
                                SEQUENCE LISTING

<110> Calmune Corporation
      Williamson, Robert Anthony
      Wadia, Jehangir
      Maruyama, Toshiaki
      Chen, Zhifeng
      Nelson, Joshua

<120> METHODS AND VECTORS FOR DISPLAY OF
  MOLECULES AND DISPLAYED MOLECULES AND COLLECTIONS
  

<130> 119367-00034/1107PC

<140> Not yet assigned
<141> Herewith

<150> 61/192,982
<151> 2008-09-22

<150> 61/192,960
<151> 2008-09-22

<160> 337

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Pel B leader

<400> 1
atgaaatacc tgctgccgac cgcagccgct ggtctgctgc tgctcgcggc ccagccggcc 60
atggccgccg gt                                                     72

<210> 2
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> Pel B leader

<400> 2
Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala
 1               5                  10                  15      
Ala Gln Pro Ala Met Ala Ala Gly
            20                  


<210> 3
<211> 72
<212> DNA
<213> Artificial Sequence

<220> 
<223> Pel B leader amber stop

<400> 3
atgaaatacc tgctgccgac cgcagccgct ggtctgctgc tgctcgcggc ctagccggcc 60
atggccgccg gt                                                     72

<210> 4
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Pel B leader amber stop

<400> 4
Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala
 1               5                  10                  15      
Ala
    


<210> 5
<211> 69
<212> DNA
<213> Artificial Sequence

<220> 
<223> OmpA leader

<400> 5
atgaaaaaga cagctatcgc gattgcagtg gcactggctg gtttcgctac cgtagcccag 60
gcggccgca                                                         69

<210> 6
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> OmpA leader

<400> 6
Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala
 1               5                  10                  15      
Thr Val Ala Gln Ala Ala Ala
            20              


<210> 7
<211> 69
<212> DNA
<213> Artificial Sequence

<220> 
<223> OmpA leader amber stop

<400> 7
atgaaaaaga cagctatcgc gattgcagtg gcactggctg gtttcgctac cgtagcctag 60
gcggccgca                                                         69

<210> 8
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> OmpA leader amber stop

<400> 8
Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala
 1               5                  10                  15      
Thr Val Ala
            


<210> 9
<211> 35
<212> PRT
<213> Artificial Sequence

<220> 
<223> GCN4 zipper
      

<400> 9
Gly Arg Met Lys Gln Leu Glu Asp Lys Val Glu Glu Leu Leu Ser Lys
 1               5                  10                  15      
Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val Gly
            20                  25                  30          
Glu Arg Gly
        35  


<210> 10
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 VH domain
      

<400> 10
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
 1               5                  10                  15      
Ser Leu Ile Leu Ser Cys Gly Val Ser Asn Phe Arg Ile Ser Ala His
            20                  25                  30          
Thr Met Asn Trp Val Arg Arg Val Pro Gly Gly Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Leu Glu Asp Phe Val Tyr
65                  70                  75                  80  
Leu Gln Met His Lys Met Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Gly Ser Asp Arg Leu Ser Asp Asn Asp Pro Phe Asp Ala
            100                 105                 110         
Trp Gly Pro Gly Thr Val Val Thr Val Ser Pro
        115                 120             


<210> 11
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 VL domain 1

<400> 11
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ala Gly Tyr Ser Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys
            100                 105         


<210> 12
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 VL domain 2

<400> 12
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ala Gly Tyr Ser
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys
            100                 105             


<210> 13
<211> 3513
<212> DNA
<213> Artificial Sequence

<220> 
<223> pCAL G13 vector
      

<400> 13
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt 180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt 240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt 300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg 360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga 420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa 480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga 540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa 600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca 660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta 720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac 780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc 840
gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag 900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga 960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt 1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata 1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag 1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa 1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt 1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc 1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa 1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa 1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc 1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa 1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa 1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg 1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc 1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg 1800
ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg 1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg 1920
aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat 1980
gcagctggca cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaatg 2040
tgagttagct cactcattag gcaccccagg ctttacactt tatgcttccg gctcgtatgt 2100
tgtgtggaat tgtgagcgga taacaattga attaaggagg atataattat gaaatacctg 2160
ctgccgaccg cagccgctgg tctgctgctg ctcgcggccc agccggccat ggccgccggt 2220
gcctaactct ggctggtttc gctaccgtaa ccggtttaat taataaggag gatataatta 2280
tgaaaaagac agctatcgcg attgcagtgg cactggctgg tttcgctacc gtagcccagg 2340
cggccgcacg cgtctggttg aatctggtgg ggtctggaat tctgcgatcg cggccaggcc 2400
ggccgcacca tcaccatcac catggcgcat acccgtacga cgttccggac tacgcttcta 2460
ctagttagga gggtggtggc tctgagggtg gcggttctga gggtggcggc tctgagggag 2520
gcggttccgg tggtggctct ggttccggtg attttgatta tgaaaagatg gcaaacgcta 2580
ataagggggc tatgaccgaa aatgccgatg aaaacgcgct acagtctgac gctaaaggca 2640
aacttgattc tgtcgctact gattacggtg ctgctatcga tggtttcatt ggtgacgttt 2700
ccggccttgc taatggtaat ggtgctactg gtgattttgc tggctctaat tcccaaatgg 2760
ctcaagtcgg tgacggtgat aattcacctt taatgaataa tttccgtcaa tatttacctt 2820
ccctccctca atcggttgaa tgtcgccctt ttgtctttgg cgctggtaaa ccatatgaat 2880
tttctattga ttgtgacaaa ataaacttat tccgtggtgt ctttgcgttt cttttatatg 2940
ttgccacctt tatgtatgta ttttctacgt ttgctaacat actgcgtaat aaggagtctt 3000
aagctagcta acgatcgccc ttcccaacag ttgcgcagcc tgaatggcga atgggacgcg 3060
ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca 3120
cttgccagcg ccctagcgcc cgctcctttc gctttcttcc cttcctttct cgccacgttc 3180
gccggctttc cccgtcaagc tctaaatcgg gggctccctt tagggttccg atttagtgct 3240
ttacggcacc tcgaccccaa aaaacttgat tagggtgatg gttcacgtag tgggccatcg 3300
ccctgataga cggtttttcg ccctttgacg ttggagtcca cgttctttaa tagtggactc 3360
ttgttccaaa ctggaacaac actcaaccct atctcggtct attcttttga tttataaggg 3420
attttgccga tttcggccta ttggttaaaa aatgagctga tttaacaaaa atttaacgcg 3480
aattttaaca aaatattaac gcttacaatt tag                              3513

<210> 14
<211> 3513
<212> DNA
<213> Artificial Sequence

<220> 
<223> pCAL A1 vector

<400> 14
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt 180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt 240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt 300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg 360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga 420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa 480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga 540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa 600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca 660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta 720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac 780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc 840
gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag 900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga 960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt 1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata 1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag 1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa 1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt 1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc 1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa 1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa 1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc 1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa 1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa 1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg 1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc 1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg 1800
ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg 1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg 1920
aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat 1980
gcagctggca cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaatg 2040
tgagttagct cactcattag gcaccccagg ctttacactt tatgcttccg gctcgtatgt 2100
tgtgtggaat tgtgagcgga taacaattga attaaggagg atataattat gaaatacctg 2160
ctgccgaccg cagccgctgg tctgctgctg ctcgcggccc agccggccat ggccgccggt 2220
gcctaactct ggctggtttc gctaccgtaa ccggtttaat taataaggag gatataatta 2280
tgaaaaagac agctatcgcg attgcagtgg cactggctgg tttcgctacc gtagcccagg 2340
cggccgcacg cgtctggttg aatctggtgg ggtctggaat tctgcgatcg cggccaggcc 2400
ggccgcacca tcaccatcac catggcgcat acccgtacga cgttccggac tacgcttcta 2460
ctagttagaa gggtggtggc tctgagggtg gcggttctga gggtggcggc tctgagggag 2520
gcggttccgg tggtggctct ggttccggtg attttgatta tgaaaagatg gcaaacgcta 2580
ataagggggc tatgaccgaa aatgccgatg aaaacgcgct acagtctgac gctaaaggca 2640
aacttgattc tgtcgctact gattacggtg ctgctatcga tggtttcatt ggtgacgttt 2700
ccggccttgc taatggtaat ggtgctactg gtgattttgc tggctctaat tcccaaatgg 2760
ctcaagtcgg tgacggtgat aattcacctt taatgaataa tttccgtcaa tatttacctt 2820
ccctccctca atcggttgaa tgtcgccctt ttgtctttgg cgctggtaaa ccatatgaat 2880
tttctattga ttgtgacaaa ataaacttat tccgtggtgt ctttgcgttt cttttatatg 2940
ttgccacctt tatgtatgta ttttctacgt ttgctaacat actgcgtaat aaggagtctt 3000
aagctagcta acgatcgccc ttcccaacag ttgcgcagcc tgaatggcga atgggacgcg 3060
ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca 3120
cttgccagcg ccctagcgcc cgctcctttc gctttcttcc cttcctttct cgccacgttc 3180
gccggctttc cccgtcaagc tctaaatcgg gggctccctt tagggttccg atttagtgct 3240
ttacggcacc tcgaccccaa aaaacttgat tagggtgatg gttcacgtag tgggccatcg 3300
ccctgataga cggtttttcg ccctttgacg ttggagtcca cgttctttaa tagtggactc 3360
ttgttccaaa ctggaacaac actcaaccct atctcggtct attcttttga tttataaggg 3420
attttgccga tttcggccta ttggttaaaa aatgagctga tttaacaaaa atttaacgcg 3480
aattttaaca aaatattaac gcttacaatt tag                              3513

<210> 15
<211> 54
<212> DNA
<213> Artificial Sequence

<220> 
<223> Linker 1

<400> 15
ggtggttcgt ctggatcttc ctcctctggt ggcggtggct cgggcggtgg tggc       54

<210> 16
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 1

<400> 16
Gly Gly Ser Ser Gly Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly
 1               5                  10                  15      
Gly Gly
        


<210> 17
<211> 54
<212> DNA
<213> Artificial Sequence

<220> 
<223> Linker 2

<400> 17
ggaggatccg gcagcagcag cagcggcggc ggcggcggga gctccggcgg cgga       54

<210> 18
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker 2

<400> 18
Gly Gly Ser Gly Ser Ser Ser Ser Gly Gly Gly Gly Gly Ser Ser Gly
 1               5                  10                  15      
Gly Gly
        


<210> 19
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> L216

<400> 19
ggaggatccg gcagcagcag cagcggcggc gggagctccg gcggcgga              48

<210> 20
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> L216

<400> 20
Gly Gly Ser Gly Ser Ser Ser Ser Gly Gly Gly Ser Ser Gly Gly Gly
 1               5                  10                  15      


<210> 21
<211> 51
<212> DNA
<213> Artificial Sequence

<220> 
<223> L217

<400> 21
ggaggatccg gcagcagcag cagcggcggc ggcgggagct ccggcggcgg a          51

<210> 22
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> L217

<400> 22
Gly Gly Ser Gly Ser Ser Ser Ser Gly Gly Gly Gly Ser Ser Gly Gly
 1               5                  10                  15      
Gly
    


<210> 23
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> L219

<400> 23
ggaggatcca gcggcagcag cagcagcggc ggcggcggcg ggagctccgg cggcgga    57

<210> 24
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> L219

<400> 24
Gly Gly Ser Ser Gly Ser Ser Ser Ser Gly Gly Gly Gly Gly Ser Ser
 1               5                  10                  15      
Gly Gly Gly
            


<210> 25
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> L220

<400> 25
ggaggatcca gcggcggcag cagcagcagc ggcggcggcg gcgggagctc cggcggcgga 60


<210> 26
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> L220

<400> 26
Gly Gly Ser Ser Gly Gly Ser Ser Ser Ser Gly Gly Gly Gly Gly Ser
 1               5                  10                  15      
Ser Gly Gly Gly
            20  


<210> 27
<211> 87
<212> DNA
<213> Artificial Sequence

<220> 
<223> BamHISacI linker / BamHISacI(+)

<400> 27
gatccggtgg cggcagcgaa ggtggtggca gcgaaggtgg cggtagcgaa ggtggcggca 60
gcgaaggcgg cggtagcggt gggagct                                     87

<210> 28
<211> 29
<212> PRT
<213> Artificial Sequence

<220> 
<223> BamHISacI linker
      

<400> 28
Asp Pro Val Ala Ala Ala Lys Val Val Ala Ala Lys Val Ala Val Ala
 1               5                  10                  15      
Lys Val Ala Ala Ala Lys Ala Ala Val Ala Val Gly Ala
            20                  25                  


<210> 29
<211> 6819
<212> DNA
<213> Artificial Sequence

<220> 
<223> vector with 2G12 Fab Cys19 construct

<400> 29
ggggaattgt gagcggataa caattcccct ctagaaataa ttttgtttaa ctttaagaag 60
gagatatacc atgaaaaaga cagctatcgc gattgcagtg gcactggctg gtttcgctac 120
cgtggcccag gcggccgttg ttatgaccca gtctccgtct accctgtctg cttctgttgg 180
tgacaccatc accatcacct gccgtgcttc tcagtctatc gaaacctggc tggcttggta 240
ccagcagaaa ccgggtaaag ctccgaaact gctgatctac aaggcttcta ccctgaaaac 300
cggtgttccg tctcgtttct ctggttctgg ttctggtacc gagttcaccc tgaccatctc 360
tggtctgcag ttcgacgact tcgctaccta ccactgccag cactacgctg gttactctgc 420
taccttcggt cagggtaccc gtgttgaaat caaacgtacc gttgctgctc cgtctgtttt 480
catcttcccg ccgtctgacg aacagctgaa atctggtacc gcttctgttg tttgcctgct 540
gaacaacttc tacccgcgtg aagctaaagt tcagtggaaa gttgacaacg ctctgcagtc 600
tggtaactct caggaatctg ttaccgaaca ggactctaaa gactctacct actctctgtc 660
ttctaccctg accctgtcta aagctgacta cgaaaagcac aaagtttacg cttgcgaagt 720
tacccaccag ggtctgtctt ctccggttac caaatctttc aaccgtggtg aatgctaggg 780
ccaggccggc cgcggccgca taatgcttaa gtcgaacaga aagtaatcgt attgtacacg 840
gccgcataat cgaaattaat acgactcact ataggggaat tgtgagcgga taacaattcc 900
ccatcttagt atattagtta agtataagaa ggagatatac atatgaaata cctattgcct 960
acggcagccg ctggattgtt attactcgct gcccaaccag ccatggccga agttcagctg 1020
gttgaatctg gtggtggtct ggttaaagct ggtggttctc tgtgcctgtc ttgcggtgtt 1080
tctaacttcc gtatctctgc tcacaccatg aactgggttc gtcgtgttcc gggtggtggt 1140
ctggaatggg ttgcttctat ctctacctct tctacctacc gtgactacgc tgacgctgtt 1200
aaaggtcgtt tcaccgtttc tcgtgacgac ctggaagact tcgtttacct gcagatgcat 1260
aaaatgcgtg ttgaagacac cgctatctac tactgcgctc gtaaaggttc tgaccgtctg 1320
tctgacaacg acccgttcga cgcttggggt ccgggtaccg ttgttaccgt ttctccggcg 1380
tcgaccaaag gtccgtctgt tttcccgctg gctccgtctt ctaaatctac ctctggtggt 1440
accgctgctc tgggttgcct ggttaaagac tacttcccgg aaccggttac cgtttcttgg 1500
aactctggtg ctctgacctc tggtgttcac accttcccgg ctgttctgca gtcttctggt 1560
ctgtactctc tgtcttctgt tgttaccgtt ccgtcttctt ctctgggtac ccagacctac 1620
atctgcaacg ttaaccacaa accgtctaac accaaagttg acaagaaagt tgaaccgaaa 1680
tcttgcggca gcagccacca tcaccatcac catggcgcat acccgtacga cgttccggac 1740
tacgcttctt agctcgagtc tggtaaagaa accgctgctg cgaaatttga acgccagcac 1800
atggactcgt ctactagcgc agcttaatta acctaggctg ctgccaccgc tgagcaataa 1860
ctagcataac cccttggggc ctctaaacgg gtcttgaggg gttttttgct gaaaggagga 1920
actatatccg gattggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg 1980
tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg 2040
ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg 2100
ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt 2160
agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt 2220
tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta 2280
tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa 2340
atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg tttacaattt 2400
ctggcggcac gatggcatga gattatcaaa aaggatcttc acctagatcc ttttaaatta 2460
aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa acttggtctg acagttacca 2520
atgcttaatc agtgaggcac ctatctcagc gatctgtcta tttcgttcat ccatagttgc 2580
ctgactcccc gtcgtgtaga taactacgat acgggagggc ttaccatctg gccccagtgc 2640
tgcaatgata ccgcgagacc cacgctcacc ggctccagat ttatcagcaa taaaccagcc 2700
agccggaagg gccgagcgca gaagtggtcc tgcaacttta tccgcctcca tccagtctat 2760
taattgttgc cgggaagcta gagtaagtag ttcgccagtt aatagtttgc gcaacgttgt 2820
tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt cattcagctc 2880
cggttcccaa cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa aagcggttag 2940
ctccttcggt cctccgatcg ttgtcagaag taagttggcc gcagtgttat cactcatggt 3000
tatggcagca ctgcataatt ctcttactgt catgccatcc gtaagatgct tttctgtgac 3060
tggtgagtac tcaaccaagt cattctgaga atagtgtatg cggcgaccga gttgctcttg 3120
cccggcgtca atacgggata ataccgcgcc acatagcaga actttaaaag tgctcatcat 3180
tggaaaacgt tcttcggggc gaaaactctc aaggatctta ccgctgttga gatccagttc 3240
gatgtaaccc actcgtgcac ccaactgatc ttcagcatct tttactttca ccagcgtttc 3300
tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg cgacacggaa 3360
atgttgaata ctcatactct tcctttttca atcatgattg aagcatttat cagggttatt 3420
gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata ggtcatgacc 3480
aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa 3540
ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca 3600
ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta 3660
actggcttca gcagagcgca gataccaaat actgtccttc tagtgtagcc gtagttaggc 3720
caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca 3780
gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta 3840
ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag 3900
cgaacgacct acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt 3960
cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc 4020
acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac 4080
ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac 4140
gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgttc 4200
tttcctgcgt tatcccctga ttctgtggat aaccgtatta ccgcctttga gtgagctgat 4260
accgctcgcc gcagccgaac gaccgagcgc agcgagtcag tgagcgagga agcggaagag 4320
cgcctgatgc ggtattttct ccttacgcat ctgtgcggta tttcacaccg catatatggt 4380
gcactctcag tacaatctgc tctgatgccg catagttaag ccagtataca ctccgctatc 4440
gctacgtgac tgggtcatgg ctgcgccccg acacccgcca acacccgctg acgcgccctg 4500
acgggcttgt ctgctcccgg catccgctta cagacaagct gtgaccgtct ccgggagctg 4560
catgtgtcag aggttttcac cgtcatcacc gaaacgcgcg aggcagctgc ggtaaagctc 4620
atcagcgtgg tcgtgaagcg attcacagat gtctgcctgt tcatccgcgt ccagctcgtt 4680
gagtttctcc agaagcgtta atgtctggct tctgataaag cgggccatgt taagggcggt 4740
tttttcctgt ttggtcactg atgcctccgt gtaaggggga tttctgttca tgggggtaat 4800
gataccgatg aaacgagaga ggatgctcac gatacgggtt actgatgatg aacatgcccg 4860
gttactggaa cgttgtgagg gtaaacaact ggcggtatgg atgcggcggg accagagaaa 4920
aatcactcag ggtcaatgcc agcgcttcgt taatacagat gtaggtgttc cacagggtag 4980
ccagcagcat cctgcgatgc agatccggaa cataatggtg cagggcgctg acttccgcgt 5040
ttccagactt tacgaaacac ggaaaccgaa gaccattcat gttgttgctc aggtcgcaga 5100
cgttttgcag cagcagtcgc ttcacgttcg ctcgcgtatc ggtgattcat tctgctaacc 5160
agtaaggcaa ccccgccagc ctagccgggt cctcaacgac aggagcacga tcatgctagt 5220
catgccccgc gcccaccgga aggagctgac tgggttgaag gctctcaagg gcatcggtcg 5280
agatcccggt gcctaatgag tgagctaact tacattaatt gcgttgcgct cactgcccgc 5340
tttccagtcg ggaaacctgt cgtgccagct gcattaatga atcggccaac gcgcggggag 5400
aggcggtttg cgtattgggc gccagggtgg tttttctttt caccagtgag acgggcaaca 5460
gctgattgcc cttcaccgcc tggccctgag agagttgcag caagcggtcc acgctggttt 5520
gccccagcag gcgaaaatcc tgtttgatgg tggttaacgg cgggatataa catgagctgt 5580
cttcggtatc gtcgtatccc actaccgaga tgtccgcacc aacgcgcagc ccggactcgg 5640
taatggcgcg cattgcgccc agcgccatct gatcgttggc aaccagcatc gcagtgggaa 5700
cgatgccctc attcagcatt tgcatggttt gttgaaaacc ggacatggca ctccagtcgc 5760
cttcccgttc cgctatcggc tgaatttgat tgcgagtgag atatttatgc cagccagcca 5820
gacgcagacg cgccgagaca gaacttaatg ggcccgctaa cagcgcgatt tgctggtgac 5880
ccaatgcgac cagatgctcc acgcccagtc gcgtaccgtc ttcatgggag aaaataatac 5940
tgttgatggg tgtctggtca gagacatcaa gaaataacgc cggaacatta gtgcaggcag 6000
cttccacagc aatggcatcc tggtcatcca gcggatagtt aatgatcagc ccactgacgc 6060
gttgcgcgag aagattgtgc accgccgctt tacaggcttc gacgccgctt cgttctacca 6120
tcgacaccac cacgctggca cccagttgat cggcgcgaga tttaatcgcc gcgacaattt 6180
gcgacggcgc gtgcagggcc agactggagg tggcaacgcc aatcagcaac gactgtttgc 6240
ccgccagttg ttgtgccacg cggttgggaa tgtaattcag ctccgccatc gccgcttcca 6300
ctttttcccg cgttttcgca gaaacgtggc tggcctggtt caccacgcgg gaaacggtct 6360
gataagagac accggcatac tctgcgacat cgtataacgt tactggtttc acattcacca 6420
ccctgaattg actctcttcc gggcgctatc atgccatacc gcgaaaggtt ttgcgccatt 6480
cgatggtgtc cgggatctcg acgctctccc ttatgcgact cctgcattag gaagcagccc 6540
agtagtaggt tgaggccgtt gagcaccgcc gccgcaagga atggtgcatg caaggagatg 6600
gcgcccaaca gtcccccggc cacggggcct gccaccatac ccacgccgaa acaagcgctc 6660
atgagcccga agtggcgagc ccgatcttcc ccatcggtga tgtcggcgat ataggcgcca 6720
gcaaccgcac ctgtggcgcc ggtgatgccg gccacgatgc gtccggcgta gaggatcgag 6780
atcgatctcg atcccgcgaa attaatacga ctcactata                        6819


<210> 30
<211> 6802
<212> DNA
<213> Artificial Sequence

<220> 
<223> vector with 2G12 scFab deltaC2Cys19 construct

<400> 30
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg 60
cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc 120
ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg 180
gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc 240
acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt 300
ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc 360
ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta 420
acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt 480
tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta 540
tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat 600
tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa 660
actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc 720
gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga 780
aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc 840
agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac 900
cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac 960
aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatat 1020
tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag 1080
tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca 1140
taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac 1200
ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg 1260
tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca 1320
tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac 1380
cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa 1440
cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga 1500
gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg 1560
gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc 1620
agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag 1680
aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc 1740
agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg 1800
cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac 1860
accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga 1920
aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt 1980
ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag 2040
cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg 2100
gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta 2160
tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc 2220
agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg 2280
tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta 2340
caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg 2400
ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct 2460
gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag 2520
gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc 2580
gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag 2640
aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt 2700
ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa 2760
acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg 2820
ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg 2880
tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc 2940
tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta 3000
cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca 3060
gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc 3120
ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc 3180
catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa 3240
ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc 3300
gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac 3360
gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca 3420
ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta 3480
atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa 3540
cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat 3600
tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca 3660
ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa 3720
aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt 3780
atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg 3840
cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca 3900
gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta 3960
tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg 4020
agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat 4080
gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct 4140
ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg 4200
catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat 4260
tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc 4320
tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca 4380
gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg 4440
ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt 4500
tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg 4560
catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct 4620
cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga 4680
tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg 4740
ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc 4800
ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg 4860
cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg 4920
gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc gatcccgcga 4980
aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagaaataa 5040
ttttgtttaa ctttaagaag gagatatacc atgaaaaaga cagctatcgc gattgcagtg 5100
gcactggctg gtttcgctac cgtggcccag gcggccgttg ttatgaccca gtctccgtct 5160
accctgtctg cttctgttgg tgacaccatc accatcacct gccgtgcttc tcagtctatc 5220
gaaacctggc tggcttggta ccagcagaaa ccgggtaaag ctccgaaact gctgatctac 5280
aaggcttcta ccctgaaaac cggtgttccg tctcgtttct ctggttctgg ttctggtacc 5340
gagttcaccc tgaccatctc tggtctgcag ttcgacgact tcgctaccta ccactgccag 5400
cactacgctg gttactctgc taccttcggt cagggtaccc gtgttgaaat caaacgtacc 5460
gttgctgctc cgtctgtttt catcttcccg ccgtctgacg aacagctgaa atctggtacc 5520
gcttctgttg tttgcctgct gaacaacttc tacccgcgtg aagctaaagt tcagtggaaa 5580
gttgacaacg ctctgcagtc tggtaactct caggaatctg ttaccgaaca ggactctaaa 5640
gactctacct actctctgtc ttctaccctg accctgtcta aagctgacta cgaaaagcac 5700
aaagtttacg cttgcgaagt tacccaccag ggtctgtctt ctccggttac caaatctttc 5760
aaccgtggtg aatctggtgg tggatccggt ggcggcagcg aaggtggtgg cagcgaaggt 5820
ggcggtagcg aaggtggcgg cagcgaaggc ggcggtagcg gtgggagctc cggtgaagtt 5880
cagctggttg aatctggtgg tggtctggtt aaagctggtg gttctctgtg cctgtcttgc 5940
ggtgtttcta acttccgtat ctctgctcac accatgaact gggttcgtcg tgttccgggt 6000
ggtggtctgg aatgggttgc ttctatctct acctcttcta cctaccgtga ctacgctgac 6060
gctgttaaag gtcgtttcac cgtttctcgt gacgacctgg aagacttcgt ttacctgcag 6120
atgcacaaaa tgcgtgttga agacaccgct atctactact gcgctcgtaa aggttctgac 6180
cgtctgtctg acaacgaccc gttcgacgct tggggtccgg gtaccgttgt taccgtttct 6240
ccggcgtcga ccaaaggtcc gtctgttttc ccgctggctc cgtcttctaa atctacctct 6300
ggtggtaccg ctgctctggg ttgcctggtt aaagactact tcccggaacc ggttaccgtt 6360
tcttggaact ctggtgctct gacctctggt gttcacacct tcccggctgt tctgcagtct 6420
tctggtctgt actctctgtc ttctgttgtt accgttccgt cttcttctct gggtacccag 6480
acctacatct gcaacgttaa ccacaaaccg tctaacacca aagttgacaa gaaagttgaa 6540
ccgaaatctg gcagcagcgg ccaggccggc cagcaccatc accatcacca tggcgcatac 6600
ccgtacgacg ttccggacta cgcttcttag gcggccgcac tcgagcacca ccaccaccac 6660
cactgagatc cggctgctaa caaagcccga aaggaagctg agttggctgc tgccaccgct 6720
gagcaataac tagcataacc ccttggggcc tctaaacggg tcttgagggg ttttttgctg 6780
aaaggaggaa ctatatccgg at                                          6802


<210> 31
<211> 6121
<212> DNA
<213> Artificial Sequence

<220> 
<223> vector with 2G12 scFv Cys19 construct

<400> 31
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg 60
cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc 120
ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg 180
gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc 240
acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt 300
ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc 360
ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta 420
acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt 480
tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta 540
tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat 600
tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa 660
actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc 720
gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga 780
aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc 840
agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac 900
cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac 960
aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatat 1020
tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag 1080
tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca 1140
taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac 1200
ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg 1260
tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca 1320
tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac 1380
cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa 1440
cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga 1500
gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg 1560
gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc 1620
agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag 1680
aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc 1740
agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg 1800
cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac 1860
accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga 1920
aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt 1980
ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag 2040
cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg 2100
gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta 2160
tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc 2220
agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg 2280
tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta 2340
caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg 2400
ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct 2460
gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag 2520
gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc 2580
gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag 2640
aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt 2700
ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa 2760
acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg 2820
ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg 2880
tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc 2940
tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta 3000
cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca 3060
gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc 3120
ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc 3180
catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa 3240
ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc 3300
gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac 3360
gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca 3420
ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta 3480
atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa 3540
cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat 3600
tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca 3660
ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa 3720
aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt 3780
atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg 3840
cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca 3900
gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta 3960
tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg 4020
agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat 4080
gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct 4140
ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg 4200
catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat 4260
tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc 4320
tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca 4380
gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg 4440
ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt 4500
tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg 4560
catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct 4620
cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga 4680
tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg 4740
ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc 4800
ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg 4860
cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg 4920
gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc gatcccgcga 4980
aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagaaataa 5040
ttttgtttaa ctttaagaag gagatatacc atgaaaaaga cagctatcgc gattgcagtg 5100
gcactggctg gtttcgctac cgtggcccag gcggccgttg ttatgaccca gtctccgtct 5160
accctgtctg cttctgttgg tgacaccatc accatcacct gccgtgcttc tcagtctatc 5220
gaaacctggc tggcttggta ccagcagaaa ccgggtaaag ctccgaaact gctgatctac 5280
aaggcttcta ccctgaaaac cggtgttccg tctcgtttct ctggttctgg ttctggtacc 5340
gagttcaccc tgaccatctc tggtctgcag ttcgacgact tcgctaccta ccactgccag 5400
cactacgctg gttactctgc taccttcggt cagggtaccc gtgttgaaat caaaggtggt 5460
tcgtctggat cttcctcctc tggtggcggt ggctcgggcg gtggtggcga agttcagctg 5520
gttgaatctg gtggtggtct ggttaaagct ggtggttctc tgtgcctgtc ttgcggtgtt 5580
tctaacttcc gtatctctgc tcacaccatg aactgggttc gtcgtgttcc gggtggtggt 5640
ctggaatggg ttgcttctat ctctacctct tctacctacc gtgactacgc tgacgctgtt 5700
aaaggtcgtt tcaccgtttc tcgtgacgac ctggaagact tcgtttacct gcagatgcac 5760
aaaatgcgtg ttgaagacac cgctatctac tactgcgctc gtaaaggttc tgaccgtctg 5820
tctgacaacg acccgttcga cgcttggggt ccgggtaccg ttgttaccgt ttctccgggc 5880
caggccggcc agcaccatca ccatcaccat ggcgcatacc cgtacgacgt tccggactac 5940
gcttcttagg cggccgcact cgagcaccac caccaccacc actgagatcc ggctgctaac 6000
aaagcccgaa aggaagctga gttggctgct gccaccgctg agcaataact agcataaccc 6060
cttggggcct ctaaacgggt cttgaggggt tttttgctga aaggaggaac tatatccgga 6120
t                                                                 6121


<210> 32
<211> 4765
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 pCAL G13 vector

<400> 32
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt 180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt 240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt 300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg 360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga 420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa 480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga 540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa 600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca 660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta 720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac 780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc 840
gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag 900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga 960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt 1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata 1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag 1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa 1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt 1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc 1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa 1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa 1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc 1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa 1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa 1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg 1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc 1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg 1800
ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg 1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg 1920
aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat 1980
gcagctggca cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaatg 2040
tgagttagct cactcattag gcaccccagg ctttacactt tatgcttccg gctcgtatgt 2100
tgtgtggaat tgtgagcgga taacaattga attaaggagg atataattat gaaatacctg 2160
ctgccgaccg cagccgctgg tctgctgctg ctcgcggccc agccggccat ggccgccggt 2220
gttgttatga cccagtctcc gtctaccctg tctgcttctg ttggtgacac catcaccatc 2280
acctgccgtg cttctcagtc tatcgaaacc tggctggctt ggtaccagca gaaaccgggt 2340
aaagctccga aactgctgat ctacaaggct tctaccctga aaaccggtgt tccgtctcgt 2400
ttctctggtt ctggttctgg taccgagttc accctgacca tctctggtct gcagttcgac 2460
gacttcgcta cctaccactg ccagcactac gctggttact ctgctacctt cggtcagggt 2520
acccgtgttg aaatcaaacg taccgttgct gctccgtctg ttttcatctt cccgccgtct 2580
gacgaacagc tgaaatctgg taccgcttct gttgtttgcc tgctgaacaa cttctacccg 2640
cgtgaagcta aagttcagtg gaaagttgac aacgctctgc agtctggtaa ctctcaggaa 2700
tctgttaccg aacaggactc taaagactct acctactctc tgtcttctac cctgaccctg 2760
tctaaagctg actacgaaaa gcacaaagtt tacgcttgcg aagttaccca ccagggtctg 2820
tcttctccgg ttaccaaatc tttcaaccgt ggtgaatgct aattaattaa taaggaggat 2880
ataattatga aaaagacagc tatcgcgatt gcagtggcac tggctggttt cgctaccgta 2940
gcccaggcgg ccgcagaagt tcagctggtt gaatctggtg gtggtctggt taaagctggt 3000
ggttctctga tcctgtcttg cggtgtttct aacttccgta tctctgctca caccatgaac 3060
tgggttcgtc gtgttccggg tggtggtctg gaatgggttg cttctatctc tacctcttct 3120
acctaccgtg actacgctga cgctgttaaa ggtcgtttca ccgtttctcg tgacgacctg 3180
gaagacttcg tttacctgca gatgcataaa atgcgtgttg aagacaccgc tatctactac 3240
tgcgctcgta aaggttctga ccgtctgtct gacaacgacc cgttcgacgc ttggggtccg 3300
ggtaccgttg ttaccgtttc tccggcgtcg accaaaggtc cgtctgtttt cccgctggct 3360
ccgtcttcta aatctacctc tggtggtacc gctgctctgg gttgcctggt taaagactac 3420
ttcccggaac cggttaccgt ttcttggaac tctggtgctc tgacctctgg tgttcacacc 3480
ttcccggctg ttctgcagtc ttctggtctg tactctctgt cttctgttgt taccgttccg 3540
tcttcttctc tgggtaccca gacctacatc tgcaacgtta accacaaacc gtctaacacc 3600
aaagttgaca agaaagttga accgaaatct tgcctgcgat cgcggccagg ccggccgcac 3660
catcaccatc accatggcgc atacccgtac gacgttccgg actacgcttc tactagttag 3720
gagggtggtg gctctgaggg tggcggttct gagggtggcg gctctgaggg aggcggttcc 3780
ggtggtggct ctggttccgg tgattttgat tatgaaaaga tggcaaacgc taataagggg 3840
gctatgaccg aaaatgccga tgaaaacgcg ctacagtctg acgctaaagg caaacttgat 3900
tctgtcgcta ctgattacgg tgctgctatc gatggtttca ttggtgacgt ttccggcctt 3960
gctaatggta atggtgctac tggtgatttt gctggctcta attcccaaat ggctcaagtc 4020
ggtgacggtg ataattcacc tttaatgaat aatttccgtc aatatttacc ttccctccct 4080
caatcggttg aatgtcgccc ttttgtcttt ggcgctggta aaccatatga attttctatt 4140
gattgtgaca aaataaactt attccgtggt gtctttgcgt ttcttttata tgttgccacc 4200
tttatgtatg tattttctac gtttgctaac atactgcgta ataaggagtc ttaagctagc 4260
taacgatcgc ccttcccaac agttgcgcag cctgaatggc gaatgggacg cgccctgtag 4320
cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag 4380
cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt 4440
tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca 4500
cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata 4560
gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca 4620
aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc 4680
gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattttaa 4740
caaaatatta acgcttacaa tttag                                       4765

<210> 33
<211> 4765
<212> DNA
<213> Artificial Sequence

<220> 
<223> 3-ALA 2G12 pCAL G13 vector

<400> 33
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt 180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt 240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt 300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg 360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga 420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa 480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga 540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa 600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca 660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta 720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac 780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc 840
gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag 900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga 960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt 1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata 1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag 1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa 1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt 1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc 1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa 1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa 1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc 1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa 1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa 1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg 1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc 1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg 1800
ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg 1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg 1920
aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat 1980
gcagctggca cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaatg 2040
tgagttagct cactcattag gcaccccagg ctttacactt tatgcttccg gctcgtatgt 2100
tgtgtggaat tgtgagcgga taacaattga attaaggagg atataattat gaaatacctg 2160
ctgccgaccg cagccgctgg tctgctgctg ctcgcggccc agccggccat ggccgccggt 2220
gttgttatga cccagtctcc gtctaccctg tctgcttctg ttggtgacac catcaccatc 2280
acctgccgtg cttctcagtc tatcgaaacc tggctggctt ggtaccagca gaaaccgggt 2340
aaagctccga aactgctgat ctacaaggct tctaccctga aaaccggtgt tccgtctcgt 2400
ttctctggtt ctggttctgg taccgagttc accctgacca tctctggtct gcagttcgac 2460
gacttcgcta cctaccactg ccagcactac gctggttact ctgctacctt cggtcagggt 2520
acccgtgttg aaatcaaacg taccgttgct gctccgtctg ttttcatctt cccgccgtct 2580
gacgaacagc tgaaatctgg taccgcttct gttgtttgcc tgctgaacaa cttctacccg 2640
cgtgaagcta aagttcagtg gaaagttgac aacgctctgc agtctggtaa ctctcaggaa 2700
tctgttaccg aacaggactc taaagactct acctactctc tgtcttctac cctgaccctg 2760
tctaaagctg actacgaaaa gcacaaagtt tacgcttgcg aagttaccca ccagggtctg 2820
tcttctccgg ttaccaaatc tttcaaccgt ggtgaatgct aattaattaa taaggaggat 2880
ataattatga aaaagacagc tatcgcgatt gcagtggcac tggctggttt cgctaccgta 2940
gcccaggcgg ccgcagaagt tcagctggtt gaatctggtg gtggtctggt taaagctggt 3000
ggttctctga tcctgtcttg cggtgtttct aacttccgta tctctgctca caccatgaac 3060
tgggttcgtc gtgttccggg tggtggtctg gaatgggttg cttctatctc tacctcttct 3120
acctaccgtg actacgctga cgctgttaaa ggtcgtttca ccgtttctcg tgacgacctg 3180
gaagacttcg tttacctgca gatgcataaa atgcgtgttg aagacaccgc tatctactac 3240
tgcgctcgta aaggttctga ccgtgcggcg gacgcggacc cgttcgacgc ttggggtccg 3300
ggtaccgttg ttaccgtttc tccggcgtcg accaaaggtc cgtctgtttt cccgctggct 3360
ccgtcttcta aatctacctc tggtggtacc gctgctctgg gttgcctggt taaagactac 3420
ttcccggaac cggttaccgt ttcttggaac tctggtgctc tgacctctgg tgttcacacc 3480
ttcccggctg ttctgcagtc ttctggtctg tactctctgt cttctgttgt taccgttccg 3540
tcttcttctc tgggtaccca gacctacatc tgcaacgtta accacaaacc gtctaacacc 3600
aaagttgaca agaaagttga accgaaatct tgcctgcgat cgcggccagg ccggccgcac 3660
catcaccatc accatggcgc atacccgtac gacgttccgg actacgcttc tactagttag 3720
gagggtggtg gctctgaggg tggcggttct gagggtggcg gctctgaggg aggcggttcc 3780
ggtggtggct ctggttccgg tgattttgat tatgaaaaga tggcaaacgc taataagggg 3840
gctatgaccg aaaatgccga tgaaaacgcg ctacagtctg acgctaaagg caaacttgat 3900
tctgtcgcta ctgattacgg tgctgctatc gatggtttca ttggtgacgt ttccggcctt 3960
gctaatggta atggtgctac tggtgatttt gctggctcta attcccaaat ggctcaagtc 4020
ggtgacggtg ataattcacc tttaatgaat aatttccgtc aatatttacc ttccctccct 4080
caatcggttg aatgtcgccc ttttgtcttt ggcgctggta aaccatatga attttctatt 4140
gattgtgaca aaataaactt attccgtggt gtctttgcgt ttcttttata tgttgccacc 4200
tttatgtatg tattttctac gtttgctaac atactgcgta ataaggagtc ttaagctagc 4260
taacgatcgc ccttcccaac agttgcgcag cctgaatggc gaatgggacg cgccctgtag 4320
cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag 4380
cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt 4440
tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca 4500
cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata 4560
gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca 4620
aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc 4680
gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattttaa 4740
caaaatatta acgcttacaa tttag                                       4765

<210> 34
<211> 4765
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 pCAL A1 vector

<400> 34
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt 180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt 240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt 300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg 360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga 420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa 480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga 540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa 600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca 660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta 720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac 780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc 840
gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag 900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga 960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt 1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata 1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag 1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa 1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt 1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc 1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa 1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa 1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc 1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa 1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa 1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg 1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc 1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg 1800
ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg 1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg 1920
aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat 1980
gcagctggca cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaatg 2040
tgagttagct cactcattag gcaccccagg ctttacactt tatgcttccg gctcgtatgt 2100
tgtgtggaat tgtgagcgga taacaattga attaaggagg atataattat gaaatacctg 2160
ctgccgaccg cagccgctgg tctgctgctg ctcgcggccc agccggccat ggccgccggt 2220
gttgttatga cccagtctcc gtctaccctg tctgcttctg ttggtgacac catcaccatc 2280
acctgccgtg cttctcagtc tatcgaaacc tggctggctt ggtaccagca gaaaccgggt 2340
aaagctccga aactgctgat ctacaaggct tctaccctga aaaccggtgt tccgtctcgt 2400
ttctctggtt ctggttctgg taccgagttc accctgacca tctctggtct gcagttcgac 2460
gacttcgcta cctaccactg ccagcactac gctggttact ctgctacctt cggtcagggt 2520
acccgtgttg aaatcaaacg taccgttgct gctccgtctg ttttcatctt cccgccgtct 2580
gacgaacagc tgaaatctgg taccgcttct gttgtttgcc tgctgaacaa cttctacccg 2640
cgtgaagcta aagttcagtg gaaagttgac aacgctctgc agtctggtaa ctctcaggaa 2700
tctgttaccg aacaggactc taaagactct acctactctc tgtcttctac cctgaccctg 2760
tctaaagctg actacgaaaa gcacaaagtt tacgcttgcg aagttaccca ccagggtctg 2820
tcttctccgg ttaccaaatc tttcaaccgt ggtgaatgct aattaattaa taaggaggat 2880
ataattatga aaaagacagc tatcgcgatt gcagtggcac tggctggttt cgctaccgta 2940
gcccaggcgg ccgcagaagt tcagctggtt gaatctggtg gtggtctggt taaagctggt 3000
ggttctctga tcctgtcttg cggtgtttct aacttccgta tctctgctca caccatgaac 3060
tgggttcgtc gtgttccggg tggtggtctg gaatgggttg cttctatctc tacctcttct 3120
acctaccgtg actacgctga cgctgttaaa ggtcgtttca ccgtttctcg tgacgacctg 3180
gaagacttcg tttacctgca gatgcataaa atgcgtgttg aagacaccgc tatctactac 3240
tgcgctcgta aaggttctga ccgtctgtct gacaacgacc cgttcgacgc ttggggtccg 3300
ggtaccgttg ttaccgtttc tccggcgtcg accaaaggtc cgtctgtttt cccgctggct 3360
ccgtcttcta aatctacctc tggtggtacc gctgctctgg gttgcctggt taaagactac 3420
ttcccggaac cggttaccgt ttcttggaac tctggtgctc tgacctctgg tgttcacacc 3480
ttcccggctg ttctgcagtc ttctggtctg tactctctgt cttctgttgt taccgttccg 3540
tcttcttctc tgggtaccca gacctacatc tgcaacgtta accacaaacc gtctaacacc 3600
aaagttgaca agaaagttga accgaaatct tgcctgcgat cgcggccagg ccggccgcac 3660
catcaccatc accatggcgc atacccgtac gacgttccgg actacgcttc tactagttag 3720
aagggtggtg gctctgaggg tggcggttct gagggtggcg gctctgaggg aggcggttcc 3780
ggtggtggct ctggttccgg tgattttgat tatgaaaaga tggcaaacgc taataagggg 3840
gctatgaccg aaaatgccga tgaaaacgcg ctacagtctg acgctaaagg caaacttgat 3900
tctgtcgcta ctgattacgg tgctgctatc gatggtttca ttggtgacgt ttccggcctt 3960
gctaatggta atggtgctac tggtgatttt gctggctcta attcccaaat ggctcaagtc 4020
ggtgacggtg ataattcacc tttaatgaat aatttccgtc aatatttacc ttccctccct 4080
caatcggttg aatgtcgccc ttttgtcttt ggcgctggta aaccatatga attttctatt 4140
gattgtgaca aaataaactt attccgtggt gtctttgcgt ttcttttata tgttgccacc 4200
tttatgtatg tattttctac gtttgctaac atactgcgta ataaggagtc ttaagctagc 4260
taacgatcgc ccttcccaac agttgcgcag cctgaatggc gaatgggacg cgccctgtag 4320
cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag 4380
cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt 4440
tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca 4500
cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata 4560
gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca 4620
aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc 4680
gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattttaa 4740
caaaatatta acgcttacaa tttag                                       4765

<210> 35
<211> 5882
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 pCAL IT*
      

<400> 35
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt 180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt 240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt 300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg 360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga 420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa 480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga 540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa 600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca 660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta 720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac 780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc 840
gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag 900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga 960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt 1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata 1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag 1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa 1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt 1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc 1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa 1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa 1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc 1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa 1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa 1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg 1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc 1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg 1800
ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg 1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg 1920
aagcgacacc atcgaatggc gcaaaacctt tcgcggtatg gcatgatagc gcccggaaga 1980
gagtcaattc agggtggtga atgtgaaacc agtaacgtta tacgatgtcg cagagtatgc 2040
cggtgtctct tatcagaccg tttcccgcgt ggtgaaccag gccagccacg tttctgcgaa 2100
aacgcgggaa aaagtggaag cggcgatggc ggagctgaat tacattccca accgcgtggc 2160
acaacaactg gcgggcaaac agtcgttgct gattggcgtt gccacctcca gtctggccct 2220
gcacgcgccg tcgcaaattg tcgcggcgat taaatctcgc gccgatcaac tgggtgccag 2280
cgtggtggtg tcgatggtag aacgaagcgg cgtcgaagcc tgtaaagcgg cggtgcacaa 2340
tcttctcgcg caacgcgtca gtgggctgat cattaactat ccgctggatg accaggatgc 2400
cattgctgtg gaagctgcct gcactaatgt tccggcgtta tttcttgatg tctctgacca 2460
gacacccatc aacagtatta ttttctccca tgaagacggt acgcgactgg gcgtggagca 2520
tctggtcgca ttgggtcacc agcaaatcgc gctgttagcg ggcccattaa gttctgtctc 2580
ggcgcgtctg cgtctggctg gctggcataa atatctcact cgcaatcaaa ttcagccgat 2640
agcggaacgg gaaggcgact ggagtgccat gtccggtttt caacaaacca tgcaaatgct 2700
gaatgagggc atcgttccca ctgcgatgct ggttgccaac gatcagatgg cgctgggcgc 2760
aatgcgcgcc attaccgagt ccgggctgcg cgttggtgcg gatatctcgg tagtgggata 2820
cgacgatacc gaagacagct catgttatat cccgccgtta accaccatca aacaggattt 2880
tcgcctgctg gggcaaacca gcgtggaccg cttgctgcaa ctctctcagg gccaggcggt 2940
gaagggcaat cagctgttgc ccgtctcact ggtgaaaaga aaaaccaccc tggcgcccaa 3000
tacgcaaacc gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt 3060
ttcccgactg gaaagcgggc agtgagcggt acccgataaa agcggcttcc tgacaggagg 3120
ccgttttgtt ttgcagccca cctcaacgca attaatgtga gttagctcac tcattaggca 3180
ccccaggctt tacactttat gcttccggct cgtatgttgt gtggaattgt gagcggataa 3240
caattgaatt aaggaggata taattatgaa atacctgctg ccgaccgcag ccgctggtct 3300
gctgctgctc gcggcctagc cggccatggc cgccggtgtt gttatgaccc agtctccgtc 3360
taccctgtct gcttctgttg gtgacaccat caccatcacc tgccgtgctt ctcagtctat 3420
cgaaacctgg ctggcttggt accagcagaa accgggtaaa gctccgaaac tgctgatcta 3480
caaggcttct accctgaaaa ccggtgttcc gtctcgtttc tctggttctg gttctggtac 3540
cgagttcacc ctgaccatct ctggtctgca gttcgacgac ttcgctacct accactgcca 3600
gcactacgct ggttactctg ctaccttcgg tcagggtacc cgtgttgaaa tcaaacgtac 3660
cgttgctgct ccgtctgttt tcatcttccc gccgtctgac gaacagctga aatctggtac 3720
cgcttctgtt gtttgcctgc tgaacaactt ctacccgcgt gaagctaaag ttcagtggaa 3780
agttgacaac gctctgcagt ctggtaactc tcaggaatct gttaccgaac aggactctaa 3840
agactctacc tactctctgt cttctaccct gaccctgtct aaagctgact acgaaaagca 3900
caaagtttac gcttgcgaag ttacccacca gggtctgtct tctccggtta ccaaatcttt 3960
caaccgtggt gaatgctaat taattaataa ggaggatata attatgaaaa agacagctat 4020
cgcgattgca gtggcactgg ctggtttcgc taccgtagcc taggcggccg cagaagttca 4080
gctggttgaa tctggtggtg gtctggttaa agctggtggt tctctgatcc tgtcttgcgg 4140
tgtttctaac ttccgtatct ctgctcacac catgaactgg gttcgtcgtg ttccgggtgg 4200
tggtctggaa tgggttgctt ctatctctac ctcttctacc taccgtgact acgctgacgc 4260
tgttaaaggt cgtttcaccg tttctcgtga cgacctggaa gacttcgttt acctgcagat 4320
gcataaaatg cgtgttgaag acaccgctat ctactactgc gctcgtaaag gttctgaccg 4380
tctgtctgac aacgacccgt tcgacgcttg gggtccgggt accgttgtta ccgtttctcc 4440
ggcgtcgacc aaaggtccgt ctgttttccc gctggctccg tcttctaaat ctacctctgg 4500
tggtaccgct gctctgggtt gcctggttaa agactacttc ccggaaccgg ttaccgtttc 4560
ttggaactct ggtgctctga cctctggtgt tcacaccttc ccggctgttc tgcagtcttc 4620
tggtctgtac tctctgtctt ctgttgttac cgttccgtct tcttctctgg gtacccagac 4680
ctacatctgc aacgttaacc acaaaccgtc taacaccaaa gttgacaaga aagttgaacc 4740
gaaatcttgc ctgcgatcgc ggccaggccg gccgcaccat caccatcacc atggcgcata 4800
cccgtacgac gttccggact acgcttctac tagttaggag ggtggtggct ctgagggtgg 4860
cggttctgag ggtggcggct ctgagggagg cggttccggt ggtggctctg gttccggtga 4920
ttttgattat gaaaagatgg caaacgctaa taagggggct atgaccgaaa atgccgatga 4980
aaacgcgcta cagtctgacg ctaaaggcaa acttgattct gtcgctactg attacggtgc 5040
tgctatcgat ggtttcattg gtgacgtttc cggccttgct aatggtaatg gtgctactgg 5100
tgattttgct ggctctaatt cccaaatggc tcaagtcggt gacggtgata attcaccttt 5160
aatgaataat ttccgtcaat atttaccttc cctccctcaa tcggttgaat gtcgcccttt 5220
tgtctttggc gctggtaaac catatgaatt ttctattgat tgtgacaaaa taaacttatt 5280
ccgtggtgtc tttgcgtttc ttttatatgt tgccaccttt atgtatgtat tttctacgtt 5340
tgctaacata ctgcgtaata aggagtctta agctagctaa cgatcgccct tcccaacagt 5400
tgcgcagcct gaatggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg 5460
tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg 5520
ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg 5580
ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt 5640
agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt 5700
tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta 5760
tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa 5820
atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg cttacaattt 5880
ag                                                                5882


<210> 36
<211> 5882
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 pCAL ITPO vector

<400> 36
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt 180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt 240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt 300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg 360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga 420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa 480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga 540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa 600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca 660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta 720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac 780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc 840
gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag 900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga 960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt 1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata 1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag 1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa 1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt 1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc 1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa 1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa 1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc 1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa 1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa 1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg 1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc 1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg 1800
ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg 1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg 1920
aagcgacacc atcgaatggc gcaaaacctt tcgcggtatg gcatgatagc gcccggaaga 1980
gagtcaattc agggtggtga atgtgaaacc agtaacgtta tacgatgtcg cagagtatgc 2040
cggtgtctct tatcagaccg tttcccgcgt ggtgaaccag gccagccacg tttctgcgaa 2100
aacgcgggaa aaagtggaag cggcgatggc ggagctgaat tacattccca accgcgtggc 2160
acaacaactg gcgggcaaac agtcgttgct gattggcgtt gccacctcca gtctggccct 2220
gcacgcgccg tcgcaaattg tcgcggcgat taaatctcgc gccgatcaac tgggtgccag 2280
cgtggtggtg tcgatggtag aacgaagcgg cgtcgaagcc tgtaaagcgg cggtgcacaa 2340
tcttctcgcg caacgcgtca gtgggctgat cattaactat ccgctggatg accaggatgc 2400
cattgctgtg gaagctgcct gcactaatgt tccggcgtta tttcttgatg tctctgacca 2460
gacacccatc aacagtatta ttttctccca tgaagacggt acgcgactgg gcgtggagca 2520
tctggtcgca ttgggtcacc agcaaatcgc gctgttagcg ggcccattaa gttctgtctc 2580
ggcgcgtctg cgtctggctg gctggcataa atatctcact cgcaatcaaa ttcagccgat 2640
agcggaacgg gaaggcgact ggagtgccat gtccggtttt caacaaacca tgcaaatgct 2700
gaatgagggc atcgttccca ctgcgatgct ggttgccaac gatcagatgg cgctgggcgc 2760
aatgcgcgcc attaccgagt ccgggctgcg cgttggtgcg gatatctcgg tagtgggata 2820
cgacgatacc gaagacagct catgttatat cccgccgtta accaccatca aacaggattt 2880
tcgcctgctg gggcaaacca gcgtggaccg cttgctgcaa ctctctcagg gccaggcggt 2940
gaagggcaat cagctgttgc ccgtctcact ggtgaaaaga aaaaccaccc tggcgcccaa 3000
tacgcaaacc gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt 3060
ttcccgactg gaaagcgggc agtgagcggt acccgataaa agcggcttcc tgacaggagg 3120
ccgttttgtt ttgcagccca cctcaacgca attaatgtga gttagctcac tcattaggca 3180
ccccaggctt tacactttat gcttccggct cgtatgttgt gtggaattgt gagcggataa 3240
caattgaatt aaggaggata taattatgaa atacctgctg ccgaccgcag ccgctggtct 3300
gctgctgctc gcggcccagc cggccatggc cgccggtgtt gttatgaccc agtctccgtc 3360
taccctgtct gcttctgttg gtgacaccat caccatcacc tgccgtgctt ctcagtctat 3420
cgaaacctgg ctggcttggt accagcagaa accgggtaaa gctccgaaac tgctgatcta 3480
caaggcttct accctgaaaa ccggtgttcc gtctcgtttc tctggttctg gttctggtac 3540
cgagttcacc ctgaccatct ctggtctgca gttcgacgac ttcgctacct accactgcca 3600
gcactacgct ggttactctg ctaccttcgg tcagggtacc cgtgttgaaa tcaaacgtac 3660
cgttgctgct ccgtctgttt tcatcttccc gccgtctgac gaacagctga aatctggtac 3720
cgcttctgtt gtttgcctgc tgaacaactt ctacccgcgt gaagctaaag ttcagtggaa 3780
agttgacaac gctctgcagt ctggtaactc tcaggaatct gttaccgaac aggactctaa 3840
agactctacc tactctctgt cttctaccct gaccctgtct aaagctgact acgaaaagca 3900
caaagtttac gcttgcgaag ttacccacca gggtctgtct tctccggtta ccaaatcttt 3960
caaccgtggt gaatgctaat taattaataa ggaggatata attatgaaaa agacagctat 4020
cgcgattgca gtggcactgg ctggtttcgc taccgtagcc caggcggccg cagaagttca 4080
gctggttgaa tctggtggtg gtctggttaa agctggtggt tctctgatcc tgtcttgcgg 4140
tgtttctaac ttccgtatct ctgctcacac catgaactgg gttcgtcgtg ttccgggtgg 4200
tggtctggaa tgggttgctt ctatctctac ctcttctacc taccgtgact acgctgacgc 4260
tgttaaaggt cgtttcaccg tttctcgtga cgacctggaa gacttcgttt acctgcagat 4320
gcataaaatg cgtgttgaag acaccgctat ctactactgc gctcgtaaag gttctgaccg 4380
tctgtctgac aacgacccgt tcgacgcttg gggtccgggt accgttgtta ccgtttctcc 4440
ggcgtcgacc aaaggtccgt ctgttttccc gctggctccg tcttctaaat ctacctctgg 4500
tggtaccgct gctctgggtt gcctggttaa agactacttc ccggaaccgg ttaccgtttc 4560
ttggaactct ggtgctctga cctctggtgt tcacaccttc ccggctgttc tgcagtcttc 4620
tggtctgtac tctctgtctt ctgttgttac cgttccgtct tcttctctgg gtacccagac 4680
ctacatctgc aacgttaacc acaaaccgtc taacaccaaa gttgacaaga aagttgaacc 4740
gaaatcttgc ctgcgatcgc ggccaggccg gccgcaccat caccatcacc atggcgcata 4800
cccgtacgac gttccggact acgcttctac tagttaggag ggtggtggct ctgagggtgg 4860
cggttctgag ggtggcggct ctgagggagg cggttccggt ggtggctctg gttccggtga 4920
ttttgattat gaaaagatgg caaacgctaa taagggggct atgaccgaaa atgccgatga 4980
aaacgcgcta cagtctgacg ctaaaggcaa acttgattct gtcgctactg attacggtgc 5040
tgctatcgat ggtttcattg gtgacgtttc cggccttgct aatggtaatg gtgctactgg 5100
tgattttgct ggctctaatt cccaaatggc tcaagtcggt gacggtgata attcaccttt 5160
aatgaataat ttccgtcaat atttaccttc cctccctcaa tcggttgaat gtcgcccttt 5220
tgtctttggc gctggtaaac catatgaatt ttctattgat tgtgacaaaa taaacttatt 5280
ccgtggtgtc tttgcgtttc ttttatatgt tgccaccttt atgtatgtat tttctacgtt 5340
tgctaacata ctgcgtaata aggagtctta agctagctaa cgatcgccct tcccaacagt 5400
tgcgcagcct gaatggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg 5460
tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg 5520
ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg 5580
ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt 5640
agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt 5700
tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta 5760
tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa 5820
atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg cttacaattt 5880
ag                                                                5882


<210> 37
<211> 3
<212> DNA
<213> Artificial Sequence

<220> 
<223> Amber stop

<400> 37
tag                                                               3

<210> 38
<211> 6840
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 Fab hinge in petDuet

<400> 38
ggggaattgt gagcggataa caattcccct ctagaaataa ttttgtttaa ctttaagaag 60
gagatatacc atgaaaaaga cagctatcgc gattgcagtg gcactggctg gtttcgctac 120
cgtggcccag gcggccgttg ttatgaccca gtctccgtct accctgtctg cttctgttgg 180
tgacaccatc accatcacct gccgtgcttc tcagtctatc gaaacctggc tggcttggta 240
ccagcagaaa ccgggtaaag ctccgaaact gctgatctac aaggcttcta ccctgaaaac 300
cggtgttccg tctcgtttct ctggttctgg ttctggtacc gagttcaccc tgaccatctc 360
tggtctgcag ttcgacgact tcgctaccta ccactgccag cactacgctg gttactctgc 420
taccttcggt cagggtaccc gtgttgaaat caaacgtacc gttgctgctc cgtctgtttt 480
catcttcccg ccgtctgacg aacagctgaa atctggtacc gcttctgttg tttgcctgct 540
gaacaacttc tacccgcgtg aagctaaagt tcagtggaaa gttgacaacg ctctgcagtc 600
tggtaactct caggaatctg ttaccgaaca ggactctaaa gactctacct actctctgtc 660
ttctaccctg accctgtcta aagctgacta cgaaaagcac aaagtttacg cttgcgaagt 720
tacccaccag ggtctgtctt ctccggttac caaatctttc aaccgtggtg aatgctaggg 780
ccaggccggc cgcggccgca taatgcttaa gtcgaacaga aagtaatcgt attgtacacg 840
gccgcataat cgaaattaat acgactcact ataggggaat tgtgagcgga taacaattcc 900
ccatcttagt atattagtta agtataagaa ggagatatac atatgaaata cctattgcct 960
acggcagccg ctggattgtt attactcgct gcccaaccag ccatggccga agttcagctg 1020
gttgaatctg gtggtggtct ggttaaagct ggtggttctc tgatcctgtc ttgcggtgtt 1080
tctaacttcc gtatctctgc tcacaccatg aactgggttc gtcgtgttcc gggtggtggt 1140
ctggaatggg ttgcttctat ctctacctct tctacctacc gtgactacgc tgacgctgtt 1200
aaaggtcgtt tcaccgtttc tcgtgacgac ctggaagact tcgtttacct gcagatgcat 1260
aaaatgcgtg ttgaagacac cgctatctac tactgcgctc gtaaaggttc tgaccgtctg 1320
tctgacaacg acccgttcga cgcttggggt ccgggtaccg ttgttaccgt ttctccggcg 1380
tcgaccaaag gtccgtctgt tttcccgctg gctccgtctt ctaaatctac ctctggtggt 1440
accgctgctc tgggttgcct ggttaaagac tacttcccgg aaccggttac cgtttcttgg 1500
aactctggtg ctctgacctc tggtgttcac accttcccgg ctgttctgca gtcttctggt 1560
ctgtactctc tgtcttctgt tgttaccgtt ccgtcttctt ctctgggtac ccagacctac 1620
atctgcaacg ttaaccacaa accgtctaac accaaagttg acaagaaagt tgaaccgaaa 1680
agctgcgata aaacccatac ctgcccgccg tgcccgcacc atcaccatca ccatggcgca 1740
tacccgtacg acgttccgga ctacgcttct tagctcgagt ctggtaaaga aaccgctgct 1800
gcgaaatttg aacgccagca catggactcg tctactagcg cagcttaatt aacctaggct 1860
gctgccaccg ctgagcaata actagcataa ccccttgggg cctctaaacg ggtcttgagg 1920
ggttttttgc tgaaaggagg aactatatcc ggattggcga atgggacgcg ccctgtagcg 1980
gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg 2040
ccctagcgcc cgctcctttc gctttcttcc cttcctttct cgccacgttc gccggctttc 2100
cccgtcaagc tctaaatcgg gggctccctt tagggttccg atttagtgct ttacggcacc 2160
tcgaccccaa aaaacttgat tagggtgatg gttcacgtag tgggccatcg ccctgataga 2220
cggtttttcg ccctttgacg ttggagtcca cgttctttaa tagtggactc ttgttccaaa 2280
ctggaacaac actcaaccct atctcggtct attcttttga tttataaggg attttgccga 2340
tttcggccta ttggttaaaa aatgagctga tttaacaaaa atttaacgcg aattttaaca 2400
aaatattaac gtttacaatt tctggcggca cgatggcatg agattatcaa aaaggatctt 2460
cacctagatc cttttaaatt aaaaatgaag ttttaaatca atctaaagta tatatgagta 2520
aacttggtct gacagttacc aatgcttaat cagtgaggca cctatctcag cgatctgtct 2580
atttcgttca tccatagttg cctgactccc cgtcgtgtag ataactacga tacgggaggg 2640
cttaccatct ggccccagtg ctgcaatgat accgcgagac ccacgctcac cggctccaga 2700
tttatcagca ataaaccagc cagccggaag ggccgagcgc agaagtggtc ctgcaacttt 2760
atccgcctcc atccagtcta ttaattgttg ccgggaagct agagtaagta gttcgccagt 2820
taatagtttg cgcaacgttg ttgccattgc tacaggcatc gtggtgtcac gctcgtcgtt 2880
tggtatggct tcattcagct ccggttccca acgatcaagg cgagttacat gatcccccat 2940
gttgtgcaaa aaagcggtta gctccttcgg tcctccgatc gttgtcagaa gtaagttggc 3000
cgcagtgtta tcactcatgg ttatggcagc actgcataat tctcttactg tcatgccatc 3060
cgtaagatgc ttttctgtga ctggtgagta ctcaaccaag tcattctgag aatagtgtat 3120
gcggcgaccg agttgctctt gcccggcgtc aatacgggat aataccgcgc cacatagcag 3180
aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct caaggatctt 3240
accgctgttg agatccagtt cgatgtaacc cactcgtgca cccaactgat cttcagcatc 3300
ttttactttc accagcgttt ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa 3360
gggaataagg gcgacacgga aatgttgaat actcatactc ttcctttttc aatcatgatt 3420
gaagcattta tcagggttat tgtctcatga gcggatacat atttgaatgt atttagaaaa 3480
ataaacaaat aggtcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca 3540
gaccccgtag aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc 3600
tgcttgcaaa caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta 3660
ccaactcttt ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt 3720
ctagtgtagc cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc 3780
gctctgctaa tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg 3840
ttggactcaa gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg 3900
tgcacacagc ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag 3960
ctatgagaaa gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc 4020
agggtcggaa caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat 4080
agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg 4140
gggcggagcc tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc 4200
tggccttttg ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt 4260
accgcctttg agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca 4320
gtgagcgagg aagcggaaga gcgcctgatg cggtattttc tccttacgca tctgtgcggt 4380
atttcacacc gcatatatgg tgcactctca gtacaatctg ctctgatgcc gcatagttaa 4440
gccagtatac actccgctat cgctacgtga ctgggtcatg gctgcgcccc gacacccgcc 4500
aacacccgct gacgcgccct gacgggcttg tctgctcccg gcatccgctt acagacaagc 4560
tgtgaccgtc tccgggagct gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc 4620
gaggcagctg cggtaaagct catcagcgtg gtcgtgaagc gattcacaga tgtctgcctg 4680
ttcatccgcg tccagctcgt tgagtttctc cagaagcgtt aatgtctggc ttctgataaa 4740
gcgggccatg ttaagggcgg ttttttcctg tttggtcact gatgcctccg tgtaaggggg 4800
atttctgttc atgggggtaa tgataccgat gaaacgagag aggatgctca cgatacgggt 4860
tactgatgat gaacatgccc ggttactgga acgttgtgag ggtaaacaac tggcggtatg 4920
gatgcggcgg gaccagagaa aaatcactca gggtcaatgc cagcgcttcg ttaatacaga 4980
tgtaggtgtt ccacagggta gccagcagca tcctgcgatg cagatccgga acataatggt 5040
gcagggcgct gacttccgcg tttccagact ttacgaaaca cggaaaccga agaccattca 5100
tgttgttgct caggtcgcag acgttttgca gcagcagtcg cttcacgttc gctcgcgtat 5160
cggtgattca ttctgctaac cagtaaggca accccgccag cctagccggg tcctcaacga 5220
caggagcacg atcatgctag tcatgccccg cgcccaccgg aaggagctga ctgggttgaa 5280
ggctctcaag ggcatcggtc gagatcccgg tgcctaatga gtgagctaac ttacattaat 5340
tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg 5400
aatcggccaa cgcgcgggga gaggcggttt gcgtattggg cgccagggtg gtttttcttt 5460
tcaccagtga gacgggcaac agctgattgc ccttcaccgc ctggccctga gagagttgca 5520
gcaagcggtc cacgctggtt tgccccagca ggcgaaaatc ctgtttgatg gtggttaacg 5580
gcgggatata acatgagctg tcttcggtat cgtcgtatcc cactaccgag atgtccgcac 5640
caacgcgcag cccggactcg gtaatggcgc gcattgcgcc cagcgccatc tgatcgttgg 5700
caaccagcat cgcagtggga acgatgccct cattcagcat ttgcatggtt tgttgaaaac 5760
cggacatggc actccagtcg ccttcccgtt ccgctatcgg ctgaatttga ttgcgagtga 5820
gatatttatg ccagccagcc agacgcagac gcgccgagac agaacttaat gggcccgcta 5880
acagcgcgat ttgctggtga cccaatgcga ccagatgctc cacgcccagt cgcgtaccgt 5940
cttcatggga gaaaataata ctgttgatgg gtgtctggtc agagacatca agaaataacg 6000
ccggaacatt agtgcaggca gcttccacag caatggcatc ctggtcatcc agcggatagt 6060
taatgatcag cccactgacg cgttgcgcga gaagattgtg caccgccgct ttacaggctt 6120
cgacgccgct tcgttctacc atcgacacca ccacgctggc acccagttga tcggcgcgag 6180
atttaatcgc cgcgacaatt tgcgacggcg cgtgcagggc cagactggag gtggcaacgc 6240
caatcagcaa cgactgtttg cccgccagtt gttgtgccac gcggttggga atgtaattca 6300
gctccgccat cgccgcttcc actttttccc gcgttttcgc agaaacgtgg ctggcctggt 6360
tcaccacgcg ggaaacggtc tgataagaga caccggcata ctctgcgaca tcgtataacg 6420
ttactggttt cacattcacc accctgaatt gactctcttc cgggcgctat catgccatac 6480
cgcgaaaggt tttgcgccat tcgatggtgt ccgggatctc gacgctctcc cttatgcgac 6540
tcctgcatta ggaagcagcc cagtagtagg ttgaggccgt tgagcaccgc cgccgcaagg 6600
aatggtgcat gcaaggagat ggcgcccaac agtcccccgg ccacggggcc tgccaccata 6660
cccacgccga aacaagcgct catgagcccg aagtggcgag cccgatcttc cccatcggtg 6720
atgtcggcga tataggcgcc agcaaccgca cctgtggcgc cggtgatgcc ggccacgatg 6780
cgtccggcgt agaggatcga gatcgatctc gatcccgcga aattaatacg actcactata 6840


<210> 39
<211> 6121
<212> DNA
<213> Artificial Sequence

<220> 
<223> vector with 2G12 domain exchanged scFv

<400> 39
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg 60
cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc 120
ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg 180
gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc 240
acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt 300
ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc 360
ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta 420
acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt 480
tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta 540
tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat 600
tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa 660
actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc 720
gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga 780
aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc 840
agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac 900
cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac 960
aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatat 1020
tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag 1080
tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca 1140
taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac 1200
ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg 1260
tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca 1320
tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac 1380
cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa 1440
cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga 1500
gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg 1560
gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc 1620
agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag 1680
aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc 1740
agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg 1800
cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac 1860
accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga 1920
aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt 1980
ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag 2040
cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg 2100
gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta 2160
tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc 2220
agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg 2280
tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta 2340
caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg 2400
ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct 2460
gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag 2520
gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc 2580
gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag 2640
aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt 2700
ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa 2760
acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg 2820
ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg 2880
tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc 2940
tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta 3000
cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca 3060
gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc 3120
ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc 3180
catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa 3240
ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc 3300
gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac 3360
gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca 3420
ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta 3480
atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa 3540
cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat 3600
tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca 3660
ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa 3720
aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt 3780
atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg 3840
cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca 3900
gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta 3960
tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg 4020
agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat 4080
gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct 4140
ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg 4200
catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat 4260
tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc 4320
tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca 4380
gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg 4440
ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt 4500
tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg 4560
catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct 4620
cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga 4680
tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg 4740
ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc 4800
ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg 4860
cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg 4920
gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc gatcccgcga 4980
aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagaaataa 5040
ttttgtttaa ctttaagaag gagatatacc atgaaaaaga cagctatcgc gattgcagtg 5100
gcactggctg gtttcgctac cgtggcccag gcggccgttg ttatgaccca gtctccgtct 5160
accctgtctg cttctgttgg tgacaccatc accatcacct gccgtgcttc tcagtctatc 5220
gaaacctggc tggcttggta ccagcagaaa ccgggtaaag ctccgaaact gctgatctac 5280
aaggcttcta ccctgaaaac cggtgttccg tctcgtttct ctggttctgg ttctggtacc 5340
gagttcaccc tgaccatctc tggtctgcag ttcgacgact tcgctaccta ccactgccag 5400
cactacgctg gttactctgc taccttcggt cagggtaccc gtgttgaaat caaaggtggt 5460
tcgtctggat cttcctcctc tggtggcggt ggctcgggcg gtggtggcga agttcagctg 5520
gttgaatctg gtggtggtct ggttaaagct ggtggttctc tgatcctgtc ttgcggtgtt 5580
tctaacttcc gtatctctgc tcacaccatg aactgggttc gtcgtgttcc gggtggtggt 5640
ctggaatggg ttgcttctat ctctacctct tctacctacc gtgactacgc tgacgctgtt 5700
aaaggtcgtt tcaccgtttc tcgtgacgac ctggaagact tcgtttacct gcagatgcac 5760
aaaatgcgtg ttgaagacac cgctatctac tactgcgctc gtaaaggttc tgaccgtctg 5820
tctgacaacg acccgttcga cgcttggggt ccgggtaccg ttgttaccgt ttctccgggc 5880
caggccggcc agcaccatca ccatcaccat ggcgcatacc cgtacgacgt tccggactac 5940
gcttcttagg cggccgcact cgagcaccac caccaccacc actgagatcc ggctgctaac 6000
aaagcccgaa aggaagctga gttggctgct gccaccgctg agcaataact agcataaccc 6060
cttggggcct ctaaacgggt cttgaggggt tttttgctga aaggaggaac tatatccgga 6120
t                                                                 6121


<210> 40
<211> 6916
<212> DNA
<213> Artificial Sequence

<220> 
<223> vector w/ 2G12 domain exchanged scFv tandem

<400> 40
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg 60
cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc 120
ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg 180
gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc 240
acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt 300
ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc 360
ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta 420
acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt 480
tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta 540
tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat 600
tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa 660
actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc 720
gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga 780
aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc 840
agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac 900
cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac 960
aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatat 1020
tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag 1080
tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca 1140
taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac 1200
ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg 1260
tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca 1320
tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac 1380
cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa 1440
cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga 1500
gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg 1560
gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc 1620
agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag 1680
aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc 1740
agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg 1800
cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac 1860
accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga 1920
aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt 1980
ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag 2040
cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg 2100
gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta 2160
tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc 2220
agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg 2280
tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta 2340
caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg 2400
ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct 2460
gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag 2520
gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc 2580
gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag 2640
aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt 2700
ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa 2760
acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg 2820
ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg 2880
tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc 2940
tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta 3000
cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca 3060
gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc 3120
ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc 3180
catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa 3240
ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc 3300
gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac 3360
gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca 3420
ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta 3480
atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa 3540
cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat 3600
tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca 3660
ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa 3720
aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt 3780
atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg 3840
cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca 3900
gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta 3960
tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg 4020
agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat 4080
gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct 4140
ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg 4200
catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat 4260
tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc 4320
tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca 4380
gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg 4440
ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt 4500
tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg 4560
catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct 4620
cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga 4680
tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg 4740
ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc 4800
ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg 4860
cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg 4920
gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc gatcccgcga 4980
aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagaaataa 5040
ttttgtttaa ctttaagaag gagatatacc atgaaaaaga cagctatcgc gattgcagtg 5100
gcactggctg gtttcgctac cgtggcccag gcggccgttg ttatgaccca gtctccgtct 5160
accctgtctg cttctgttgg tgacaccatc accatcacct gccgtgcttc tcagtctatc 5220
gaaacctggc tggcttggta ccagcagaaa ccgggtaaag ctccgaaact gctgatctac 5280
aaggcttcta ccctgaaaac cggtgttccg tctcgtttct ctggttctgg ttctggtacc 5340
gagttcaccc tgaccatctc tggtctgcag ttcgacgact tcgctaccta ccactgccag 5400
cactacgctg gttactctgc taccttcggt cagggtaccc gtgttgaaat caaaggtggt 5460
tcgtctggat cttcctcctc tggtggcggt ggctcgggcg gtggtggcga agttcagctg 5520
gttgaatctg gtggtggtct ggttaaagct ggtggttctc tgatcctgtc ttgcggtgtt 5580
tctaacttcc gtatctctgc tcacaccatg aactgggttc gtcgtgttcc gggtggtggt 5640
ctggaatggg ttgcttctat ctctacctct tctacctacc gtgactacgc tgacgctgtt 5700
aaaggtcgtt tcaccgtttc tcgtgacgac ctggaagact tcgtttacct gcagatgcac 5760
aaaatgcgtg ttgaagacac cgctatctac tactgcgctc gtaaaggttc tgaccgtctg 5820
tctgacaacg acccgttcga cgcttggggt ccgggtaccg ttgttaccgt ttctccggga 5880
ggatccggca gcagcagcag cggcggcggc ggcgggagct ccggcggcgg agaagttcag 5940
ctggttgaat ctggtggtgg tctggttaaa gctggtggtt ctctgatcct gtcttgcggt 6000
gtttctaact tccgtatctc tgctcacacc atgaactggg ttcgtcgtgt tccgggtggt 6060
ggtctggaat gggttgcttc tatctctacc tcttctacct accgtgacta cgctgacgct 6120
gttaaaggtc gtttcaccgt ttctcgtgac gacctggaag acttcgttta cctgcagatg 6180
cacaaaatgc gtgttgaaga caccgctatc tactactgcg ctcgtaaagg ttctgaccgt 6240
ctgtctgaca acgacccgtt cgacgcttgg ggtccgggta ccgttgttac cgtttctccg 6300
ggtggttcgt ctggatcttc ctcctctggt ggcggtggct cgggcggtgg tggcgttgtt 6360
atgacccagt ctccgtctac cctgtctgct tctgttggtg acaccatcac catcacctgc 6420
cgtgcttctc agtctatcga aacctggctg gcttggtacc agcagaaacc gggtaaagct 6480
ccgaaactgc tgatctacaa ggcttctacc ctgaaaaccg gtgttccgtc tcgtttctct 6540
ggttctggtt ctggtaccga gttcaccctg accatctctg gtctgcagtt cgacgacttc 6600
gctacctacc actgccagca ctacgctggt tactctgcta ccttcggtca gggtacccgt 6660
gttgaaatca aaggccaggc cggccagcac catcaccatc accatggcgc atacccgtac 6720
gacgttccgg actacgcttc ttaggcggcc gcactcgagc accaccacca ccaccactga 6780
gatccggctg ctaacaaagc ccgaaaggaa gctgagttgg ctgctgccac cgctgagcaa 6840
taactagcat aaccccttgg ggcctctaaa cgggtcttga ggggtttttt gctgaaagga 6900
ggaactatat ccggat                                                 6916


<210> 41
<211> 6166
<212> DNA
<213> Artificial Sequence

<220> 
<223> vector w/ 2G12 domain exchanged scFv hinge(E)

<400> 41
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg 60
cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc 120
ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg 180
gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc 240
acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt 300
ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc 360
ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta 420
acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt 480
tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta 540
tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat 600
tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa 660
actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc 720
gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga 780
aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc 840
agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac 900
cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac 960
aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatat 1020
tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag 1080
tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca 1140
taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac 1200
ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg 1260
tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca 1320
tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac 1380
cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa 1440
cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga 1500
gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg 1560
gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc 1620
agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag 1680
aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc 1740
agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg 1800
cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac 1860
accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga 1920
aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt 1980
ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag 2040
cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg 2100
gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta 2160
tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc 2220
agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg 2280
tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta 2340
caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg 2400
ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct 2460
gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag 2520
gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc 2580
gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag 2640
aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt 2700
ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa 2760
acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg 2820
ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg 2880
tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc 2940
tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta 3000
cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca 3060
gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc 3120
ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc 3180
catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa 3240
ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc 3300
gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac 3360
gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca 3420
ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta 3480
atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa 3540
cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat 3600
tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca 3660
ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa 3720
aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt 3780
atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg 3840
cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca 3900
gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta 3960
tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg 4020
agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat 4080
gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct 4140
ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg 4200
catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat 4260
tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc 4320
tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca 4380
gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg 4440
ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt 4500
tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg 4560
catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct 4620
cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga 4680
tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg 4740
ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc 4800
ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg 4860
cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg 4920
gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc gatcccgcga 4980
aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagaaataa 5040
ttttgtttaa ctttaagaag gagatatacc atgaaaaaga cagctatcgc gattgcagtg 5100
gcactggctg gtttcgctac cgtggcccag gcggccgttg ttatgaccca gtctccgtct 5160
accctgtctg cttctgttgg tgacaccatc accatcacct gccgtgcttc tcagtctatc 5220
gaaacctggc tggcttggta ccagcagaaa ccgggtaaag ctccgaaact gctgatctac 5280
aaggcttcta ccctgaaaac cggtgttccg tctcgtttct ctggttctgg ttctggtacc 5340
gagttcaccc tgaccatctc tggtctgcag ttcgacgact tcgctaccta ccactgccag 5400
cactacgctg gttactctgc taccttcggt cagggtaccc gtgttgaaat caaaggtggt 5460
tcgtctggat cttcctcctc tggtggcggt ggctcgggcg gtggtggcga agttcagctg 5520
gttgaatctg gtggtggtct ggttaaagct ggtggttctc tgatcctgtc ttgcggtgtt 5580
tctaacttcc gtatctctgc tcacaccatg aactgggttc gtcgtgttcc gggtggtggt 5640
ctggaatggg ttgcttctat ctctacctct tctacctacc gtgactacgc tgacgctgtt 5700
aaaggtcgtt tcaccgtttc tcgtgacgac ctggaagact tcgtttacct gcagatgcac 5760
aaaatgcgtg ttgaagacac cgctatctac tactgcgctc gtaaaggttc tgaccgtctg 5820
tctgacaacg acccgttcga cgcttggggt ccgggtaccg ttgttaccgt ttctccggaa 5880
ccgaaaagct gcgataaaac ccatacctgc ccgccgtgcc cgggccaggc cggccagcac 5940
catcaccatc accatggcgc atacccgtac gacgttccgg actacgcttc ttaggcggcc 6000
gcactcgagc accaccacca ccaccactga gatccggctg ctaacaaagc ccgaaaggaa 6060
gctgagttgg ctgctgccac cgctgagcaa taactagcat aaccccttgg ggcctctaaa 6120
cgggtcttga ggggtttttt gctgaaagga ggaactatat ccggat                6166


<210> 42
<211> 6163
<212> DNA
<213> Artificial Sequence

<220> 
<223> vector w/ 2G12 domain exchanged scFv hinge deltaE

<400> 42
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg 60
cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc 120
ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg 180
gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc 240
acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt 300
ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc 360
ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta 420
acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt 480
tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta 540
tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat 600
tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa 660
actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc 720
gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga 780
aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc 840
agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac 900
cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac 960
aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatat 1020
tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag 1080
tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca 1140
taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac 1200
ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg 1260
tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca 1320
tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac 1380
cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa 1440
cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga 1500
gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg 1560
gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc 1620
agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag 1680
aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc 1740
agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg 1800
cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac 1860
accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga 1920
aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt 1980
ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag 2040
cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg 2100
gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta 2160
tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc 2220
agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg 2280
tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta 2340
caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg 2400
ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct 2460
gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag 2520
gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc 2580
gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag 2640
aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt 2700
ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa 2760
acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg 2820
ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg 2880
tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc 2940
tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta 3000
cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca 3060
gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc 3120
ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc 3180
catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa 3240
ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc 3300
gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac 3360
gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca 3420
ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta 3480
atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa 3540
cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat 3600
tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca 3660
ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa 3720
aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt 3780
atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg 3840
cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca 3900
gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta 3960
tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg 4020
agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat 4080
gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct 4140
ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg 4200
catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat 4260
tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc 4320
tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca 4380
gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg 4440
ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt 4500
tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg 4560
catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct 4620
cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga 4680
tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg 4740
ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc 4800
ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg 4860
cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg 4920
gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc gatcccgcga 4980
aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagaaataa 5040
ttttgtttaa ctttaagaag gagatatacc atgaaaaaga cagctatcgc gattgcagtg 5100
gcactggctg gtttcgctac cgtggcccag gcggccgttg ttatgaccca gtctccgtct 5160
accctgtctg cttctgttgg tgacaccatc accatcacct gccgtgcttc tcagtctatc 5220
gaaacctggc tggcttggta ccagcagaaa ccgggtaaag ctccgaaact gctgatctac 5280
aaggcttcta ccctgaaaac cggtgttccg tctcgtttct ctggttctgg ttctggtacc 5340
gagttcaccc tgaccatctc tggtctgcag ttcgacgact tcgctaccta ccactgccag 5400
cactacgctg gttactctgc taccttcggt cagggtaccc gtgttgaaat caaaggtggt 5460
tcgtctggat cttcctcctc tggtggcggt ggctcgggcg gtggtggcga agttcagctg 5520
gttgaatctg gtggtggtct ggttaaagct ggtggttctc tgatcctgtc ttgcggtgtt 5580
tctaacttcc gtatctctgc tcacaccatg aactgggttc gtcgtgttcc gggtggtggt 5640
ctggaatggg ttgcttctat ctctacctct tctacctacc gtgactacgc tgacgctgtt 5700
aaaggtcgtt tcaccgtttc tcgtgacgac ctggaagact tcgtttacct gcagatgcac 5760
aaaatgcgtg ttgaagacac cgctatctac tactgcgctc gtaaaggttc tgaccgtctg 5820
tctgacaacg acccgttcga cgcttggggt ccgggtaccg ttgttaccgt ttctccgccg 5880
aaaagctgcg ataaaaccca tacctgcccg ccgtgcccgg gccaggccgg ccagcaccat 5940
caccatcacc atggcgcata cccgtacgac gttccggact acgcttctta ggcggccgca 6000
ctcgagcacc accaccacca ccactgagat ccggctgcta acaaagcccg aaaggaagct 6060
gagttggctg ctgccaccgc tgagcaataa ctagcataac cccttggggc ctctaaacgg 6120
gtcttgaggg gttttttgct gaaaggagga actatatccg gat                   6163


<210> 43
<211> 424
<212> PRT
<213> Artificial Sequence

<220> 
<223> M13 gene III protein (cp3; g3p; minor coat
      protein; g.i. 59799327)

<400> 43
Met Lys Lys Leu Leu Phe Ala Ile Pro Leu Val Val Pro Phe Tyr Ser
 1               5                  10                  15      
His Ser Ala Glu Thr Val Glu Ser Cys Leu Ala Lys Pro His Thr Glu
            20                  25                  30          
Asn Ser Phe Thr Asn Val Trp Lys Asp Asp Lys Thr Leu Asp Arg Tyr
        35                  40                  45              
Ala Asn Tyr Glu Gly Cys Leu Trp Asn Ala Thr Gly Val Val Val Cys
    50                  55                  60                  
Thr Gly Asp Glu Thr Gln Cys Tyr Gly Thr Trp Val Pro Ile Gly Leu
65                  70                  75                  80  
Ala Ile Pro Glu Asn Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu
                85                  90                  95      
Gly Gly Gly Ser Glu Gly Gly Gly Thr Lys Pro Pro Glu Tyr Gly Asp
            100                 105                 110         
Thr Pro Ile Pro Gly Tyr Thr Tyr Ile Asn Pro Leu Asp Gly Thr Tyr
        115                 120                 125             
Pro Pro Gly Thr Glu Gln Asn Pro Ala Asn Pro Asn Pro Ser Leu Glu
    130                 135                 140                 
Glu Ser Gln Pro Leu Asn Thr Phe Met Phe Gln Asn Asn Arg Phe Arg
145                 150                 155                 160 
Asn Arg Gln Gly Ala Leu Thr Val Tyr Thr Gly Thr Val Thr Gln Gly
                165                 170                 175     
Thr Asp Pro Val Lys Thr Tyr Tyr Gln Tyr Thr Pro Val Ser Ser Lys
            180                 185                 190         
Ala Met Tyr Asp Ala Tyr Trp Asn Gly Lys Phe Arg Asp Cys Ala Phe
        195                 200                 205             
His Ser Gly Phe Asn Glu Asp Pro Phe Val Cys Glu Tyr Gln Gly Gln
    210                 215                 220                 
Ser Ser Asp Leu Pro Gln Pro Pro Val Asn Ala Gly Gly Gly Ser Gly
225                 230                 235                 240 
Gly Gly Ser Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly
                245                 250                 255     
Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Gly Gly Gly Ser Gly
            260                 265                 270         
Ser Gly Asp Phe Asp Tyr Glu Lys Met Ala Asn Ala Asn Lys Gly Ala
        275                 280                 285             
Met Thr Glu Asn Ala Asp Glu Asn Ala Leu Gln Ser Asp Ala Lys Gly
    290                 295                 300                 
Lys Leu Asp Ser Val Ala Thr Asp Tyr Gly Ala Ala Ile Asp Gly Phe
305                 310                 315                 320 
Ile Gly Asp Val Ser Gly Leu Ala Asn Gly Asn Gly Ala Thr Gly Asp
                325                 330                 335     
Phe Ala Gly Ser Asn Ser Gln Met Ala Gln Val Gly Asp Gly Asp Asn
            340                 345                 350         
Ser Pro Leu Met Asn Asn Phe Arg Gln Tyr Leu Pro Ser Leu Pro Gln
        355                 360                 365             
Ser Val Glu Cys Arg Pro Phe Val Phe Ser Ala Gly Lys Pro Tyr Glu
    370                 375                 380                 
Phe Ser Ile Asp Cys Asp Lys Ile Asn Leu Phe Arg Gly Val Phe Ala
385                 390                 395                 400 
Phe Leu Leu Tyr Val Ala Thr Phe Met Tyr Val Phe Ser Thr Phe Ala
                405                 410                 415     
Asn Ile Leu Arg Asn Lys Glu Ser
            420                 


<210> 44
<211> 7
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sap-I cleavage site

<400> 44
gctcttc                                                           7

<210> 45
<211> 7
<212> DNA
<213> Artificial Sequence

<220> 
<223> reverse complement Sap-I cleavage site

<400> 45
gaagagc                                                           7

<210> 46
<211> 923
<212> DNA
<213> Artificial Sequence

<220> 
<223> pComb3x vector containing the Ac8-encoding
      sequence - sequence through the Ab framework into
      the start of gene III

<400> 46
atgaaaaaga cagctatcgc gattgcagtg gcactggctg gtttcgctac cgtggcccag 60
gcggccgaga tagtcctcac gcagtctcca ggcaccctgt ctttgtctcc aggggaaaga 120
gccaccctct cctgcagggc cagtcagagt gttagtagcg cctacttagc ctggtaccag 180
cagaaacctg gccaggctcc caggctcctc atctatggtg catccagcag ggccactggc 240
atcccagaca ggttcagtgg cagtgggtct gggacagact tcactctcac catcagcaga 300
ctggaacctg aagattttgc agtgtattac tgtcagcagt atggtaggtc acccactttc 360
ggcggaggga ccaaggtgga gatcaaaggt ggttcgtcta gatcttcctc ctctggtggc 420
ggtggctcgg gcggtggtgg ccaggtccag ctcgtccagt caggggctga ggtgaagaag 480
cctgggtcct cggtgaaggt ctcctgcaag gcttctggag gttccttcag cagctatgct 540
atcaactggg tgcgacaggc ccctggacaa gggcttgagt ggatgggagg gctcatgcct 600
atctttggga caacaaacta cgcacagaag ttccaggaca gactcacgat taccgcggac 660
gtatccacga gtacagccta catgcagctg agcggcctga catatgaaga cacggccatg 720
tattactgtg cgagagttgc ctatatgttg gaacctaccg tcactgcagg gggtttggac 780
gtctggggcc aagggaccac ggtcaccgtg agctcagctt ccaccaaggg cggccaggcc 840
ggccagcacc atcaccatca ccatggcgca tacccgtacg acgttccgga ctacgcttct 900
taggagggtg gtggctctga ggg                                         923

<210> 47
<211> 70
<212> DNA
<213> Artificial Sequence

<220> 
<223> pCAL_0

<400> 47
agcggaagag cgcccaatac gcaaaccgcc tctccccgcg cgttggccga ttcattaatg 60
cagctggcac                                                        70

<210> 48
<211> 85
<212> DNA
<213> Artificial Sequence

<220> 
<223> pCAL_1
      

<400> 48
gacaggtttc ccgactggaa agcgggcagt gagcgcaacg caattaatgt gagttagctc 60
actcattagg caccccaggc tttac                                       85

<210> 49
<211> 85
<212> DNA
<213> Artificial Sequence

<220> 
<223> pCAL_2
      

<400> 49
actttatgct tccggctcgt atgttgtgtg gaattgtgag cggataacaa ttgaattaag 60
gaggatataa ttatgaaata cctgc                                       85

<210> 50
<211> 85
<212> DNA
<213> Artificial Sequence

<220> 
<223> pCAL_3
      

<400> 50
tgccgaccgc agccgctggt ctgctgctgc tcgcggccca gccggccatg gccgccggtg 60
cctaactctg gctggtttcg ctacc                                       85

<210> 51
<211> 85
<212> DNA
<213> Artificial Sequence

<220> 
<223> pCAL_4
      

<400> 51
gtaaccggtt taattaataa ggaggatata attatgaaaa agacagctat cgcgattgca 60
gtggcactgg ctggtttcgc taccg                                       85

<210> 52
<211> 85
<212> DNA
<213> Artificial Sequence

<220> 
<223> pCAL_5
      

<400> 52
tagcccaggc ggccgcacgc gtctggttga atctggtggg gtctggaatt ctgcgatcgc 60
ggccaggccg gccgcaccat cacca                                       85

<210> 53
<211> 44
<212> DNA
<213> Artificial Sequence

<220> 
<223> pCAL_6
      

<400> 53
tcaccatggc gcatacccgt acgacgttcc ggactacgct tcta                  44

<210> 54
<211> 70
<212> DNA
<213> Artificial Sequence

<220> 
<223> pCAL_7
      

<400> 54
ctagtagaag cgtagtccgg aacgtcgtac gggtatgcgc catggtgatg gtgatggtgc 60
ggccggcctg                                                        70

<210> 55
<211> 85
<212> DNA
<213> Artificial Sequence

<220> 
<223> pCAL_8
      

<400> 55
gccgcgatcg cagaattcca gaccccacca gattcaacca gacgcgtgcg gccgcctggg 60
ctacggtagc gaaaccagcc agtgc                                       85

<210> 56
<211> 85
<212> DNA
<213> Artificial Sequence

<220> 
<223> pCAL_9
      

<400> 56
cactgcaatc gcgatagctg tctttttcat aattatatcc tccttattaa ttaaaccggt 60
tacggtagcg aaaccagcca gagtt                                       85

<210> 57
<211> 85
<212> DNA
<213> Artificial Sequence

<220> 
<223> pCAL_10
      

<400> 57
aggcaccggc ggccatggcc ggctgggccg cgagcagcag cagaccagcg gctgcggtcg 60
gcagcaggta tttcataatt atatc                                       85

<210> 58
<211> 85
<212> DNA
<213> Artificial Sequence

<220> 
<223> pCAL_11
      

<400> 58
ctccttaatt caattgttat ccgctcacaa ttccacacaa catacgagcc ggaagcataa 60
agtgtaaagc ctggggtgcc taatg                                       85

<210> 59
<211> 85
<212> DNA
<213> Artificial Sequence

<220> 
<223> pCAL_12
      

<400> 59
agtgagctaa ctcacattaa ttgcgttgcg ctcactgccc gctttccagt cgggaaacct 60
gtcgtgccag ctgcattaat gaatc                                       85

<210> 60
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> pCAL_13
      

<400> 60
ggccaacgcg cggggagagg cggtttgcgt attgggcgct cttcc                 45

<210> 61
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> SpeIG3-F

<400> 61
ggtggtggtt ctggtactag ttaggagggt ggtg                             34

<210> 62
<211> 52
<212> DNA
<213> Artificial Sequence

<220> 
<223> PvuINheIG3-R

<400> 62
gggaagggcg atcgttagct agcttaagac tccttattac gcagtatgtt ag         52

<210> 63
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> SpeG3A-F

<400> 63
ggtggtggtt ctggtactag ttagaagggt ggtg                             34

<210> 64
<211> 645
<212> DNA
<213> Artificial Sequence

<220> 
<223> NT encoding 3-ALA 2G12 and 2G12 Fab light chain

<400> 64
gccggtgttg ttatgaccca gtctccgtct accctgtctg cttctgttgg tgacaccatc 60
accatcacct gccgtgcttc tcagtctatc gaaacctggc tggcttggta ccagcagaaa 120
ccgggtaaag ctccgaaact gctgatctac aaggcttcta ccctgaaaac cggtgttccg 180
tctcgtttct ctggttctgg ttctggtacc gagttcaccc tgaccatctc tggtctgcag 240
ttcgacgact tcgctaccta ccactgccag cactacgctg gttactctgc taccttcggt 300
cagggtaccc gtgttgaaat caaacgtacc gttgctgctc cgtctgtttt catcttcccg 360
ccgtctgacg aacagctgaa atctggtacc gcttctgttg tttgcctgct gaacaacttc 420
tacccgcgtg aagctaaagt tcagtggaaa gttgacaacg ctctgcagtc tggtaactct 480
caggaatctg ttaccgaaca ggactctaaa gactctacct actctctgtc ttctaccctg 540
accctgtcta aagctgacta cgaaaagcac aaagtttacg cttgcgaagt tacccaccag 600
ggtctgtctt ctccggttac caaatctttc aaccgtggtg aatgc                 645

<210> 65
<211> 684
<212> DNA
<213> Artificial Sequence

<220> 
<223> NT encoding 2G12 Fab  heavy chain

<400> 65
gaagttcagc tggttgaatc tggtggtggt ctggttaaag ctggtggttc tctgatcctg 60
tcttgcggtg tttctaactt ccgtatctct gctcacacca tgaactgggt tcgtcgtgtt 120
ccgggtggtg gtctggaatg ggttgcttct atctctacct cttctaccta ccgtgactac 180
gctgacgctg ttaaaggtcg tttcaccgtt tctcgtgacg acctggaaga cttcgtttac 240
ctgcagatgc ataaaatgcg tgttgaagac accgctatct actactgcgc tcgtaaaggt 300
tctgaccgtc tgtctgacaa cgacccgttc gacgcttggg gtccgggtac cgttgttacc 360
gtttctccgg cgtcgaccaa aggtccgtct gttttcccgc tggctccgtc ttctaaatct 420
acctctggtg gtaccgctgc tctgggttgc ctggttaaag actacttccc ggaaccggtt 480
accgtttctt ggaactctgg tgctctgacc tctggtgttc acaccttccc ggctgttctg 540
cagtcttctg gtctgtactc tctgtcttct gttgttaccg ttccgtcttc ttctctgggt 600
acccagacct acatctgcaa cgttaaccac aaaccgtcta acaccaaagt tgacaagaaa 660
gttgaaccga aatcttgcct gcga                                        684

<210> 66
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> nt sequence encoding HA tag

<400> 66
tacccgtacg acgttccgga ctacgct                                     27

<210> 67
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> AA sequence - HA tag

<400> 67
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala
 1               5                  


<210> 68
<211> 6840
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 heavy and light chain in pET Duet vector
      (Fab)

<400> 68
ggggaattgt gagcggataa caattcccct ctagaaataa ttttgtttaa ctttaagaag 60
gagatatacc atgaaaaaga cagctatcgc gattgcagtg gcactggctg gtttcgctac 120
cgtggcccag gcggccgttg ttatgaccca gtctccgtct accctgtctg cttctgttgg 180
tgacaccatc accatcacct gccgtgcttc tcagtctatc gaaacctggc tggcttggta 240
ccagcagaaa ccgggtaaag ctccgaaact gctgatctac aaggcttcta ccctgaaaac 300
cggtgttccg tctcgtttct ctggttctgg ttctggtacc gagttcaccc tgaccatctc 360
tggtctgcag ttcgacgact tcgctaccta ccactgccag cactacgctg gttactctgc 420
taccttcggt cagggtaccc gtgttgaaat caaacgtacc gttgctgctc cgtctgtttt 480
catcttcccg ccgtctgacg aacagctgaa atctggtacc gcttctgttg tttgcctgct 540
gaacaacttc tacccgcgtg aagctaaagt tcagtggaaa gttgacaacg ctctgcagtc 600
tggtaactct caggaatctg ttaccgaaca ggactctaaa gactctacct actctctgtc 660
ttctaccctg accctgtcta aagctgacta cgaaaagcac aaagtttacg cttgcgaagt 720
tacccaccag ggtctgtctt ctccggttac caaatctttc aaccgtggtg aatgctaggg 780
ccaggccggc cgcggccgca taatgcttaa gtcgaacaga aagtaatcgt attgtacacg 840
gccgcataat cgaaattaat acgactcact ataggggaat tgtgagcgga taacaattcc 900
ccatcttagt atattagtta agtataagaa ggagatatac atatgaaata cctattgcct 960
acggcagccg ctggattgtt attactcgct gcccaaccag ccatggccga agttcagctg 1020
gttgaatctg gtggtggtct ggttaaagct ggtggttctc tgatcctgtc ttgcggtgtt 1080
tctaacttcc gtatctctgc tcacaccatg aactgggttc gtcgtgttcc gggtggtggt 1140
ctggaatggg ttgcttctat ctctacctct tctacctacc gtgactacgc tgacgctgtt 1200
aaaggtcgtt tcaccgtttc tcgtgacgac ctggaagact tcgtttacct gcagatgcat 1260
aaaatgcgtg ttgaagacac cgctatctac tactgcgctc gtaaaggttc tgaccgtctg 1320
tctgacaacg acccgttcga cgcttggggt ccgggtaccg ttgttaccgt ttctccggcg 1380
tcgaccaaag gtccgtctgt tttcccgctg gctccgtctt ctaaatctac ctctggtggt 1440
accgctgctc tgggttgcct ggttaaagac tacttcccgg aaccggttac cgtttcttgg 1500
aactctggtg ctctgacctc tggtgttcac accttcccgg ctgttctgca gtcttctggt 1560
ctgtactctc tgtcttctgt tgttaccgtt ccgtcttctt ctctgggtac ccagacctac 1620
atctgcaacg ttaaccacaa accgtctaac accaaagttg acaagaaagt tgaaccgaaa 1680
agctgcgata aaacccatac ctgcccgccg tgcccgcacc atcaccatca ccatggcgca 1740
tacccgtacg acgttccgga ctacgcttct tagctcgagt ctggtaaaga aaccgctgct 1800
gcgaaatttg aacgccagca catggactcg tctactagcg cagcttaatt aacctaggct 1860
gctgccaccg ctgagcaata actagcataa ccccttgggg cctctaaacg ggtcttgagg 1920
ggttttttgc tgaaaggagg aactatatcc ggattggcga atgggacgcg ccctgtagcg 1980
gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg 2040
ccctagcgcc cgctcctttc gctttcttcc cttcctttct cgccacgttc gccggctttc 2100
cccgtcaagc tctaaatcgg gggctccctt tagggttccg atttagtgct ttacggcacc 2160
tcgaccccaa aaaacttgat tagggtgatg gttcacgtag tgggccatcg ccctgataga 2220
cggtttttcg ccctttgacg ttggagtcca cgttctttaa tagtggactc ttgttccaaa 2280
ctggaacaac actcaaccct atctcggtct attcttttga tttataaggg attttgccga 2340
tttcggccta ttggttaaaa aatgagctga tttaacaaaa atttaacgcg aattttaaca 2400
aaatattaac gtttacaatt tctggcggca cgatggcatg agattatcaa aaaggatctt 2460
cacctagatc cttttaaatt aaaaatgaag ttttaaatca atctaaagta tatatgagta 2520
aacttggtct gacagttacc aatgcttaat cagtgaggca cctatctcag cgatctgtct 2580
atttcgttca tccatagttg cctgactccc cgtcgtgtag ataactacga tacgggaggg 2640
cttaccatct ggccccagtg ctgcaatgat accgcgagac ccacgctcac cggctccaga 2700
tttatcagca ataaaccagc cagccggaag ggccgagcgc agaagtggtc ctgcaacttt 2760
atccgcctcc atccagtcta ttaattgttg ccgggaagct agagtaagta gttcgccagt 2820
taatagtttg cgcaacgttg ttgccattgc tacaggcatc gtggtgtcac gctcgtcgtt 2880
tggtatggct tcattcagct ccggttccca acgatcaagg cgagttacat gatcccccat 2940
gttgtgcaaa aaagcggtta gctccttcgg tcctccgatc gttgtcagaa gtaagttggc 3000
cgcagtgtta tcactcatgg ttatggcagc actgcataat tctcttactg tcatgccatc 3060
cgtaagatgc ttttctgtga ctggtgagta ctcaaccaag tcattctgag aatagtgtat 3120
gcggcgaccg agttgctctt gcccggcgtc aatacgggat aataccgcgc cacatagcag 3180
aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct caaggatctt 3240
accgctgttg agatccagtt cgatgtaacc cactcgtgca cccaactgat cttcagcatc 3300
ttttactttc accagcgttt ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa 3360
gggaataagg gcgacacgga aatgttgaat actcatactc ttcctttttc aatcatgatt 3420
gaagcattta tcagggttat tgtctcatga gcggatacat atttgaatgt atttagaaaa 3480
ataaacaaat aggtcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca 3540
gaccccgtag aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc 3600
tgcttgcaaa caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta 3660
ccaactcttt ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt 3720
ctagtgtagc cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc 3780
gctctgctaa tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg 3840
ttggactcaa gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg 3900
tgcacacagc ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag 3960
ctatgagaaa gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc 4020
agggtcggaa caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat 4080
agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg 4140
gggcggagcc tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc 4200
tggccttttg ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt 4260
accgcctttg agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca 4320
gtgagcgagg aagcggaaga gcgcctgatg cggtattttc tccttacgca tctgtgcggt 4380
atttcacacc gcatatatgg tgcactctca gtacaatctg ctctgatgcc gcatagttaa 4440
gccagtatac actccgctat cgctacgtga ctgggtcatg gctgcgcccc gacacccgcc 4500
aacacccgct gacgcgccct gacgggcttg tctgctcccg gcatccgctt acagacaagc 4560
tgtgaccgtc tccgggagct gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc 4620
gaggcagctg cggtaaagct catcagcgtg gtcgtgaagc gattcacaga tgtctgcctg 4680
ttcatccgcg tccagctcgt tgagtttctc cagaagcgtt aatgtctggc ttctgataaa 4740
gcgggccatg ttaagggcgg ttttttcctg tttggtcact gatgcctccg tgtaaggggg 4800
atttctgttc atgggggtaa tgataccgat gaaacgagag aggatgctca cgatacgggt 4860
tactgatgat gaacatgccc ggttactgga acgttgtgag ggtaaacaac tggcggtatg 4920
gatgcggcgg gaccagagaa aaatcactca gggtcaatgc cagcgcttcg ttaatacaga 4980
tgtaggtgtt ccacagggta gccagcagca tcctgcgatg cagatccgga acataatggt 5040
gcagggcgct gacttccgcg tttccagact ttacgaaaca cggaaaccga agaccattca 5100
tgttgttgct caggtcgcag acgttttgca gcagcagtcg cttcacgttc gctcgcgtat 5160
cggtgattca ttctgctaac cagtaaggca accccgccag cctagccggg tcctcaacga 5220
caggagcacg atcatgctag tcatgccccg cgcccaccgg aaggagctga ctgggttgaa 5280
ggctctcaag ggcatcggtc gagatcccgg tgcctaatga gtgagctaac ttacattaat 5340
tgcgttgcgc tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg 5400
aatcggccaa cgcgcgggga gaggcggttt gcgtattggg cgccagggtg gtttttcttt 5460
tcaccagtga gacgggcaac agctgattgc ccttcaccgc ctggccctga gagagttgca 5520
gcaagcggtc cacgctggtt tgccccagca ggcgaaaatc ctgtttgatg gtggttaacg 5580
gcgggatata acatgagctg tcttcggtat cgtcgtatcc cactaccgag atgtccgcac 5640
caacgcgcag cccggactcg gtaatggcgc gcattgcgcc cagcgccatc tgatcgttgg 5700
caaccagcat cgcagtggga acgatgccct cattcagcat ttgcatggtt tgttgaaaac 5760
cggacatggc actccagtcg ccttcccgtt ccgctatcgg ctgaatttga ttgcgagtga 5820
gatatttatg ccagccagcc agacgcagac gcgccgagac agaacttaat gggcccgcta 5880
acagcgcgat ttgctggtga cccaatgcga ccagatgctc cacgcccagt cgcgtaccgt 5940
cttcatggga gaaaataata ctgttgatgg gtgtctggtc agagacatca agaaataacg 6000
ccggaacatt agtgcaggca gcttccacag caatggcatc ctggtcatcc agcggatagt 6060
taatgatcag cccactgacg cgttgcgcga gaagattgtg caccgccgct ttacaggctt 6120
cgacgccgct tcgttctacc atcgacacca ccacgctggc acccagttga tcggcgcgag 6180
atttaatcgc cgcgacaatt tgcgacggcg cgtgcagggc cagactggag gtggcaacgc 6240
caatcagcaa cgactgtttg cccgccagtt gttgtgccac gcggttggga atgtaattca 6300
gctccgccat cgccgcttcc actttttccc gcgttttcgc agaaacgtgg ctggcctggt 6360
tcaccacgcg ggaaacggtc tgataagaga caccggcata ctctgcgaca tcgtataacg 6420
ttactggttt cacattcacc accctgaatt gactctcttc cgggcgctat catgccatac 6480
cgcgaaaggt tttgcgccat tcgatggtgt ccgggatctc gacgctctcc cttatgcgac 6540
tcctgcatta ggaagcagcc cagtagtagg ttgaggccgt tgagcaccgc cgccgcaagg 6600
aatggtgcat gcaaggagat ggcgcccaac agtcccccgg ccacggggcc tgccaccata 6660
cccacgccga aacaagcgct catgagcccg aagtggcgag cccgatcttc cccatcggtg 6720
atgtcggcga tataggcgcc agcaaccgca cctgtggcgc cggtgatgcc ggccacgatg 6780
cgtccggcgt agaggatcga gatcgatctc gatcccgcga aattaatacg actcactata 6840


<210> 69
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> pCALVL-F

<400> 69
ccatggccgc cggtgttgtt atgacccagt ctccgtc                          37

<210> 70
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> pCALCK-R
      

<400> 70
ctccttatta attaattagc attcaccacg gttgaaag                         38

<210> 71
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> pCALVH-F primer

<400> 71
gcccaggcgg ccgcagaagt tcagctggtt gaatctggtg                       40

<210> 72
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> pCALCH-R

<400> 72
ctggccgcga tcgcaggcaa gatttcggtt caactttctt g                     41

<210> 73
<211> 228
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 domain exchanged Fab heavy chain (VH-CH1)

<400> 73
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
 1               5                  10                  15      
Ser Leu Ile Leu Ser Cys Gly Val Ser Asn Phe Arg Ile Ser Ala His
            20                  25                  30          
Thr Met Asn Trp Val Arg Arg Val Pro Gly Gly Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Leu Glu Asp Phe Val Tyr
65                  70                  75                  80  
Leu Gln Met His Lys Met Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Gly Ser Asp Arg Leu Ser Asp Asn Asp Pro Phe Asp Ala
            100                 105                 110         
Trp Gly Pro Gly Thr Val Val Thr Val Ser Pro Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
    210                 215                 220                 
Ser Cys Leu Arg
225             


<210> 74
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 and 3-ALA light chain (domain exchanged Fab)

<400> 74
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ala Gly Tyr Ser
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 75
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> 3Ala-R

<400> 75
tcgaacgggt ccgcgtccgc cgcacggtca gaacctttac                       40

<210> 76
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> 3Ala-F
      

<400> 76
gttctgaccg tgcggcggac gcggacccgt tcgacgcttg                       40

<210> 77
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide pool A / primer A

<400> 77
gcccaggcgg ccgcagaagt tcag                                        24

<210> 78
<211> 58
<212> DNA
<213> Artificial Sequence

<220> 
<223> primer E /oligonucleotide pool E

<400> 78
cctttggtcg acgccggaga aacggtaaca acggtacccg gaccccaagc gtcgaacg   58

<210> 79
<211> 6145
<212> DNA
<213> Artificial Sequence

<220> 
<223> pAC8 sequence

<400> 79
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg 60
cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc 120
ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg 180
gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc 240
acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt 300
ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc 360
ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta 420
acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt 480
tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta 540
tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat 600
tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa 660
actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc 720
gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga 780
aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc 840
agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac 900
cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac 960
aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatat 1020
tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag 1080
tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca 1140
taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac 1200
ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg 1260
tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca 1320
tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac 1380
cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa 1440
cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga 1500
gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg 1560
gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc 1620
agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag 1680
aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc 1740
agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg 1800
cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac 1860
accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga 1920
aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt 1980
ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag 2040
cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg 2100
gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta 2160
tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc 2220
agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg 2280
tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta 2340
caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg 2400
ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct 2460
gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag 2520
gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc 2580
gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag 2640
aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt 2700
ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa 2760
acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg 2820
ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg 2880
tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc 2940
tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta 3000
cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca 3060
gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc 3120
ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc 3180
catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa 3240
ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc 3300
gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac 3360
gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca 3420
ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta 3480
atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa 3540
cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat 3600
tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca 3660
ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa 3720
aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt 3780
atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg 3840
cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca 3900
gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta 3960
tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg 4020
agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat 4080
gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct 4140
ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg 4200
catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat 4260
tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc 4320
tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca 4380
gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg 4440
ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt 4500
tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg 4560
catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct 4620
cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga 4680
tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg 4740
ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc 4800
ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg 4860
cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg 4920
gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc gatcccgcga 4980
aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagaaataa 5040
ttttgtttaa ctttaagaag gagatatacc atgaaaaaga cagctatcgc gattgcagtg 5100
gcactggctg gtttcgctac cgtggcccag gcggccgaga tagtcctcac gcagtctcca 5160
ggcaccctgt ctttgtctcc aggggaaaga gccaccctct cctgcagggc cagtcagagt 5220
gttagtagcg cctacttagc ctggtaccag cagaaacctg gccaggctcc caggctcctc 5280
atctatggtg catccagcag ggccactggc atcccagaca ggttcagtgg cagtgggtct 5340
gggacagact tcactctcac catcagcaga ctggaacctg aagattttgc agtgtattac 5400
tgtcagcagt atggtaggtc acccactttc ggcggaggga ccaaggtgga gatcaaaggt 5460
ggttcgtcta gatcttcctc ctctggtggc ggtggctcgg gcggtggtgg ccaggtccag 5520
ctcgtccagt caggggctga ggtgaagaag cctgggtcct cggtgaaggt ctcctgcaag 5580
gcttctggag gttccttcag cagctatgct atcaactggg tgcgacaggc ccctggacaa 5640
gggcttgagt ggatgggagg gctcatgcct atctttggga caacaaacta cgcacagaag 5700
ttccaggaca gactcacgat taccgcggac gtatccacga gtacagccta catgcagctg 5760
agcggcctga catatgaaga cacggccatg tattactgtg cgagagttgc ctatatgttg 5820
gaacctaccg tcactgcagg gggtttggac gtctggggcc aagggaccac ggtcaccgtg 5880
agctcagctt ccaccaaggg cggccaggcc ggccagcacc atcaccatca ccatggcgca 5940
tacccgtacg acgttccgga ctacgcttct taggcggccg cactcgagca ccaccaccac 6000
caccactgag atccggctgc taacaaagcc cgaaaggaag ctgagttggc tgctgccacc 6060
gctgagcaat aactagcata accccttggg gcctctaaac gggtcttgag gggttttttg 6120
ctgaaaggag gaactatatc cggat                                       6145


<210> 80
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> LacITerm-F1 Primer
      

<400> 80
ggcgccgctc ttcgagcgac accatcgaat ggcgcaaaac c                     41

<210> 81
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> LacITerm-R1 Primer
      

<400> 81
cttttatcgg gtaccgctca ctgcccgctt tccagtcggg a                     41

<210> 82
<211> 58
<212> DNA
<213> Artificial Sequence

<220> 
<223> Term-R Primer
      

<400> 82
gctaggtggg ctgcaaaaca aaacggcctc ctgtcaggaa gccgctttta tcgggtac   58

<210> 83
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> LacITerm-F2 Primer
      

<400> 83
aaagcgggca gtgagcggta cccgataaaa gcggcttcct g                     41

<210> 84
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> TermPO-R Primer
      

<400> 84
cacattaatt gcgttgaggt gggctgcaaa acaaaacggc c                     41

<210> 85
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> TermPO-F Primer
      

<400> 85
gttttgcagc ccacctcaac gcaattaatg tgagttagct c                     41

<210> 86
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> SgrAIPelB-R Primer
      

<400> 86
cataacaaca ccggcggcca tggccggctg                                  30

<210> 87
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> SeqpCALTerm-F Primer
      

<400> 87
taaccgtatt accgcctttg                                             20

<210> 88
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> SeqpCALTerm-R Primer
      

<400> 88
tgccagctgc attaatgaat                                             20

<210> 89
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> SeqpCALIT-R Primer
      

<400> 89
cataactcac attaattgcg t                                           21

<210> 90
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> SeqITPO-F2 Primer
      

<400> 90
gttgcccgtc tcactggtga                                             20

<210> 91
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> KasI-F Primer
      

<400> 91
ccaccctggc gcccaatacg caaac                                       25

<210> 92
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> AmbPelB-R Primer
      

<400> 92
gcggccatgg ccggctaggc cgcgagcagc agcagac                          37

<210> 93
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223>  AmbPelB-F Primer
      

<400> 93
tgctgctcgc ggcctagccg gccatggccg ccggtgt                          37

<210> 94
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> AmbOmpA-R Primer
      

<400> 94
gaacttctgc ggccgcctag gctacggtag cgaaac                           36

<210> 95
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> SeqHCFR1-R Primer
      
      

<400> 95
ttagaaacac cgcaagacag                                             20

<210> 96
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> SeqpCAL-F Primer

<400> 96
atataattat gaaatacctg                                             20

<210> 97
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> SeqITPO-F4 Primer

<400> 97
gcgtggaccg cttgctgcaa                                             20

<210> 98
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> CALX24H1S-F primer ; F1

<400> 98
gccgctgtgc catcgctcag taacgcggcc gcagaagttc agctg                 45

<210> 99
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> R1

<400> 99
ggcggcgctc ttcagttaga aacaccgcaa gacaggatc                        39

<210> 100
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> F2

<400> 100
ggcggcgctc ttctcgtgtt ccgggtggtg gtctg                            35

<210> 101
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> R2

<400> 101
ggcggcgctc ttcagtagat agcggtgtct tcaacac                          37

<210> 102
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> F3

<400> 102
ggcggcgctc ttcgggtccg ggtaccgttg ttac                             34

<210> 103
<211> 44
<212> DNA
<213> Artificial Sequence

<220> 
<223> R3

<400> 103
gccgctgtgc catcgctcag taacgtcgac gccggagaaa cggt                  44

<210> 104
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> H1F Primer

<220> 
<221> misc_feature   
<222> 19-20, 22-23
<223> n = a or g or c or t

<220> 
<221> misc_feature   
<222> 24
<223> k = g or t

<400> 104
aacttccgta tctctgctnn tnnkatgaac tgggttcgt                        39

<210> 105
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Reference sequence used to design H1F Primer

<400> 105
aacttccgta tctctgctca caccatgaac tgggttcgt                        39

<210> 106
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> H1R Primer

<220> 
<221> misc_feature   
<222> 19
<223> m = a or c

<220> 
<221> misc_feature   
<222> 20-21, 23-24
<223> n = a or g or c or t

<400> 106
acgacgaacc cagttcatmn nannagcaga gatacggaa                        39

<210> 107
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Reference sequence used to design H1R Primer

<400> 107
acgacgaacc cagttcatgg tgtgagcaga gatacggaa                        39

<210> 108
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> H3F Primer

<220> 
<221> misc_feature   
<222> 19-20, 32-32, 34-35, 40-41, 43-44
<223> n = a or g or c or t

<220> 
<221> misc_feature   
<222> 21, 36, 42, 45
<223> k = g or t

<400> 108
tactactgcg ctcgtaaann ktctgaccgt nntnnkgacn nknnkccgtt cgacgcttgg 60


<210> 109
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> Reference sequence used to design H3F Primer

<400> 109
tactactgcg ctcgtaaagg ttctgaccgt ctgtctgaca acgacccgtt cgacgcttgg 60


<210> 110
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> H3R Primer

<220> 
<221> misc_feature   
<222> 19, 22, 28, 43
<223> m = a or c

<220> 
<221> misc_feature   
<222> 20-21, 23-24, 29-30, 32-33, 44-45
<223> n = a or g or c or t

<400> 110
accccaagcg tcgaacggmn nmnngtcmnn annacggtca gamnntttac gagcgcagta 60


<210> 111
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> Reference sequence used to design H3R Primer

<400> 111
accccaagcg tcgaacgggt cgttgtcaga cagacggtca gaacctttac gagcgcagta 60


<210> 112
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> CALX24 primer

<400> 112
gccgctgtgc catcgctcag taac                                        24

<210> 113
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> OmpA-F Primer

<400> 113
gtggcactgg ctggtttcgc tac                                         23

<210> 114
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> VLL1-R Primer

<400> 114
ggaggaagat ccagacgaac cacctttgat ttcaacacgg gtaccctg              48

<210> 115
<211> 46
<212> DNA
<213> Artificial Sequence

<220> 
<223> L1VH-F Primer

<400> 115
ggtggctcgg gcggtggtgg cgaagttcag ctggttgaat ctggtg                46

<210> 116
<211> 46
<212> DNA
<213> Artificial Sequence

<220> 
<223> VHL2-R Primer

<400> 116
ctgctgctgc tgccggatcc tcccggagaa acggtaacaa cggtac                46

<210> 117
<211> 46
<212> DNA
<213> Artificial Sequence

<220> 
<223> L2VH-F Primer

<400> 117
ggcgggagct ccggcggcgg agaagttcag ctggttgaat ctggtg                46

<210> 118
<211> 47
<212> DNA
<213> Artificial Sequence

<220> 
<223> VHL1-R Primer

<400> 118
ggaggaagat ccagacgaac cacccggaga aacggtaaca acggtac               47

<210> 119
<211> 44
<212> DNA
<213> Artificial Sequence

<220> 
<223> L1VL-F Primer

<400> 119
ggtggctcgg gcggtggtgg cgttgttatg acccagtctc cgtc                  44

<210> 120
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> VLSfi-R Primer

<400> 120
gtgctggccg gcctggcctt tgatttcaac acgggtaccc tg                    42

<210> 121
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Sfi6His-R Primer

<400> 121
gtgatggtgc tggccggcct ggcctttg                                    28

<210> 122
<211> 54
<212> DNA
<213> Artificial Sequence

<220> 
<223> Linker 1(-): (L1 prime)

<400> 122
gccaccaccg cccgagccac cgccaccaga ggcggcagat ccagacgaac cacc       54

<210> 123
<211> 54
<212> DNA
<213> Artificial Sequence

<220> 
<223> Linker 2(-): (L2 prime)

<400> 123
tccgccgccg gagctcccgc cgccgccgcc gctgctgctg ctgccggatc ctcc       54

<210> 124
<211> 6819
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 Fab in pET Duet vector

<400> 124
ggggaattgt gagcggataa caattcccct ctagaaataa ttttgtttaa ctttaagaag 60
gagatatacc atgaaaaaga cagctatcgc gattgcagtg gcactggctg gtttcgctac 120
cgtggcccag gcggccgttg ttatgaccca gtctccgtct accctgtctg cttctgttgg 180
tgacaccatc accatcacct gccgtgcttc tcagtctatc gaaacctggc tggcttggta 240
ccagcagaaa ccgggtaaag ctccgaaact gctgatctac aaggcttcta ccctgaaaac 300
cggtgttccg tctcgtttct ctggttctgg ttctggtacc gagttcaccc tgaccatctc 360
tggtctgcag ttcgacgact tcgctaccta ccactgccag cactacgctg gttactctgc 420
taccttcggt cagggtaccc gtgttgaaat caaacgtacc gttgctgctc cgtctgtttt 480
catcttcccg ccgtctgacg aacagctgaa atctggtacc gcttctgttg tttgcctgct 540
gaacaacttc tacccgcgtg aagctaaagt tcagtggaaa gttgacaacg ctctgcagtc 600
tggtaactct caggaatctg ttaccgaaca ggactctaaa gactctacct actctctgtc 660
ttctaccctg accctgtcta aagctgacta cgaaaagcac aaagtttacg cttgcgaagt 720
tacccaccag ggtctgtctt ctccggttac caaatctttc aaccgtggtg aatgctaggg 780
ccaggccggc cgcggccgca taatgcttaa gtcgaacaga aagtaatcgt attgtacacg 840
gccgcataat cgaaattaat acgactcact ataggggaat tgtgagcgga taacaattcc 900
ccatcttagt atattagtta agtataagaa ggagatatac atatgaaata cctattgcct 960
acggcagccg ctggattgtt attactcgct gcccaaccag ccatggccga agttcagctg 1020
gttgaatctg gtggtggtct ggttaaagct ggtggttctc tgatcctgtc ttgcggtgtt 1080
tctaacttcc gtatctctgc tcacaccatg aactgggttc gtcgtgttcc gggtggtggt 1140
ctggaatggg ttgcttctat ctctacctct tctacctacc gtgactacgc tgacgctgtt 1200
aaaggtcgtt tcaccgtttc tcgtgacgac ctggaagact tcgtttacct gcagatgcat 1260
aaaatgcgtg ttgaagacac cgctatctac tactgcgctc gtaaaggttc tgaccgtctg 1320
tctgacaacg acccgttcga cgcttggggt ccgggtaccg ttgttaccgt ttctccggcg 1380
tcgaccaaag gtccgtctgt tttcccgctg gctccgtctt ctaaatctac ctctggtggt 1440
accgctgctc tgggttgcct ggttaaagac tacttcccgg aaccggttac cgtttcttgg 1500
aactctggtg ctctgacctc tggtgttcac accttcccgg ctgttctgca gtcttctggt 1560
ctgtactctc tgtcttctgt tgttaccgtt ccgtcttctt ctctgggtac ccagacctac 1620
atctgcaacg ttaaccacaa accgtctaac accaaagttg acaagaaagt tgaaccgaaa 1680
tcttgcggca gcagccacca tcaccatcac catggcgcat acccgtacga cgttccggac 1740
tacgcttctt agctcgagtc tggtaaagaa accgctgctg cgaaatttga acgccagcac 1800
atggactcgt ctactagcgc agcttaatta acctaggctg ctgccaccgc tgagcaataa 1860
ctagcataac cccttggggc ctctaaacgg gtcttgaggg gttttttgct gaaaggagga 1920
actatatccg gattggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg 1980
tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg 2040
ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg 2100
ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt 2160
agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt 2220
tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta 2280
tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa 2340
atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg tttacaattt 2400
ctggcggcac gatggcatga gattatcaaa aaggatcttc acctagatcc ttttaaatta 2460
aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa acttggtctg acagttacca 2520
atgcttaatc agtgaggcac ctatctcagc gatctgtcta tttcgttcat ccatagttgc 2580
ctgactcccc gtcgtgtaga taactacgat acgggagggc ttaccatctg gccccagtgc 2640
tgcaatgata ccgcgagacc cacgctcacc ggctccagat ttatcagcaa taaaccagcc 2700
agccggaagg gccgagcgca gaagtggtcc tgcaacttta tccgcctcca tccagtctat 2760
taattgttgc cgggaagcta gagtaagtag ttcgccagtt aatagtttgc gcaacgttgt 2820
tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt cattcagctc 2880
cggttcccaa cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa aagcggttag 2940
ctccttcggt cctccgatcg ttgtcagaag taagttggcc gcagtgttat cactcatggt 3000
tatggcagca ctgcataatt ctcttactgt catgccatcc gtaagatgct tttctgtgac 3060
tggtgagtac tcaaccaagt cattctgaga atagtgtatg cggcgaccga gttgctcttg 3120
cccggcgtca atacgggata ataccgcgcc acatagcaga actttaaaag tgctcatcat 3180
tggaaaacgt tcttcggggc gaaaactctc aaggatctta ccgctgttga gatccagttc 3240
gatgtaaccc actcgtgcac ccaactgatc ttcagcatct tttactttca ccagcgtttc 3300
tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg cgacacggaa 3360
atgttgaata ctcatactct tcctttttca atcatgattg aagcatttat cagggttatt 3420
gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata ggtcatgacc 3480
aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa 3540
ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca 3600
ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta 3660
actggcttca gcagagcgca gataccaaat actgtccttc tagtgtagcc gtagttaggc 3720
caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca 3780
gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta 3840
ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag 3900
cgaacgacct acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt 3960
cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc 4020
acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac 4080
ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac 4140
gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgttc 4200
tttcctgcgt tatcccctga ttctgtggat aaccgtatta ccgcctttga gtgagctgat 4260
accgctcgcc gcagccgaac gaccgagcgc agcgagtcag tgagcgagga agcggaagag 4320
cgcctgatgc ggtattttct ccttacgcat ctgtgcggta tttcacaccg catatatggt 4380
gcactctcag tacaatctgc tctgatgccg catagttaag ccagtataca ctccgctatc 4440
gctacgtgac tgggtcatgg ctgcgccccg acacccgcca acacccgctg acgcgccctg 4500
acgggcttgt ctgctcccgg catccgctta cagacaagct gtgaccgtct ccgggagctg 4560
catgtgtcag aggttttcac cgtcatcacc gaaacgcgcg aggcagctgc ggtaaagctc 4620
atcagcgtgg tcgtgaagcg attcacagat gtctgcctgt tcatccgcgt ccagctcgtt 4680
gagtttctcc agaagcgtta atgtctggct tctgataaag cgggccatgt taagggcggt 4740
tttttcctgt ttggtcactg atgcctccgt gtaaggggga tttctgttca tgggggtaat 4800
gataccgatg aaacgagaga ggatgctcac gatacgggtt actgatgatg aacatgcccg 4860
gttactggaa cgttgtgagg gtaaacaact ggcggtatgg atgcggcggg accagagaaa 4920
aatcactcag ggtcaatgcc agcgcttcgt taatacagat gtaggtgttc cacagggtag 4980
ccagcagcat cctgcgatgc agatccggaa cataatggtg cagggcgctg acttccgcgt 5040
ttccagactt tacgaaacac ggaaaccgaa gaccattcat gttgttgctc aggtcgcaga 5100
cgttttgcag cagcagtcgc ttcacgttcg ctcgcgtatc ggtgattcat tctgctaacc 5160
agtaaggcaa ccccgccagc ctagccgggt cctcaacgac aggagcacga tcatgctagt 5220
catgccccgc gcccaccgga aggagctgac tgggttgaag gctctcaagg gcatcggtcg 5280
agatcccggt gcctaatgag tgagctaact tacattaatt gcgttgcgct cactgcccgc 5340
tttccagtcg ggaaacctgt cgtgccagct gcattaatga atcggccaac gcgcggggag 5400
aggcggtttg cgtattgggc gccagggtgg tttttctttt caccagtgag acgggcaaca 5460
gctgattgcc cttcaccgcc tggccctgag agagttgcag caagcggtcc acgctggttt 5520
gccccagcag gcgaaaatcc tgtttgatgg tggttaacgg cgggatataa catgagctgt 5580
cttcggtatc gtcgtatccc actaccgaga tgtccgcacc aacgcgcagc ccggactcgg 5640
taatggcgcg cattgcgccc agcgccatct gatcgttggc aaccagcatc gcagtgggaa 5700
cgatgccctc attcagcatt tgcatggttt gttgaaaacc ggacatggca ctccagtcgc 5760
cttcccgttc cgctatcggc tgaatttgat tgcgagtgag atatttatgc cagccagcca 5820
gacgcagacg cgccgagaca gaacttaatg ggcccgctaa cagcgcgatt tgctggtgac 5880
ccaatgcgac cagatgctcc acgcccagtc gcgtaccgtc ttcatgggag aaaataatac 5940
tgttgatggg tgtctggtca gagacatcaa gaaataacgc cggaacatta gtgcaggcag 6000
cttccacagc aatggcatcc tggtcatcca gcggatagtt aatgatcagc ccactgacgc 6060
gttgcgcgag aagattgtgc accgccgctt tacaggcttc gacgccgctt cgttctacca 6120
tcgacaccac cacgctggca cccagttgat cggcgcgaga tttaatcgcc gcgacaattt 6180
gcgacggcgc gtgcagggcc agactggagg tggcaacgcc aatcagcaac gactgtttgc 6240
ccgccagttg ttgtgccacg cggttgggaa tgtaattcag ctccgccatc gccgcttcca 6300
ctttttcccg cgttttcgca gaaacgtggc tggcctggtt caccacgcgg gaaacggtct 6360
gataagagac accggcatac tctgcgacat cgtataacgt tactggtttc acattcacca 6420
ccctgaattg actctcttcc gggcgctatc atgccatacc gcgaaaggtt ttgcgccatt 6480
cgatggtgtc cgggatctcg acgctctccc ttatgcgact cctgcattag gaagcagccc 6540
agtagtaggt tgaggccgtt gagcaccgcc gccgcaagga atggtgcatg caaggagatg 6600
gcgcccaaca gtcccccggc cacggggcct gccaccatac ccacgccgaa acaagcgctc 6660
atgagcccga agtggcgagc ccgatcttcc ccatcggtga tgtcggcgat ataggcgcca 6720
gcaaccgcac ctgtggcgcc ggtgatgccg gccacgatgc gtccggcgta gaggatcgag 6780
atcgatctcg atcccgcgaa attaatacga ctcactata                        6819


<210> 125
<211> 58
<212> DNA
<213> Artificial Sequence

<220> 
<223> VHSfi-R Primer

<400> 125
ccatggtgat ggtgatggtg ctggccggcc tggcccggag aaacggtaac aacggtac   58

<210> 126
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> AgeI-F Primer

<400> 126
ccctgaaaac cggtgttccg tctc                                        24

<210> 127
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Cys19-R Primer

<400> 127
caccgcaaga caggcacaga gaaccaccag                                  30

<210> 128
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Cys19-F Primer
      

<400> 128
ctggtggttc tctgtgcctg tcttgcggtg                                  30

<210> 129
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> NcoI25-R Primer

<400> 129
ggtatgcgcc atggtgatgg tgatg                                       25

<210> 130
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> HingeVH- R Primer

<400> 130
cgcagctttt cggcggagaa acggtaacaa cggtac                           36

<210> 131
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> VHhinge-F Primer

<400> 131
ccgtttctcc gccgaaaagc tgcgataaaa cccatacctg cc                    42

<210> 132
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> HingeTemplate-F Primer

<400> 132
gctgcgataa aacccatacc tgcccgccgt gcccgggcca g                     41

<210> 133
<211> 44
<212> DNA
<213> Artificial Sequence

<220> 
<223> HingeTemplate-R Primer

<400> 133
gatggtgatg gtgctggccg gcctggcccg ggcacggcgg gcag                  44

<210> 134
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> NcoI38-R Primer

<400> 134
gcggcgccat ggtgatggtg atggtgctgg ccggcctg                         38

<210> 135
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> HingeVH(E)-R Primer

<400> 135
cgcagctttt cggttccgga gaaacggtaa caacggtacc cggac                 45

<210> 136
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> VHhinge(E)-F Primer

<400> 136
ccgtttctcc ggaaccgaaa agctgcgata aaacccatac ctgcc                 45

<210> 137
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> NdeIVH-F Primer

<400> 137
ggagatatac atatgaaata cctattgcct ac                               32

<210> 138
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> XhoIHA26-R Primer

<400> 138
taccagactc gagctaagaa gcgtag                                      26

<210> 139
<211> 44
<212> DNA
<213> Artificial Sequence

<220> 
<223> HingeCH1-R Primer

<400> 139
caggtatggg ttttatcgca gcttttcggt tcaactttct tgtc                  44

<210> 140
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> CH1Hinge-F Primer

<400> 140
ccgaaaagct gcgataaaac ccatacctgc ccgccgtgc                        39

<210> 141
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> HingeHisTemplate-F Primer

<400> 141
cccatacctg cccgccgtgc ccgcaccatc accatcacca tggcg                 45

<210> 142
<211> 47
<212> DNA
<213> Artificial Sequence

<220> 
<223> HingeHisTemplate-R Primer

<400> 142
gtccggaacg tcgtacgggt atgcgccatg gtgatggtga tggtgcg               47

<210> 143
<211> 47
<212> DNA
<213> Artificial Sequence

<220> 
<223> XhoIHA-R Primer

<400> 143
accagactcg agctaagaag cgtagtccgg aacgtcgtac gggtatg               47

<210> 144
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> XbaIVL-F Primer

<400> 144
ggggaattgt gagcggataa caattc                                      26

<210> 145
<211> 51
<212> DNA
<213> Artificial Sequence

<220> 
<223> BamHICK-R Primer

<400> 145
ccgccaccgg atccaccacc agattcacca cggttgaaag atttggtaac c          51

<210> 146
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> SacIVH-F Primer

<400> 146
gcggtgggag ctccggtgaa gttcagctgg ttgaatctgg tg                    42

<210> 147
<211> 51
<212> DNA
<213> Artificial Sequence

<220> 
<223> HingeCH1deltaC-R Primer

<400> 147
ctggccggcc tggccgctgc tgccagattt cggttcaact ttcttgtcaa c          51

<210> 148
<211> 46
<212> DNA
<213> Artificial Sequence

<220> 
<223> NcoIHinge-R Primer

<400> 148
gtatgcgcca tggtgatggt gatggtgctg gccggcctgg ccgctg                46

<210> 149
<211> 79
<212> DNA
<213> Artificial Sequence

<220> 
<223> SacIBamHI(-)

<400> 149
cccaccgcta ccgccgcctt cgctgccgcc accttcgcta ccgccacctt cgctgccacc 60
accttcgctg ccgccaccg                                              79

<210> 150
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> L216F Primer

<400> 150
gatccggcag cagcagcagc ggcggcggga gct                              33

<210> 151
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> L216R Primer

<400> 151
cccgccgccg ctgctgctgc tgccg                                       25

<210> 152
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> L217F Primer

<400> 152
gatccggcag cagcagcagc ggcggcggcg ggagct                           36

<210> 153
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> L217R Primer

<400> 153
cccgccgccg ccgctgctgc tgctgccg                                    28

<210> 154
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> L219F Primer

<400> 154
gatccagcgg cagcagcagc agcggcggcg gcggcgggag ct                    42

<210> 155
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> L219R Primer

<400> 155
cccgccgccg ccgccgctgc tgctgctgcc gctg                             34

<210> 156
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> L220F Primer

<400> 156
gatccagcgg cggcagcagc agcagcggcg gcggcggcgg gagct                 45

<210> 157
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> L220R Primer

<400> 157
cccgccgccg ccgccgctgc tgctgctgcc gccgctg                          37

<210> 158
<211> 225
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 Fab VH-CH1

<400> 158
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
 1               5                  10                  15      
Ser Leu Ile Leu Ser Cys Gly Val Ser Asn Phe Arg Ile Ser Ala His
            20                  25                  30          
Thr Met Asn Trp Val Arg Arg Val Pro Gly Gly Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Leu Glu Asp Phe Val Tyr
65                  70                  75                  80  
Leu Gln Met His Lys Met Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Gly Ser Asp Arg Leu Ser Asp Asn Asp Pro Phe Asp Ala
            100                 105                 110         
Trp Gly Pro Gly Thr Val Val Thr Val Ser Pro Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
    210                 215                 220                 
Ser
225 

   
<210> 159
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 Light Chain

<400> 159
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ala Gly Tyr Ser Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 160
<211> 3
<212> RNA
<213> Artificial Sequence

<220> 
<223> amber stop RNA

<400> 160
uag                                                               3

<210> 161
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> 3-ALA 2G12 VH domain

<400> 161
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
 1               5                  10                  15      
Ser Leu Ile Leu Ser Cys Gly Val Ser Asn Phe Arg Ile Ser Ala His
            20                  25                  30          
Thr Met Asn Trp Val Arg Arg Val Pro Gly Gly Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Leu Glu Asp Phe Val Tyr
65                  70                  75                  80  
Leu Gln Met His Lys Met Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Gly Ser Asp Arg Ala Ala Asp Ala Asp Pro Phe Asp Ala
            100                 105                 110         
Trp Gly Pro Gly Thr Val Val Thr Val Ser Pro
        115                 120             


<210> 162
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 CDRL3

<400> 162
Gln His Tyr Ala Gly Tyr Ser Ala Thr
 1               5                  


<210> 163
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 3-ALA 2G12 CDRL3

<400> 163
Gln His Ala Ala Gly Ala Ala Ala Thr
 1               5                  


<210> 164
<211> 5882
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 3-ALA pCAL IT* (contains 3Ala CDRH3)

<400> 164
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt 180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt 240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt 300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg 360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga 420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa 480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga 540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa 600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca 660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta 720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac 780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc 840
gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag 900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga 960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt 1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata 1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag 1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa 1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt 1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc 1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa 1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa 1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc 1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa 1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa 1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg 1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc 1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg 1800
ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg 1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg 1920
aagcgacacc atcgaatggc gcaaaacctt tcgcggtatg gcatgatagc gcccggaaga 1980
gagtcaattc agggtggtga atgtgaaacc agtaacgtta tacgatgtcg cagagtatgc 2040
cggtgtctct tatcagaccg tttcccgcgt ggtgaaccag gccagccacg tttctgcgaa 2100
aacgcgggaa aaagtggaag cggcgatggc ggagctgaat tacattccca accgcgtggc 2160
acaacaactg gcgggcaaac agtcgttgct gattggcgtt gccacctcca gtctggccct 2220
gcacgcgccg tcgcaaattg tcgcggcgat taaatctcgc gccgatcaac tgggtgccag 2280
cgtggtggtg tcgatggtag aacgaagcgg cgtcgaagcc tgtaaagcgg cggtgcacaa 2340
tcttctcgcg caacgcgtca gtgggctgat cattaactat ccgctggatg accaggatgc 2400
cattgctgtg gaagctgcct gcactaatgt tccggcgtta tttcttgatg tctctgacca 2460
gacacccatc aacagtatta ttttctccca tgaagacggt acgcgactgg gcgtggagca 2520
tctggtcgca ttgggtcacc agcaaatcgc gctgttagcg ggcccattaa gttctgtctc 2580
ggcgcgtctg cgtctggctg gctggcataa atatctcact cgcaatcaaa ttcagccgat 2640
agcggaacgg gaaggcgact ggagtgccat gtccggtttt caacaaacca tgcaaatgct 2700
gaatgagggc atcgttccca ctgcgatgct ggttgccaac gatcagatgg cgctgggcgc 2760
aatgcgcgcc attaccgagt ccgggctgcg cgttggtgcg gatatctcgg tagtgggata 2820
cgacgatacc gaagacagct catgttatat cccgccgtta accaccatca aacaggattt 2880
tcgcctgctg gggcaaacca gcgtggaccg cttgctgcaa ctctctcagg gccaggcggt 2940
gaagggcaat cagctgttgc ccgtctcact ggtgaaaaga aaaaccaccc tggcgcccaa 3000
tacgcaaacc gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt 3060
ttcccgactg gaaagcgggc agtgagcggt acccgataaa agcggcttcc tgacaggagg 3120
ccgttttgtt ttgcagccca cctcaacgca attaatgtga gttagctcac tcattaggca 3180
ccccaggctt tacactttat gcttccggct cgtatgttgt gtggaattgt gagcggataa 3240
caattgaatt aaggaggata taattatgaa atacctgctg ccgaccgcag ccgctggtct 3300
gctgctgctc gcggcctagc cggccatggc cgccggtgtt gttatgaccc agtctccgtc 3360
taccctgtct gcttctgttg gtgacaccat caccatcacc tgccgtgctt ctcagtctat 3420
cgaaacctgg ctggcttggt accagcagaa accgggtaaa gctccgaaac tgctgatcta 3480
caaggcttct accctgaaaa ccggtgttcc gtctcgtttc tctggttctg gttctggtac 3540
cgagttcacc ctgaccatct ctggtctgca gttcgacgac ttcgctacct accactgcca 3600
gcactacgct ggttactctg ctaccttcgg tcagggtacc cgtgttgaaa tcaaacgtac 3660
cgttgctgct ccgtctgttt tcatcttccc gccgtctgac gaacagctga aatctggtac 3720
cgcttctgtt gtttgcctgc tgaacaactt ctacccgcgt gaagctaaag ttcagtggaa 3780
agttgacaac gctctgcagt ctggtaactc tcaggaatct gttaccgaac aggactctaa 3840
agactctacc tactctctgt cttctaccct gaccctgtct aaagctgact acgaaaagca 3900
caaagtttac gcttgcgaag ttacccacca gggtctgtct tctccggtta ccaaatcttt 3960
caaccgtggt gaatgctaat taattaataa ggaggatata attatgaaaa agacagctat 4020
cgcgattgca gtggcactgg ctggtttcgc taccgtagcc taggcggccg cagaagttca 4080
gctggttgaa tctggtggtg gtctggttaa agctggtggt tctctgatcc tgtcttgcgg 4140
tgtttctaac ttccgtatct ctgctcacac catgaactgg gttcgtcgtg ttccgggtgg 4200
tggtctggaa tgggttgctt ctatctctac ctcttctacc taccgtgact acgctgacgc 4260
tgttaaaggt cgtttcaccg tttctcgtga cgacctggaa gacttcgttt acctgcagat 4320
gcataaaatg cgtgttgaag acaccgctat ctactactgc gctcgtaaag gttctgaccg 4380
tgcggcggac gcggacccgt tcgacgcttg gggtccgggt accgttgtta ccgtttctcc 4440
ggcgtcgacc aaaggtccgt ctgttttccc gctggctccg tcttctaaat ctacctctgg 4500
tggtaccgct gctctgggtt gcctggttaa agactacttc ccggaaccgg ttaccgtttc 4560
ttggaactct ggtgctctga cctctggtgt tcacaccttc ccggctgttc tgcagtcttc 4620
tggtctgtac tctctgtctt ctgttgttac cgttccgtct tcttctctgg gtacccagac 4680
ctacatctgc aacgttaacc acaaaccgtc taacaccaaa gttgacaaga aagttgaacc 4740
gaaatcttgc ctgcgatcgc ggccaggccg gccgcaccat caccatcacc atggcgcata 4800
cccgtacgac gttccggact acgcttctac tagttaggag ggtggtggct ctgagggtgg 4860
cggttctgag ggtggcggct ctgagggagg cggttccggt ggtggctctg gttccggtga 4920
ttttgattat gaaaagatgg caaacgctaa taagggggct atgaccgaaa atgccgatga 4980
aaacgcgcta cagtctgacg ctaaaggcaa acttgattct gtcgctactg attacggtgc 5040
tgctatcgat ggtttcattg gtgacgtttc cggccttgct aatggtaatg gtgctactgg 5100
tgattttgct ggctctaatt cccaaatggc tcaagtcggt gacggtgata attcaccttt 5160
aatgaataat ttccgtcaat atttaccttc cctccctcaa tcggttgaat gtcgcccttt 5220
tgtctttggc gctggtaaac catatgaatt ttctattgat tgtgacaaaa taaacttatt 5280
ccgtggtgtc tttgcgtttc ttttatatgt tgccaccttt atgtatgtat tttctacgtt 5340
tgctaacata ctgcgtaata aggagtctta agctagctaa cgatcgccct tcccaacagt 5400
tgcgcagcct gaatggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg 5460
tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg 5520
ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg 5580
ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt 5640
agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt 5700
tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta 5760
tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa 5820
atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg cttacaattt 5880
ag                                                                5882

<210> 165
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12LCF primer

<400> 165
gccgctgtgc catcgctcag taacaattga attaaggagg a                     41

<210> 166
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> L3R primer

<400> 166
atagtgctgg cagtggtagg                                             20

<210> 167
<211> 55
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 reference sequence

<400> 167
ctacctacca ctgccagcac tacgctggtt actctgctac cttcggtcag ggtac      55

<210> 168
<211> 55
<212> DNA
<213> Artificial Sequence

<220> 
<223> AGYS primer

<220> 
<221> variation      
<222> 24-25, 27-28, 30-31, 33-34
<223> n = a, g, c or t

<220> 
<221> variation      
<222> 26, 29, 32, 35
<223> k = g or t

<400> 168
ctacctacca ctgccagcac tatnnknnkn nknnkgctac cttcggtcag ggtac      55

<210> 169
<211> 58
<212> DNA
<213> Artificial Sequence

<220> 
<223> AGYS+1 primer

<220> 
<221> variation      
<222> 24-25, 27-28, 30-31, 33-34, 36-37
<223> n = a, c, g or t

<220> 
<221> variation      
<222> 26, 29, 32, 35, 38
<223> k = g or t

<400> 169
ctacctacca ctgccagcac tatnnknnkn nknnknnkgc taccttcggt cagggtac   58

<210> 170
<211> 61
<212> DNA
<213> Artificial Sequence

<220> 
<223> AGYS+2 primer

<220> 
<221> variation      
<222> 24-25, 27-28, 30-31, 33-34, 36-37, 39-40
<223> n = a, c, t, or g

<220> 
<221> variation      
<222> 26, 29, 32, 35, 38, 41
<223> k = g or t

<400> 170
ctacctacca ctgccagcac tatnnknnkn nknnknnknn kgctaccttc ggtcagggta 60
c                                                                 61

<210> 171
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12LCR primer

<400> 171
gccgctgtgc catcgctcag taacttaatt aattagcatt caccacgg              48

<210> 172
<211> 6
<212> DNA
<213> Artificial Sequence

<220> 
<223> MfeI restriction site

<400> 172
caattg                                                            6

<210> 173
<211> 8
<212> DNA
<213> Artificial Sequence

<220> 
<223> PacI restriction site

<400> 173
ttaattaa                                                          8

<210> 174
<211> 5882
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 3ALA LC pCAL IT* (contains 3-Ala CDRL3)

<400> 174
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt 180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt 240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt 300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg 360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga 420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa 480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga 540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa 600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca 660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta 720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac 780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc 840
gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag 900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga 960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt 1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata 1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag 1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa 1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt 1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc 1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa 1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa 1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc 1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa 1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa 1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg 1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc 1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg 1800
ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg 1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg 1920
aagcgacacc atcgaatggc gcaaaacctt tcgcggtatg gcatgatagc gcccggaaga 1980
gagtcaattc agggtggtga atgtgaaacc agtaacgtta tacgatgtcg cagagtatgc 2040
cggtgtctct tatcagaccg tttcccgcgt ggtgaaccag gccagccacg tttctgcgaa 2100
aacgcgggaa aaagtggaag cggcgatggc ggagctgaat tacattccca accgcgtggc 2160
acaacaactg gcgggcaaac agtcgttgct gattggcgtt gccacctcca gtctggccct 2220
gcacgcgccg tcgcaaattg tcgcggcgat taaatctcgc gccgatcaac tgggtgccag 2280
cgtggtggtg tcgatggtag aacgaagcgg cgtcgaagcc tgtaaagcgg cggtgcacaa 2340
tcttctcgcg caacgcgtca gtgggctgat cattaactat ccgctggatg accaggatgc 2400
cattgctgtg gaagctgcct gcactaatgt tccggcgtta tttcttgatg tctctgacca 2460
gacacccatc aacagtatta ttttctccca tgaagacggt acgcgactgg gcgtggagca 2520
tctggtcgca ttgggtcacc agcaaatcgc gctgttagcg ggcccattaa gttctgtctc 2580
ggcgcgtctg cgtctggctg gctggcataa atatctcact cgcaatcaaa ttcagccgat 2640
agcggaacgg gaaggcgact ggagtgccat gtccggtttt caacaaacca tgcaaatgct 2700
gaatgagggc atcgttccca ctgcgatgct ggttgccaac gatcagatgg cgctgggcgc 2760
aatgcgcgcc attaccgagt ccgggctgcg cgttggtgcg gatatctcgg tagtgggata 2820
cgacgatacc gaagacagct catgttatat cccgccgtta accaccatca aacaggattt 2880
tcgcctgctg gggcaaacca gcgtggaccg cttgctgcaa ctctctcagg gccaggcggt 2940
gaagggcaat cagctgttgc ccgtctcact ggtgaaaaga aaaaccaccc tggcgcccaa 3000
tacgcaaacc gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt 3060
ttcccgactg gaaagcgggc agtgagcggt acccgataaa agcggcttcc tgacaggagg 3120
ccgttttgtt ttgcagccca cctcaacgca attaatgtga gttagctcac tcattaggca 3180
ccccaggctt tacactttat gcttccggct cgtatgttgt gtggaattgt gagcggataa 3240
caattgaatt aaggaggata taattatgaa atacctgctg ccgaccgcag ccgctggtct 3300
gctgctgctc gcggcctagc cggccatggc cgccggtgtt gttatgaccc agtctccgtc 3360
taccctgtct gcttctgttg gtgacaccat caccatcacc tgccgtgctt ctcagtctat 3420
cgaaacctgg ctggcttggt accagcagaa accgggtaaa gctccgaaac tgctgatcta 3480
caaggcttct accctgaaaa ccggtgttcc gtctcgtttc tctggttctg gttctggtac 3540
cgagttcacc ctgaccatct ctggtctgca gttcgacgac ttcgctacct accactgcca 3600
gcacgccgcg ggtgcggccg cgaccttcgg tcagggtacc cgtgttgaaa tcaaacgtac 3660
cgttgctgct ccgtctgttt tcatcttccc gccgtctgac gaacagctga aatctggtac 3720
cgcttctgtt gtttgcctgc tgaacaactt ctacccgcgt gaagctaaag ttcagtggaa 3780
agttgacaac gctctgcagt ctggtaactc tcaggaatct gttaccgaac aggactctaa 3840
agactctacc tactctctgt cttctaccct gaccctgtct aaagctgact acgaaaagca 3900
caaagtttac gcttgcgaag ttacccacca gggtctgtct tctccggtta ccaaatcttt 3960
caaccgtggt gaatgctaat taattaataa ggaggatata attatgaaaa agacagctat 4020
cgcgattgca gtggcactgg ctggtttcgc taccgtagcc taggcggccg cagaagttca 4080
gctggttgaa tctggtggtg gtctggttaa agctggtggt tctctgatcc tgtcttgcgg 4140
tgtttctaac ttccgtatct ctgctcacac catgaactgg gttcgtcgtg ttccgggtgg 4200
tggtctggaa tgggttgctt ctatctctac ctcttctacc taccgtgact acgctgacgc 4260
tgttaaaggt cgtttcaccg tttctcgtga cgacctggaa gacttcgttt acctgcagat 4320
gcataaaatg cgtgttgaag acaccgctat ctactactgc gctcgtaaag gttctgaccg 4380
tctgtctgac aacgacccgt tcgacgcttg gggtccgggt accgttgtta ccgtttctcc 4440
ggcgtcgacc aaaggtccgt ctgttttccc gctggctccg tcttctaaat ctacctctgg 4500
tggtaccgct gctctgggtt gcctggttaa agactacttc ccggaaccgg ttaccgtttc 4560
ttggaactct ggtgctctga cctctggtgt tcacaccttc ccggctgttc tgcagtcttc 4620
tggtctgtac tctctgtctt ctgttgttac cgttccgtct tcttctctgg gtacccagac 4680
ctacatctgc aacgttaacc acaaaccgtc taacaccaaa gttgacaaga aagttgaacc 4740
gaaatcttgc ctgcgatcgc ggccaggccg gccgcaccat caccatcacc atggcgcata 4800
cccgtacgac gttccggact acgcttctac tagttaggag ggtggtggct ctgagggtgg 4860
cggttctgag ggtggcggct ctgagggagg cggttccggt ggtggctctg gttccggtga 4920
ttttgattat gaaaagatgg caaacgctaa taagggggct atgaccgaaa atgccgatga 4980
aaacgcgcta cagtctgacg ctaaaggcaa acttgattct gtcgctactg attacggtgc 5040
tgctatcgat ggtttcattg gtgacgtttc cggccttgct aatggtaatg gtgctactgg 5100
tgattttgct ggctctaatt cccaaatggc tcaagtcggt gacggtgata attcaccttt 5160
aatgaataat ttccgtcaat atttaccttc cctccctcaa tcggttgaat gtcgcccttt 5220
tgtctttggc gctggtaaac catatgaatt ttctattgat tgtgacaaaa taaacttatt 5280
ccgtggtgtc tttgcgtttc ttttatatgt tgccaccttt atgtatgtat tttctacgtt 5340
tgctaacata ctgcgtaata aggagtctta agctagctaa cgatcgccct tcccaacagt 5400
tgcgcagcct gaatggcgaa tgggacgcgc cctgtagcgg cgcattaagc gcggcgggtg 5460
tggtggttac gcgcagcgtg accgctacac ttgccagcgc cctagcgccc gctcctttcg 5520
ctttcttccc ttcctttctc gccacgttcg ccggctttcc ccgtcaagct ctaaatcggg 5580
ggctcccttt agggttccga tttagtgctt tacggcacct cgaccccaaa aaacttgatt 5640
agggtgatgg ttcacgtagt gggccatcgc cctgatagac ggtttttcgc cctttgacgt 5700
tggagtccac gttctttaat agtggactct tgttccaaac tggaacaaca ctcaacccta 5760
tctcggtcta ttcttttgat ttataaggga ttttgccgat ttcggcctat tggttaaaaa 5820
atgagctgat ttaacaaaaa tttaacgcga attttaacaa aatattaacg cttacaattt 5880
ag                                                                5882

<210> 175
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> L1R primer

<400> 175
gggcggcgct cttcgtagcg aagtcgtcga actg                             34

<210> 176
<211> 55
<212> DNA
<213> Artificial Sequence

<220> 
<223> SYGA primer

<220> 
<221> variation      
<222> 25-26, 28-29, 31-32, 34-35
<223> n = a, c, g or t

<220> 
<221> variation      
<222> 24, 27, 30, 33
<223> m = a or c

<400> 176
cgggtaccct gaccgaaggt agcmnnmnnm nnmnnatagt gctggcagtg gtagg      55

<210> 177
<211> 58
<212> DNA
<213> Artificial Sequence

<220> 
<223> SYGA+1 primer

<220> 
<221> variation      
<222> 25-26, 28-29, 31-32, 34-35, 37-38
<223> n = a, c, t, or g

<220> 
<221> variation      
<222> 24, 27, 30, 33, 36
<223> m = a or c

<400> 177
cgggtaccct gaccgaaggt agcmnnmnnm nnmnnmnnat agtgctggca gtggtagg   58

<210> 178
<211> 61
<212> DNA
<213> Artificial Sequence

<220> 
<223> SYGA+2 primer

<220> 
<221> variation      
<222> 25-26, 28-29, 31-32, 34-35, 37-38, 40-41
<223> n = a, c, t or g

<220> 
<221> variation      
<222> 24, 27, 30, 33, 36, 39
<223> m = a or c

<400> 178
cgggtaccct gaccgaaggt agcmnnmnnm nnmnnmnnmn natagtgctg gcagtggtag 60
g                                                                 61

<210> 179
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> L2F primer

<400> 179
gggcggcgct cttccccgtg ttgaaatcaa acgt                             34

<210> 180
<211> 7
<212> DNA
<213> Artificial Sequence

<220> 
<223> SapI restriction site

<400> 180
gctcttc                                                           7

<210> 181
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 181
Gln His Tyr Lys Glu Trp Arg Ala Ser
 1               5                  


<210> 182
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 182
Gln His Tyr Lys Glu Trp Ser Ala Thr
 1               5                  


<210> 183
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 183
Gln His Tyr Arg Glu Trp Ser Ala Thr
 1               5                  


<210> 184
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 184
Gln His Tyr Leu Ala Trp Ser Ala Thr
 1               5                  


<210> 185
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 185
Gln His Tyr Lys Glu Trp Trp Ala Thr
 1               5                  


<210> 186
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 186
Gln His Tyr Arg Glu Trp Trp Ala Thr
 1               5                  


<210> 187
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 187
Gln His Tyr Leu Ser Trp Ser Ala Thr
 1               5                  


<210> 188
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 188
Gln His Tyr Lys Pro Phe Asn Ala Thr
 1               5                  


<210> 189
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 189
Gln His Tyr Arg Pro Phe Asn Ala Thr
 1               5                  


<210> 190
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 190
Gln His Tyr Met Pro Phe Asn Ala Thr
 1               5                  


<210> 191
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 191
Gln His Tyr Gln Pro Phe Asn Ala Thr
 1               5                  


<210> 192
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 192
Gln His Tyr Leu Pro Phe Asn Ala Thr
 1               5                  


<210> 193
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 193
Gln His Tyr Glu Pro Phe Asn Ala Thr
 1               5                  


<210> 194
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 194
Gln His Tyr Lys Pro Phe Glu Ala Thr
 1               5                  


<210> 195
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 195
Gln His Tyr Arg Pro Phe Glu Ala Thr
 1               5                  


<210> 196
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 196
Gln His Tyr Lys Pro Phe Gln Ala Thr
 1               5                  


<210> 197
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 197
Gln His Tyr Arg Pro Phe Gln Ala Thr
 1               5                  


<210> 198
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 198
Gln His Tyr Gln Pro Phe Gln Ala Thr
 1               5                  


<210> 199
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 199
Gln His Tyr Ile Pro Phe Gln Ala Thr
 1               5                  


<210> 200
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 200
Gln His Tyr Lys Pro Phe Ser Ala Ser
 1               5                  


<210> 201
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 201
Gln His Tyr Arg Pro Phe Ser Ala Thr
 1               5                  


<210> 202
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 202
Gln His Tyr Gln Pro Phe Ser Ala Thr
 1               5                  


<210> 203
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 203
Gln His Tyr Val Pro Phe Ser Ala Thr
 1               5                  


<210> 204
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 204
Gln His Tyr His Pro Phe Ser Ala Thr
 1               5                  


<210> 205
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 205
Gln His Tyr Lys Pro Phe His Ala Thr
 1               5                  


<210> 206
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 206
Gln His Tyr Arg Pro Phe His Ala Thr
 1               5                  


<210> 207
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 207
Gln His Tyr Met Pro Phe His Ala Thr
 1               5                  


<210> 208
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 208
Gln His Tyr Glu Pro Phe His Ala Thr
 1               5                  


<210> 209
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 209
Gln His Tyr Lys Pro Phe Arg Ala Thr
 1               5                  


<210> 210
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 210
Gln His Tyr Val Pro Phe Arg Ala Thr
 1               5                  


<210> 211
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 211
Gln His Tyr Glu Pro Phe Arg Ala Thr
 1               5                  


<210> 212
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 212
Gln His Tyr Lys Pro Phe Ala Ala Thr
 1               5                  


<210> 213
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 213
Gln His Tyr Val Pro Phe Ala Ala Thr
 1               5                  


<210> 214
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 214
Gln His Tyr Ile Pro Phe Ala Ala Thr
 1               5                  


<210> 215
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 215
Gln His Tyr Lys Pro Phe Asp Ala Thr
 1               5                  


<210> 216
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 216
Gln His Tyr Met Pro Phe Asp Ala Thr
 1               5                  


<210> 217
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 217
Gln His Tyr Met Pro Phe Lys Ala Thr
 1               5                  


<210> 218
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 218
Gln His Tyr Met Pro Phe Thr Ala Thr
 1               5                  


<210> 219
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 219
Gln His Tyr Met Pro Phe Pro Ala Thr
 1               5                  


<210> 220
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 220
Gln His Tyr Gln Pro Phe Trp Ala Thr
 1               5                  


<210> 221
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 221
Gln His Tyr Ser Pro Phe Trp Ala Thr
 1               5                  


<210> 222
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 222
Gln His Tyr Met Pro Tyr Arg Ala Ser
 1               5                  


<210> 223
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 223
Gln His Tyr Lys Pro Tyr Arg Ala Thr
 1               5                  


<210> 224
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 224
Gln His Tyr Met Pro Tyr Arg Ala Thr
 1               5                  


<210> 225
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 225
Gln His Tyr Gln Pro Tyr Arg Ala Thr
 1               5                  


<210> 226
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 226
Gln His Tyr Leu Pro Tyr Arg Ala Thr
 1               5                  


<210> 227
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 227
Gln His Tyr Glu Pro Tyr Arg Ala Thr
 1               5                  


<210> 228
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 228
Gln His Tyr Lys Pro Tyr Asp Ala Thr
 1               5                  


<210> 229
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 229
Gln His Tyr Lys Pro Tyr Ser Ala Thr
 1               5                  


<210> 230
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 230
Gln His Tyr Gln Pro Tyr Val Ala Thr
 1               5                  


<210> 231
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 231
Gln His Tyr Glu Pro Tyr Lys Ala Thr
 1               5                  


<210> 232
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 232
Gln His Tyr Leu Pro Tyr Gln Ala Ser
 1               5                  


<210> 233
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 233
Gln His Tyr Arg Pro His Thr Gly Ala Thr
 1               5                  10  


<210> 234
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 234
Gln His Tyr Thr Ala His Asp Gly Ala Thr
 1               5                  10  


<210> 235
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 235
Gln His Tyr Thr Ala His Arg Gly Ala Thr
 1               5                  10  


<210> 236
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 236
Gln His Tyr Arg Ala His Thr Gly Ala Thr
 1               5                  10  


<210> 237
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 237
Gln His Tyr Thr Ala His Thr Gly Ala Thr
 1               5                  10  


<210> 238
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 238
Gln His Tyr Thr Asp His His Gly Ala Thr
 1               5                  10  


<210> 239
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 239
Gln His Tyr Thr Asp His Lys Gly Ala Thr
 1               5                  10  


<210> 240
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 240
Gln His Tyr Thr Asp His Arg Gly Ala Thr
 1               5                  10  


<210> 241
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 variant CDRL3

<400> 241
Gln His Tyr Thr Asp His Tyr Gly Ala Thr
 1               5                  10  


<210> 242
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 242
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Glu Trp Arg
                85                  90                  95      
Ala Ser Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 243
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 243
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Glu Trp Ser
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 244
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 244
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Glu Trp Ser
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 245
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 245
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Leu Ala Trp Ser
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 246
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 246
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Glu Trp Trp
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 247
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 247
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Glu Trp Trp
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 248
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 248
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Leu Ser Trp Ser
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 249
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 249
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Phe Asn
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 250
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 250
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Pro Phe Asn
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 251
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 251
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Pro Phe Asn
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 252
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 252
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Gln Pro Phe Asn
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 253
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 253
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Leu Pro Phe Asn
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 254
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 254
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Glu Pro Phe Asn
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 255
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 255
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Phe Glu
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 256
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 256
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Pro Phe Glu
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 257
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 257
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Phe Gln
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 258
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 258
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Pro Phe Gln
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 259
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 259
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Gln Pro Phe Gln
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 260
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 260
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ile Pro Phe Gln
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 261
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 261
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Phe Ser
                85                  90                  95      
Ala Ser Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 262
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 262
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Pro Phe Ser
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 263
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 263
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Gln Pro Phe Ser
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 264
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 264
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Val Pro Phe Ser
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 265
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 265
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr His Pro Phe Ser
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 266
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 266
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Phe His
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 267
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 267
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Pro Phe His
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 268
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 268
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Pro Phe His
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 269
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 269
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Glu Pro Phe His
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 270
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 270
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Phe Arg
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 271
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 271
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Val Pro Phe Arg
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 272
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 272
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Glu Pro Phe Arg
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 273
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 273
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Phe Ala
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 274
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 274
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Val Pro Phe Ala
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 275
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 275
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ile Pro Phe Ala
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 276
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 276
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Phe Asp
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 277
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 277
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Pro Phe Asp
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 278
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 278
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Pro Phe Lys
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 279
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 279
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Pro Phe Thr
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 280
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 280
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Pro Phe Pro
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 281
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 281
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Gln Pro Phe Trp
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 282
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 282
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Ser Pro Phe Trp
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 283
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 283
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Pro Tyr Arg
                85                  90                  95      
Ala Ser Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 284
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 284
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Tyr Arg
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 285
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 285
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Met Pro Tyr Arg
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 286
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 286
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Gln Pro Tyr Arg
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 287
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 287
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Leu Pro Tyr Arg
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 288
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 288
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Glu Pro Tyr Arg
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 289
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 289
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Tyr Asp
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 290
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 290
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Lys Pro Tyr Ser
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 291
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 291
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Gln Pro Tyr Val
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 292
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 292
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Glu Pro Tyr Lys
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 293
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 293
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Leu Pro Tyr Gln
                85                  90                  95      
Ala Ser Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 294
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 294
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Pro His Thr
                85                  90                  95      
Gly Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val
            100                 105                 110         
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys
        115                 120                 125             
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg
    130                 135                 140                 
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn
145                 150                 155                 160 
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser
                165                 170                 175     
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys
            180                 185                 190         
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
        195                 200                 205             
Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215     


<210> 295
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 295
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Ala His Asp
                85                  90                  95      
Gly Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val
            100                 105                 110         
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys
        115                 120                 125             
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg
    130                 135                 140                 
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn
145                 150                 155                 160 
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser
                165                 170                 175     
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys
            180                 185                 190         
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
        195                 200                 205             
Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215     


<210> 296
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 296
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Ala His Arg
                85                  90                  95      
Gly Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val
            100                 105                 110         
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys
        115                 120                 125             
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg
    130                 135                 140                 
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn
145                 150                 155                 160 
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser
                165                 170                 175     
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys
            180                 185                 190         
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
        195                 200                 205             
Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215     


<210> 297
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 297
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Arg Ala His Thr
                85                  90                  95      
Gly Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val
            100                 105                 110         
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys
        115                 120                 125             
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg
    130                 135                 140                 
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn
145                 150                 155                 160 
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser
                165                 170                 175     
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys
            180                 185                 190         
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
        195                 200                 205             
Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215     


<210> 298
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 298
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Ala His Thr
                85                  90                  95      
Gly Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val
            100                 105                 110         
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys
        115                 120                 125             
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg
    130                 135                 140                 
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn
145                 150                 155                 160 
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser
                165                 170                 175     
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys
            180                 185                 190         
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
        195                 200                 205             
Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215     


<210> 299
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 299
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Asp His His
                85                  90                  95      
Gly Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val
            100                 105                 110         
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys
        115                 120                 125             
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg
    130                 135                 140                 
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn
145                 150                 155                 160 
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser
                165                 170                 175     
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys
            180                 185                 190         
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
        195                 200                 205             
Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215     


<210> 300
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 300
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Asp His Lys
                85                  90                  95      
Gly Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val
            100                 105                 110         
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys
        115                 120                 125             
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg
    130                 135                 140                 
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn
145                 150                 155                 160 
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser
                165                 170                 175     
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys
            180                 185                 190         
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
        195                 200                 205             
Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215     


<210> 301
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 301
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Asp His Arg
                85                  90                  95      
Gly Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val
            100                 105                 110         
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys
        115                 120                 125             
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg
    130                 135                 140                 
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn
145                 150                 155                 160 
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser
                165                 170                 175     
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys
            180                 185                 190         
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
        195                 200                 205             
Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215     


<210> 302
<211> 216
<212> PRT
<213> Artificial Sequence

<220> 
<223> anti-C. albicans 2G12 Fab light chain variant

<400> 302
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Tyr Thr Asp His Tyr
                85                  90                  95      
Gly Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val
            100                 105                 110         
Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys
        115                 120                 125             
Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg
    130                 135                 140                 
Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn
145                 150                 155                 160 
Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser
                165                 170                 175     
Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys
            180                 185                 190         
Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
        195                 200                 205             
Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215     


<210> 303
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 CDRH3

<400> 303
Lys Gly Ser Asp Arg Leu Ser Asp Asn Asp Pro Phe Asp Ala
 1               5                  10                  


<210> 304
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 3ALA CDRH3

<400> 304
Lys Gly Ser Asp Arg Ala Ala Asp Ala Asp Pro Phe Asp Ala
 1               5                  10                  


<210> 305
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 3ALA CDRL3 VL domain

<400> 305
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Ala Ala Gly Ala Ala
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys
            100                 105             


<210> 306
<211> 228
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 3ALA CDRH3 Fab Heavy Chain

<400> 306
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
 1               5                  10                  15      
Ser Leu Ile Leu Ser Cys Gly Val Ser Asn Phe Arg Ile Ser Ala His
            20                  25                  30          
Thr Met Asn Trp Val Arg Arg Val Pro Gly Gly Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Leu Glu Asp Phe Val Tyr
65                  70                  75                  80  
Leu Gln Met His Lys Met Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Gly Ser Asp Arg Ala Ala Asp Ala Asp Pro Phe Asp Ala
            100                 105                 110         
Trp Gly Pro Gly Thr Val Val Thr Val Ser Pro Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
    210                 215                 220                 
Ser Cys Leu Arg
225             


<210> 307
<211> 215
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 3ALA CDRL3 Fab Light Chain

<400> 307
Ala Gly Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val
 1               5                  10                  15      
Gly Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr
            20                  25                  30          
Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln
65                  70                  75                  80  
Phe Asp Asp Phe Ala Thr Tyr His Cys Gln His Ala Ala Gly Ala Ala
                85                  90                  95      
Ala Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala
            100                 105                 110         
Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser
        115                 120                 125             
Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu
    130                 135                 140                 
Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser
145                 150                 155                 160 
Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                165                 170                 175     
Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
            180                 185                 190         
Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys
        195                 200                 205             
Ser Phe Asn Arg Gly Glu Cys
    210                 215 


<210> 308
<211> 454
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 IgG Heavy Chain

<400> 308
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
 1               5                  10                  15      
Ser Leu Ile Leu Ser Cys Gly Val Ser Asn Phe Arg Ile Ser Ala His
            20                  25                  30          
Thr Met Asn Trp Val Arg Arg Val Pro Gly Gly Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Leu Glu Asp Phe Val Tyr
65                  70                  75                  80  
Leu Gln Met His Lys Met Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Gly Ser Asp Arg Leu Ser Asp Asn Asp Pro Phe Asp Ala
            100                 105                 110         
Trp Gly Pro Gly Thr Val Val Thr Val Ser Pro Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
    210                 215                 220                 
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Pro Ala Pro Glu
225                 230                 235                 240 
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
                245                 250                 255     
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
            260                 265                 270         
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
        275                 280                 285             
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
    290                 295                 300                 
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
305                 310                 315                 320 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
                325                 330                 335     
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
            340                 345                 350         
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn
        355                 360                 365             
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
    370                 375                 380                 
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
385                 390                 395                 400 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
                405                 410                 415     
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
            420                 425                 430         
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
        435                 440                 445             
Ser Leu Ser Pro Gly Lys
    450                 


<210> 309
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 CDRH1

<400> 309
Ala His Thr Met Asn
 1               5  


<210> 310
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 CDRH2

<400> 310
Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val Lys
 1               5                  10                  15      
Gly
    


<210> 311
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 CDRL1

<400> 311
Arg Ala Ser Gln Ser Ile Glu Thr Trp Leu Ala
 1               5                  10      


<210> 312
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 CDRL2

<400> 312
Lys Ala Ser Thr Leu Lys Thr
 1               5          


<210> 313
<211> 454
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 mutant V5L, H230S

<400> 313
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
 1               5                  10                  15      
Ser Leu Ile Leu Ser Cys Gly Val Ser Asn Phe Arg Ile Ser Ala His
            20                  25                  30          
Thr Met Asn Trp Val Arg Arg Val Pro Gly Gly Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Leu Glu Asp Phe Val Tyr
65                  70                  75                  80  
Leu Gln Met His Lys Met Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Gly Ser Asp Arg Leu Ser Asp Asn Asp Pro Phe Asp Ala
            100                 105                 110         
Trp Gly Pro Gly Thr Val Val Thr Val Ser Pro Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
    210                 215                 220                 
Ser Cys Asp Lys Thr Ser Thr Cys Pro Pro Cys Pro Pro Ala Pro Glu
225                 230                 235                 240 
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp
                245                 250                 255     
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp
            260                 265                 270         
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly
        275                 280                 285             
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn
    290                 295                 300                 
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp
305                 310                 315                 320 
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro
                325                 330                 335     
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
            340                 345                 350         
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn
        355                 360                 365             
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile
    370                 375                 380                 
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr
385                 390                 395                 400 
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
                405                 410                 415     
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
            420                 425                 430         
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu
        435                 440                 445             
Ser Leu Ser Pro Gly Lys
    450                 


<210> 314
<211> 453
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 mutant D1 V5L (H230 deletion)

<400> 314
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
 1               5                  10                  15      
Ser Leu Ile Leu Ser Cys Gly Val Ser Asn Phe Arg Ile Ser Ala His
            20                  25                  30          
Thr Met Asn Trp Val Arg Arg Val Pro Gly Gly Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Leu Glu Asp Phe Val Tyr
65                  70                  75                  80  
Leu Gln Met His Lys Met Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Gly Ser Asp Arg Leu Ser Asp Asn Asp Pro Phe Asp Ala
            100                 105                 110         
Trp Gly Pro Gly Thr Val Val Thr Val Ser Pro Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
    210                 215                 220                 
Ser Cys Asp Lys Thr Thr Cys Pro Pro Cys Pro Pro Ala Pro Glu Leu
225                 230                 235                 240 
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
                245                 250                 255     
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
            260                 265                 270         
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
        275                 280                 285             
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
    290                 295                 300                 
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
305                 310                 315                 320 
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                325                 330                 335     
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
            340                 345                 350         
Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln
        355                 360                 365             
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
    370                 375                 380                 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
385                 390                 395                 400 
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
                405                 410                 415     
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
            420                 425                 430         
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
        435                 440                 445             
Leu Ser Pro Gly Lys
    450             


<210> 315
<211> 452
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 mutant D2 V5L (T229-H230 deletion)

<400> 315
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
 1               5                  10                  15      
Ser Leu Ile Leu Ser Cys Gly Val Ser Asn Phe Arg Ile Ser Ala His
            20                  25                  30          
Thr Met Asn Trp Val Arg Arg Val Pro Gly Gly Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Leu Glu Asp Phe Val Tyr
65                  70                  75                  80  
Leu Gln Met His Lys Met Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Gly Ser Asp Arg Leu Ser Asp Asn Asp Pro Phe Asp Ala
            100                 105                 110         
Trp Gly Pro Gly Thr Val Val Thr Val Ser Pro Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
    210                 215                 220                 
Ser Cys Asp Lys Thr Cys Pro Pro Cys Pro Pro Ala Pro Glu Leu Leu
225                 230                 235                 240 
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
                245                 250                 255     
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
            260                 265                 270         
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
        275                 280                 285             
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
    290                 295                 300                 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
305                 310                 315                 320 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
                325                 330                 335     
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
            340                 345                 350         
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val
        355                 360                 365             
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
    370                 375                 380                 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
385                 390                 395                 400 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
                405                 410                 415     
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
            420                 425                 430         
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
        435                 440                 445             
Ser Pro Gly Lys
    450         


<210> 316
<211> 451
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 mutant D3 V5L (K228-H230 deletion)

<400> 316
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
 1               5                  10                  15      
Ser Leu Ile Leu Ser Cys Gly Val Ser Asn Phe Arg Ile Ser Ala His
            20                  25                  30          
Thr Met Asn Trp Val Arg Arg Val Pro Gly Gly Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Leu Glu Asp Phe Val Tyr
65                  70                  75                  80  
Leu Gln Met His Lys Met Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Gly Ser Asp Arg Leu Ser Asp Asn Asp Pro Phe Asp Ala
            100                 105                 110         
Trp Gly Pro Gly Thr Val Val Thr Val Ser Pro Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
    210                 215                 220                 
Ser Cys Asp Thr Cys Pro Pro Cys Pro Pro Ala Pro Glu Leu Leu Gly
225                 230                 235                 240 
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
                245                 250                 255     
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His
            260                 265                 270         
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val
        275                 280                 285             
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
    290                 295                 300                 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
305                 310                 315                 320 
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile
                325                 330                 335     
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
            340                 345                 350         
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser
        355                 360                 365             
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
    370                 375                 380                 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
385                 390                 395                 400 
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val
                405                 410                 415     
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met
            420                 425                 430         
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
        435                 440                 445             
Pro Gly Lys
    450     


<210> 317
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 mutant D4 V5L (D227-H230 deletion)

<400> 317
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
 1               5                  10                  15      
Ser Leu Ile Leu Ser Cys Gly Val Ser Asn Phe Arg Ile Ser Ala His
            20                  25                  30          
Thr Met Asn Trp Val Arg Arg Val Pro Gly Gly Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Leu Glu Asp Phe Val Tyr
65                  70                  75                  80  
Leu Gln Met His Lys Met Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Gly Ser Asp Arg Leu Ser Asp Asn Asp Pro Phe Asp Ala
            100                 105                 110         
Trp Gly Pro Gly Thr Val Val Thr Val Ser Pro Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
    210                 215                 220                 
Ser Cys Thr Cys Pro Pro Cys Pro Pro Ala Pro Glu Leu Leu Gly Gly
225                 230                 235                 240 
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
                245                 250                 255     
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu
            260                 265                 270         
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
        275                 280                 285             
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
    290                 295                 300                 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
305                 310                 315                 320 
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu
                325                 330                 335     
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
            340                 345                 350         
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu
        355                 360                 365             
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
    370                 375                 380                 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
385                 390                 395                 400 
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
                405                 410                 415     
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His
            420                 425                 430         
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
        435                 440                 445             
Gly Lys
    450 


<210> 318
<211> 448
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 mutant D6 V5L (D227-C232 deletion)

<400> 318
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
 1               5                  10                  15      
Ser Leu Ile Leu Ser Cys Gly Val Ser Asn Phe Arg Ile Ser Ala His
            20                  25                  30          
Thr Met Asn Trp Val Arg Arg Val Pro Gly Gly Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Leu Glu Asp Phe Val Tyr
65                  70                  75                  80  
Leu Gln Met His Lys Met Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Gly Ser Asp Arg Leu Ser Asp Asn Asp Pro Phe Asp Ala
            100                 105                 110         
Trp Gly Pro Gly Thr Val Val Thr Val Ser Pro Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
    210                 215                 220                 
Ser Cys Pro Pro Cys Pro Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
225                 230                 235                 240 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                245                 250                 255     
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
            260                 265                 270         
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
        275                 280                 285             
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
    290                 295                 300                 
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
305                 310                 315                 320 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
                325                 330                 335     
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
            340                 345                 350         
Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys
        355                 360                 365             
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
    370                 375                 380                 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
385                 390                 395                 400 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
                405                 410                 415     
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
            420                 425                 430         
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445             


<210> 319
<211> 448
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 mutant D6GG V5L (D227-C232 deletion)

<400> 319
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
 1               5                  10                  15      
Ser Leu Ile Leu Ser Cys Gly Val Ser Asn Phe Arg Ile Ser Ala His
            20                  25                  30          
Thr Met Asn Trp Val Arg Arg Val Pro Gly Gly Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Leu Glu Asp Phe Val Tyr
65                  70                  75                  80  
Leu Gln Met His Lys Met Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Gly Ser Asp Arg Leu Ser Asp Asn Asp Pro Phe Asp Ala
            100                 105                 110         
Trp Gly Pro Gly Thr Val Val Thr Val Ser Pro Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
    210                 215                 220                 
Ser Cys Gly Gly Cys Pro Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
225                 230                 235                 240 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                245                 250                 255     
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
            260                 265                 270         
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
        275                 280                 285             
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
    290                 295                 300                 
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
305                 310                 315                 320 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
                325                 330                 335     
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
            340                 345                 350         
Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys
        355                 360                 365             
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
    370                 375                 380                 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
385                 390                 395                 400 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
                405                 410                 415     
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
            420                 425                 430         
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445             


<210> 320
<211> 452
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 mutant D2 (T229-H230 deletion)

<400> 320
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
 1               5                  10                  15      
Ser Leu Ile Leu Ser Cys Gly Val Ser Asn Phe Arg Ile Ser Ala His
            20                  25                  30          
Thr Met Asn Trp Val Arg Arg Val Pro Gly Gly Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Leu Glu Asp Phe Val Tyr
65                  70                  75                  80  
Leu Gln Met His Lys Met Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Gly Ser Asp Arg Leu Ser Asp Asn Asp Pro Phe Asp Ala
            100                 105                 110         
Trp Gly Pro Gly Thr Val Val Thr Val Ser Pro Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
    210                 215                 220                 
Ser Cys Asp Lys Thr Cys Pro Pro Cys Pro Pro Ala Pro Glu Leu Leu
225                 230                 235                 240 
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
                245                 250                 255     
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
            260                 265                 270         
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
        275                 280                 285             
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
    290                 295                 300                 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
305                 310                 315                 320 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
                325                 330                 335     
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
            340                 345                 350         
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val
        355                 360                 365             
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
    370                 375                 380                 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
385                 390                 395                 400 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
                405                 410                 415     
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
            420                 425                 430         
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
        435                 440                 445             
Ser Pro Gly Lys
    450         


<210> 321
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 3ALA CDRL3 VL domain

<400> 321
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Ala Ala Gly Ala Ala Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys
            100                 105         


<210> 322
<211> 214
<212> PRT
<213> Artificial Sequence

<220> 
<223> 2G12 3ALA CDRL3 Fab Light Chain

<400> 322
Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Ile Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Thr Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Thr Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Gly Leu Gln Phe
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr His Cys Gln His Ala Ala Gly Ala Ala Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn Arg Gly Glu Cys
    210                 


<210> 323
<211> 4765
<212> DNA
<213> Artificial Sequence

<220> 
<223> 3-ALA LC 2G12 pCAL G13

<400> 323
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt 60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa 120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt 180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt 240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt 300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg 360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga 420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa 480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga 540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa 600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca 660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta 720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac 780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc 840
gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag 900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga 960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt 1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata 1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag 1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa 1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt 1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc 1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa 1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa 1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc 1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa 1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa 1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg 1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc 1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg 1800
ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg 1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg 1920
aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat 1980
gcagctggca cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaatg 2040
tgagttagct cactcattag gcaccccagg ctttacactt tatgcttccg gctcgtatgt 2100
tgtgtggaat tgtgagcgga taacaattga attaaggagg atataattat gaaatacctg 2160
ctgccgaccg cagccgctgg tctgctgctg ctcgcggccc agccggccat ggccgccggt 2220
gttgttatga cccagtctcc gtctaccctg tctgcttctg ttggtgacac catcaccatc 2280
acctgccgtg cttctcagtc tatcgaaacc tggctggctt ggtaccagca gaaaccgggt 2340
aaagctccga aactgctgat ctacaaggct tctaccctga aaaccggtgt tccgtctcgt 2400
ttctctggtt ctggttctgg taccgagttc accctgacca tctctggtct gcagttcgac 2460
gacttcgcta cctaccactg ccagcacgcg gctggtgcgg cggctacctt cggtcagggt 2520
acccgtgttg aaatcaaacg taccgttgct gctccgtctg ttttcatctt cccgccgtct 2580
gacgaacagc tgaaatctgg taccgcttct gttgtttgcc tgctgaacaa cttctacccg 2640
cgtgaagcta aagttcagtg gaaagttgac aacgctctgc agtctggtaa ctctcaggaa 2700
tctgttaccg aacaggactc taaagactct acctactctc tgtcttctac cctgaccctg 2760
tctaaagctg actacgaaaa gcacaaagtt tacgcttgcg aagttaccca ccagggtctg 2820
tcttctccgg ttaccaaatc tttcaaccgt ggtgaatgct aattaattaa taaggaggat 2880
ataattatga aaaagacagc tatcgcgatt gcagtggcac tggctggttt cgctaccgta 2940
gcccaggcgg ccgcagaagt tcagctggtt gaatctggtg gtggtctggt taaagctggt 3000
ggttctctga tcctgtcttg cggtgtttct aacttccgta tctctgctca caccatgaac 3060
tgggttcgtc gtgttccggg tggtggtctg gaatgggttg cttctatctc tacctcttct 3120
acctaccgtg actacgctga cgctgttaaa ggtcgtttca ccgtttctcg tgacgacctg 3180
gaagacttcg tttacctgca gatgcataaa atgcgtgttg aagacaccgc tatctactac 3240
tgcgctcgta aaggttctga ccgtctgtct gacaacgacc cgttcgacgc ttggggtccg 3300
ggtaccgttg ttaccgtttc tccggcgtcg accaaaggtc cgtctgtttt cccgctggct 3360
ccgtcttcta aatctacctc tggtggtacc gctgctctgg gttgcctggt taaagactac 3420
ttcccggaac cggttaccgt ttcttggaac tctggtgctc tgacctctgg tgttcacacc 3480
ttcccggctg ttctgcagtc ttctggtctg tactctctgt cttctgttgt taccgttccg 3540
tcttcttctc tgggtaccca gacctacatc tgcaacgtta accacaaacc gtctaacacc 3600
aaagttgaca agaaagttga accgaaatct tgcctgcgat cgcggccagg ccggccgcac 3660
catcaccatc accatggcgc atacccgtac gacgttccgg actacgcttc tactagttag 3720
gagggtggtg gctctgaggg tggcggttct gagggtggcg gctctgaggg aggcggttcc 3780
ggtggtggct ctggttccgg tgattttgat tatgaaaaga tggcaaacgc taataagggg 3840
gctatgaccg aaaatgccga tgaaaacgcg ctacagtctg acgctaaagg caaacttgat 3900
tctgtcgcta ctgattacgg tgctgctatc gatggtttca ttggtgacgt ttccggcctt 3960
gctaatggta atggtgctac tggtgatttt gctggctcta attcccaaat ggctcaagtc 4020
ggtgacggtg ataattcacc tttaatgaat aatttccgtc aatatttacc ttccctccct 4080
caatcggttg aatgtcgccc ttttgtcttt ggcgctggta aaccatatga attttctatt 4140
gattgtgaca aaataaactt attccgtggt gtctttgcgt ttcttttata tgttgccacc 4200
tttatgtatg tattttctac gtttgctaac atactgcgta ataaggagtc ttaagctagc 4260
taacgatcgc ccttcccaac agttgcgcag cctgaatggc gaatgggacg cgccctgtag 4320
cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag 4380
cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt 4440
tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca 4500
cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata 4560
gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca 4620
aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc 4680
gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattttaa 4740
caaaatatta acgcttacaa tttag                                       4765

<210> 324
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12LCF1

<400> 324
gccgctgtgc catcgctcag taaccaattg aattaaggag ga                    42

<210> 325
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12LCR1

<400> 325
ggcggcgctc ttctagcgaa gtcgtcgaac tgcag                            35

<210> 326
<211> 54
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12ALACF2

<400> 326
gctacctacc actgccagca cgccgcgggt gcggccgcga ccttcggtca gggt       54

<210> 327
<211> 54
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12ALACR2

<400> 327
ggtaccctga ccgaaggtcg cggccgcacc cgcggcgtgc tggcagtggt aggt       54

<210> 328
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12LCF3

<400> 328
ggcggcgctc ttctacccgt gttgaaatca aacgt                            35

<210> 329
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12IgGLC-F

<400> 329
ggtccctggc tcgagtgagg ttgttatgac ccagtctccg tc                    42

<210> 330
<211> 44
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12IgGLC-R

<400> 330
cctggtaccg aattcttagc attcaccacg gttgaaagat ttgg                  44

<210> 331
<211> 63
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12HindIIILC-F1

<400> 331
gtaagcaagc ttatggacat gagagtgcct gcacagctgc tgggactgct gctgctgtgg 60
ctg                                                               63

<210> 332
<211> 62
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12HindIIILC-F2

<400> 332
ggactgctgc tgctgtggct gccaggcgcc aagtgcgacg ttgttatgac ccagtctccg 60
tc                                                                62

<210> 333
<211> 46
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12EcoRILC-R

<400> 333
cgctacgaat tctcagcatt caccacggtt gaaagatttg gtaacc                46

<210> 334
<211> 453
<212> PRT
<213> Artificial Sequence

<220> 
<223> pCALM 2G12 IgG Heavy Chain

<400> 334
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
 1               5                  10                  15      
Ser Leu Ile Leu Ser Cys Gly Val Ser Asn Phe Arg Ile Ser Ala His
            20                  25                  30          
Thr Met Asn Trp Val Arg Arg Val Pro Gly Gly Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Leu Glu Asp Phe Val Tyr
65                  70                  75                  80  
Leu Gln Met His Lys Met Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Gly Ser Asp Arg Leu Ser Asp Asn Asp Pro Phe Asp Ala
            100                 105                 110         
Trp Gly Pro Gly Thr Val Val Thr Val Ser Pro Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
    210                 215                 220                 
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu
225                 230                 235                 240 
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
                245                 250                 255     
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
            260                 265                 270         
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
        275                 280                 285             
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
    290                 295                 300                 
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
305                 310                 315                 320 
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                325                 330                 335     
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
            340                 345                 350         
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
        355                 360                 365             
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
    370                 375                 380                 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
385                 390                 395                 400 
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
                405                 410                 415     
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
            420                 425                 430         
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
        435                 440                 445             
Leu Ser Pro Gly Lys
    450             


<210> 335
<211> 452
<212> PRT
<213> Artificial Sequence

<220> 
<223> pDR12 2G12 IgG Heavy Chain

<400> 335
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
 1               5                  10                  15      
Ser Leu Ile Leu Ser Cys Gly Val Ser Asn Phe Arg Ile Ser Ala His
            20                  25                  30          
Thr Met Asn Trp Val Arg Arg Val Pro Gly Gly Gly Leu Glu Trp Val
        35                  40                  45              
Ala Ser Ile Ser Thr Ser Ser Thr Tyr Arg Asp Tyr Ala Asp Ala Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asp Leu Glu Asp Phe Val Tyr
65                  70                  75                  80  
Leu Gln Met His Lys Met Arg Val Glu Asp Thr Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Lys Gly Ser Asp Arg Leu Ser Asp Asn Asp Pro Phe Asp Ala
            100                 105                 110         
Trp Gly Pro Gly Thr Val Val Thr Val Ser Pro Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
    210                 215                 220                 
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Ala Pro Glu Leu Leu
225                 230                 235                 240 
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
                245                 250                 255     
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
            260                 265                 270         
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
        275                 280                 285             
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
    290                 295                 300                 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
305                 310                 315                 320 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
                325                 330                 335     
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
            340                 345                 350         
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val
        355                 360                 365             
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
    370                 375                 380                 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
385                 390                 395                 400 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
                405                 410                 415     
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
            420                 425                 430         
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
        435                 440                 445             
Ser Pro Gly Lys
    450         


<210> 336
<211> 6455
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 pCALM 8His

<400> 336
atgcattagt tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga 60
gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg 120
cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg 180
acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca 240
tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc 300
ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat tagtcatcgc 360
tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc 420
acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa 480
tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag 540
gcgtgtacgg tgggaggtct atataagcag agctggttta gtgaaccgtc agatccgcta 600
gcgattacgc caagctcgaa attaaccctc actaaaggga acaaaagctg gagctccacc 660
gcggtggcgg ccgcccacca tggactggac ctggcggatc ctgttcctgg tggccgcggc 720
caccggagcc cacagcgaag ttcagctggt tgaatctggt ggtggtctgg ttaaagctgg 780
tggttctctg atcctgtctt gcggtgtttc taacttccgt atctctgctc acaccatgaa 840
ctgggttcgt cgtgttccgg gtggtggtct ggaatgggtt gcttctatct ctacctcttc 900
tacctaccgt gactacgctg acgctgttaa aggtcgtttc accgtttctc gtgacgacct 960
ggaagacttc gtttacctgc agatgcataa aatgcgtgtt gaagacaccg ctatctacta 1020
ctgcgctcgt aaaggttctg accgtctgtc tgacaacgac ccgttcgacg cttggggtcc 1080
gggtaccgtt gttaccgttt ctccggctag caccaagggc cccagcgtgt tccccctggc 1140
ccccagcagc aagagcacca gcggcggcac cgccgccctg ggctgcctgg tgaaggacta 1200
cttccccgag cccgtgaccg tgagctggaa cagcggcgcc ctgaccagcg gcgtgcacac 1260
cttccccgcc gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgaccgtgcc 1320
cagcagcagc ctgggcaccc agacctacat ctgcaacgtg aaccacaagc ccagcaacac 1380
caaggtggac aagaaggtgg agcccaagag ctgcgacaaa actcacacat gcccaccgtg 1440
cccagcacct gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga 1500
caccctcatg atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga 1560
agaccctgag gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac 1620
aaagccgcgg gaggagcagt acaacagcac gtaccgggtg gtcagcgtcc tcaccgtcct 1680
gcaccaggac tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc 1740
agcccccatc gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta 1800
caccctgccc ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt 1860
caaaggcttc tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa 1920
caactacaag accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa 1980
gctcaccgtg gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca 2040
tgaggctctg cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaaggcgg 2100
gtctcatcac caccatcacc atcaccatgg cactagtcgg gccaagcggg cacccgtgaa 2160
gcagaccctg aacttcgacc tgctgaagct ggccggcgac gtggagagca accccggccc 2220
catgaggctc cctgctcagc tcctggggct gctaatgctc tgggtccctg gctcgagtga 2280
ggttgttatg acccagtctc cgtctaccct gtctgcttct gttggtgaca ccatcaccat 2340
cacctgccgt gcttctcagt ctatcgaaac ctggctggct tggtaccagc agaaaccggg 2400
taaagctccg aaactgctga tctacaaggc ttctaccctg aaaaccggtg ttccgtctcg 2460
tttctctggt tctggttctg gtaccgagtt caccctgacc atctctggtc tgcagttcga 2520
cgacttcgct acctaccact gccagcacta cgctggttac tctgctacct tcggtcaggg 2580
tacccgtgtt gaaatcaaac gtaccgttgc tgctccgtct gttttcatct tcccgccgtc 2640
tgacgaacag ctgaaatctg gtaccgcttc tgttgtttgc ctgctgaaca acttctaccc 2700
gcgtgaagct aaagttcagt ggaaagttga caacgctctg cagtctggta actctcagga 2760
atctgttacc gaacaggact ctaaagactc tacctactct ctgtcttcta ccctgaccct 2820
gtctaaagct gactacgaaa agcacaaagt ttacgcttgc gaagttaccc accagggtct 2880
gtcttctccg gttaccaaat ctttcaaccg tggtgaatgc taagaattcg gtaccaggta 2940
agtgtaccca attcgcccta tagtgagtcg tattacaatt cactcgatcg cccttcccaa 3000
cagttgcgca gcctgaatgg cgaatggaga tccaattttt aagtgtataa tgtgttaaac 3060
tactgattct aattgtttgt gtattttaga ttcacagtcc caaggctcat ttcaggcccc 3120
tcagtcctca cagtctgttc atgatcataa tcagccatac cacatttgta gaggttttac 3180
ttgctttaaa aaacctccca cacctccccc tgaacctgaa acataaaatg aatgcaattg 3240
ttgttgttaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa 3300
atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca 3360
atgtatctta acgcgtaaat tgtaagcgtt aatattttgt taaaattcgc gttaaatttt 3420
tgttaaatca gctcattttt taaccaatag gccgaaatcg gcaaaatccc ttataaatca 3480
aaagaataga ccgagatagg gttgagtgtt gttccagttt ggaacaagag tccactatta 3540
aagaacgtgg actccaacgt caaagggcga aaaaccgtct atcagggcga tggcccacta 3600
cgtgaaccat caccctaatc aagttttttg gggtcgaggt gccgtaaagc actaaatcgg 3660
aaccctaaag ggagcccccg atttagagct tgacggggaa agccggcgaa cgtggcgaga 3720
aaggaaggga agaaagcgaa aggagcgggc gctagggcgc tggcaagtgt agcggtcacg 3780
ctgcgcgtaa ccaccacacc cgccgcgctt aatgcgccgc tacagggcgc gtcaggtggc 3840
acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat acattcaaat 3900
atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg aaaaaggaag 3960
aatcctgagg cggaaagaac cagctgtgga atgtgtgtca gttagggtgt ggaaagtccc 4020
caggctcccc agcaggcaga agtatgcaaa gcatgcatct caattagtca gcaaccaggt 4080
gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat ctcaattagt 4140
cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg cccagttccg 4200
cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc gaggccgcct 4260
cggcctctga gctattccag aagtagtgag gaggcttttt tggaggccta ggcttttgca 4320
aagatcgatc aagagacagg atgaggatcg tttcgcatga ttgaacaaga tggattgcac 4380
gcaggttctc cggccgcttg ggtggagagg ctattcggct atgactgggc acaacagaca 4440
atcggctgct ctgatgccgc cgtgttccgg ctgtcagcgc aggggcgccc ggttcttttt 4500
gtcaagaccg acctgtccgg tgccctgaat gaactgcaag acgaggcagc gcggctatcg 4560
tggctggcca cgacgggcgt tccttgcgca gctgtgctcg acgttgtcac tgaagcggga 4620
agggactggc tgctattggg cgaagtgccg gggcaggatc tcctgtcatc tcaccttgct 4680
cctgccgaga aagtatccat catggctgat gcaatgcggc ggctgcatac gcttgatccg 4740
gctacctgcc cattcgacca ccaagcgaaa catcgcatcg agcgagcacg tactcggatg 4800
gaagccggtc ttgtcgatca ggatgatctg gacgaagaac atcaggggct cgcgccagcc 4860
gaactgttcg ccaggctcaa ggcgagcatg cccgacggcg aggatctcgt cgtgacccat 4920
ggcgatgcct gcttgccgaa tatcatggtg gaaaatggcc gcttttctgg attcatcgac 4980
tgtggccggc tgggtgtggc ggaccgctat caggacatag cgttggctac ccgtgatatt 5040
gctgaagaac ttggcggcga atgggctgac cgcttcctcg tgctttacgg tatcgccgct 5100
cccgattcgc agcgcatcgc cttctatcgc cttcttgacg agttcttctg agcgggactc 5160
tggggttcga aatgaccgac caagcgacgc ccaacctgcc atcacgagat ttcgattcca 5220
ccgccgcctt ctatgaaagg ttgggcttcg gaatcgtttt ccgggacgcc ggctggatga 5280
tcctccagcg cggggatctc atgctggagt tcttcgccca ccctaggggg aggctaactg 5340
aaacacggaa ggagacaata ccggaaggaa cccgcgctat gacggcaata aaaagacaga 5400
ataaaacgca cggtgttggg tcgtttgttc ataaacgcgg ggttcggtcc cagggctggc 5460
actctgtcga taccccaccg agaccccatt ggggccaata cgcccgcgtt tcttcctttt 5520
ccccacccca ccccccaagt tcgggtgaag gcccagggct cgcagccaac gtcggggcgg 5580
caggccctgc catagcctca ggttactcat atatacttta gattgattta aaacttcatt 5640
tttaatttaa aaggatctag gtgaagatcc tttttgataa tctcatgacc aaaatccctt 5700
aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa ggatcttctt 5760
gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag 5820
cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta actggcttca 5880
gcagagcgca gataccaaat actgtccttc tagtgtagcc gtagttaggc caccacttca 5940
agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca gtggctgctg 6000
ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta ccggataagg 6060
cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag cgaacgacct 6120
acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga 6180
gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc 6240
ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg 6300
agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg 6360
cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgttc tttcctgcgt 6420
tatcccctga ttctgtggat aaccgtatta ccgcc                            6455


<210> 337
<211> 13309
<212> DNA
<213> Artificial Sequence

<220> 
<223> 2G12 pDR12

<400> 337
attgatcata atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc 60
acacctcccc ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat 120
tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt 180
tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg 240
gatctagctt cgtgtcaagg acggtgactg cagtgaataa taaaatgtgt gtttgtccga 300
aatacgcgtt ttgagatttc tgtcgccgac taaattcatg tcgcgcgata gtggtgttta 360
tcgccgatag agatggcgat attggaaaaa tcgatatttg aaaatatggc atattgaaaa 420
tgtcgccgat gtgagtttct gtgtaactga tatcgccatt tttccaaaag tgatttttgg 480
gcatacgcga tatctggcga tagcgcttat atcgtttacg ggggatggcg atagacgact 540
ttggtgactt gggcgattct gtgtgtcgca aatatcgcag tttcgatata ggtgacagac 600
gatatgaggc tatatcgccg atagaggcga catcaagctg gcacatggcc aatgcatatc 660
gatctataca ttgaatcaat attggccatt agccatatta ttcattggtt atatagcata 720
aatcaatatt ggctattggc cattgcatac gttgtatcca tatcataata tgtacattta 780
tattggctca tgtccaacat taccgccatg ttgacattga ttattgacta gttattaata 840
gtaatcaatt acggggtcat tagttcatag cccatatatg gagttccgcg ttacataact 900
tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaataat 960
gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta 1020
tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa gtacgccccc 1080
tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttatg 1140
ggactttcct acttggcagt acatctacgt attagtcatc gctattacca tggtgatgcg 1200
gttttggcag tacatcaatg ggcgtggata gcggtttgac tcacggggat ttccaagtct 1260
ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg actttccaaa 1320
atgtcgtaac aactccgccc cattgacgca aatgggcggt aggcgtgtac ggtgggaggt 1380
ctatataagc acagctcgtt tagtgaaccg tcagatcgcc tggagacgcc atccacgctg 1440
ttttgacctc catagaagac accgggaccg atccagcctc cgcggccggg aacggtgcat 1500
tggaacgcgg attccccgtg ccaagagtga cgtaagtacc gcctatagag tctataggcc 1560
cacccccttg gcttcttatg catgctatac tgtttttggc ttggggtcta tacacccccg 1620
cttcctcatg ttataggtga tggtatagct tagcctatag gtgtgggtta ttgaccatta 1680
ttgaccactc ccctattggt gacgatactt tccattacta atccataaca tggctctttg 1740
ccacaactct ctttattggc tatatgccaa tacactgtcc ttcagagact gacacggact 1800
ctgtattttt acaggatggg gtctcattta ttatttacaa attcacatat acaacaccac 1860
cgtccccagt gcccgcagtt tttattaaac ataacgtggg atctccacgc gaatctcggg 1920
tacgtgttcc ggacatgggc tcttctccgg tagcggcgga gcttctacat ccgagccctg 1980
ctcccatgcc tccagcgact catggtcgct cggcagctcc ttgctcctaa cagtggaggc 2040
cagacttagg cacagcacga tgcccaccac caccagtgtg ccgcacaagg ccgtggcggt 2100
agggtatgtg tctgaaaatc agctcgggga gcgggcttgc accgctgacg catttggaag 2160
acttaaggca gcggcagaag aagatgcagg cagctgagtt gttgtgttct gataagagtc 2220
agaggtaact cccgttgcgg tgctgttaac ggtggagggc agtgtagtct gagcagtact 2280
cgttgctgcc gcgcgcgcca ccagacataa tagctgacag actaacagac tgttcctttc 2340
catgggtctt ttctgcagtc accgtccttg acacgaagct ctagagccgc caccatggaa 2400
ctggggctcc gctgggtttt ccttgttgct attttagaag gtgtccagtg tgaggtgcag 2460
ctggtggagt ctgggggagg cctggtcaag gcgggaggat ccctcatact ctcctgtgga 2520
gtctctaatt ttagaatctc tgcccatacc atgaattggg tccgccgggt tccagggggg 2580
gggctggagt gggtcgcttc cattagtacg agttccactt atagagacta tgcagacgct 2640
gtgaagggcc gattcaccgt ttccagagac gacctcgaag actttgtgta tttgcaaatg 2700
cacaaaatga gagtcgaaga cacggctatt tattactgcg ccagaaaggg atctgacaga 2760
ctaagcgaca acgatccttt tgatgcctgg ggcccaggga cagtggtcac cgtctctccc 2820
gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg 2880
ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg 2940
tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca 3000
ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc 3060
tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttggtgag 3120
aggccagcac agggagggag ggtgtctgct ggaagccagg ctcagcgctc ctgcctggac 3180
gcatcccggc tatgcagccc cagtccaggg cagcaaggca ggccccgtct gcctcttcac 3240
ccggaggcct ctgcccgccc cactcatgct cagggagagg gtcttctggc tttttcccca 3300
ggctctgggc aggcacaggc taggtgcccc taacccaggc cctgcacaca aaggggcagg 3360
tgctgggctc agacctgcca agagccatat ccgggaggac cctgcccctg acctaagccc 3420
accccaaagg ccaaactctc cactccctca gctcggacac cttctctcct cccagattcg 3480
agtaactccc aatcttctct ctgcagagcc caaatcttgt gacaaaactc acacatgccc 3540
accgtgccca ggtaagccag cccaggcctc gccctccagc tcaaggcggg acaggtgccc 3600
tagagtagcc tgcatccagg gacaggcccc agccgggtgc tgacacgtcc acctccatct 3660
cttcctcagc acctgaactc ctggggggac cgtcagtctt cctcttcccc ccaaaaccca 3720
aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg gacgtgagcc 3780
acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg cataatgcca 3840
agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg 3900
tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc aacaaagccc 3960
tcccagcccc catcgagaaa accatctcca aagccaaagg tgggacccgt ggggtgcgag 4020
ggccacatgg acagaggccg gctcggccca ccctctgccc tgagagtgac cgctgtacca 4080
acctctgtcc ctacagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg 4140
gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc 4200
gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct 4260
cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc 4320
aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac 4380
tacacgcaga agagcctctc cctgtctccg ggtaaatgag tgcgacggcc ggcaagcccc 4440
gctccccggg ctctcgcggt cgcacgagga tgcttggcac gtaccccctg tacatacttc 4500
ccgggcgccc agcatggaaa taaagcaccc agcgctgccc tgggcccctg cgagactgtg 4560
atggttcttt ccacgggtca ggccgagtct gaggcctgag tggcatgagg gaggcagagc 4620
gggtcccact gtccccacac tggcccaggc tgtgcaggtg tgcctgggcc ccctagggtg 4680
gggctcagcc aggggctgcc ctcggcaggg tgggggattt gccagcgtgg ccctccctcc 4740
agcagcacct gccctgggct gggccacggg aagccctagg agcccctggg gacagacaca 4800
cagcccctgc ctctgtagga gactgtcctg ttctgtgagc gcccctgtcc tcccgacctc 4860
catgcccact cgggggcatg cctagtccat gtgcgtaggg acaggccctc cctcacccat 4920
ctacccccac ggcactaacc cctggctgcc ctgcccagcc tcgcacccgc atggggacac 4980
aaccgactcc ggggacatgc actctcgggc cctgtggagg gactggtgca gatgcccaca 5040
cacacactca gcccagaccc gttcaacaaa ccccgcactg aggttggccg gccacacggc 5100
caccacacac acacgtgcac gcctcacaca cggagcctca cccgggcgaa ctgcacagca 5160
cccagaccag agcaaggtcc tcgcacacgt gaacactcct cggacacagg cccccacgag 5220
ccccacgcgg cacctcaagg cccacgagcc tctcggcagc ttctccacat gctgacctgc 5280
tcagacaaac ccagccctcc tctcacaagg gtgcccctgc agccgccaca cacacacagg 5340
ggatcacaca ccacgtcacg tccctggccc tggcccactt cccagtgccg cccttccctg 5400
cagacggatc ataatcagcc ataccacatt tgtagaggtt ttacttgctt taaaaaacct 5460
cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg ttaacttgtt 5520
tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc 5580
atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt 5640
ctggatcaga tcctctacgc cggacgcatc gtggccggca tcaccggcgc cacaggtgcg 5700
gttgctggcg cctatatcgc cgacatcacc gatggggaag atcgggctcg ccacttcggg 5760
ctcatgagcg cttgtttcgg cgtgggtatg gtggcaggcc cgtggccggg ggactgttgg 5820
gcgccatctc cttgcatgca ccattccttg cggcggcggt gctcaacggc ctcaacctac 5880
tactgggctg cttcctaatg caggagtcgc ataagggaga gcgtcgacct cgggccgcgt 5940
tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa 6000
gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct 6060
ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc 6120
cttcgggaag cgtggcgctt tctcaatgct cacgctgtag gtatctcagt tcggtgtagg 6180
tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct 6240
tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag 6300
cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga 6360
agtggtggcc taactacggc tacactagaa ggacagtatt tggtatctgc gctctgctga 6420
agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg 6480
gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag 6540
aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag 6600
ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat 6660
gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct 6720
taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac 6780
tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa 6840
tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg 6900
gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt 6960
gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca 7020
ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt 7080
cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg gttagctcct 7140
tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg 7200
cagcactgca tcttactgtc atgccatccg taagatgctt ttctgtgact ggtgagtact 7260
caaccaagtc attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa 7320
cacgggataa taccgcgcca catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt 7380
cttcggggcg aaaactctca aggatcttac cgctgttgag atccagttcg atgtaaccca 7440
ctcgtgcacc caactgatct tcagcatctt ttactttcac cagcgtttct gggtgagcaa 7500
aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa tgttgaatac 7560
tcatactctt cctttttcaa tattattgaa gcatttatca gggttattgt ctcatgagcg 7620
gatacatatt tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc acatttcccc 7680
gaaaagtgcc acctgacgtc taagaaacca ttattatcat gacattaacc tataaaaata 7740
ggcgtatcac gaggccctga tggctctttg cggcacccat cgttcgtaat gttccgtggc 7800
accgaggaca accctcaaga gaaaatgtaa tcacactggc tcaccttcgg gtgggccttt 7860
ctgcgtttat aaggagacac tttatgttta agaaggttgg taaattcctt gcggctttgg 7920
cagccaagct agatccggct gtggaatgtg tgtcagttag ggtgtggaaa gtccccaggc 7980
tccccagcag gcagaagtat gcaaagcatg catctcaatt agtcagcaac caggctcccc 8040
agcaggcaga agtatgcaaa gcatgcatct caattagtca gcaaccatag tcccgcccct 8100
aactccgccc atcccgcccc taactccgcc cagttccgcc cattctccgc cccatggctg 8160
actaattttt tttatttatg cagaggccga ggccgcctcg gcctctgagc tattccagaa 8220
gtagtgagga ggcttttttg gaggcctagg cttttgcaaa aacctagctt ggggccaccg 8280
ctcagagcac cttccaccat ggccacctca gcaagttccc acttgaacaa aaacatcaag 8340
caaatgtact tgtgcctgcc ccagggtgag aaagtccaag ccatgtatat ctgggttgat 8400
ggtactggag aaggactgcg ctgcaaaacc cgcaccctgg actgtgagcc caagtgtgta 8460
gaagagttac ctgagtggaa ttttgatggc tctagtacct ttcagtctga gggctccaac 8520
agtgacatgt atctcagccc tgttgccatg tttcgggacc ccttccgcag agatcccaac 8580
aagctggtgt tctgtgaagt tttcaagtac aaccggaagc ctgcagagac caatttaagg 8640
cactcgtgta aacggataat ggacatggtg agcaaccagc acccctggtt tggaatggaa 8700
caggagtata ctctgatggg aacagatggg cacccttttg gttggccttc caatggcttt 8760
cctgggcccc aaggtccgta ttactgtggt gtgggcgcag acaaagccta tggcagggat 8820
atcgtggagg ctcactaccg cgcctgcttg tatgctgggg tcaagattac aggaacaaat 8880
gctgaggtca tgcctgccca gtgggaactc caaataggac cctgtgaagg aatccgcatg 8940
ggagatcatc tctgggtggc ccgtttcatc ttncatcgag tatgtgaaga ctttggggta 9000
atagcaacct ttgaccccaa gcccattcct gggaactgga atggtgcagg ctgccatacc 9060
aactttagca ccaaggccat gcgggaggag aatggtctga agcacatcga ggaggccatc 9120
gagaaactaa gcaagcggca ccggtaccac attcgagcct acgatcccaa ggggggcctg 9180
gacaatgccc gtggtctgac tgggttccac gaaacgtcca acatcaacga cttttctgct 9240
ggtgtcgcca atcgcagtgc cagcatccgc attccccgga ctgtcggcca ggagaagaaa 9300
ggttactttg aagaccgcgg cccctctgcc aattgtgacc cctttgcagt gacagaagcc 9360
atcgtccgca catgccttct caatgagact ggccacgagc ccttccaata caaaaactaa 9420
ttagactttg agtgatcttg agcctttcct agttcatccc accccgcccc agagagatct 9480
ttgtgaagga accttacttc tgtggtgtga cataattgga caaactacct acagagattt 9540
aaagctctaa ggtaaatata aaatttttaa gtgtataatg tgttaaacta ctgattctaa 9600
ttgtttgtgt attttagatt ccaacctatg gaactgatga atgggagcag tggtggaatg 9660
cctttaatga ggaaaacctg ttttgctcag aagaaatgcc atctagtgat gatgaggcta 9720
ctgctgactc tcaacattct actcctccaa aaaagaagag aaaggtagaa gaccccaagg 9780
actttccttc agaattgcta agttttttga gtcatgctgt gtttagtaat agaactcttg 9840
cttgctttgc tatttacacc acaaaggaaa aagctgcact gctatacaag aaaattatgg 9900
aaaaatattc tgtaaccttt ataagtaggc ataacagtta taatcataac atactgtttt 9960
ttcttactcc acacaggcat agagtgtctg ctattaataa ctatgctcaa aaattgtgta 10020
cctttagctt tttaatttgt aaaggggtta ataaggaata tttgatgtat agtgccttga 10080
ctagagatca taatcagcca taccacattt gtagaggttt tacttgcttt aaaaaacctc 10140
ccacacctcc ccctgaacct gaaacataaa atgaatgcaa ttgttgttgt taacttgttt 10200
attgcagctt ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca 10260
tttttttcac tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc 10320
tggatctagc ttcgtgtcaa ggacggtgac tgcagtgaat aataaaatgt gtgtttgtcc 10380
gaaatacgcg ttttgagatt tctgtcgccg actaaattca tgtcgcgcga tagtggtgtt 10440
tatcgccgat agagatggcg atattggaaa aatcgatatt tgaaaatatg gcatattgaa 10500
aatgtcgccg atgtgagttt ctgtgtaact gatatcgcca tttttccaaa agtgattttt 10560
gggcatacgc gatatctggc gatagcgctt atatcgttta cgggggatgg cgatagacga 10620
ctttggtgac ttgggcgatt ctgtgtgtcg caaatatcgc agtttcgata taggtgacag 10680
acgatatgag gctatatcgc cgatagaggc gacatcaagc tggcacatgg ccaatgcata 10740
tcgatctata cattgaatca atattggcca ttagccatat tattcattgg ttatatagca 10800
taaatcaata ttggctattg gccattgcat acgttgtatc catatcataa tatgtacatt 10860
tatattggct catgtccaac attaccgcca tgttgacatt gattattgac tagttattaa 10920
tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg cgttacataa 10980
cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt gacgtcaata 11040
atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca atgggtggag 11100
tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc aagtacgccc 11160
cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta catgacctta 11220
tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac catggtgatg 11280
cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg atttccaagt 11340
ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg ggactttcca 11400
aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt acggtgggag 11460
gtctatataa gcacagctcg tttagtgaac cgtcagatcg cctggagacg ccatccacgc 11520
tgttttgacc tccatagaag acaccgggac cgatccagcc tccgcggccg ggaacggtgc 11580
attggaacgc ggattccccg tgccaagagt gacgtaagta ccgcctatag agtctatagg 11640
cccaccccct tggcttctta tgcatgctat actgtttttg gcttggggtc tatacacccc 11700
cgcttcctca tgttataggt gatggtatag cttagcctat aggtgtgggt tattgaccat 11760
tattgaccac tcccctattg gtgacgatac tttccattac taatccataa catggctctt 11820
tgccacaact ctctttattg gctatatgcc aatacactgt ccttcagaga ctgacacgga 11880
ctctgtattt ttacaggatg gggtctcatt tattatttac aaattcacat atacaacacc 11940
accgtcccca gtgcccgcag tttttattaa acataacgtg ggatctccac gcgaatctcg 12000
ggtacgtgtt ccggacatgg gctcttctcc ggtagcggcg gagcttctac atccgagccc 12060
tgctcccatg cctccagcga ctcatggtcg ctcggcagct ccttgctcct aacagtggag 12120
gccagactta ggcacagcac gatgcccacc accaccagtg tgccgcacaa ggccgtggcg 12180
gtagggtatg tgtctgaaaa tcagctcggg gagcgggctt gcaccgctga cgcatttgga 12240
agacttaagg cagcggcaga agaagatgca ggcagctgag ttgttgtgtt ctgataagag 12300
tcagaggtaa ctcccgttgc ggtgctgtta acggtggagg gcagtgtagt ctgagcagta 12360
ctcgttgctg ccgcgcgcgc caccagacat aatagctgac agactaacag actgttcctt 12420
tccatgggtc ttttctgcag tcaccgtcct tgacacgaag cttaccatgg acatgagggt 12480
ccccgctcag ctcctggggc tcctgctgct ctggctccca ggtaaggaag gagaacacta 12540
ggaatttact cagcccagtg tgctcagtac tgcctggtta ttcagggaag tcttcctata 12600
atatgatcaa tagtatgaat atttgtgttt ctatttccaa tctcaggtgc caaatgtgat 12660
gttgtgatga ctcagtctcc ttccaccctg tctgcatctg tcggagacac aatcaccatc 12720
acttgccggg ccagtcagag tattgaaacc tggttggcct ggtatcagca gaagccaggg 12780
aaagccccaa aactcctaat ctacaaggcg tctactttaa aaactggagt cccgtcaaga 12840
ttcagcggca gtggatctgg aacagagttc actcttacca tcagtggcct gcagttcgat 12900
gactttgcaa cttatcactg tcagcactat gctggttatt cagccacttt tggccaggga 12960
accagggtgg agatcaaacg tactgtggct gcaccatctg tcttcatctt cccgccatct 13020
gatgagcagt tgaaatctgg gactgcctct gttgtgtgcc tgctgaataa cttctatccc 13080
agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag 13140
agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgttg 13200
agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg 13260
agttcgcccg tcacaaagag cttcaacagg ggagagtgtt aatgaattc             13309


