Blanco, Luz
       Groom II, Jeffery V.
       Bielinska, Anna U.

 
<120>  Nanoemulsion Therapeutic Compositions and Methods of Using the 
       Same

<130>  UM-30648/WO-1/ORD

<150>  US 61/100,559
<151>  2008-09-26

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  142
<212>  PRT
<213>  Burkholderia cenocepacia

<400>  1

Leu Asp Asp Lys Ala Asn Ala Gly Ala Val Ser Thr Gln Pro Ser Ala 
1               5                   10                  15      


Asp Asn Val Ala Gln Val Asn Val Asp Pro Leu Asn Asp Pro Asn Ser 
            20                  25                  30          


Pro Leu Ala Lys Arg Ser Ile Tyr Phe Asp Phe Asp Ser Tyr Ser Val 
        35                  40                  45              


Lys Asp Glu Tyr Gln Pro Leu Leu Gln Gln His Ala Gln Tyr Leu Lys 
    50                  55                  60                  


Ser His Pro Gln Arg His Val Leu Ile Gln Gly Asn Thr Asp Glu Arg 
65                  70                  75                  80  


Gly Thr Ser Glu Tyr Asn Leu Ala Leu Gly Gln Lys Arg Ala Glu Ala 
                85                  90                  95      


Val Arg Arg Ala Leu Ala Leu Leu Gly Val Ala Asp Ser Gln Met Glu 
            100                 105                 110         


Ala Val Ser Leu Gly Lys Glu Lys Pro Leu Ala Thr Gly His Asp Ala 
        115                 120                 125             


Ser Trp Ala Gln Asn Arg Arg Ala Asp Leu Val Tyr Gln Gln 
    130                 135                 140         


<210>  2
<211>  142
<212>  PRT
<213>  Burkholderia dolosa

<400>  2

Leu Asp Asp Lys Ala Asn Ala Gly Ala Val Ser Thr Gln Pro Ser Ala 
1               5                   10                  15      


Asp Asn Val Ala Gln Val Asn Val Asp Pro Leu Asn Asp Pro Asn Ser 
            20                  25                  30          


Pro Leu Ala Lys Arg Ser Ile Tyr Phe Asp Phe Asp Ser Tyr Ser Val 
        35                  40                  45              


Lys Asp Glu Tyr Gln Pro Leu Leu Gln Gln His Ala Gln Tyr Leu Lys 
    50                  55                  60                  


Ser His Pro Gln Arg His Val Leu Ile Gln Gly Asn Thr Asp Glu Arg 
65                  70                  75                  80  


Gly Thr Ser Glu Tyr Asn Leu Ala Leu Gly Gln Lys Arg Ala Glu Ala 
                85                  90                  95      


Val Arg Arg Ala Leu Ala Leu Leu Gly Val Ala Asp Ser Gln Met Glu 
            100                 105                 110         


Ala Val Ser Leu Gly Lys Glu Lys Pro Leu Ala Thr Gly His Asp Ala 
        115                 120                 125             


Ser Trp Ala Gln Asn Arg Arg Ala Asp Leu Val Tyr Gln Gln 
    130                 135                 140         


<210>  3
<211>  141
<212>  PRT
<213>  Burkholderia multivorans

<400>  3

Leu Asp Asp Lys Ala Asn Ala Gly Ala Ser Thr Gln Pro Ser Ala Asp 
1               5                   10                  15      


Asn Val Ala Gln Val Asn Val Asp Pro Leu Asn Asp Pro Asn Ser Pro 
            20                  25                  30          


Leu Ala Lys Arg Ser Ile Tyr Phe Asp Phe Asp Ser Tyr Ser Val Lys 
        35                  40                  45              


Asp Glu Tyr Gln Pro Leu Leu Gln Gln His Ala Gln Tyr Leu Lys Ser 
    50                  55                  60                  


His Pro Gln Arg His Val Leu Ile Gln Gly Asn Thr Asp Glu Arg Gly 
65                  70                  75                  80  


Thr Ser Glu Tyr Asn Leu Ala Leu Gly Gln Lys Arg Ala Glu Ala Val 
                85                  90                  95      


Arg Arg Ala Leu Ala Leu Leu Gly Val Ala Asp Ser Gln Met Glu Ala 
            100                 105                 110         


Val Ser Leu Gly Lys Glu Lys Pro Ala Thr Gly His Asp Glu Ala Ser 
        115                 120                 125             


Trp Ala Gln Asn Arg Arg Ala Asp Leu Val Tyr Gln Gln 
    130                 135                 140     


<210>  4
<211>  138
<212>  PRT
<213>  Burkholderia ambifaria

<400>  4

Leu Asp Asp Lys Ala Asn Ala Gly Ala Val Ser Thr Gln Pro Ser Ala 
1               5                   10                  15      


Asp Asn Val Ala Gln Val Asn Val Asp Pro Leu Asn Asp Pro Asn Ser 
            20                  25                  30          


Pro Leu Ala Lys Arg Ser Ile Tyr Phe Asp Phe Asp Ser Tyr Ser Val 
        35                  40                  45              


Lys Asp Glu Tyr Gln Pro Leu Gln Gln His Ala Gln Tyr Leu Lys Ser 
    50                  55                  60                  


His Pro Gln Arg His Val Leu Ile Gln Gly Asn Thr Asp Glu Arg Gly 
65                  70                  75                  80  


Thr Ser Glu Tyr Asn Leu Ala Leu Gly Gln Lys Arg Ala Glu Ala Val 
                85                  90                  95      


Arg Arg Ala Ala Leu Leu Gly Val Asp Ser Gln Met Glu Ala Val Ser 
            100                 105                 110         


Leu Gly Lys Glu Lys Pro Ala Gly His Asp Glu Ala Ser Trp Ala Gln 
        115                 120                 125             


Asn Arg Arg Ala Asp Leu Val Tyr Gln Gln 
    130                 135             


<210>  5
<211>  140
<212>  PRT
<213>  Burkholderia vietnamiensis

<400>  5

Leu Asp Asp Lys Ala Asn Ala Gly Ala Val Ser Thr Gln Pro Ser Ala 
1               5                   10                  15      


Asp Asn Val Ala Gln Val Asn Val Asp Pro Leu Asn Asp Pro Asn Ser 
            20                  25                  30          


Pro Leu Ala Lys Arg Ser Ile Tyr Phe Asp Phe Asp Ser Tyr Ser Val 
        35                  40                  45              


Lys Asp Glu Tyr Gln Pro Leu Leu Gln Gln His Ala Gln Tyr Leu Lys 
    50                  55                  60                  


Ser His Pro Gln Arg His Val Leu Ile Gln Gly Asn Thr Asp Glu Arg 
65                  70                  75                  80  


Gly Thr Ser Glu Tyr Asn Leu Ala Leu Gly Gln Lys Arg Ala Glu Ala 
                85                  90                  95      


Val Arg Arg Ala Ala Leu Leu Gly Val Asp Ser Gln Met Glu Ala Val 
            100                 105                 110         


Ser Leu Gly Lys Glu Lys Pro Ala Thr Gly His Asp Glu Ala Ser Trp 
        115                 120                 125             


Ala Gln Asn Arg Arg Ala Asp Leu Val Tyr Gln Gln 
    130                 135                 140 


<210>  6
<211>  132
<212>  PRT
<213>  Burkholderia ubonensis

<400>  6

Leu Asp Lys Ala Asn Ala Gly Ala Ser Thr Gln Pro Asn Val Ala Gln 
1               5                   10                  15      


Val Val Asp Pro Leu Asn Asp Pro Asn Ser Pro Leu Ala Lys Arg Ser 
            20                  25                  30          


Ile Tyr Phe Asp Phe Asp Ser Tyr Ser Val Lys Asp Glu Tyr Gln Pro 
        35                  40                  45              


Leu Gln Gln His Ala Gln Tyr Leu Lys Ser His Pro Gln Arg His Val 
    50                  55                  60                  


Leu Ile Gln Gly Asn Thr Asp Glu Arg Gly Thr Ser Glu Tyr Asn Leu 
65                  70                  75                  80  


Ala Leu Gly Gln Lys Arg Ala Glu Ala Val Arg Arg Ala Ala Leu Leu 
                85                  90                  95      


Gly Val Ala Asp Ser Gln Met Glu Ala Val Ser Leu Gly Lys Glu Lys 
            100                 105                 110         


Pro Ala Gly His Asp Glu Ala Ser Trp Ala Gln Asn Arg Arg Asp Leu 
        115                 120                 125             


Val Tyr Gln Gln 
    130         


<210>  7
<211>  127
<212>  PRT
<213>  Burkholderia thailandensis

<400>  7

Leu Asp Ala Asn Gly Ala Val Ser Thr Gln Pro Asn Ala Gln Val Val 
1               5                   10                  15      


Asp Pro Leu Asn Asp Pro Asn Ser Pro Leu Ala Lys Arg Ser Tyr Phe 
            20                  25                  30          


Asp Phe Asp Ser Tyr Ser Val Asp Tyr Gln Pro Leu Leu Gln Gln His 
        35                  40                  45              


Ala Gln Tyr Leu Lys Ser His Pro Gln Arg His Leu Ile Gln Gly Asn 
    50                  55                  60                  


Thr Asp Glu Arg Gly Thr Ser Glu Tyr Asn Leu Ala Leu Gly Gln Lys 
65                  70                  75                  80  


Arg Ala Glu Ala Val Arg Arg Ala Leu Leu Leu Gly Val Asp Ser Gln 
                85                  90                  95      


Met Glu Ala Val Ser Leu Gly Lys Glu Lys Pro Ala Gly His Asp Glu 
            100                 105                 110         


Ala Ser Trp Ala Gln Asn Arg Arg Ala Asp Leu Val Tyr Gln Gln 
        115                 120                 125         


<210>  8
<211>  127
<212>  PRT
<213>  Burkholderia graminis

<400>  8

Leu Asp Ala Asn Gly Ala Val Ser Thr Gln Pro Val Ala Gln Val Asn 
1               5                   10                  15      


Val Asp Pro Leu Asn Asp Pro Asn Ser Pro Leu Ala Lys Arg Ser Ile 
            20                  25                  30          


Tyr Phe Asp Phe Asp Ser Tyr Ser Val Lys Asp Tyr Gln Leu Leu Gln 
        35                  40                  45              


Gln His Gln Tyr Leu Lys Ser His Pro Gln Arg His Val Leu Ile Gln 
    50                  55                  60                  


Gly Asn Thr Asp Glu Arg Gly Thr Ser Glu Tyr Asn Leu Ala Leu Gly 
65                  70                  75                  80  


Gln Lys Arg Ala Glu Ala Val Arg Arg Leu Leu Gly Val Asp Ser Gln 
                85                  90                  95      


Met Glu Ala Val Ser Leu Gly Lys Glu Lys Pro Ala Thr Gly His Asp 
            100                 105                 110         


Glu Ser Trp Ala Gln Asn Arg Arg Ala Asp Leu Val Tyr Gln Gln 
        115                 120                 125         


<210>  9
<211>  126
<212>  PRT
<213>  Burkholderia oklahomensis

<400>  9

Leu Asp Ala Asn Gly Ala Val Ser Thr Gln Pro Asn Val Ala Gln Val 
1               5                   10                  15      


Val Asp Pro Leu Asn Asp Pro Asn Ser Pro Leu Ala Lys Arg Ser Tyr 
            20                  25                  30          


Phe Asp Phe Asp Ser Tyr Ser Val Asp Tyr Gln Leu Leu Gln Gln His 
        35                  40                  45              


Ala Gln Tyr Leu Lys His Pro Gln Arg His Leu Ile Gln Gly Asn Thr 
    50                  55                  60                  


Asp Glu Arg Gly Thr Ser Glu Tyr Asn Leu Ala Leu Gly Gln Lys Arg 
65                  70                  75                  80  


Ala Glu Ala Val Arg Arg Ala Leu Leu Leu Gly Val Asp Ser Gln Met 
                85                  90                  95      


Glu Ala Val Ser Leu Gly Lys Glu Lys Pro Ala Gly His Asp Glu Ala 
            100                 105                 110         


Ser Trp Ala Gln Asn Arg Arg Ala Asp Leu Val Tyr Gln Gln 
        115                 120                 125     


<210>  10
<211>  126
<212>  PRT
<213>  Burkholderia pseudomallei

<400>  10

Leu Asp Ala Asn Gly Ala Val Ser Thr Gln Pro Asn Val Ala Gln Val 
1               5                   10                  15      


Val Asp Pro Leu Asn Asp Pro Asn Ser Pro Leu Ala Lys Arg Ser Tyr 
            20                  25                  30          


Phe Asp Phe Asp Ser Tyr Ser Val Asp Tyr Gln Leu Leu Gln Gln His 
        35                  40                  45              


Ala Gln Tyr Leu Lys Ser His Pro Gln Arg His Leu Ile Gln Gly Asn 
    50                  55                  60                  


Thr Asp Glu Arg Gly Thr Ser Glu Tyr Asn Leu Ala Leu Gly Gln Lys 
65                  70                  75                  80  


Arg Ala Glu Ala Val Arg Arg Ala Leu Leu Leu Gly Val Asp Gln Met 
                85                  90                  95      


Glu Ala Val Ser Leu Gly Lys Glu Lys Pro Ala Gly His Asp Glu Ala 
            100                 105                 110         


Ser Trp Ala Gln Asn Arg Arg Ala Asp Leu Val Tyr Gln Gln 
        115                 120                 125     


<210>  11
<211>  123
<212>  PRT
<213>  Burkholderia xenovorans

<400>  11

Leu Asp Ala Asn Gly Val Ser Gln Pro Val Ala Val Val Asp Pro Leu 
1               5                   10                  15      


Asn Asp Pro Asn Ser Pro Leu Ala Lys Arg Ser Ile Tyr Phe Asp Phe 
            20                  25                  30          


Asp Ser Tyr Ser Val Lys Asp Tyr Gln Leu Leu Gln Gln His Ala Gln 
        35                  40                  45              


Tyr Leu Lys Ser His Pro Gln Arg His Leu Ile Gln Gly Asn Thr Asp 
    50                  55                  60                  


Glu Arg Gly Thr Ser Glu Tyr Asn Leu Ala Leu Gly Gln Lys Arg Ala 
65                  70                  75                  80  


Glu Ala Val Arg Arg Leu Leu Gly Val Asp Ser Gln Met Glu Ala Val 
                85                  90                  95      


Ser Leu Gly Lys Glu Lys Pro Ala Thr Gly His Asp Glu Ser Trp Ala 
            100                 105                 110         


Gln Asn Arg Arg Ala Asp Leu Val Tyr Gln Gln 
        115                 120             


<210>  12
<211>  125
<212>  PRT
<213>  Burkholderia phytofirmans

<400>  12

Leu Asp Ala Asn Gly Val Ser Gln Pro Val Ala Val Asn Val Asp Pro 
1               5                   10                  15      


Leu Asn Asp Pro Asn Ser Pro Leu Ala Lys Arg Ser Ile Tyr Phe Asp 
            20                  25                  30          


Phe Asp Ser Tyr Ser Val Lys Asp Tyr Gln Leu Leu Gln Gln His Ala 
        35                  40                  45              


Gln Tyr Leu Lys Ser His Pro Gln Arg His Val Leu Ile Gln Gly Asn 
    50                  55                  60                  


Thr Asp Glu Arg Gly Thr Ser Glu Tyr Asn Leu Ala Leu Gly Gln Lys 
65                  70                  75                  80  


Arg Ala Glu Ala Val Arg Arg Leu Leu Gly Val Asp Ser Gln Met Glu 
                85                  90                  95      


Ala Val Ser Leu Gly Lys Glu Lys Pro Ala Thr Gly His Asp Glu Ser 
            100                 105                 110         


Trp Ala Gln Asn Arg Arg Ala Asp Leu Val Tyr Gln Gln 
        115                 120                 125 


<210>  13
<211>  125
<212>  PRT
<213>  Burkholderia phymatum

<400>  13

Leu Asp Ala Gly Ala Gln Pro Val Ala Val Asn Val Asp Pro Leu Asn 
1               5                   10                  15      


Asp Pro Asn Ser Pro Leu Ala Lys Arg Ser Ile Tyr Phe Asp Phe Asp 
            20                  25                  30          


Ser Tyr Ser Val Lys Asp Tyr Gln Pro Leu Leu Gln Gln His Ala Gln 
        35                  40                  45              


Tyr Leu Lys Ser His Pro Gln Arg His Val Leu Ile Gln Gly Asn Thr 
    50                  55                  60                  


Asp Glu Arg Gly Thr Ser Glu Tyr Asn Leu Ala Leu Gly Gln Lys Arg 
65                  70                  75                  80  


Ala Glu Ala Val Arg Arg Leu Leu Leu Gly Val Asp Ser Met Glu Ala 
                85                  90                  95      


Val Ser Leu Gly Lys Glu Lys Pro Ala Thr Gly His Asp Glu Ala Ser 
            100                 105                 110         


Trp Ala Gln Asn Arg Arg Ala Asp Leu Val Tyr Gln Gln 
        115                 120                 125 


<210>  14
<211>  106
<212>  PRT
<213>  Ralstonia metallidurans

<400>  14

Leu Asp Asp Gly Ala Ala Asn Val Ala Val Val Asp Pro Leu Asn Asp 
1               5                   10                  15      


Pro Asn Pro Leu Ala Lys Arg Ser Tyr Phe Asp Phe Asp Ser Tyr Ser 
            20                  25                  30          


Val Lys Tyr Gln Leu Gln His Gln Tyr Leu Ser Arg Leu Ile Gln Gly 
        35                  40                  45              


Asn Thr Asp Glu Arg Gly Thr Ser Glu Tyr Asn Leu Ala Leu Gly Gln 
    50                  55                  60                  


Lys Arg Ala Glu Ala Val Arg Arg Leu Ala Gly Val Asp Ser Gln Met 
65                  70                  75                  80  


Glu Ala Val Ser Leu Gly Lys Glu Lys Pro Ala Thr Gly His Asp Ala 
                85                  90                  95      


Ser Trp Ala Asn Arg Arg Ala Asp Val Tyr 
            100                 105     


<210>  15
<211>  107
<212>  PRT
<213>  Ralstonia eutropha

<400>  15

Leu Asp Asp Ala Asn Ala Gly Ala Ala Asp Val Val Val Asp Pro Leu 
1               5                   10                  15      


Asn Asp Pro Asn Ser Pro Leu Ala Lys Arg Ser Tyr Phe Asp Phe Asp 
            20                  25                  30          


Ser Tyr Ser Val Lys Glu Tyr Gln Leu His Ala Tyr Leu Ser Arg Leu 
        35                  40                  45              


Ile Gln Gly Asn Thr Asp Glu Arg Gly Thr Ser Glu Tyr Asn Leu Ala 
    50                  55                  60                  


Leu Gly Gln Lys Arg Ala Glu Ala Val Arg Arg Leu Ala Gly Val Asp 
65                  70                  75                  80  


Ser Gln Met Glu Ala Val Ser Leu Gly Lys Glu Lys Pro Thr Gly His 
                85                  90                  95      


Asp Glu Ala Trp Ala Asn Arg Arg Ala Asp Tyr 
            100                 105         


<210>  16
<211>  108
<212>  PRT
<213>  Ralstonia solanacearum

<400>  16

Leu Asp Asp Lys Gly Thr Asn Val Val Val Asp Leu Asp Pro Asn Ser 
1               5                   10                  15      


Pro Leu Ala Lys Arg Ser Tyr Phe Asp Phe Asp Ser Tyr Val Lys Glu 
            20                  25                  30          


Tyr Gln Leu Leu Gln His Ala Tyr Leu Ser His Gln Arg Val Leu Ile 
        35                  40                  45              


Gln Gly Asn Thr Asp Glu Arg Gly Thr Ser Glu Tyr Asn Leu Ala Leu 
    50                  55                  60                  


Gly Gln Lys Arg Ala Glu Ala Val Arg Arg Ala Leu Gly Val Asp Ser 
65                  70                  75                  80  


Gln Met Glu Ala Val Ser Leu Gly Lys Glu Lys Pro Ala Thr Gly His 
                85                  90                  95      


Asp Glu Ser Trp Ala Gln Asn Arg Arg Asp Val Tyr 
            100                 105             


