                         SEQUENCE LISTING

<110>  Max-Planck-Gesellschaft zur Frderung der Wissenschaften 
       e.V. -Max-Planck-Institut fr Biochemie
 
<120>  FGFR4 Arg385 Cancer Model

<130>  43589P WO

<141>  2009-09-29

<160>  77    

<170>  PatentIn version 3.3

<210>  1
<211>  799
<212>  PRT
<213>  Mus sp.


<220>
<221>  MISC_FEATURE
<223>  FGFR4

<400>  1

Met Trp Leu Leu Leu Ala Leu Leu Ser Ile Phe Gln Gly Thr Pro Ala 
1               5                   10                  15      


Leu Ser Leu Glu Ala Ser Glu Glu Met Glu Gln Glu Pro Cys Leu Ala 
            20                  25                  30          


Pro Ile Leu Glu Gln Gln Glu Gln Val Leu Thr Val Ala Leu Gly Gln 
        35                  40                  45              


Pro Val Arg Leu Cys Cys Gly Arg Thr Glu Arg Gly Arg His Trp Tyr 
    50                  55                  60                  


Lys Glu Gly Ser Arg Leu Ala Ser Ala Gly Arg Val Arg Gly Trp Arg 
65                  70                  75                  80  


Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala Gly Arg Tyr 
                85                  90                  95      


Leu Cys Leu Ala Arg Gly Ser Met Thr Val Val His Asn Leu Thr Leu 
            100                 105                 110         


Leu Met Asp Asp Ser Leu Thr Ser Ile Ser Asn Asp Glu Asp Pro Lys 
        115                 120                 125             


Thr Leu Ser Ser Ser Ser Ser Gly His Val Tyr Pro Gln Gln Ala Pro 
    130                 135                 140                 


Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His Ala Val Pro 
145                 150                 155                 160 


Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly Asn Pro Met 
                165                 170                 175     


Pro Thr Ile His Trp Leu Lys Asp Gly Gln Ala Phe His Gly Glu Asn 
            180                 185                 190         


Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser Leu Val Met 
        195                 200                 205             


Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys Leu Val Glu 
    210                 215                 220                 


Asn Ser Leu Gly Ser Ile Arg Tyr Ser Tyr Leu Leu Asp Val Leu Glu 
225                 230                 235                 240 


Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Thr 
                245                 250                 255     


Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys Val Tyr Ser 
            260                 265                 270         


Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Val Ile Asn Gly 
        275                 280                 285             


Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val Leu Lys Thr 
    290                 295                 300                 


Thr Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu Arg Asn Val 
305                 310                 315                 320 


Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile 
                325                 330                 335     


Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro Glu Glu Asp 
            340                 345                 350         


Leu Thr Trp Thr Thr Ala Thr Pro Glu Ala Arg Tyr Thr Asp Ile Ile 
        355                 360                 365             


Leu Tyr Val Ser Gly Ser Leu Val Leu Leu Val Leu Leu Leu Leu Ala 
    370                 375                 380                 


Gly Val Tyr His Arg Gln Val Ile Arg Gly His Tyr Ser Arg Gln Pro 
385                 390                 395                 400 


Val Thr Ile Gln Lys Leu Ser Arg Phe Pro Leu Ala Arg Gln Phe Ser 
                405                 410                 415     


Leu Glu Ser Arg Ser Ser Gly Lys Ser Ser Leu Ser Leu Val Arg Gly 
            420                 425                 430         


Val Arg Leu Ser Ser Ser Gly Pro Pro Leu Leu Thr Gly Leu Val Asn 
        435                 440                 445             


Leu Asp Leu Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg Asp Arg Leu 
    450                 455                 460                 


Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Arg 
465                 470                 475                 480 


Ala Glu Ala Phe Gly Met Asp Pro Ser Arg Pro Asp Gln Thr Ser Thr 
                485                 490                 495     


Val Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys Asp Leu Ala 
            500                 505                 510         


Asp Leu Val Ser Glu Met Glu Val Met Lys Leu Ile Gly Arg His Lys 
        515                 520                 525             


Asn Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly Pro Leu Tyr 
    530                 535                 540                 


Val Ile Val Glu Cys Ala Ala Lys Gly Asn Leu Arg Glu Phe Leu Arg 
545                 550                 555                 560 


Ala Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly Pro Arg Ser 
                565                 570                 575     


Ser Glu Gly Pro Leu Ser Phe Pro Ala Leu Val Ser Cys Ala Tyr Gln 
            580                 585                 590         


Val Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys Ile His Arg 
        595                 600                 605             


Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asp Val Met Lys 
    610                 615                 620                 


Ile Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile Asp Tyr Tyr 
625                 630                 635                 640 


Lys Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu 
                645                 650                 655     


Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe 
            660                 665                 670         


Gly Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro 
        675                 680                 685             


Gly Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu Gly His Arg 
    690                 695                 700                 


Met Glu Arg Pro Pro Asn Cys Pro Ser Glu Leu Tyr Gly Leu Met Arg 
705                 710                 715                 720 


Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu 
                725                 730                 735     


Val Glu Ala Leu Asp Lys Val Leu Leu Ala Val Ser Glu Glu Tyr Leu 
            740                 745                 750         


Asp Leu Arg Leu Thr Phe Gly Pro Phe Ser Pro Ser Asn Gly Asp Ala 
        755                 760                 765             


Ser Ser Thr Cys Ser Ser Ser Asp Ser Val Phe Ser His Asp Pro Leu 
    770                 775                 780                 


Pro Leu Glu Pro Ser Pro Phe Pro Phe Ser Asp Ser Gln Thr Thr 
785                 790                 795                 


<210>  2
<211>  802
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  isoform 1

<220>
<221>  MISC_FEATURE
<223>  FGFR4 human isoform 1

<400>  2

Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly 
1               5                   10                  15      


Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro 
            20                  25                  30          


Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala 
        35                  40                  45              


Leu Gly Gln Pro Val Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly 
    50                  55                  60                  


His Trp Tyr Lys Glu Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg 
65                  70                  75                  80  


Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala 
                85                  90                  95      


Gly Arg Tyr Leu Cys Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn 
            100                 105                 110         


Leu Thr Leu Ile Thr Gly Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu 
        115                 120                 125             


Asp Pro Lys Ser His Arg Asp Pro Ser Asn Arg His Ser Tyr Pro Gln 
    130                 135                 140                 


Gln Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His 
145                 150                 155                 160 


Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly 
                165                 170                 175     


Asn Pro Thr Pro Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His 
            180                 185                 190         


Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser 
        195                 200                 205             


Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys 
    210                 215                 220                 


Leu Val Glu Asn Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp 
225                 230                 235                 240 


Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro 
                245                 250                 255     


Ala Asn Thr Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys 
            260                 265                 270         


Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val 
        275                 280                 285             


Ile Asn Gly Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val 
    290                 295                 300                 


Leu Lys Thr Ala Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu 
305                 310                 315                 320 


Arg Asn Val Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
                325                 330                 335     


Asn Ser Ile Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro 
            340                 345                 350         


Glu Glu Asp Pro Thr Trp Thr Ala Ala Ala Pro Glu Ala Arg Tyr Thr 
        355                 360                 365             


Asp Ile Ile Leu Tyr Ala Ser Gly Ser Leu Ala Leu Ala Val Leu Leu 
    370                 375                 380                 


Leu Leu Ala Gly Leu Tyr Arg Gly Gln Ala Leu His Gly Arg His Pro 
385                 390                 395                 400 


Arg Pro Pro Ala Thr Val Gln Lys Leu Ser Arg Phe Pro Leu Ala Arg 
                405                 410                 415     


Gln Phe Ser Leu Glu Ser Gly Ser Ser Gly Lys Ser Ser Ser Ser Leu 
            420                 425                 430         


Val Arg Gly Val Arg Leu Ser Ser Ser Gly Pro Ala Leu Leu Ala Gly 
        435                 440                 445             


Leu Val Ser Leu Asp Leu Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg 
    450                 455                 460                 


Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln 
465                 470                 475                 480 


Val Val Arg Ala Glu Ala Phe Gly Met Asp Pro Ala Arg Pro Asp Gln 
                485                 490                 495     


Ala Ser Thr Val Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys 
            500                 505                 510         


Asp Leu Ala Asp Leu Val Ser Glu Met Glu Val Met Lys Leu Ile Gly 
        515                 520                 525             


Arg His Lys Asn Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly 
    530                 535                 540                 


Pro Leu Tyr Val Ile Val Glu Cys Ala Ala Lys Gly Asn Leu Arg Glu 
545                 550                 555                 560 


Phe Leu Arg Ala Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly 
                565                 570                 575     


Pro Arg Ser Ser Glu Gly Pro Leu Ser Phe Pro Val Leu Val Ser Cys 
            580                 585                 590         


Ala Tyr Gln Val Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys 
        595                 600                 605             


Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn 
    610                 615                 620                 


Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile 
625                 630                 635                 640 


Asp Tyr Tyr Lys Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met 
                645                 650                 655     


Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val 
            660                 665                 670         


Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser 
        675                 680                 685             


Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu 
    690                 695                 700                 


Gly His Arg Met Asp Arg Pro Pro His Cys Pro Pro Glu Leu Tyr Gly 
705                 710                 715                 720 


Leu Met Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe 
                725                 730                 735     


Lys Gln Leu Val Glu Ala Leu Asp Lys Val Leu Leu Ala Val Ser Glu 
            740                 745                 750         


Glu Tyr Leu Asp Leu Arg Leu Thr Phe Gly Pro Tyr Ser Pro Ser Gly 
        755                 760                 765             


Gly Asp Ala Ser Ser Thr Cys Ser Ser Ser Asp Ser Val Phe Ser His 
    770                 775                 780                 


Asp Pro Leu Pro Leu Gly Ser Ser Ser Phe Pro Phe Gly Ser Gly Val 
785                 790                 795                 800 


Gln Thr 
        


<210>  3
<211>  802
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  FGFR4 human isoform 2

<400>  3

Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly 
1               5                   10                  15      


Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro 
            20                  25                  30          


Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala 
        35                  40                  45              


Leu Gly Gln Pro Val Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly 
    50                  55                  60                  


His Trp Tyr Lys Glu Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg 
65                  70                  75                  80  


Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala 
                85                  90                  95      


Gly Arg Tyr Leu Cys Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn 
            100                 105                 110         


Leu Thr Leu Ile Thr Gly Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu 
        115                 120                 125             


Asp Pro Lys Ser His Arg Asp Pro Ser Asn Arg His Ser Tyr Pro Gln 
    130                 135                 140                 


Gln Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His 
145                 150                 155                 160 


Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly 
                165                 170                 175     


Asn Pro Thr Pro Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His 
            180                 185                 190         


Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser 
        195                 200                 205             


Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys 
    210                 215                 220                 


Leu Val Glu Asn Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp 
225                 230                 235                 240 


Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro 
                245                 250                 255     


Ala Asn Thr Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys 
            260                 265                 270         


Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val 
        275                 280                 285             


Ile Asn Gly Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val 
    290                 295                 300                 


Leu Lys Thr Ala Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu 
305                 310                 315                 320 


Arg Asn Val Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
                325                 330                 335     


Asn Ser Ile Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro 
            340                 345                 350         


Glu Glu Asp Pro Thr Trp Thr Ala Ala Ala Pro Glu Ala Arg Tyr Thr 
        355                 360                 365             


Asp Ile Ile Leu Tyr Ala Ser Gly Ser Leu Ala Leu Ala Val Leu Leu 
    370                 375                 380                 


Leu Leu Ala Gly Leu Tyr Arg Gly Gln Ala Leu His Gly Arg His Pro 
385                 390                 395                 400 


Arg Pro Pro Ala Thr Val Gln Lys Leu Ser Arg Phe Pro Leu Ala Arg 
                405                 410                 415     


Gln Phe Ser Leu Glu Ser Gly Ser Ser Gly Lys Ser Ser Ser Ser Leu 
            420                 425                 430         


Val Arg Gly Val Arg Leu Ser Ser Ser Gly Pro Ala Leu Leu Ala Gly 
        435                 440                 445             


Leu Val Ser Leu Asp Leu Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg 
    450                 455                 460                 


Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln 
465                 470                 475                 480 


Val Val Arg Ala Glu Ala Phe Gly Met Asp Pro Ala Arg Pro Asp Gln 
                485                 490                 495     


Ala Ser Thr Val Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys 
            500                 505                 510         


Asp Leu Ala Asp Leu Val Ser Glu Met Glu Val Met Lys Leu Ile Gly 
        515                 520                 525             


Arg His Lys Asn Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly 
    530                 535                 540                 


Pro Leu Tyr Val Ile Val Glu Cys Ala Ala Lys Gly Asn Leu Arg Glu 
545                 550                 555                 560 


Phe Leu Arg Ala Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly 
                565                 570                 575     


Pro Arg Ser Ser Glu Gly Pro Leu Ser Phe Pro Val Leu Val Ser Cys 
            580                 585                 590         


Ala Tyr Gln Val Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys 
        595                 600                 605             


Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn 
    610                 615                 620                 


Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile 
625                 630                 635                 640 


Asp Tyr Tyr Lys Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met 
                645                 650                 655     


Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val 
            660                 665                 670         


Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser 
        675                 680                 685             


Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu 
    690                 695                 700                 


Gly His Arg Met Asp Arg Pro Pro His Cys Pro Pro Glu Leu Tyr Gly 
705                 710                 715                 720 


Leu Met Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe 
                725                 730                 735     


Lys Gln Leu Val Glu Ala Leu Asp Lys Val Leu Leu Ala Val Ser Glu 
            740                 745                 750         


Glu Tyr Leu Asp Leu Arg Leu Thr Phe Gly Pro Tyr Ser Pro Ser Gly 
        755                 760                 765             


Gly Asp Ala Ser Ser Thr Cys Ser Ser Ser Asp Ser Val Phe Ser His 
    770                 775                 780                 


Asp Pro Leu Pro Leu Gly Ser Ser Ser Phe Pro Phe Gly Ser Gly Val 
785                 790                 795                 800 


Gln Thr 
        


<210>  4
<211>  800
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  MISC_FEATURE
<223>  FGFR4

<400>  4

Met Trp Leu Leu Leu Ala Leu Leu Ser Ile Phe Gln Glu Thr Pro Ala 
1               5                   10                  15      


Phe Ser Leu Glu Ala Ser Glu Glu Met Glu Gln Glu Pro Cys Pro Ala 
            20                  25                  30          


Pro Ile Ser Glu Gln Gln Glu Gln Val Leu Thr Val Ala Leu Gly Gln 
        35                  40                  45              


Pro Val Arg Leu Cys Cys Gly Arg Thr Glu Arg Gly Arg His Trp Tyr 
    50                  55                  60                  


Lys Glu Gly Ser Arg Leu Ala Ser Ala Gly Arg Val Arg Gly Trp Arg 
65                  70                  75                  80  


Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala Gly Arg Tyr 
                85                  90                  95      


Leu Cys Leu Ala Arg Gly Ser Met Thr Val Val His Asn Leu Thr Leu 
            100                 105                 110         


Ile Met Asp Asp Ser Leu Pro Ser Ile Asn Asn Glu Asp Pro Lys Thr 
        115                 120                 125             


Leu Ser Ser Ser Ser Ser Gly His Ser Tyr Leu Gln Gln Ala Pro Tyr 
    130                 135                 140                 


Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His Ala Val Pro Ala 
145                 150                 155                 160 


Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly Asn Pro Met Pro 
                165                 170                 175     


Thr Ile His Trp Leu Lys Asn Gly Gln Ala Phe His Gly Glu Asn Arg 
            180                 185                 190         


Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser Leu Val Met Glu 
        195                 200                 205             


Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys Leu Val Glu Asn 
    210                 215                 220                 


Ser Leu Gly Ser Ile Arg Tyr Ser Tyr Leu Leu Asp Val Leu Glu Arg 
225                 230                 235                 240 


Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Thr Thr 
                245                 250                 255     


Ala Val Val Gly Ser Asn Val Glu Leu Leu Cys Lys Val Tyr Ser Asp 
            260                 265                 270         


Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val Ile Asn Gly Ser 
        275                 280                 285             


Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val Leu Lys Thr Thr 
    290                 295                 300                 


Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu Arg Asn Val Ser 
305                 310                 315                 320 


Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly 
                325                 330                 335     


Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro Ala Glu Glu Glu 
            340                 345                 350         


Asp Leu Ala Trp Thr Thr Ala Thr Ser Glu Ala Arg Tyr Thr Asp Ile 
        355                 360                 365             


Ile Leu Tyr Val Ser Gly Ser Leu Ala Leu Val Leu Leu Leu Leu Leu 
    370                 375                 380                 


Ala Gly Val Tyr His Arg Gln Ala Ile His Gly His His Ser Arg Gln 
385                 390                 395                 400 


Pro Val Thr Val Gln Lys Leu Ser Arg Phe Pro Leu Ala Arg Gln Phe 
                405                 410                 415     


Ser Leu Glu Ser Arg Ser Ser Gly Lys Ser Ser Leu Ser Leu Val Arg 
            420                 425                 430         


Gly Val Arg Leu Ser Ser Ser Gly Pro Pro Leu Leu Thr Gly Leu Val 
        435                 440                 445             


Ser Leu Asp Leu Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg Asp Arg 
    450                 455                 460                 


Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val 
465                 470                 475                 480 


Arg Ala Glu Ala Leu Gly Met Asp Ser Ser Arg Pro Asp Gln Thr Ser 
                485                 490                 495     


Thr Val Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys Asp Leu 
            500                 505                 510         


Ala Asp Leu Ile Ser Glu Met Glu Met Met Lys Leu Ile Gly Arg His 
        515                 520                 525             


Lys Asn Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly Pro Leu 
    530                 535                 540                 


Tyr Val Ile Val Glu Tyr Ala Ala Lys Gly Asn Leu Arg Glu Phe Leu 
545                 550                 555                 560 


Arg Ala Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly Pro Arg 
                565                 570                 575     


Ser Ser Glu Gly Pro Leu Ser Phe Pro Ala Leu Val Ser Cys Ala Tyr 
            580                 585                 590         


Gln Val Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys Ile His 
        595                 600                 605             


Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asp Val Met 
    610                 615                 620                 


Lys Ile Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile Asp Tyr 
625                 630                 635                 640 


Tyr Lys Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro 
                645                 650                 655     


Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser 
            660                 665                 670         


Phe Gly Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr 
        675                 680                 685             


Pro Gly Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu Gly His 
    690                 695                 700                 


Arg Met Glu Arg Pro Pro Asn Cys Pro Ser Glu Leu Tyr Gly Leu Met 
705                 710                 715                 720 


Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe Lys Gln 
                725                 730                 735     


Leu Val Glu Ala Leu Asp Lys Val Leu Leu Ala Val Ser Glu Glu Tyr 
            740                 745                 750         


Leu Asp Leu Arg Leu Thr Phe Gly Pro Tyr Ser Pro Asn Asn Gly Asp 
        755                 760                 765             


Ala Ser Ser Thr Cys Ser Ser Ser Asp Ser Val Phe Ser His Asp Pro 
    770                 775                 780                 


Leu Pro Leu Glu Pro Ser Pro Phe Pro Phe Pro Glu Ala Gln Thr Thr 
785                 790                 795                 800 


<210>  5
<211>  799
<212>  PRT
<213>  Mus sp.


<220>
<221>  MISC_FEATURE
<223>  FGFR4: G to R substitution

<400>  5

Met Trp Leu Leu Leu Ala Leu Leu Ser Ile Phe Gln Gly Thr Pro Ala 
1               5                   10                  15      


Leu Ser Leu Glu Ala Ser Glu Glu Met Glu Gln Glu Pro Cys Leu Ala 
            20                  25                  30          


Pro Ile Leu Glu Gln Gln Glu Gln Val Leu Thr Val Ala Leu Gly Gln 
        35                  40                  45              


Pro Val Arg Leu Cys Cys Gly Arg Thr Glu Arg Gly Arg His Trp Tyr 
    50                  55                  60                  


Lys Glu Gly Ser Arg Leu Ala Ser Ala Gly Arg Val Arg Gly Trp Arg 
65                  70                  75                  80  


Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala Gly Arg Tyr 
                85                  90                  95      


Leu Cys Leu Ala Arg Gly Ser Met Thr Val Val His Asn Leu Thr Leu 
            100                 105                 110         


Leu Met Asp Asp Ser Leu Thr Ser Ile Ser Asn Asp Glu Asp Pro Lys 
        115                 120                 125             


Thr Leu Ser Ser Ser Ser Ser Gly His Val Tyr Pro Gln Gln Ala Pro 
    130                 135                 140                 


Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His Ala Val Pro 
145                 150                 155                 160 


Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly Asn Pro Met 
                165                 170                 175     


Pro Thr Ile His Trp Leu Lys Asp Gly Gln Ala Phe His Gly Glu Asn 
            180                 185                 190         


Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser Leu Val Met 
        195                 200                 205             


Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys Leu Val Glu 
    210                 215                 220                 


Asn Ser Leu Gly Ser Ile Arg Tyr Ser Tyr Leu Leu Asp Val Leu Glu 
225                 230                 235                 240 


Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Thr 
                245                 250                 255     


Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys Val Tyr Ser 
            260                 265                 270         


Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Val Ile Asn Gly 
        275                 280                 285             


Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val Leu Lys Thr 
    290                 295                 300                 


Thr Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu Arg Asn Val 
305                 310                 315                 320 


Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile 
                325                 330                 335     


Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro Glu Glu Asp 
            340                 345                 350         


Leu Thr Trp Thr Thr Ala Thr Pro Glu Ala Arg Tyr Thr Asp Ile Ile 
        355                 360                 365             


Leu Tyr Val Ser Gly Ser Leu Val Leu Leu Val Leu Leu Leu Leu Ala 
    370                 375                 380                 


Arg Val Tyr His Arg Gln Val Ile Arg Gly His Tyr Ser Arg Gln Pro 
385                 390                 395                 400 


Val Thr Ile Gln Lys Leu Ser Arg Phe Pro Leu Ala Arg Gln Phe Ser 
                405                 410                 415     


Leu Glu Ser Arg Ser Ser Gly Lys Ser Ser Leu Ser Leu Val Arg Gly 
            420                 425                 430         


Val Arg Leu Ser Ser Ser Gly Pro Pro Leu Leu Thr Gly Leu Val Asn 
        435                 440                 445             


Leu Asp Leu Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg Asp Arg Leu 
    450                 455                 460                 


Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Arg 
465                 470                 475                 480 


Ala Glu Ala Phe Gly Met Asp Pro Ser Arg Pro Asp Gln Thr Ser Thr 
                485                 490                 495     


Val Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys Asp Leu Ala 
            500                 505                 510         


Asp Leu Val Ser Glu Met Glu Val Met Lys Leu Ile Gly Arg His Lys 
        515                 520                 525             


Asn Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly Pro Leu Tyr 
    530                 535                 540                 


Val Ile Val Glu Cys Ala Ala Lys Gly Asn Leu Arg Glu Phe Leu Arg 
545                 550                 555                 560 


Ala Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly Pro Arg Ser 
                565                 570                 575     


Ser Glu Gly Pro Leu Ser Phe Pro Ala Leu Val Ser Cys Ala Tyr Gln 
            580                 585                 590         


Val Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys Ile His Arg 
        595                 600                 605             


Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asp Val Met Lys 
    610                 615                 620                 


Ile Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile Asp Tyr Tyr 
625                 630                 635                 640 


Lys Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu 
                645                 650                 655     


Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe 
            660                 665                 670         


Gly Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro 
        675                 680                 685             


Gly Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu Gly His Arg 
    690                 695                 700                 


Met Glu Arg Pro Pro Asn Cys Pro Ser Glu Leu Tyr Gly Leu Met Arg 
705                 710                 715                 720 


Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu 
                725                 730                 735     


Val Glu Ala Leu Asp Lys Val Leu Leu Ala Val Ser Glu Glu Tyr Leu 
            740                 745                 750         


Asp Leu Arg Leu Thr Phe Gly Pro Phe Ser Pro Ser Asn Gly Asp Ala 
        755                 760                 765             


Ser Ser Thr Cys Ser Ser Ser Asp Ser Val Phe Ser His Asp Pro Leu 
    770                 775                 780                 


Pro Leu Glu Pro Ser Pro Phe Pro Phe Ser Asp Ser Gln Thr Thr 
785                 790                 795                 


<210>  6
<211>  800
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  MISC_FEATURE
<223>  FGFR4: G to R substitution

<400>  6

Met Trp Leu Leu Leu Ala Leu Leu Ser Ile Phe Gln Glu Thr Pro Ala 
1               5                   10                  15      


Phe Ser Leu Glu Ala Ser Glu Glu Met Glu Gln Glu Pro Cys Pro Ala 
            20                  25                  30          


Pro Ile Ser Glu Gln Gln Glu Gln Val Leu Thr Val Ala Leu Gly Gln 
        35                  40                  45              


Pro Val Arg Leu Cys Cys Gly Arg Thr Glu Arg Gly Arg His Trp Tyr 
    50                  55                  60                  


Lys Glu Gly Ser Arg Leu Ala Ser Ala Gly Arg Val Arg Gly Trp Arg 
65                  70                  75                  80  


Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala Gly Arg Tyr 
                85                  90                  95      


Leu Cys Leu Ala Arg Gly Ser Met Thr Val Val His Asn Leu Thr Leu 
            100                 105                 110         


Ile Met Asp Asp Ser Leu Pro Ser Ile Asn Asn Glu Asp Pro Lys Thr 
        115                 120                 125             


Leu Ser Ser Ser Ser Ser Gly His Ser Tyr Leu Gln Gln Ala Pro Tyr 
    130                 135                 140                 


Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His Ala Val Pro Ala 
145                 150                 155                 160 


Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly Asn Pro Met Pro 
                165                 170                 175     


Thr Ile His Trp Leu Lys Asn Gly Gln Ala Phe His Gly Glu Asn Arg 
            180                 185                 190         


Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser Leu Val Met Glu 
        195                 200                 205             


Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys Leu Val Glu Asn 
    210                 215                 220                 


Ser Leu Gly Ser Ile Arg Tyr Ser Tyr Leu Leu Asp Val Leu Glu Arg 
225                 230                 235                 240 


Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Thr Thr 
                245                 250                 255     


Ala Val Val Gly Ser Asn Val Glu Leu Leu Cys Lys Val Tyr Ser Asp 
            260                 265                 270         


Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val Ile Asn Gly Ser 
        275                 280                 285             


Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val Leu Lys Thr Thr 
    290                 295                 300                 


Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu Arg Asn Val Ser 
305                 310                 315                 320 


Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly 
                325                 330                 335     


Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro Ala Glu Glu Glu 
            340                 345                 350         


Asp Leu Ala Trp Thr Thr Ala Thr Ser Glu Ala Arg Tyr Thr Asp Ile 
        355                 360                 365             


Ile Leu Tyr Val Ser Gly Ser Leu Ala Leu Val Leu Leu Leu Leu Leu 
    370                 375                 380                 


Ala Arg Val Tyr His Arg Gln Ala Ile His Gly His His Ser Arg Gln 
385                 390                 395                 400 


Pro Val Thr Val Gln Lys Leu Ser Arg Phe Pro Leu Ala Arg Gln Phe 
                405                 410                 415     


Ser Leu Glu Ser Arg Ser Ser Gly Lys Ser Ser Leu Ser Leu Val Arg 
            420                 425                 430         


Gly Val Arg Leu Ser Ser Ser Gly Pro Pro Leu Leu Thr Gly Leu Val 
        435                 440                 445             


Ser Leu Asp Leu Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg Asp Arg 
    450                 455                 460                 


Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val 
465                 470                 475                 480 


Arg Ala Glu Ala Leu Gly Met Asp Ser Ser Arg Pro Asp Gln Thr Ser 
                485                 490                 495     


Thr Val Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys Asp Leu 
            500                 505                 510         


Ala Asp Leu Ile Ser Glu Met Glu Met Met Lys Leu Ile Gly Arg His 
        515                 520                 525             


Lys Asn Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly Pro Leu 
    530                 535                 540                 


Tyr Val Ile Val Glu Tyr Ala Ala Lys Gly Asn Leu Arg Glu Phe Leu 
545                 550                 555                 560 


Arg Ala Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly Pro Arg 
                565                 570                 575     


Ser Ser Glu Gly Pro Leu Ser Phe Pro Ala Leu Val Ser Cys Ala Tyr 
            580                 585                 590         


Gln Val Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys Ile His 
        595                 600                 605             


Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asp Val Met 
    610                 615                 620                 


Lys Ile Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile Asp Tyr 
625                 630                 635                 640 


Tyr Lys Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro 
                645                 650                 655     


Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser 
            660                 665                 670         


Phe Gly Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr 
        675                 680                 685             


Pro Gly Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu Gly His 
    690                 695                 700                 


Arg Met Glu Arg Pro Pro Asn Cys Pro Ser Glu Leu Tyr Gly Leu Met 
705                 710                 715                 720 


Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe Lys Gln 
                725                 730                 735     


Leu Val Glu Ala Leu Asp Lys Val Leu Leu Ala Val Ser Glu Glu Tyr 
            740                 745                 750         


Leu Asp Leu Arg Leu Thr Phe Gly Pro Tyr Ser Pro Asn Asn Gly Asp 
        755                 760                 765             


Ala Ser Ser Thr Cys Ser Ser Ser Asp Ser Val Phe Ser His Asp Pro 
    770                 775                 780                 


Leu Pro Leu Glu Pro Ser Pro Phe Pro Phe Pro Glu Ala Gln Thr Thr 
785                 790                 795                 800 


<210>  7
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  neoR-specific primer

<400>  7
aggatctcct gtcatctcac cttcctcctg                                      30


<210>  8
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  neoR-specific primer

<400>  8
aagaactcgt caagaaggcg atagaaggcg                                      30


<210>  9
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Cre-specific primer

<400>  9
aacatgcttc atcgtcgg                                                   18


<210>  10
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Cre-specific primer

<400>  10
ttaggatcat cagctacacc                                                 20


<210>  11
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  FGFR4-primer forward

<400>  11
cgtggacaac agcaacccct g                                               21


<210>  12
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  FGFR4-primer reverse

<400>  12
gctggcgaga gtagtggcca cg                                              22


<210>  13
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  TGF-alpha primer forward

<400>  13
tgtcaggctc tggagaacag c                                               21


<210>  14
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  TGF-alpha primer reverse

<400>  14
cacagcgaac acccacgtac c                                               21


<210>  15
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  PymT primer forward

<400>  15
tcgccgccta agactgc                                                    17


<210>  16
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  PymT primer reverse

<400>  16
ccgccctggg aatgatag                                                   18


<210>  17
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  HPRT primer fw

<400>  17
ataagccaga ctttgttgga                                                 20


<210>  18
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  HPRT primer rev

<400>  18
ccacttgaac tctcatctta gg                                              22


<210>  19
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  GAPDH primer fw

<400>  19
ccaatatgat tccacccatg g                                               21


<210>  20
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  GAPDH primer rev

<400>  20
ccttctccat ggtggtgaag a                                               21


<210>  21
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  FGFR4 primer for Light Cycler(R) fw

<400>  21
gcttatggat gactccttac cct                                             23


<210>  22
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  FGFR4 primer for Light Cyler (R) rev

<400>  22
aatgcctcca atacgattct c                                               21


<210>  23
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  E-Cadherin primer fw

<400>  23
gctggaccga gagagtta                                                   18


<210>  24
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  E-Cadherin primer rev

<400>  24
tcgttctcca ctctcacat                                                  19


<210>  25
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  N-Cadherin primer fw

<400>  25
ccacagacat ggaaggcaat cc                                              22


<210>  26
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  N-Cadherin primer rev

<400>  26
cactgattct gtatgccgca ttc                                             23


<210>  27
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  MMP14 primer fw

<400>  27
cgttcgctgc tggacaagg                                                  19


<210>  28
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  MMP14 primer rev

<400>  28
gactgagaag ggaggctgga g                                               21


<210>  29
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  MMP13 primer fw

<400>  29
tccctggaat tggcaacaaa g                                               21


<210>  30
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  MMP13 primer rev

<400>  30
ggaatttgtt ggcatgactc tcac                                            24


<210>  31
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  MMP9 primer fw

<400>  31
ccctggaact cacacgaca                                                  19


<210>  32
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  MMP9 primer rev

<400>  32
ggaaactcac acgccagaag                                                 20


<210>  33
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  CD44 primer fw

<400>  33
ttgaatgtaa cctgccgcta cgca                                            24


<210>  34
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  CD44 primer rev

<400>  34
tcggatccat gagtcacagt gcg                                             23


<210>  35
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  flk-1 primer fw

<400>  35
tcgtgcgtga catcaaagag                                                 20


<210>  36
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  flk-1 primer rev

<400>  36
tggacagtga ggccaggatg                                                 20


<210>  37
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  CDK4 primer fw

<400>  37
tggctgccac tcgatatgaa c                                               21


<210>  38
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  CDK4 primer rev

<400>  38
cctcaggtcc tggtctatat g                                               21


<210>  39
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Rb primer fw

<400>  39
catctaatgg acttccagag                                                 20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Rb primer rev !!!

<400>  40
cataacagtc ctaactggag                                                 20


<210>  41
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  p21 primer fw

<400>  41
cgttttcggc cctgagatgt t                                               21


<210>  42
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  p21 primer rev

<400>  42
acccgggtcc ttcttgtgtt tc                                              22


<210>  43
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  p53 primer fw

<400>  43
aaccgccgac ctatccttac catc                                            24


<210>  44
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  p53 primer rev

<400>  44
aggccccact ttcttgacca ttgt                                            24


<210>  45
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  cyclin D1 primer fw

<400>  45
tcccgctggc catgaactac c                                               21


<210>  46
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  cyclin D1 primer rev

<400>  46
ggcgcaggct tgactccaga a                                               21


<210>  47
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  CDK1 primer fw

<400>  47
ccatgaactg cccaggag                                                   18


<210>  48
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  CDK1 primer rev

<400>  48
cggtgtggtg tataagggta ga                                              22


<210>  49
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CDK2 primer fw

<400>  49
cgataacaag ctccgtccat                                                 20


<210>  50
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CDK2 primer rev

<400>  50
agaagtggct gcatcacaag                                                 20


<210>  51
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  blocking peptide

<400>  51

Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly 
1               5                   10                  15      


Pro Pro Val Leu Ser 
            20      


<210>  52
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  blocking peptide

<400>  52

Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro Cys Leu Ala Pro Ser 
1               5                   10                  15      


Leu Glu Gln Gln Glu 
            20      


<210>  53
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  blocking peptide

<400>  53

Gln Glu Leu Thr Val Ala Leu Gly Gln Pro Val Arg 
1               5                   10          


<210>  54
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  blocking peptide

<400>  54

Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly His Trp Tyr Lys 
1               5                   10                  


<210>  55
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  blocking peptide

<400>  55

Glu Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg Gly Trp Arg Gly 
1               5                   10                  15      


Arg 
    


<210>  56
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  blocking peptide

<400>  56

Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala Gly Arg Tyr Leu Cys 
1               5                   10                  15      


Leu Ala Arg 
            


<210>  57
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  blocking peptide

<400>  57

Gly Ser Met Ile Val Leu Gln Asn Leu Thr Leu Ile Thr Gly Asp Ser 
1               5                   10                  15      


Leu Thr Ser 
            


<210>  58
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  blocking peptide

<400>  58

Ser Asn Asp Asp Glu Asp Pro Lys Ser His Arg Asp Pro Ser Asn Arg 
1               5                   10                  15      


<210>  59
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  blocking peptide

<400>  59

His Ser Tyr Pro Gln Gln Ala Pro Tyr Trp Thr His Pro Gln Arg 
1               5                   10                  15  


<210>  60
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  blocking peptide

<400>  60

Met Glu Lys Lys Leu His Ala Val Pro Ala Gly Asn Thr Val Lys 
1               5                   10                  15  


<210>  61
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  blocking peptide

<400>  61

Phe Arg Cys Pro Ala Ala Gly Asn Pro Thr Pro Thr Ile Arg 
1               5                   10                  


<210>  62
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  blocking peptide

<400>  62

Trp Leu Lys Asp Gly Gln Ala Phe His Gly Glu Asn Arg 
1               5                   10              


<210>  63
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  blocking peptide

<400>  63

Ile Gly Gly Ile Arg Leu Arg 
1               5           


<210>  64
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  blocking peptide

<400>  64

His Gln His Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg 
1               5                   10                  15      


<210>  65
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  blocking peptide

<400>  65

Gly Thr Tyr Thr Cys Leu Val Glu Asn Ala Val Gly Ser Ile Arg 
1               5                   10                  15  


<210>  66
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  blocking peptide

<400>  66

Tyr Asn Tyr Leu Leu Asp Val Leu Glu Arg Ser Pro His Arg 
1               5                   10                  


<210>  67
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  blocking peptide

<400>  67

Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Thr Thr Ala Val Val Gly 
1               5                   10                  15      


Ser Asp Val Glu 
            20  


<210>  68
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  blocking peptide

<400>  68

Leu Leu Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu 
1               5                   10                  15      


Lys 
    


<210>  69
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  blocking peptide

<400>  69

His Ile Val Ile Asn Gly Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr 
1               5                   10                  15      


Val Gln Val Leu Lys 
            20      


<210>  70
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  blocking peptide

<400>  70

Thr Ala Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu Arg Asn 
1               5                   10                  15      


Val Ser Ala Glu 
            20  


<210>  71
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  blocking peptide

<400>  71

Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser 
1               5                   10                  15      


Tyr Gln Ser Ala 
            20  


<210>  72
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  blocking peptide

<400>  72

Trp Leu Thr Val Leu Pro Glu Glu Asp Pro Thr Trp Thr Ala Ala Ala 
1               5                   10                  15      


Pro Glu Ala Arg 
            20  


<210>  73
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  blocking peptide

<400>  73

Tyr Thr Asp Ile Ile Leu Tyr Ala Ser Gly Ser Leu Ala Leu Ala Val 
1               5                   10                  15      


Leu Leu Leu Leu Ala Gly Leu Tyr Arg 
            20                  25  


<210>  74
<211>  3772
<212>  DNA
<213>  Mus musculus


<220>
<221>  mRNA
<222>  (1)..(3772)
<223>  transforming growth factor alpha (TGF alpha)

<400>  74
gcgccttttt cccccgcgca caccgcggcg gcgcgcggct actcgccaac cgcagggagc     60

gcggtggctg cagcaccctg cgctcggaag atggtccccg cgaccggaca gctcgctctg    120

ctagcgctgg gtatcctgtt agctgtgtgc caggctctgg agaacagcac atcccccctg    180

agtgactcac ccgtggcggc tgcagtggtg tctcacttca acaagtgccc agattcccac    240

actcagtact gcttccatgg aacctgccgg tttttggtgc aggaagagaa gccagcatgt    300

gtctgccact ctgggtacgt gggtgttcgc tgtgagcatg cagacctcct ggctgtggtg    360

gctgccagcc agaagaagca agccatcact gccctggtgg tggtctccat tgtggccctg    420

gctgtcctca ttatcacctg tgtgctgatc cactgctgtc agctccgcaa acactgtgag    480

tggtgccgtg ccctcgtctg cagacatgag aagcccagcg ccctcctgaa gggaaggact    540

gcttgctgcc actctgagac agtggtctga agatcccaga ggaggaattt ggccaggtgg    600

cctatgacag cccaaccaag aaaaggcatc ttgggacaac acccctggca gtgcccaggc    660

ccatgggaca tgctgggaga ccttccccct cagtgcacaa ctgcctgggc aggcttcttc    720

cttgagagtc ttcaaaactg tgtgataaag ctgcctgctg ggctcgctca gtacacccag    780

agaagaggcc agtggaccac attttaaaga caagttgaac acgaacctca aagggttggc    840

cttcttgcta acccacaccg agaatgagct ggggctgctg tcccctgcca gccatgactt    900

ccagactgtt tcttctctat gggccatcta cccccccgtc ccgagactcc atggttggtg    960

tacaaaatgg acaaggggaa acgtctattg ttctttgaag acaccatggc gtcccatgcg   1020

ccctgacatc tcctcaggct gtcgtcagga tgcgtgtctt atttattaga tggataacat   1080

ggttttattt gtaatctctt tatgtcaatg tcaggcgtcc atgctagcga tgcatgagtg   1140

gcgggccgtg aagttacacc aaatagaaat gtccagccac tttgataaag taaggctgca   1200

gggaggggag cctccggggg gccgtagaga cagaattcag atgtgcatcc tgctgggaac   1260

caacctgcta tcccaaggct gtgccccctc aggcaagaaa gtccctggat acatgctgta   1320

gcaaacttag caaggccaat ggcagagagt gtcccccttg tggggacaag aggacaaaag   1380

agcctgtgtg ggcacctagg aaggatgcac accccaaccc ttgattaagt ggattagcgt   1440

cctcgtgagc ccagctccag catcagcaat gagctgtgag ccaaatccat gaaggggacc   1500

agccctttat tggcttttgc ttatttttag aaggagaaat ttgcctttcc tatttatttt   1560

caagcattaa gaaaaatagc ccactgtttt gttttgtttc ccctttaata atgttggcat   1620

tattaacaaa atcgctacca agcctctcca cccctctctg gggaaggaaa tgtgttccct   1680

gagcacccga agatgctctg acccattgag cccacccttg ttcctgggct gcttgggact   1740

gtcaggagac agaatacatt cagttgcata ttaaagagac cattctccaa ctcagaagtg   1800

aaaagtctgc cccctcggcc ctccagggcc tctgaagtaa ggcatgaggg aaggggtact   1860

gggcatacca agttggtttg aagcttctgt cagaagctgc ctgttcctca ttcttctcct   1920

ttatgaattt ttctcctctc atatgatcta ggcattgatc tgcccaggtc ttaacccttt   1980

gttcacaagg cctgaagccc tgaaagaaga acctgaaact gttcagtgct gtcctctaac   2040

tgcttagctg acacagctcc aggcagaagt tgtcattctt gctattattt tggtttgatg   2100

ctttatcttg ttttgtgaga caaggtcttg ctgtgtagcc caggttgacc tttaagttaa   2160

gatcctgctt cagcaacctg gaagctgggc ttacagatgt gcaccaccac gcccagcact   2220

ttttgattac tagagaaaat aggttaagtt tgctttcctt gggtcataca agtgggtcaa   2280

ggccaagtgt cacctgctgc tcagacacca atcaacctca ctggacttca gccctctatt   2340

ggcccccagt gctctcagta gaccccgcct gaagtactgg ctcactggag ggcagggagc   2400

aacacaaatg gaggagatgt ggggcttgtt ttagtttagt tcacactgtt agcttctgat   2460

gacaggtctt ttctggtctg ctggaggctc ctgggtgtct gacttctttt aaagagtttg   2520

aactgatatc aaaatatcat tgggaacttc ctcacttaat atcccatcct gaagatgttg   2580

tcatccaaga ctaagcagag gtggtaaacg cttagcacga gcactcgatg gtgaaggcag   2640

aggatctcgg gaggacctca gctttagtgt ccaaacggtc ctgttctcag gtccagccag   2700

tcgcagcagc cagtaccatc ccagtgcctg tacacagatg cagctggctc aaacacctcc   2760

cagaagtgcc ttcccatcag tctacccttt gcagagtcag aggctgagac taggttgaga   2820

caagtccggt tggacatcgt ccctgccccg acgtatgaca gccctgctgc gttggtgact   2880

ttgattttgg aagtcagtca gacaaacgct gtgtaccttc tcctgtgcca tgtcacagca   2940

cagatgggcc tggttagctg taccagcgcc ctcctgtcag ttcacactgg ccctctcttg   3000

atatttagta cagctactta atcaggagca ctcttagcag ctaggcaggt cagagggcag   3060

tacagttgat tcagtgactc aggggactag ggccattccc attaaatgag ctgaaattaa   3120

ttctagagac attgagacag ctcagttagc aatggcactt accaaaatcc cagataacct   3180

gaattcaatc ccctgggatc ccatctggtg gaaggagaga accggcttgc ccaggatgtc   3240

ttctgatttc tacgtacacg cacacgcaca cacacgcacg cgcacacaca cgcacacaca   3300

cgcacatatg agtacacaca aagtctaagt ttttaaaata aaaattctag aaagacctct   3360

acacctctag ctataacttt aaacacacca tgggacatgt tttctccacg gaaaagcaca   3420

attggagacc cagtctgaaa tgaaagatag attccaggtg gacatacaca gaaccaaacc   3480

atgagttagt ttgtcatgtg ccccagaaaa aggtgggaac aataatccca acatcccttt   3540

cctctccccc cccaaaaaag ggggggagga ggcatggttg gtacccaccc acctgcactg   3600

gtgagggaag tgactatgtc cctgagtcct agatggtgac gttggtccct tcaagtcccc   3660

aggccaggtt tcctagtgcc tatgaggcac tggatagacc agcaacactc tgacactgcc   3720

tacaggcccc agtcctgtaa tgagtaataa acttgtctct ctcccaaggc ca           3772


<210>  75
<211>  159
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(159)
<223>  TGF alpha

<400>  75

Met Val Pro Ala Thr Gly Gln Leu Ala Leu Leu Ala Leu Gly Ile Leu 
1               5                   10                  15      


Leu Ala Val Cys Gln Ala Leu Glu Asn Ser Thr Ser Pro Leu Ser Asp 
            20                  25                  30          


Ser Pro Val Ala Ala Ala Val Val Ser His Phe Asn Lys Cys Pro Asp 
        35                  40                  45              


Ser His Thr Gln Tyr Cys Phe His Gly Thr Cys Arg Phe Leu Val Gln 
    50                  55                  60                  


Glu Glu Lys Pro Ala Cys Val Cys His Ser Gly Tyr Val Gly Val Arg 
65                  70                  75                  80  


Cys Glu His Ala Asp Leu Leu Ala Val Val Ala Ala Ser Gln Lys Lys 
                85                  90                  95      


Gln Ala Ile Thr Ala Leu Val Val Val Ser Ile Val Ala Leu Ala Val 
            100                 105                 110         


Leu Ile Ile Thr Cys Val Leu Ile His Cys Cys Gln Leu Arg Lys His 
        115                 120                 125             


Cys Glu Trp Cys Arg Ala Leu Val Cys Arg His Glu Lys Pro Ser Ala 
    130                 135                 140                 


Leu Leu Lys Gly Arg Thr Ala Cys Cys His Ser Glu Thr Val Val 
145                 150                 155                 


<210>  76
<211>  5983
<212>  DNA
<213>  Mus musculus


<220>
<221>  mRNA
<222>  (1)..(5983)
<223>  epidermal growth factor receptor (EGFR), transcript variant 1

<400>  76
ctcccccagt cccgacccga gctaactaga cgtctgggca gccccagcgc aacgcgcagc     60

agcctccctc ctcttcttcc cgcactgtgc gctcctcctg ggctagggcg tctggatcga    120

gtcccggagg ctaccgcctc ccagacagac gacaggtcac ctggacgcga gcctgtgtcc    180

gggtctcgtc gttgccggcg cagtcactgg gcacaaccgt gggactccgt ctgtctcgga    240

ttaatcccgg agagccagag ccaacctctc ccggtcagag atgcgaccct cagggaccgc    300

gagaaccaca ctgctggtgt tgctgaccgc gctctgcgcc gcaggtgggg cgttggagga    360

aaagaaagtc tgccaaggca caagtaacag gctcacccaa ctgggcactt ttgaagacca    420

ctttctgagc ctgcagagga tgtacaacaa ctgtgaagtg gtccttggga acttggaaat    480

tacctatgtg caaaggaatt acgacctttc cttcttaaag accatccagg aggtggccgg    540

ctatgtcctc attgccctca acaccgtgga gagaatccct ttggagaacc tgcagatcat    600

caggggaaat gctctttatg aaaacaccta tgccttagcc atcctgtcca actatgggac    660

aaacagaact gggcttaggg aactgcccat gcggaactta caggaaatcc tgattggtgc    720

tgtgcgattc agcaacaacc ccatcctctg caatatggat actatccagt ggagggacat    780

cgtccaaaac gtctttatga gcaacatgtc aatggactta cagagccatc cgagcagttg    840

ccccaaatgt gatccaagct gtcccaatgg aagctgctgg ggaggaggag aggagaactg    900

ccagaaattg accaaaatca tctgtgccca gcaatgttcc catcgctgtc gtggcaggtc    960

ccccagtgac tgctgccaca accaatgtgc tgcggggtgt acagggcccc gagagagtga   1020

ctgtctggtc tgccaaaagt tccaagatga ggccacatgc aaagacacct gcccaccact   1080

catgctgtac aaccccacca cctatcagat ggatgtcaac cctgaaggga agtacagctt   1140

tggtgccacc tgtgtgaaga agtgcccccg aaactacgtg gtgacagatc atggctcatg   1200

tgtccgagcc tgtgggcctg actactacga agtggaagaa gatggcatcc gcaagtgtaa   1260

aaaatgtgat gggccctgtc gcaaagtttg taatggcata ggcattggtg aatttaaaga   1320

cacactctcc ataaatgcta caaacatcaa acacttcaaa tactgcactg ccatcagcgg   1380

ggaccttcac atcctgccag tggcctttaa gggggattct ttcacgcgca ctcctcctct   1440

agacccacga gaactagaaa ttctaaaaac cgtaaaggaa ataacaggct ttttgctgat   1500

tcaggcttgg cctgataact ggactgacct ccatgctttc gagaacctag aaataatacg   1560

tggcagaaca aagcaacatg gtcagttttc tttggcggtc gttggcctga acatcacatc   1620

actggggctg cgttccctca aggagatcag tgatggggat gtgatcattt ctggaaaccg   1680

aaatttgtgc tacgcaaaca caataaactg gaaaaaactc ttcgggacac ccaatcagaa   1740

aaccaaaatc atgaacaaca gagctgagaa agactgcaag gccgtgaacc acgtctgcaa   1800

tcctttatgc tcctcggaag gctgctgggg ccctgagccc agggactgtg tctcctgcca   1860

gaatgtgagc agaggcaggg agtgcgtgga gaaatgcaac atcctggagg gggaaccaag   1920

ggagtttgtg gaaaattctg aatgcatcca gtgccatcca gaatgtctgc cccaggccat   1980

gaacatcacc tgtacaggca ggggaccaga caactgcatc cagtgtgccc actacattga   2040

tggcccacac tgtgtcaaga cctgcccagc tggcatcatg ggagagaaca acactctggt   2100

ctggaagtat gcagatgcca ataatgtctg ccacctatgc cacgccaact gtacctatgg   2160

atgtgctggg ccaggtcttc aaggatgtga agtgtggcca tctgggccaa agataccatc   2220

tattgccact gggattgtgg gtggcctcct cttcatagtg gtggtggccc ttgggattgg   2280

cctattcatg cgaagacgtc acattgttcg aaagcgtaca ctacgccgcc tgcttcaaga   2340

gagagagctc gtggaacctc tcacacccag cggagaagct ccaaaccaag cccacttgag   2400

gatattaaag gaaacagaat tcaaaaagat caaagttctg ggttcgggag catttggcac   2460

agtgtataag ggtctctgga tcccagaagg tgagaaagta aaaatcccgg tggccatcaa   2520

ggagttaaga gaagccacat ctccaaaagc caacaaagaa atccttgacg aagcctatgt   2580

gatggctagt gtggacaacc ctcatgtatg ccgcctcctg ggcatctgtc tgacctccac   2640

tgtccagctc attacacagc tcatgcccta cggttgcctc ctggactacg tccgagaaca   2700

caaggacaac attggctccc agtacctcct caactggtgt gtgcagattg caaagggcat   2760

gaactacctg gaagatcggc gtttggtgca ccgtgacttg gcagccagga atgtactggt   2820

gaagacacca cagcatgtca agatcacaga ttttgggctg gccaaactgc ttggtgctga   2880

agagaaagaa tatcatgccg aggggggcaa agtgcctatc aagtggatgg ctttggaatc   2940

aattttacac cgaatttata cacaccaaag tgatgtctgg agctatggtg tcactgtgtg   3000

ggaactgatg acctttgggt ccaagcctta tgatggaatc ccagcaagtg acatctcatc   3060

catcctagag aaaggagagc gccttccaca gccacctatc tgcaccatcg atgtctacat   3120

gatcatggtc aagtgctgga tgatagatgc tgatagccgc ccaaagttcc gagagttgat   3180

tcttgaattc tccaaaatgg cccgagaccc acagcgctac cttgttatcc agggggatga   3240

aagaatgcat ttgccaagcc ctacagactc caacttttac cgagccctga tggatgaaga   3300

ggacatggag gatgtagttg atgctgatga gtatcttatc ccacagcaag gcttcttcaa   3360

cagcccgtcc acgtcgagga ctcccctctt gagttctctg agtgcaacta gcaacaattc   3420

cactgtggct tgcattaata gaaatgggag ctgccgtgtc aaagaagacg ccttcttgca   3480

gcggtacagc tccgacccca caggtgctgt aacagaggac aacatagatg acgcattcct   3540

ccctgtacct gaatatgtaa accaatctgt tcccaagagg ccagcaggct ctgtgcagaa   3600

ccctgtctat cacaatcagc ccctgcatcc agctcctgga agagacctgc attatcaaaa   3660

tccccacagc aatgcagtgg gcaaccctga gtatctcaac actgcccagc ctacctgtct   3720

cagtagtggg tttaacagcc ctgcactctg gatccagaaa ggcagtcacc aaatgagcct   3780

agacaaccct gactaccagc aggacttctt ccccaaggaa accaagccaa atggcatatt   3840

taagggcccc acagctgaaa atgcagagta cctacgggtg gcacctccaa gcagtgagtt   3900

tattggagca tgacaagaag gggcatcata ccagctataa aatgtctgga ctttctagaa   3960

tcccaggacc aactatggca gcacctccac ttctggtagc catgcccacg ctgtgtcaaa   4020

tgtcactcag actggcttta aagcataact ctgatgggct ttgtcactga gccaagaagt   4080

gggcctctct cctgatgcac tttgggaagt tgaaggtaca tcaattgatc ttcgaactgt   4140

gaagattcca caaaaaaggt atccatcgag aacattgtcc attggaacag aagtttgcct   4200

catggtgagg tacatatggg aaaaaaacag acatatggag cttatattta gggaactttg   4260

ggattcttgt ctttattgat ttgattgatg cactcttgta gtctggtaca cagagttgcc   4320

tggagccaac tgaccagaca gttggttcca ccagctctgc atcaagacac ttccgtggca   4380

agacaactaa atgtataaga agtccatgga tgccctgagc aggccacact tgtacagcat   4440

taaaccatgg cagatacaat aggataagcc actttgttac ttactggggc tgggagaaga   4500

ggaatgacgg ggtagaattt tccctcagac gtacttttta tataaatatg tccctggcac   4560

ctaacacgcg ctagtttacc agtgttttct attagacttc cttctatgtt ttctgtttca   4620

ttgttttgag ttgtaaatat gtgttcctgt cttcatttca tgaagtaaac aaacaaacaa   4680

aaaacccagt attaagtatt atcaaagaac aaccatgatt ccacattcga acccattcaa   4740

accatcagta ttgtgaccaa aagcctttaa ctaagaagga gtaaccatgc aaaaatccat   4800

agaggaattt aacccaaaat tttagtctca gcattgtgtc tgctgaggtg tgtatatgag   4860

actacgaaag tgaactactc ttcaaatcca ctttgccttc actcctctat accctaaatc   4920

tagtgtaaac cacacatgga ggataacttt tttttttaat tttaaaagtg tttattagat   4980

atgtttttct tcctggtaaa ctgcagccaa acatcagtta agagccattt ttgataaaca   5040

ctatcacaat gatctcggga tccatccttt ccgatttacc aagtgatgga tagacgtgaa   5100

ctcataaaca ctacccataa gacaaaacaa tgagtgccag acaagacatc agccaggcac   5160

cagagcacag agcaggactg ggcaatctgt tggagatatc tagaaagttc acaaaggaaa   5220

caagattgtc cactaccttg tgagatctag cagtcataaa taccagggaa atggaaagtg   5280

tgtttcctta cagcaccagg tcttcgatct tcctaatgct gtgacccttt aatacagttt   5340

gccatgttgt ggtgaccccc aaccataaaa ttatttttgt tgctacttca taactgtaaa   5400

tttgctactc ttacagacca caatgtaaat atctgatatg ctatctgata tgcaggctat   5460

ctgacagagg tcgcaacccg caggttgaga gccactgcct tcaaggcttt aatcaagaga   5520

gtagtgagct gagggcttta ctggtaagtc aggggcaagt ccaactcaat catcctcaca   5580

tactggctgc tccctcaggc ctgagaatga ggcttgcagc atcctctggt ttcctaaccg   5640

ttatccatcc ctgactctca tctctgaaaa tagatgtcat ccatgaaatt aaggagtgag   5700

aatattaagc agcatttata gagctcaaaa ttccatgtca tcaccaggaa gtgccatgtt   5760

gatcacagag aacacagagg agacatatag acagggtttt gctcaaaatt gggatataga   5820

atgagcctgt caggtaccta tcaggagcgg taatccgtga gagagaaccg ttgcaagcca   5880

ctctaactgt agcaatgaaa ccctagtatt tttgtacttt gaaatacttt cttataacaa   5940

aataaagtag caaaaaaact gttcaaaaaa aaaaaaaaaa aaa                     5983


<210>  77
<211>  1210
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(1210)
<223>  EGFR isoform 1

<400>  77

Met Arg Pro Ser Gly Thr Ala Arg Thr Thr Leu Leu Val Leu Leu Thr 
1               5                   10                  15      


Ala Leu Cys Ala Ala Gly Gly Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Arg Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Tyr Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Ala Leu 
            100                 105                 110         


Tyr Glu Asn Thr Tyr Ala Leu Ala Ile Leu Ser Asn Tyr Gly Thr Asn 
        115                 120                 125             


Arg Thr Gly Leu Arg Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


Ile Gly Ala Val Arg Phe Ser Asn Asn Pro Ile Leu Cys Asn Met Asp 
145                 150                 155                 160 


Thr Ile Gln Trp Arg Asp Ile Val Gln Asn Val Phe Met Ser Asn Met 
                165                 170                 175     


Ser Met Asp Leu Gln Ser His Pro Ser Ser Cys Pro Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Gly Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser His Arg Cys Arg 
    210                 215                 220                 


Gly Arg Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Gln Lys Phe Gln Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Pro Asp Tyr Tyr Glu Val Glu Glu 
305                 310                 315                 320 


Asp Gly Ile Arg Lys Cys Lys Lys Cys Asp Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Thr Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Tyr Cys Thr Ala Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Lys Gly Asp Ser Phe Thr Arg Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Arg Glu Leu Glu Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Asp Asn Trp Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Gly Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Arg Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Pro Asn Gln Lys Thr Lys Ile Met Asn Asn Arg Ala Glu 
                485                 490                 495     


Lys Asp Cys Lys Ala Val Asn His Val Cys Asn Pro Leu Cys Ser Ser 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Gln Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Glu Lys Cys Asn Ile Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Ile Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Asn Asn Val Cys His Leu Cys His Ala Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Ala Gly Pro Gly Leu Gln Gly Cys Glu Val Trp Pro 
625                 630                 635                 640 


Ser Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Ile Val Gly Gly Leu 
                645                 650                 655     


Leu Phe Ile Val Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg 
            660                 665                 670         


Arg His Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg 
        675                 680                 685             


Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala 
    690                 695                 700                 


His Leu Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu 
705                 710                 715                 720 


Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu 
                725                 730                 735     


Gly Glu Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala 
            740                 745                 750         


Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met 
        755                 760                 765             


Ala Ser Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu 
    770                 775                 780                 


Thr Ser Thr Val Gln Leu Ile Thr Gln Leu Met Pro Tyr Gly Cys Leu 
785                 790                 795                 800 


Leu Asp Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu 
                805                 810                 815     


Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp 
            820                 825                 830         


Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys 
        835                 840                 845             


Thr Pro Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu 
    850                 855                 860                 


Gly Ala Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile 
865                 870                 875                 880 


Lys Trp Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln 
                885                 890                 895     


Ser Asp Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe 
            900                 905                 910         


Gly Ser Lys Pro Tyr Asp Gly Ile Pro Ala Ser Asp Ile Ser Ser Ile 
        915                 920                 925             


Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp 
    930                 935                 940                 


Val Tyr Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg 
945                 950                 955                 960 


Pro Lys Phe Arg Glu Leu Ile Leu Glu Phe Ser Lys Met Ala Arg Asp 
                965                 970                 975     


Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro 
            980                 985                 990         


Ser Pro Thr Asp Ser Asn Phe Tyr  Arg Ala Leu Met Asp  Glu Glu Asp 
        995                 1000                 1005             


Met Glu  Asp Val Val Asp Ala  Asp Glu Tyr Leu Ile  Pro Gln Gln 
    1010                 1015                 1020             


Gly Phe  Phe Asn Ser Pro Ser  Thr Ser Arg Thr Pro  Leu Leu Ser 
    1025                 1030                 1035             


Ser Leu  Ser Ala Thr Ser Asn  Asn Ser Thr Val Ala  Cys Ile Asn 
    1040                 1045                 1050             


Arg Asn  Gly Ser Cys Arg Val  Lys Glu Asp Ala Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Val Thr Glu Asp  Asn Ile Asp 
    1070                 1075                 1080             


Asp Ala  Phe Leu Pro Val Pro  Glu Tyr Val Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  His Pro Ala Pro Gly  Arg Asp Leu His Tyr  Gln Asn Pro 
    1115                 1120                 1125             


His Ser  Asn Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Ala Gln 
    1130                 1135                 1140             


Pro Thr  Cys Leu Ser Ser Gly  Phe Asn Ser Pro Ala  Leu Trp Ile 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Met  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Thr Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Pro  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Pro 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


