                         SEQUENCE LISTING

<110>  Rheinische-Friedrich-Wilhelms-Univerrsitaet Bonn
 
<120>  Verfahren  zur Isolierung neuraler Zellen mit 
       Tenascin-R-Verbindungen

<130>  092185wo

<150>  EP 08164921.2
<151>  2008-09-23

<160>  10    

<170>  PatentIn version 3.3

<210>  1
<211>  4716
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (82)..(4158)

<220>
<221>  sig_peptide
<222>  (82)..(150)

<400>  1
ccttggtttc cgttgcagat tcccacaact ccatgctgtg tgctgcaggc tggtcctgaa     60

cccagatctc tggctgagag g atg ggg gca gat ggg gaa aca gtg gtt ctg      111
                        Met Gly Ala Asp Gly Glu Thr Val Val Leu         
                        1               5                   10          

aag aac atg ctc att ggc gtc aac ctg atc ctt ctg ggc tcc atg atc      159
Lys Asn Met Leu Ile Gly Val Asn Leu Ile Leu Leu Gly Ser Met Ile         
                15                  20                  25              

aag cct tca gag tgt cag ctg gag gtc acc aca gaa agg gtc cag aga      207
Lys Pro Ser Glu Cys Gln Leu Glu Val Thr Thr Glu Arg Val Gln Arg         
            30                  35                  40                  

cag tca gtg gag gag gag gga ggc att gcc aac tac aac acg tcc agc      255
Gln Ser Val Glu Glu Glu Gly Gly Ile Ala Asn Tyr Asn Thr Ser Ser         
        45                  50                  55                      

aaa gag cag cct gtg gtc ttc aac cac gtg tac aac att aac gtg ccc      303
Lys Glu Gln Pro Val Val Phe Asn His Val Tyr Asn Ile Asn Val Pro         
    60                  65                  70                          

ttg gac aac ctc tgc tcc tca ggg cta gag gcc tct gct gag cag gag      351
Leu Asp Asn Leu Cys Ser Ser Gly Leu Glu Ala Ser Ala Glu Gln Glu         
75                  80                  85                  90          

gtg agt gca gaa gac gag act ctg gca gag tac atg ggc cag acc tca      399
Val Ser Ala Glu Asp Glu Thr Leu Ala Glu Tyr Met Gly Gln Thr Ser         
                95                  100                 105             

gac cac gag agc cag gtc acc ttt aca cac agg atc aac ttc ccc aaa      447
Asp His Glu Ser Gln Val Thr Phe Thr His Arg Ile Asn Phe Pro Lys         
            110                 115                 120                 

aag gcc tgt cca tgt gcc agt tca gcc cag gtg ctg cag gag ctg ctg      495
Lys Ala Cys Pro Cys Ala Ser Ser Ala Gln Val Leu Gln Glu Leu Leu         
        125                 130                 135                     

agc cgg atc gag atg ctg gag agg gag gtg tcg gtg ctg cga gac cag      543
Ser Arg Ile Glu Met Leu Glu Arg Glu Val Ser Val Leu Arg Asp Gln         
    140                 145                 150                         

tgc aac gcc aac tgc tgc caa gaa agt gct gcc aca gga caa ctg gac      591
Cys Asn Ala Asn Cys Cys Gln Glu Ser Ala Ala Thr Gly Gln Leu Asp         
155                 160                 165                 170         

tat atc cct cac tgc agt ggc cac ggc aac ttt agc ttt gag tcc tgt      639
Tyr Ile Pro His Cys Ser Gly His Gly Asn Phe Ser Phe Glu Ser Cys         
                175                 180                 185             

ggc tgc atc tgc aac gaa ggc tgg ttt ggc aag aat tgc tcg gag ccc      687
Gly Cys Ile Cys Asn Glu Gly Trp Phe Gly Lys Asn Cys Ser Glu Pro         
            190                 195                 200                 

tac tgc ccg ctg ggt tgc tcc agc cgg ggg gtg tgt gtg gat ggc cag      735
Tyr Cys Pro Leu Gly Cys Ser Ser Arg Gly Val Cys Val Asp Gly Gln         
        205                 210                 215                     

tgc atc tgt gac agc gaa tac agc ggg gat gac tgt tcc gaa ctc cgg      783
Cys Ile Cys Asp Ser Glu Tyr Ser Gly Asp Asp Cys Ser Glu Leu Arg         
    220                 225                 230                         

tgc cca aca gac tgc agc tcc cgg ggg ctc tgc gtg gac ggg gag tgt      831
Cys Pro Thr Asp Cys Ser Ser Arg Gly Leu Cys Val Asp Gly Glu Cys         
235                 240                 245                 250         

gtc tgt gaa gag ccc tac act ggc gag gac tgc agg gaa ctg agg tgc      879
Val Cys Glu Glu Pro Tyr Thr Gly Glu Asp Cys Arg Glu Leu Arg Cys         
                255                 260                 265             

cct ggg gac tgt tcg ggg aag ggg aga tgt gcc aac ggt acc tgt tta      927
Pro Gly Asp Cys Ser Gly Lys Gly Arg Cys Ala Asn Gly Thr Cys Leu         
            270                 275                 280                 

tgc gag gag ggc tac gtt ggt gag gac tgc ggc cag cgg cag tgt ctg      975
Cys Glu Glu Gly Tyr Val Gly Glu Asp Cys Gly Gln Arg Gln Cys Leu         
        285                 290                 295                     

aat gcc tgc agt ggg cga gga caa tgt gag gag ggg ctc tgc gtc tgt     1023
Asn Ala Cys Ser Gly Arg Gly Gln Cys Glu Glu Gly Leu Cys Val Cys         
    300                 305                 310                         

gaa gag ggc tac cag ggc cct gac tgc tca gca gtt gcc cct cca gag     1071
Glu Glu Gly Tyr Gln Gly Pro Asp Cys Ser Ala Val Ala Pro Pro Glu         
315                 320                 325                 330         

gac ttg cga gtg gct ggt atc agc gac agg tcc att gag ctg gaa tgg     1119
Asp Leu Arg Val Ala Gly Ile Ser Asp Arg Ser Ile Glu Leu Glu Trp         
                335                 340                 345             

gac ggg ccg atg gca gtg acg gaa tat gtg atc tct tac cag ccg acg     1167
Asp Gly Pro Met Ala Val Thr Glu Tyr Val Ile Ser Tyr Gln Pro Thr         
            350                 355                 360                 

gcc ctg ggg ggc ctc cag ctc cag cag cgg gtg cct gga gat tgg agt     1215
Ala Leu Gly Gly Leu Gln Leu Gln Gln Arg Val Pro Gly Asp Trp Ser         
        365                 370                 375                     

ggt gtc acc atc acg gag ctg gag cca ggt ctc acc tac aac atc agc     1263
Gly Val Thr Ile Thr Glu Leu Glu Pro Gly Leu Thr Tyr Asn Ile Ser         
    380                 385                 390                         

gtc tac gct gtc att agc aac atc ctc agc ctt ccc atc act gcc aag     1311
Val Tyr Ala Val Ile Ser Asn Ile Leu Ser Leu Pro Ile Thr Ala Lys         
395                 400                 405                 410         

gtg gcc acc cat ctc tcc act cct caa ggg cta caa ttt aag acg atc     1359
Val Ala Thr His Leu Ser Thr Pro Gln Gly Leu Gln Phe Lys Thr Ile         
                415                 420                 425             

aca gag acc acc gtg gag gtg cag tgg gag ccc ttc tca ttt tcc ttc     1407
Thr Glu Thr Thr Val Glu Val Gln Trp Glu Pro Phe Ser Phe Ser Phe         
            430                 435                 440                 

gat ggg tgg gaa atc agc ttc att cca aag aac aat gaa ggg gga gtg     1455
Asp Gly Trp Glu Ile Ser Phe Ile Pro Lys Asn Asn Glu Gly Gly Val         
        445                 450                 455                     

att gct cag gtc ccc agc gat gtt acg tcc ttt aac cag aca gga cta     1503
Ile Ala Gln Val Pro Ser Asp Val Thr Ser Phe Asn Gln Thr Gly Leu         
    460                 465                 470                         

aag cct ggg gag gaa tac att gtc aat gtg gtg gct ctg aaa gaa cag     1551
Lys Pro Gly Glu Glu Tyr Ile Val Asn Val Val Ala Leu Lys Glu Gln         
475                 480                 485                 490         

gcc cgc agc ccc cct acc tcg gcc agc gtc tcc aca gtc att gac ggc     1599
Ala Arg Ser Pro Pro Thr Ser Ala Ser Val Ser Thr Val Ile Asp Gly         
                495                 500                 505             

ccc acg cag atc ctg gtt cgc gat gtc tcg gac acc gtg gct ttt gtg     1647
Pro Thr Gln Ile Leu Val Arg Asp Val Ser Asp Thr Val Ala Phe Val         
            510                 515                 520                 

gag tgg att ccc cct cga gcc aaa gtc gat ttc att ctt ttg aaa tat     1695
Glu Trp Ile Pro Pro Arg Ala Lys Val Asp Phe Ile Leu Leu Lys Tyr         
        525                 530                 535                     

ggc ctg gtg ggc ggg gaa ggt ggg agg acc acc ttc cgg ctg cag cct     1743
Gly Leu Val Gly Gly Glu Gly Gly Arg Thr Thr Phe Arg Leu Gln Pro         
    540                 545                 550                         

ccc ctg agc caa tac tca gtg cag gcc ctg cgg cct ggc tcc cga tac     1791
Pro Leu Ser Gln Tyr Ser Val Gln Ala Leu Arg Pro Gly Ser Arg Tyr         
555                 560                 565                 570         

gag gtg tca gtc agt gcc gtc cga ggg acc aac gag agc gat tct gcc     1839
Glu Val Ser Val Ser Ala Val Arg Gly Thr Asn Glu Ser Asp Ser Ala         
                575                 580                 585             

acc act cag ttc aca aca gag atc gat gcc ccc aag aac ttg cga gtt     1887
Thr Thr Gln Phe Thr Thr Glu Ile Asp Ala Pro Lys Asn Leu Arg Val         
            590                 595                 600                 

ggt tct cgc aca gca acc agc ctt gac ctc gag tgg gat aac agt gaa     1935
Gly Ser Arg Thr Ala Thr Ser Leu Asp Leu Glu Trp Asp Asn Ser Glu         
        605                 610                 615                     

gcc gaa gtt cag gag tac aag gtt gtg tac agc acc ctg gcg ggt gag     1983
Ala Glu Val Gln Glu Tyr Lys Val Val Tyr Ser Thr Leu Ala Gly Glu         
    620                 625                 630                         

caa tat cat gag gta ctg gtc ccc agg ggc att ggt cca acc acc agg     2031
Gln Tyr His Glu Val Leu Val Pro Arg Gly Ile Gly Pro Thr Thr Arg         
635                 640                 645                 650         

gcc acc ctg aca gat ctg gta cct ggc act gag tat gga gtt gga ata     2079
Ala Thr Leu Thr Asp Leu Val Pro Gly Thr Glu Tyr Gly Val Gly Ile         
                655                 660                 665             

tct gcc gtc atg aac tca cag caa agc gtg cca gcc acc atg aat gcc     2127
Ser Ala Val Met Asn Ser Gln Gln Ser Val Pro Ala Thr Met Asn Ala         
            670                 675                 680                 

agg act gaa ctt gac agt ccc cga gac ctc atg gtg aca gcc tcc tcg     2175
Arg Thr Glu Leu Asp Ser Pro Arg Asp Leu Met Val Thr Ala Ser Ser         
        685                 690                 695                     

gag acc tcc atc tcc ctc atc tgg acc aag gcc agt ggc ccc att gac     2223
Glu Thr Ser Ile Ser Leu Ile Trp Thr Lys Ala Ser Gly Pro Ile Asp         
    700                 705                 710                         

cac tac cga att acc ttt acc cca tcc tct ggg att gcc tca gaa gtc     2271
His Tyr Arg Ile Thr Phe Thr Pro Ser Ser Gly Ile Ala Ser Glu Val         
715                 720                 725                 730         

acc gta ccc aag gac agg acc tca tac aca cta aca gat cta gag cct     2319
Thr Val Pro Lys Asp Arg Thr Ser Tyr Thr Leu Thr Asp Leu Glu Pro         
                735                 740                 745             

ggg gca gag tac atc att tcc gtc act gct gag agg ggt cgg cag cag     2367
Gly Ala Glu Tyr Ile Ile Ser Val Thr Ala Glu Arg Gly Arg Gln Gln         
            750                 755                 760                 

agc ttg gag tcc act gtg gat gct ttc aca ggc ttc cgt ccc atc tct     2415
Ser Leu Glu Ser Thr Val Asp Ala Phe Thr Gly Phe Arg Pro Ile Ser         
        765                 770                 775                     

cat ctg cac ttt tct cat gtg acc tcc tcc agt gtg aac atc act tgg     2463
His Leu His Phe Ser His Val Thr Ser Ser Ser Val Asn Ile Thr Trp         
    780                 785                 790                         

agt gat cca tct ccc cca gca gac aga ctc att ctt aac tac agc ccc     2511
Ser Asp Pro Ser Pro Pro Ala Asp Arg Leu Ile Leu Asn Tyr Ser Pro         
795                 800                 805                 810         

agg gat gag gag gaa gag atg atg gag gtc tcc ctg gat gcc acc aag     2559
Arg Asp Glu Glu Glu Glu Met Met Glu Val Ser Leu Asp Ala Thr Lys         
                815                 820                 825             

agg cat gct gtc ctg atg ggc ctg caa cca gcc aca gag tat att gtg     2607
Arg His Ala Val Leu Met Gly Leu Gln Pro Ala Thr Glu Tyr Ile Val         
            830                 835                 840                 

aac ctt gtg gct gtc cat ggc aca gtg acc tct gag ccc att gtg ggc     2655
Asn Leu Val Ala Val His Gly Thr Val Thr Ser Glu Pro Ile Val Gly         
        845                 850                 855                     

tcc atc acc aca gga att gat ccc cca aaa gac atc aca att agc aat     2703
Ser Ile Thr Thr Gly Ile Asp Pro Pro Lys Asp Ile Thr Ile Ser Asn         
    860                 865                 870                         

gtg acc aag gac tca gtg atg gtc tcc tgg agc cct cct gtt gca tct     2751
Val Thr Lys Asp Ser Val Met Val Ser Trp Ser Pro Pro Val Ala Ser         
875                 880                 885                 890         

ttc gat tac tac cga gta tca tat cga ccc acc caa gtg gga cga cta     2799
Phe Asp Tyr Tyr Arg Val Ser Tyr Arg Pro Thr Gln Val Gly Arg Leu         
                895                 900                 905             

gac agc tca gtg gtg ccc aac act gtg aca gaa ttc acc atc acc aga     2847
Asp Ser Ser Val Val Pro Asn Thr Val Thr Glu Phe Thr Ile Thr Arg         
            910                 915                 920                 

ctg aac cca gct acc gaa tac gaa atc agc ctc aac agc gtg cgg ggc     2895
Leu Asn Pro Ala Thr Glu Tyr Glu Ile Ser Leu Asn Ser Val Arg Gly         
        925                 930                 935                     

agg gag gaa agc gag cgc atc tgt act ctt gtg cac aca gcc atg gac     2943
Arg Glu Glu Ser Glu Arg Ile Cys Thr Leu Val His Thr Ala Met Asp         
    940                 945                 950                         

aac cct gtg gat ctg att gct acc aat atc act cca aca gaa gcc ctg     2991
Asn Pro Val Asp Leu Ile Ala Thr Asn Ile Thr Pro Thr Glu Ala Leu         
955                 960                 965                 970         

ctg cag tgg aag gca cca gtg ggt gag gtg gag aac tac gtc att gtt     3039
Leu Gln Trp Lys Ala Pro Val Gly Glu Val Glu Asn Tyr Val Ile Val         
                975                 980                 985             

ctt aca cac ttt gca gtc gct gga gag acc atc ctt gtt gac  gga gtc    3087
Leu Thr His Phe Ala Val Ala Gly Glu Thr Ile Leu Val Asp  Gly Val        
            990                 995                 1000                

agt gag gaa  ttt cgg ctt gtt gac  ctg ctt cct agc acc  cac tat      3132
Ser Glu Glu  Phe Arg Leu Val Asp  Leu Leu Pro Ser Thr  His Tyr          
        1005                 1010                 1015                  

act gcc acc  atg tat gcc acc aat  gga cct ctc acc agt  ggc acc      3177
Thr Ala Thr  Met Tyr Ala Thr Asn  Gly Pro Leu Thr Ser  Gly Thr          
        1020                 1025                 1030                  

atc agc acc  aac ttt tct act ctc  ctg gac cct ccg gca  aac ctg      3222
Ile Ser Thr  Asn Phe Ser Thr Leu  Leu Asp Pro Pro Ala  Asn Leu          
        1035                 1040                 1045                  

aca gcc agt  gaa gtc acc aga caa  agt gcc ctg atc tcc  tgg cag      3267
Thr Ala Ser  Glu Val Thr Arg Gln  Ser Ala Leu Ile Ser  Trp Gln          
        1050                 1055                 1060                  

cct ccc agg  gca gag att gaa aat  tat gtc ttg acc tac  aaa tcc      3312
Pro Pro Arg  Ala Glu Ile Glu Asn  Tyr Val Leu Thr Tyr  Lys Ser          
        1065                 1070                 1075                  

acc gac gga  agc cgc aag gag ctg  att gtg gat gca gaa  gac acc      3357
Thr Asp Gly  Ser Arg Lys Glu Leu  Ile Val Asp Ala Glu  Asp Thr          
        1080                 1085                 1090                  

tgg att cga  ctg gag ggc ctg ttg  gag aac aca gac tac  acg gtg      3402
Trp Ile Arg  Leu Glu Gly Leu Leu  Glu Asn Thr Asp Tyr  Thr Val          
        1095                 1100                 1105                  

ctc ctg cag  gca gca cag gac acc  acg tgg agc agc atc  acc tcc      3447
Leu Leu Gln  Ala Ala Gln Asp Thr  Thr Trp Ser Ser Ile  Thr Ser          
        1110                 1115                 1120                  

acc gct ttc  acc aca gga ggc cgg  gtg ttc cct cat ccc  caa gac      3492
Thr Ala Phe  Thr Thr Gly Gly Arg  Val Phe Pro His Pro  Gln Asp          
        1125                 1130                 1135                  

tgt gcc cag  cat ttg atg aat gga  gac act ttg agt ggg  gtt tac      3537
Cys Ala Gln  His Leu Met Asn Gly  Asp Thr Leu Ser Gly  Val Tyr          
        1140                 1145                 1150                  

ccc atc ttc  ctc aat ggg gag ctg  agc cag aaa tta caa  gtg tac      3582
Pro Ile Phe  Leu Asn Gly Glu Leu  Ser Gln Lys Leu Gln  Val Tyr          
        1155                 1160                 1165                  

tgt gat atg  acc acc gac ggg ggc  ggc tgg att gta ttc  cag agg      3627
Cys Asp Met  Thr Thr Asp Gly Gly  Gly Trp Ile Val Phe  Gln Arg          
        1170                 1175                 1180                  

cgg cag aat  ggc caa act gat ttt  ttc cgg aaa tgg gct  gat tac      3672
Arg Gln Asn  Gly Gln Thr Asp Phe  Phe Arg Lys Trp Ala  Asp Tyr          
        1185                 1190                 1195                  

cgt gtt ggc  ttc ggg aac gtg gag  gat gag ttc tgg ctg  ggg ctg      3717
Arg Val Gly  Phe Gly Asn Val Glu  Asp Glu Phe Trp Leu  Gly Leu          
        1200                 1205                 1210                  

gac aat ata  cac agg atc aca tcc  cag ggc cgc tat gag  ctg cgc      3762
Asp Asn Ile  His Arg Ile Thr Ser  Gln Gly Arg Tyr Glu  Leu Arg          
        1215                 1220                 1225                  

gtg gac atg  cgg gat ggc cag gag  gcc gcc ttc gcc tcc  tac gac      3807
Val Asp Met  Arg Asp Gly Gln Glu  Ala Ala Phe Ala Ser  Tyr Asp          
        1230                 1235                 1240                  

agg ttc tct  gtc gag gac agc aga  aac ctg tac aaa ctc  cgc ata      3852
Arg Phe Ser  Val Glu Asp Ser Arg  Asn Leu Tyr Lys Leu  Arg Ile          
        1245                 1250                 1255                  

gga agc tac  aac ggc act gcg ggg  gac tcc ctc agc tat  cat caa      3897
Gly Ser Tyr  Asn Gly Thr Ala Gly  Asp Ser Leu Ser Tyr  His Gln          
        1260                 1265                 1270                  

gga cgc cct  ttc tcc aca gag gat  aga gac aat gat gtt  gca gtg      3942
Gly Arg Pro  Phe Ser Thr Glu Asp  Arg Asp Asn Asp Val  Ala Val          
        1275                 1280                 1285                  

act aac tgt  gcc atg tcg tac aag  gga gca tgg tgg tat  aag aac      3987
Thr Asn Cys  Ala Met Ser Tyr Lys  Gly Ala Trp Trp Tyr  Lys Asn          
        1290                 1295                 1300                  

tgc cac cgg  acc aac ctc aat ggg  aag tac ggg gag tcc  agg cac      4032
Cys His Arg  Thr Asn Leu Asn Gly  Lys Tyr Gly Glu Ser  Arg His          
        1305                 1310                 1315                  

agt cag ggc  atc aac tgg tac cat  tgg aaa ggc cat gag  ttc tcc      4077
Ser Gln Gly  Ile Asn Trp Tyr His  Trp Lys Gly His Glu  Phe Ser          
        1320                 1325                 1330                  

atc ccc ttt  gtg gaa atg aag atg  cgc ccc tac aac cac  cgt ctc      4122
Ile Pro Phe  Val Glu Met Lys Met  Arg Pro Tyr Asn His  Arg Leu          
        1335                 1340                 1345                  

atg gca ggg  aga aaa cgg cag tcc  tta cag ttc tga gcagtgggcg        4168
Met Ala Gly  Arg Lys Arg Gln Ser  Leu Gln Phe                           
        1350                 1355                                       

gctgcaagcc aaccaatatt ttctgtcatt tgtttgtatt ttataatatg aaacaagggg   4228

ggagggtaat agcaatgtgt tttgcaacat attaagagta tgtgaaggaa gcagggatgt   4288

cgcaggaatc cgctggctaa catctgctct tggtttctgc tgccctggag cctgaccctc   4348

agtctccatt ctccctccta cccaggcctc ctcaaccttc acctcctttc ccaccaagga   4408

ggagaagtag gaagttttct taaagggcca attcaaagcc aagtcgtggg gtgcagattg   4468

ttatggtgac aggcacacac atttttctac ccttcttctg agatgtcctc tgccttccag   4528

gtatttgtga ttttgtcaca gcctgacatg gccaggttct cacactggcc cagagaaaag   4588

agcctcagca agagagtttt gccaacaatt ccccttaaaa ggaaacagat caactacacc   4648

gcatcccaac aacccaggtt cttttccttc cttccttcct tcctcccttc cttctttcct   4708

gccttccc                                                            4716


<210>  2
<211>  1358
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Ala Asp Gly Glu Thr Val Val Leu Lys Asn Met Leu Ile Gly 
1               5                   10                  15      


Val Asn Leu Ile Leu Leu Gly Ser Met Ile Lys Pro Ser Glu Cys Gln 
            20                  25                  30          


Leu Glu Val Thr Thr Glu Arg Val Gln Arg Gln Ser Val Glu Glu Glu 
        35                  40                  45              


Gly Gly Ile Ala Asn Tyr Asn Thr Ser Ser Lys Glu Gln Pro Val Val 
    50                  55                  60                  


Phe Asn His Val Tyr Asn Ile Asn Val Pro Leu Asp Asn Leu Cys Ser 
65                  70                  75                  80  


Ser Gly Leu Glu Ala Ser Ala Glu Gln Glu Val Ser Ala Glu Asp Glu 
                85                  90                  95      


Thr Leu Ala Glu Tyr Met Gly Gln Thr Ser Asp His Glu Ser Gln Val 
            100                 105                 110         


Thr Phe Thr His Arg Ile Asn Phe Pro Lys Lys Ala Cys Pro Cys Ala 
        115                 120                 125             


Ser Ser Ala Gln Val Leu Gln Glu Leu Leu Ser Arg Ile Glu Met Leu 
    130                 135                 140                 


Glu Arg Glu Val Ser Val Leu Arg Asp Gln Cys Asn Ala Asn Cys Cys 
145                 150                 155                 160 


Gln Glu Ser Ala Ala Thr Gly Gln Leu Asp Tyr Ile Pro His Cys Ser 
                165                 170                 175     


Gly His Gly Asn Phe Ser Phe Glu Ser Cys Gly Cys Ile Cys Asn Glu 
            180                 185                 190         


Gly Trp Phe Gly Lys Asn Cys Ser Glu Pro Tyr Cys Pro Leu Gly Cys 
        195                 200                 205             


Ser Ser Arg Gly Val Cys Val Asp Gly Gln Cys Ile Cys Asp Ser Glu 
    210                 215                 220                 


Tyr Ser Gly Asp Asp Cys Ser Glu Leu Arg Cys Pro Thr Asp Cys Ser 
225                 230                 235                 240 


Ser Arg Gly Leu Cys Val Asp Gly Glu Cys Val Cys Glu Glu Pro Tyr 
                245                 250                 255     


Thr Gly Glu Asp Cys Arg Glu Leu Arg Cys Pro Gly Asp Cys Ser Gly 
            260                 265                 270         


Lys Gly Arg Cys Ala Asn Gly Thr Cys Leu Cys Glu Glu Gly Tyr Val 
        275                 280                 285             


Gly Glu Asp Cys Gly Gln Arg Gln Cys Leu Asn Ala Cys Ser Gly Arg 
    290                 295                 300                 


Gly Gln Cys Glu Glu Gly Leu Cys Val Cys Glu Glu Gly Tyr Gln Gly 
305                 310                 315                 320 


Pro Asp Cys Ser Ala Val Ala Pro Pro Glu Asp Leu Arg Val Ala Gly 
                325                 330                 335     


Ile Ser Asp Arg Ser Ile Glu Leu Glu Trp Asp Gly Pro Met Ala Val 
            340                 345                 350         


Thr Glu Tyr Val Ile Ser Tyr Gln Pro Thr Ala Leu Gly Gly Leu Gln 
        355                 360                 365             


Leu Gln Gln Arg Val Pro Gly Asp Trp Ser Gly Val Thr Ile Thr Glu 
    370                 375                 380                 


Leu Glu Pro Gly Leu Thr Tyr Asn Ile Ser Val Tyr Ala Val Ile Ser 
385                 390                 395                 400 


Asn Ile Leu Ser Leu Pro Ile Thr Ala Lys Val Ala Thr His Leu Ser 
                405                 410                 415     


Thr Pro Gln Gly Leu Gln Phe Lys Thr Ile Thr Glu Thr Thr Val Glu 
            420                 425                 430         


Val Gln Trp Glu Pro Phe Ser Phe Ser Phe Asp Gly Trp Glu Ile Ser 
        435                 440                 445             


Phe Ile Pro Lys Asn Asn Glu Gly Gly Val Ile Ala Gln Val Pro Ser 
    450                 455                 460                 


Asp Val Thr Ser Phe Asn Gln Thr Gly Leu Lys Pro Gly Glu Glu Tyr 
465                 470                 475                 480 


Ile Val Asn Val Val Ala Leu Lys Glu Gln Ala Arg Ser Pro Pro Thr 
                485                 490                 495     


Ser Ala Ser Val Ser Thr Val Ile Asp Gly Pro Thr Gln Ile Leu Val 
            500                 505                 510         


Arg Asp Val Ser Asp Thr Val Ala Phe Val Glu Trp Ile Pro Pro Arg 
        515                 520                 525             


Ala Lys Val Asp Phe Ile Leu Leu Lys Tyr Gly Leu Val Gly Gly Glu 
    530                 535                 540                 


Gly Gly Arg Thr Thr Phe Arg Leu Gln Pro Pro Leu Ser Gln Tyr Ser 
545                 550                 555                 560 


Val Gln Ala Leu Arg Pro Gly Ser Arg Tyr Glu Val Ser Val Ser Ala 
                565                 570                 575     


Val Arg Gly Thr Asn Glu Ser Asp Ser Ala Thr Thr Gln Phe Thr Thr 
            580                 585                 590         


Glu Ile Asp Ala Pro Lys Asn Leu Arg Val Gly Ser Arg Thr Ala Thr 
        595                 600                 605             


Ser Leu Asp Leu Glu Trp Asp Asn Ser Glu Ala Glu Val Gln Glu Tyr 
    610                 615                 620                 


Lys Val Val Tyr Ser Thr Leu Ala Gly Glu Gln Tyr His Glu Val Leu 
625                 630                 635                 640 


Val Pro Arg Gly Ile Gly Pro Thr Thr Arg Ala Thr Leu Thr Asp Leu 
                645                 650                 655     


Val Pro Gly Thr Glu Tyr Gly Val Gly Ile Ser Ala Val Met Asn Ser 
            660                 665                 670         


Gln Gln Ser Val Pro Ala Thr Met Asn Ala Arg Thr Glu Leu Asp Ser 
        675                 680                 685             


Pro Arg Asp Leu Met Val Thr Ala Ser Ser Glu Thr Ser Ile Ser Leu 
    690                 695                 700                 


Ile Trp Thr Lys Ala Ser Gly Pro Ile Asp His Tyr Arg Ile Thr Phe 
705                 710                 715                 720 


Thr Pro Ser Ser Gly Ile Ala Ser Glu Val Thr Val Pro Lys Asp Arg 
                725                 730                 735     


Thr Ser Tyr Thr Leu Thr Asp Leu Glu Pro Gly Ala Glu Tyr Ile Ile 
            740                 745                 750         


Ser Val Thr Ala Glu Arg Gly Arg Gln Gln Ser Leu Glu Ser Thr Val 
        755                 760                 765             


Asp Ala Phe Thr Gly Phe Arg Pro Ile Ser His Leu His Phe Ser His 
    770                 775                 780                 


Val Thr Ser Ser Ser Val Asn Ile Thr Trp Ser Asp Pro Ser Pro Pro 
785                 790                 795                 800 


Ala Asp Arg Leu Ile Leu Asn Tyr Ser Pro Arg Asp Glu Glu Glu Glu 
                805                 810                 815     


Met Met Glu Val Ser Leu Asp Ala Thr Lys Arg His Ala Val Leu Met 
            820                 825                 830         


Gly Leu Gln Pro Ala Thr Glu Tyr Ile Val Asn Leu Val Ala Val His 
        835                 840                 845             


Gly Thr Val Thr Ser Glu Pro Ile Val Gly Ser Ile Thr Thr Gly Ile 
    850                 855                 860                 


Asp Pro Pro Lys Asp Ile Thr Ile Ser Asn Val Thr Lys Asp Ser Val 
865                 870                 875                 880 


Met Val Ser Trp Ser Pro Pro Val Ala Ser Phe Asp Tyr Tyr Arg Val 
                885                 890                 895     


Ser Tyr Arg Pro Thr Gln Val Gly Arg Leu Asp Ser Ser Val Val Pro 
            900                 905                 910         


Asn Thr Val Thr Glu Phe Thr Ile Thr Arg Leu Asn Pro Ala Thr Glu 
        915                 920                 925             


Tyr Glu Ile Ser Leu Asn Ser Val Arg Gly Arg Glu Glu Ser Glu Arg 
    930                 935                 940                 


Ile Cys Thr Leu Val His Thr Ala Met Asp Asn Pro Val Asp Leu Ile 
945                 950                 955                 960 


Ala Thr Asn Ile Thr Pro Thr Glu Ala Leu Leu Gln Trp Lys Ala Pro 
                965                 970                 975     


Val Gly Glu Val Glu Asn Tyr Val Ile Val Leu Thr His Phe Ala Val 
            980                 985                 990         


Ala Gly Glu Thr Ile Leu Val Asp  Gly Val Ser Glu Glu  Phe Arg Leu 
        995                 1000                 1005             


Val Asp  Leu Leu Pro Ser Thr  His Tyr Thr Ala Thr  Met Tyr Ala 
    1010                 1015                 1020             


Thr Asn  Gly Pro Leu Thr Ser  Gly Thr Ile Ser Thr  Asn Phe Ser 
    1025                 1030                 1035             


Thr Leu  Leu Asp Pro Pro Ala  Asn Leu Thr Ala Ser  Glu Val Thr 
    1040                 1045                 1050             


Arg Gln  Ser Ala Leu Ile Ser  Trp Gln Pro Pro Arg  Ala Glu Ile 
    1055                 1060                 1065             


Glu Asn  Tyr Val Leu Thr Tyr  Lys Ser Thr Asp Gly  Ser Arg Lys 
    1070                 1075                 1080             


Glu Leu  Ile Val Asp Ala Glu  Asp Thr Trp Ile Arg  Leu Glu Gly 
    1085                 1090                 1095             


Leu Leu  Glu Asn Thr Asp Tyr  Thr Val Leu Leu Gln  Ala Ala Gln 
    1100                 1105                 1110             


Asp Thr  Thr Trp Ser Ser Ile  Thr Ser Thr Ala Phe  Thr Thr Gly 
    1115                 1120                 1125             


Gly Arg  Val Phe Pro His Pro  Gln Asp Cys Ala Gln  His Leu Met 
    1130                 1135                 1140             


Asn Gly  Asp Thr Leu Ser Gly  Val Tyr Pro Ile Phe  Leu Asn Gly 
    1145                 1150                 1155             


Glu Leu  Ser Gln Lys Leu Gln  Val Tyr Cys Asp Met  Thr Thr Asp 
    1160                 1165                 1170             


Gly Gly  Gly Trp Ile Val Phe  Gln Arg Arg Gln Asn  Gly Gln Thr 
    1175                 1180                 1185             


Asp Phe  Phe Arg Lys Trp Ala  Asp Tyr Arg Val Gly  Phe Gly Asn 
    1190                 1195                 1200             


Val Glu  Asp Glu Phe Trp Leu  Gly Leu Asp Asn Ile  His Arg Ile 
    1205                 1210                 1215             


Thr Ser  Gln Gly Arg Tyr Glu  Leu Arg Val Asp Met  Arg Asp Gly 
    1220                 1225                 1230             


Gln Glu  Ala Ala Phe Ala Ser  Tyr Asp Arg Phe Ser  Val Glu Asp 
    1235                 1240                 1245             


Ser Arg  Asn Leu Tyr Lys Leu  Arg Ile Gly Ser Tyr  Asn Gly Thr 
    1250                 1255                 1260             


Ala Gly  Asp Ser Leu Ser Tyr  His Gln Gly Arg Pro  Phe Ser Thr 
    1265                 1270                 1275             


Glu Asp  Arg Asp Asn Asp Val  Ala Val Thr Asn Cys  Ala Met Ser 
    1280                 1285                 1290             


Tyr Lys  Gly Ala Trp Trp Tyr  Lys Asn Cys His Arg  Thr Asn Leu 
    1295                 1300                 1305             


Asn Gly  Lys Tyr Gly Glu Ser  Arg His Ser Gln Gly  Ile Asn Trp 
    1310                 1315                 1320             


Tyr His  Trp Lys Gly His Glu  Phe Ser Ile Pro Phe  Val Glu Met 
    1325                 1330                 1335             


Lys Met  Arg Pro Tyr Asn His  Arg Leu Met Ala Gly  Arg Lys Arg 
    1340                 1345                 1350             


Gln Ser  Leu Gln Phe 
    1355             


<210>  3
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  3
tccatgatca agccttcaga gtg                                             23


<210>  4
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  4
gatgcagcca caggactcaa ag                                              22


<210>  5
<211>  7500
<212>  DNA
<213>  Artificial

<220>
<223>  vector pIN-III-ompA2

<400>  5
ggataaccag aagcaataaa aaatcaaatc ggatttcact atataatctc actttatcta     60

agatgaatcc gatggaagca tcctgttttc tctcaatttt tttatctaaa acccagcgtt    120

cgatgcttct ttgagcgaac gatcaaaaat aagtgccttc ccatcaaaaa aatattctca    180

acataaaaaa ctttgtgtaa tacttgtaac gctacatgga gattaactca atctagctag    240

agaggcttta cactttatgc ttccggctcg tataatgtgt ggaattgtga gcggataaca    300

atttcacaca ggaaacagct atgaccatga ttacggattc actggaactc tagataacga    360

ggcgcaaaaa atgaaaaaga cagctatcgc gattgcagtg gcactggctg gtttcgctac    420

cgtagcgcag gccgctgaat tccaagcttg gatccggctg agcaacgacg tgaacgcaat    480

gcgttccgac gttcaggctg ctaaagatga cgcagctcgt gctaaccagc gtctggacaa    540

catggctact aaataccgca agtaatagta cctgtgaagt gaaaaatggc gcacattgtg    600

cgacattttt tttgtctgcc gtttaccgct actgcgtcac gcgtaacata ttcccttgct    660

ctggttcacc attctgcgct gactctactg aaggcgcatt gctggctgcg ggagttgctc    720

cactgctcac cgaaaccgga taccctgccc gacgatacaa cgctttatcg actaacttct    780

gatctacagc cttattgtct ttaaattgcg taaagcctgc tggcagtgtg tatggcattg    840

tctgaacgtt ctgctgttct tctgccgata gtggtcgatg tacttcaaca taacgcatcc    900

cgttaggctc cacggaatat ttcaccggtt cgttgatcac tttcaccggc gttcccgtcc    960

gcacgctgga gaacaaggct ttaatatccg gtgcattcat gcgaatacac cctgaactga   1020

cgcgcaaacc gacgctgtcc ggcgcactgg taccatgaat gaggtattcg ccattaccat   1080

gcgcgaggcg cagtgcgtaa cgtcctagcg ggttatttgg tccggcagga acgactggcg   1140

gtaatttaat gccacgctcc agcgaacgct gacgaatgcc tgccgtaggc gtccaggttg   1200

ggttagggat tttctgccca acacgcgttt ccatcaccgg cgtttccagc ccctgcaatc   1260

caatacctat tggataaacc tgcacaatat tttctcccgg cggataataa taaaggcgca   1320

gctctgcaag gttggtcgac ggtcgaccgg tctcacttca acataacgca tcccgttagg   1380

ctccacggaa tatttcaccg gttcgttgat cactttcacc ggcgttcccg tccgcacgct   1440

ggagaacaag gctttaatat ccggtgcatt catgcgaata caccctgaac tgacgcgcaa   1500

accgacgctg tccggcgcac tggtaccatg aatgaggtat tcgccattac catgcgcgag   1560

gcgcagtgcg taacgtccta gcgggttatt tggtccggca ggaacgactg gcggtaattt   1620

aatgccacgc tccagcgaac gctgacgaat gcctgccgta ggcgtccagg ttgggttagg   1680

gattttctgc ccaacacgcg tttccatcac cggcgtttcc agcccctgca atccaatacc   1740

tattggataa acctgcacaa tattttctcc cggcggataa taataaaggc gcagctctgc   1800

aaggttgaca ccatcgaatg gcgcaaaacc tttcgcggta tggcatgata gcgcccggaa   1860

gagagtcaat tcagggtggt gaatgtgaaa ccagtaacgt tatacgatgt cgcagagtat   1920

gccggtgtct cttatcagac cgtttcccgc gtggtgaacc aggccagcca cgtttctgcg   1980

aaaacgcggg aaaaagtgga agcggcgatg gcggagctga attacattcc caaccgcgtg   2040

gcacaacaac tggcgggcaa acagtcgttg ctgattggcg ttgccacctc cagtctggcc   2100

ctgcacgcgc cgtcgcaaat tgtcgcggcg attaaatctc gcgccgatca actgggtgcc   2160

agcgtggtgg tgtcgatggt agaacgaagc ggcgtcgaag cctgtaaagc ggcggtgcac   2220

aatcttctcg cgcaacgcgt cagtgggctg atcattaact atccgctgga tgaccaggat   2280

gccattgctg tggaagctgc ctgcactaat gttccggcgt tatttcttga tgtctctgac   2340

cagacaccca tcaacagtat tattttctcc catgaagacg gtacgcgact gggcgtggag   2400

catctggtcg cattgggtca ccagcaaatc gcgctgttag cgggcccatt aagttctgtc   2460

tcggcgcgtc tgcgtctggc tggctggcat aaatatctca ctcgcaatca aattcagccg   2520

atagcggaac gggaaggcga ctggagtgcc atgtccggtt ttcaacaaac catgcaaatg   2580

ctgaatgagg gcatcgttcc cactgcgatg ctggttgcca acgatcagat ggcgctgggc   2640

gcaatgcgcg ccattaccga gtccgggctg cgcgttggtg cggatatctc ggtagtggga   2700

tacgacgata ccgaagacag ctcatgttat atcccgccgt taaccaccat caaacaggat   2760

tttcgcctgc tggggcaaac cagcgtggac cgcttgctgc aactctctca gggccaggcg   2820

gtgaagggca atcagctgtt gcccgtctca ctggtgaaaa gaaaaaccac cctggcgccc   2880

aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcagct ggcacgacag   2940

gtttcccgac tggaaagcgg gcagtgagcg caacgcaatt aatgtgagtt agctcactca   3000

ttaggcaccc caggctttac actttatgct aacgataatc cctgacgcgg tgcatcaggt   3060

aataacagtt gtgaaggaat agttatcgtc gtaccaggtt ttggcaccgg ggcgatagtg   3120

ttattggctt caaggatcaa cattgccgca gtatcaaaac gtcgggcaat agcctgaagg   3180

tttttatccc cttcttgcac cgtatacgtt tgattttgcc caaccagtcg gcttccggtt   3240

ggtggtagcg gataatcaac cgcccaggca gcctggatgg cgctaaaagc gccgataagc   3300

gtgagtgtaa gcaaagacgc gcgtttcatt gtaaacctcc tgtatttgcc ggagactcac   3360

gctgaaacgt cggatggcgc ttatgttcac ctgaaaccaa aacactcctg tgcaggtcag   3420

tgtaaacatt gaccatccgg caatgtgagc caaccggatg aaagctgtcc ttttagttta   3480

gctaagtgca gcggctttgg cgcgaattgc gcgaatcatc gcttccagac cttgtgaacg   3540

agatggggtg agatgttggg tgagcgccat tttttcaaac cacggacgca catcgaaatt   3600

gacaatatcc tgcggcgtca tctgatcgta gagaataaag acgaccgcaa taagcccttt   3660

cacaatcgcc gcatcgctgt cgccctgtaa ttcaataatt ccctgggcat tctggcgcat   3720

gacaatccac acctgactct gacagccctg aatgctattt tgtggacttc tgtcttcgtc   3780

gcgtaattct ggcagacgct gggggaccga tgcccttgag agccttcaac ccagtcagct   3840

ccttccggtg ggcgcggggc atgactatcg tcgccgcact tatgactgtc ttctttatca   3900

tgcaactcgt aggacaggtg ccggcagcgc tctgggtcat tttcggcgag gaccgctttc   3960

gctggagcgc gacgatgatc ggcctgtcgc ttgcggtatt cggaatcttg cacgccctcg   4020

ctcaagcctt cgtcactggt cccgccacca aacgtttcgg cgagaagcag gccattatcg   4080

ccggcatggc ggccgacgcg ctgggctacg tcttgctggc gttcgcgacg cgaggctgga   4140

tggccttccc cattatgatt cttctcgctt ccggcggcat cgggatgccc gcgttgcagg   4200

ccatgctgtc caggcaggta gatgacgacc atcagggaca gcttcaagga tcgctcgcgg   4260

ctcttaccag cctaacttcg atcactggac cgctgatcgt cacggcgatt tatgccgcct   4320

cggcgagcac atggaacggg ttggcatgga ttgtaggcgc cgccctatac cttgtctgcc   4380

tccccgcgtt gcgtcgcggt gcatggagcc gggccacctc gacctgaatg gaagccggcg   4440

gcacctcgct aacggattca ccactccaag aattggagcc aatcaattct tgcggagaac   4500

tgtgaatgcg caaaccaacc cttggcagaa catatccatc gcgtccgcca tctccagcag   4560

ccgcacgcgg cgcatctcgg gcagcgttgg gtcctggcca cgggtgcgca tgatcgtgct   4620

cctgtcgttg aggacccggc taggctggcg gggttgcctt actggttagc agaatgaatc   4680

accgatacgc gagcgaacgt gaagcgactg ctgctgcaaa acgtctgcga cctgagcaac   4740

aacatgaatg gtcttcggtt tccgtgtttc gtaaagtctg gaaacgcgga agtcagcgcc   4800

ctgcaccatt atgttccgga tctgcatcgc aggatgctgc tggctaccct gtggaacacc   4860

tacatctgta ttaacgaagc gctggcattg accctgagtg atttttctct ggtcccgccg   4920

catccatacc gccagttgtt taccctcaca acgttccagt aaccgggcat gttcatcatc   4980

agtaacccgt atcgtgagca tcctctctcg tttcatcggt atcattaccc ccatgaacag   5040

aaatccccct tacacggagg catcagtgac caaacaggaa aaaaccgccc ttaacatggc   5100

ccgctttatc agaagccaga cattaacgct tctggagaaa ctcaacgagc tggacgcgga   5160

tgaacaggca gacatctgtg aatcgcttca cgaccacgct gatgagcttt accgcagctg   5220

cctcgcgcgt ttcggtgatg acggtgaaaa cctctgacac atgcagctcc cggagacggt   5280

cacagcttgt ctgtaagcgg atgccgggag cagacaagcc cgtcagggcg cgtcagcggg   5340

tgttggcggg tgtcggggcg cagccatgac ccagtcacgt agcgatagcg gagtgtatac   5400

tggcttaact atgcggcatc agagcagatt gtactgagag tgcaccatat gcggtgtgaa   5460

ataccgcaca gatgcgtaag gagaaaatac cgcatcaggc gctcttccgc ttcctcgctc   5520

actgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg   5580

gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc   5640

cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc   5700

ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga   5760

ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc   5820

ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcat   5880

agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg   5940

cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc   6000

aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga   6060

gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact   6120

agaaggacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt   6180

ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag   6240

cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg   6300

tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa   6360

aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata   6420

tatgagtaaa cttggtctga cagttaccaa tgcttaatca gtgaggcacc tatctcagcg   6480

atctgtctat ttcgttcatc catagttgcc tgactccccg tcgtgtagat aactacgata   6540

cgggagggct taccatctgg ccccagtgct gcaatgatac cgcgagaccc acgctcaccg   6600

gctccagatt tatcagcaat aaaccagcca gccggaaggg ccgagcgcag aagtggtcct   6660

gcaactttat ccgcctccat ccagtctatt aattgttgcc gggaagctag agtaagtagt   6720

tcgccagtta atagtttgcg caacgttgtt gccattgctg caggcatcgt ggtgtcacgc   6780

tcgtcgtttg gtatggcttc attcagctcc ggttcccaac gatcaaggcg agttacatga   6840

tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt tgtcagaagt   6900

aagttggccg cagtgttatc actcatggtt atggcagcac tgcataattc tcttactgtc   6960

atgccatccg taagatgctt ttctgtgact ggtgagtact caaccaagtc attctgagaa   7020

tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa cacgggataa taccgcgcca   7080

catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg aaaactctca   7140

aggatcttac cgctgttgag atccagttcg atgtaaccca ctcgtgcacc caactgatct   7200

tcagcatctt ttactttcac cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc   7260

gcaaaaaagg gaataagggc gacacggaaa tgttgaatac tcatactctt cctttttcaa   7320

tattattgaa gcatttatca gggttattgt ctcatgagcg gatacatatt tgaatgtatt   7380

tagaaaaata aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc acctgacgtc   7440

taagaaacca ttattatcat gacattaacc tataaaaata ggcgtatcac gaggcccttt   7500


<210>  6
<211>  1358
<212>  PRT
<213>  Mus musculus

<400>  6

Met Gly Ile Asp Gly Glu Thr Val Val Leu Lys Asn Met Leu Ile Gly 
1               5                   10                  15      


Val Asn Leu Ile Leu Leu Gly Ser Met Leu Lys Pro Ser Glu Cys Arg 
            20                  25                  30          


Leu Glu Val Thr Thr Glu Arg Ala Gln Arg Gln Thr Val Glu Glu Glu 
        35                  40                  45              


Gly Gly Ala Ser Ser His Asn Thr Ser Ser Lys Glu Gln Pro Met Val 
    50                  55                  60                  


Phe Asn His Val Tyr Asn Ile Asn Val Pro Leu Glu Ser Leu Cys Ser 
65                  70                  75                  80  


Ser Gly Leu Glu Ala Ser Ala Glu Gln Asp Met Ser Ala Glu Asp Asp 
                85                  90                  95      


Thr Leu Ala Glu Tyr Ile Gly Gln Thr Ser Asp His Glu Ser Gln Val 
            100                 105                 110         


Thr Phe Thr His Lys Ile Asn Leu Pro Lys Lys Ala Cys Pro Cys Ala 
        115                 120                 125             


Ser Ser Ser Gln Val Leu Gln Glu Leu Leu Ser Arg Ile Glu Met Leu 
    130                 135                 140                 


Glu Arg Glu Val Ser Leu Leu Arg Asp Gln Cys Asn Thr Asn Cys Cys 
145                 150                 155                 160 


Gln Glu Ser Ala Ala Thr Gly Gln Leu Asp Tyr Val Pro His Cys Ser 
                165                 170                 175     


Gly His Gly Asn Phe Ser Phe Glu Ser Cys Gly Cys Ile Cys Asn Glu 
            180                 185                 190         


Gly Trp Phe Gly Lys Asn Cys Ser Glu Pro Tyr Cys Pro Leu Gly Cys 
        195                 200                 205             


Ser Ser Arg Gly Val Cys Val Asp Gly Gln Cys Ile Cys Asp Ser Glu 
    210                 215                 220                 


Tyr Ser Gly Asp Asp Cys Ser Glu Leu Arg Cys Pro Thr Asp Cys Ser 
225                 230                 235                 240 


Ser Arg Gly Leu Cys Val Asp Gly Glu Cys Val Cys Glu Glu Pro Tyr 
                245                 250                 255     


Thr Gly Glu Asp Cys Arg Glu Leu Arg Cys Pro Gly Asp Cys Ser Gly 
            260                 265                 270         


Lys Gly Gln Cys Ala Asn Gly Thr Cys Leu Cys Gln Glu Gly Tyr Ala 
        275                 280                 285             


Gly Glu Asp Cys Ser Gln Arg Arg Cys Leu Asn Ala Cys Ser Gly Arg 
    290                 295                 300                 


Gly His Cys Gln Glu Gly Leu Cys Ile Cys Glu Glu Gly Tyr Gln Gly 
305                 310                 315                 320 


Pro Asp Cys Ser Ala Val Ala Pro Pro Glu Asp Leu Arg Val Ala Gly 
                325                 330                 335     


Ile Ser Asp Arg Ser Ile Glu Leu Glu Trp Asp Gly Pro Met Ala Val 
            340                 345                 350         


Thr Glu Tyr Val Ile Ser Tyr Gln Pro Thr Ala Leu Gly Gly Leu Gln 
        355                 360                 365             


Leu Gln Gln Arg Val Pro Gly Asp Trp Ser Gly Val Thr Ile Met Glu 
    370                 375                 380                 


Leu Glu Pro Gly Leu Thr Tyr Asn Ile Ser Val Tyr Ala Val Ile Ser 
385                 390                 395                 400 


Asn Ile Leu Ser Leu Pro Ile Thr Ala Lys Val Ala Thr His Leu Ser 
                405                 410                 415     


Thr Pro Gln Gly Leu Gln Phe Lys Thr Ile Thr Glu Thr Thr Val Glu 
            420                 425                 430         


Val Gln Trp Glu Pro Phe Ser Phe Ser Phe Asp Gly Trp Glu Ile Ser 
        435                 440                 445             


Phe Ile Pro Lys Asn Asn Glu Gly Gly Val Ile Ala Gln Leu Pro Ser 
    450                 455                 460                 


Asp Val Thr Ser Phe Asn Gln Thr Gly Leu Lys Pro Gly Glu Glu Tyr 
465                 470                 475                 480 


Ile Val Asn Val Val Ala Leu Lys Glu Gln Ala Arg Ser Pro Pro Thr 
                485                 490                 495     


Ser Ala Ser Val Ser Thr Val Ile Asp Gly Pro Thr Gln Ile Leu Val 
            500                 505                 510         


Arg Asp Val Ser Asp Thr Val Ala Phe Val Glu Trp Thr Pro Pro Arg 
        515                 520                 525             


Ala Lys Val Asp Phe Ile Leu Leu Lys Tyr Gly Leu Val Gly Gly Glu 
    530                 535                 540                 


Gly Gly Lys Thr Thr Phe Arg Leu Gln Pro Pro Leu Ser Gln Tyr Ser 
545                 550                 555                 560 


Val Gln Ala Leu Arg Pro Gly Ser Arg Tyr Glu Val Ser Ile Ser Ala 
                565                 570                 575     


Val Arg Gly Thr Asn Glu Ser Glu Ala Ser Ser Thr Gln Phe Thr Thr 
            580                 585                 590         


Glu Ile Asp Ala Pro Lys Asn Leu Arg Val Gly Ser Arg Thr Ala Thr 
        595                 600                 605             


Ser Leu Asp Leu Glu Trp Asp Asn Ser Glu Ala Glu Ala Gln Glu Tyr 
    610                 615                 620                 


Lys Val Val Tyr Ser Thr Leu Ala Gly Glu Gln Tyr His Glu Val Leu 
625                 630                 635                 640 


Val Pro Lys Gly Ile Gly Pro Thr Thr Lys Thr Thr Leu Thr Asp Leu 
                645                 650                 655     


Val Pro Gly Thr Glu Tyr Gly Val Gly Ile Ser Ala Val Met Asn Ser 
            660                 665                 670         


Lys Gln Ser Ile Pro Ala Thr Met Asn Ala Arg Thr Glu Leu Asp Ser 
        675                 680                 685             


Pro Arg Asp Leu Met Val Thr Ala Ser Ser Glu Thr Ser Ile Ser Leu 
    690                 695                 700                 


Ile Trp Thr Lys Ala Ser Gly Pro Ile Asp His Tyr Arg Ile Thr Phe 
705                 710                 715                 720 


Thr Pro Ser Ser Gly Ile Ser Ser Glu Val Thr Val Pro Arg Asp Arg 
                725                 730                 735     


Thr Ser Tyr Thr Leu Thr Asp Leu Glu Pro Gly Ala Glu Tyr Ile Ile 
            740                 745                 750         


Ser Ile Thr Ala Glu Arg Gly Arg Gln Gln Ser Leu Glu Ser Thr Val 
        755                 760                 765             


Asp Ala Phe Thr Gly Phe Arg Pro Ile Ser His Leu His Phe Ser His 
    770                 775                 780                 


Val Thr Ser Ser Ser Val Asn Ile Thr Trp Ser Asp Pro Ser Pro Pro 
785                 790                 795                 800 


Ala Asp Arg Leu Ile Leu Asn Tyr Ser Pro Arg Asp Lys Glu Glu Asp 
                805                 810                 815     


Met Leu Glu Val Leu Leu Asp Ala Thr Lys Arg His Ala Val Leu Met 
            820                 825                 830         


Gly Leu Gln Pro Ala Thr Glu Tyr Ile Val Asn Leu Val Ala Val His 
        835                 840                 845             


Gly Thr Val Thr Ser Glu Pro Ile Val Gly Ser Ile Thr Thr Gly Ile 
    850                 855                 860                 


Asp Pro Pro Lys Asn Ile Thr Ile Ser Asn Val Thr Lys Asp Ser Leu 
865                 870                 875                 880 


Thr Val Ser Trp Ser Ser Pro Val Ala Pro Phe Asp Tyr Tyr Arg Val 
                885                 890                 895     


Ser Tyr Arg Pro Thr Gln Val Gly Arg Leu Asp Ser Ser Val Val Pro 
            900                 905                 910         


Asn Thr Val Thr Glu Phe Ala Ile Thr Arg Leu Tyr Pro Ala Thr Glu 
        915                 920                 925             


Tyr Glu Ile Ser Leu Asn Ser Val Arg Gly Arg Glu Glu Ser Glu Arg 
    930                 935                 940                 


Ile Cys Thr Leu Val His Thr Ala Met Asp Ser Pro Met Asp Leu Ile 
945                 950                 955                 960 


Ala Thr Asn Ile Thr Pro Thr Glu Ala Leu Leu Gln Trp Lys Ala Pro 
                965                 970                 975     


Met Gly Glu Val Glu Asn Tyr Val Ile Val Leu Thr His Phe Ala Ile 
            980                 985                 990         


Ala Gly Glu Thr Ile Leu Val Asp  Gly Val Ser Glu Glu  Phe Gln Leu 
        995                 1000                 1005             


Val Asp  Leu Leu Pro Ser Thr  His Tyr Thr Val Thr  Met Tyr Ala 
    1010                 1015                 1020             


Thr Ser  Gly Pro Leu Met Ser  Gly Thr Ile Ala Thr  Asn Phe Ser 
    1025                 1030                 1035             


Thr Leu  Leu Asp Pro Pro Asp  Asn Leu Thr Ala Ser  Glu Val Thr 
    1040                 1045                 1050             


Arg Gln  Ser Ala Leu Ile Ser  Trp Gln Pro Pro Arg  Ala Ala Ile 
    1055                 1060                 1065             


Glu Asn  Tyr Val Leu Thr Tyr  Lys Ser Thr Asp Gly  Ser Arg Lys 
    1070                 1075                 1080             


Glu Leu  Ile Val Asp Ala Glu  Asp Thr Trp Ile Arg  Leu Glu Gly 
    1085                 1090                 1095             


Leu Ser  Glu Asn Thr Asp Tyr  Thr Val Leu Leu Gln  Ala Ala Gln 
    1100                 1105                 1110             


Glu Ala  Thr Arg Ser Ser Leu  Thr Ser Thr Val Phe  Thr Thr Gly 
    1115                 1120                 1125             


Gly Arg  Val Phe Ser His Pro  Gln Asp Cys Ala Gln  His Leu Met 
    1130                 1135                 1140             


Asn Gly  Asp Thr Leu Ser Gly  Val Tyr Thr Ile Phe  Leu Asn Gly 
    1145                 1150                 1155             


Glu Leu  Ser His Lys Leu Gln  Val Tyr Cys Asp Met  Thr Thr Asp 
    1160                 1165                 1170             


Gly Gly  Gly Trp Ile Val Phe  Gln Arg Arg Gln Asn  Gly Gln Thr 
    1175                 1180                 1185             


Asp Phe  Phe Arg Lys Trp Ala  Asp Tyr Arg Val Gly  Phe Gly Asn 
    1190                 1195                 1200             


Leu Glu  Asp Glu Phe Trp Leu  Gly Leu Asp Asn Ile  His Arg Ile 
    1205                 1210                 1215             


Thr Ala  Gln Gly Arg Tyr Glu  Leu Arg Val Asp Met  Arg Asp Gly 
    1220                 1225                 1230             


Gln Glu  Ala Val Phe Ala Tyr  Tyr Asp Lys Phe Ala  Val Glu Asp 
    1235                 1240                 1245             


Ser Arg  Ser Leu Tyr Lys Ile  Arg Ile Gly Ser Tyr  Asn Gly Thr 
    1250                 1255                 1260             


Ala Gly  Asp Ser Leu Ser Tyr  His Gln Gly Arg Pro  Phe Ser Thr 
    1265                 1270                 1275             


Glu Asp  Arg Asp Asn Asp Val  Ala Val Thr Asn Cys  Ala Met Ser 
    1280                 1285                 1290             


Tyr Lys  Gly Ala Trp Trp Tyr  Lys Asn Cys His Arg  Thr Asn Leu 
    1295                 1300                 1305             


Asn Gly  Lys Tyr Gly Glu Ser  Arg His Ser Gln Gly  Ile Asn Trp 
    1310                 1315                 1320             


Tyr His  Trp Lys Gly His Glu  Phe Ser Ile Pro Phe  Val Glu Met 
    1325                 1330                 1335             


Lys Met  Arg Pro Tyr Ile His  Arg Leu Thr Ala Gly  Arg Lys Arg 
    1340                 1345                 1350             


Arg Ala  Leu Lys Phe 
    1355             


<210>  7
<211>  1356
<212>  PRT
<213>  Rattus norvegicus

<400>  7

Met Gly Ile Glu Gly Glu Thr Val Val Leu Lys Asn Met Leu Ile Gly 
1               5                   10                  15      


Val Asn Leu Ile Leu Leu Gly Ser Met Leu Lys Pro Ser Glu Cys Arg 
            20                  25                  30          


Leu Glu Val Thr Thr Glu Arg Val Gln Arg Gln Thr Val Glu Glu Glu 
        35                  40                  45              


Gly Gly Ala Ser Ser Tyr Asn Thr Ser Ser Lys Glu Gln Pro Met Val 
    50                  55                  60                  


Phe Asn His Val Tyr Asn Ile Asn Val Pro Leu Glu Ser Leu Cys Ser 
65                  70                  75                  80  


Ser Gly Leu Glu Ala Ser Ala Glu Gln Asp Val Ser Ala Glu Asp Asp 
                85                  90                  95      


Thr Leu Ala Glu Tyr Thr Gly Gln Thr Ser Asp His Glu Ser Gln Val 
            100                 105                 110         


Thr Phe Thr His Lys Ile Asn Leu Pro Lys Lys Ala Cys Pro Cys Ala 
        115                 120                 125             


Ser Ser Ala Gln Val Leu Gln Glu Leu Leu Ser Arg Ile Glu Met Leu 
    130                 135                 140                 


Glu Arg Glu Val Ser Val Leu Arg Asp Gln Cys Asn Thr Asn Cys Cys 
145                 150                 155                 160 


Gln Glu Ser Ala Ala Thr Gly Gln Leu Asp Tyr Val Pro His Cys Ser 
                165                 170                 175     


Gly His Gly Asn Phe Ser Phe Glu Ser Cys Gly Cys Ile Cys Asn Glu 
            180                 185                 190         


Gly Trp Phe Gly Lys Asn Cys Ser Glu Pro Tyr Cys Pro Leu Gly Cys 
        195                 200                 205             


Ser Ser Arg Gly Val Cys Val Asp Gly Gln Cys Ile Cys Asp Ser Glu 
    210                 215                 220                 


Tyr Ser Gly Asp Asp Cys Ser Glu Leu Arg Cys Pro Thr Asp Cys Ser 
225                 230                 235                 240 


Ser Arg Gly Leu Cys Val Asp Gly Glu Cys Val Cys Glu Glu Pro Tyr 
                245                 250                 255     


Thr Gly Glu Asp Cys Arg Glu Leu Arg Cys Pro Gly Asp Cys Ser Gly 
            260                 265                 270         


Lys Gly Gln Cys Ala Asn Gly Thr Cys Leu Cys Gln Glu Gly Tyr Ala 
        275                 280                 285             


Gly Glu Asp Cys Ser Gln Arg Arg Cys Leu Asn Ala Cys Ser Gly Arg 
    290                 295                 300                 


Gly His Cys Gln Glu Gly Leu Cys Ile Cys Glu Glu Gly Tyr Gln Gly 
305                 310                 315                 320 


Pro Asp Cys Ser Ala Val Thr Pro Pro Glu Asp Leu Arg Val Ala Gly 
                325                 330                 335     


Ile Ser Asp Arg Ser Ile Glu Leu Glu Trp Asp Gly Pro Met Ala Val 
            340                 345                 350         


Thr Glu Tyr Val Ile Ser Tyr Gln Pro Ser Leu Gly Gly Leu Gln Leu 
        355                 360                 365             


Gln Gln Arg Val Pro Gly Asp Trp Ser Gly Val Thr Ile Thr Glu Leu 
    370                 375                 380                 


Glu Pro Gly Leu Thr Tyr Asn Ile Ser Val Tyr Ala Val Ile Ser Asn 
385                 390                 395                 400 


Ile Leu Ser Leu Pro Ile Thr Ala Lys Val Ala Thr His Leu Ser Thr 
                405                 410                 415     


Pro Gln Gly Leu Gln Phe Lys Thr Ile Thr Glu Thr Thr Val Glu Val 
            420                 425                 430         


Gln Trp Glu Pro Phe Ser Phe Ser Phe Asp Gly Trp Glu Ile Ser Phe 
        435                 440                 445             


Thr Pro Lys Asn Asn Glu Gly Gly Val Ile Ala Gln Leu Pro Ser Asp 
    450                 455                 460                 


Val Thr Ser Phe Asn Gln Thr Gly Leu Lys Pro Gly Glu Glu Tyr Ile 
465                 470                 475                 480 


Val Asn Val Val Ala Leu Lys Glu Gln Ala Arg Gly Pro Pro Thr Ser 
                485                 490                 495     


Ala Ser Val Ser Thr Val Ile Asp Gly Pro Thr Gln Ile Leu Val Arg 
            500                 505                 510         


Asp Val Ser Asp Thr Val Ala Phe Val Glu Trp Thr Pro Pro Arg Ala 
        515                 520                 525             


Lys Val Asp Phe Ile Leu Leu Lys Tyr Gly Leu Val Gly Gly Glu Gly 
    530                 535                 540                 


Gly Lys Thr Thr Phe Arg Leu Gln Pro Pro Leu Ser Gln Tyr Ser Val 
545                 550                 555                 560 


Gln Ala Leu Arg Pro Gly Ser Arg Tyr Glu Val Ser Ile Ser Ala Val 
                565                 570                 575     


Arg Gly Thr Asn Glu Ser Asp Ala Ser Ser Thr Gln Phe Thr Thr Glu 
            580                 585                 590         


Ile Asp Ala Pro Lys Asn Leu Arg Val Gly Ser Arg Thr Ala Thr Ser 
        595                 600                 605             


Leu Asp Leu Glu Trp Asp Asn Ser Glu Ala Glu Ala Gln Glu Tyr Lys 
    610                 615                 620                 


Val Val Tyr Ser Thr Leu Ala Gly Glu Gln Tyr His Glu Val Leu Val 
625                 630                 635                 640 


Pro Lys Gly Ile Gly Pro Thr Thr Lys Thr Thr Leu Thr Asp Leu Val 
                645                 650                 655     


Pro Gly Thr Glu Tyr Gly Val Gly Ile Ser Ala Val Met Asn Ser Lys 
            660                 665                 670         


Gln Ser Ile Pro Ala Thr Met Asn Ala Arg Thr Glu Leu Asp Ser Pro 
        675                 680                 685             


Arg Asp Leu Met Val Thr Ala Ser Ser Glu Thr Ser Ile Ser Leu Ile 
    690                 695                 700                 


Trp Thr Lys Ala Ser Gly Pro Ile Asp His Tyr Arg Ile Thr Phe Thr 
705                 710                 715                 720 


Pro Ser Ser Gly Ile Ser Ser Glu Val Thr Val Pro Arg Asp Arg Thr 
                725                 730                 735     


Ser Tyr Thr Leu Thr Asp Leu Glu Pro Gly Ala Glu Tyr Ile Ile Ser 
            740                 745                 750         


Ile Thr Ala Glu Arg Gly Arg Gln Gln Ser Leu Glu Ser Thr Val Asp 
        755                 760                 765             


Ala Phe Thr Gly Phe Arg Pro Ile Ser His Leu His Phe Ser His Val 
    770                 775                 780                 


Thr Ser Ser Ser Val Asn Ile Thr Trp Ser Asp Pro Ser Pro Pro Ala 
785                 790                 795                 800 


Asp Arg Leu Ile Leu Asn Tyr Ser Pro Arg Asp Glu Glu Glu Glu Met 
                805                 810                 815     


Met Glu Val Leu Leu Asp Ala Thr Lys Arg His Ala Val Leu Met Gly 
            820                 825                 830         


Leu Gln Pro Ala Thr Glu Tyr Ile Val Asn Leu Val Ala Val His Gly 
        835                 840                 845             


Thr Val Thr Ser Glu Pro Ile Val Gly Ser Ile Thr Thr Gly Ile Asp 
    850                 855                 860                 


Pro Pro Lys Asn Ile Thr Ile Ser Asn Val Thr Lys Asp Ser Leu Thr 
865                 870                 875                 880 


Val Ser Trp Ser Pro Pro Val Ala Pro Phe Asp Tyr Tyr Glu Tyr Pro 
                885                 890                 895     


Ile Asp His Pro Ser Gly Arg Leu Asp Ser Ser Val Val Pro Asn Thr 
            900                 905                 910         


Val Thr Glu Phe Thr Ile Thr Arg Leu Tyr Pro Ala Ser Gln Tyr Glu 
        915                 920                 925             


Ile Ser Leu Asn Ser Val Arg Gly Arg Glu Glu Ser Glu Arg Ile Cys 
    930                 935                 940                 


Thr Leu Val His Thr Ala Met Asp Ser Pro Met Asp Leu Ile Ala Thr 
945                 950                 955                 960 


Asn Ile Thr Pro Thr Glu Ala Leu Leu Gln Trp Lys Ala Pro Met Gly 
                965                 970                 975     


Glu Val Glu Asn Tyr Val Ile Val Leu Thr His Phe Ala Met Ala Gly 
            980                 985                 990         


Glu Thr Ile Leu Val Asp Gly Val  Ser Glu Glu Phe Gln  Leu Val Asp 
        995                 1000                 1005             


Leu Leu  Pro Arg Thr His Tyr  Thr Val Thr Met Tyr  Ala Thr Ser 
    1010                 1015                 1020             


Gly Pro  Leu Val Ser Gly Thr  Ile Ala Thr Asn Phe  Ser Thr Leu 
    1025                 1030                 1035             


Leu Asp  Pro Pro Ala Asn Leu  Thr Ala Ser Glu Val  Thr Arg Gln 
    1040                 1045                 1050             


Ser Ala  Leu Ile Ser Trp Gln  Pro Pro Arg Ala Ala  Ile Glu Asn 
    1055                 1060                 1065             


Tyr Val  Leu Thr Tyr Lys Ser  Thr Asp Gly Ser Arg  Lys Glu Leu 
    1070                 1075                 1080             


Ile Val  Asp Ala Glu Asp Thr  Trp Ile Arg Leu Glu  Gly Leu Ser 
    1085                 1090                 1095             


Glu Asn  Thr Asp Tyr Thr Val  Leu Leu Gln Ala Ala  Gln Glu Ala 
    1100                 1105                 1110             


Thr Arg  Ser Ser Leu Thr Ser  Thr Ile Phe Thr Thr  Gly Gly Arg 
    1115                 1120                 1125             


Val Phe  Ser His Pro Gln Asp  Cys Ala Gln His Leu  Met Asn Gly 
    1130                 1135                 1140             


Asp Thr  Leu Ser Gly Val Tyr  Thr Ile Phe Leu Asn  Gly Glu Leu 
    1145                 1150                 1155             


Ser His  Lys Leu Gln Val Tyr  Cys Asp Met Thr Thr  Asp Gly Gly 
    1160                 1165                 1170             


Gly Trp  Ile Val Phe Gln Arg  Arg Gln Asn Gly Gln  Thr Asp Phe 
    1175                 1180                 1185             


Phe Arg  Lys Trp Ala Asp Tyr  Arg Val Gly Phe Gly  Asn Leu Glu 
    1190                 1195                 1200             


Asp Glu  Phe Trp Leu Gly Leu  Asp Asn Tyr His Arg  Ile Thr Ala 
    1205                 1210                 1215             


Gln Gly  Arg Tyr Glu Leu Arg  Val Asp Met Arg Asp  Gly Gln Glu 
    1220                 1225                 1230             


Ala Val  Phe Ala Tyr Tyr Asp  Lys Phe Ala Val Glu  Asp Ser Arg 
    1235                 1240                 1245             


Ser Leu  Tyr Lys Leu Arg Ile  Gly Gly Tyr Asn Gly  Thr Ala Gly 
    1250                 1255                 1260             


Asp Ser  Leu Ser Tyr His Gln  Gly Arg Pro Phe Ser  Thr Glu Asp 
    1265                 1270                 1275             


Arg Asp  Asn Asp Val Ala Val  Thr Asn Cys Ala Met  Ser Tyr Lys 
    1280                 1285                 1290             


Gly Ala  Trp Trp Tyr Lys Asn  Cys His Arg Thr Asn  Leu Asn Gly 
    1295                 1300                 1305             


Lys Tyr  Gly Glu Ser Arg His  Ser Gln Gly Ile Asn  Trp Tyr His 
    1310                 1315                 1320             


Trp Lys  Gly His Glu Phe Ser  Ile Pro Phe Val Glu  Met Lys Met 
    1325                 1330                 1335             


Arg Pro  Tyr Ile His Arg Leu  Thr Ala Gly Arg Lys  Arg Arg Ala 
    1340                 1345                 1350             


Leu Lys  Phe 
    1355     


<210>  8
<211>  1334
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ile Lys Pro Ser Glu Cys Gln Leu Glu Val Thr Thr Glu Arg Val 
1               5                   10                  15      


Gln Arg Gln Ser Val Glu Glu Glu Gly Gly Ile Ala Asn Tyr Asn Thr 
            20                  25                  30          


Ser Ser Lys Glu Gln Pro Val Val Phe Asn His Val Tyr Asn Ile Asn 
        35                  40                  45              


Val Pro Leu Asp Asn Leu Cys Ser Ser Gly Leu Glu Ala Ser Ala Glu 
    50                  55                  60                  


Gln Glu Val Ser Ala Glu Asp Glu Thr Leu Ala Glu Tyr Met Gly Gln 
65                  70                  75                  80  


Thr Ser Asp His Glu Ser Gln Val Thr Phe Thr His Arg Ile Asn Phe 
                85                  90                  95      


Pro Lys Lys Ala Cys Pro Cys Ala Ser Ser Ala Gln Val Leu Gln Glu 
            100                 105                 110         


Leu Leu Ser Arg Ile Glu Met Leu Glu Arg Glu Val Ser Val Leu Arg 
        115                 120                 125             


Asp Gln Cys Asn Ala Asn Cys Cys Gln Glu Ser Ala Ala Thr Gly Gln 
    130                 135                 140                 


Leu Asp Tyr Ile Pro His Cys Ser Gly His Gly Asn Phe Ser Phe Glu 
145                 150                 155                 160 


Ser Cys Gly Cys Ile Cys Asn Glu Gly Trp Phe Gly Lys Asn Cys Ser 
                165                 170                 175     


Glu Pro Tyr Cys Pro Leu Gly Cys Ser Ser Arg Gly Val Cys Val Asp 
            180                 185                 190         


Gly Gln Cys Ile Cys Asp Ser Glu Tyr Ser Gly Asp Asp Cys Ser Glu 
        195                 200                 205             


Leu Arg Cys Pro Thr Asp Cys Ser Ser Arg Gly Leu Cys Val Asp Gly 
    210                 215                 220                 


Glu Cys Val Cys Glu Glu Pro Tyr Thr Gly Glu Asp Cys Arg Glu Leu 
225                 230                 235                 240 


Arg Cys Pro Gly Asp Cys Ser Gly Lys Gly Arg Cys Ala Asn Gly Thr 
                245                 250                 255     


Cys Leu Cys Glu Glu Gly Tyr Val Gly Glu Asp Cys Gly Gln Arg Gln 
            260                 265                 270         


Cys Leu Asn Ala Cys Ser Gly Arg Gly Gln Cys Glu Glu Gly Leu Cys 
        275                 280                 285             


Val Cys Glu Glu Gly Tyr Gln Gly Pro Asp Cys Ser Ala Val Ala Pro 
    290                 295                 300                 


Pro Glu Asp Leu Arg Val Ala Gly Ile Ser Asp Arg Ser Ile Glu Leu 
305                 310                 315                 320 


Glu Trp Asp Gly Pro Met Ala Val Thr Glu Tyr Val Ile Ser Tyr Gln 
                325                 330                 335     


Pro Thr Ala Leu Gly Gly Leu Gln Leu Gln Gln Arg Val Pro Gly Asp 
            340                 345                 350         


Trp Ser Gly Val Thr Ile Thr Glu Leu Glu Pro Gly Leu Thr Tyr Asn 
        355                 360                 365             


Ile Ser Val Tyr Ala Val Ile Ser Asn Ile Leu Ser Leu Pro Ile Thr 
    370                 375                 380                 


Ala Lys Val Ala Thr His Leu Ser Thr Pro Gln Gly Leu Gln Phe Lys 
385                 390                 395                 400 


Thr Ile Thr Glu Thr Thr Val Glu Val Gln Trp Glu Pro Phe Ser Phe 
                405                 410                 415     


Ser Phe Asp Gly Trp Glu Ile Ser Phe Ile Pro Lys Asn Asn Glu Gly 
            420                 425                 430         


Gly Val Ile Ala Gln Val Pro Ser Asp Val Thr Ser Phe Asn Gln Thr 
        435                 440                 445             


Gly Leu Lys Pro Gly Glu Glu Tyr Ile Val Asn Val Val Ala Leu Lys 
    450                 455                 460                 


Glu Gln Ala Arg Ser Pro Pro Thr Ser Ala Ser Val Ser Thr Val Ile 
465                 470                 475                 480 


Asp Gly Pro Thr Gln Ile Leu Val Arg Asp Val Ser Asp Thr Val Ala 
                485                 490                 495     


Phe Val Glu Trp Ile Pro Pro Arg Ala Lys Val Asp Phe Ile Leu Leu 
            500                 505                 510         


Lys Tyr Gly Leu Val Gly Gly Glu Gly Gly Arg Thr Thr Phe Arg Leu 
        515                 520                 525             


Gln Pro Pro Leu Ser Gln Tyr Ser Val Gln Ala Leu Arg Pro Gly Ser 
    530                 535                 540                 


Arg Tyr Glu Val Ser Val Ser Ala Val Arg Gly Thr Asn Glu Ser Asp 
545                 550                 555                 560 


Ser Ala Thr Thr Gln Phe Thr Thr Glu Ile Asp Ala Pro Lys Asn Leu 
                565                 570                 575     


Arg Val Gly Ser Arg Thr Ala Thr Ser Leu Asp Leu Glu Trp Asp Asn 
            580                 585                 590         


Ser Glu Ala Glu Val Gln Glu Tyr Lys Val Val Tyr Ser Thr Leu Ala 
        595                 600                 605             


Gly Glu Gln Tyr His Glu Val Leu Val Pro Arg Gly Ile Gly Pro Thr 
    610                 615                 620                 


Thr Arg Ala Thr Leu Thr Asp Leu Val Pro Gly Thr Glu Tyr Gly Val 
625                 630                 635                 640 


Gly Ile Ser Ala Val Met Asn Ser Gln Gln Ser Val Pro Ala Thr Met 
                645                 650                 655     


Asn Ala Arg Thr Glu Leu Asp Ser Pro Arg Asp Leu Met Val Thr Ala 
            660                 665                 670         


Ser Ser Glu Thr Ser Ile Ser Leu Ile Trp Thr Lys Ala Ser Gly Pro 
        675                 680                 685             


Ile Asp His Tyr Arg Ile Thr Phe Thr Pro Ser Ser Gly Ile Ala Ser 
    690                 695                 700                 


Glu Val Thr Val Pro Lys Asp Arg Thr Ser Tyr Thr Leu Thr Asp Leu 
705                 710                 715                 720 


Glu Pro Gly Ala Glu Tyr Ile Ile Ser Val Thr Ala Glu Arg Gly Arg 
                725                 730                 735     


Gln Gln Ser Leu Glu Ser Thr Val Asp Ala Phe Thr Gly Phe Arg Pro 
            740                 745                 750         


Ile Ser His Leu His Phe Ser His Val Thr Ser Ser Ser Val Asn Ile 
        755                 760                 765             


Thr Trp Ser Asp Pro Ser Pro Pro Ala Asp Arg Leu Ile Leu Asn Tyr 
    770                 775                 780                 


Ser Pro Arg Asp Glu Glu Glu Glu Met Met Glu Val Ser Leu Asp Ala 
785                 790                 795                 800 


Thr Lys Arg His Ala Val Leu Met Gly Leu Gln Pro Ala Thr Glu Tyr 
                805                 810                 815     


Ile Val Asn Leu Val Ala Val His Gly Thr Val Thr Ser Glu Pro Ile 
            820                 825                 830         


Val Gly Ser Ile Thr Thr Gly Ile Asp Pro Pro Lys Asp Ile Thr Ile 
        835                 840                 845             


Ser Asn Val Thr Lys Asp Ser Val Met Val Ser Trp Ser Pro Pro Val 
    850                 855                 860                 


Ala Ser Phe Asp Tyr Tyr Arg Val Ser Tyr Arg Pro Thr Gln Val Gly 
865                 870                 875                 880 


Arg Leu Asp Ser Ser Val Val Pro Asn Thr Val Thr Glu Phe Thr Ile 
                885                 890                 895     


Thr Arg Leu Asn Pro Ala Thr Glu Tyr Glu Ile Ser Leu Asn Ser Val 
            900                 905                 910         


Arg Gly Arg Glu Glu Ser Glu Arg Ile Cys Thr Leu Val His Thr Ala 
        915                 920                 925             


Met Asp Asn Pro Val Asp Leu Ile Ala Thr Asn Ile Thr Pro Thr Glu 
    930                 935                 940                 


Ala Leu Leu Gln Trp Lys Ala Pro Val Gly Glu Val Glu Asn Tyr Val 
945                 950                 955                 960 


Ile Val Leu Thr His Phe Ala Val Ala Gly Glu Thr Ile Leu Val Asp 
                965                 970                 975     


Gly Val Ser Glu Glu Phe Arg Leu Val Asp Leu Leu Pro Ser Thr His 
            980                 985                 990         


Tyr Thr Ala Thr Met Tyr Ala Thr  Asn Gly Pro Leu Thr  Ser Gly Thr 
        995                 1000                 1005             


Ile Ser  Thr Asn Phe Ser Thr  Leu Leu Asp Pro Pro  Ala Asn Leu 
    1010                 1015                 1020             


Thr Ala  Ser Glu Val Thr Arg  Gln Ser Ala Leu Ile  Ser Trp Gln 
    1025                 1030                 1035             


Pro Pro  Arg Ala Glu Ile Glu  Asn Tyr Val Leu Thr  Tyr Lys Ser 
    1040                 1045                 1050             


Thr Asp  Gly Ser Arg Lys Glu  Leu Ile Val Asp Ala  Glu Asp Thr 
    1055                 1060                 1065             


Trp Ile  Arg Leu Glu Gly Leu  Leu Glu Asn Thr Asp  Tyr Thr Val 
    1070                 1075                 1080             


Leu Leu  Gln Ala Ala Gln Asp  Thr Thr Trp Ser Ser  Ile Thr Ser 
    1085                 1090                 1095             


Thr Ala  Phe Thr Thr Gly Gly  Arg Val Phe Pro His  Pro Gln Asp 
    1100                 1105                 1110             


Cys Ala  Gln His Leu Met Asn  Gly Asp Thr Leu Ser  Gly Val Tyr 
    1115                 1120                 1125             


Pro Ile  Phe Leu Asn Gly Glu  Leu Ser Gln Lys Leu  Gln Val Tyr 
    1130                 1135                 1140             


Cys Asp  Met Thr Thr Asp Gly  Gly Gly Trp Ile Val  Phe Gln Arg 
    1145                 1150                 1155             


Arg Gln  Asn Gly Gln Thr Asp  Phe Phe Arg Lys Trp  Ala Asp Tyr 
    1160                 1165                 1170             


Arg Val  Gly Phe Gly Asn Val  Glu Asp Glu Phe Trp  Leu Gly Leu 
    1175                 1180                 1185             


Asp Asn  Ile His Arg Ile Thr  Ser Gln Gly Arg Tyr  Glu Leu Arg 
    1190                 1195                 1200             


Val Asp  Met Arg Asp Gly Gln  Glu Ala Ala Phe Ala  Ser Tyr Asp 
    1205                 1210                 1215             


Arg Phe  Ser Val Glu Asp Ser  Arg Asn Leu Tyr Lys  Leu Arg Ile 
    1220                 1225                 1230             


Gly Ser  Tyr Asn Gly Thr Ala  Gly Asp Ser Leu Ser  Tyr His Gln 
    1235                 1240                 1245             


Gly Arg  Pro Phe Ser Thr Glu  Asp Arg Asp Asn Asp  Val Ala Val 
    1250                 1255                 1260             


Thr Asn  Cys Ala Met Ser Tyr  Lys Gly Ala Trp Trp  Tyr Lys Asn 
    1265                 1270                 1275             


Cys His  Arg Thr Asn Leu Asn  Gly Lys Tyr Gly Glu  Ser Arg His 
    1280                 1285                 1290             


Ser Gln  Gly Ile Asn Trp Tyr  His Trp Lys Gly His  Glu Phe Ser 
    1295                 1300                 1305             


Ile Pro  Phe Val Glu Met Lys  Met Arg Pro Tyr Asn  His Arg Leu 
    1310                 1315                 1320             


Met Ala  Gly Arg Lys Arg Gln  Ser Leu Gln Phe 
    1325                 1330                 


<210>  9
<211>  1353
<212>  PRT
<213>  Gallus gallus

<400>  9

Met Gly Thr Asp Ser Glu Asn Pro Val Leu Arg Asn Val Leu Ile Ser 
1               5                   10                  15      


Phe Asn Leu Leu Leu Leu Gly Ala Val Leu Lys Pro Phe Glu Cys Arg 
            20                  25                  30          


Leu Glu Val Thr Thr Glu Pro Ala Glu Arg Pro Ala Val Asp Glu Glu 
        35                  40                  45              


Gly Gly Leu Ala Asn Cys Ser Pro Pro Val Lys Glu Gln Pro Met Val 
    50                  55                  60                  


Phe His His Ile Tyr Asn Ile Asn Val Pro Val Asp Ser Cys Cys Ser 
65                  70                  75                  80  


Ser Met Leu Arg Ser Ser Ala Glu Glu Val Ser Ser Glu Asp Asp Arg 
                85                  90                  95      


Leu Ala Glu Tyr Thr Glu Gln Thr Ser Asp Ser Glu Ser Gln Val Thr 
            100                 105                 110         


Phe Thr His Arg Ile Asn Leu Pro Lys Gln Ala Cys Lys Cys Ser Thr 
        115                 120                 125             


Ser Leu Pro Ser Leu Gln Glu Leu Leu Ser Arg Ile Glu Met Leu Glu 
    130                 135                 140                 


Arg Glu Val Ser Met Leu Arg Asp Gln Cys Asn Ser Asn Cys Cys Gln 
145                 150                 155                 160 


Glu Asn Ala Ala Thr Gly Arg Leu Asp Tyr Thr Leu Pro Cys Ser Gly 
                165                 170                 175     


His Gly Asn Phe Ser Leu Glu Ser Cys Arg Cys Ile Cys Ser Glu Gly 
            180                 185                 190         


Trp Ala Gly Ser Asn Cys Ser Glu Pro Arg Cys Pro Arg Gly Cys Ser 
        195                 200                 205             


Ser Arg Gly Val Cys Leu Glu Gly Gln Cys Val Cys Asp Asn Asp Tyr 
    210                 215                 220                 


Gly Gly Glu Asp Cys Ser Gln Leu Arg Cys Pro Ala Gly Cys Gly Ser 
225                 230                 235                 240 


Arg Gly Leu Cys Val Asp Gly Glu Cys Ile Cys Glu Glu Gly Phe Gly 
                245                 250                 255     


Gly Glu Asp Cys Ser Gln Pro Arg Cys Pro Arg Asp Cys Ser Gly Arg 
            260                 265                 270         


Gly His Cys Asp Asn Gly Thr Cys Val Cys Ala Glu Gly Tyr Ala Gly 
        275                 280                 285             


Glu Asp Cys Gly Trp Leu Arg Cys Pro Asn Ala Cys Ser Gly Arg Gly 
    290                 295                 300                 


Val Cys Gln Asp Gly Leu Cys Ile Cys Glu Asp Gly Tyr Gly Gly Gln 
305                 310                 315                 320 


Asp Cys Ser Ala Val Ala Pro Pro Glu Asn Leu Arg Val Thr Gly Ile 
                325                 330                 335     


Ser Asp Gly Ser Ile Glu Leu Ala Trp Asp Ser Leu Gly Ala Ala Thr 
            340                 345                 350         


Glu Tyr Val Val Ser Tyr Gln Pro Ala Gly Pro Gly Gly Ser Gln Leu 
        355                 360                 365             


Gln Gln Arg Val Pro Gly Asp Trp Ser Thr Ile Thr Ile Thr Glu Leu 
    370                 375                 380                 


Glu Pro Gly Val Ala Tyr Asn Val Ser Ile Tyr Ala Val Ile Ser Asp 
385                 390                 395                 400 


Val Leu Ser Ser Pro Val Thr Thr Lys Val Thr Thr Asn Leu Ala Thr 
                405                 410                 415     


Pro Gln Gly Leu Lys Phe Lys Thr Ile Thr Glu Thr Thr Val Glu Val 
            420                 425                 430         


Gln Trp Glu Pro Phe Ser Phe Pro Phe Asp Gly Trp Glu Ile Ser Phe 
        435                 440                 445             


Ile Pro Lys Asn Asn Glu Gly Gly Val Ile Ala Gln Leu Pro Ser Thr 
    450                 455                 460                 


Val Thr Thr Phe Asn Gln Thr Gly Leu Lys Pro Gly Glu Glu Tyr Thr 
465                 470                 475                 480 


Val Thr Val Val Ala Leu Lys Asp Gln Ala Arg Ser Pro Pro Ala Ser 
                485                 490                 495     


Asp Ser Ile Ser Thr Leu Ile Asp Gly Pro Thr Gln Ile Leu Val Arg 
            500                 505                 510         


Asp Val Ser Asp Thr Val Ala Phe Val Glu Trp Thr Pro Pro Arg Ala 
        515                 520                 525             


Arg Val Asp Ala Ile Leu Leu Lys Tyr Gly Leu Ala Asp Gly Glu Gly 
    530                 535                 540                 


Gly Arg Thr Thr Phe Arg Leu Gln Pro Pro Leu Ser Gln Tyr Ser Leu 
545                 550                 555                 560 


Gln Ala Leu Arg Pro Gly Ala Arg Tyr His Leu Ala Val Ser Ala Leu 
                565                 570                 575     


Arg Gly Ala Asn Glu Ser Gln Pro Ala Leu Ala Gln Phe Thr Thr Glu 
            580                 585                 590         


Ile Asp Ala Pro Lys Asn Leu Arg Val Gly Ser Arg Thr Pro Ala Ser 
        595                 600                 605             


Leu Glu Leu Thr Trp Asp Asn Ser Glu Ala Glu Ala His Ser Tyr Arg 
    610                 615                 620                 


Val Val Tyr Ser Thr Leu Ala Gly Glu His Tyr His Glu Val Leu Val 
625                 630                 635                 640 


Pro Arg Asp Thr Gly Pro Thr Thr Arg Ala Thr Leu Ala Asp Leu Val 
                645                 650                 655     


Pro Gly Thr Glu Tyr Gly Ile Gly Ile Ser Ala Val Met Asp Ser Gln 
            660                 665                 670         


Gln Ser Val Pro Ala Thr Met Asn Ala Arg Thr Glu Leu Asp Ser Pro 
        675                 680                 685             


Arg Asp Leu Leu Val Thr Ala Ser Thr Glu Thr Ser Ile Ser Leu Ser 
    690                 695                 700                 


Trp Thr Lys Ala Met Gly Pro Ile Asp His Tyr Arg Val Thr Phe Thr 
705                 710                 715                 720 


Pro Ala Ser Gly Met Ala Ser Glu Val Thr Val Ser Arg Asn Glu Ser 
                725                 730                 735     


Gln Leu Thr Leu Ser Glu Leu Glu Pro Gly Thr Glu Tyr Thr Ile Ser 
            740                 745                 750         


Ile Ile Ala Glu Arg Gly Arg Gln Gln Ser Leu Glu Ala Thr Val Asp 
        755                 760                 765             


Ala Phe Thr Gly Val Arg Pro Ile Thr Gln Leu His Phe Ser Gln Leu 
    770                 775                 780                 


Thr Ser Ser Ser Val Asn Ile Thr Trp Ser Asp Pro Ser Pro Pro Ala 
785                 790                 795                 800 


Asp Arg Leu Val Leu Thr Tyr Ser Pro Arg Asp Glu Glu Ala Pro Gln 
                805                 810                 815     


Gln Leu Ala Leu Asp Gly Thr Arg Arg His Ala Ser Leu Thr Gly Leu 
            820                 825                 830         


Arg Pro Ser Thr Glu Tyr Leu Val Ser Leu Val Ala Val His Gly Ala 
        835                 840                 845             


Val Ser Ser Glu Pro Val Thr Gly Ser Ile Thr Thr Gly Met Asp Ala 
    850                 855                 860                 


Pro Lys Asp Leu Arg Val Gly Asn Ile Thr Gln Asp Ser Met Val Ile 
865                 870                 875                 880 


Tyr Trp Ser Pro Pro Val Ala Pro Phe Asp His Tyr Arg Ile Ser Tyr 
                885                 890                 895     


Arg Ala Ala Glu Gly Arg Thr Asp Ser Thr Ala Ile Gly Asn Asp Ala 
            900                 905                 910         


Thr Glu Tyr Ile Met Arg Leu Leu Gln Pro Ala Thr Lys Tyr Glu Ile 
        915                 920                 925             


Gly Val Lys Ser Val Arg Gly Arg Glu Glu Ser Glu Val Ala Ser Ile 
    930                 935                 940                 


Thr Thr Tyr Thr Ala Met Asp Ala Pro Leu Gly Val Thr Ala Thr Asn 
945                 950                 955                 960 


Ile Thr Pro Thr Glu Ala Leu Leu Gln Trp Asn Pro Pro Leu Met Asp 
                965                 970                 975     


Val Glu Ser Tyr Val Leu Val Leu Thr Arg His Thr Gly Glu Thr Ile 
            980                 985                 990         


Leu Val Asp Gly Ile Asn Gln Glu  Tyr Gln Leu Thr Asn  Leu Gln Pro 
        995                 1000                 1005             


Ser Thr  Thr Tyr Thr Val Ala  Met Tyr Ala Thr Asn  Gly Pro Leu 
    1010                 1015                 1020             


Thr Ser  Gln Thr Ile Ser Thr  Asn Phe Thr Thr Leu  Leu Asp Pro 
    1025                 1030                 1035             


Pro Thr  Asn Leu Thr Ala Ser  Glu Val Thr Arg Arg  Ser Ala Leu 
    1040                 1045                 1050             


Leu Ser  Trp Val Pro Pro Val  Gly Asp Ile Glu Asn  Tyr Ile Leu 
    1055                 1060                 1065             


Thr Tyr  Arg Ser Thr Asp Gly  Ser Arg Lys Glu Leu  Ile Val Asp 
    1070                 1075                 1080             


Ala Glu  Asp Thr Trp Ile Arg  Leu Glu Gly Leu Ser  Glu Thr Thr 
    1085                 1090                 1095             


Gln Tyr  Thr Val Arg Leu Gln  Ala Ala Gln Asn Ala  Met Arg Ser 
    1100                 1105                 1110             


Gly Phe  Ile Ser Thr Thr Phe  Thr Thr Gly Gly Arg  Val Phe Ala 
    1115                 1120                 1125             


Asn Pro  Gln Asp Cys Ala Gln  His Leu Met Asn Gly  Asp Thr Leu 
    1130                 1135                 1140             


Ser Gly  Val Tyr Thr Ile Ser  Ile Asn Gly Asp Leu  Ser Gln Arg 
    1145                 1150                 1155             


Val Gln  Val Phe Cys Asp Met  Ser Thr Asp Gly Gly  Gly Trp Ile 
    1160                 1165                 1170             


Val Phe  Gln Arg Arg Gln Asn  Gly Leu Thr Asp Phe  Phe Arg Lys 
    1175                 1180                 1185             


Trp Ala  Asp Tyr Arg Val Gly  Phe Gly Asn Leu Glu  Asp Glu Phe 
    1190                 1195                 1200             


Trp Leu  Gly Leu Asp Asn Ile  His Lys Ile Thr Ser  Gln Gly Arg 
    1205                 1210                 1215             


Tyr Glu  Leu Arg Ile Asp Met  Arg Asp Gly Gln Glu  Ala Ala Tyr 
    1220                 1225                 1230             


Ala Tyr  Tyr Asp Lys Phe Ser  Val Gly Asp Ser Arg  Ser Leu Tyr 
    1235                 1240                 1245             


Lys Leu  Arg Ile Gly Asp Tyr  Asn Gly Thr Ser Gly  Asp Ser Leu 
    1250                 1255                 1260             


Thr Tyr  His Gln Gly Arg Pro  Phe Ser Thr Lys Asp  Arg Asp Asn 
    1265                 1270                 1275             


Asp Val  Ala Val Thr Asn Cys  Ala Met Ser Tyr Lys  Gly Ala Trp 
    1280                 1285                 1290             


Trp Tyr  Lys Asn Cys His Arg  Thr Asn Leu Asn Gly  Lys Tyr Gly 
    1295                 1300                 1305             


Glu Ser  Arg His Ser Gln Gly  Ile Asn Trp Tyr His  Trp Lys Gly 
    1310                 1315                 1320             


His Glu  Phe Ser Ile Pro Phe  Val Glu Met Lys Met  Arg Pro Tyr 
    1325                 1330                 1335             


Asn His  Arg Asn Ile Ser Gly  Arg Lys Arg Arg Ser  Leu Gln Leu 
    1340                 1345                 1350             


<210>  10
<211>  1350
<212>  PRT
<213>  Danio rerio

<400>  10

Met Trp Gly Cys Ala Met Ala Ile Gln Gly Ser Val Val Ser Leu Ala 
1               5                   10                  15      


Leu Leu Phe Phe Gly Ile Gln Ala Val Pro Ser Pro Thr Ser Lys Leu 
            20                  25                  30          


Val Arg Thr Thr Arg Val Arg Arg Gln Val Pro Glu Gly Gly Asp Pro 
        35                  40                  45              


Ala Asp Asn Gln Met Gln Pro Met Val Phe Asn His Val Tyr Asn Ile 
    50                  55                  60                  


Asn Val Pro Val Glu Ser Leu Cys Ser Val Asp Leu Asp Ala Val Thr 
65                  70                  75                  80  


Gly Pro Glu Thr Asn Lys Thr Ala Ser Gly Ser Asp Lys Met Pro Thr 
                85                  90                  95      


Glu Tyr Thr Glu Glu Thr Val Asp Ser Asp Ser Gln Val Thr Phe Thr 
            100                 105                 110         


His Arg Ile Asn Ile Pro Lys Gln Ala Cys Ala Cys Pro Ser Ala Thr 
        115                 120                 125             


Thr Ile Glu Gln Leu Ala Ser Arg Ile Glu Met Leu Glu Arg Glu Val 
    130                 135                 140                 


Ser Leu Leu Arg Thr Gln Cys Ser Ser Ser Cys Cys Gly Glu Ser Ser 
145                 150                 155                 160 


Val Met Gly Arg Leu Asp Phe Val Pro Gln Cys Gly His Gly Thr Phe 
                165                 170                 175     


Ser Met Glu Val Cys Gly Cys Val Cys Glu Glu Gly Trp Ile Gly Lys 
            180                 185                 190         


Asn Cys Thr Glu Pro Arg Cys Pro Asp Asp Cys Ser Gly Gln Gly Ile 
        195                 200                 205             


Cys Ile Glu Gly Asp Cys Val Cys Asp Arg Asn Phe Gly Gly Glu Asn 
    210                 215                 220                 


Cys Ser Glu Pro Arg Cys Pro Ser Asp Cys Ser Asp Arg Gly Leu Cys 
225                 230                 235                 240 


Ile Asp Gly Glu Cys Val Cys Glu Glu Ala Phe Ala Gly Glu Asp Cys 
                245                 250                 255     


Ser Leu Gly Arg Cys Leu Asn Asp Cys Ser Asp Gln Gly Ala Cys Val 
            260                 265                 270         


Asn Gly Ser Cys Gln Cys Arg Ser Gly Phe Leu Gly Glu Asp Cys Ser 
        275                 280                 285             


Leu Ile Phe Cys Ala Asn Asn Cys Ser Gln Arg Gly Val Cys Lys Glu 
    290                 295                 300                 


Gly Phe Cys Val Cys Gln Glu Gly Tyr Thr Gly Asp Asp Cys Thr Ser 
305                 310                 315                 320 


Val Leu Pro Pro Met Asn Leu Arg Val Arg Gly Val Ser Glu Asn Thr 
                325                 330                 335     


Ile Asp Leu Gln Trp Glu Gly Pro Ala Ile Leu Thr Asp Tyr Leu Ile 
            340                 345                 350         


Thr Tyr Ala Pro Thr Thr Pro Gly Gly Val Gln Leu Glu Met Arg Val 
        355                 360                 365             


Pro Gly Asn Val Thr Asn Ile Thr Ile Lys Gly Leu Asn Pro Gly Leu 
    370                 375                 380                 


Glu Tyr Asn Val Asn Val Tyr Ala Val Ile Asp Asn Ile Ile Ser Ser 
385                 390                 395                 400 


Pro Met Asn Thr Leu Val Ser Thr Tyr Leu Ser Asn Pro Asp Gly Leu 
                405                 410                 415     


Leu Phe Lys Ser Ile Met Glu Thr Ser Val Glu Val Gln Trp Gln Pro 
            420                 425                 430         


Leu Asp Tyr Leu Phe Asp Gly Trp Glu Ile Ser Phe Ile Pro Lys Asp 
        435                 440                 445             


Asn Asp Gly Gly Met Thr Ala Gln Leu Pro Ser Thr Ile Thr Ser Phe 
    450                 455                 460                 


His Gln Thr Gly Leu Lys Pro Gly Glu Glu Tyr Thr Val Asn Leu Val 
465                 470                 475                 480 


Ala Leu Lys Asp Gln Gly Arg Ser Leu Pro Val Thr Ala Thr Val Thr 
                485                 490                 495     


Thr Leu Ile Asp Gly Pro Ile Gln Leu Ile Val Arg Asp Ile Ser Asp 
            500                 505                 510         


Thr Val Ala Phe Val Glu Trp Ser Pro Pro Lys Ala Lys Val Asp Gln 
        515                 520                 525             


Ile Ile Leu Arg Tyr Gly Leu Val Gly Val Glu Gly Pro Lys Thr Thr 
    530                 535                 540                 


Phe Arg Leu Gln Pro Thr Leu Ser Gln Tyr Ser Leu Gln Val Leu Arg 
545                 550                 555                 560 


Pro Gly Ser Thr Tyr Glu Val Ser Val Ser Gly Val Arg Asn Gly Thr 
                565                 570                 575     


Glu Ser Gly Val Ile Ser Thr Glu Phe Thr Thr Glu Ile Asp Ala Pro 
            580                 585                 590         


Lys Asn Leu Arg Val Leu Ser Lys Thr Ser Ile Ser Leu Glu Leu Glu 
        595                 600                 605             


Trp Asp Asn Ser Glu Ala Asp Val Glu Gly Tyr Ser Val Val Tyr Ser 
    610                 615                 620                 


Thr Leu Ala Gly Asp Gln Tyr Asp Lys Val Ile Val Pro Arg Asn Asp 
625                 630                 635                 640 


Gly Pro Ser Thr Lys Thr Thr Leu Asn Glu Leu Met Pro Gly Thr Glu 
                645                 650                 655     


Tyr Gly Ile Gly Ile Ser Ala Val Leu Gly Ala Asn Gln Ser Thr Pro 
            660                 665                 670         


Ala Thr Met Asn Ala Arg Thr Gly Leu Asp Val Pro Leu Asp Leu Thr 
        675                 680                 685             


Val Thr Ala Ser Thr Asp Asn Thr Ile Thr Leu Leu Trp Gly Thr Val 
    690                 695                 700                 


Gln Gly Pro Ile Asp His Tyr Arg Val Thr Tyr Thr Ser Ser Ser Gly 
705                 710                 715                 720 


Val Thr Thr Glu Leu Thr Val Pro Lys Asp Val Thr Thr Thr Thr Leu 
                725                 730                 735     


Thr Ser Leu Glu Pro Gly Thr Lys Tyr Thr Ile Thr Val Ala Ala Gln 
            740                 745                 750         


Arg Gly Arg Gln Gln Ser Thr Ala Ala Thr Ile Asp Ala Phe Thr Gly 
        755                 760                 765             


Phe Arg Pro Ile Thr Gln Leu Phe Phe Ser Glu Val Ser Ser Asp Ser 
    770                 775                 780                 


Leu Thr Val Ala Trp Ser Ser Pro Ala Pro Pro Ala Asp Ala Phe Ile 
785                 790                 795                 800 


Leu Asn Tyr Ser Ala Gln Asp Ser Ser Glu Asp Ser Glu Ile Ala Leu 
                805                 810                 815     


Asp Gly Ser Lys Thr Arg Ile Thr Leu Thr Gly Leu Met Pro Ser Arg 
            820                 825                 830         


Arg Tyr Thr Val Thr Leu Val Thr Met His Gly Asn Val Thr Ser Lys 
        835                 840                 845             


Pro Val Val Gly Ser Val Asn Thr Gly Met Asp Pro Pro Arg Asp Ile 
    850                 855                 860                 


Thr Val Leu Tyr Val Thr Glu Glu Ser Val Thr Ile Thr Trp Ile Gln 
865                 870                 875                 880 


Pro Leu Ala Leu Phe Asp Tyr Tyr Arg Met Ser Tyr Gln Ser Ser Lys 
                885                 890                 895     


Gly Arg Met Asp Ser Val Val Ile Asp Asn Asp Ile Asn Asn Tyr Thr 
            900                 905                 910         


Leu Thr Ser Leu His Pro Ala Thr Glu Tyr Glu Ile Lys Leu Asn Ala 
        915                 920                 925             


Val Arg Gly Ser Gln Glu Ser Lys Val Ile Thr Thr Thr Val Phe Thr 
    930                 935                 940                 


Ala Met Asp Met Pro Ala Glu Leu Thr Ala Leu Asn Val Thr Pro Gln 
945                 950                 955                 960 


Gly Ala Leu Leu Arg Trp Asn Pro Pro Ala Ser Ser Val Asp Asn Tyr 
                965                 970                 975     


Val Leu Thr Val Thr Arg Asn Gln Val Thr Ala Asp Thr Phe Leu Val 
            980                 985                 990         


Glu Gly Asn Lys Gln Glu Tyr Gln  Leu Ser Gln Leu Ile  Pro Ser Thr 
        995                 1000                 1005             


Thr Tyr  Ser Val Ala Leu Tyr  Ala Thr Lys Gly Pro  Leu Thr Ser 
    1010                 1015                 1020             


Gly Thr  Val Ile Ser Asn Phe  Val Thr Pro Met Asp  Ala Pro Gln 
    1025                 1030                 1035             


Asn Leu  Thr Ala Ser Glu Ile  Asn His Arg Ser Ala  Leu Ile Ser 
    1040                 1045                 1050             


Trp Gln  Pro Pro Ile Ala Asp  Ile Asp Asn Tyr Met  Leu Thr Tyr 
    1055                 1060                 1065             


Lys Ala  Ala Asp Gly Ser Arg  Lys Glu Leu Ile Leu  Asp Ala Glu 
    1070                 1075                 1080             


Asp Thr  Trp Ile Arg Leu Glu  Gly Leu Ala Glu Thr  Thr Glu Tyr 
    1085                 1090                 1095             


Thr Val  Arg Leu Gln Ala Ala  Arg Gly Leu Glu Thr  Ser Ala Ile 
    1100                 1105                 1110             


Val Ser  Thr Ser Phe Thr Thr  Gly Asn Arg Leu Phe  Pro Thr Pro 
    1115                 1120                 1125             


Gln Asn  Cys Ala Gln His Leu  Leu Asn Gly Glu Thr  Leu Gly Gly 
    1130                 1135                 1140             


Ile Tyr  Thr Ile Tyr Val Asn  Arg Asp Leu Ser Gln  Gly Val Gln 
    1145                 1150                 1155             


Val Tyr  Cys Asp Met Thr Thr  Asp Gly Gly Gly Trp  Ile Val Phe 
    1160                 1165                 1170             


Gln Arg  Arg Gln Asn Gly Leu  Thr Asp Phe Ser Arg  Lys Trp Thr 
    1175                 1180                 1185             


Asp Tyr  Lys Ile Gly Phe Gly  Asn Leu Glu Asp Glu  Phe Trp Leu 
    1190                 1195                 1200             


Gly Leu  Asp Asn Ile His Lys  Ile Ala Ala Gln Gly  Arg Tyr Glu 
    1205                 1210                 1215             


Leu Arg  Ile Asp Met Lys Asp  Gly Gln Glu Ser Val  Tyr Ala Asn 
    1220                 1225                 1230             


Tyr Asp  Arg Phe Ser Ile Gly  Asp Ser Lys Ser Leu  Tyr Lys Leu 
    1235                 1240                 1245             


Arg Ile  Gly Glu Tyr Asn Gly  Thr Ala Gly Asp Ser  Leu Ser Tyr 
    1250                 1255                 1260             


His Gln  Ser Arg Pro Phe Ser  Thr Lys Asp Lys Asp  Asn Asp Ile 
    1265                 1270                 1275             


Ala Val  Thr Asn Cys Ala Leu  Ser Tyr Lys Gly Ala  Trp Trp Tyr 
    1280                 1285                 1290             


Lys Asn  Cys His Arg Ala Asn  Leu Asn Gly Lys Tyr  Gly Glu Ser 
    1295                 1300                 1305             


Arg His  Ser Gln Gly Ile Asn  Trp Tyr His Trp Lys  Gly His Glu 
    1310                 1315                 1320             


Phe Ser  Ile Pro Phe Val Glu  Met Lys Met Arg Pro  Phe Asn Tyr 
    1325                 1330                 1335             


Arg Ser  Ile Ser Gly Lys Arg  Arg Arg Ser Thr His  
    1340                 1345                 1350 





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