                         SEQUENCE LISTING

<110>  Biotest AG
 
<120>  Pharmaceutical Composition for Treating Disease

<130>  322248.WO/JND/CJS

<160>  16    

<170>  PatentIn version 3.3

<210>  1
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V domain of H chain of humanized antibody hB-F5H37L

<400>  1

Glu Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Cys 
            20                  25                  30          


Arg Met Tyr Trp Leu Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Val Lys Ser Glu Asn Tyr Gly Ala Asn Tyr Ala Glu 
    50                  55                  60                  


Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Ala Ser Tyr Tyr Arg Tyr Asp Val Gly Ala Trp Phe Ala 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  2
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V domain of K chain of humanized antibody hB-F5L4M

<400>  2

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Ile Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  3
<211>  550
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Part of plasmid encoding V domain of H chain of humanized 
       antibody hB-F5

<400>  3
gaggagctcc agacaatgtc tgtctccttc ctcatcttcc tgcccgtgct gggcctccca     60

tggggtcagt gtcagggaga tgccgtattc acagcagcat tcacagactg aggggtgttt    120

cactttgctg tttccttttg tctccaggtg tcctgtcaga ggaacagctt gtggagtctg    180

ggggaggctt ggtgaaaccc ggaggttctc tgaggctctc ctgtgcagcc tcgggtttca    240

gtttcagtga ctgccggatg tactgggttc gccaggctcc agggaagggg ctggagtgga    300

ttggtgtgat ttcagtcaaa tctgagaatt atggagcaaa ttatgcagag tctgtgaggg    360

gcagattcac tatttcaaga gatgattcaa aaaacacggt ctatctgcag atgaacagct    420

tgaagaccga agacactgcc gtttattatt gtagtgcctc ctattatagg tacgacgtgg    480

gggcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctcttca ggtaagaatg    540

gccaagcttg                                                           550


<210>  4
<211>  498
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Part of plasmid encoding V domain of K chain of humanized 
       antibody hB-F5

<400>  4
ggaggatcca attatctgct gacttataat actactagaa agcaaattta aatgacatat     60

ttcaattata tctgagacag cgtgtataag tttatgtata atcattgtcc attcctgact    120

acaggtgcct acggggacat cgtgatgacc cagtctccag actccctggc tgtgtctctg    180

ggcgagaggg ccaccatcaa ctgcagggcc agcaaaagtg tcagtacatc tggctacagt    240

tatatatatt ggtaccagca gaaaccagga cagcctccta agctgctcat ttaccttgca    300

tccatcctag aatctggggt ccctgaccga ttcagtggca gcgggtctgg gacagatttc    360

actctcacca tcagcagcct gcaggctgaa gatgtggcag tttattactg tcagcacagt    420

agggaacttc cgtggacgtt cggccaaggg accaaggtgg aaatcaaacg tgagtagaat    480

ttaaatttta agcttctt                                                  498



<210>  5
<211>  124
<212>  PRT
<213>  Mus musculus

<400>  5

Gln Glu Tyr Leu Val Glu Thr Gly Gly Gly Leu Val Arg Pro Gly Asn 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Thr Ser Gly Phe Ser Phe Ser Asp Cys 
            20                  25                  30          


Arg Met Tyr Trp Leu Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Val Lys Ser Glu Asn Tyr Gly Ala Asn Tyr Ala Glu 
    50                  55                  60                  


Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Ser Arg Leu Arg Glu Glu Asp Thr Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Ser Ala Ser Tyr Tyr Arg Tyr Asp Val Gly Ala Trp Phe Ala 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120                 


<210>  6
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  6

Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Val Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Ile Tyr Trp Tyr Gln Gln Ile Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Ile Leu Glu Ser Gly Val Pro Gly 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  7
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  7

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys 
            20              


<210>  8
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  8

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  9
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  9

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  10
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  10

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  11
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  12
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  12

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 
1               5                   10                  


<210>  13
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  13

Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Thr Thr 
            20                  25                  30          


<210>  14
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  14

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  15
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V domain of the H chain of humanized antibody hB-F5H37V

<400>  15

Glu Glu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asp Cys 
            20                  25                  30          


Arg Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Ser Val Lys Ser Glu Asn Tyr Gly Ala Asn Tyr Ala Glu 
    50                  55                  60                  


Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Ala Ser Tyr Tyr Arg Tyr Asp Val Gly Ala Trp Phe Ala 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  16
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V domain of K chain of humanized antibody hB-F5L4L

<400>  16

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Ile Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


