                         SEQUENCE LISTING

<110>  GlobeImmune, Inc.
       Apelian, David
       Franzusoff, Alex
       Duke, Richard
 
<120>  IMMUNOTHERAPY FOR CHRONIC HEPATITIS C VIRUS INFECTION

<130>  3923-20-PCT

<150>  61098306
<151>  2008-09-19

<150>  61110003
<151>  2008-10-31

<150>  61171373
<151>  2009-04-21

<150>  61231901
<151>  2009-08-06

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  1233
<212>  DNA
<213>  Artificial

<220>
<223>  recombinant fusion protein construct

<400>  1
atggccgacg aggcaccaca aggttcccgc tcattgacac cctgtacctg cggctcctcg       60

gacctttacc tggtcacgag gcacgccgat gtcattcccg tgcgccggcg aggtgatagc      120

aggggtagcc tgctttcgcc ccggcccatt tcctacttga aaggctcctc ggggggtccg      180

ctgttgtgcc ccgcgggaca cgccgtgggc ctattcaggg ccgcggtgtg cacccgtgga      240

gtggctaaag cggtggactt tatccctgtg gagaacctag ggacaaccat gagatccccg      300

gtgttcacgg acaactcctc tccaccagca gtgccccaga gcttccaggt ggcccacctg      360

catgctccca ccggcagcgg taagagcacc aaggtcccgg ctgcgtacgc agcccagggc      420

tacaaggtgt tggtgctcaa cccctctgtt gctgcaacgc tgggctttgg tgcttacatg      480

tccaaggccc atggggttga tcctaatatc aggaccgggg tgagaacaat taccactggc      540

agccccatca cgtactccac ctacggcaag ttccttgccg acggcgggtg ctcaggaggt      600

gcttatgaca taataatttg tgacgagtgc cactccacgg atgccacatc catcttgggc      660

atcggcactg tccttgacca agcagagact gcgggggcga gactggttgt gctcgccact      720

gctacccctc cgggctccgt cactgtgtcc catcctaaca tcgaggaggt tgctctgtcc      780

accaccggag agatcccctt ttacactagt acgaatccta aacctcaaag aaaaaccaaa      840

cgtaacacca accgtcgccc acaggacgtc aagttcccgg gtggcggtca gatcgttggt      900

ggagtttact tgttgccgcg caggggccct agattgggtg tgcgcgcgac gaggaagact      960

tccgagcggt cgcaacctcg aggtagacgt cagcctatcc ccaaggcacg tcggcccgag     1020

ggcaggacct gggctcagcc cgggtaccct tggcccctct atggcaatga gggttgcggg     1080

tgggcgggat ggctcctgtc tccccgtggc tctcggccta gctggggccc cacagacccc     1140

cggcgtaggt cgcgcaattt gggtaaggtc atcgataccc ttacgtgcgg cttcgccgac     1200

ctcatggggt acataccgct cgtcgaggac tag                                  1233


<210>  2
<211>  410
<212>  PRT
<213>  Artificial

<220>
<223>  recombinant fusion protein

<400>  2

Met Ala Asp Glu Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys Thr 
1               5                   10                  15      


Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val Ile 
            20                  25                  30          


Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg 
        35                  40                  45              


Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu Leu Cys Pro 
    50                  55                  60                  


Ala Gly His Ala Val Gly Leu Phe Arg Ala Ala Val Cys Thr Arg Gly 
65                  70                  75                  80  


Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Asn Leu Gly Thr Thr 
                85                  90                  95      


Met Arg Ser Pro Val Phe Thr Asp Asn Ser Ser Pro Pro Ala Val Pro 
            100                 105                 110         


Gln Ser Phe Gln Val Ala His Leu His Ala Pro Thr Gly Ser Gly Lys 
        115                 120                 125             


Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr Lys Val Leu 
    130                 135                 140                 


Val Leu Asn Pro Ser Val Ala Ala Thr Leu Gly Phe Gly Ala Tyr Met 
145                 150                 155                 160 


Ser Lys Ala His Gly Val Asp Pro Asn Ile Arg Thr Gly Val Arg Thr 
                165                 170                 175     


Ile Thr Thr Gly Ser Pro Ile Thr Tyr Ser Thr Tyr Gly Lys Phe Leu 
            180                 185                 190         


Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile Ile Cys Asp 
        195                 200                 205             


Glu Cys His Ser Thr Asp Ala Thr Ser Ile Leu Gly Ile Gly Thr Val 
    210                 215                 220                 


Leu Asp Gln Ala Glu Thr Ala Gly Ala Arg Leu Val Val Leu Ala Thr 
225                 230                 235                 240 


Ala Thr Pro Pro Gly Ser Val Thr Val Ser His Pro Asn Ile Glu Glu 
                245                 250                 255     


Val Ala Leu Ser Thr Thr Gly Glu Ile Pro Phe Tyr Thr Ser Thr Asn 
            260                 265                 270         


Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn Arg Arg Pro Gln 
        275                 280                 285             


Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly Gly Val Tyr Leu 
    290                 295                 300                 


Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala Thr Arg Lys Thr 
305                 310                 315                 320 


Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro Ile Pro Lys Ala 
                325                 330                 335     


Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly Tyr Pro Trp Pro 
            340                 345                 350         


Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp Leu Leu Ser Pro 
        355                 360                 365             


Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro Arg Arg Arg Ser 
    370                 375                 380                 


Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys Gly Phe Ala Asp 
385                 390                 395                 400 


Leu Met Gly Tyr Ile Pro Leu Val Glu Asp 
                405                 410 


<210>  3
<211>  1914
<212>  DNA
<213>  Artificial

<220>
<223>  recombinant fusion protein construct

<400>  3
atggccgacg aggcaccagc gcccatcacg gcgtacgccc agcagacgag aggcctccta       60

gggtgtataa tcaccagcct gactggccgg gacaaaaacc aagtggaggg tgaggtccag      120

atcgtgtcaa ctgctaccca aaccttcctg gcaacgtgca tcaatggggt atgctggact      180

gtctaccacg gggccggaac gaggaccatc gcatcaccca agggtcctgt catccagatg      240

tataccaatg tggaccaaga ccttgtgggc tggcccgctc ctcaaggttc ccgctcattg      300

acaccctgta cctgcggctc ctcggacctt tacctggtca cgaggcacgc cgatgtcatt      360

cccgtgcgcc ggcgaggtga tagcaggggt agcctgcttt cgccccggcc catttcctac      420

ttgaaaggct ccgctggggg tccgctgttg tgccccgcgg gacacgccgt gggcctattc      480

agggccgcgg tgtgcacccg tggagtggct aaagcggtgg actttatccc tgtggagaac      540

ctagggacaa ccatgagatc cccggtgttc acggacaact cctctccacc agcagtgccc      600

cagagcttcc aggtggccca cctgcatgct cccaccggca gcggtaagag caccaaggtc      660

ccggctgcgt acgcagccca gggctacaag gtgttggtgc tcaacccctc tgttgctgca      720

acgctgggct ttggtgctta catgtccaag gcccatgggg ttgatcctaa tatcaggacc      780

ggggtgagaa caattaccac tggcagcccc atcacgtact ccacctacgg caagttcctt      840

gccgacggcg ggtgctcagg aggtgcttat gacataataa tttgtgacga gtgccactcc      900

acggatgcca catccatctt gggcatcggc actgtccttg accaagcaga gactgcgggg      960

gcgagactgg ttgtgctcgc cactgctacc cctccgggct ccgtcactgt gtcccatcct     1020

aacatcgagg aggttgctct gtccaccacc ggagagatcc ccttttacgg caaggctatc     1080

cccctcgagg tgatcaaggg gggaagacat ctcatcttct gccactcaaa gaagaagtgc     1140

gacgagctcg ccgcgaagct ggtcgcattg ggcatcaatg ccgtggccta ctaccgcggt     1200

cttgacgtgt ctgtcatccc gaccagcggc gatgttgtcg tcgtgtcgac cgatgctctc     1260

atgactggct ttaccggcga cttcgactct gtgatagact gcaacacgtg tgtcactcag     1320

acagtcgatt tcagccttga ccctaccttt accattgaga caaccacgct cccccaggat     1380

gctgtctcca ggactcaacg ccggggcagg actggcaggg ggaagccagg catctataga     1440

tttgtggcac cgggggagcg cccctccggc atgttcgact cgtccgtcct ctgtgagtgc     1500

tatgacgcgg gctgtgcttg gtatgagctc acgcccgccg agactacagt taggctacga     1560

gcgtacatga acaccccggg gcttcccgtg tgccaggacc atcttgaatt ttgggagggc     1620

gtctttacgg gcctcactca tatagatgcc cactttttat cccagacaaa gcagagtggg     1680

gagaactttc cttacctggt agcgtaccaa gccaccgtgt gcgctagggc tcaagcccct     1740

cccccatcgt gggaccagat gtggaagtgt ttgatccgcc ttaaacccac cctccatggg     1800

ccaacacccc tgctatacag actgggcgct gttcagaatg aagtcaccct gacgcaccca     1860

atcaccaaat acatcatgac atgcatgtcg gccgacctgg aggtcgtcac gtag           1914


<210>  4
<211>  637
<212>  PRT
<213>  Artificial

<220>
<223>  recombinant fusion protein

<400>  4

Met Ala Asp Glu Ala Pro Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr 
1               5                   10                  15      


Arg Gly Leu Leu Gly Cys Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys 
            20                  25                  30          


Asn Gln Val Glu Gly Glu Val Gln Ile Val Ser Thr Ala Thr Gln Thr 
        35                  40                  45              


Phe Leu Ala Thr Cys Ile Asn Gly Val Cys Trp Thr Val Tyr His Gly 
    50                  55                  60                  


Ala Gly Thr Arg Thr Ile Ala Ser Pro Lys Gly Pro Val Ile Gln Met 
65                  70                  75                  80  


Tyr Thr Asn Val Asp Gln Asp Leu Val Gly Trp Pro Ala Pro Gln Gly 
                85                  90                  95      


Ser Arg Ser Leu Thr Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu 
            100                 105                 110         


Val Thr Arg His Ala Asp Val Ile Pro Val Arg Arg Arg Gly Asp Ser 
        115                 120                 125             


Arg Gly Ser Leu Leu Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser 
    130                 135                 140                 


Ala Gly Gly Pro Leu Leu Cys Pro Ala Gly His Ala Val Gly Leu Phe 
145                 150                 155                 160 


Arg Ala Ala Val Cys Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile 
                165                 170                 175     


Pro Val Glu Asn Leu Gly Thr Thr Met Arg Ser Pro Val Phe Thr Asp 
            180                 185                 190         


Asn Ser Ser Pro Pro Ala Val Pro Gln Ser Phe Gln Val Ala His Leu 
        195                 200                 205             


His Ala Pro Thr Gly Ser Gly Lys Ser Thr Lys Val Pro Ala Ala Tyr 
    210                 215                 220                 


Ala Ala Gln Gly Tyr Lys Val Leu Val Leu Asn Pro Ser Val Ala Ala 
225                 230                 235                 240 


Thr Leu Gly Phe Gly Ala Tyr Met Ser Lys Ala His Gly Val Asp Pro 
                245                 250                 255     


Asn Ile Arg Thr Gly Val Arg Thr Ile Thr Thr Gly Ser Pro Ile Thr 
            260                 265                 270         


Tyr Ser Thr Tyr Gly Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly 
        275                 280                 285             


Ala Tyr Asp Ile Ile Ile Cys Asp Glu Cys His Ser Thr Asp Ala Thr 
    290                 295                 300                 


Ser Ile Leu Gly Ile Gly Thr Val Leu Asp Gln Ala Glu Thr Ala Gly 
305                 310                 315                 320 


Ala Arg Leu Val Val Leu Ala Thr Ala Thr Pro Pro Gly Ser Val Thr 
                325                 330                 335     


Val Ser His Pro Asn Ile Glu Glu Val Ala Leu Ser Thr Thr Gly Glu 
            340                 345                 350         


Ile Pro Phe Tyr Gly Lys Ala Ile Pro Leu Glu Val Ile Lys Gly Gly 
        355                 360                 365             


Arg His Leu Ile Phe Cys His Ser Lys Lys Lys Cys Asp Glu Leu Ala 
    370                 375                 380                 


Ala Lys Leu Val Ala Leu Gly Ile Asn Ala Val Ala Tyr Tyr Arg Gly 
385                 390                 395                 400 


Leu Asp Val Ser Val Ile Pro Thr Ser Gly Asp Val Val Val Val Ser 
                405                 410                 415     


Thr Asp Ala Leu Met Thr Gly Phe Thr Gly Asp Phe Asp Ser Val Ile 
            420                 425                 430         


Asp Cys Asn Thr Cys Val Thr Gln Thr Val Asp Phe Ser Leu Asp Pro 
        435                 440                 445             


Thr Phe Thr Ile Glu Thr Thr Thr Leu Pro Gln Asp Ala Val Ser Arg 
    450                 455                 460                 


Thr Gln Arg Arg Gly Arg Thr Gly Arg Gly Lys Pro Gly Ile Tyr Arg 
465                 470                 475                 480 


Phe Val Ala Pro Gly Glu Arg Pro Ser Gly Met Phe Asp Ser Ser Val 
                485                 490                 495     


Leu Cys Glu Cys Tyr Asp Ala Gly Cys Ala Trp Tyr Glu Leu Thr Pro 
            500                 505                 510         


Ala Glu Thr Thr Val Arg Leu Arg Ala Tyr Met Asn Thr Pro Gly Leu 
        515                 520                 525             


Pro Val Cys Gln Asp His Leu Glu Phe Trp Glu Gly Val Phe Thr Gly 
    530                 535                 540                 


Leu Thr His Ile Asp Ala His Phe Leu Ser Gln Thr Lys Gln Ser Gly 
545                 550                 555                 560 


Glu Asn Phe Pro Tyr Leu Val Ala Tyr Gln Ala Thr Val Cys Ala Arg 
                565                 570                 575     


Ala Gln Ala Pro Pro Pro Ser Trp Asp Gln Met Trp Lys Cys Leu Ile 
            580                 585                 590         


Arg Leu Lys Pro Thr Leu His Gly Pro Thr Pro Leu Leu Tyr Arg Leu 
        595                 600                 605             


Gly Ala Val Gln Asn Glu Val Thr Leu Thr His Pro Ile Thr Lys Tyr 
    610                 615                 620                 


Ile Met Thr Cys Met Ser Ala Asp Leu Glu Val Val Thr 
625                 630                 635         


<210>  5
<211>  1491
<212>  DNA
<213>  Artificial

<220>
<223>  recombinant fusion protein construct

<400>  5
atggccgacg aggcaccata ccaagtgcgc aattcctcgg ggctttacca tgtcaccaat       60

gattgcccta actcgagtat tgtgtacgag gcggccgatg ccatcctgca cactccgggg      120

tgtgtccctt gcgttcgcga gggtaacgcc tcgaggtgtt gggtggcggt gacccccacg      180

gtggccacca gggacggcaa actccccaca acgcagcttc gacgtcatat cgatctgctt      240

gtcgggagcg ccaccctctg ctcggccctc tacgtggggg acctgtgcgg gtctgtcttt      300

cttgttggtc aactgtttac cttctctccc aggcgccact ggacgacgca agactgcaat      360

tgttctatct atcccggcca tataacgggt catcgcatgg catgggatat gatgatgaac      420

tggtccccta cggcagcgtt ggtggtagct cagctgctcc ggatcccaca agccatcatg      480

gacatggaaa cccacgtcac cgggggaagt gccggccgca ccacggctgg gcttgttggt      540

ctccttacac caggcgccaa gcagaacatc caactgatca acaccaacgg cagttggcac      600

atcaatagca cggccttgaa ctgcaatgaa agccttaaca ccggctggtt agcagggctc      660

ttctatcagc acaaattcaa ctcttcaggc tgtcctgaga ggttggccag ctgccgacgc      720

cttaccgatt ttgcccaggg ctggggtcct atcagttatg ccaacggaag cggcctcgac      780

gaacgcccct actgctggca ctaccctcca agaccttgtg gcattgtgcc cgcaaagagc      840

gtgtgtggcc cggtatattg cttcactccc agccccgtgg tggtgggaac gaccgacagg      900

tcgggcgcgc ctacctacag ctggggtgca aatgatacgg atgtcttcgt ccttaacaac      960

accaggccac cgctgggcaa ttggttcggt tgtacctgga tgaactcaac tggattcacc     1020

aaagtgtgcg gagcgccccc ttgtgtcatc ggaggggtgg gcaacaacac cttgctctgc     1080

cccactgatt gtttccgcaa gcatccggaa gccacatact ctcggtgcgg ctccggtccc     1140

tggattacac ccaggtgcat ggtcgactac ccgtataggc tttggcacta tccttgtacc     1200

atcaattaca ccatattcaa agtcaggatg tacgtgggag gggtcgagca caggctggaa     1260

gcggcctgca actggacgcg gggcgaacgc tgtgatctgg aagacaggga caggtccgag     1320

ctcagcccat tgctgctgtc caccacacag tggcaggtcc ttccgtgttc tttcacgacc     1380

ctgccagcct tgtccaccgg cctcatccac ctccaccaga acattgtgga cgtgcagtac     1440

ttgtacgggg tagggtcaag catcgcgtcc tgggccatta agtgggagta g              1491


<210>  6
<211>  496
<212>  PRT
<213>  Artificial

<220>
<223>  recombinant fusion protein

<400>  6

Met Ala Asp Glu Ala Pro Tyr Gln Val Arg Asn Ser Ser Gly Leu Tyr 
1               5                   10                  15      


His Val Thr Asn Asp Cys Pro Asn Ser Ser Ile Val Tyr Glu Ala Ala 
            20                  25                  30          


Asp Ala Ile Leu His Thr Pro Gly Cys Val Pro Cys Val Arg Glu Gly 
        35                  40                  45              


Asn Ala Ser Arg Cys Trp Val Ala Val Thr Pro Thr Val Ala Thr Arg 
    50                  55                  60                  


Asp Gly Lys Leu Pro Thr Thr Gln Leu Arg Arg His Ile Asp Leu Leu 
65                  70                  75                  80  


Val Gly Ser Ala Thr Leu Cys Ser Ala Leu Tyr Val Gly Asp Leu Cys 
                85                  90                  95      


Gly Ser Val Phe Leu Val Gly Gln Leu Phe Thr Phe Ser Pro Arg Arg 
            100                 105                 110         


His Trp Thr Thr Gln Asp Cys Asn Cys Ser Ile Tyr Pro Gly His Ile 
        115                 120                 125             


Thr Gly His Arg Met Ala Trp Asp Met Met Met Asn Trp Ser Pro Thr 
    130                 135                 140                 


Ala Ala Leu Val Val Ala Gln Leu Leu Arg Ile Pro Gln Ala Ile Met 
145                 150                 155                 160 


Asp Met Glu Thr His Val Thr Gly Gly Ser Ala Gly Arg Thr Thr Ala 
                165                 170                 175     


Gly Leu Val Gly Leu Leu Thr Pro Gly Ala Lys Gln Asn Ile Gln Leu 
            180                 185                 190         


Ile Asn Thr Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys 
        195                 200                 205             


Asn Glu Ser Leu Asn Thr Gly Trp Leu Ala Gly Leu Phe Tyr Gln His 
    210                 215                 220                 


Lys Phe Asn Ser Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Arg Arg 
225                 230                 235                 240 


Leu Thr Asp Phe Ala Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly 
                245                 250                 255     


Ser Gly Leu Asp Glu Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro 
            260                 265                 270         


Cys Gly Ile Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe 
        275                 280                 285             


Thr Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro 
    290                 295                 300                 


Thr Tyr Ser Trp Gly Ala Asn Asp Thr Asp Val Phe Val Leu Asn Asn 
305                 310                 315                 320 


Thr Arg Pro Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser 
                325                 330                 335     


Thr Gly Phe Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly 
            340                 345                 350         


Val Gly Asn Asn Thr Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys His 
        355                 360                 365             


Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro 
    370                 375                 380                 


Arg Cys Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr 
385                 390                 395                 400 


Ile Asn Tyr Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu 
                405                 410                 415     


His Arg Leu Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp 
            420                 425                 430         


Leu Glu Asp Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr 
        435                 440                 445             


Thr Gln Trp Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu 
    450                 455                 460                 


Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr 
465                 470                 475                 480 


Leu Tyr Gly Val Gly Ser Ser Ile Ala Ser Trp Ala Ile Lys Trp Glu 
                485                 490                 495     


<210>  7
<211>  483
<212>  DNA
<213>  Artificial

<220>
<223>  recombinant fusion protein construct

<400>  7
atggccgacg aggcaccatc tcagcactta ccgtacatcg agcaagggat gatgctcgct       60

gagcagttca agcagaaggc cctcggcctc ctgcagaccg cgtcccgcca tgcagaggtt      120

atcacccctg ctgtccagac caactggcag aaactcgagg tcttctgggc gaagcacatg      180

tggaatttca tcagtgggat acaatacttg gcgggcctgt caactagtcc tggagccctt      240

gtagtcggtg tggtctgcgc agcaatactg cgccggcacg ttggcccggg cgagggggca      300

gtgcaatgga tgaaccggct aatagccttc gcctcccggg ggaaccatgt ttcccccacg      360

cactacgtgc cggagagcga tgcagccgcc cgcgtcactg ccatactcag cagcctcact      420

gtaacccagc tcctgaggcg actgcatcag tggataagct cggagtgtac cactccatgc      480

tag                                                                    483


<210>  8
<211>  160
<212>  PRT
<213>  Artificial

<220>
<223>  recombinant fusion protein

<400>  8

Met Ala Asp Glu Ala Pro Ser Gln His Leu Pro Tyr Ile Glu Gln Gly 
1               5                   10                  15      


Met Met Leu Ala Glu Gln Phe Lys Gln Lys Ala Leu Gly Leu Leu Gln 
            20                  25                  30          


Thr Ala Ser Arg His Ala Glu Val Ile Thr Pro Ala Val Gln Thr Asn 
        35                  40                  45              


Trp Gln Lys Leu Glu Val Phe Trp Ala Lys His Met Trp Asn Phe Ile 
    50                  55                  60                  


Ser Gly Ile Gln Tyr Leu Ala Gly Leu Ser Thr Ser Pro Gly Ala Leu 
65                  70                  75                  80  


Val Val Gly Val Val Cys Ala Ala Ile Leu Arg Arg His Val Gly Pro 
                85                  90                  95      


Gly Glu Gly Ala Val Gln Trp Met Asn Arg Leu Ile Ala Phe Ala Ser 
            100                 105                 110         


Arg Gly Asn His Val Ser Pro Thr His Tyr Val Pro Glu Ser Asp Ala 
        115                 120                 125             


Ala Ala Arg Val Thr Ala Ile Leu Ser Ser Leu Thr Val Thr Gln Leu 
    130                 135                 140                 


Leu Arg Arg Leu His Gln Trp Ile Ser Ser Glu Cys Thr Thr Pro Cys 
145                 150                 155                 160 


<210>  9
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  9

Met Ala Asp Glu Ala Pro 
1               5       


<210>  10
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic peptide

<400>  10

Gly Gly Gly His His His His His His 
1               5                   


<210>  11
<211>  2256
<212>  DNA
<213>  Artificial

<220>
<223>  recombinant fusion protein construct

<400>  11
atggccgacg aggcaccaag cacgaatcct aaacctcaaa gaaaaaccaa acgtaacacc       60

aaccgtcgcc cacaggacgt caagttcccg ggtggcggtc agatcgttgg tggagtttac      120

ttgttgccgc gcaggggccc tagattgggt gtgcgcgcga cgaggaagac ttccgagcgg      180

tcgcaacctc gaggtagacg tcagcctatc cccaaggcac gtcggcccga gggcaggacc      240

tgggctcagc ccgggtaccc ttggcccctc tatggcaatg agggttgcgg gtgggcggga      300

tggctcctgt ctccccgtgg ctctcggcct agctggggcc ccacagaccc ccggcgtagg      360

tcgcgcaatt tgggtaaggt catcgatacc cttacgtgcg gcttcgccga cctcatgggg      420

tacataccgc tcgtcggcgc ccctcttgga ggcgctgcca gggccctggc gcatggcgtc      480

cgggttctgg aagacggcgt gaactatgca acagggaacc ttcctggttg ctctttctct      540

atcttccttc tggccctgct ctcttgcctg actgtgcccg cttcagccta ccaagtgcgc      600

aattcctcgg ggctttacca tgtcaccaat gattgcccta actcgagtat tgtgtacgag      660

gcggccgatg ccatcctgca cactccgggg tgtgtccctt gcgttcgcga gggtaacgcc      720

tcgaggtgtt gggtggcggt gacccccacg gtggccacca gggacggcaa actccccaca      780

acgcagcttc gacgtcatat cgatctgctt gtcgggagcg ccaccctctg ctcggccctc      840

tacgtggggg acctgtgcgg gtctgtcttt cttgttggtc aactgtttac cttctctccc      900

aggcgccact ggacgacgca agactgcaat tgttctatct atcccggcca tataacgggt      960

catcgcatgg catgggatat gatgatgaac tggtccccta cggcagcgtt ggtggtagct     1020

cagctgctcc ggatcccaca agccatcatg gacatgatcg ctggtgctca ctggggagtc     1080

ctggcgggca tagcgtattt ctccatggtg gggaactggg cgaaggtcct ggtagtgctg     1140

ctgctatttg ccggcgtcga cgcggaaacc cacgtcaccg ggggaagtgc cggccgcacc     1200

acggctgggc ttgttggtct ccttacacca ggcgccaagc agaacatcca actgatcaac     1260

accaacggca gttggcacat caatagcacg gccttgaact gcaatgaaag ccttaacacc     1320

ggctggttag cagggctctt ctatcagcac aaattcaact cttcaggctg tcctgagagg     1380

ttggccagct gccgacgcct taccgatttt gcccagggct ggggtcctat cagttatgcc     1440

aacggaagcg gcctcgacga acgcccctac tgctggcact accctccaag accttgtggc     1500

attgtgcccg caaagagcgt gtgtggcccg gtatattgct tcactcccag ccccgtggtg     1560

gtgggaacga ccgacaggtc gggcgcgcct acctacagct ggggtgcaaa tgatacggat     1620

gtcttcgtcc ttaacaacac caggccaccg ctgggcaatt ggttcggttg tacctggatg     1680

aactcaactg gattcaccaa agtgtgcgga gcgccccctt gtgtcatcgg aggggtgggc     1740

aacaacacct tgctctgccc cactgattgt ttccgcaagc atccggaagc cacatactct     1800

cggtgcggct ccggtccctg gattacaccc aggtgcatgg tcgactaccc gtataggctt     1860

tggcactatc cttgtaccat caattacacc atattcaaag tcaggatgta cgtgggaggg     1920

gtcgagcaca ggctggaagc ggcctgcaac tggacgcggg gcgaacgctg tgatctggaa     1980

gacagggaca ggtccgagct cagcccattg ctgctgtcca ccacacagtg gcaggtcctt     2040

ccgtgttctt tcacgaccct gccagccttg tccaccggcc tcatccacct ccaccagaac     2100

attgtggacg tgcagtactt gtacggggta gggtcaagca tcgcgtcctg ggccattaag     2160

tgggagtacg tcgttctcct gttcctcctg cttgcagacg cgcgcgtctg ctcctgcttg     2220

tggatgatgt tactcatatc ccaagcggag gcgtag                               2256


<210>  12
<211>  751
<212>  PRT
<213>  Artificial

<220>
<223>  recombinant fusion protein

<400>  12

Met Ala Asp Glu Ala Pro Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr 
1               5                   10                  15      


Lys Arg Asn Thr Asn Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly 
            20                  25                  30          


Gly Gln Ile Val Gly Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg 
        35                  40                  45              


Leu Gly Val Arg Ala Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg 
    50                  55                  60                  


Gly Arg Arg Gln Pro Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr 
65                  70                  75                  80  


Trp Ala Gln Pro Gly Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys 
                85                  90                  95      


Gly Trp Ala Gly Trp Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp 
            100                 105                 110         


Gly Pro Thr Asp Pro Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile 
        115                 120                 125             


Asp Thr Leu Thr Cys Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu 
    130                 135                 140                 


Val Gly Ala Pro Leu Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val 
145                 150                 155                 160 


Arg Val Leu Glu Asp Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly 
                165                 170                 175     


Cys Ser Phe Ser Ile Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val 
            180                 185                 190         


Pro Ala Ser Ala Tyr Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val 
        195                 200                 205             


Thr Asn Asp Cys Pro Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Ala 
    210                 215                 220                 


Ile Leu His Thr Pro Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala 
225                 230                 235                 240 


Ser Arg Cys Trp Val Ala Val Thr Pro Thr Val Ala Thr Arg Asp Gly 
                245                 250                 255     


Lys Leu Pro Thr Thr Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly 
            260                 265                 270         


Ser Ala Thr Leu Cys Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser 
        275                 280                 285             


Val Phe Leu Val Gly Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp 
    290                 295                 300                 


Thr Thr Gln Asp Cys Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly 
305                 310                 315                 320 


His Arg Met Ala Trp Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala 
                325                 330                 335     


Leu Val Val Ala Gln Leu Leu Arg Ile Pro Gln Ala Ile Met Asp Met 
            340                 345                 350         


Ile Ala Gly Ala His Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser 
        355                 360                 365             


Met Val Gly Asn Trp Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala 
    370                 375                 380                 


Gly Val Asp Ala Glu Thr His Val Thr Gly Gly Ser Ala Gly Arg Thr 
385                 390                 395                 400 


Thr Ala Gly Leu Val Gly Leu Leu Thr Pro Gly Ala Lys Gln Asn Ile 
                405                 410                 415     


Gln Leu Ile Asn Thr Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu 
            420                 425                 430         


Asn Cys Asn Glu Ser Leu Asn Thr Gly Trp Leu Ala Gly Leu Phe Tyr 
        435                 440                 445             


Gln His Lys Phe Asn Ser Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys 
    450                 455                 460                 


Arg Arg Leu Thr Asp Phe Ala Gln Gly Trp Gly Pro Ile Ser Tyr Ala 
465                 470                 475                 480 


Asn Gly Ser Gly Leu Asp Glu Arg Pro Tyr Cys Trp His Tyr Pro Pro 
                485                 490                 495     


Arg Pro Cys Gly Ile Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr 
            500                 505                 510         


Cys Phe Thr Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly 
        515                 520                 525             


Ala Pro Thr Tyr Ser Trp Gly Ala Asn Asp Thr Asp Val Phe Val Leu 
    530                 535                 540                 


Asn Asn Thr Arg Pro Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met 
545                 550                 555                 560 


Asn Ser Thr Gly Phe Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile 
                565                 570                 575     


Gly Gly Val Gly Asn Asn Thr Leu Leu Cys Pro Thr Asp Cys Phe Arg 
            580                 585                 590         


Lys His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile 
        595                 600                 605             


Thr Pro Arg Cys Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro 
    610                 615                 620                 


Cys Thr Ile Asn Tyr Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly 
625                 630                 635                 640 


Val Glu His Arg Leu Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg 
                645                 650                 655     


Cys Asp Leu Glu Asp Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu 
            660                 665                 670         


Ser Thr Thr Gln Trp Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro 
        675                 680                 685             


Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val 
    690                 695                 700                 


Gln Tyr Leu Tyr Gly Val Gly Ser Ser Ile Ala Ser Trp Ala Ile Lys 
705                 710                 715                 720 


Trp Glu Tyr Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val 
                725                 730                 735     


Cys Ser Cys Leu Trp Met Met Leu Leu Ile Ser Gln Ala Glu Ala 
            740                 745                 750     


<210>  13
<211>  1908
<212>  DNA
<213>  Artificial

<220>
<223>  recombinant fusion protein construct

<400>  13
atggccgacg aggcaccaag tacgaatcct aaacctcaaa gaaaaaccaa acgtaacacc       60

aaccgtcgcc cacaggacgt caagttcccg ggtggcggtc agatcgttgg tggagtttac      120

ttgttgccgc gcaggggccc tagattgggt gtgcgcgcga cgaggaagac ttccgagcgg      180

tcgcaacctc gaggtagacg tcagcctatc cccaaggcac gtcggcccga gggcaggacc      240

tgggctcagc ccgggtaccc ttggcccctc tatggcaatg agggttgcgg gtgggcggga      300

tggctcctgt ctccccgtgg ctctcggcct agctggggcc ccacagaccc ccggcgtagg      360

tcgcgcaatt tgggtaaggt catcgatacc cttacgtgcg gcttcgccga cctcatgggg      420

tacataccgc tcgtctacca agtgcgcaat tcctcggggc tttaccatgt caccaatgat      480

tgccctaact cgagtattgt gtacgaggcg gccgatgcca tcctgcacac tccggggtgt      540

gtcccttgcg ttcgcgaggg taacgcctcg aggtgttggg tggcggtgac ccccacggtg      600

gccaccaggg acggcaaact ccccacaacg cagcttcgac gtcatatcga tctgcttgtc      660

gggagcgcca ccctctgctc ggccctctac gtgggggacc tgtgcgggtc tgtctttctt      720

gttggtcaac tgtttacctt ctctcccagg cgccactgga cgacgcaaga ctgcaattgt      780

tctatctatc ccggccatat aacgggtcat cgcatggcat gggatatgat gatgaactgg      840

tcccctacgg cagcgttggt ggtagctcag ctgctccgga tcccacaagc catcatggac      900

atggaaaccc acgtcaccgg gggaagtgcc ggccgcacca cggctgggct tgttggtctc      960

cttacaccag gcgccaagca gaacatccaa ctgatcaaca ccaacggcag ttggcacatc     1020

aatagcacgg ccttgaactg caatgaaagc cttaacaccg gctggttagc agggctcttc     1080

tatcagcaca aattcaactc ttcaggctgt cctgagaggt tggccagctg ccgacgcctt     1140

accgattttg cccagggctg gggtcctatc agttatgcca acggaagcgg cctcgacgaa     1200

cgcccctact gctggcacta ccctccaaga ccttgtggca ttgtgcccgc aaagagcgtg     1260

tgtggcccgg tatattgctt cactcccagc cccgtggtgg tgggaacgac cgacaggtcg     1320

ggcgcgccta cctacagctg gggtgcaaat gatacggatg tcttcgtcct taacaacacc     1380

aggccaccgc tgggcaattg gttcggttgt acctggatga actcaactgg attcaccaaa     1440

gtgtgcggag cgcccccttg tgtcatcgga ggggtgggca acaacacctt gctctgcccc     1500

actgattgtt tccgcaagca tccggaagcc acatactctc ggtgcggctc cggtccctgg     1560

attacaccca ggtgcatggt cgactacccg tataggcttt ggcactatcc ttgtaccatc     1620

aattacacca tattcaaagt caggatgtac gtgggagggg tcgagcacag gctggaagcg     1680

gcctgcaact ggacgcgggg cgaacgctgt gatctggaag acagggacag gtccgagctc     1740

agcccattgc tgctgtccac cacacagtgg caggtccttc cgtgttcttt cacgaccctg     1800

ccagccttgt ccaccggcct catccacctc caccagaaca ttgtggacgt gcagtacttg     1860

tacggggtag ggtcaagcat cgcgtcctgg gccattaagt gggagtag                  1908


<210>  14
<211>  635
<212>  PRT
<213>  Artificial

<220>
<223>  recombinant fusion protein

<400>  14

Met Ala Asp Glu Ala Pro Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr 
1               5                   10                  15      


Lys Arg Asn Thr Asn Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly 
            20                  25                  30          


Gly Gln Ile Val Gly Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg 
        35                  40                  45              


Leu Gly Val Arg Ala Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg 
    50                  55                  60                  


Gly Arg Arg Gln Pro Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr 
65                  70                  75                  80  


Trp Ala Gln Pro Gly Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys 
                85                  90                  95      


Gly Trp Ala Gly Trp Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp 
            100                 105                 110         


Gly Pro Thr Asp Pro Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile 
        115                 120                 125             


Asp Thr Leu Thr Cys Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu 
    130                 135                 140                 


Val Tyr Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp 
145                 150                 155                 160 


Cys Pro Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Ala Ile Leu His 
                165                 170                 175     


Thr Pro Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Arg Cys 
            180                 185                 190         


Trp Val Ala Val Thr Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro 
        195                 200                 205             


Thr Thr Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr 
    210                 215                 220                 


Leu Cys Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu 
225                 230                 235                 240 


Val Gly Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln 
                245                 250                 255     


Asp Cys Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met 
            260                 265                 270         


Ala Trp Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Val Val 
        275                 280                 285             


Ala Gln Leu Leu Arg Ile Pro Gln Ala Ile Met Asp Met Glu Thr His 
    290                 295                 300                 


Val Thr Gly Gly Ser Ala Gly Arg Thr Thr Ala Gly Leu Val Gly Leu 
305                 310                 315                 320 


Leu Thr Pro Gly Ala Lys Gln Asn Ile Gln Leu Ile Asn Thr Asn Gly 
                325                 330                 335     


Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Glu Ser Leu Asn 
            340                 345                 350         


Thr Gly Trp Leu Ala Gly Leu Phe Tyr Gln His Lys Phe Asn Ser Ser 
        355                 360                 365             


Gly Cys Pro Glu Arg Leu Ala Ser Cys Arg Arg Leu Thr Asp Phe Ala 
    370                 375                 380                 


Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Leu Asp Glu 
385                 390                 395                 400 


Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Gly Ile Val Pro 
                405                 410                 415     


Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser Pro Val 
            420                 425                 430         


Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Ser Trp Gly 
        435                 440                 445             


Ala Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro Pro Leu 
    450                 455                 460                 


Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe Thr Lys 
465                 470                 475                 480 


Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn Asn Thr 
                485                 490                 495     


Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala Thr Tyr 
            500                 505                 510         


Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Met Val Asp 
        515                 520                 525             


Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr Thr Ile 
    530                 535                 540                 


Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu Glu Ala 
545                 550                 555                 560 


Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp Arg Asp 
                565                 570                 575     


Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp Gln Val 
            580                 585                 590         


Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly Leu Ile 
        595                 600                 605             


His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly Val Gly 
    610                 615                 620                 


Ser Ser Ile Ala Ser Trp Ala Ile Lys Trp Glu 
625                 630                 635 


<210>  15
<211>  2538
<212>  DNA
<213>  Artificial

<220>
<223>  recombinant fusion protein construct

<400>  15
atggccgacg aggcaccagc gcccatcacg gcgtacgccc agcagacgag aggcctccta       60

gggtgtataa tcaccagcct gactggccgg gacaaaaacc aagtggaggg tgaggtccag      120

atcgtgtcaa ctgctaccca aaccttcctg gcaacgtgca tcaatggggt atgctggact      180

gtctaccacg gggccggaac gaggaccatc gcatcaccca agggtcctgt catccagatg      240

tataccaatg tggaccaaga ccttgtgggc tggcccgctc ctcaaggttc ccgctcattg      300

acaccctgta cctgcggctc ctcggacctt tacctggtca cgaggcacgc cgatgtcatt      360

cccgtgcgcc ggcgaggtga tagcaggggt agcctgcttt cgccccggcc catttcctac      420

ttgaaaggct ccgctggggg tccgctgttg tgccccgcgg gacacgccgt gggcctattc      480

agggccgcgg tgtgcacccg tggagtggct aaagcggtgg actttatccc tgtggagaac      540

ctagggacaa ccatgagatc cccggtgttc acggacaact cctctccacc agcagtgccc      600

cagagcttcc aggtggccca cctgcatgct cccaccggca gcggtaagag caccaaggtc      660

ccggctgcgt acgcagccca gggctacaag gtgttggtgc tcaacccctc tgttgctgca      720

acgctgggct ttggtgctta catgtccaag gcccatgggg ttgatcctaa tatcaggacc      780

ggggtgagaa caattaccac tggcagcccc atcacgtact ccacctacgg caagttcctt      840

gccgacggcg ggtgctcagg aggtgcttat gacataataa tttgtgacga gtgccactcc      900

acggatgcca catccatctt gggcatcggc actgtccttg accaagcaga gactgcgggg      960

gcgagactgg ttgtgctcgc cactgctacc cctccgggct ccgtcactgt gtcccatcct     1020

aacatcgagg aggttgctct gtccaccacc ggagagatcc ccttttacgg caaggctatc     1080

cccctcgagg tgatcaaggg gggaagacat ctcatcttct gccactcaaa gaagaagtgc     1140

gacgagctcg ccgcgaagct ggtcgcattg ggcatcaatg ccgtggccta ctaccgcggt     1200

cttgacgtgt ctgtcatccc gaccagcggc gatgttgtcg tcgtgtcgac cgatgctctc     1260

atgactggct ttaccggcga cttcgactct gtgatagact gcaacacgtg tgtcactcag     1320

acagtcgatt tcagccttga ccctaccttt accattgaga caaccacgct cccccaggat     1380

gctgtctcca ggactcaacg ccggggcagg actggcaggg ggaagccagg catctataga     1440

tttgtggcac cgggggagcg cccctccggc atgttcgact cgtccgtcct ctgtgagtgc     1500

tatgacgcgg gctgtgcttg gtatgagctc acgcccgccg agactacagt taggctacga     1560

gcgtacatga acaccccggg gcttcccgtg tgccaggacc atcttgaatt ttgggagggc     1620

gtctttacgg gcctcactca tatagatgcc cactttttat cccagacaaa gcagagtggg     1680

gagaactttc cttacctggt agcgtaccaa gccaccgtgt gcgctagggc tcaagcccct     1740

cccccatcgt gggaccagat gtggaagtgt ttgatccgcc ttaaacccac cctccatggg     1800

ccaacacccc tgctatacag actgggcgct gttcagaatg aagtcaccct gacgcaccca     1860

atcaccaaat acatcatgac atgcatgtcg gccgacctgg aggtcgtcac gagcacctgg     1920

gtgctcgttg gcggcgtcct ggctgctctg gccgcgtatt gcctgtcaac aggctgcgtg     1980

gtcatagtgg gcaggattgt cttgtccggg aagccggcaa ttatacctga cagggaggtt     2040

ctctaccagg agttcgatga gatggaagag tgctctcagc acttaccgta catcgagcaa     2100

gggatgatgc tcgctgagca gttcaagcag aaggccctcg gcctcctgca gaccgcgtcc     2160

cgccatgcag aggttatcac ccctgctgtc cagaccaact ggcagaaact cgaggtcttc     2220

tgggcgaagc acatgtggaa tttcatcagt gggatacaat acttggcggg cctgtcaact     2280

agtcctggag cccttgtagt cggtgtggtc tgcgcagcaa tactgcgccg gcacgttggc     2340

ccgggcgagg gggcagtgca atggatgaac cggctaatag ccttcgcctc ccgggggaac     2400

catgtttccc ccacgcacta cgtgccggag agcgatgcag ccgcccgcgt cactgccata     2460

ctcagcagcc tcactgtaac ccagctcctg aggcgactgc atcagtggat aagctcggag     2520

tgtaccactc catgctag                                                   2538


<210>  16
<211>  845
<212>  PRT
<213>  Artificial

<220>
<223>  recombinant fusion protein

<400>  16

Met Ala Asp Glu Ala Pro Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr 
1               5                   10                  15      


Arg Gly Leu Leu Gly Cys Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys 
            20                  25                  30          


Asn Gln Val Glu Gly Glu Val Gln Ile Val Ser Thr Ala Thr Gln Thr 
        35                  40                  45              


Phe Leu Ala Thr Cys Ile Asn Gly Val Cys Trp Thr Val Tyr His Gly 
    50                  55                  60                  


Ala Gly Thr Arg Thr Ile Ala Ser Pro Lys Gly Pro Val Ile Gln Met 
65                  70                  75                  80  


Tyr Thr Asn Val Asp Gln Asp Leu Val Gly Trp Pro Ala Pro Gln Gly 
                85                  90                  95      


Ser Arg Ser Leu Thr Pro Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu 
            100                 105                 110         


Val Thr Arg His Ala Asp Val Ile Pro Val Arg Arg Arg Gly Asp Ser 
        115                 120                 125             


Arg Gly Ser Leu Leu Ser Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser 
    130                 135                 140                 


Ala Gly Gly Pro Leu Leu Cys Pro Ala Gly His Ala Val Gly Leu Phe 
145                 150                 155                 160 


Arg Ala Ala Val Cys Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile 
                165                 170                 175     


Pro Val Glu Asn Leu Gly Thr Thr Met Arg Ser Pro Val Phe Thr Asp 
            180                 185                 190         


Asn Ser Ser Pro Pro Ala Val Pro Gln Ser Phe Gln Val Ala His Leu 
        195                 200                 205             


His Ala Pro Thr Gly Ser Gly Lys Ser Thr Lys Val Pro Ala Ala Tyr 
    210                 215                 220                 


Ala Ala Gln Gly Tyr Lys Val Leu Val Leu Asn Pro Ser Val Ala Ala 
225                 230                 235                 240 


Thr Leu Gly Phe Gly Ala Tyr Met Ser Lys Ala His Gly Val Asp Pro 
                245                 250                 255     


Asn Ile Arg Thr Gly Val Arg Thr Ile Thr Thr Gly Ser Pro Ile Thr 
            260                 265                 270         


Tyr Ser Thr Tyr Gly Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly 
        275                 280                 285             


Ala Tyr Asp Ile Ile Ile Cys Asp Glu Cys His Ser Thr Asp Ala Thr 
    290                 295                 300                 


Ser Ile Leu Gly Ile Gly Thr Val Leu Asp Gln Ala Glu Thr Ala Gly 
305                 310                 315                 320 


Ala Arg Leu Val Val Leu Ala Thr Ala Thr Pro Pro Gly Ser Val Thr 
                325                 330                 335     


Val Ser His Pro Asn Ile Glu Glu Val Ala Leu Ser Thr Thr Gly Glu 
            340                 345                 350         


Ile Pro Phe Tyr Gly Lys Ala Ile Pro Leu Glu Val Ile Lys Gly Gly 
        355                 360                 365             


Arg His Leu Ile Phe Cys His Ser Lys Lys Lys Cys Asp Glu Leu Ala 
    370                 375                 380                 


Ala Lys Leu Val Ala Leu Gly Ile Asn Ala Val Ala Tyr Tyr Arg Gly 
385                 390                 395                 400 


Leu Asp Val Ser Val Ile Pro Thr Ser Gly Asp Val Val Val Val Ser 
                405                 410                 415     


Thr Asp Ala Leu Met Thr Gly Phe Thr Gly Asp Phe Asp Ser Val Ile 
            420                 425                 430         


Asp Cys Asn Thr Cys Val Thr Gln Thr Val Asp Phe Ser Leu Asp Pro 
        435                 440                 445             


Thr Phe Thr Ile Glu Thr Thr Thr Leu Pro Gln Asp Ala Val Ser Arg 
    450                 455                 460                 


Thr Gln Arg Arg Gly Arg Thr Gly Arg Gly Lys Pro Gly Ile Tyr Arg 
465                 470                 475                 480 


Phe Val Ala Pro Gly Glu Arg Pro Ser Gly Met Phe Asp Ser Ser Val 
                485                 490                 495     


Leu Cys Glu Cys Tyr Asp Ala Gly Cys Ala Trp Tyr Glu Leu Thr Pro 
            500                 505                 510         


Ala Glu Thr Thr Val Arg Leu Arg Ala Tyr Met Asn Thr Pro Gly Leu 
        515                 520                 525             


Pro Val Cys Gln Asp His Leu Glu Phe Trp Glu Gly Val Phe Thr Gly 
    530                 535                 540                 


Leu Thr His Ile Asp Ala His Phe Leu Ser Gln Thr Lys Gln Ser Gly 
545                 550                 555                 560 


Glu Asn Phe Pro Tyr Leu Val Ala Tyr Gln Ala Thr Val Cys Ala Arg 
                565                 570                 575     


Ala Gln Ala Pro Pro Pro Ser Trp Asp Gln Met Trp Lys Cys Leu Ile 
            580                 585                 590         


Arg Leu Lys Pro Thr Leu His Gly Pro Thr Pro Leu Leu Tyr Arg Leu 
        595                 600                 605             


Gly Ala Val Gln Asn Glu Val Thr Leu Thr His Pro Ile Thr Lys Tyr 
    610                 615                 620                 


Ile Met Thr Cys Met Ser Ala Asp Leu Glu Val Val Thr Ser Thr Trp 
625                 630                 635                 640 


Val Leu Val Gly Gly Val Leu Ala Ala Leu Ala Ala Tyr Cys Leu Ser 
                645                 650                 655     


Thr Gly Cys Val Val Ile Val Gly Arg Ile Val Leu Ser Gly Lys Pro 
            660                 665                 670         


Ala Ile Ile Pro Asp Arg Glu Val Leu Tyr Gln Glu Phe Asp Glu Met 
        675                 680                 685             


Glu Glu Cys Ser Gln His Leu Pro Tyr Ile Glu Gln Gly Met Met Leu 
    690                 695                 700                 


Ala Glu Gln Phe Lys Gln Lys Ala Leu Gly Leu Leu Gln Thr Ala Ser 
705                 710                 715                 720 


Arg His Ala Glu Val Ile Thr Pro Ala Val Gln Thr Asn Trp Gln Lys 
                725                 730                 735     


Leu Glu Val Phe Trp Ala Lys His Met Trp Asn Phe Ile Ser Gly Ile 
            740                 745                 750         


Gln Tyr Leu Ala Gly Leu Ser Thr Ser Pro Gly Ala Leu Val Val Gly 
        755                 760                 765             


Val Val Cys Ala Ala Ile Leu Arg Arg His Val Gly Pro Gly Glu Gly 
    770                 775                 780                 


Ala Val Gln Trp Met Asn Arg Leu Ile Ala Phe Ala Ser Arg Gly Asn 
785                 790                 795                 800 


His Val Ser Pro Thr His Tyr Val Pro Glu Ser Asp Ala Ala Ala Arg 
                805                 810                 815     


Val Thr Ala Ile Leu Ser Ser Leu Thr Val Thr Gln Leu Leu Arg Arg 
            820                 825                 830         


Leu His Gln Trp Ile Ser Ser Glu Cys Thr Thr Pro Cys 
        835                 840                 845 


<210>  17
<211>  2982
<212>  DNA
<213>  Artificial

<220>
<223>  recombinant fusion protein construct

<400>  17
atggccgacg aggcaccatc cggttcctgg ctaagggaca tctgggactg gatatgcgag       60

gtgctgagcg actttaagac ctggctgaaa gccaagctca tgccacaact gcctgggatt      120

ccctttgtgt cctgccagcg cgggtatagg ggggtctggc gaggagacgg cattatgcac      180

actcgctgcc actgtggagc tgagatcact ggacatgtca aaaacgggac gatgaggatc      240

gtcggtccta ggacctgcag gaacatgtgg agtgggacgt tccccattaa cgcctacacc      300

acgggcccct gtactcccct tcctgcgccg aactataagt tcgcgctgtg gagggtgtct      360

gcagaggaat acgtggagat aaggcgggtg ggggacttcc actacgtatc gggtatgact      420

actgacaatc ttaaatgccc gtgccagatc ccatcgcccg aatttttcac agaattggac      480

ggggtgcgcc tacataggtt tgcgccccct tgcaagccct tgctgcggga ggaggtatca      540

ttcagagtag gactccacga gtacccggtg gggtcgcaat taccttgcga gcccgaaccg      600

gacgtagccg tgttgacgtc catgctcact gatccctccc atataacagc agaggcggcc      660

gggagaaggt tggcgagagg gtcaccccct tctatggcca gctcctcggc cagccagctg      720

tccgctccat ctctcaaggc aacttgcacc gccaaccatg actcccctga cgccgagctc      780

atagaggcta acctcctgtg gaggcaggag atgggcggca acatcaccag ggttgagtca      840

gagaacaaag tggtgattct ggactccttc gatccgcttg tggcagagga ggatgagcgg      900

gaggtctccg tacccgcaga aattctgcgg aagtctcgga gattcgcccg ggccctgccc      960

gtttgggcgc ggccggacta caaccccccg ctagtagaga cgtggaaaaa gcctgactac     1020

gaaccacctg tggtccatgg ctgcccgcta ccacctccac ggtcccctcc tgtgcctccg     1080

cctcggaaaa agcgtacggt ggtcctcacc gaatcaaccc tatctactgc cttggccgag     1140

cttgccacca aaagttttgg cagctcctca acttccggca ttacgggcga caatacgaca     1200

acatcctctg agcccgcccc ttctggctgc ccccccgact ccgacgttga gtcctattct     1260

tccatgcccc ccctggaggg ggagcctggg gatccggatc tcagcgacgg gtcatggtcg     1320

acggtcagta gtggggccga cacggaagat gtcgtgtgct gctcaatgtc ttattcctgg     1380

acaggcgcac tcgtcacccc gtgcgctgcg gaagaacaaa aactgcccat caacgcactg     1440

agcaactcgt tgctacgcca tcacaatctg gtgtattcca ccacttcacg cagtgcttgc     1500

caaaggcaga agaaagtcac atttgacaga ctgcaagttc tggacagcca ttaccaggac     1560

gtgctcaagg aggtcaaagc agcggcgtca aaagtgaagg ctaacttgct atccgtagag     1620

gaagcttgca gcctgacgcc cccacattca gccaaatcca agtttggcta tggggcaaaa     1680

gacgtccgtt gccatgccag aaaggccgta gcccacatca actccgtgtg gaaagacctt     1740

ctggaagaca gtgtaacacc aatagacact accatcatgg ccaagaacga ggttttctgc     1800

gttcagcctg agaagggggg tcgtaagcca gctcgtctca tcgtgttccc cgacctgggc     1860

gtgcgcgtgt gcgagaagat ggccctgtac gacgtggtta gcaagctccc cctggccgtg     1920

atgggaagct cctacggatt ccaatactca ccaggacagc gggttgaatt cctcgtgcaa     1980

gcgtggaagt ccaagaagac cccgatgggg ttctcgtatg atacccgctg ttttgactcc     2040

acagtcactg agagcgacat ccgtacggag gaggcaattt accaatgttg tgacctggac     2100

ccccaagccc gcgtggccat caagtccctc actgagaggc tttatgttgg gggccctctt     2160

accaattcaa ggggggaaaa ctgcggctac cgcaggtgcc gcgcgagcgg cgtactgaca     2220

actagctgtg gtaacaccct cacttgctac atcaaggccc gggcagcctg tcgagccgca     2280

gggctccagg actgcaccat gctcgtgtgt ggcgacgact tagtcgttat ctgtgaaagt     2340

gcgggggtcc aggaggacgc ggcgagcctg agagccttca cggaggctat gaccaggtac     2400

tccgcccccc ccggggaccc cccacaacca gaatacgact tggagcttat aacatcatgc     2460

tcctccaacg tgtcagtcgc ccacgacggc gctggaaaga gggtctacta ccttacccgt     2520

gaccctacaa cccccctcgc gagagccgcg tgggagacag caagacacac tccagtcaat     2580

tcctggctag gcaacataat catgtttgcc cccacactgt gggcgaggat gatactgatg     2640

acccatttct ttagcgtcct catagccagg gatcagcttg aacaggctct taactgtgag     2700

atctacggag cctgctactc catagaacca ctggatctac ctccaatcat tcaaagactc     2760

catggcctca gcgcattttc actccacagt tactctccag gtgaaatcaa tagggtggcc     2820

gcatgcctca gaaaacttgg ggtcccgccc ttgcgagctt ggagacaccg ggcccggagc     2880

gtccgcgcta ggcttctgtc cagaggaggc agggctgcca tatgtggcaa gtacctcttc     2940

aactgggcag taagaacaaa gctcaaactc actccaatat ag                        2982


<210>  18
<211>  993
<212>  PRT
<213>  Artificial

<220>
<223>  recombinant fusion protein

<400>  18

Met Ala Asp Glu Ala Pro Ser Gly Ser Trp Leu Arg Asp Ile Trp Asp 
1               5                   10                  15      


Trp Ile Cys Glu Val Leu Ser Asp Phe Lys Thr Trp Leu Lys Ala Lys 
            20                  25                  30          


Leu Met Pro Gln Leu Pro Gly Ile Pro Phe Val Ser Cys Gln Arg Gly 
        35                  40                  45              


Tyr Arg Gly Val Trp Arg Gly Asp Gly Ile Met His Thr Arg Cys His 
    50                  55                  60                  


Cys Gly Ala Glu Ile Thr Gly His Val Lys Asn Gly Thr Met Arg Ile 
65                  70                  75                  80  


Val Gly Pro Arg Thr Cys Arg Asn Met Trp Ser Gly Thr Phe Pro Ile 
                85                  90                  95      


Asn Ala Tyr Thr Thr Gly Pro Cys Thr Pro Leu Pro Ala Pro Asn Tyr 
            100                 105                 110         


Lys Phe Ala Leu Trp Arg Val Ser Ala Glu Glu Tyr Val Glu Ile Arg 
        115                 120                 125             


Arg Val Gly Asp Phe His Tyr Val Ser Gly Met Thr Thr Asp Asn Leu 
    130                 135                 140                 


Lys Cys Pro Cys Gln Ile Pro Ser Pro Glu Phe Phe Thr Glu Leu Asp 
145                 150                 155                 160 


Gly Val Arg Leu His Arg Phe Ala Pro Pro Cys Lys Pro Leu Leu Arg 
                165                 170                 175     


Glu Glu Val Ser Phe Arg Val Gly Leu His Glu Tyr Pro Val Gly Ser 
            180                 185                 190         


Gln Leu Pro Cys Glu Pro Glu Pro Asp Val Ala Val Leu Thr Ser Met 
        195                 200                 205             


Leu Thr Asp Pro Ser His Ile Thr Ala Glu Ala Ala Gly Arg Arg Leu 
    210                 215                 220                 


Ala Arg Gly Ser Pro Pro Ser Met Ala Ser Ser Ser Ala Ser Gln Leu 
225                 230                 235                 240 


Ser Ala Pro Ser Leu Lys Ala Thr Cys Thr Ala Asn His Asp Ser Pro 
                245                 250                 255     


Asp Ala Glu Leu Ile Glu Ala Asn Leu Leu Trp Arg Gln Glu Met Gly 
            260                 265                 270         


Gly Asn Ile Thr Arg Val Glu Ser Glu Asn Lys Val Val Ile Leu Asp 
        275                 280                 285             


Ser Phe Asp Pro Leu Val Ala Glu Glu Asp Glu Arg Glu Val Ser Val 
    290                 295                 300                 


Pro Ala Glu Ile Leu Arg Lys Ser Arg Arg Phe Ala Arg Ala Leu Pro 
305                 310                 315                 320 


Val Trp Ala Arg Pro Asp Tyr Asn Pro Pro Leu Val Glu Thr Trp Lys 
                325                 330                 335     


Lys Pro Asp Tyr Glu Pro Pro Val Val His Gly Cys Pro Leu Pro Pro 
            340                 345                 350         


Pro Arg Ser Pro Pro Val Pro Pro Pro Arg Lys Lys Arg Thr Val Val 
        355                 360                 365             


Leu Thr Glu Ser Thr Leu Ser Thr Ala Leu Ala Glu Leu Ala Thr Lys 
    370                 375                 380                 


Ser Phe Gly Ser Ser Ser Thr Ser Gly Ile Thr Gly Asp Asn Thr Thr 
385                 390                 395                 400 


Thr Ser Ser Glu Pro Ala Pro Ser Gly Cys Pro Pro Asp Ser Asp Val 
                405                 410                 415     


Glu Ser Tyr Ser Ser Met Pro Pro Leu Glu Gly Glu Pro Gly Asp Pro 
            420                 425                 430         


Asp Leu Ser Asp Gly Ser Trp Ser Thr Val Ser Ser Gly Ala Asp Thr 
        435                 440                 445             


Glu Asp Val Val Cys Cys Ser Met Ser Tyr Ser Trp Thr Gly Ala Leu 
    450                 455                 460                 


Val Thr Pro Cys Ala Ala Glu Glu Gln Lys Leu Pro Ile Asn Ala Leu 
465                 470                 475                 480 


Ser Asn Ser Leu Leu Arg His His Asn Leu Val Tyr Ser Thr Thr Ser 
                485                 490                 495     


Arg Ser Ala Cys Gln Arg Gln Lys Lys Val Thr Phe Asp Arg Leu Gln 
            500                 505                 510         


Val Leu Asp Ser His Tyr Gln Asp Val Leu Lys Glu Val Lys Ala Ala 
        515                 520                 525             


Ala Ser Lys Val Lys Ala Asn Leu Leu Ser Val Glu Glu Ala Cys Ser 
    530                 535                 540                 


Leu Thr Pro Pro His Ser Ala Lys Ser Lys Phe Gly Tyr Gly Ala Lys 
545                 550                 555                 560 


Asp Val Arg Cys His Ala Arg Lys Ala Val Ala His Ile Asn Ser Val 
                565                 570                 575     


Trp Lys Asp Leu Leu Glu Asp Ser Val Thr Pro Ile Asp Thr Thr Ile 
            580                 585                 590         


Met Ala Lys Asn Glu Val Phe Cys Val Gln Pro Glu Lys Gly Gly Arg 
        595                 600                 605             


Lys Pro Ala Arg Leu Ile Val Phe Pro Asp Leu Gly Val Arg Val Cys 
    610                 615                 620                 


Glu Lys Met Ala Leu Tyr Asp Val Val Ser Lys Leu Pro Leu Ala Val 
625                 630                 635                 640 


Met Gly Ser Ser Tyr Gly Phe Gln Tyr Ser Pro Gly Gln Arg Val Glu 
                645                 650                 655     


Phe Leu Val Gln Ala Trp Lys Ser Lys Lys Thr Pro Met Gly Phe Ser 
            660                 665                 670         


Tyr Asp Thr Arg Cys Phe Asp Ser Thr Val Thr Glu Ser Asp Ile Arg 
        675                 680                 685             


Thr Glu Glu Ala Ile Tyr Gln Cys Cys Asp Leu Asp Pro Gln Ala Arg 
    690                 695                 700                 


Val Ala Ile Lys Ser Leu Thr Glu Arg Leu Tyr Val Gly Gly Pro Leu 
705                 710                 715                 720 


Thr Asn Ser Arg Gly Glu Asn Cys Gly Tyr Arg Arg Cys Arg Ala Ser 
                725                 730                 735     


Gly Val Leu Thr Thr Ser Cys Gly Asn Thr Leu Thr Cys Tyr Ile Lys 
            740                 745                 750         


Ala Arg Ala Ala Cys Arg Ala Ala Gly Leu Gln Asp Cys Thr Met Leu 
        755                 760                 765             


Val Cys Gly Asp Asp Leu Val Val Ile Cys Glu Ser Ala Gly Val Gln 
    770                 775                 780                 


Glu Asp Ala Ala Ser Leu Arg Ala Phe Thr Glu Ala Met Thr Arg Tyr 
785                 790                 795                 800 


Ser Ala Pro Pro Gly Asp Pro Pro Gln Pro Glu Tyr Asp Leu Glu Leu 
                805                 810                 815     


Ile Thr Ser Cys Ser Ser Asn Val Ser Val Ala His Asp Gly Ala Gly 
            820                 825                 830         


Lys Arg Val Tyr Tyr Leu Thr Arg Asp Pro Thr Thr Pro Leu Ala Arg 
        835                 840                 845             


Ala Ala Trp Glu Thr Ala Arg His Thr Pro Val Asn Ser Trp Leu Gly 
    850                 855                 860                 


Asn Ile Ile Met Phe Ala Pro Thr Leu Trp Ala Arg Met Ile Leu Met 
865                 870                 875                 880 


Thr His Phe Phe Ser Val Leu Ile Ala Arg Asp Gln Leu Glu Gln Ala 
                885                 890                 895     


Leu Asn Cys Glu Ile Tyr Gly Ala Cys Tyr Ser Ile Glu Pro Leu Asp 
            900                 905                 910         


Leu Pro Pro Ile Ile Gln Arg Leu His Gly Leu Ser Ala Phe Ser Leu 
        915                 920                 925             


His Ser Tyr Ser Pro Gly Glu Ile Asn Arg Val Ala Ala Cys Leu Arg 
    930                 935                 940                 


Lys Leu Gly Val Pro Pro Leu Arg Ala Trp Arg His Arg Ala Arg Ser 
945                 950                 955                 960 


Val Arg Ala Arg Leu Leu Ser Arg Gly Gly Arg Ala Ala Ile Cys Gly 
                965                 970                 975     


Lys Tyr Leu Phe Asn Trp Ala Val Arg Thr Lys Leu Lys Leu Thr Pro 
            980                 985                 990         


Ile 
    


<210>  19
<211>  9599
<212>  DNA
<213>  Hepatitis C virus

<400>  19
gccagccccc tgatgggggc gacactccac catgaatcac tcccctgtga ggaactattg       60

tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtgcag cctccaggac      120

cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg gaattgccag      180

gacgaccggg tcctttcttg gataaacccg ctcaatgcct ggagatttgg gcgtgccccc      240

gcaagactgc tagccgagta gtgttgggtc gcgaaaggcc ttgtggtact gcctgatagg      300

gtgcttgcga gtgccccggg aggtctcgta gaccgtgcac catgagcacg aatcctaaac      360

ctcaaagaaa aaccaaacgt aacaccaacc gtcgcccaca ggacgtcaag ttcccgggtg      420

gcggtcagat cgttggtgga gtttacttgt tgccgcgcag gggccctaga ttgggtgtgc      480

gcgcgacgag gaagacttcc gagcggtcgc aacctcgagg tagacgtcag cctatcccca      540

aggcacgtcg gcccgagggc aggacctggg ctcagcccgg gtacccttgg cccctctatg      600

gcaatgaggg ttgcgggtgg gcgggatggc tcctgtctcc ccgtggctct cggcctagct      660

ggggccccac agacccccgg cgtaggtcgc gcaatttggg taaggtcatc gataccctta      720

cgtgcggctt cgccgacctc atggggtaca taccgctcgt cggcgcccct cttggaggcg      780

ctgccagggc cctggcgcat ggcgtccggg ttctggaaga cggcgtgaac tatgcaacag      840

ggaaccttcc tggttgctct ttctctatct tccttctggc cctgctctct tgcctgactg      900

tgcccgcttc agcctaccaa gtgcgcaatt cctcggggct ttaccatgtc accaatgatt      960

gccctaactc gagtattgtg tacgaggcgg ccgatgccat cctgcacact ccggggtgtg     1020

tcccttgcgt tcgcgagggt aacgcctcga ggtgttgggt ggcggtgacc cccacggtgg     1080

ccaccaggga cggcaaactc cccacaacgc agcttcgacg tcatatcgat ctgcttgtcg     1140

ggagcgccac cctctgctcg gccctctacg tgggggacct gtgcgggtct gtctttcttg     1200

ttggtcaact gtttaccttc tctcccaggc gccactggac gacgcaagac tgcaattgtt     1260

ctatctatcc cggccatata acgggtcatc gcatggcatg ggatatgatg atgaactggt     1320

cccctacggc agcgttggtg gtagctcagc tgctccggat cccacaagcc atcatggaca     1380

tgatcgctgg tgctcactgg ggagtcctgg cgggcatagc gtatttctcc atggtgggga     1440

actgggcgaa ggtcctggta gtgctgctgc tatttgccgg cgtcgacgcg gaaacccacg     1500

tcaccggggg aaatgccggc cgcaccacgg ctgggcttgt tggtctcctt acaccaggcg     1560

ccaagcagaa catccaactg atcaacacca acggcagttg gcacatcaat agcacggcct     1620

tgaactgcaa tgaaagcctt aacaccggct ggttagcagg gctcttctat cagcacaaat     1680

tcaactcttc aggctgtcct gagaggttga ccagctgccg acgccttacc gattttgccc     1740

agggctgggg tcctatcagt tatgccaacg gaagcggcct cgacgaacgc ccctactgct     1800

ggcactaccc tccaagacct tgtggcattg tgcccgcaaa gagcgtgtgt ggcccggtat     1860

attgcttcac tcccagcccc gtggtggtgg gaacgaccga caggtcgggc gcgcctacct     1920

acagctgggg tgcaaatgat acggacgtct tcgtccttaa caacaccagg ccaccgctgg     1980

gcaattggtt cggttgtacc tggatgaact caactggatt caccaaagtg tgcggagcgc     2040

ccccttgtgt catcggaggg gtgggcaaca acaccttgct ctgccccact gattgcttcc     2100

gcaaacatcc ggaagccaca tactctcggt gcggctccgg tccctggatt acacccaggt     2160

gcatggtcga ctacccgtat aggctttggc actatccttg taccatcaat tacaccatat     2220

tcaaagtcag gatgtacgtg ggaggggtcg agcacaggct ggaagcggcc tgcaactgga     2280

cgcggggcga acgctgtgat ctggaagaca gggacaggtc cgagctcagc ccgttgctgc     2340

tgtccaccac acagtggcag gtccttccgt gttctttcac gaccctgcca gccttgtcca     2400

ccggcctcat ccacctccac cagaacattg tggacgtgca gtacttgtac ggggtagggt     2460

caagcatcgc gtcctgggcc attaagtggg agtacgtcgt tctcctgttc cttctgcttg     2520

cagacgcgcg cgtctgctcc tgcttgtgga tgatgttact catatcccaa gcggaggcgg     2580

ctttggagaa cctcgtaata ctcaatgcag catccctggc cgggacgcac ggtcttgtgt     2640

ccttcctcgt gttcttctgc tttgcgtggt atctgaaggg taggtgggtg cccggagcgg     2700

cctacgcctt ctacgggatg tggcctctcc tcctgctcct gctggcgttg cctcagcggg     2760

catacgcact ggacacggag gtggccgcgt cgtgtggcgg cgttgttctt gtcgggttaa     2820

tggcgctgac tctgtcgcca tattacaagc gctatatcag ctggtgcatg tggtggcttc     2880

agtattttct gaccagagta gaagcgcaac tgcacgtgtg ggttcccccc ctcaacgtcc     2940

ggggggggcg cgatgccgtc atcttactca tgtgtgtagt acacccgacc ctggtatttg     3000

acatcaccaa actactcctg gccatcttcg gacccctttg gattcttcaa gccagtttgc     3060

ttaaagtccc ctacttcgtg cgcgttcaag gccttctccg gatctgcgcg ctagcgcgga     3120

agatagccgg aggtcattac gtgcaaatgg ccatcatcaa gttaggggcg cttactggca     3180

cctatgtgta taaccatctc acccctcttc gagactgggc gcacaacggc ctgcgagatc     3240

tggccgtggc tgtggaacca gtcgttttct cccgaatgga gaccaagctc atcacgtggg     3300

gggcagatac cgccgcgtgc ggtgacatca tcaacggctt gcccgtctct gcccgtaggg     3360

gccaggagat actgcttggg ccagccgacg gaatggtctc caaggggtgg aggttgcagg     3420

cgcccatcac ggcgtacacc cagcagacga gaggcctcct agggtgtata atcaccagcc     3480

tgactggccg ggacaaaaac caagtggagg gtgaggtcca gatcgtgtca actgctaccc     3540

aaaccttcct ggcaacgtgc atcaatgggg tatgctggac tgtctaccac ggggccggaa     3600

cgaggaccat cgcatcaccc aagggtcctg tcatccagat gtataccaat gtggaccaag     3660

accttgtggg ctggcccgct cctcaaggtt cccgctcatt ggcaccctgc acctgcggct     3720

cctcggacct ttacctggtc acgaggcacg ccgatgtcat tcccgtgcgc cggcgaggtg     3780

atagcagggg tagcctgctt tcgccccggc ccatttccta cttgaaaggc tcctcggggg     3840

gtccgctgtt gtgccccgcg ggacacgccg tgggcctatt cagggccgcg gtgtgcaccc     3900

gtggagtggc taaggcggtg gactttatcc ctgtggagaa cctagggaca accatgagat     3960

ccccggtgtt cacggacaac tcctctccac cagcagtgcc ccagagcttc caggtggccc     4020

acctgcatgc tcccaccggc agcggtaaga gcaccaaggt cccggctgcg tacgcagccc     4080

agggctacaa ggtgttggtg ctcaacccct ctgttgctgc aacgctgggc tttggtgctt     4140

acatgtccaa ggcccatggg gttgatccta atatcaggac cggggtgaga acaattacca     4200

ctggcagccc catcacgtac tccacctacg gcaagttcct tgccgacggc gggtgctcag     4260

gaggtgctta tgacataata atttgtgacg agtgccactc cacggatgcc acatccatct     4320

tgggcatcgg cactgtcctt gaccaagcag agactgcggg ggcgagactg gttgtgctcg     4380

ccactgctac ccctccgggc tccgtcactg tgtcccatcc taacatcgag gaggttgctc     4440

tgtccaccac cggagagatc cccttttacg gcaaggctat ccccctcgag gtgatcaagg     4500

ggggaagaca tctcatcttc tgccattcaa agaagaagtg cgacgagctc gccgcgaagc     4560

tggtcgcatt gggcatcaat gccgtggcct actaccgcgg tcttgacgtg tctgtcatcc     4620

cgaccagcgg cgatgttgtc gtcgtgtcga ccgatgctct catgactggc tttaccggcg     4680

acttcgactc tgtgatagac tgcaacacgt gtgtcactca gacagtcgat ttcagccttg     4740

accctacctt taccattgag acaaccacgc tcccccagga tgctgtctcc aggactcaac     4800

gccggggcag gaccggcagg gggaagccag gcatctatag atttgtggca ccgggggagc     4860

gcccctccgg catgttcgac tcgtccgtcc tctgtgagtg ctatgacgcg ggctgtgctt     4920

ggtatgagct cacgcccgcc gagactacag ttaggctacg agcgtacatg aacaccccgg     4980

ggcttcccgt gtgccaggac catcttgaat tttgggaggg cgtctttacg ggcctcactc     5040

atatagatgc ccactttcta tcccagacaa agcagagtgg ggagaacttt ccttacctgg     5100

tagcgtacca agccaccgtg tgcgctaggg ctcaagcccc tcccccatcg tgggaccaga     5160

tgtggaagtg tttgatccgc cttaaaccca ccctccatgg gccaacaccc ctgctataca     5220

gactgggcgc tgttcagaat gaagtcaccc tgacgcaccc aatcaccaaa tacatcatga     5280

catgcatgtc ggccgacctg gaggtcgtca cgagcacctg ggtgctcgtt ggcggcgtcc     5340

tggctgctct ggccgcgtat tgcctgtcaa caggctgcgt ggtcatagtg ggcaggatcg     5400

tcttgtccgg gaagccggca attatacctg acagggaggt tctctaccag gagttcgatg     5460

agatggaaga gtgctctcag cacttaccgt acatcgagca agggatgatg ctcgctgagc     5520

agttcaagca gaaggccctc ggcctcctgc agaccgcgtc ccgccatgca gaggttatca     5580

cccctgctgt ccagaccaac tggcagaaac tcgaggtctt ttgggcgaag cacatgtgga     5640

atttcatcag tgggatacaa tacttggcgg gcctgtcaac gctgcctggt aaccccgcca     5700

ttgcttcatt gatggctttt acagctgccg tcaccagccc actaaccact ggccaaaccc     5760

tcctcttcaa catattgggg gggtgggtgg ctgcccagct cgccgccccc ggtgccgcta     5820

ctgcctttgt gggcgctggc ctagctggcg ccgccatcgg cagcgttgga ctggggaagg     5880

tcctcgtgga cattcttgca gggtatggcg cgggcgtggc gggagctctt gtagcattca     5940

agatcatgag cggtgaggtc ccctccacgg aggacctggt caatctgctg cccgccatcc     6000

tctcgcctgg agcccttgta gtcggtgtgg tctgcgcagc aatactgcgc cggcacgttg     6060

gcccgggcga gggggcagtg caatggatga accggctaat agccttcgcc tcccggggga     6120

accatgtttc ccccacgcac tacgtgccgg agagcgatgc agccgcccgc gtcactgcca     6180

tactcagcag cctcactgta acccagctcc tgaggcgact gcatcagtgg ataagctcgg     6240

agtgtaccac tccatgctcc ggttcctggc taagggacat ctgggactgg atatgcgagg     6300

tgctgagcga ctttaagacc tggctgaaag ccaagctcat gccacaactg cctgggattc     6360

cctttgtgtc ctgccagcgc gggtataggg gggtctggcg aggagacggc attatgcaca     6420

ctcgctgcca ctgtggagct gagatcactg gacatgtcaa aaacgggacg atgaggatcg     6480

tcggtcctag gacttgcagg aacatgtgga gtgggacgtt ccccattaac gcctacacca     6540

cgggcccctg tactcccctt cctgcgccga actataagtt cgcgctgtgg agggtgtctg     6600

cagaggaata cgtggagata aggcgggtgg gggacttcca ctacgtatcg ggtatgacta     6660

ctgacaatct taaatgcccg tgccagatcc catcgcccga atttttcaca gaattggacg     6720

gggtgcgcct acacaggttt gcgccccctt gcaagccctt gctgcgggag gaggtatcat     6780

tcagagtagg actccacgag tacccggtgg ggtcgcaatt accttgcgag cccgaaccgg     6840

acgtagccgt gttgacgtcc atgctcactg atccctccca tataacagca gaggcggccg     6900

ggagaaggtt ggcgagaggg tcaccccctt ctatggccag ctcctcggct agccagctgt     6960

ccgctccatc tctcaaggca acttgcaccg ccaaccatga ctcccctgac gccgagctca     7020

tagaggctaa cctcctgtgg aggcaggaga tgggcggcaa catcaccagg gttgagtcag     7080

agaacaaagt ggtgattctg gactccttcg atccgcttgt ggcagaggag gatgagcggg     7140

aggtctccgt acctgcagaa attctgcgga agtctcggag attcgcccgg gccctgcccg     7200

tctgggcgcg gccggactac aaccccccgc tagtagagac gtggaaaaag cctgactacg     7260

aaccacctgt ggtccatggc tgcccgctac cacctccacg gtcccctcct gtgcctccgc     7320

ctcggaaaaa gcgtacggtg gtcctcaccg aatcaaccct atctactgcc ttggccgagc     7380

ttgccaccaa aagttttggc agctcctcaa cttccggcat tacgggcgac aatacgacaa     7440

catcctctga gcccgcccct tctggctgcc cccccgactc cgacgttgag tcctattctt     7500

ccatgccccc cctggagggg gagcctgggg atccggatct cagcgacggg tcatggtcga     7560

cggtcagtag tggggccgac acggaagatg tcgtgtgctg ctcaatgtct tattcctgga     7620

caggcgcact cgtcaccccg tgcgctgcgg aagaacaaaa actgcccatc aacgcactga     7680

gcaactcgtt gctacgccat cacaatctgg tgtattccac cacttcacgc agtgcttgcc     7740

aaaggcagaa gaaagtcaca tttgacagac tgcaagttct ggacagccat taccaggacg     7800

tgctcaagga ggtcaaagca gcggcgtcaa aagtgaaggc taacttgcta tccgtagagg     7860

aagcttgcag cctgacgccc ccacattcag ccaaatccaa gtttggctat ggggcaaaag     7920

acgtccgttg ccatgccaga aaggccgtag cccacatcaa ctccgtgtgg aaagaccttc     7980

tggaagacag tgtaacacca atagacacta ccatcatggc caagaacgag gttttctgcg     8040

ttcagcctga gaaggggggt cgtaagccag ctcgtctcat cgtgttcccc gacctgggcg     8100

tgcgcgtgtg cgagaagatg gccctgtacg acgtggttag caagctcccc ctggccgtga     8160

tgggaagctc ctacggattc caatactcac caggacagcg ggttgaattc ctcgtgcaag     8220

cgtggaagtc caagaagacc ccgatggggt tctcgtatga tacccgctgt tttgactcca     8280

cagtcactga gagcgacatc cgtacggagg aggcaattta ccaatgttgt gacctggacc     8340

cccaagcccg cgtggccatc aagtccctca ctgagaggct ttatgttggg ggccctctta     8400

ccaattcaag gggggaaaac tgcggctacc gcaggtgccg cgcgagcggc gtactgacaa     8460

ctagctgtgg taacaccctc acttgctaca tcaaggcccg ggcagcctgt cgagccgcag     8520

ggctccagga ctgcaccatg ctcgtgtgtg gcgacgactt agtcgttatc tgtgaaagtg     8580

cgggggtcca ggaggacgcg gcgaacctga gagccttcac ggaggctatg accaggtact     8640

ccgccccccc cggggacccc ccacaaccag aatacgactt ggagcttata acatcatgct     8700

cctccaacgt gtcagtcgcc cacgacggcg ctggaaagag ggtctactac cttacccgtg     8760

accctacaac ccccctcgcg agagccgcgt gggagacagc aagacacact ccagtcaatt     8820

cctggctagg caacataatc atgtttgccc ccacactgtg ggcgaggatg atactgatga     8880

cccatttctt tagcgtcctc atagccaggg atcagcttga acaggctctt aactgtgaga     8940

tctacggagc ctgctactcc atagaaccac tggatctacc tccaatcatt caaagactcc     9000

atggcctcag cgcattttca ctccacagtt actctccagg tgaaatcaat agggtggccg     9060

catgcctcag aaaacttggg gtcccgccct tgcgagcttg gagacaccgg gcccggagcg     9120

tccgcgctag gcttctgtcc agaggaggca gggctgccat atgtggcaag tacctcttca     9180

actgggcagt aagaacaaag ctcaaactca ccccaataac ggccgctggc cggctggact     9240

tgtccggttg gttcacggct ggctacagcg ggggagacat ttatcacagc gtgtctcatg     9300

cccggccccg ctggttctgg ttttgcctac tcctgctcgc tgcaggggta ggcatctacc     9360

tcctccccaa ccgatgaagg ttggggtaaa cactccggcc tcttaagcca tttcctgttt     9420

tttttttttt tttttttttt tttttctttt tttttttctt tcctttcctt ctttttttcc     9480

tttctttttc ccttctttaa tggtggctcc atcttagccc tagtcacggc tagctgtgaa     9540

aggtccgtga gccgcatgac tgcagagagt gctgatactg gcctctctgc agatcatgt      9599


<210>  20
<211>  3011
<212>  PRT
<213>  Hepatitis C virus

<400>  20

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Ala Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Val Thr Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Val Val Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Met Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr His Val Thr Gly Gly Asn Ala Gly Arg Thr Thr Ala Gly Leu Val 
385                 390                 395                 400 


Gly Leu Leu Thr Pro Gly Ala Lys Gln Asn Ile Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Glu Ser 
            420                 425                 430         


Leu Asn Thr Gly Trp Leu Ala Gly Leu Phe Tyr Gln His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Thr Ser Cys Arg Arg Leu Thr Asp 
    450                 455                 460                 


Phe Ala Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Leu 
465                 470                 475                 480 


Asp Glu Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Ala Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Val Gly Asn 
                565                 570                 575     


Asn Thr Leu Leu Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Met 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr 
    610                 615                 620                 


Thr Ile Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Ala Ser Trp Ala Ile Lys Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala Ala Leu Glu Asn Leu Val 
            740                 745                 750         


Ile Leu Asn Ala Ala Ser Leu Ala Gly Thr His Gly Leu Val Ser Phe 
        755                 760                 765             


Leu Val Phe Phe Cys Phe Ala Trp Tyr Leu Lys Gly Arg Trp Val Pro 
    770                 775                 780                 


Gly Ala Ala Tyr Ala Phe Tyr Gly Met Trp Pro Leu Leu Leu Leu Leu 
785                 790                 795                 800 


Leu Ala Leu Pro Gln Arg Ala Tyr Ala Leu Asp Thr Glu Val Ala Ala 
                805                 810                 815     


Ser Cys Gly Gly Val Val Leu Val Gly Leu Met Ala Leu Thr Leu Ser 
            820                 825                 830         


Pro Tyr Tyr Lys Arg Tyr Ile Ser Trp Cys Met Trp Trp Leu Gln Tyr 
        835                 840                 845             


Phe Leu Thr Arg Val Glu Ala Gln Leu His Val Trp Val Pro Pro Leu 
    850                 855                 860                 


Asn Val Arg Gly Gly Arg Asp Ala Val Ile Leu Leu Met Cys Val Val 
865                 870                 875                 880 


His Pro Thr Leu Val Phe Asp Ile Thr Lys Leu Leu Leu Ala Ile Phe 
                885                 890                 895     


Gly Pro Leu Trp Ile Leu Gln Ala Ser Leu Leu Lys Val Pro Tyr Phe 
            900                 905                 910         


Val Arg Val Gln Gly Leu Leu Arg Ile Cys Ala Leu Ala Arg Lys Ile 
        915                 920                 925             


Ala Gly Gly His Tyr Val Gln Met Ala Ile Ile Lys Leu Gly Ala Leu 
    930                 935                 940                 


Thr Gly Thr Tyr Val Tyr Asn His Leu Thr Pro Leu Arg Asp Trp Ala 
945                 950                 955                 960 


His Asn Gly Leu Arg Asp Leu Ala Val Ala Val Glu Pro Val Val Phe 
                965                 970                 975     


Ser Arg Met Glu Thr Lys Leu Ile Thr Trp Gly Ala Asp Thr Ala Ala 
            980                 985                 990         


Cys Gly Asp Ile Ile Asn Gly Leu  Pro Val Ser Ala Arg  Arg Gly Gln 
        995                 1000                 1005             


Glu Ile  Leu Leu Gly Pro Ala  Asp Gly Met Val Ser  Lys Gly Trp 
    1010                 1015                 1020             


Arg Leu  Gln Ala Pro Ile Thr  Ala Tyr Thr Gln Gln  Thr Arg Gly 
    1025                 1030                 1035             


Leu Leu  Gly Cys Ile Ile Thr  Ser Leu Thr Gly Arg  Asp Lys Asn 
    1040                 1045                 1050             


Gln Val  Glu Gly Glu Val Gln  Ile Val Ser Thr Ala  Thr Gln Thr 
    1055                 1060                 1065             


Phe Leu  Ala Thr Cys Ile Asn  Gly Val Cys Trp Thr  Val Tyr His 
    1070                 1075                 1080             


Gly Ala  Gly Thr Arg Thr Ile  Ala Ser Pro Lys Gly  Pro Val Ile 
    1085                 1090                 1095             


Gln Met  Tyr Thr Asn Val Asp  Gln Asp Leu Val Gly  Trp Pro Ala 
    1100                 1105                 1110             


Pro Gln  Gly Ser Arg Ser Leu  Ala Pro Cys Thr Cys  Gly Ser Ser 
    1115                 1120                 1125             


Asp Leu  Tyr Leu Val Thr Arg  His Ala Asp Val Ile  Pro Val Arg 
    1130                 1135                 1140             


Arg Arg  Gly Asp Ser Arg Gly  Ser Leu Leu Ser Pro  Arg Pro Ile 
    1145                 1150                 1155             


Ser Tyr  Leu Lys Gly Ser Ser  Gly Gly Pro Leu Leu  Cys Pro Ala 
    1160                 1165                 1170             


Gly His  Ala Val Gly Leu Phe  Arg Ala Ala Val Cys  Thr Arg Gly 
    1175                 1180                 1185             


Val Ala  Lys Ala Val Asp Phe  Ile Pro Val Glu Asn  Leu Gly Thr 
    1190                 1195                 1200             


Thr Met  Arg Ser Pro Val Phe  Thr Asp Asn Ser Ser  Pro Pro Ala 
    1205                 1210                 1215             


Val Pro  Gln Ser Phe Gln Val  Ala His Leu His Ala  Pro Thr Gly 
    1220                 1225                 1230             


Ser Gly  Lys Ser Thr Lys Val  Pro Ala Ala Tyr Ala  Ala Gln Gly 
    1235                 1240                 1245             


Tyr Lys  Val Leu Val Leu Asn  Pro Ser Val Ala Ala  Thr Leu Gly 
    1250                 1255                 1260             


Phe Gly  Ala Tyr Met Ser Lys  Ala His Gly Val Asp  Pro Asn Ile 
    1265                 1270                 1275             


Arg Thr  Gly Val Arg Thr Ile  Thr Thr Gly Ser Pro  Ile Thr Tyr 
    1280                 1285                 1290             


Ser Thr  Tyr Gly Lys Phe Leu  Ala Asp Gly Gly Cys  Ser Gly Gly 
    1295                 1300                 1305             


Ala Tyr  Asp Ile Ile Ile Cys  Asp Glu Cys His Ser  Thr Asp Ala 
    1310                 1315                 1320             


Thr Ser  Ile Leu Gly Ile Gly  Thr Val Leu Asp Gln  Ala Glu Thr 
    1325                 1330                 1335             


Ala Gly  Ala Arg Leu Val Val  Leu Ala Thr Ala Thr  Pro Pro Gly 
    1340                 1345                 1350             


Ser Val  Thr Val Ser His Pro  Asn Ile Glu Glu Val  Ala Leu Ser 
    1355                 1360                 1365             


Thr Thr  Gly Glu Ile Pro Phe  Tyr Gly Lys Ala Ile  Pro Leu Glu 
    1370                 1375                 1380             


Val Ile  Lys Gly Gly Arg His  Leu Ile Phe Cys His  Ser Lys Lys 
    1385                 1390                 1395             


Lys Cys  Asp Glu Leu Ala Ala  Lys Leu Val Ala Leu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Val  Ala Tyr Tyr Arg Gly  Leu Asp Val Ser Val  Ile Pro Thr 
    1415                 1420                 1425             


Ser Gly  Asp Val Val Val Val  Ser Thr Asp Ala Leu  Met Thr Gly 
    1430                 1435                 1440             


Phe Thr  Gly Asp Phe Asp Ser  Val Ile Asp Cys Asn  Thr Cys Val 
    1445                 1450                 1455             


Thr Gln  Thr Val Asp Phe Ser  Leu Asp Pro Thr Phe  Thr Ile Glu 
    1460                 1465                 1470             


Thr Thr  Thr Leu Pro Gln Asp  Ala Val Ser Arg Thr  Gln Arg Arg 
    1475                 1480                 1485             


Gly Arg  Thr Gly Arg Gly Lys  Pro Gly Ile Tyr Arg  Phe Val Ala 
    1490                 1495                 1500             


Pro Gly  Glu Arg Pro Ser Gly  Met Phe Asp Ser Ser  Val Leu Cys 
    1505                 1510                 1515             


Glu Cys  Tyr Asp Ala Gly Cys  Ala Trp Tyr Glu Leu  Thr Pro Ala 
    1520                 1525                 1530             


Glu Thr  Thr Val Arg Leu Arg  Ala Tyr Met Asn Thr  Pro Gly Leu 
    1535                 1540                 1545             


Pro Val  Cys Gln Asp His Leu  Glu Phe Trp Glu Gly  Val Phe Thr 
    1550                 1555                 1560             


Gly Leu  Thr His Ile Asp Ala  His Phe Leu Ser Gln  Thr Lys Gln 
    1565                 1570                 1575             


Ser Gly  Glu Asn Phe Pro Tyr  Leu Val Ala Tyr Gln  Ala Thr Val 
    1580                 1585                 1590             


Cys Ala  Arg Ala Gln Ala Pro  Pro Pro Ser Trp Asp  Gln Met Trp 
    1595                 1600                 1605             


Lys Cys  Leu Ile Arg Leu Lys  Pro Thr Leu His Gly  Pro Thr Pro 
    1610                 1615                 1620             


Leu Leu  Tyr Arg Leu Gly Ala  Val Gln Asn Glu Val  Thr Leu Thr 
    1625                 1630                 1635             


His Pro  Ile Thr Lys Tyr Ile  Met Thr Cys Met Ser  Ala Asp Leu 
    1640                 1645                 1650             


Glu Val  Val Thr Ser Thr Trp  Val Leu Val Gly Gly  Val Leu Ala 
    1655                 1660                 1665             


Ala Leu  Ala Ala Tyr Cys Leu  Ser Thr Gly Cys Val  Val Ile Val 
    1670                 1675                 1680             


Gly Arg  Ile Val Leu Ser Gly  Lys Pro Ala Ile Ile  Pro Asp Arg 
    1685                 1690                 1695             


Glu Val  Leu Tyr Gln Glu Phe  Asp Glu Met Glu Glu  Cys Ser Gln 
    1700                 1705                 1710             


His Leu  Pro Tyr Ile Glu Gln  Gly Met Met Leu Ala  Glu Gln Phe 
    1715                 1720                 1725             


Lys Gln  Lys Ala Leu Gly Leu  Leu Gln Thr Ala Ser  Arg His Ala 
    1730                 1735                 1740             


Glu Val  Ile Thr Pro Ala Val  Gln Thr Asn Trp Gln  Lys Leu Glu 
    1745                 1750                 1755             


Val Phe  Trp Ala Lys His Met  Trp Asn Phe Ile Ser  Gly Ile Gln 
    1760                 1765                 1770             


Tyr Leu  Ala Gly Leu Ser Thr  Leu Pro Gly Asn Pro  Ala Ile Ala 
    1775                 1780                 1785             


Ser Leu  Met Ala Phe Thr Ala  Ala Val Thr Ser Pro  Leu Thr Thr 
    1790                 1795                 1800             


Gly Gln  Thr Leu Leu Phe Asn  Ile Leu Gly Gly Trp  Val Ala Ala 
    1805                 1810                 1815             


Gln Leu  Ala Ala Pro Gly Ala  Ala Thr Ala Phe Val  Gly Ala Gly 
    1820                 1825                 1830             


Leu Ala  Gly Ala Ala Ile Gly  Ser Val Gly Leu Gly  Lys Val Leu 
    1835                 1840                 1845             


Val Asp  Ile Leu Ala Gly Tyr  Gly Ala Gly Val Ala  Gly Ala Leu 
    1850                 1855                 1860             


Val Ala  Phe Lys Ile Met Ser  Gly Glu Val Pro Ser  Thr Glu Asp 
    1865                 1870                 1875             


Leu Val  Asn Leu Leu Pro Ala  Ile Leu Ser Pro Gly  Ala Leu Val 
    1880                 1885                 1890             


Val Gly  Val Val Cys Ala Ala  Ile Leu Arg Arg His  Val Gly Pro 
    1895                 1900                 1905             


Gly Glu  Gly Ala Val Gln Trp  Met Asn Arg Leu Ile  Ala Phe Ala 
    1910                 1915                 1920             


Ser Arg  Gly Asn His Val Ser  Pro Thr His Tyr Val  Pro Glu Ser 
    1925                 1930                 1935             


Asp Ala  Ala Ala Arg Val Thr  Ala Ile Leu Ser Ser  Leu Thr Val 
    1940                 1945                 1950             


Thr Gln  Leu Leu Arg Arg Leu  His Gln Trp Ile Ser  Ser Glu Cys 
    1955                 1960                 1965             


Thr Thr  Pro Cys Ser Gly Ser  Trp Leu Arg Asp Ile  Trp Asp Trp 
    1970                 1975                 1980             


Ile Cys  Glu Val Leu Ser Asp  Phe Lys Thr Trp Leu  Lys Ala Lys 
    1985                 1990                 1995             


Leu Met  Pro Gln Leu Pro Gly  Ile Pro Phe Val Ser  Cys Gln Arg 
    2000                 2005                 2010             


Gly Tyr  Arg Gly Val Trp Arg  Gly Asp Gly Ile Met  His Thr Arg 
    2015                 2020                 2025             


Cys His  Cys Gly Ala Glu Ile  Thr Gly His Val Lys  Asn Gly Thr 
    2030                 2035                 2040             


Met Arg  Ile Val Gly Pro Arg  Thr Cys Arg Asn Met  Trp Ser Gly 
    2045                 2050                 2055             


Thr Phe  Pro Ile Asn Ala Tyr  Thr Thr Gly Pro Cys  Thr Pro Leu 
    2060                 2065                 2070             


Pro Ala  Pro Asn Tyr Lys Phe  Ala Leu Trp Arg Val  Ser Ala Glu 
    2075                 2080                 2085             


Glu Tyr  Val Glu Ile Arg Arg  Val Gly Asp Phe His  Tyr Val Ser 
    2090                 2095                 2100             


Gly Met  Thr Thr Asp Asn Leu  Lys Cys Pro Cys Gln  Ile Pro Ser 
    2105                 2110                 2115             


Pro Glu  Phe Phe Thr Glu Leu  Asp Gly Val Arg Leu  His Arg Phe 
    2120                 2125                 2130             


Ala Pro  Pro Cys Lys Pro Leu  Leu Arg Glu Glu Val  Ser Phe Arg 
    2135                 2140                 2145             


Val Gly  Leu His Glu Tyr Pro  Val Gly Ser Gln Leu  Pro Cys Glu 
    2150                 2155                 2160             


Pro Glu  Pro Asp Val Ala Val  Leu Thr Ser Met Leu  Thr Asp Pro 
    2165                 2170                 2175             


Ser His  Ile Thr Ala Glu Ala  Ala Gly Arg Arg Leu  Ala Arg Gly 
    2180                 2185                 2190             


Ser Pro  Pro Ser Met Ala Ser  Ser Ser Ala Ser Gln  Leu Ser Ala 
    2195                 2200                 2205             


Pro Ser  Leu Lys Ala Thr Cys  Thr Ala Asn His Asp  Ser Pro Asp 
    2210                 2215                 2220             


Ala Glu  Leu Ile Glu Ala Asn  Leu Leu Trp Arg Gln  Glu Met Gly 
    2225                 2230                 2235             


Gly Asn  Ile Thr Arg Val Glu  Ser Glu Asn Lys Val  Val Ile Leu 
    2240                 2245                 2250             


Asp Ser  Phe Asp Pro Leu Val  Ala Glu Glu Asp Glu  Arg Glu Val 
    2255                 2260                 2265             


Ser Val  Pro Ala Glu Ile Leu  Arg Lys Ser Arg Arg  Phe Ala Arg 
    2270                 2275                 2280             


Ala Leu  Pro Val Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Thr  Trp Lys Lys Pro Asp  Tyr Glu Pro Pro Val  Val His Gly 
    2300                 2305                 2310             


Cys Pro  Leu Pro Pro Pro Arg  Ser Pro Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Lys Lys  Arg Thr Val Val Leu  Thr Glu Ser Thr Leu  Ser Thr Ala 
    2330                 2335                 2340             


Leu Ala  Glu Leu Ala Thr Lys  Ser Phe Gly Ser Ser  Ser Thr Ser 
    2345                 2350                 2355             


Gly Ile  Thr Gly Asp Asn Thr  Thr Thr Ser Ser Glu  Pro Ala Pro 
    2360                 2365                 2370             


Ser Gly  Cys Pro Pro Asp Ser  Asp Val Glu Ser Tyr  Ser Ser Met 
    2375                 2380                 2385             


Pro Pro  Leu Glu Gly Glu Pro  Gly Asp Pro Asp Leu  Ser Asp Gly 
    2390                 2395                 2400             


Ser Trp  Ser Thr Val Ser Ser  Gly Ala Asp Thr Glu  Asp Val Val 
    2405                 2410                 2415             


Cys Cys  Ser Met Ser Tyr Ser  Trp Thr Gly Ala Leu  Val Thr Pro 
    2420                 2425                 2430             


Cys Ala  Ala Glu Glu Gln Lys  Leu Pro Ile Asn Ala  Leu Ser Asn 
    2435                 2440                 2445             


Ser Leu  Leu Arg His His Asn  Leu Val Tyr Ser Thr  Thr Ser Arg 
    2450                 2455                 2460             


Ser Ala  Cys Gln Arg Gln Lys  Lys Val Thr Phe Asp  Arg Leu Gln 
    2465                 2470                 2475             


Val Leu  Asp Ser His Tyr Gln  Asp Val Leu Lys Glu  Val Lys Ala 
    2480                 2485                 2490             


Ala Ala  Ser Lys Val Lys Ala  Asn Leu Leu Ser Val  Glu Glu Ala 
    2495                 2500                 2505             


Cys Ser  Leu Thr Pro Pro His  Ser Ala Lys Ser Lys  Phe Gly Tyr 
    2510                 2515                 2520             


Gly Ala  Lys Asp Val Arg Cys  His Ala Arg Lys Ala  Val Ala His 
    2525                 2530                 2535             


Ile Asn  Ser Val Trp Lys Asp  Leu Leu Glu Asp Ser  Val Thr Pro 
    2540                 2545                 2550             


Ile Asp  Thr Thr Ile Met Ala  Lys Asn Glu Val Phe  Cys Val Gln 
    2555                 2560                 2565             


Pro Glu  Lys Gly Gly Arg Lys  Pro Ala Arg Leu Ile  Val Phe Pro 
    2570                 2575                 2580             


Asp Leu  Gly Val Arg Val Cys  Glu Lys Met Ala Leu  Tyr Asp Val 
    2585                 2590                 2595             


Val Ser  Lys Leu Pro Leu Ala  Val Met Gly Ser Ser  Tyr Gly Phe 
    2600                 2605                 2610             


Gln Tyr  Ser Pro Gly Gln Arg  Val Glu Phe Leu Val  Gln Ala Trp 
    2615                 2620                 2625             


Lys Ser  Lys Lys Thr Pro Met  Gly Phe Ser Tyr Asp  Thr Arg Cys 
    2630                 2635                 2640             


Phe Asp  Ser Thr Val Thr Glu  Ser Asp Ile Arg Thr  Glu Glu Ala 
    2645                 2650                 2655             


Ile Tyr  Gln Cys Cys Asp Leu  Asp Pro Gln Ala Arg  Val Ala Ile 
    2660                 2665                 2670             


Lys Ser  Leu Thr Glu Arg Leu  Tyr Val Gly Gly Pro  Leu Thr Asn 
    2675                 2680                 2685             


Ser Arg  Gly Glu Asn Cys Gly  Tyr Arg Arg Cys Arg  Ala Ser Gly 
    2690                 2695                 2700             


Val Leu  Thr Thr Ser Cys Gly  Asn Thr Leu Thr Cys  Tyr Ile Lys 
    2705                 2710                 2715             


Ala Arg  Ala Ala Cys Arg Ala  Ala Gly Leu Gln Asp  Cys Thr Met 
    2720                 2725                 2730             


Leu Val  Cys Gly Asp Asp Leu  Val Val Ile Cys Glu  Ser Ala Gly 
    2735                 2740                 2745             


Val Gln  Glu Asp Ala Ala Asn  Leu Arg Ala Phe Thr  Glu Ala Met 
    2750                 2755                 2760             


Thr Arg  Tyr Ser Ala Pro Pro  Gly Asp Pro Pro Gln  Pro Glu Tyr 
    2765                 2770                 2775             


Asp Leu  Glu Leu Ile Thr Ser  Cys Ser Ser Asn Val  Ser Val Ala 
    2780                 2785                 2790             


His Asp  Gly Ala Gly Lys Arg  Val Tyr Tyr Leu Thr  Arg Asp Pro 
    2795                 2800                 2805             


Thr Thr  Pro Leu Ala Arg Ala  Ala Trp Glu Thr Ala  Arg His Thr 
    2810                 2815                 2820             


Pro Val  Asn Ser Trp Leu Gly  Asn Ile Ile Met Phe  Ala Pro Thr 
    2825                 2830                 2835             


Leu Trp  Ala Arg Met Ile Leu  Met Thr His Phe Phe  Ser Val Leu 
    2840                 2845                 2850             


Ile Ala  Arg Asp Gln Leu Glu  Gln Ala Leu Asn Cys  Glu Ile Tyr 
    2855                 2860                 2865             


Gly Ala  Cys Tyr Ser Ile Glu  Pro Leu Asp Leu Pro  Pro Ile Ile 
    2870                 2875                 2880             


Gln Arg  Leu His Gly Leu Ser  Ala Phe Ser Leu His  Ser Tyr Ser 
    2885                 2890                 2895             


Pro Gly  Glu Ile Asn Arg Val  Ala Ala Cys Leu Arg  Lys Leu Gly 
    2900                 2905                 2910             


Val Pro  Pro Leu Arg Ala Trp  Arg His Arg Ala Arg  Ser Val Arg 
    2915                 2920                 2925             


Ala Arg  Leu Leu Ser Arg Gly  Gly Arg Ala Ala Ile  Cys Gly Lys 
    2930                 2935                 2940             


Tyr Leu  Phe Asn Trp Ala Val  Arg Thr Lys Leu Lys  Leu Thr Pro 
    2945                 2950                 2955             


Ile Thr  Ala Ala Gly Arg Leu  Asp Leu Ser Gly Trp  Phe Thr Ala 
    2960                 2965                 2970             


Gly Tyr  Ser Gly Gly Asp Ile  Tyr His Ser Val Ser  His Ala Arg 
    2975                 2980                 2985             


Pro Arg  Trp Phe Trp Phe Cys  Leu Leu Leu Leu Ala  Ala Gly Val 
    2990                 2995                 3000             


Gly Ile  Tyr Leu Leu Pro Asn  Arg 
    3005                 3010     


