                         SEQUENCE LISTING

<110>  The Administrators of the Tulane Educational Fund
 
<120>  THE USE OF PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE 
       (PACAP) AND PACAP ANALOGS AS ADJUNCTIVE TREATMENTS WITH 
       ANTICANCER AGENTS

<130>  07005/011WO2

<160>  70    

<170>  PatentIn version 3.5

<210>  1
<211>  38
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Sequence has an amidated C-terminus

<400>  1

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  2
<211>  27
<212>  PRT
<213>  Homo Sapiens

<220>
<223>  Sequence has an amidated C-terminus

<400>  2

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu 
            20                  25          


<210>  3
<211>  28
<212>  PRT
<213>  Homo Sapiens

<220>
<223>  Sequence has an amidated C-terminus

<400>  3

His Ser Asp Ala Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn 
            20                  25              


<210>  4
<211>  38
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Serine

<400>  4

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  5
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  2-Aminoisobutyric acid

<400>  5

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Glu 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  6
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Serine

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  N-epsilon-palmitoyl-Lys

<400>  6

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Thr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  7
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  2-Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  N-epsilon-palmitoyl-Lys

<400>  7

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Leu 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  8
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus

<400>  8

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Ala Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  9
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  D-Lysine

<400>  9

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Ala 
1               5                   10                  15      


Ala Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Xaa 
        35              


<210>  10
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus

<400>  10

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Lys Val Lys Asn Lys 
        35              


<210>  11
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  N-epsilon-palmitoyl-Lys

<400>  11

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  12
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Serine

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  D-Lysine

<400>  12

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Ala 
1               5                   10                  15      


Ala Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Xaa 
        35              


<210>  13
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  2-Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  D-Lysine

<400>  13

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Ala 
1               5                   10                  15      


Ala Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Xaa 
        35              


<210>  14
<211>  38
<212>  PRT
<213>  Artificial Sequenec

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Alanine

<400>  14

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  15
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Serine

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Norleucine

<400>  15

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Xaa Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  16
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  2-Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Norleucine

<400>  16

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Xaa Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  17
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Alanine

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Norleucine

<400>  17

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Xaa Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  18
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Serine

<400>  18

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Ala Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  19
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  2-Aminoisobutyric acid

<400>  19

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Ala Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  20
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Alanine

<400>  20

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Ala Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  21
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  N-epsilon-palmitoyl-Lys

<400>  21

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  22
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  N-epsilon-palmitoyl-Lys

<400>  22

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  23
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  N-epsilon-palmitoyl-Lys

<400>  23

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  24
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has a amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Serine

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  N-epsilon-palmitoyl-Lys

<400>  24

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  25
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Serine

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  N-epsilon-palmitoyl-Lys

<400>  25

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  26
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Serine

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  N-epsilon-palmitoyl-Lys

<400>  26

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Glu Arg Val Lys Asn Lys 
        35              


<210>  27
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  2-Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  N-epsilon-palmitoyl-Lys

<400>  27

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  28
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  2-Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  N-epsilon-palmitoyl-Lys

<400>  28

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gly Arg Val Lys Asn Lys 
        35              


<210>  29
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  2-Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  N-epsilon-palmitoyl-Lys

<400>  29

His Xaa Ser Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  30
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus

<400>  30

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Ala Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  31
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus

<400>  31

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Ala Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  32
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus

<400>  32

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Ala Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  33
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Serine

<400>  33

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Ala Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  34
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Serine

<400>  34

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Ala Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  35
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Serine

<400>  35

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Ala Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  36
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus

<400>  36

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Ala Lys Gln 
1               5                   10                  15      


Met Ala Val Ala Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  37
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Serine

<400>  37

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu 
            20                  25          


<210>  38
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  2-Aminoisobutyric acid

<400>  38

His Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln Met 
1               5                   10                  15      


Ala Val Lys Lys Tyr Leu Ala Ala Val Leu 
            20                  25      


<210>  39
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus

<400>  39

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Ala Leu Ala Ala Val Leu 
            20                  25          


<210>  40
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Alanine

<400>  40

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Ala Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu 
            20                  25          


<210>  41
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Serine

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Norleucine

<400>  41

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Xaa Ala Val Lys Lys Tyr Leu Ala Ala Val Leu 
            20                  25          


<210>  42
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  2-Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Norleucine

<400>  42

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Val Arg Lys Gln 
1               5                   10                  15      


Xaa Ala Val Lys Lys Tyr Leu Ala Ala Val Leu 
            20                  25          


<210>  43
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Alanine

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Norleucine

<400>  43

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Xaa Ala Val Lys Lys Tyr Leu Ala Ala Val Leu 
            20                  25          


<210>  44
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Serine

<400>  44

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Ala Ala Val Lys Lys Tyr Leu Ala Ala Val Leu 
            20                  25          


<210>  45
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  2-Aminoisobutyric acid

<400>  45

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Ala Ala Val Lys Lys Tyr Leu Ala Ala Val Leu 
            20                  25          


<210>  46
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Alanine

<400>  46

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Ala Ala Val Lys Lys Tyr Leu Ala Ala Val Leu 
            20                  25          


<210>  47
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Serine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  D-Leucine

<400>  47

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Xaa 
            20                  25          


<210>  48
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  2-Aminoisobutyric acid

<400>  48

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu 
            20                  25          


<210>  49
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus

<400>  49

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Ala Leu Ala Ala Val Leu 
            20                  25          


<210>  50
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  D-Leucine

<400>  50

His Ala Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Xaa 
            20                  25          


<210>  51
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Serine

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Norleucine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  D-Leucine

<400>  51

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Xaa Ala Val Lys Lys Tyr Leu Ala Ala Val Xaa 
            20                  25          


<210>  52
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  2-Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Norleucine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  D-Leucine

<400>  52

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Xaa Ala Val Lys Lys Tyr Leu Ala Ala Val Xaa 
            20                  25          


<210>  53
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Alanine

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Norleucine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  D-Leucine

<400>  53

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Xaa Ala Val Lys Lys Tyr Leu Ala Ala Val Xaa 
            20                  25          


<210>  54
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Serine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  D-Leucine

<400>  54

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Ala Ala Val Lys Lys Tyr Leu Ala Ala Val Xaa 
            20                  25          


<210>  55
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  2-Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  D-Leucine

<400>  55

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Ala Ala Val Lys Lys Tyr Leu Ala Ala Val Xaa 
            20                  25          


<210>  56
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Alanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  D-Leucine

<400>  56

His Xaa Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Ala Ala Val Lys Lys Tyr Leu Ala Ala Val Xaa 
            20                  25          


<210>  57
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Serine

<400>  57

His Xaa Asp Ala Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn 
            20                  25              


<210>  58
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  2-Aminoisobutyric acid

<400>  58

His Xaa Asp Ala Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn 
            20                  25              


<210>  59
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus

<400>  59

His Ser Asp Ala Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Ala Leu Asn Ser Ile Leu Asn 
            20                  25              


<210>  60
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Alanine

<400>  60

His Xaa Asp Ala Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn 
            20                  25              


<210>  61
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Serine

<400>  61

His Xaa Asp Ala Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn 
            20                  25          


<210>  62
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  2-Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Norleucine

<400>  62

His Xaa Asp Ala Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Xaa Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn 
            20                  25              


<210>  63
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Alanine

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Norleucine

<400>  63

His Xaa Asp Ala Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Xaa Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn 
            20                  25              


<210>  64
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Serine

<400>  64

His Xaa Asp Ala Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Ala Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn 
            20                  25              


<210>  65
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  2-Aminoisobutyric acid

<400>  65

His Xaa Asp Ala Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Ala Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn 
            20                  25              


<210>  66
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Alanine

<400>  66

His Xaa Asp Ala Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Asn 
1               5                   10                  15      


Ala Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn 
            20                  25              


<210>  67
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sequence has an amidated C-terminus

<400>  67

His Ile Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gly 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Asn Arg Val Lys Asn Lys 
        35              


<210>  68
<211>  38
<212>  PRT
<213>  Rana Ridibunda

<400>  68

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Ile Lys Asn Lys 
        35              


<210>  69
<211>  38
<212>  PRT
<213>  Oncorhynchus nerka

<400>  69

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Arg 
            20                  25                  30          


Gln Arg Tyr Arg Asn Lys 
        35              


<210>  70
<211>  61
<212>  PRT
<213>  Lutzomyia longipalpis


<220>
<221>  DISULFID
<222>  (1)..(5)

<220>
<221>  DISULFID
<222>  (14)..(51)

<400>  70

Cys Asp Ala Thr Cys Gln Phe Arg Lys Ala Ile Glu Asp Cys Arg Lys 
1               5                   10                  15      


Lys Ala His His Ser Asp Val Leu Gln Thr Ser Val Gln Thr Thr Ala 
            20                  25                  30          


Thr Phe Thr Ser Met Asp Thr Ser Gln Leu Pro Gly Ser Gly Val Phe 
        35                  40                  45              


Lys Glu Cys Met Lys Gln Lys Ala Lys Glu Phe Lys Ala 
    50                  55                  60      


