                         SEQUENCE LISTING

<110>  The Regents of the University of Colorado, a body corporate
       Thurman, Joshua M.
       Holers, V. Michael
 
<120>  Modulating the Alternative Complement Pathway

<130>  019269-005810PC

<150>  61/099173
<151>  2008-09-22

<160>  30    

<170>  PatentIn version 3.3

<210>  1
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp 
1               5                   10                  15      


His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Ala Tyr Thr Asn 
            20                  25                  30          


Phe Asp Ala Glu Arg Asp Ala Leu Asn Ile Glu Thr Ala Ile Lys Thr 
        35                  40                  45              


Lys Gly Val Asp Glu Val Thr Ile Val Asn Ile Leu Thr Asn Arg Ser 
    50                  55                  60                  


Asn Ala Gln Arg Gln Asp Ile Ala Phe Ala Tyr Gln Arg Arg Thr Lys 
65                  70                  75                  80  


Lys Glu Leu Ala Ser Ala Leu Lys Ser Ala Leu Ser Gly His Leu Glu 
                85                  90                  95      


Thr Val Ile Leu Gly Leu Leu Lys Thr Pro Ala Gln Tyr Asp Ala Ser 
            100                 105                 110         


Glu Leu Lys Ala Ser Met Lys Gly Leu Gly Thr Asp Glu Asp Ser Leu 
        115                 120                 125             


Ile Glu Ile Ile Cys Ser Arg Thr Asn Gln Glu Leu Gln Glu Ile Asn 
    130                 135                 140                 


Arg Val Tyr Lys Glu Met Tyr Lys Thr Asp Leu Glu Lys Asp Ile Ile 
145                 150                 155                 160 


Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Met Val Ala Leu Ala Lys 
                165                 170                 175     


Gly Arg Arg Ala Glu Asp Gly Ser Val Ile Asp Tyr Glu Leu Ile Asp 
            180                 185                 190         


Gln Asp Ala Arg Asp Leu Tyr Asp Ala Gly Val Lys Arg Lys Gly Thr 
        195                 200                 205             


Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser Val Pro His 
    210                 215                 220                 


Leu Gln Lys Val Phe Asp Arg Tyr Lys Ser Tyr Ser Pro Tyr Asp Met 
225                 230                 235                 240 


Leu Glu Ser Ile Arg Lys Glu Val Lys Gly Asp Leu Glu Asn Ala Phe 
                245                 250                 255     


Leu Asn Leu Val Gln Cys Ile Gln Asn Lys Pro Leu Tyr Phe Ala Asp 
            260                 265                 270         


Arg Leu Tyr Asp Ser Met Lys Gly Lys Gly Thr Arg Asp Lys Val Leu 
        275                 280                 285             


Ile Arg Ile Met Val Ser Arg Ser Glu Val Asp Met Leu Lys Ile Arg 
    290                 295                 300                 


Ser Glu Phe Lys Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr Tyr Ile Gln 
305                 310                 315                 320 


Gln Asp Thr Lys Gly Asp Tyr Gln Lys Ala Leu Leu Tyr Leu Cys Gly 
                325                 330                 335     


Gly Asp Asp 
            


<210>  2
<211>  1020
<212>  DNA
<213>  Homo sapiens

<400>  2
atgtctactg ttcacgaaat cctgtgcaag ctcagcttgg agggtgatca ctctacaccc     60

ccaagtgcat atgggtctgt caaagcctat actaactttg atgctgagcg ggatgctttg    120

aacattgaaa cagccatcaa gaccaaaggt gtggatgagg tcaccattgt caacattttg    180

accaaccgca gcaatgcaca gagacaggat attgccttcg cctaccagag aaggaccaaa    240

aaggaacttg catcagcact gaagtcagcc ttatctggcc acctggagac ggtgattttg    300

ggcctattga agacacctgc tcagtatgac gcttctgagc taaaagcttc catgaagggg    360

ctgggaaccg acgaggactc tctcattgag atcatctgct ccagaaccaa ccaggagctg    420

caggaaatta acagagtcta caaggaaatg tacaagactg atctggagaa ggacattatt    480

tcggacacat ctggtgactt ccgcaagctg atggttgccc tggcaaaggg tagaagagca    540

gaggatggct ctgtcattga ttatgaactg attgaccaag atgctcggga tctctatgac    600

gctggagtga agaggaaagg aactgatgtt cccaagtgga tcagcatcat gaccgagcgg    660

agcgtgcccc acctccagaa agtatttgat aggtacaaga gttacagccc ttatgacatg    720

ttggaaagca tcaggaaaga ggttaaagga gacctggaaa atgctttcct gaacctggtt    780

cagtgcattc agaacaagcc cctgtatttt gctgatcggc tgtatgactc catgaagggc    840

aaggggacgc gagataaggt cctgatcaga atcatggtct cccgcagtga agtggacatg    900

ttgaaaatta ggtctgaatt caagagaaag tacggcaagt ccctgtacta ttatatccag    960

caagacacta agggcgacta ccagaaagcg ctgctgtacc tgtgtggtgg agatgactga   1020


<210>  3
<211>  1231
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 


Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             


Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 


Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 


Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     


Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         


Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             


Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 


Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 


Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     


His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         


Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             


Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 


Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 


Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     


Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         


Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             


Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
    690                 695                 700                 


Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
705                 710                 715                 720 


Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
                725                 730                 735     


Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
            740                 745                 750         


Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys 
        755                 760                 765             


Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys 
    770                 775                 780                 


Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu 
785                 790                 795                 800 


Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln 
                805                 810                 815     


Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly 
            820                 825                 830         


Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly 
        835                 840                 845             


Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys 
    850                 855                 860                 


Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr 
865                 870                 875                 880 


Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys 
                885                 890                 895     


Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu 
            900                 905                 910         


Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly 
        915                 920                 925             


Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His 
    930                 935                 940                 


Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe 
945                 950                 955                 960 


Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu 
                965                 970                 975     


Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu 
            980                 985                 990         


Pro Ser Phe Glu Asn Ala Ile Pro  Met Gly Glu Lys Lys  Asp Val Tyr 
        995                 1000                 1005             


Lys Ala  Gly Glu Gln Val Thr  Tyr Thr Cys Ala Thr  Tyr Tyr Lys 
    1010                 1015                 1020             


Met Asp  Gly Ala Ser Asn Val  Thr Cys Ile Asn Ser  Arg Trp Thr 
    1025                 1030                 1035             


Gly Arg  Pro Thr Cys Arg Asp  Thr Ser Cys Val Asn  Pro Pro Thr 
    1040                 1045                 1050             


Val Gln  Asn Ala Tyr Ile Val  Ser Arg Gln Met Ser  Lys Tyr Pro 
    1055                 1060                 1065             


Ser Gly  Glu Arg Val Arg Tyr  Gln Cys Arg Ser Pro  Tyr Glu Met 
    1070                 1075                 1080             


Phe Gly  Asp Glu Glu Val Met  Cys Leu Asn Gly Asn  Trp Thr Glu 
    1085                 1090                 1095             


Pro Pro  Gln Cys Lys Asp Ser  Thr Gly Lys Cys Gly  Pro Pro Pro 
    1100                 1105                 1110             


Pro Ile  Asp Asn Gly Asp Ile  Thr Ser Phe Pro Leu  Ser Val Tyr 
    1115                 1120                 1125             


Ala Pro  Ala Ser Ser Val Glu  Tyr Gln Cys Gln Asn  Leu Tyr Gln 
    1130                 1135                 1140             


Leu Glu  Gly Asn Lys Arg Ile  Thr Cys Arg Asn Gly  Gln Trp Ser 
    1145                 1150                 1155             


Glu Pro  Pro Lys Cys Leu His  Pro Cys Val Ile Ser  Arg Glu Ile 
    1160                 1165                 1170             


Met Glu  Asn Tyr Asn Ile Ala  Leu Arg Trp Thr Ala  Lys Gln Lys 
    1175                 1180                 1185             


Leu Tyr  Ser Arg Thr Gly Glu  Ser Val Glu Phe Val  Cys Lys Arg 
    1190                 1195                 1200             


Gly Tyr  Arg Leu Ser Ser Arg  Ser His Thr Leu Arg  Thr Thr Cys 
    1205                 1210                 1215             


Trp Asp  Gly Lys Leu Glu Tyr  Pro Thr Cys Ala Lys  Arg 
    1220                 1225                 1230     


<210>  4
<211>  3696
<212>  DNA
<213>  Homo sapiens

<400>  4
atgagacttc tagcaaagat tatttgcctt atgttatggg ctatttgtgt agcagaagat     60

tgcaatgaac ttcctccaag aagaaataca gaaattctga caggttcctg gtctgaccaa    120

acatatccag aaggcaccca ggctatctat aaatgccgcc ctggatatag atctcttgga    180

aatgtaataa tggtatgcag gaagggagaa tgggttgctc ttaatccatt aaggaaatgt    240

cagaaaaggc cctgtggaca tcctggagat actccttttg gtacttttac ccttacagga    300

ggaaatgtgt ttgaatatgg tgtaaaagct gtgtatacat gtaatgaggg gtatcaattg    360

ctaggtgaga ttaattaccg tgaatgtgac acagatggat ggaccaatga tattcctata    420

tgtgaagttg tgaagtgttt accagtgaca gcaccagaga atggaaaaat tgtcagtagt    480

gcaatggaac cagatcggga ataccatttt ggacaagcag tacggtttgt atgtaactca    540

ggctacaaga ttgaaggaga tgaagaaatg cattgttcag acgatggttt ttggagtaaa    600

gagaaaccaa agtgtgtgga aatttcatgc aaatccccag atgttataaa tggatctcct    660

atatctcaga agattattta taaggagaat gaacgatttc aatataaatg taacatgggt    720

tatgaataca gtgaaagagg agatgctgta tgcactgaat ctggatggcg tccgttgcct    780

tcatgtgaag aaaaatcatg tgataatcct tatattccaa atggtgacta ctcaccttta    840

aggattaaac acagaactgg agatgaaatc acgtaccagt gtagaaatgg tttttatcct    900

gcaacccggg gaaatacagc caaatgcaca agtactggct ggatacctgc tccgagatgt    960

accttgaaac cttgtgatta tccagacatt aaacatggag gtctatatca tgagaatatg   1020

cgtagaccat actttccagt agctgtagga aaatattact cctattactg tgatgaacat   1080

tttgagactc cgtcaggaag ttactgggat cacattcatt gcacacaaga tggatggtcg   1140

ccagcagtac catgcctcag aaaatgttat tttccttatt tggaaaatgg atataatcaa   1200

aatcatggaa gaaagtttgt acagggtaaa tctatagacg ttgcctgcca tcctggctac   1260

gctcttccaa aagcgcagac cacagttaca tgtatggaga atggctggtc tcctactccc   1320

agatgcatcc gtgtcaaaac atgttccaaa tcaagtatag atattgagaa tgggtttatt   1380

tctgaatctc agtatacata tgccttaaaa gaaaaagcga aatatcaatg caaactagga   1440

tatgtaacag cagatggtga aacatcagga tcaattagat gtgggaaaga tggatggtca   1500

gctcaaccca cgtgcattaa atcttgtgat atcccagtat ttatgaatgc cagaactaaa   1560

aatgacttca catggtttaa gctgaatgac acattggact atgaatgcca tgatggttat   1620

gaaagcaata ctggaagcac cactggttcc atagtgtgtg gttacaatgg ttggtctgat   1680

ttacccatat gttatgaaag agaatgcgaa cttcctaaaa tagatgtaca cttagttcct   1740

gatcgcaaga aagaccagta taaagttgga gaggtgttga aattctcctg caaaccagga   1800

tttacaatag ttggacctaa ttccgttcag tgctaccact ttggattgtc tcctgacctc   1860

ccaatatgta aagagcaagt acaatcatgt ggtccacctc ctgaactcct caatgggaat   1920

gttaaggaaa aaacgaaaga agaatatgga cacagtgaag tggtggaata ttattgcaat   1980

cctagatttc taatgaaggg acctaataaa attcaatgtg ttgatggaga gtggacaact   2040

ttaccagtgt gtattgtgga ggagagtacc tgtggagata tacctgaact tgaacatggc   2100

tgggcccagc tttcttcccc tccttattac tatggagatt cagtggaatt caattgctca   2160

gaatcattta caatgattgg acacagatca attacgtgta ttcatggagt atggacccaa   2220

cttccccagt gtgtggcaat agataaactt aagaagtgca aatcatcaaa tttaattata   2280

cttgaggaac atttaaaaaa caagaaggaa ttcgatcata attctaacat aaggtacaga   2340

tgtagaggaa aagaaggatg gatacacaca gtctgcataa atggaagatg ggatccagaa   2400

gtgaactgct caatggcaca aatacaatta tgcccacctc cacctcagat tcccaattct   2460

cacaatatga caaccacact gaattatcgg gatggagaaa aagtatctgt tctttgccaa   2520

gaaaattatc taattcagga aggagaagaa attacatgca aagatggaag atggcagtca   2580

ataccactct gtgttgaaaa aattccatgt tcacaaccac ctcagataga acacggaacc   2640

attaattcat ccaggtcttc acaagaaagt tatgcacatg ggactaaatt gagttatact   2700

tgtgagggtg gtttcaggat atctgaagaa aatgaaacaa catgctacat gggaaaatgg   2760

agttctccac ctcagtgtga aggccttcct tgtaaatctc cacctgagat ttctcatggt   2820

gttgtagctc acatgtcaga cagttatcag tatggagaag aagttacgta caaatgtttt   2880

gaaggttttg gaattgatgg gcctgcaatt gcaaaatgct taggagaaaa atggtctcac   2940

cctccatcat gcataaaaac agattgtctc agtttaccta gctttgaaaa tgccataccc   3000

atgggagaga agaaggatgt gtataaggcg ggtgagcaag tgacttacac ttgtgcaaca   3060

tattacaaaa tggatggagc cagtaatgta acatgcatta atagcagatg gacaggaagg   3120

ccaacatgca gagacacctc ctgtgtgaat ccgcccacag tacaaaatgc ttatatagtg   3180

tcgagacaga tgagtaaata tccatctggt gagagagtac gttatcaatg taggagccct   3240

tatgaaatgt ttggggatga agaagtgatg tgtttaaatg gaaactggac ggaaccacct   3300

caatgcaaag attctacagg aaaatgtggg ccccctccac ctattgacaa tggggacatt   3360

acttcattcc cgttgtcagt atatgctcca gcttcatcag ttgagtacca atgccagaac   3420

ttgtatcaac ttgagggtaa caagcgaata acatgtagaa atggacaatg gtcagaacca   3480

ccaaaatgct tacatccgtg tgtaatatcc cgagaaatta tggaaaatta taacatagca   3540

ttaaggtgga cagccaaaca gaagctttat tcgagaacag gtgaatcagt tgaatttgtg   3600

tgtaaacggg gatatcgtct ttcatcacgt tctcacacat tgcgaacaac atgttgggat   3660

gggaaactgg agtatccaac ttgtgcaaaa agatag                             3696


<210>  5
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  5

Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      


Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          


Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys 
        35                  40                  45              


Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  


Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  


Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      


Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         


Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             


Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 


Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 


Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     


Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         


Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             


Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 


Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 


Leu Pro Ser Cys Glu Glu 
                245     


<210>  6
<211>  489
<212>  PRT
<213>  Homo sapiens

<400>  6

Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      


Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          


Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys 
        35                  40                  45              


Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  


Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  


Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      


Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         


Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             


Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 


Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 


Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     


Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         


Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             


Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 


Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 


Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn 
                245                 250                 255     


Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu Ile 
            260                 265                 270         


Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr 
        275                 280                 285             


Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr Leu 
    290                 295                 300                 


Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr His Glu 
305                 310                 315                 320 


Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr Tyr Ser 
                325                 330                 335     


Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr Trp Asp 
            340                 345                 350         


His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro Cys Leu 
        355                 360                 365             


Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln Asn Tyr 
    370                 375                 380                 


Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys His Pro 
385                 390                 395                 400 


Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met Glu Asn 
                405                 410                 415     


Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys Ser Lys 
            420                 425                 430         


Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln Tyr Thr 
        435                 440                 445             


Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly Tyr Val 
    450                 455                 460                 


Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys Asp Gly 
465                 470                 475                 480 


Trp Ser Ala Gln Pro Thr Cys Ile Lys 
                485                 


<210>  7
<211>  1086
<212>  PRT
<213>  Homo sapiens

<400>  7

Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      


Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          


Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys 
        35                  40                  45              


Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  


Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  


Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      


Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         


Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             


Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 


Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 


Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     


Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         


Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             


Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 


Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 


Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn 
                245                 250                 255     


Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu Ile 
            260                 265                 270         


Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr 
        275                 280                 285             


Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr Leu 
    290                 295                 300                 


Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr His Glu 
305                 310                 315                 320 


Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr Tyr Ser 
                325                 330                 335     


Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr Trp Asp 
            340                 345                 350         


His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro Cys Leu 
        355                 360                 365             


Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln Asn Tyr 
    370                 375                 380                 


Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys His Pro 
385                 390                 395                 400 


Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met Glu Asn 
                405                 410                 415     


Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys Ser Lys 
            420                 425                 430         


Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln Tyr Thr 
        435                 440                 445             


Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly Tyr Val 
    450                 455                 460                 


Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys Asp Gly 
465                 470                 475                 480 


Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro Val Phe 
                485                 490                 495     


Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu Asn Asp 
            500                 505                 510         


Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr Gly Ser 
        515                 520                 525             


Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp Leu Pro 
    530                 535                 540                 


Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val His Leu 
545                 550                 555                 560 


Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val Leu Lys 
                565                 570                 575     


Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser Val Gln 
            580                 585                 590         


Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys Glu Gln 
        595                 600                 605             


Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn Val Lys 
    610                 615                 620                 


Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu Tyr Tyr 
625                 630                 635                 640 


Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln Cys Val 
                645                 650                 655     


Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu Ser Thr 
            660                 665                 670         


Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu Ser Ser 
        675                 680                 685             


Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser Glu Ser 
    690                 695                 700                 


Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly Val Trp 
705                 710                 715                 720 


Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys Cys Lys 
                725                 730                 735     


Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys Lys Glu 
            740                 745                 750         


Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys Glu Gly 
        755                 760                 765             


Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu Val Asn 
    770                 775                 780                 


Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln Ile Pro 
785                 790                 795                 800 


Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly Glu Lys 
                805                 810                 815     


Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly Glu Glu 
            820                 825                 830         


Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys Val Glu 
        835                 840                 845             


Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr Ile Asn 
    850                 855                 860                 


Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys Leu Ser 
865                 870                 875                 880 


Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu Thr Thr 
                885                 890                 895     


Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly Leu Pro 
            900                 905                 910         


Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His Met Ser 
        915                 920                 925             


Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe Glu Gly 
    930                 935                 940                 


Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu Lys Trp 
945                 950                 955                 960 


Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu Pro Ser 
                965                 970                 975     


Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr Lys Ala 
            980                 985                 990         


Gly Glu Gln Val Thr Tyr Thr Cys  Ala Thr Tyr Tyr Lys  Met Asp Gly 
        995                 1000                 1005             


Ala Ser  Asn Val Thr Cys Ile  Asn Ser Arg Trp Thr  Gly Arg Pro 
    1010                 1015                 1020             


Thr Cys  Arg Asp Thr Ser Cys  Val Asn Pro Pro Thr  Val Gln Asn 
    1025                 1030                 1035             


Ala Tyr  Ile Val Ser Arg Gln  Met Ser Lys Tyr Pro  Ser Gly Glu 
    1040                 1045                 1050             


Arg Val  Arg Tyr Gln Cys Arg  Ser Pro Tyr Glu Met  Phe Gly Asp 
    1055                 1060                 1065             


Glu Glu  Val Met Cys Leu Asn  Gly Asn Trp Thr Glu  Pro Pro Gln 
    1070                 1075                 1080             


Cys Lys  Asp 
    1085     


<210>  8
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  8

Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile 
1               5                   10                  15      


Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr 
            20                  25                  30          


Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys 
        35                  40                  45              


Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val 
    50                  55                  60                  


Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr 
65                  70                  75                  80  


Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val 
                85                  90                  95      


Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr 
            100                 105                 110         


Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg 
        115                 120                 125         


<210>  9
<211>  1234
<212>  PRT
<213>  Mus musculus

<400>  9

Met Arg Leu Ser Ala Arg Ile Ile Trp Leu Ile Leu Trp Thr Val Cys 
1               5                   10                  15      


Ala Ala Glu Asp Cys Lys Gly Pro Pro Pro Arg Glu Asn Ser Glu Ile 
            20                  25                  30          


Leu Ser Gly Ser Trp Ser Glu Gln Leu Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Thr Tyr Lys Cys Arg Pro Gly Tyr Arg Thr Leu Gly Thr Ile Val Lys 
    50                  55                  60                  


Val Cys Lys Asn Gly Lys Trp Val Ala Ser Asn Pro Ser Arg Ile Cys 
65                  70                  75                  80  


Arg Lys Lys Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Ser Phe 
                85                  90                  95      


Arg Leu Ala Val Gly Ser Gln Phe Glu Phe Gly Ala Lys Val Val Tyr 
            100                 105                 110         


Thr Cys Asp Asp Gly Tyr Gln Leu Leu Gly Glu Ile Asp Tyr Arg Glu 
        115                 120                 125             


Cys Gly Ala Asp Gly Trp Ile Asn Asp Ile Pro Leu Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Glu Leu Glu Asn Gly Arg Ile Val Ser Gly 
145                 150                 155                 160 


Ala Ala Glu Thr Asp Gln Glu Tyr Tyr Phe Gly Gln Val Val Arg Phe 
                165                 170                 175     


Glu Cys Asn Ser Gly Phe Lys Ile Glu Gly His Lys Glu Ile His Cys 
            180                 185                 190         


Ser Glu Asn Gly Leu Trp Ser Asn Glu Lys Pro Arg Cys Val Glu Ile 
        195                 200                 205             


Leu Cys Thr Pro Pro Arg Val Glu Asn Gly Asp Gly Ile Asn Val Lys 
    210                 215                 220                 


Pro Val Tyr Lys Glu Asn Glu Arg Tyr His Tyr Lys Cys Lys His Gly 
225                 230                 235                 240 


Tyr Val Pro Lys Glu Arg Gly Asp Ala Val Cys Thr Gly Ser Gly Trp 
                245                 250                 255     


Ser Ser Gln Pro Phe Cys Glu Glu Lys Arg Cys Ser Pro Pro Tyr Ile 
            260                 265                 270         


Leu Asn Gly Ile Tyr Thr Pro His Arg Ile Ile His Arg Ser Asp Asp 
        275                 280                 285             


Glu Ile Arg Tyr Glu Cys Asn Tyr Gly Phe Tyr Pro Val Thr Gly Ser 
    290                 295                 300                 


Thr Val Ser Lys Cys Thr Pro Thr Gly Trp Ile Pro Val Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Glu Phe Pro Gln Phe Lys Tyr Gly Arg Leu Tyr 
                325                 330                 335     


Tyr Glu Glu Ser Leu Arg Pro Asn Phe Pro Val Ser Ile Gly Asn Lys 
            340                 345                 350         


Tyr Ser Tyr Lys Cys Asp Asn Gly Phe Ser Pro Pro Ser Gly Tyr Ser 
        355                 360                 365             


Trp Asp Tyr Leu Arg Cys Thr Ala Gln Gly Trp Glu Pro Glu Val Pro 
    370                 375                 380                 


Cys Val Arg Lys Cys Val Phe His Tyr Val Glu Asn Gly Asp Ser Ala 
385                 390                 395                 400 


Tyr Trp Glu Lys Val Tyr Val Gln Gly Gln Ser Leu Lys Val Gln Cys 
                405                 410                 415     


Tyr Asn Gly Tyr Ser Leu Gln Asn Gly Gln Asp Thr Met Thr Cys Thr 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Pro Pro Lys Cys Ile Arg Ile Lys Thr Cys 
        435                 440                 445             


Ser Ala Ser Asp Ile His Ile Asp Asn Gly Phe Leu Ser Glu Ser Ser 
    450                 455                 460                 


Ser Ile Tyr Ala Leu Asn Arg Glu Thr Ser Tyr Arg Cys Lys Gln Gly 
465                 470                 475                 480 


Tyr Val Thr Asn Thr Gly Glu Ile Ser Gly Ser Ile Thr Cys Leu Gln 
                485                 490                 495     


Asn Gly Trp Ser Pro Gln Pro Ser Cys Ile Lys Ser Cys Asp Met Pro 
            500                 505                 510         


Val Phe Glu Asn Ser Ile Thr Lys Asn Thr Arg Thr Trp Phe Lys Leu 
        515                 520                 525             


Asn Asp Lys Leu Asp Tyr Glu Cys Leu Val Gly Phe Glu Asn Glu Tyr 
    530                 535                 540                 


Lys His Thr Lys Gly Ser Ile Thr Cys Thr Tyr Tyr Gly Trp Ser Asp 
545                 550                 555                 560 


Thr Pro Ser Cys Tyr Glu Arg Glu Cys Ser Val Pro Thr Leu Asp Arg 
                565                 570                 575     


Lys Leu Val Val Ser Pro Arg Lys Glu Lys Tyr Arg Val Gly Asp Leu 
            580                 585                 590         


Leu Glu Phe Ser Cys His Ser Gly His Arg Val Gly Pro Asp Ser Val 
        595                 600                 605             


Gln Cys Tyr His Phe Gly Trp Ser Pro Gly Phe Pro Thr Cys Lys Gly 
    610                 615                 620                 


Gln Val Ala Ser Cys Ala Pro Pro Leu Glu Ile Leu Asn Gly Glu Ile 
625                 630                 635                 640 


Asn Gly Ala Lys Lys Val Glu Tyr Ser His Gly Glu Val Val Lys Tyr 
                645                 650                 655     


Asp Cys Lys Pro Arg Phe Leu Leu Lys Gly Pro Asn Lys Ile Gln Cys 
            660                 665                 670         


Val Asp Gly Asn Trp Thr Thr Leu Pro Val Cys Ile Glu Glu Glu Arg 
        675                 680                 685             


Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Ser Ala Lys Cys Ser 
    690                 695                 700                 


Val Pro Pro Tyr His His Gly Asp Ser Val Glu Phe Ile Cys Glu Glu 
705                 710                 715                 720 


Asn Phe Thr Met Ile Gly His Gly Ser Val Ser Cys Ile Ser Gly Lys 
                725                 730                 735     


Trp Thr Gln Leu Pro Lys Cys Val Ala Thr Asp Gln Leu Glu Lys Cys 
            740                 745                 750         


Arg Val Leu Lys Ser Thr Gly Ile Glu Ala Ile Lys Pro Lys Leu Thr 
        755                 760                 765             


Glu Phe Thr His Asn Ser Thr Met Asp Tyr Lys Cys Arg Asp Lys Gln 
    770                 775                 780                 


Glu Tyr Glu Arg Ser Ile Cys Ile Asn Gly Lys Trp Asp Pro Glu Pro 
785                 790                 795                 800 


Asn Cys Thr Ser Lys Thr Ser Cys Pro Pro Pro Pro Gln Ile Pro Asn 
                805                 810                 815     


Thr Gln Val Ile Glu Thr Thr Val Lys Tyr Leu Asp Gly Glu Lys Leu 
            820                 825                 830         


Ser Val Leu Cys Gln Asp Asn Tyr Leu Thr Gln Asp Ser Glu Glu Met 
        835                 840                 845             


Val Cys Lys Asp Gly Arg Trp Gln Ser Leu Pro Arg Cys Ile Glu Lys 
    850                 855                 860                 


Ile Pro Cys Ser Gln Pro Pro Thr Ile Glu His Gly Ser Ile Asn Leu 
865                 870                 875                 880 


Pro Arg Ser Ser Glu Glu Arg Arg Asp Ser Ile Glu Ser Ser Ser His 
                885                 890                 895     


Glu His Gly Thr Thr Phe Ser Tyr Val Cys Asp Asp Gly Phe Arg Ile 
            900                 905                 910         


Pro Glu Glu Asn Arg Ile Thr Cys Tyr Met Gly Lys Trp Ser Thr Pro 
        915                 920                 925             


Pro Arg Cys Val Gly Leu Pro Cys Gly Pro Pro Pro Ser Ile Pro Leu 
    930                 935                 940                 


Gly Thr Val Ser Leu Glu Leu Glu Ser Tyr Gln His Gly Glu Glu Val 
945                 950                 955                 960 


Thr Tyr His Cys Ser Thr Gly Phe Gly Ile Asp Gly Pro Ala Phe Ile 
                965                 970                 975     


Ile Cys Glu Gly Gly Lys Trp Ser Asp Pro Pro Lys Cys Ile Lys Thr 
            980                 985                 990         


Asp Cys Asp Val Leu Pro Thr Val  Lys Asn Ala Ile Ile  Arg Gly Lys 
        995                 1000                 1005             


Ser Lys  Lys Ser Tyr Arg Thr  Gly Glu Gln Val Thr  Phe Arg Cys 
    1010                 1015                 1020             


Gln Ser  Pro Tyr Gln Met Asn  Gly Ser Asp Thr Val  Thr Cys Val 
    1025                 1030                 1035             


Asn Ser  Arg Trp Ile Gly Gln  Pro Val Cys Lys Asp  Asn Ser Cys 
    1040                 1045                 1050             


Val Asp  Pro Pro His Val Pro  Asn Ala Thr Ile Val  Thr Arg Thr 
    1055                 1060                 1065             


Lys Asn  Lys Tyr Leu His Gly  Asp Arg Val Arg Tyr  Glu Cys Asn 
    1070                 1075                 1080             


Lys Pro  Leu Glu Leu Phe Gly  Gln Val Glu Val Met  Cys Glu Asn 
    1085                 1090                 1095             


Gly Ile  Trp Thr Glu Lys Pro  Lys Cys Arg Asp Ser  Thr Gly Lys 
    1100                 1105                 1110             


Cys Gly  Pro Pro Pro Pro Ile  Asp Asn Gly Asp Ile  Thr Ser Leu 
    1115                 1120                 1125             


Ser Leu  Pro Val Tyr Glu Pro  Leu Ser Ser Val Glu  Tyr Gln Cys 
    1130                 1135                 1140             


Gln Lys  Tyr Tyr Leu Leu Lys  Gly Lys Lys Thr Ile  Thr Cys Thr 
    1145                 1150                 1155             


Asn Gly  Lys Trp Ser Glu Pro  Pro Thr Cys Leu His  Ala Cys Val 
    1160                 1165                 1170             


Ile Pro  Glu Asn Ile Met Glu  Ser His Asn Ile Ile  Leu Lys Trp 
    1175                 1180                 1185             


Arg His  Thr Glu Lys Ile Tyr  Ser His Ser Gly Glu  Asp Ile Glu 
    1190                 1195                 1200             


Phe Gly  Cys Lys Tyr Gly Tyr  Tyr Lys Ala Arg Asp  Ser Pro Pro 
    1205                 1210                 1215             


Phe Arg  Thr Lys Cys Ile Asn  Gly Thr Ile Asn Tyr  Pro Thr Cys 
    1220                 1225                 1230             


Val 
    


<210>  10
<211>  3705
<212>  DNA
<213>  Mus musculus

<400>  10
atgagactgt cagcaagaat tatttggctt atattatgga ctgtttgtgc agcagaagat     60

tgtaaaggtc ctcctccaag agaaaattca gaaattctct caggctcgtg gtcagaacaa    120

ctatatccag aaggcaccca ggctacctac aaatgccgcc ctggataccg aacacttggc    180

actattgtaa aagtatgcaa gaatggaaaa tgggtggcgt ctaacccatc caggatatgt    240

cggaaaaagc cttgtgggca tcccggagac acaccctttg ggtcctttag gctggcagtt    300

ggatctcaat ttgagtttgg tgcaaaggtt gtttatacct gtgatgatgg gtatcaacta    360

ttaggtgaaa ttgattaccg tgaatgtggt gcagatggct ggatcaatga tattccacta    420

tgtgaagttg tgaagtgtct acctgtgaca gaactcgaga atggaagaat tgtgagtggt    480

gcagcagaaa cagaccagga atactatttt ggacaggtgg tgcggtttga atgcaattca    540

ggcttcaaga ttgaaggaca taaggaaatt cattgctcag aaaatggcct ttggagcaat    600

gaaaagccac gatgtgtgga aattctctgc acaccaccgc gagtggaaaa tggagatggt    660

ataaatgtga aaccagttta caaggagaat gaaagatacc actataagtg taagcatggt    720

tatgtgccca aagaaagagg ggatgccgtc tgcacaggct ctggatggag ttctcagcct    780

ttctgtgaag aaaagagatg ctcacctcct tatattctaa atggtatcta cacacctcac    840

aggattatac acagaagtga tgatgaaatc agatatgaat gtaattatgg cttctatcct    900

gtaactggat caactgtttc aaagtgtaca cccactggct ggatccctgt tccaagatgt    960

accttgaaac catgtgaatt tccacaattc aaatatggac gtctgtatta tgaagagagc   1020

ctgagaccca acttcccagt atctatagga aataagtaca gctataagtg tgacaacggg   1080

ttttcaccac cttctgggta ttcctgggac taccttcgtt gcacagcaca agggtgggag   1140

cctgaagtcc catgcgtcag gaaatgtgtt ttccattatg tggagaatgg agactctgca   1200

tactgggaaa aagtatatgt gcagggtcag tctttaaaag tccagtgtta caatggctat   1260

agtcttcaaa atggtcaaga cacaatgaca tgtacagaga atggctggtc ccctcctccc   1320

aaatgcatcc gtatcaagac atgttcagca tcagatatac acattgacaa tggatttctt   1380

tctgaatctt cttctatata tgctctaaat agagaaacat cctatagatg taagcaggga   1440

tatgtgacaa atactggaga aatatcagga tcaataactt gccttcaaaa tggatggtca   1500

cctcaaccct catgcattaa gtcttgtgat atgcctgtat ttgagaattc tataactaag   1560

aatactagga catggtttaa gctcaatgac aaattagact atgaatgtct cgttggattt   1620

gaaaatgaat ataaacatac caaaggctct ataacatgta cttattatgg atggtctgat   1680

acaccctcat gttatgaaag agaatgcagt gttcccactc tagaccgaaa actagtcgtt   1740

tcccccagaa aagaaaaata cagagttgga gatttgttgg aattctcctg ccattcagga   1800

cacagagttg ggccagattc agtgcaatgc taccactttg gatggtctcc tggtttccct   1860

acatgtaaag gtcaagtagc atcatgtgca ccacctcttg aaattcttaa tggggaaatt   1920

aatggagcaa aaaaagttga atacagccat ggtgaagtgg tgaaatatga ttgcaaacct   1980

agattcctac tgaagggacc caataaaatc cagtgtgttg atgggaattg gacaaccttg   2040

cctgtatgta ttgaggagga gagaacatgt ggagacattc ctgaacttga acatggctct   2100

gccaagtgtt ctgttcctcc ctaccaccat ggagattcag tggagttcat ttgtgaagaa   2160

aacttcacaa tgattggaca tgggtcagtt tcttgcatta gtggaaaatg gacccagctt   2220

cctaaatgtg ttgcaacaga ccaactggag aagtgtagag tgctgaagtc aactggcata   2280

gaagcaataa aaccaaaatt gactgaattt acgcataact ccaccatgga ttacaaatgt   2340

agagacaagc aggagtacga acgctcaatc tgtatcaatg gaaaatggga tcctgaacca   2400

aactgtacaa gcaaaacatc ctgccctcct ccaccgcaga ttccaaatac ccaagtgatt   2460

gaaaccaccg tgaaatactt ggatggagaa aaattatctg ttctttgcca agacaattac   2520

ctaactcagg actcagaaga aatggtgtgc aaagatggaa ggtggcagtc attacctcgc   2580

tgcattgaaa aaattccatg ttcccagccc cctacaatag aacatggatc tattaattta   2640

cccagatctt cagaagaaag gagagattcc attgagtcca gcagtcatga acatggaact   2700

acattcagct atgtctgtga tgatggtttc aggatacctg aagaaaatag gataacctgc   2760

tacatgggaa aatggagcac tccacctcgc tgtgttggac ttccttgtgg acctccacct   2820

tcaattcctc ttggtactgt ttctcttgag ctagagagtt accaacatgg ggaagaggtt   2880

acataccatt gttctacagg ctttggaatt gatggaccag catttattat atgcgaagga   2940

ggaaagtggt ctgacccacc aaaatgcata aaaacggatt gtgacgtttt acccacagtt   3000

aaaaatgcca taataagagg aaagagcaaa aaatcatata ggacaggaga acaagtgaca   3060

ttcagatgtc aatctcctta tcaaatgaat ggctcagaca ctgtgacatg tgttaatagt   3120

cggtggattg gacagccagt atgcaaagat aattcctgtg tggatccacc acatgtgcca   3180

aatgctacta tagtaacaag gaccaagaat aaatatctac atggtgacag agtacgttat   3240

gaatgtaata aacctttgga actatttggg caagtggaag tgatgtgtga aaatgggata   3300

tggacagaaa aaccaaagtg ccgagactca acagggaaat gtgggcctcc tccacctatt   3360

gacaatggag acatcacctc cttgtcatta ccagtatatg aaccattatc atcagttgaa   3420

tatcaatgcc agaagtatta tctccttaag ggaaagaaga caataacatg tacaaatgga   3480

aagtggtctg agccaccaac atgcttacat gcatgtgtaa taccagaaaa cattatggaa   3540

tcacacaata taattctcaa atggagacac actgaaaaga tttattccca ttcaggggag   3600

gatattgaat ttggatgtaa atatggatat tataaagcaa gagattcacc gccatttcgt   3660

acaaagtgca ttaatggcac catcaattat cccacttgtg tataa                   3705


<210>  11
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser 
            20      


<210>  12
<211>  72
<212>  DNA
<213>  Homo sapiens

<400>  12
atgcccatgg ggtctctgca accgctggcc accttgtacc tgctggggat gctggtcgct     60

tcctgcctcg ga                                                         72


<210>  13
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Gly Ala Ala Gly Leu Leu Gly Val Phe Leu Ala Leu Val Ala Pro 
1               5                   10                  15      


Gly 
    


<210>  14
<211>  51
<212>  DNA
<213>  Homo sapiens

<400>  14
atgggcgccg cgggcctgct cggggttttc ttggctctcg tcgcaccggg g              51


<210>  15
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Gly Ala Ala Gly Leu Leu Gly Val Phe Leu Ala Leu Val Ala Pro 
1               5                   10                  15      


Gly Val Leu Gly 
            20  


<210>  16
<211>  60
<212>  DNA
<213>  Homo sapiens

<400>  16
atgggagccg ctggtctgct cggcgtgttc ctcgccttgg tggcacctgg cgtcctgggc     60


<210>  17
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 
1               5                   10                  15      


Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 
            20                  25                  30          


Trp Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala 
        35                  40                  45              


Leu Glu Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys 
    50                  55                  60                  


Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile 
65                  70                  75                  80  


Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg 
                85                  90                  95      


Ser Cys Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro 
            100                 105                 110         


Tyr Ile Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu 
        115                 120                 125             


Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr 
    130                 135                 140                 


Cys Leu Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys 
145                 150                 155                 160 


Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val 
                165                 170                 175     


Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr 
            180                 185                 190         


Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly 
        195                 200                 205             


Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr 
    210                 215                 220                 


Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg 
225                 230                 235                 240 


Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly 
                245                 250                 255     


Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp 
            260                 265                 270         


Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu 
        275                 280                 285             


Thr Ser Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val 
    290                 295                 300                 


Pro Thr Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr 
305                 310                 315                 320 


Thr Thr Pro Asn Ala Gln Ala Thr Arg Ser Thr Pro Val Ser Arg Thr 
                325                 330                 335     


Thr Lys His Phe His Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr 
            340                 345                 350         


Ser Gly Thr Thr Arg Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr 
        355                 360                 365             


Gly Leu Leu Gly Thr Leu Val Thr Met Gly Leu Leu Thr 
    370                 375                 380     


<210>  18
<211>  1146
<212>  DNA
<213>  Homo sapiens

<400>  18
atgaccgtcg cgcggccgag cgtgcccgcg gcgctgcccc tcctcgggga gctgccccgg     60

ctgctgctgc tggtgctgtt gtgcctgccg gccgtgtggg gtgactgtgg ccttccccca    120

gatgtaccta atgcccagcc agctttggaa ggccgtacaa gttttcccga ggatactgta    180

ataacgtaca aatgtgaaga aagctttgtg aaaattcctg gcgagaagga ctcagtgatc    240

tgccttaagg gcagtcaatg gtcagatatt gaagagttct gcaatcgtag ctgcgaggtg    300

ccaacaaggc taaattctgc atccctcaaa cagccttata tcactcagaa ttattttcca    360

gtcggtactg ttgtggaata tgagtgccgt ccaggttaca gaagagaacc ttctctatca    420

ccaaaactaa cttgccttca gaatttaaaa tggtccacag cagtcgaatt ttgtaaaaag    480

aaatcatgcc ctaatccggg agaaatacga aatggtcaga ttgatgtacc aggtggcata    540

ttatttggtg caaccatctc cttctcatgt aacacagggt acaaattatt tggctcgact    600

tctagttttt gtcttatttc aggcagctct gtccagtgga gtgacccgtt gccagagtgc    660

agagaaattt attgtccagc accaccacaa attgacaatg gaataattca aggggaacgt    720

gaccattatg gatatagaca gtctgtaacg tatgcatgta ataaaggatt caccatgatt    780

ggagagcact ctatttattg tactgtgaat aatgatgaag gagagtggag tggcccacca    840

cctgaatgca gaggaaaatc tctaacttcc aaggtcccac caacagttca gaaacctacc    900

acagtaaatg ttccaactac agaagtctca ccaacttctc agaaaaccac cacaaaaacc    960

accacaccaa atgctcaagc aacacggagt acacctgttt ccaggacaac caagcatttt   1020

catgaaacaa ccccaaataa aggaagtgga accacttcag gtactacccg tcttctatct   1080

gggcacacgt gtttcacgtt gacaggtttg cttgggacgc tagtaaccat gggcttgctg   1140

acttag                                                              1146


<210>  19
<211>  392
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Glu Pro Pro Gly Arg Arg Glu Cys Pro Phe Pro Ser Trp Arg Phe 
1               5                   10                  15      


Pro Gly Leu Leu Leu Ala Ala Met Val Leu Leu Leu Tyr Ser Phe Ser 
            20                  25                  30          


Asp Ala Cys Glu Glu Pro Pro Thr Phe Glu Ala Met Glu Leu Ile Gly 
        35                  40                  45              


Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys 
    50                  55                  60                  


Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Thr His Thr Ile Cys 
65                  70                  75                  80  


Asp Arg Asn His Thr Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg 
                85                  90                  95      


Glu Thr Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro 
            100                 105                 110         


Ala Asn Gly Thr Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn 
        115                 120                 125             


Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys 
    130                 135                 140                 


Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val 
145                 150                 155                 160 


Leu Cys Thr Pro Pro Pro Lys Ile Lys Asn Gly Lys His Thr Phe Ser 
                165                 170                 175     


Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Thr Tyr Ser Cys Asp 
            180                 185                 190         


Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Thr Ile 
        195                 200                 205             


Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys 
    210                 215                 220                 


Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser 
225                 230                 235                 240 


Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Thr Val Met Phe Glu Cys 
                245                 250                 255     


Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Thr Ile Val Cys Asp Ser 
            260                 265                 270         


Asn Ser Thr Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Val Leu Pro 
        275                 280                 285             


Pro Ser Ser Thr Lys Pro Pro Ala Leu Ser His Ser Val Ser Thr Ser 
    290                 295                 300                 


Ser Thr Thr Lys Ser Pro Ala Ser Ser Ala Ser Gly Pro Arg Pro Thr 
305                 310                 315                 320 


Tyr Lys Pro Pro Val Ser Asn Tyr Pro Gly Tyr Pro Lys Pro Glu Glu 
                325                 330                 335     


Gly Ile Leu Asp Ser Leu Asp Val Trp Val Ile Ala Val Ile Val Ile 
            340                 345                 350         


Ala Ile Val Val Gly Val Ala Val Ile Cys Val Val Pro Tyr Arg Tyr 
        355                 360                 365             


Leu Gln Arg Arg Lys Lys Lys Gly Thr Tyr Leu Thr Asp Glu Thr His 
    370                 375                 380                 


Arg Glu Val Lys Phe Thr Ser Leu 
385                 390         


<210>  20
<211>  1134
<212>  DNA
<213>  Homo sapiens

<400>  20
atggagcctc ccggccgccg cgagtgtccc tttccttcct ggcgctttcc tgggttgctt     60

ctggcggcca tggtgttgct gctgtactcc ttctccgatg cctgtgagga gccaccaaca    120

tttgaagcta tggagctcat tggtaaacca aaaccctact atgagattgg tgaacgagta    180

gattataagt gtaaaaaagg atacttctat atacctcctc ttgccaccca tactatttgt    240

gatcggaatc atacatggct acctgtctca gatgacgcct gttatagaga aacatgtcca    300

tatatacggg atcctttaaa tggccaagca gtccctgcaa atgggactta cgagtttggt    360

tatcagatgc actttatttg taatgagggt tattacttaa ttggtgaaga aattctatat    420

tgtgaactta aaggatcagt agcaatttgg agcggtaagc ccccaatatg tgaaaaggtt    480

ttgtgtacac cacctccaaa aataaaaaat ggaaaacaca cctttagtga agtagaagta    540

tttgagtatc ttgatgcagt aacttatagt tgtgatcctg cacctggacc agatccattt    600

tcacttattg gagagagcac gatttattgt ggtgacaatt cagtgtggag tcgtgctgct    660

ccagagtgta aagtggtcaa atgtcgattt ccagtagtcg aaaatggaaa acagatatca    720

ggatttggaa aaaaatttta ctacaaagca acagttatgt ttgaatgcga taagggtttt    780

tacctcgatg gcagcgacac aattgtctgt gacagtaaca gtacttggga tcccccagtt    840

ccaaagtgtc ttaaagtgtc gacttcttcc actacaaaat ctccagcgtc cagtgcctca    900

ggtcctaggc ctacttacaa gcctccagtc tcaaattatc caggatatcc taaacctgag    960

gaaggaatac ttgacagttt ggatgtttgg gtcattgctg tgattgttat tgccatagtt   1020

gttggagttg cagtaatttg tgttgtcccg tacagatatc ttcaaaggag gaagaagaaa   1080

ggcacatacc taactgatga gacccacaga gaagtaaaat ttacttctct ctga         1134


<210>  21
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Phe Cys His Ser Gly His Ser Leu Gln Cys Tyr Asn Cys Pro 
            20                  25                  30          


Asn Pro Thr Ala Asp Cys Lys Thr Ala Val Asn Cys Ser Ser Asp Phe 
        35                  40                  45              


Asp Ala Cys Leu Ile Thr Lys Ala Gly Leu Gln Val Tyr Asn Lys Cys 
    50                  55                  60                  


Trp Lys Phe Glu His Cys Asn Phe Asn Asp Val Thr Thr Arg Leu Arg 
65                  70                  75                  80  


Glu Asn Glu Leu Thr Tyr Tyr Cys Cys Lys Lys Asp Leu Cys Asn Phe 
                85                  90                  95      


Asn Glu Gln Leu Glu Asn Gly Gly Thr Ser Leu Ser Glu Lys Thr Val 
            100                 105                 110         


Leu Leu Leu Val Thr Pro Phe Leu Ala Ala Ala Trp Ser Leu His Pro 
        115                 120                 125             


<210>  22
<211>  387
<212>  DNA
<213>  Homo sapiens

<400>  22
atgggaatcc aaggagggtc tgtcctgttc gggctgctgc tcgtcctggc tgtcttctgc     60

cattcaggtc atagcctgca gtgctacaac tgtcctaacc caactgctga ctgcaaaaca    120

gccgtcaatt gttcatctga ttttgatgcg tgtctcatta ccaaagctgg gttacaagtg    180

tataacaagt gttggaagtt tgagcattgc aatttcaacg acgtcacaac ccgcttgagg    240

gaaaatgagc taacgtacta ctgctgcaag aaggacctgt gtaactttaa cgaacagctt    300

gaaaatggtg ggacatcctt atcagagaaa acagttcttc tgctggtgac tccatttctg    360

gcagcagcct ggagccttca tccctaa                                        387


<210>  23
<211>  2039
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala 
1               5                   10                  15      


Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val 
            20                  25                  30          


Leu Leu Ala Leu Pro Val Ala Trp Gly Gln Cys Asn Ala Pro Glu Trp 
        35                  40                  45              


Leu Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro 
    50                  55                  60                  


Ile Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg 
65                  70                  75                  80  


Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys 
                85                  90                  95      


Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn 
            100                 105                 110         


Gly Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys 
        115                 120                 125             


Tyr Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr 
    130                 135                 140                 


Cys Ile Ile Ser Gly Asp Thr Val Ile Trp Asp Asn Glu Thr Pro Ile 
145                 150                 155                 160 


Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp 
                165                 170                 175     


Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr 
            180                 185                 190         


Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val 
        195                 200                 205             


Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile 
    210                 215                 220                 


Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro 
225                 230                 235                 240 


Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe 
                245                 250                 255     


Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met 
            260                 265                 270         


Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro 
        275                 280                 285             


Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu 
    290                 295                 300                 


His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln 
305                 310                 315                 320 


Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala 
                325                 330                 335     


Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Thr 
            340                 345                 350         


Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly 
        355                 360                 365             


Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe 
    370                 375                 380                 


Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys 
385                 390                 395                 400 


Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys 
                405                 410                 415     


Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His 
            420                 425                 430         


Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Ala Val Asn Tyr 
        435                 440                 445             


Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile Gly 
    450                 455                 460                 


Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp 
465                 470                 475                 480 


Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro 
                485                 490                 495     


Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp 
            500                 505                 510         


Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr 
        515                 520                 525             


Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser 
    530                 535                 540                 


Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro 
545                 550                 555                 560 


Val Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg 
                565                 570                 575     


Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser 
            580                 585                 590         


Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Thr Lys Pro 
        595                 600                 605             


Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn 
    610                 615                 620                 


Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val 
625                 630                 635                 640 


Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu 
                645                 650                 655     


Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val 
            660                 665                 670         


Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys 
        675                 680                 685             


Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser 
    690                 695                 700                 


Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe 
705                 710                 715                 720 


Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp 
                725                 730                 735     


Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp 
            740                 745                 750         


Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro 
        755                 760                 765             


Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly 
    770                 775                 780                 


Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala 
785                 790                 795                 800 


Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu 
                805                 810                 815     


Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val 
            820                 825                 830         


Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser 
        835                 840                 845             


Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro 
    850                 855                 860                 


Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly 
865                 870                 875                 880 


Arg His Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Ala Val 
                885                 890                 895     


Asn Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu 
            900                 905                 910         


Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly 
        915                 920                 925             


Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln 
    930                 935                 940                 


Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala 
945                 950                 955                 960 


Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu 
                965                 970                 975     


Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp 
            980                 985                 990         


Ser Ser Pro Lys Asp Val Cys Lys  Arg Lys Ser Cys Lys  Thr Pro Pro 
        995                 1000                 1005             


Asp Pro  Val Asn Gly Met Val  His Val Ile Thr Asp  Ile Gln Val 
    1010                 1015                 1020             


Gly Ser  Arg Ile Asn Tyr Ser  Cys Thr Thr Gly His  Arg Leu Ile 
    1025                 1030                 1035             


Gly His  Ser Ser Ala Glu Cys  Ile Leu Ser Gly Asn  Thr Ala His 
    1040                 1045                 1050             


Trp Ser  Thr Lys Pro Pro Ile  Cys Gln Arg Ile Pro  Cys Gly Leu 
    1055                 1060                 1065             


Pro Pro  Thr Ile Ala Asn Gly  Asp Phe Ile Ser Thr  Asn Arg Glu 
    1070                 1075                 1080             


Asn Phe  His Tyr Gly Ser Val  Val Thr Tyr Arg Cys  Asn Leu Gly 
    1085                 1090                 1095             


Ser Arg  Gly Arg Lys Val Phe  Glu Leu Val Gly Glu  Pro Ser Ile 
    1100                 1105                 1110             


Tyr Cys  Thr Ser Asn Asp Asp  Gln Val Gly Ile Trp  Ser Gly Pro 
    1115                 1120                 1125             


Ala Pro  Gln Cys Ile Ile Pro  Asn Lys Cys Thr Pro  Pro Asn Val 
    1130                 1135                 1140             


Glu Asn  Gly Ile Leu Val Ser  Asp Asn Arg Ser Leu  Phe Ser Leu 
    1145                 1150                 1155             


Asn Glu  Val Val Glu Phe Arg  Cys Gln Pro Gly Phe  Val Met Lys 
    1160                 1165                 1170             


Gly Pro  Arg Arg Val Lys Cys  Gln Ala Leu Asn Lys  Trp Glu Pro 
    1175                 1180                 1185             


Glu Leu  Pro Ser Cys Ser Arg  Val Cys Gln Pro Pro  Pro Glu Ile 
    1190                 1195                 1200             


Leu His  Gly Glu His Thr Pro  Ser His Gln Asp Asn  Phe Ser Pro 
    1205                 1210                 1215             


Gly Gln  Glu Val Phe Tyr Ser  Cys Glu Pro Gly Tyr  Asp Leu Arg 
    1220                 1225                 1230             


Gly Ala  Ala Ser Leu His Cys  Thr Pro Gln Gly Asp  Trp Ser Pro 
    1235                 1240                 1245             


Glu Ala  Pro Arg Cys Ala Val  Lys Ser Cys Asp Asp  Phe Leu Gly 
    1250                 1255                 1260             


Gln Leu  Pro His Gly Arg Val  Leu Phe Pro Leu Asn  Leu Gln Leu 
    1265                 1270                 1275             


Gly Ala  Lys Val Ser Phe Val  Cys Asp Glu Gly Phe  Arg Leu Lys 
    1280                 1285                 1290             


Gly Ser  Ser Val Ser His Cys  Val Leu Val Gly Met  Arg Ser Leu 
    1295                 1300                 1305             


Trp Asn  Asn Ser Val Pro Val  Cys Glu His Ile Phe  Cys Pro Asn 
    1310                 1315                 1320             


Pro Pro  Ala Ile Leu Asn Gly  Arg His Thr Gly Thr  Pro Ser Gly 
    1325                 1330                 1335             


Asp Ile  Pro Tyr Gly Lys Glu  Ile Ser Tyr Thr Cys  Asp Pro His 
    1340                 1345                 1350             


Pro Asp  Arg Gly Met Thr Phe  Asn Leu Ile Gly Glu  Ser Thr Ile 
    1355                 1360                 1365             


Arg Cys  Thr Ser Asp Pro His  Gly Asn Gly Val Trp  Ser Ser Pro 
    1370                 1375                 1380             


Ala Pro  Arg Cys Glu Leu Ser  Val Arg Ala Gly His  Cys Lys Thr 
    1385                 1390                 1395             


Pro Glu  Gln Phe Pro Phe Ala  Ser Pro Thr Ile Pro  Ile Asn Asp 
    1400                 1405                 1410             


Phe Glu  Phe Pro Val Gly Thr  Ser Leu Asn Tyr Glu  Cys Arg Pro 
    1415                 1420                 1425             


Gly Tyr  Phe Gly Lys Met Phe  Ser Ile Ser Cys Leu  Glu Asn Leu 
    1430                 1435                 1440             


Val Trp  Ser Ser Val Glu Asp  Asn Cys Arg Arg Lys  Ser Cys Gly 
    1445                 1450                 1455             


Pro Pro  Pro Glu Pro Phe Asn  Gly Met Val His Ile  Asn Thr Asp 
    1460                 1465                 1470             


Thr Gln  Phe Gly Ser Thr Val  Asn Tyr Ser Cys Asn  Glu Gly Phe 
    1475                 1480                 1485             


Arg Leu  Ile Gly Ser Pro Ser  Thr Thr Cys Leu Val  Ser Gly Asn 
    1490                 1495                 1500             


Asn Val  Thr Trp Asp Lys Lys  Ala Pro Ile Cys Glu  Ile Ile Ser 
    1505                 1510                 1515             


Cys Glu  Pro Pro Pro Thr Ile  Ser Asn Gly Asp Phe  Tyr Ser Asn 
    1520                 1525                 1530             


Asn Arg  Thr Ser Phe His Asn  Gly Thr Val Val Thr  Tyr Gln Cys 
    1535                 1540                 1545             


His Thr  Gly Pro Asp Gly Glu  Gln Leu Phe Glu Leu  Val Gly Glu 
    1550                 1555                 1560             


Arg Ser  Ile Tyr Cys Thr Ser  Lys Asp Asp Gln Val  Gly Val Trp 
    1565                 1570                 1575             


Ser Ser  Pro Pro Pro Arg Cys  Ile Ser Thr Asn Lys  Cys Thr Ala 
    1580                 1585                 1590             


Pro Glu  Val Glu Asn Ala Ile  Arg Val Pro Gly Asn  Arg Ser Phe 
    1595                 1600                 1605             


Phe Ser  Leu Thr Glu Ile Ile  Arg Phe Arg Cys Gln  Pro Gly Phe 
    1610                 1615                 1620             


Val Met  Val Gly Ser His Thr  Val Gln Cys Gln Thr  Asn Gly Arg 
    1625                 1630                 1635             


Trp Gly  Pro Lys Leu Pro His  Cys Ser Arg Val Cys  Gln Pro Pro 
    1640                 1645                 1650             


Pro Glu  Ile Leu His Gly Glu  His Thr Leu Ser His  Gln Asp Asn 
    1655                 1660                 1665             


Phe Ser  Pro Gly Gln Glu Val  Phe Tyr Ser Cys Glu  Pro Ser Tyr 
    1670                 1675                 1680             


Asp Leu  Arg Gly Ala Ala Ser  Leu His Cys Thr Pro  Gln Gly Asp 
    1685                 1690                 1695             


Trp Ser  Pro Glu Ala Pro Arg  Cys Thr Val Lys Ser  Cys Asp Asp 
    1700                 1705                 1710             


Phe Leu  Gly Gln Leu Pro His  Gly Arg Val Leu Leu  Pro Leu Asn 
    1715                 1720                 1725             


Leu Gln  Leu Gly Ala Lys Val  Ser Phe Val Cys Asp  Glu Gly Phe 
    1730                 1735                 1740             


Arg Leu  Lys Gly Arg Ser Ala  Ser His Cys Val Leu  Ala Gly Met 
    1745                 1750                 1755             


Lys Ala  Leu Trp Asn Ser Ser  Val Pro Val Cys Glu  Gln Ile Phe 
    1760                 1765                 1770             


Cys Pro  Asn Pro Pro Ala Ile  Leu Asn Gly Arg His  Thr Gly Thr 
    1775                 1780                 1785             


Pro Phe  Gly Asp Ile Pro Tyr  Gly Lys Glu Ile Ser  Tyr Ala Cys 
    1790                 1795                 1800             


Asp Thr  His Pro Asp Arg Gly  Met Thr Phe Asn Leu  Ile Gly Glu 
    1805                 1810                 1815             


Ser Ser  Ile Arg Cys Thr Ser  Asp Pro Gln Gly Asn  Gly Val Trp 
    1820                 1825                 1830             


Ser Ser  Pro Ala Pro Arg Cys  Glu Leu Ser Val Pro  Ala Ala Cys 
    1835                 1840                 1845             


Pro His  Pro Pro Lys Ile Gln  Asn Gly His Tyr Ile  Gly Gly His 
    1850                 1855                 1860             


Val Ser  Leu Tyr Leu Pro Gly  Met Thr Ile Ser Tyr  Thr Cys Asp 
    1865                 1870                 1875             


Pro Gly  Tyr Leu Leu Val Gly  Lys Gly Phe Ile Phe  Cys Thr Asp 
    1880                 1885                 1890             


Gln Gly  Ile Trp Ser Gln Leu  Asp His Tyr Cys Lys  Glu Val Asn 
    1895                 1900                 1905             


Cys Ser  Phe Pro Leu Phe Met  Asn Gly Ile Ser Lys  Glu Leu Glu 
    1910                 1915                 1920             


Met Lys  Lys Val Tyr His Tyr  Gly Asp Tyr Val Thr  Leu Lys Cys 
    1925                 1930                 1935             


Glu Asp  Gly Tyr Thr Leu Glu  Gly Ser Pro Trp Ser  Gln Cys Gln 
    1940                 1945                 1950             


Ala Asp  Asp Arg Trp Asp Pro  Pro Leu Ala Lys Cys  Thr Ser Arg 
    1955                 1960                 1965             


Ala His  Asp Ala Leu Ile Val  Gly Thr Leu Ser Gly  Thr Ile Phe 
    1970                 1975                 1980             


Phe Ile  Leu Leu Ile Ile Phe  Leu Ser Trp Ile Ile  Leu Lys His 
    1985                 1990                 1995             


Arg Lys  Gly Asn Asn Ala His  Glu Asn Pro Lys Glu  Val Ala Ile 
    2000                 2005                 2010             


His Leu  His Ser Gln Gly Gly  Ser Ser Val His Pro  Arg Thr Leu 
    2015                 2020                 2025             


Gln Thr  Asn Glu Glu Asn Ser  Arg Val Leu Pro 
    2030                 2035                 


<210>  24
<211>  6120
<212>  DNA
<213>  Homo sapiens

<400>  24
atgggggcct cttctccaag aagcccggag cctgtcgggc cgccggcgcc cggtctcccc     60

ttctgctgcg gaggatccct gctggcggtt gtggtgctgc ttgcgctgcc ggtggcctgg    120

ggtcaatgca atgccccaga atggcttcca tttgccaggc ctaccaacct aactgatgaa    180

tttgagtttc ccattgggac atatctgaac tatgaatgcc gccctggtta ttccggaaga    240

ccgttttcta tcatctgcct aaaaaactca gtctggactg gtgctaagga caggtgcaga    300

cgtaaatcat gtcgtaatcc tccagatcct gtgaatggca tggtgcatgt gatcaaaggc    360

atccagttcg gatcccaaat taaatattct tgtactaaag gataccgact cattggttcc    420

tcgtctgcca catgcatcat ctcaggtgat actgtcattt gggataatga aacacctatt    480

tgtgacagaa ttccttgtgg gctacccccc accatcacca atggagattt cattagcacc    540

aacagagaga attttcacta tggatcagtg gtgacctacc gctgcaatcc tggaagcgga    600

gggagaaagg tgtttgagct tgtgggtgag ccctccatat actgcaccag caatgacgat    660

caagtgggca tctggagcgg ccccgcccct cagtgcatta tacctaacaa atgcacgcct    720

ccaaatgtgg aaaatggaat attggtatct gacaacagaa gcttattttc cttaaatgaa    780

gttgtggagt ttaggtgtca gcctggcttt gtcatgaaag gaccccgccg tgtgaagtgc    840

caggccctga acaaatggga gccggagcta ccaagctgct ccagggtatg tcagccacct    900

ccagatgtcc tgcatgctga gcgtacccaa agggacaagg acaacttttc acctgggcag    960

gaagtgttct acagctgtga gcccggctac gacctcagag gggctgcgtc tatgcgctgc   1020

acaccccagg gagactggag ccctgcagcc cccacatgtg aagtgaaatc ctgtgatgac   1080

ttcatgggcc aacttcttaa tggccgtgtg ctatttccag taaatctcca gcttggagca   1140

aaagtggatt ttgtttgtga tgaaggattt caattaaaag gcagctctgc tagttactgt   1200

gtcttggctg gaatggaaag cctttggaat agcagtgttc cagtgtgtga acaaatcttt   1260

tgtccaagtc ctccagttat tcctaatggg agacacacag gaaaacctct ggaagtcttt   1320

ccctttggaa aagcagtaaa ttacacatgc gacccccacc cagacagagg gacgagcttc   1380

gacctcattg gagagagcac catccgctgc acaagtgacc ctcaagggaa tggggtttgg   1440

agcagccctg cccctcgctg tggaattctg ggtcactgtc aagccccaga tcattttctg   1500

tttgccaagt tgaaaaccca aaccaatgca tctgactttc ccattgggac atctttaaag   1560

tacgaatgcc gtcctgagta ctacgggagg ccattctcta tcacatgtct agataacctg   1620

gtctggtcaa gtcccaaaga tgtctgtaaa cgtaaatcat gtaaaactcc tccagatcca   1680

gtgaatggca tggtgcatgt gatcacagac atccaggttg gatccagaat caactattct   1740

tgtactacag ggcaccgact cattggtcac tcatctgctg aatgtatcct ctcgggcaat   1800

gctgcccatt ggagcacgaa gccgccaatt tgtcaacgaa ttccttgtgg gctacccccc   1860

accatcgcca atggagattt cattagcacc aacagagaga attttcacta tggatcagtg   1920

gtgacctacc gctgcaatcc tggaagcgga gggagaaagg tgtttgagct tgtgggtgag   1980

ccctccatat actgcaccag caatgacgat caagtgggca tctggagcgg cccggcccct   2040

cagtgcatta yacctaacaa atgcacgcct ccaaatgtgg aaaatggaat attggtatct   2100

gacaacagaa gcttattttc cttaaatgaa gttgtggagt ttaggtgtca gcctggcttt   2160

gtcatgaaag gaccccgccg tgtgaagtgc caggccctga acaaatggga gccggagcta   2220

ccaagctgct ccagggtatg tcagccacct ccagatgtcc tgcatgctga gcgtacccaa   2280

agggacaagg acaacttttc acccgggcag gaagtgttct acagctgtga gcccggctay   2340

gacctcagag gggctgcgtc tatgcgctgc acaccccagg gagactggag ccctgcagcc   2400

cccacatgtg aagtgaaatc ctgtgatgac ttcatgggcc aacttcttaa tggccgtgtg   2460

ctatttccag taaatctcca gcttggagca aaagtggatt ttgtttgtga tgaaggattt   2520

caattaaaag gcagctctgc tagttattgt gtcttggctg gaatggaaag cctttggaat   2580

agcagtgttc cagtgtgtga acaaatcttt tgtccaagtc ctccagttat tcctaatggg   2640

agacacacag gaaaacctct ggaagtcttt ccctttggaa aagcagtaaa ttacacatgc   2700

gacccccacc cagacagagg gacgagcttc gacctcattg gagagagcac catccgctgc   2760

acaagtgacc ctcaagggaa tggggtttgg agcagccctg cccctcgctg tggaattctg   2820

ggtcactgtc aagccccaga tcattttctg tttgccaagt tgaaaaccca aaccaatgca   2880

tctgactttc ccattgggac atctttaaag tacgaatgcc gtcctgagta ctacgggagg   2940

ccattctcta tcacatgtct agataacctg gtctggtcaa gtcccaaaga tgtctgtaaa   3000

cgtaaatcat gtaaaactcc tccagatcca gtgaatggca tggtgcatgt gatcacagac   3060

atccakgttg gatccagaat caactattct tgtactacag ggcaccgact cattggtcac   3120

tcatctgctg aatgtatcct ctcaggcaat actgcccatt ggagcacgaa gccgccaatt   3180

tgtcaacgaa ttccttgtgg gctaccccca accatcgcca atggagattt cattagcacc   3240

aacagagaga attttcacta tggatcagtg gtgacctacc gctgcaatct tggaagcaga   3300

gggagaaagg tgtttgagct tgtgggtgag ccctccatat actgcaccag caatgacgat   3360

caagtgggca tctggagcgg ccccgcccct cagtgcatta tacctaacaa atgcacgcct   3420

ccaaatgtgg aaaatggaat attggtatct gacaacagaa gcttattttc cttaaatgaa   3480

gttgtggagt ttaggtgtca gcctggcttt gtcatgaaag gaccccgccg tgtgaagtgc   3540

caggccctga acaaatggga gccagagtta ccaagctgct ccagggtgtg tcagccgcct   3600

ccagaaatcc tgcatggtga gcatacccca agccatcagg acaacttttc acctgggcag   3660

gaagtgttct acagctgtga gcctggctat gacctcagag gggctgcgtc tctgcactgc   3720

acaccccagg gagactggag ccctgaagcc ccgagatgtg cagtgaaatc ctgtgatgac   3780

ttcttgggtc aactccctca tggccgtgtg ctatttccac ttaatctcca gcttggggca   3840

aaggtgtcct ttgtctgtga tgaagggttt cgcttaaagg gcagttccgt tagtcattgt   3900

gtcttggttg gaatgagaag cctttggaat aacagtgttc ctgtgtgtga acatatcttt   3960

tgtccaaatc ctccagctat ccttaatggg agacacacag gaactccctc tggagatatt   4020

ccctatggaa aagaaatatc ttacacatgt gacccccacc cagacagagg gatgaccttc   4080

aacctcattg gggagagcac catccgctgc acaagtgacc ctcatgggaa tggggtttgg   4140

agcagccctg cccctcgctg tgaactttct gttcgtgctg gtcactgtaa aaccccagag   4200

cagtttccat ttgccagtcc tacgatccca attaatgact ttgagtttcc agtcgggaca   4260

tctttgaatt atgaatgccg tcctgggtat tttgggaaaa tgttctctat ctcctgccta   4320

gaaaacttgg tctggtcaag tgttgaagac aactgtagac gaaaatcatg tggacctcca   4380

ccagaaccct tcaatggaat ggtgcatata aacacagata cacagtttgg atcaacagtt   4440

aattattctt gtaatgaagg gtttcgactc attggttccc catctactac ttgtctcgtc   4500

tcaggcaata atgtcacatg ggataagaag gcacctattt gtgagatcat atcttgtgag   4560

ccacctccaa ccatatccaa tggagacttc tacagcaaca atagaacatc ttttcacaat   4620

ggaacggtgg taacttacca gtgccacact ggaccagatg gagaacagct gtttgagctt   4680

gtgggagaac ggtcaatata ttgcaccagc aaagatgatc aagttggtgt ttggagcagc   4740

cctccccctc ggtgtatttc tactaataaa tgcacagctc cagaagttga aaatgcaatt   4800

agagtaccag gaaacaggag tttcttttcc ctcactgaga tcgtcagatt tagatgtcag   4860

cccgggtttg tcatggtagg gtcccacact gtgcagtgcc agaccaatgg cagatggggg   4920

cccaagctgc cacactgctc cagggtgtgt cagccgcctc cagaaatcct gcatggtgag   4980

cataccctaa gccatcagga caacttttca cctgggcagg aagtgttcta cagctgtgag   5040

cccagctatg acctcagagg ggctgcgtct ctgcactgca cgccccaggg agactggagc   5100

cctgaagccc ctagatgtac agtgaaatcc tgtgatgact tcctgggcca actccctcat   5160

ggccgtgtgc tacttccact taatctccag cttggggcaa aggtgtcctt tgtttgcgat   5220

gaagggttcc gattaaaagg caggtctgct agtcattgtg tcttggctgg aatgaaagcc   5280

ctttggaata gcagtgttcc agtgtgtgaa caaatctttt gtccaaatcc tccagctatc   5340

cttaatggga gacacacagg aactcccttt ggagatattc cctatggaaa agaaatatct   5400

tacgcatgcg acacccaccc agacagaggg atgaccttca acctcattgg ggagagctcc   5460

atccgctgca caagtgaccg tcaagggaat ggggtttgga gcagccctgc ccctcgctgt   5520

gaactttctg ttcctgctgc ctgcccagat ccacccaaga tccaaaacgg gcattacatt   5580

ggaggacacg tatctctata tcttcctggg atgacaatca gctacatttg tgaccccggc   5640

tacctgttag tgggaaaggg cttcattttc tgtacagacc agggaatctg gagccaattg   5700

gatcattatt gcaaagaagt aaattgtagc ttcccactgt ttatgaatgg aatctcgaag   5760

gagttagaaa tgaaaaaagt atatcactat ggagattatg tgactttgaa gtgtgaagat   5820

gggtatactc tggaaggcag tccctggagc cagtgccagg cggatgacag atgggaccct   5880

cctctggcca aatgtacctc tcgtgcacat gatgctctca tagttggcac tttatctggt   5940

acgatcttct ttattttact catcattttc ctctcttgga taattctaaa gcacagaaaa   6000

ggcaataatg cacatgaaaa ccctaaagaa gtggctatcc atttacattc tcaaggaggc   6060

agcagcgttc atccccgaac tctgcaaaca aatgaagaaa atagcagggt ccttccttga   6120


<210>  25
<211>  483
<212>  PRT
<213>  Mus musculus

<400>  25

Met Glu Val Ser Ser Arg Ser Ser Glu Pro Leu Asp Pro Val Trp Leu 
1               5                   10                  15      


Leu Val Ala Phe Gly Arg Gly Gly Val Lys Leu Glu Val Leu Leu Leu 
            20                  25                  30          


Phe Leu Leu Pro Phe Thr Leu Gly Glu Leu Arg Gly Gly Leu Gly Lys 
        35                  40                  45              


His Gly His Thr Val His Arg Glu Pro Ala Val Asn Arg Leu Cys Ala 
    50                  55                  60                  


Asp Ser Lys Arg Trp Ser Gly Leu Pro Val Ser Ala Gln Arg Pro Phe 
65                  70                  75                  80  


Pro Met Gly His Cys Pro Ala Pro Ser Gln Leu Pro Ser Ala Lys Pro 
                85                  90                  95      


Ile Asn Leu Thr Asp Glu Ser Met Phe Pro Ile Gly Thr Tyr Leu Leu 
            100                 105                 110         


Tyr Glu Cys Leu Pro Gly Tyr Ile Lys Arg Gln Phe Ser Ile Thr Cys 
        115                 120                 125             


Lys Gln Asp Ser Thr Trp Thr Ser Ala Glu Asp Lys Cys Ile Arg Lys 
    130                 135                 140                 


Gln Cys Lys Thr Pro Ser Asp Pro Glu Asn Gly Leu Val His Val His 
145                 150                 155                 160 


Thr Gly Ile Gln Phe Gly Ser Arg Ile Asn Tyr Thr Cys Asn Gln Gly 
                165                 170                 175     


Tyr Arg Leu Ile Gly Ser Ser Ser Ala Val Cys Val Ile Thr Asp Gln 
            180                 185                 190         


Ser Val Asp Trp Asp Thr Glu Ala Pro Ile Cys Glu Trp Ile Pro Cys 
        195                 200                 205             


Glu Ile Pro Pro Gly Ile Pro Asn Gly Asp Phe Phe Ser Ser Thr Arg 
    210                 215                 220                 


Glu Asp Phe His Tyr Gly Met Val Val Thr Tyr Arg Cys Asn Thr Asp 
225                 230                 235                 240 


Ala Arg Gly Lys Ala Leu Phe Asn Leu Val Gly Glu Pro Ser Leu Tyr 
                245                 250                 255     


Cys Thr Ser Asn Asp Gly Glu Ile Gly Val Trp Ser Gly Pro Pro Pro 
            260                 265                 270         


Gln Cys Ile Glu Leu Asn Lys Cys Thr Pro Pro Pro Tyr Val Glu Asn 
        275                 280                 285             


Ala Val Met Leu Ser Glu Asn Arg Ser Leu Phe Ser Leu Arg Asp Ile 
    290                 295                 300                 


Val Glu Phe Arg Cys His Pro Gly Phe Ile Met Lys Gly Ala Ser Ser 
305                 310                 315                 320 


Val His Cys Gln Ser Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser Cys 
                325                 330                 335     


Phe Lys Gly Val Ile Cys Arg Leu Pro Gln Glu Met Ser Gly Phe Gln 
            340                 345                 350         


Lys Gly Leu Gly Met Lys Lys Glu Tyr Tyr Tyr Gly Glu Asn Val Thr 
        355                 360                 365             


Leu Glu Cys Glu Asp Gly Tyr Thr Leu Glu Gly Ser Ser Gln Ser Gln 
    370                 375                 380                 


Cys Gln Ser Asp Gly Ser Trp Asn Pro Leu Leu Ala Lys Cys Val Ser 
385                 390                 395                 400 


Arg Ser Ile Ser Gly Leu Ile Val Gly Ile Phe Ile Gly Ile Ile Val 
                405                 410                 415     


Phe Ile Leu Val Ile Ile Val Phe Ile Trp Met Ile Leu Lys Tyr Lys 
            420                 425                 430         


Lys Arg Asn Thr Thr Asp Glu Lys Tyr Lys Glu Val Gly Ile His Leu 
        435                 440                 445             


Asn Tyr Lys Glu Asp Ser Cys Val Arg Leu Gln Ser Leu Leu Thr Ser 
    450                 455                 460                 


Gln Glu Asn Ser Ser Thr Thr Ser Pro Ala Arg Asn Ser Leu Thr Gln 
465                 470                 475                 480 


Glu Val Ser 
            


<210>  26
<211>  1323
<212>  DNA
<213>  Mus musculus

<400>  26
atggaggtct cttctcggag ttcagagcct ctggatccgg tgtggctcct tgtagccttc     60

ggccggggag gagtcaagct agaagttttg ctgctgttct tgctgccatt tactttgggt    120

cactgcccag ccccatcaca gcttccttct gccaaaccta taaatctaac tgatgaatcc    180

atgtttccca ttggaacata tttgttgtat gaatgtctcc caggatatat caagaggcag    240

ttctctatca cctgcaaaca agactcaacc tggacgagtg ctgaagataa gtgtatacga    300

aaacaatgta aaactccttc agatcctgag aatggcttgg tacatgtaca cacaggcatt    360

cagtttggat cccgtattaa ttatacttgt aatcaaggat accgcctcat tggttcctcc    420

tctgctgtat gtgtcatcac tgatcaaagt gttgattggg atactgaggc acctatttgt    480

gagtggattc cttgtgagat acccccaggc attcccaatg gagatttctt cagttcaacc    540

agagaagact ttcattatgg aatggtggtt acctaccgct gcaacactga tgcgagaggg    600

aaggcgctct ttaacctggt gggtgagccc tccttatact gtaccagcaa cgatggtgaa    660

attggagtct ggagcggccc tcctcctcag tgcattgaac tcaacaaatg tactcctcct    720

ccctatgttg aaaatgcagt catgctgtct gagaacagaa gcttgttttc cttaagggat    780

attgtggagt ttagatgtca ccctggcttt atcatgaaag gagccagcag tgtgcattgt    840

cagtccctaa acaaatggga gccagagtta ccaagctgct tcaagggagt gatatgtcgt    900

ctccctcagg agatgagtgg attccagaag gggttgggaa tgaaaaaaga atattattat    960

ggagagaatg taaccttgga atgtgaggat gggtatactc tagaaggcag ttctcaaagc   1020

cagtgccagt ctgatggcag ctggaatcct cttctggcca aatgtgtatc tcgctcaatc   1080

agtggtctaa ttgttggaat tttcattggg ataatcgtct ttattttagt catcattgtt   1140

ttcatttgga tgattctgaa gtataaaaaa cgcaatacca cagatgaaaa gtataaagaa   1200

gtgggtattc atttaaatta taaagaagac agctgtgtcc gccttcagtc tctgctcaca   1260

agtcaggaga acagcagtac cactagccca gcacggaatt cactcactca agaagtctcc   1320

taa                                                                 1323


<210>  27
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial sequence

<400>  27
tctccagcat gtcataag                                                   18


<210>  28
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial sequence

<400>  28
gtctgccctt tgcaag                                                     16


<210>  29
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Artificial sequence

<400>  29
caatgtcctg cctctg                                                     16


<210>  30
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  30

Val Ser Val Phe Pro Leu Glu 
1               5           


