                               SEQUENCE LISTING

<110> NEKTAR THERAPEUTICS
      
 
<120> MODIFIED THERAPEUTIC PEPTIDES, METHODS OF THEIR PREPARATION AND USE

<130> 0257.PCT

<140>
<141>

<150> 61/192,673
<151> 2008-09-19

<160> 301   

<170> PatentIn version 3.5

<210> 1
<211> 28
<212> PRT
<213> Homo sapiens

<400> 1
Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly 
1               5                   10                  15      


Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr 
            20                  25              


<210> 2
<211> 10
<212> PRT
<213> Homo sapiens

<400> 2
Tyr Gly Gly Phe Leu Arg Lys Tyr Pro Lys 
1               5                   10  


<210> 3
<211> 110
<212> PRT
<213> Homo sapiens

<400> 3
Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly 
            20                  25                  30          


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
        35                  40                  45              


Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly 
    50                  55                  60                  


Gln Val Glu Leu Gly Gly Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu 
65                  70                  75                  80  


Ala Leu Glu Gly Ser Leu Gln Lys Arg Gly Ile Val Glu Gln Cys Cys 
                85                  90                  95      


Thr Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
            100                 105                 110 


<210> 4
<211> 70
<212> PRT
<213> Homo sapiens

<400> 4
Met Ala Leu Trp Met Arg Leu Leu Pro Leu Leu Ala Leu Leu Ala Leu 
1               5                   10                  15      


Trp Gly Pro Asp Pro Ala Ala Ala Phe Val Asn Gln His Leu Cys Gly 
            20                  25                  30          


Ser His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe 
        35                  40                  45              


Phe Tyr Thr Pro Lys Thr Arg Arg Glu Ala Glu Asp Leu Gln Val Gly 
    50                  55                  60                  


Gln Val Glu Leu Gly Gly 
65                  70  


<210> 5
<211> 40
<212> PRT
<213> Homo sapiens

<400> 5
Gly Pro Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu 
1               5                   10                  15      


Gln Lys Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu 
            20                  25                  30          


Tyr Gln Leu Glu Asn Tyr Cys Asn 
        35                  40  


<210> 6
<211> 82
<212> PRT
<213> Homo sapiens

<400> 6
Gly Ser Gly Leu Thr Asn Ile Lys Thr Glu Glu Ile Ser Glu Val Lys 
1               5                   10                  15      


Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln 
            20                  25                  30          


Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile 
        35                  40                  45              


Ile Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Ile Ile 
    50                  55                  60                  


Thr Leu Val Met Leu Lys Lys Gln Tyr Thr Ser Asn His His Gly Val 
65                  70                  75                  80  


Val Glu 
        


<210> 7
<211> 434
<212> PRT
<213> Homo sapiens

<400> 7
Met Glu Ser Glu Ser Glu Ser Gly Ala Ala Ala Asp Thr Pro Pro Leu 
1               5                   10                  15      


Glu Thr Leu Ser Phe His Gly Asp Glu Glu Ile Ile Glu Val Val Glu 
            20                  25                  30          


Leu Asp Pro Gly Pro Pro Asp Pro Asp Asp Leu Ala Gln Glu Met Glu 
        35                  40                  45              


Asp Val Asp Phe Glu Glu Glu Glu Glu Glu Glu Gly Asn Glu Glu Gly 
    50                  55                  60                  


Trp Val Leu Glu Pro Gln Glu Gly Val Val Gly Ser Met Glu Gly Pro 
65                  70                  75                  80  


Asp Asp Ser Glu Val Thr Phe Ala Leu His Ser Ala Ser Val Phe Cys 
                85                  90                  95      


Val Ser Leu Asp Pro Lys Thr Asn Thr Leu Ala Val Thr Gly Gly Glu 
            100                 105                 110         


Asp Asp Lys Ala Phe Val Trp Arg Leu Ser Asp Gly Glu Leu Leu Phe 
        115                 120                 125             


Glu Cys Ala Gly His Lys Asp Ser Val Thr Cys Ala Gly Phe Ser His 
    130                 135                 140                 


Asp Ser Thr Leu Val Ala Thr Gly Asp Met Ser Gly Leu Leu Lys Val 
145                 150                 155                 160 


Trp Gln Val Asp Thr Lys Glu Glu Val Trp Ser Phe Glu Ala Gly Asp 
                165                 170                 175     


Leu Glu Trp Met Glu Trp His Pro Arg Ala Pro Val Leu Leu Ala Gly 
            180                 185                 190         


Thr Ala Asp Gly Asn Thr Trp Met Trp Lys Val Pro Asn Gly Asp Cys 
        195                 200                 205             


Lys Thr Phe Gln Gly Pro Asn Cys Pro Ala Thr Cys Gly Arg Val Leu 
    210                 215                 220                 


Pro Asp Gly Lys Arg Ala Val Val Gly Tyr Glu Asp Gly Thr Ile Arg 
225                 230                 235                 240 


Ile Trp Asp Leu Lys Gln Gly Ser Pro Ile His Val Leu Lys Gly Thr 
                245                 250                 255     


Glu Gly His Gln Gly Pro Leu Thr Cys Val Ala Ala Asn Gln Asp Gly 
            260                 265                 270         


Ser Leu Ile Leu Thr Gly Ser Val Asp Cys Gln Ala Lys Leu Val Ser 
        275                 280                 285             


Ala Thr Thr Gly Lys Val Val Gly Val Phe Arg Pro Glu Thr Val Ala 
    290                 295                 300                 


Ser Gln Pro Ser Leu Gly Glu Gly Glu Glu Ser Glu Ser Asn Ser Val 
305                 310                 315                 320 


Glu Ser Leu Gly Phe Cys Ser Val Met Pro Leu Ala Ala Val Gly Tyr 
                325                 330                 335     


Leu Asp Gly Thr Leu Ala Ile Tyr Asp Leu Ala Thr Gln Thr Leu Arg 
            340                 345                 350         


His Gln Cys Gln His Gln Ser Gly Ile Val Gln Leu Leu Trp Glu Ala 
        355                 360                 365             


Gly Thr Ala Val Val Tyr Thr Cys Ser Leu Asp Gly Ile Val Arg Leu 
    370                 375                 380                 


Trp Asp Ala Arg Thr Gly Arg Leu Leu Thr Asp Tyr Arg Gly His Thr 
385                 390                 395                 400 


Ala Glu Ile Leu Asp Phe Ala Leu Ser Lys Asp Ala Ser Leu Val Val 
                405                 410                 415     


Thr Thr Ser Gly Asp His Lys Ala Lys Val Phe Cys Val Gln Arg Pro 
            420                 425                 430         


Asp Arg 
        


<210> 8
<211> 39
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polypeptide"  

<400> 8
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210> 9
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"


<220>
<221> misc_feature
<222> (1)..(1)
<223> /note="N-term acetylated" 

<220>
<221> misc_feature
<222> (25)..(25)
<223> /note="C-term amidated" 

<400> 9
Ala Thr Gln Arg Leu Ala Asn Glu Leu Val Arg Leu Gln Thr Tyr Pro 
1               5                   10                  15      


Arg Thr Asn Val Gly Ser Asn Thr Tyr 
            20                  25  


<210> 10
<211> 267
<212> PRT
<213> Homo sapiens

<400> 10
Met Pro Arg Ser Cys Cys Ser Arg Ser Gly Ala Leu Leu Leu Ala Leu 
1               5                   10                  15      


Leu Leu Gln Ala Ser Met Glu Val Arg Gly Trp Cys Leu Glu Ser Ser 
            20                  25                  30          


Gln Cys Gln Asp Leu Thr Thr Glu Ser Asn Leu Leu Glu Cys Ile Arg 
        35                  40                  45              


Ala Cys Lys Pro Asp Leu Ser Ala Glu Thr Pro Met Phe Pro Gly Asn 
    50                  55                  60                  


Gly Asp Glu Gln Pro Leu Thr Glu Asn Pro Arg Lys Tyr Val Met Gly 
65                  70                  75                  80  


His Phe Arg Trp Asp Arg Phe Gly Arg Arg Asn Ser Ser Ser Ser Gly 
                85                  90                  95      


Ser Ser Gly Ala Gly Gln Lys Arg Glu Asp Val Ser Ala Gly Glu Asp 
            100                 105                 110         


Cys Gly Pro Leu Pro Glu Gly Gly Pro Glu Pro Arg Ser Asp Gly Ala 
        115                 120                 125             


Lys Pro Gly Pro Arg Glu Gly Lys Arg Ser Tyr Ser Met Glu His Phe 
    130                 135                 140                 


Arg Trp Gly Lys Pro Val Gly Lys Lys Arg Arg Pro Val Lys Val Tyr 
145                 150                 155                 160 


Pro Asn Gly Ala Glu Asp Glu Ser Ala Glu Ala Phe Pro Leu Glu Phe 
                165                 170                 175     


Lys Arg Glu Leu Thr Gly Gln Arg Leu Arg Glu Gly Asp Gly Pro Asp 
            180                 185                 190         


Gly Pro Ala Asp Asp Gly Ala Gly Ala Gln Ala Asp Leu Glu His Ser 
        195                 200                 205             


Leu Leu Val Ala Ala Glu Lys Lys Asp Glu Gly Pro Tyr Arg Met Glu 
    210                 215                 220                 


His Phe Arg Trp Gly Ser Pro Pro Lys Asp Lys Arg Tyr Gly Gly Phe 
225                 230                 235                 240 


Met Thr Ser Glu Lys Ser Gln Thr Pro Leu Val Thr Leu Phe Lys Asn 
                245                 250                 255     


Ala Ile Ile Lys Asn Ala Tyr Lys Lys Gly Glu 
            260                 265         


<210> 11
<211> 35
<212> PRT
<213> Human immunodeficiency virus type 1

<400> 11
Cys Thr Arg Pro Ser Asn Asn Thr Arg Lys Ser Ile Pro Val Gly Pro 
1               5                   10                  15      


Gly Lys Ala Leu Tyr Ala Thr Gly Ala Ile Ile Gly Asn Ile Arg Gln 
            20                  25                  30          


Ala His Cys 
        35  


<210> 12
<211> 508
<212> PRT
<213> Human immunodeficiency virus type 1

<400> 12
Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Lys Leu Asp Lys Trp 
1               5                   10                  15      


Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Thr Tyr Gln Leu Lys 
            20                  25                  30          


His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro 
        35                  40                  45              


Gly Leu Leu Glu Thr Gly Gly Gly Cys Lys Gln Ile Leu Val Gln Leu 
    50                  55                  60                  


Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu Lys Ser Leu Tyr Asn 
65                  70                  75                  80  


Ala Val Ala Thr Leu Tyr Cys Val His Gln Gly Ile Glu Val Arg Asp 
                85                  90                  95      


Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys 
            100                 105                 110         


Lys Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly Asn Ser Ser Gln Val 
        115                 120                 125             


Ser Gln Asn Tyr Pro Ile Val Gln Asn Leu Gln Gly Gln Met Val His 
    130                 135                 140                 


Gln Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Ile Glu 
145                 150                 155                 160 


Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser 
                165                 170                 175     


Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly 
            180                 185                 190         


Gly His Gln Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu 
        195                 200                 205             


Ala Ala Glu Trp Asp Arg Leu His Pro Ala His Ala Gly Pro Asn Ala 
    210                 215                 220                 


Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr 
225                 230                 235                 240 


Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Ser Asn Pro Pro Val 
                245                 250                 255     


Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys 
            260                 265                 270         


Ile Val Arg Met Tyr Ser Pro Val Ser Ile Leu Asp Ile Arg Gln Gly 
        275                 280                 285             


Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu 
    290                 295                 300                 


Arg Ala Glu Gln Ala Ser Gln Asp Val Lys Asn Trp Met Thr Glu Thr 
305                 310                 315                 320 


Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala 
                325                 330                 335     


Leu Gly Pro Ala Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly 
            340                 345                 350         


Val Gly Gly Pro Ser His Lys Ala Arg Ile Leu Ala Glu Ala Met Ser 
        355                 360                 365             


Gln Val Thr Ser Pro Ala Asn Ile Met Met Gln Arg Gly Asn Phe Arg 
    370                 375                 380                 


Asn Gln Arg Lys Thr Ile Lys Cys Phe Asn Cys Gly Lys Glu Gly His 
385                 390                 395                 400 


Leu Ala Arg His Cys Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys 
                405                 410                 415     


Gly Arg Glu Gly His Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn 
            420                 425                 430         


Phe Leu Gly Lys Ile Trp Pro Ser His Lys Gly Arg Pro Gly Asn Phe 
        435                 440                 445             


Leu Gln Ser Arg Pro Glu Pro Thr Ala Pro Pro Glu Glu Ser Phe Arg 
    450                 455                 460                 


Phe Gly Glu Glu Thr Thr Thr Pro Pro Gln Lys Gln Glu Pro Leu Pro 
465                 470                 475                 480 


Ser Gln Lys Gln Glu Thr Ile Asp Lys Asp Leu Tyr Pro Leu Ala Ser 
                485                 490                 495     


Leu Lys Ser Leu Phe Gly Asn Asp Pro Ser Leu Gln 
            500                 505             


<210> 13
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 13
Asn Leu Arg Ile Ala Leu Arg 
1               5           


<210> 14
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 14
Arg Leu Ala Ile Arg Leu Asn 
1               5           


<210> 15
<211> 40
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polypeptide"  

<400> 15
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val 
        35                  40  


<210> 16
<211> 42
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polypeptide"  

<400> 16
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          


<210> 17
<211> 202
<212> PRT
<213> Homo sapiens

<400> 17
Met Lys Val Leu Ala Ala Gly Val Val Pro Leu Leu Leu Val Leu His 
1               5                   10                  15      


Trp Lys His Gly Ala Gly Ser Pro Leu Pro Ile Thr Pro Val Asn Ala 
            20                  25                  30          


Thr Cys Ala Ile Arg His Pro Cys His Asn Asn Leu Met Asn Gln Ile 
        35                  40                  45              


Arg Ser Gln Leu Ala Gln Leu Asn Gly Ser Ala Asn Ala Leu Phe Ile 
    50                  55                  60                  


Leu Tyr Tyr Thr Ala Gln Gly Glu Pro Phe Pro Asn Asn Leu Asp Lys 
65                  70                  75                  80  


Leu Cys Gly Pro Asn Val Thr Asp Phe Pro Pro Phe His Ala Asn Gly 
                85                  90                  95      


Thr Glu Lys Ala Lys Leu Val Glu Leu Tyr Arg Ile Val Val Tyr Leu 
            100                 105                 110         


Gly Thr Ser Leu Gly Asn Ile Thr Arg Asp Gln Lys Ile Leu Asn Pro 
        115                 120                 125             


Ser Ala Leu Ser Leu His Ser Lys Leu Asn Ala Thr Ala Asp Ile Leu 
    130                 135                 140                 


Arg Gly Leu Leu Ser Asn Val Leu Cys Arg Leu Cys Ser Lys Tyr His 
145                 150                 155                 160 


Val Gly His Val Asp Val Thr Tyr Gly Pro Asp Thr Ser Gly Lys Asp 
                165                 170                 175     


Val Phe Gln Lys Lys Lys Leu Gly Cys Gln Leu Leu Gly Lys Tyr Lys 
            180                 185                 190         


Gln Ile Ile Ala Val Leu Ala Gln Ala Phe 
        195                 200         


<210> 18
<211> 382
<212> PRT
<213> Homo sapiens

<400> 18
Met Asp Phe Gly Leu Ala Leu Leu Leu Ala Gly Leu Leu Gly Leu Leu 
1               5                   10                  15      


Leu Gly Gln Ser Leu Gln Val Lys Pro Leu Gln Val Glu Pro Pro Glu 
            20                  25                  30          


Pro Val Val Ala Val Ala Leu Gly Ala Ser Arg Gln Leu Thr Cys Arg 
        35                  40                  45              


Leu Ala Cys Ala Asp Arg Gly Ala Ser Val Gln Trp Arg Gly Leu Asp 
    50                  55                  60                  


Thr Ser Leu Gly Ala Val Gln Ser Asp Thr Gly Arg Ser Val Leu Thr 
65                  70                  75                  80  


Val Arg Asn Ala Ser Leu Ser Ala Ala Gly Thr Arg Val Cys Val Gly 
                85                  90                  95      


Ser Cys Gly Gly Arg Thr Phe Gln His Thr Val Gln Leu Leu Val Tyr 
            100                 105                 110         


Ala Phe Pro Asp Gln Leu Thr Val Ser Pro Ala Ala Leu Val Pro Gly 
        115                 120                 125             


Asp Pro Glu Val Ala Cys Thr Ala His Lys Val Thr Pro Val Asp Pro 
    130                 135                 140                 


Asn Ala Leu Ser Phe Ser Leu Leu Val Gly Gly Gln Glu Leu Glu Gly 
145                 150                 155                 160 


Ala Gln Ala Leu Gly Pro Glu Val Gln Glu Glu Glu Glu Glu Pro Gln 
                165                 170                 175     


Gly Asp Glu Asp Val Leu Phe Arg Val Thr Glu Arg Trp Arg Leu Pro 
            180                 185                 190         


Pro Leu Gly Thr Pro Val Pro Pro Ala Leu Tyr Cys Gln Ala Thr Met 
        195                 200                 205             


Arg Leu Pro Gly Leu Glu Leu Ser His Arg Gln Ala Ile Pro Val Leu 
    210                 215                 220                 


His Ser Pro Thr Ser Pro Glu Pro Pro Asp Thr Thr Ser Pro Glu Ser 
225                 230                 235                 240 


Pro Asp Thr Thr Ser Pro Glu Ser Pro Asp Thr Thr Ser Gln Glu Pro 
                245                 250                 255     


Pro Asp Thr Thr Ser Pro Glu Pro Pro Asp Lys Thr Ser Pro Glu Pro 
            260                 265                 270         


Ala Pro Gln Gln Gly Ser Thr His Thr Pro Arg Ser Pro Gly Ser Thr 
        275                 280                 285             


Arg Thr Arg Arg Pro Glu Ile Ser Gln Ala Gly Pro Thr Gln Gly Glu 
    290                 295                 300                 


Val Ile Pro Thr Gly Ser Ser Lys Pro Ala Gly Asp Gln Leu Pro Ala 
305                 310                 315                 320 


Ala Leu Trp Thr Ser Ser Ala Val Leu Gly Leu Leu Leu Leu Ala Leu 
                325                 330                 335     


Pro Thr Tyr His Leu Trp Lys Arg Cys Arg His Leu Ala Glu Asp Asp 
            340                 345                 350         


Thr His Pro Pro Ala Ser Leu Arg Leu Leu Pro Gln Val Ser Ala Trp 
        355                 360                 365             


Ala Gly Leu Arg Gly Thr Gly Gln Val Gly Ile Ser Pro Ser 
    370                 375                 380         


<210> 19
<211> 74
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polypeptide"  

<400> 19
Asp Thr Thr Val Ser Glu Pro Ala Pro Ser Cys Val Thr Leu Tyr Gln 
1               5                   10                  15      


Ser Trp Arg Tyr Ser Gln Ala Asp Asn Gly Cys Ala Glu Thr Val Thr 
            20                  25                  30          


Val Lys Val Val Tyr Glu Asp Asp Thr Glu Gly Leu Cys Tyr Ala Val 
        35                  40                  45              


Ala Pro Gly Gln Ile Thr Thr Val Gly Asp Gly Tyr Ile Gly Ser His 
    50                  55                  60                  


Gly His Ala Arg Tyr Leu Ala Arg Cys Leu 
65                  70                  


<210> 20
<211> 151
<212> PRT
<213> Homo sapiens

<400> 20
Met Ser Ser Phe Ser Thr Thr Thr Val Ser Phe Leu Leu Leu Leu Ala 
1               5                   10                  15      


Phe Gln Leu Leu Gly Gln Thr Arg Ala Asn Pro Met Tyr Asn Ala Val 
            20                  25                  30          


Ser Asn Ala Asp Leu Met Asp Phe Lys Asn Leu Leu Asp His Leu Glu 
        35                  40                  45              


Glu Lys Met Pro Leu Glu Asp Glu Val Val Pro Pro Gln Val Leu Ser 
    50                  55                  60                  


Asp Pro Asn Glu Glu Ala Gly Ala Ala Leu Ser Pro Leu Pro Glu Val 
65                  70                  75                  80  


Pro Pro Trp Thr Gly Glu Val Ser Pro Ala Gln Arg Asp Gly Gly Ala 
                85                  90                  95      


Leu Gly Arg Gly Pro Trp Asp Ser Ser Asp Arg Ser Ala Leu Leu Lys 
            100                 105                 110         


Ser Lys Leu Arg Ala Leu Leu Thr Ala Pro Arg Ser Leu Arg Arg Ser 
        115                 120                 125             


Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly Ala Gln Ser Gly Leu 
    130                 135                 140                 


Gly Cys Asn Ser Phe Arg Tyr 
145                 150     


<210> 21
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 21
Thr Thr Ser Gln Val Arg Pro Arg 
1               5               


<210> 22
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 22
Val Lys Thr Thr Ser Gln Val Arg Pro Arg 
1               5                   10  


<210> 23
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 23
Ser Gln Val Arg Pro Arg 
1               5       


<210> 24
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 24
Val Arg Pro Arg 
1               


<210> 25
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 25
Thr Thr Ser Gln Val Arg Pro Arg His Ile Thr 
1               5                   10      


<210> 26
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 26
Thr Thr Ser Gln Val 
1               5   


<210> 27
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 27
Thr Ser Gln Val Arg 
1               5   


<210> 28
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 28
Thr Thr Ser Gly Ile His Pro Lys 
1               5               


<210> 29  
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 29  
Glu Gly Pro Trp Leu Glu Glu Glu Glu 
1               5                   


<210> 30  
<211> 84
<212> PRT
<213> Hirudinaria manillensis

<400> 30  
Met Phe Ser Leu Lys Leu Phe Val Val Phe Leu Ala Val Cys Ile Cys 
1               5                   10                  15      


Val Ser Gln Ala Val Ser Tyr Thr Asp Cys Thr Glu Ser Gly Gln Asn 
            20                  25                  30          


Tyr Cys Leu Cys Val Gly Gly Asn Leu Cys Gly Gly Gly Lys His Cys 
        35                  40                  45              


Glu Met Asp Gly Ser Gly Asn Lys Cys Val Asp Gly Glu Gly Thr Pro 
    50                  55                  60                  


Lys Pro Lys Ser Gln Thr Glu Gly Asp Phe Glu Glu Ile Pro Asp Glu 
65                  70                  75                  80  


Asp Ile Leu Asn 
                


<210> 31  
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 31  
Tyr Ala Gly Ala Val Val Asn Asp Leu 
1               5                   


<210> 32  
<211> 100
<212> PRT
<213> Homo sapiens

<400> 32  
Met Lys Leu Leu Ala Ala Thr Val Leu Leu Leu Thr Ile Cys Ser Leu 
1               5                   10                  15      


Glu Gly Ala Leu Val Arg Arg Gln Ala Lys Glu Pro Cys Val Glu Ser 
            20                  25                  30          


Leu Val Ser Gln Tyr Phe Gln Thr Val Thr Asp Tyr Gly Lys Asp Leu 
        35                  40                  45              


Met Glu Lys Val Lys Ser Pro Glu Leu Gln Ala Glu Ala Lys Ser Tyr 
    50                  55                  60                  


Phe Glu Lys Ser Lys Glu Gln Leu Thr Pro Leu Ile Lys Lys Ala Gly 
65                  70                  75                  80  


Thr Glu Leu Val Asn Phe Leu Ser Tyr Phe Val Glu Leu Gly Thr His 
                85                  90                  95      


Pro Ala Thr Gln 
            100 


<210> 33  
<211> 338
<212> PRT
<213> Mycobacterium bovis

<400> 33  
Met Gln Leu Val Asp Arg Val Arg Gly Ala Val Thr Gly Met Ser Arg 
1               5                   10                  15      


Arg Leu Val Val Gly Ala Val Gly Ala Ala Leu Val Ser Gly Leu Val 
            20                  25                  30          


Gly Ala Val Gly Gly Thr Ala Thr Ala Gly Ala Phe Ser Arg Pro Gly 
        35                  40                  45              


Leu Pro Val Glu Tyr Leu Gln Val Pro Ser Pro Ser Met Gly Arg Asp 
    50                  55                  60                  


Ile Lys Val Gln Phe Gln Ser Gly Gly Ala Asn Ser Pro Ala Leu Tyr 
65                  70                  75                  80  


Leu Leu Asp Gly Leu Arg Ala Gln Asp Asp Phe Ser Gly Trp Asp Ile 
                85                  90                  95      


Asn Thr Pro Ala Phe Glu Trp Tyr Asp Gln Ser Gly Leu Ser Val Val 
            100                 105                 110         


Met Pro Val Gly Gly Gln Ser Ser Phe Tyr Ser Asp Trp Tyr Gln Pro 
        115                 120                 125             


Ala Cys Gly Lys Ala Gly Cys Gln Thr Tyr Lys Trp Glu Thr Phe Leu 
    130                 135                 140                 


Thr Ser Glu Leu Pro Gly Trp Leu Gln Ala Asn Arg His Val Lys Pro 
145                 150                 155                 160 


Thr Gly Ser Ala Val Val Gly Leu Ser Met Ala Ala Ser Ser Ala Leu 
                165                 170                 175     


Thr Leu Ala Ile Tyr His Pro Gln Gln Phe Val Tyr Ala Gly Ala Met 
            180                 185                 190         


Ser Gly Leu Leu Asp Pro Ser Gln Ala Met Gly Pro Thr Leu Ile Gly 
        195                 200                 205             


Leu Ala Met Gly Asp Ala Gly Gly Tyr Lys Ala Ser Asp Met Trp Gly 
    210                 215                 220                 


Pro Lys Glu Asp Pro Ala Trp Gln Arg Asn Asp Pro Leu Leu Asn Val 
225                 230                 235                 240 


Gly Lys Leu Ile Ala Asn Asn Thr Arg Val Trp Val Tyr Cys Gly Asn 
                245                 250                 255     


Gly Lys Pro Ser Asp Leu Gly Gly Asn Asn Leu Pro Ala Lys Phe Leu 
            260                 265                 270         


Glu Gly Phe Val Arg Thr Ser Asn Ile Lys Phe Gln Asp Ala Tyr Asn 
        275                 280                 285             


Ala Gly Gly Gly His Asn Gly Val Phe Asp Phe Pro Asp Ser Gly Thr 
    290                 295                 300                 


His Ser Trp Glu Tyr Trp Gly Ala Gln Leu Asn Ala Met Lys Pro Asp 
305                 310                 315                 320 


Leu Gln Arg Ala Leu Gly Ala Thr Pro Asn Thr Gly Pro Ala Pro Gln 
                325                 330                 335     


Gly Ala 
        


<210> 34  
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> MOD_RES
<222> (3)..(3)
<223> (NH(CH2)4CO)2-Asp

<400> 34  
Phe Pro Asp Phe Glu Pro Ile Pro Leu 
1               5                   


<210> 35  
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Pyro-Glu

<220>
<221> misc_feature
<222> (14)..(14)
<223> /note=C-term amidated"

<400> 35  
Glu Gln Arg Leu Gly Asn Gln Trp Ala Val Gly His Leu Leu 
1               5                   10                   


<210> 36  
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 36  
Leu Asp Val Pro 
1               


<210> 37  
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Alpha-Glu

<220>
<221> MOD_RES
<222> (10)..(11)
<223> Alpha-Asp

<400> 37  
Gly Glu Pro Pro Pro Gly Lys Pro Ala Asp Asp Ala Gly Leu 
1               5                   10                  


<210> 38  
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> MOD_RES
<222> (1)..(1)
<223> 5-oxo-Pro

<220>
<221> misc_feature
<222> (14)..(14)
<223> /note="C-term amidated"

<400> 38  
Pro Gln Arg Leu Gly Asn Gln Trp Ala Val Gly His Leu Met 
1               5                   10                  


<210> 39  
<211> 32
<212> PRT
<213> Homo sapiens

<400> 39  
Ser Pro Lys Met Val Gln Gly Ser Gly Cys Phe Gly Arg Lys Met Asp 
1               5                   10                  15      


Arg Ile Ser Ser Ser Ser Gly Leu Gly Cys Lys Val Leu Arg Arg His 
            20                  25                  30          


<210> 40  
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polypeptide"  

<400> 40  
Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys Pro Ser Leu Arg Asp Pro Arg Pro Asn Ala 
            20                  25                  30          


Pro Ser Thr Ser Ala 
        35          


<210> 41  
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polypeptide"  

<400> 41  
Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro 
1               5                   10                  15      


Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln 
            20                  25                  30      


<210> 42  
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 42  
Asn Leu Gly Val 
1               


<210> 43  
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Tyr(SO3)

<400> 43  
Tyr Met Gly Trp Met Asp 
1               5       


<210> 44  
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 44  
Thr Tyr Ile Cys Glu Val Glu Asp Gln Lys Glu Glu 
1               5                   10          


<210> 45  
<211> 180
<212> PRT
<213> Homo sapiens

<400> 45  
Met Gly Ile Pro Met Gly Lys Ser Met Leu Val Leu Leu Thr Phe Leu 
1               5                   10                  15      


Ala Phe Ala Ser Cys Cys Ile Ala Ala Tyr Arg Pro Ser Glu Thr Leu 
            20                  25                  30          


Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg 
        35                  40                  45              


Gly Phe Tyr Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg Ser Arg 
    50                  55                  60                  


Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu 
65                  70                  75                  80  


Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu Arg Asp Val Ser Thr 
                85                  90                  95      


Pro Pro Thr Val Leu Pro Asp Asn Phe Pro Arg Tyr Pro Val Gly Lys 
            100                 105                 110         


Phe Phe Gln Tyr Asp Thr Trp Lys Gln Ser Thr Gln Arg Leu Arg Arg 
        115                 120                 125             


Gly Leu Pro Ala Leu Leu Arg Ala Arg Arg Gly His Val Leu Ala Lys 
    130                 135                 140                 


Glu Leu Glu Ala Phe Arg Glu Ala Lys Arg His Arg Pro Leu Ile Ala 
145                 150                 155                 160 


Leu Pro Thr Gln Asp Pro Ala His Gly Gly Ala Pro Pro Glu Met Ala 
                165                 170                 175     


Ser Asn Arg Lys 
            180 


<210> 46  
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polypeptide"  


<220>
<221> misc_feature
<222> (37)..(37)
<223> /note="C-term amidated"

<400> 46  
Ala Cys Asp Thr Ala Thr Cys Val Thr His Arg Leu Ala Gly Leu Leu 
1               5                   10                  15      


Ser Arg Ser Gly Gly Val Val Lys Asn Asn Phe Val Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Lys Ala Phe 
        35          


<210> 47  
<211> 622
<212> PRT
<213> Homo sapiens

<400> 47  
Met Ala His Val Arg Gly Leu Gln Leu Pro Gly Cys Leu Ala Leu Ala 
1               5                   10                  15      


Ala Leu Cys Ser Leu Val His Ser Gln His Val Phe Leu Ala Pro Gln 
            20                  25                  30          


Gln Ala Arg Ser Leu Leu Gln Arg Val Arg Arg Ala Asn Thr Phe Leu 
        35                  40                  45              


Glu Glu Val Arg Lys Gly Asn Leu Glu Arg Glu Cys Val Glu Glu Thr 
    50                  55                  60                  


Cys Ser Tyr Glu Glu Ala Phe Glu Ala Leu Glu Ser Ser Thr Ala Thr 
65                  70                  75                  80  


Asp Val Phe Trp Ala Lys Tyr Thr Ala Cys Glu Thr Ala Arg Thr Pro 
                85                  90                  95      


Arg Asp Lys Leu Ala Ala Cys Leu Glu Gly Asn Cys Ala Glu Gly Leu 
            100                 105                 110         


Gly Thr Asn Tyr Arg Gly His Val Asn Ile Thr Arg Ser Gly Ile Glu 
        115                 120                 125             


Cys Gln Leu Trp Arg Ser Arg Tyr Pro His Lys Pro Glu Ile Asn Ser 
    130                 135                 140                 


Thr Thr His Pro Gly Ala Asp Leu Gln Glu Asn Phe Cys Arg Asn Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Thr Gly Pro Trp Cys Tyr Thr Thr Asp Pro Thr Val 
                165                 170                 175     


Arg Arg Gln Glu Cys Ser Ile Pro Val Cys Gly Gln Asp Gln Val Thr 
            180                 185                 190         


Val Ala Met Thr Pro Arg Ser Glu Gly Ser Ser Val Asn Leu Ser Pro 
        195                 200                 205             


Pro Leu Glu Gln Cys Val Pro Asp Arg Gly Gln Gln Tyr Gln Gly Arg 
    210                 215                 220                 


Leu Ala Val Thr Thr His Gly Leu Pro Cys Leu Ala Trp Ala Ser Ala 
225                 230                 235                 240 


Gln Ala Lys Ala Leu Ser Lys His Gln Asp Phe Asn Ser Ala Val Gln 
                245                 250                 255     


Leu Val Glu Asn Phe Cys Arg Asn Pro Asp Gly Asp Glu Glu Gly Val 
            260                 265                 270         


Trp Cys Tyr Val Ala Gly Lys Pro Gly Asp Phe Gly Tyr Cys Asp Leu 
        275                 280                 285             


Asn Tyr Cys Glu Glu Ala Val Glu Glu Glu Thr Gly Asp Gly Leu Asp 
    290                 295                 300                 


Glu Asp Ser Asp Arg Ala Ile Glu Gly Arg Thr Ala Thr Ser Glu Tyr 
305                 310                 315                 320 


Gln Thr Phe Phe Asn Pro Arg Thr Phe Gly Ser Gly Glu Ala Asp Cys 
                325                 330                 335     


Gly Leu Arg Pro Leu Phe Glu Lys Lys Ser Leu Glu Asp Lys Thr Glu 
            340                 345                 350         


Arg Glu Leu Leu Glu Ser Tyr Ile Asp Gly Arg Ile Val Glu Gly Ser 
        355                 360                 365             


Asp Ala Glu Ile Gly Met Ser Pro Trp Gln Val Met Leu Phe Arg Lys 
    370                 375                 380                 


Ser Pro Gln Glu Leu Leu Cys Gly Ala Ser Leu Ile Ser Asp Arg Trp 
385                 390                 395                 400 


Val Leu Thr Ala Ala His Cys Leu Leu Tyr Pro Pro Trp Asp Lys Asn 
                405                 410                 415     


Phe Thr Glu Asn Asp Leu Leu Val Arg Ile Gly Lys His Ser Arg Thr 
            420                 425                 430         


Arg Tyr Glu Arg Asn Ile Glu Lys Ile Ser Met Leu Glu Lys Ile Tyr 
        435                 440                 445             


Ile His Pro Arg Tyr Asn Trp Arg Glu Asn Leu Asp Arg Asp Ile Ala 
    450                 455                 460                 


Leu Met Lys Leu Lys Lys Pro Val Ala Phe Ser Asp Tyr Ile His Pro 
465                 470                 475                 480 


Val Cys Leu Pro Asp Arg Glu Thr Ala Ala Ser Leu Leu Gln Ala Gly 
                485                 490                 495     


Tyr Lys Gly Arg Val Thr Gly Trp Gly Asn Leu Lys Glu Thr Trp Thr 
            500                 505                 510         


Ala Asn Val Gly Lys Gly Gln Pro Ser Val Leu Gln Val Val Asn Leu 
        515                 520                 525             


Pro Ile Val Glu Arg Pro Val Cys Lys Asp Ser Thr Arg Ile Arg Ile 
    530                 535                 540                 


Thr Asp Asn Met Phe Cys Ala Gly Tyr Lys Pro Asp Glu Gly Lys Arg 
545                 550                 555                 560 


Gly Asp Ala Cys Glu Gly Asp Ser Gly Gly Pro Phe Val Met Lys Ser 
                565                 570                 575     


Pro Phe Asn Asn Arg Trp Tyr Gln Met Gly Ile Val Ser Trp Gly Glu 
            580                 585                 590         


Gly Cys Asp Arg Asp Gly Lys Tyr Gly Phe Tyr Thr His Val Phe Arg 
        595                 600                 605             


Leu Lys Lys Trp Ile Gln Lys Val Ile Asp Gln Phe Gly Glu 
    610                 615                 620         


<210> 48  
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> MOD_RES
<222> (8)..(8)
<223> Alpha-Asp

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Alpha-Glu

<400> 48  
Leu Gln Asn Arg Arg Gly Leu Asp Leu Leu Phe Leu Lys Glu Gly Gly 
1               5                   10                  15      


<210> 49  
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 49  
Thr Thr Ser Gln Val Arg Pro 
1               5           


<210> 50  
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Penicillaminyl-Thr

<400> 50  
Phe Cys Tyr Trp Arg Thr Thr
1               5       


<210> 51  
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 51  
Cys Val Phe Met 
1               


<210> 52  
<211> 32
<212> PRT
<213> Homo sapiens

<400> 52  
Cys Gly Asn Leu Ser Thr Cys Met Leu Gly Thr Tyr Thr Gln Asp Phe 
1               5                   10                  15      


Asn Lys Phe His Thr Phe Pro Gln Thr Ala Ile Gly Val Gly Ala Pro 
            20                  25                  30          


<210> 53  
<211> 32
<212> PRT
<213> Salmo salar


<220>
<221> misc_feature
<222> (32)..(32)
<223> /note="C-term amidated"

<400> 53  
Cys Ser Asn Leu Ser Thr Cys Val Leu Gly Lys Leu Ser Gln Glu Leu 
1               5                   10                  15      


His Lys Leu Gln Thr Tyr Pro Arg Thr Asn Thr Gly Ser Gly Thr Pro 
            20                  25                  30          


<210> 54  
<211> 60
<212> PRT
<213> Dendroaspis polylepis polylepis

<400> 54  
Arg Ile Cys Tyr Ile His Lys Ala Ser Leu Pro Arg Ala Thr Lys Thr 
1               5                   10                  15      


Cys Val Glu Asn Thr Cys Tyr Lys Met Phe Ile Arg Thr Gln Arg Glu 
            20                  25                  30          


Tyr Ile Ser Glu Arg Gly Cys Gly Cys Pro Thr Ala Met Trp Pro Tyr 
        35                  40                  45              


Gln Thr Glu Cys Cys Lys Gly Asp Arg Cys Asn Lys 
    50                  55                  60  


<210> 55  
<211> 320
<212> PRT
<213> Homo sapiens

<400> 55  
Met Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp 
1               5                   10                  15      


Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly 
            20                  25                  30          


Thr Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala 
        35                  40                  45              


Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp 
    50                  55                  60                  


Leu Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu 
65                  70                  75                  80  


Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu 
                85                  90                  95      


Lys His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu 
            100                 105                 110         


Ile Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Val 
        115                 120                 125             


Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp 
    130                 135                 140                 


Thr Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn 
145                 150                 155                 160 


Arg Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala 
                165                 170                 175     


Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu 
            180                 185                 190         


Lys Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys 
        195                 200                 205             


Val Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr 
    210                 215                 220                 


Ile Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val 
225                 230                 235                 240 


Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr 
                245                 250                 255     


Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val 
            260                 265                 270         


Met Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe 
        275                 280                 285             


Arg Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr 
    290                 295                 300                 


Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp 
305                 310                 315                 320 


<210> 56  
<211> 31
<212> PRT
<213> Sus scrofa

<400> 56  
Ser Trp Leu Ser Lys Thr Ala Lys Lys Leu Glu Asn Ser Ala Lys Lys 
1               5                   10                  15      


Arg Ile Ser Glu Gly Ile Ala Ile Ala Ile Gln Gly Gly Pro Arg 
            20                  25                  30      


<210> 57  
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> MOD_RES
<222> (3)..(3)
<223> N-methyl-Val

<220>
<221> misc_feature
<222> (5)..(5)
<223> /note="C-term amidated"

<400> 57  
Val Val Val Pro Pro 
1               5   


<210> 58  
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Pyro-Glu

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Tyr(SO3H)

<220>
<221> misc_feature
<222> (10)..(10)
<223> /note="C-term amidated"

<400> 58  
Glu Gln Asp Tyr Thr Gly Trp Met Asp Phe 
1               5                   10


<210> 59  
<211> 41
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polypeptide"  

<400> 59  
Ser Gln Glu Pro Pro Ile Ser Leu Asp Leu Thr Phe His Leu Leu Arg 
1               5                   10                  15      


Glu Val Leu Glu Met Thr Lys Ala Asp Gln Leu Ala Gln Gln Ala His 
            20                  25                  30          


Ser Asn Arg Lys Leu Leu Asp Ile Ala 
        35                  40      


<210> 60  
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Beta-Ala

<400> 60  
Ala Arg Gly Phe Phe 
1               5   


<210> 61  
<211> 41
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polypeptide"  


<220>
<221> MOD_RES
<222> (26)..(26)
<223> Alph-Glu

<400> 61  
Met Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gln Ile Val Gln 
1               5                   10                  15      


Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu 
            20                  25                  30          


Gln Leu Thr Val Trp Gly Ile Lys Gln 
        35                  40      


<210> 62  
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 62  
Arg Gly Asp Ser 
1               


<210> 63  
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 63  
Tyr Gly Gly Phe Leu Arg Arg Ile Arg Pro Lys Leu Lys Trp Asp Asn 
1               5                   10                  15      


Gln 
    


<210> 64  
<211> 94
<212> PRT
<213> Homo sapiens

<400> 64  
Met Arg Thr Leu Ala Ile Leu Ala Ala Ile Leu Leu Val Ala Leu Gln 
1               5                   10                  15      


Ala Gln Ala Glu Pro Leu Gln Ala Arg Ala Asp Glu Val Ala Ala Ala 
            20                  25                  30          


Pro Glu Gln Ile Ala Ala Asp Ile Pro Glu Val Val Val Ser Leu Ala 
        35                  40                  45              


Trp Asp Glu Ser Leu Ala Pro Lys His Pro Gly Ser Arg Lys Asn Met 
    50                  55                  60                  


Asp Cys Tyr Cys Arg Ile Pro Ala Cys Ile Ala Gly Glu Arg Arg Tyr 
65                  70                  75                  80  


Gly Thr Cys Ile Tyr Gln Gly Arg Leu Trp Ala Phe Cys Cys 
                85                  90                  


<210> 65  
<211> 60
<212> PRT
<213> Ornithodoros moubata

<400> 65  
Ser Asp Asp Lys Cys Gln Gly Arg Pro Met Tyr Gly Cys Arg Glu Asp 
1               5                   10                  15      


Asp Asp Ser Val Phe Gly Trp Thr Tyr Asp Ser Asn His Gly Gln Cys 
            20                  25                  30          


Trp Lys Gly Ser Tyr Cys Lys His Arg Arg Gln Pro Ser Asn Tyr Phe 
        35                  40                  45              


Ala Ser Gln Gln Glu Cys Arg Asn Thr Cys Gly Ala 
    50                  55                  60  


<210> 66  
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> MOD_RES
<222> (7)..(7)
<223> N2-methyl-Arg

<400> 66  
Tyr Gly Gly Phe Leu Arg Arg 
1               5               


<210> 67  
<211> 60
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polypeptide"  

<400> 67  
Glu Ala Met His Ser Phe Cys Ala Phe Lys Ala Asp Asp Gly Pro Cys 
1               5                   10                  15      


Arg Ala Ala His Pro Arg Trp Phe Phe Asn Ile Phe Thr Arg Gln Cys 
            20                  25                  30          


Glu Glu Phe Ile Tyr Gly Gly Cys Glu Gly Asn Gln Asn Arg Phe Glu 
        35                  40                  45              


Ser Leu Glu Glu Cys Lys Lys Met Cys Thr Arg Asp 
    50                  55                  60  


<210> 68  
<211> 21
<212> PRT
<213> Homo sapiens

<400> 68  
Met Arg Ala Ser Ser Phe Leu Ile Val Val Val Phe Leu Ile Ala Gly 
1               5                   10                  15      


Thr Leu Val Leu Glu 
            20      


<210> 69  
<211> 57
<212> PRT
<213> Homo sapiens

<400> 69  
Ala Gln Glu Pro Val Lys Gly Pro Val Ser Thr Lys Pro Gly Ser Cys 
1               5                   10                  15      


Pro Ile Ile Leu Ile Arg Cys Ala Met Leu Asn Pro Pro Asn Arg Cys 
            20                  25                  30          


Leu Lys Asp Thr Asp Cys Pro Gly Ile Lys Lys Cys Cys Glu Gly Ser 
        35                  40                  45              


Cys Gly Met Ala Cys Phe Val Pro Gln 
    50                  55          


<210> 70  
<211> 31
<212> PRT
<213> Homo sapiens


<220>
<221> misc_feature
<222> (31)..(31)
<223> /note="C-term amidated"

<400> 70  
Ser Asn Leu Ser Thr Asn Val Leu Gly Lys Leu Ser Gln Glu Leu His 
1               5                   10                  15      


Lys Leu Gln Thr Tyr Pro Arg Thr Asn Val Gly Ala Gly Thr Pro 
            20                  25                  30      


<210> 71  
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> MOD_RES
<222> (1)..(1)
<223> 5-oxo-Pro

<220>
<221> misc_feature
<222> (12)..(12)
<223> /note="C-term amidated"

<400> 71  
Pro Pro Ser Lys Asp Ala Phe Ala Ile Gly Leu Met
1               5                   10      


<210> 72  
<211> 31
<212> PRT
<213> Homo sapiens

<400> 72  
Tyr Gly Gly Phe Met Thr Ser Glu Lys Ser Gln Thr Pro Leu Val Thr 
1               5                   10                  15      


Leu Phe Lys Asn Ala Ile Ile Lys Asn Ala Tyr Lys Lys Gly Glu 
            20                  25                  30      


<210> 73  
<211> 482
<212> PRT
<213> Homo sapiens

<400> 73  
Met Ala Ala Leu Met Thr Pro Gly Thr Gly Ala Pro Pro Ala Pro Gly 
1               5                   10                  15      


Asp Phe Ser Gly Glu Gly Ser Gln Gly Leu Pro Asp Pro Ser Pro Glu 
            20                  25                  30          


Pro Lys Gln Leu Pro Glu Leu Ile Arg Met Lys Arg Asp Gly Gly Arg 
        35                  40                  45              


Leu Ser Glu Ala Asp Ile Arg Gly Phe Val Ala Ala Val Val Asn Gly 
    50                  55                  60                  


Ser Ala Gln Gly Ala Gln Ile Gly Ala Met Leu Met Ala Ile Arg Leu 
65                  70                  75                  80  


Arg Gly Met Asp Leu Glu Glu Thr Ser Val Leu Thr Gln Ala Leu Ala 
                85                  90                  95      


Gln Ser Gly Gln Gln Leu Glu Trp Pro Glu Ala Trp Arg Gln Gln Leu 
            100                 105                 110         


Val Asp Lys His Ser Thr Gly Gly Val Gly Asp Lys Val Ser Leu Val 
        115                 120                 125             


Leu Ala Pro Ala Leu Ala Ala Cys Gly Cys Lys Val Pro Met Ile Ser 
    130                 135                 140                 


Gly Arg Gly Leu Gly His Thr Gly Gly Thr Leu Asp Lys Leu Glu Ser 
145                 150                 155                 160 


Ile Pro Gly Phe Asn Val Ile Gln Ser Pro Glu Gln Met Gln Val Leu 
                165                 170                 175     


Leu Asp Gln Ala Gly Cys Cys Ile Val Gly Gln Ser Glu Gln Leu Val 
            180                 185                 190         


Pro Ala Asp Gly Ile Leu Tyr Ala Ala Arg Asp Val Thr Ala Thr Val 
        195                 200                 205             


Asp Ser Leu Pro Leu Ile Thr Ala Ser Ile Leu Ser Lys Lys Leu Val 
    210                 215                 220                 


Glu Gly Leu Ser Ala Leu Val Val Asp Val Lys Phe Gly Gly Ala Ala 
225                 230                 235                 240 


Val Phe Pro Asn Gln Glu Gln Ala Arg Glu Leu Ala Lys Thr Leu Val 
                245                 250                 255     


Gly Val Gly Ala Ser Leu Gly Leu Arg Val Ala Ala Ala Leu Thr Ala 
            260                 265                 270         


Met Asp Lys Pro Leu Gly Arg Cys Val Gly His Ala Leu Glu Val Glu 
        275                 280                 285             


Glu Ala Leu Leu Cys Met Asp Gly Ala Gly Pro Pro Asp Leu Arg Asp 
    290                 295                 300                 


Leu Val Thr Thr Leu Gly Gly Ala Leu Leu Trp Leu Ser Gly His Ala 
305                 310                 315                 320 


Gly Thr Gln Ala Gln Gly Ala Ala Arg Val Ala Ala Ala Leu Asp Asp 
                325                 330                 335     


Gly Ser Ala Leu Gly Arg Phe Glu Arg Met Leu Ala Ala Gln Gly Val 
            340                 345                 350         


Asp Pro Gly Leu Ala Arg Ala Leu Cys Ser Gly Ser Pro Ala Glu Arg 
        355                 360                 365             


Arg Gln Leu Leu Pro Arg Ala Arg Glu Gln Glu Glu Leu Leu Ala Pro 
    370                 375                 380                 


Ala Asp Gly Thr Val Glu Leu Val Arg Ala Leu Pro Leu Ala Leu Val 
385                 390                 395                 400 


Leu His Glu Leu Gly Ala Gly Arg Ser Arg Ala Gly Glu Pro Leu Arg 
                405                 410                 415     


Leu Gly Val Gly Ala Glu Leu Leu Val Asp Val Gly Gln Arg Leu Arg 
            420                 425                 430         


Arg Gly Thr Pro Trp Leu Arg Val His Arg Asp Gly Pro Ala Leu Ser 
        435                 440                 445             


Gly Pro Gln Ser Arg Ala Leu Gln Glu Ala Leu Val Leu Ser Asp Arg 
    450                 455                 460                 


Ala Pro Phe Ala Ala Pro Ser Pro Phe Ala Glu Leu Val Leu Pro Pro 
465                 470                 475                 480 


Gln Gln 
        


<210> 74  
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> misc_feature
<222> (5)..(5)
<223> /note="C-term amidated"

<400> 74  
Gly Asp Trp Pro Cys 
1               5   


<210> 75  
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 75  
Gln His Asn Pro Arg 
1               5   


<210> 76  
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 76  
Gly Arg Gly Asp Ser 
1               5   


<210> 77  
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 77  
Tyr Tyr Trp Ile Gly Ile Arg 
1               5           


<210> 78  
<211> 92
<212> PRT
<213> Homo sapiens

<400> 78  
Met Lys Pro Ile Gln Lys Leu Leu Ala Gly Leu Ile Leu Leu Thr Trp 
1               5                   10                  15      


Cys Val Glu Gly Cys Ser Ser Gln His Trp Ser Tyr Gly Leu Arg Pro 
            20                  25                  30          


Gly Gly Lys Arg Asp Ala Glu Asn Leu Ile Asp Ser Phe Gln Glu Ile 
        35                  40                  45              


Val Lys Glu Val Gly Gln Leu Ala Glu Thr Gln Arg Phe Glu Cys Thr 
    50                  55                  60                  


Thr His Gln Pro Arg Ser Pro Leu Arg Asp Leu Lys Gly Ala Leu Glu 
65                  70                  75                  80  


Ser Leu Ile Glu Glu Glu Thr Gly Gln Lys Lys Ile 
                85                  90          


<210> 79  
<211> 44
<212> PRT
<213> Homo sapiens

<400> 79  
Met Pro Leu Trp Val Phe Phe Phe Val Ile Leu Thr Leu Ser Asn Ser 
1               5                   10                  15      


Ser His Cys Ser Pro Pro Pro Pro Leu Thr Leu Arg Met Arg Arg Tyr 
            20                  25                  30          


Ala Asp Ala Ile Phe Thr Asn Ser Tyr Arg Lys Val 
        35                  40                  


<210> 80  
<211> 107
<212> PRT
<213> Homo sapiens

<400> 80  
Met Pro Leu Trp Val Phe Phe Phe Val Ile Leu Thr Leu Ser Asn Ser 
1               5                   10                  15      


Ser His Cys Ser Pro Pro Pro Pro Leu Thr Leu Arg Met Arg Arg Tyr 
            20                  25                  30          


Ala Asp Ala Ile Phe Thr Asn Ser Tyr Arg Lys Val Leu Gly Gln Leu 
        35                  40                  45              


Ser Ala Arg Lys Leu Leu Gln Asp Ile Met Ser Arg Gln Gln Gly Glu 
    50                  55                  60                  


Ser Asn Gln Glu Arg Gly Ala Arg Ala Arg Leu Gly Arg Gln Val Asp 
65                  70                  75                  80  


Ser Met Trp Ala Glu Gln Lys Gln Met Glu Leu Glu Ser Ile Leu Val 
                85                  90                  95      


Ala Leu Leu Gln Lys His Arg Asn Ser Gln Gly 
            100                 105         


<210> 81  
<211> 123
<212> PRT
<213> Homo sapiens

<400> 81  
Met Ala Arg Gly Ser Ala Leu Leu Leu Ala Ser Leu Leu Leu Ala Ala 
1               5                   10                  15      


Ala Leu Ser Ala Ser Ala Gly Leu Trp Ser Pro Ala Lys Glu Lys Arg 
            20                  25                  30          


Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Pro His Ala Val 
        35                  40                  45              


Gly Asn His Arg Ser Phe Ser Asp Lys Asn Gly Leu Thr Ser Lys Arg 
    50                  55                  60                  


Glu Leu Arg Pro Glu Asp Asp Met Lys Pro Gly Ser Phe Asp Arg Ser 
65                  70                  75                  80  


Ile Pro Glu Asn Asn Ile Met Arg Thr Ile Ile Glu Phe Leu Ser Phe 
                85                  90                  95      


Leu His Leu Lys Glu Ala Gly Ala Leu Asp Arg Leu Leu Asp Leu Pro 
            100                 105                 110         


Ala Ala Ala Ser Ser Glu Asp Ile Glu Arg Ser 
        115                 120             


<210> 82  
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> misc_feature
<222> (7)..(7)
<223> /note="C-term amidated"

<400> 82  
Glu Ala Tyr Gly Tyr Met Asp 
1               5           


<210> 83  
<211> 180
<212> PRT
<213> Homo sapiens

<400> 83  
Met Lys Ser Ile Tyr Phe Val Ala Gly Leu Phe Val Met Leu Val Gln 
1               5                   10                  15      


Gly Ser Trp Gln Arg Ser Leu Gln Asp Thr Glu Glu Lys Ser Arg Ser 
            20                  25                  30          


Phe Ser Ala Ser Gln Ala Asp Pro Leu Ser Asp Pro Asp Gln Met Asn 
        35                  40                  45              


Glu Asp Lys Arg His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys 
    50                  55                  60                  


Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn 
65                  70                  75                  80  


Thr Lys Arg Asn Arg Asn Asn Ile Ala Lys Arg His Asp Glu Phe Glu 
                85                  90                  95      


Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu 
            100                 105                 110         


Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
        115                 120                 125             


Arg Arg Asp Phe Pro Glu Glu Val Ala Ile Val Glu Glu Leu Gly Arg 
    130                 135                 140                 


Arg His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp 
145                 150                 155                 160 


Asn Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile 
                165                 170                 175     


Thr Asp Arg Lys 
            180 


<210> 84  
<211> 29
<212> PRT
<213> Homo sapiens

<400> 84  
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210> 85  
<211> 92
<212> PRT
<213> Homo sapiens

<400> 85  
Met Lys Pro Ile Gln Lys Leu Leu Ala Gly Leu Ile Leu Leu Thr Trp 
1               5                   10                  15      


Cys Val Glu Gly Cys Ser Ser Gln His Trp Ser Tyr Gly Leu Arg Pro 
            20                  25                  30          


Gly Gly Lys Arg Asp Ala Glu Asn Leu Ile Asp Ser Phe Gln Glu Ile 
        35                  40                  45              


Val Lys Glu Val Gly Gln Leu Ala Glu Thr Gln Arg Phe Glu Cys Thr 
    50                  55                  60                  


Thr His Gln Pro Arg Ser Pro Leu Arg Asp Leu Lys Gly Ala Leu Glu 
65                  70                  75                  80  


Ser Leu Ile Glu Glu Glu Thr Gly Gln Lys Lys Ile 
                85                  90          


<210> 86  
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> MOD_RES
<222> (1)..(1)
<223> 5-oxo-His

<220>
<221> misc_feature
<222> (9)..(9)
<223> /note="C-term amidated"

<400> 86  
His Trp Ser Tyr Gly Leu Arg Pro Gly 
1               5                   


<210> 87  
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 87  
Arg Gly Gly Leu Cys Tyr Cys Arg Gly Arg Phe Cys Val Cys Val Gly 
1               5                   10                  15      


<210> 88  
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> MOD_RES
<222> (2)..(2)
<223> (4R)-4-hydroxy-Pro

<400> 88  
Phe Pro Arg Gly 
1               


<210> 89  
<211> 140
<212> PRT
<213> Homo sapiens

<400> 89  
Met Gly Phe Gln Lys Phe Ser Pro Phe Leu Ala Leu Ser Ile Leu Val 
1               5                   10                  15      


Leu Leu Gln Ala Gly Ser Leu His Ala Ala Pro Phe Arg Ser Ala Leu 
            20                  25                  30          


Glu Ser Ser Pro Ala Asp Pro Ala Thr Leu Ser Glu Asp Glu Ala Arg 
        35                  40                  45              


Leu Leu Leu Ala Ala Leu Val Gln Asp Tyr Val Gln Met Lys Ala Ser 
    50                  55                  60                  


Glu Leu Glu Gln Glu Gln Glu Arg Glu Gly Ser Ser Leu Asp Ser Pro 
65                  70                  75                  80  


Arg Ser Lys Arg Cys Gly Asn Leu Ser Thr Cys Met Leu Gly Thr Tyr 
                85                  90                  95      


Thr Gln Asp Phe Asn Lys Phe His Thr Phe Pro Gln Thr Ala Ile Gly 
            100                 105                 110         


Val Gly Ala Pro Gly Lys Lys Arg Asp Met Ser Ser Asp Leu Glu Arg 
        115                 120                 125             


Asp His Arg Pro His Val Ser Met Pro Gln Ala Asn 
    130                 135                 140 


<210> 90  
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 90  
Arg Met Phe Arg Tyr 
1               5   


<210> 91  
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> MOD_RES
<222> (6)..(6)
<223> (3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid

<220>
<221> misc_feature
<222> (8)..(8)
<223> /note=C-term amidated"

<400> 91  
Val His Pro Phe His Xaa Leu Phe 
1               5       


<210> 92  
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Alpha-Asp

<400> 92  
Phe Leu Asp Val Pro Ala Ala Lys 
1               5               


<210> 93  
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  
	
<400> 93  
Pro Val Thr Lys Pro Gln 
1               5       


<210> 94  
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> misc_feature
<222> (6)..(6)
<223> /note="C-term amidated"

<400> 94  
Ser Ile Lys Val Ala Val 
1               5       


<210> 95  
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 95  
Tyr Ile Gly Ser Arg 
1               5   


<210> 96  
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 96  
Ile Leu Arg Trp Pro Trp Trp Pro Trp Arg Arg 
1               5                   10      


<210> 97  
<211> 304
<212> PRT
<213> Homo sapiens

<400> 97  
Met Gly Asn His Ala Gly Lys Arg Glu Leu Asn Ala Glu Lys Ala Ser 
1               5                   10                  15      


Thr Asn Ser Glu Thr Asn Arg Gly Glu Ser Glu Lys Lys Arg Asn Leu 
            20                  25                  30          


Gly Glu Leu Ser Arg Thr Thr Ser Glu Asp Asn Glu Val Phe Gly Glu 
        35                  40                  45              


Ala Asp Ala Asn Gln Asn Asn Gly Thr Ser Ser Gln Asp Thr Ala Val 
    50                  55                  60                  


Thr Asp Ser Lys Arg Thr Ala Asp Pro Lys Asn Ala Trp Gln Asp Ala 
65                  70                  75                  80  


His Pro Ala Asp Pro Gly Ser Arg Pro His Leu Ile Arg Leu Phe Ser 
                85                  90                  95      


Arg Asp Ala Pro Gly Arg Glu Asp Asn Thr Phe Lys Asp Arg Pro Ser 
            100                 105                 110         


Glu Ser Asp Glu Leu Gln Thr Ile Gln Glu Asp Ser Ala Ala Thr Ser 
        115                 120                 125             


Glu Ser Leu Asp Val Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His 
    130                 135                 140                 


Gly Ser Lys Tyr Leu Ala Thr Ala Ser Thr Met Asp His Ala Arg His 
145                 150                 155                 160 


Gly Phe Leu Pro Arg His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly 
                165                 170                 175     


Arg Phe Phe Gly Gly Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys 
            180                 185                 190         


Asp Ser His His Pro Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln 
        195                 200                 205             


Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro Val Val His Phe Phe 
    210                 215                 220                 


Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly 
225                 230                 235                 240 


Arg Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg 
                245                 250                 255     


Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp Tyr Lys Ser Ala His 
            260                 265                 270         


Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe 
        275                 280                 285             


Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser Pro Met Ala Arg Arg 
    290                 295                 300                 


<210> 98  
<211> 197
<212> PRT
<213> Homo sapiens

<400> 98  
Met Gly Asn His Ala Gly Lys Arg Glu Leu Asn Ala Glu Lys Ala Ser 
1               5                   10                  15      


Thr Asn Ser Glu Thr Asn Arg Gly Glu Ser Glu Lys Lys Arg Asn Leu 
            20                  25                  30          


Gly Glu Leu Ser Arg Thr Thr Ser Glu Asp Asn Glu Val Phe Gly Glu 
        35                  40                  45              


Ala Asp Ala Asn Gln Asn Asn Gly Thr Ser Ser Gln Asp Thr Ala Val 
    50                  55                  60                  


Thr Asp Ser Lys Arg Thr Ala Asp Pro Lys Asn Ala Trp Gln Asp Ala 
65                  70                  75                  80  


His Pro Ala Asp Pro Gly Ser Arg Pro His Leu Ile Arg Leu Phe Ser 
                85                  90                  95      


Arg Asp Ala Pro Gly Arg Glu Asp Asn Thr Phe Lys Asp Arg Pro Ser 
            100                 105                 110         


Glu Ser Asp Glu Leu Gln Thr Ile Gln Glu Asp Ser Ala Ala Thr Ser 
        115                 120                 125             


Glu Ser Leu Asp Val Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His 
    130                 135                 140                 


Gly Ser Lys Tyr Leu Ala Thr Ala Ser Thr Met Asp His Ala Arg His 
145                 150                 155                 160 


Gly Phe Leu Pro Arg His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly 
                165                 170                 175     


Arg Phe Phe Gly Gly Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys 
            180                 185                 190         


Val Ser Ser Glu Glu 
        195         


<210> 99  
<211> 197
<212> PRT
<213> Homo sapiens

<400> 99  
Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu 
1               5                   10                  15      


Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg 
            20                  25                  30          


His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly 
        35                  40                  45              


Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Val Pro Trp Leu Lys 
    50                  55                  60                  


Pro Gly Arg Ser Pro Leu Pro Ser His Ala Arg Ser Gln Pro Gly Leu 
65                  70                  75                  80  


Cys Asn Met Tyr Lys Asp Ser His His Pro Ala Arg Thr Ala His Tyr 
                85                  90                  95      


Gly Ser Leu Pro Gln Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro 
            100                 105                 110         


Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro 
        115                 120                 125             


Ser Gln Gly Lys Gly Arg Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly 
    130                 135                 140                 


Ala Glu Gly Gln Arg Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp 
145                 150                 155                 160 


Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr 
                165                 170                 175     


Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser 
            180                 185                 190         


Pro Met Ala Arg Arg 
        195         


<210> 100  
<211> 22
<212> PRT
<213> Homo sapiens

<400> 100  
Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu 
1               5                   10                  15      


Ala Thr Ala Ser Thr Met 
            20          


<210> 101  
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 101  
Gly Pro Leu Ala 
1               


<210> 102  
<211> 4
<212> PRT
<213> Homo sapiens

<400> 102  
Asn Ala Gly Ala 
1               


<210> 103  
<211> 487
<212> PRT
<213> Homo sapiens

<400> 103  
Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Ala 
1               5                   10                  15      


Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val 
            20                  25                  30          


Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala 
        35                  40                  45              


Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys 
    50                  55                  60                  


Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly 
65                  70                  75                  80  


His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser 
                85                  90                  95      


Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser 
            100                 105                 110         


Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe 
        115                 120                 125             


Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile 
    130                 135                 140                 


Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr 
145                 150                 155                 160 


Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His 
                165                 170                 175     


Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys 
            180                 185                 190         


Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys 
        195                 200                 205             


Val Thr Asn Ser Val Ser Ser Glu Leu Gln Pro Tyr Phe Gln Thr Leu 
    210                 215                 220                 


Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu 
225                 230                 235                 240 


Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys 
                245                 250                 255     


Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro 
            260                 265                 270         


Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly 
        275                 280                 285             


Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala 
    290                 295                 300                 


Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser 
305                 310                 315                 320 


Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val 
                325                 330                 335     


Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser 
            340                 345                 350         


Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro 
        355                 360                 365             


Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala 
    370                 375                 380                 


Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser 
385                 390                 395                 400 


Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu 
                405                 410                 415     


Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu 
            420                 425                 430         


Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val 
        435                 440                 445             


Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val 
    450                 455                 460                 


Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe 
465                 470                 475                 480 


Gly Ala Asp Val Val Tyr Lys 
                485         


<210> 104  
<211> 31
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Alpha-Glu

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Alpha-Asp

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Alpha-Glu

<220>
<221> MOD_RES
<222> (20)..(20)
<223> N6-N-(1-oxohexadecyl)-gamma-Glu

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Alpha-Glu

<400> 104  
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Glu Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg 
            20                  25                  30      


<210> 105  
<211> 70
<212> PRT
<213> Homo sapiens

<400> 105  
Ser Phe Lys Ile Lys His Leu Gly Lys Gly His Tyr Ser Phe Tyr Ser 
1               5                   10                  15      


Met Asp Ile Arg Glu Phe Gln Leu Pro Ser Ser Gln Ile Ser Met Val 
            20                  25                  30          


Pro Asn Val Gly Leu Lys Phe Ser Ile Ser Asn Ala Asn Ile Lys Ile 
        35                  40                  45              


Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe Leu Lys Met Ser Gly Asn 
    50                  55                  60                  


Phe Asp Leu Ser Ile Glu 
65                  70  


<210> 106  
<211> 70
<212> PRT
<213> Homo sapiens

<400> 106  
Gly Met Ser Ile Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser 
1               5                   10                  15      


Gly Lys Pro Thr Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser 
            20                  25                  30          


Val His Val His Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu 
        35                  40                  45              


Phe His Lys Lys Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln 
    50                  55                  60                  


Val Cys Glu Lys Val Thr 
65                  70  


<210> 107  
<211> 21
<212> PRT
<213> Homo sapiens

<400> 107  
Cys Leu Gly Val Gly Ser Cys Asn Asp Phe Ala Gly Cys Gly Tyr Ala 
1               5                   10                  15      


Ile Val Cys Phe Trp 
            20      


<210> 108  
<211> 70
<212> PRT
<213> Homo sapiens

<400> 108  
Asn Ser Val Ser Ser Glu Leu Gln Pro Tyr Phe Gln Thr Leu Pro Val 
1               5                   10                  15      


Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu Val Ala 
            20                  25                  30          


Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys Gly Glu 
        35                  40                  45              


Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro Pro Val 
    50                  55                  60                  


Met Glu Phe Pro Ala Ala 
65                  70  


<210> 109  
<211> 70
<212> PRT
<213> Homo sapiens

<400> 109  
His Asp Arg Met Val Tyr Leu Gly Leu Ser Asp Tyr Phe Phe Asn Thr 
1               5                   10                  15      


Ala Gly Leu Val Tyr Gln Glu Ala Gly Val Leu Lys Met Thr Leu Arg 
            20                  25                  30          


Asp Asp Met Ile Pro Lys Glu Ser Lys Phe Arg Leu Thr Thr Lys Phe 
        35                  40                  45              


Phe Gly Thr Phe Leu Pro Glu Val Ala Lys Lys Phe Pro Asn Met Lys 
    50                  55                  60                  


Ile Gln Ile His Val Ser 
65                  70  


<210> 110  
<211> 70
<212> PRT
<213> Homo sapiens

<400> 110  
Ala Ser Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe 
1               5                   10                  15      


Tyr Pro Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser 
            20                  25                  30          


Leu Ala Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu 
        35                  40                  45              


Val Ser Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg 
    50                  55                  60                  


Leu Leu Leu Glu Leu Lys 
65                  70  


<210> 111  
<211> 67
<212> PRT
<213> Homo sapiens

<400> 111  
His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu Gln Asp Ile Met 
1               5                   10                  15      


Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val Asn Glu Lys Leu 
            20                  25                  30          


Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val Gln Leu Tyr Asn 
        35                  40                  45              


Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe Gly Ala Asp Val 
    50                  55                  60                  


Val Tyr Lys 
65          


<210> 112  
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 112  
Gly Glu Pro Pro Pro Gly Lys Pro Ala Asp Asp Ala Gly Leu Val 
1               5                   10                  15  


<210> 113  
<211> 6
<212> PRT
<213> Homo sapiens

<400> 113  
Asp Leu Gln Val Phe Val 
1               5       


<210> 114  
<211> 5
<212> PRT
<213> Homo sapiens

<400> 114  
Gly Glu Lys Lys Asp 
1               5   


<210> 115  
<211> 5
<212> PRT
<213> Homo sapiens

<400> 115  
Ala Thr His Glu Ser 
1               5   


<210> 116  
<211> 6
<212> PRT
<213> Homo sapiens

<400> 116  
Cys Leu Pro Val Ser Gly 
1               5       


<210> 117  
<211> 6
<212> PRT
<213> Homo sapiens

<400> 117  
Leu Pro Val Ser Gly Ser 
1               5       


<210> 118  
<211> 6
<212> PRT
<213> Homo sapiens

<400> 118  
Pro Cys His Ala Pro Pro 
1               5       


<210> 119  
<211> 8
<212> PRT
<213> Homo sapiens

<400> 119  
Gly Gly His Asp Leu Glu Ser Gly 
1               5               


<210> 120  
<211> 6
<212> PRT
<213> Homo sapiens

<400> 120  
Asp Asp Leu Gln Val Phe 
1               5       


<210> 121  
<211> 5
<212> PRT
<213> Homo sapiens

<400> 121  
Pro Leu Thr Ser Gly 
1               5   


<210> 122  
<211> 8
<212> PRT
<213> Homo sapiens

<400> 122  
Leu Ile His Phe Glu Glu Gly Val 
1               5               


<210> 123  
<211> 7
<212> PRT
<213> Homo sapiens

<400> 123  
Gly Glu Phe Ser Tyr Asp Ser 
1               5           


<210> 124  
<211> 7
<212> PRT
<213> Homo sapiens

<400> 124  
His Ala Pro Pro Leu Thr Ser 
1               5           


<210> 125  
<211> 7
<212> PRT
<213> Homo sapiens

<400> 125  
Asp Leu Glu Ser Gly Glu Phe 
1               5           


<210> 126  
<211> 8
<212> PRT
<213> Homo sapiens

<400> 126  
Gly Glu Phe Ser Val Cys Asp Ser 
1               5               


<210> 127  
<211> 10
<212> PRT
<213> Homo sapiens

<400> 127  
Lys Lys Gly Glu Phe Ser Val Ala Asp Ser 
1               5                   10  


<210> 128  
<211> 9
<212> PRT
<213> Homo sapiens

<400> 128  
Lys Lys Gly Glu Phe Tyr Cys Ser Arg 
1               5                   


<210> 129  
<211> 13
<212> PRT
<213> Homo sapiens

<400> 129  
Gly Leu Arg Val Arg Val Trp Asn Gly Lys Phe Pro Lys 
1               5                   10              


<210> 130  
<211> 16
<212> PRT
<213> Homo sapiens

<400> 130  
Gly Val Ala Phe Glu Glu Ala Pro Asp Asp His Ser Phe Phe Leu Phe 
1               5                   10                  15      


<210> 131  
<211> 7
<212> PRT
<213> Homo sapiens

<400> 131  
Gly Gly His Asp Leu Ser Gly 
1               5           


<210> 132  
<211> 8
<212> PRT
<213> Homo sapiens

<400> 132  
Gly Gly His Asp Leu Glu Ser Gly 
1               5               


<210> 133  
<211> 14
<212> PRT
<213> Homo sapiens

<400> 133  
Gly Gly His Asp Leu Glu Ser Gly Glu Phe Ser Tyr Asp Ser 
1               5                   10                  


<210> 134  
<211> 14
<212> PRT
<213> Homo sapiens

<400> 134  
Gly Gly Ser Asp Leu Ser Gly Glu Phe Ser Val Cys Asp Ser 
1               5                   10                  


<210> 135  
<211> 15
<212> PRT
<213> Homo sapiens

<400> 135  
Gly Gly Ser Asp Leu Ser Gly Gly Glu Phe Ser Val Cys Asp Ser 
1               5                   10                  15  


<210> 136  
<211> 15
<212> PRT
<213> Homo sapiens

<400> 136  
Gly Gly Ser Asp Leu Ser Gly Gly Glu Phe Ser Val Ala Asp Ser 
1               5                   10                  15  


<210> 137  
<211> 14
<212> PRT
<213> Homo sapiens

<400> 137  
Gly Gly Ser Asp Leu Ser Gly Glu Phe Ser Val Ala Asp Ser 
1               5                   10                  


<210> 138  
<211> 6
<212> PRT
<213> Homo sapiens

<400> 138  
Glu Thr Leu Gln Phe Arg 
1               5       


<210> 139  
<211> 8
<212> PRT
<213> Homo sapiens

<400> 139  
Lys Lys Glu Thr Leu Gln Phe Arg 
1               5               


<210> 140  
<211> 8
<212> PRT
<213> Homo sapiens

<400> 140  
Glu Thr Leu Gln Phe Arg Lys Lys 
1               5               


<210> 141  
<211> 9
<212> PRT
<213> Homo sapiens

<400> 141  
Lys Ala Ser Thr Thr Thr Asn Tyr Thr 
1               5                   


<210> 142  
<211> 13
<212> PRT
<213> Homo sapiens

<400> 142  
Ala Leu Lys Arg Gln Gly Arg Thr Leu Tyr Gly Phe Gly 
1               5                   10              


<210> 143  
<211> 8
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Sarcosine

<400> 143  
Xaa Arg Val Tyr Val His Pro Ala 
1               5               


<210> 144  
<211> 60
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polypeptide"  

<400> 144  
Arg Lys Arg Gly Arg Gln Thr Tyr Thr Arg Tyr Gln Thr Leu Glu Leu 
1               5                   10                  15      


Glu Lys Glu Phe His Phe Asn Arg Tyr Leu Thr Arg Arg Arg Arg Ile 
            20                  25                  30          


Glu Ile Ala His Ala Leu Cys Leu Thr Glu Arg Gln Ile Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Glu Asn 
    50                  55                  60  


<210> 145  
<211> 38
<212> PRT
<213> Homo sapiens

<400> 145  
Arg Arg Arg Pro Arg Pro Pro Tyr Leu Pro Arg Pro Arg Pro Pro Pro 
1               5                   10                  15      


Phe Phe Pro Pro Arg Leu Pro Pro Arg Ile Pro Pro Gly Phe Pro Pro 
            20                  25                  30          


Arg Phe Pro Pro Arg Phe 
        35              


<210> 146  
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Alpha-Glu

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Alpha-Asp

<220>
<221> MOD_RES
<222> (7)..(7)
<223> S-(acetylamino)methyl-Cys

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Alpha-Glu

<220>
<221> MOD_RES
<222> (10)..(10)
<223> S-(acetylamino)methyl-Cys

<220>
<221> MOD_RES
<222> (12)..(12)
<223> S-(acetylamino)methyl-Cys

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Alpha-Glu

<400> 146  
Glu Trp Gln Thr Asp Asn Cys Glu Thr Cys Thr Cys Tyr Glu 
1               5                   10                  


<210> 147  
<211> 116
<212> PRT
<213> Homo sapiens

<400> 147  
Met Leu Ser Cys Arg Leu Gln Cys Ala Leu Ala Ala Leu Ser Ile Val 
1               5                   10                  15      


Leu Ala Leu Gly Cys Val Thr Gly Ala Pro Ser Asp Pro Arg Leu Arg 
            20                  25                  30          


Gln Phe Leu Gln Lys Ser Leu Ala Ala Ala Ala Gly Lys Gln Glu Leu 
        35                  40                  45              


Ala Lys Tyr Phe Leu Ala Glu Leu Leu Ser Glu Pro Asn Gln Thr Glu 
    50                  55                  60                  


Asn Asp Ala Leu Glu Pro Glu Asp Leu Ser Gln Ala Ala Glu Gln Asp 
65                  70                  75                  80  


Glu Met Arg Leu Glu Leu Gln Arg Ser Ala Asn Ser Asn Pro Ala Met 
                85                  90                  95      


Ala Pro Arg Glu Arg Lys Ala Gly Cys Lys Asn Phe Phe Trp Lys Thr 
            100                 105                 110         


Phe Thr Ser Cys 
        115     


<210> 148  
<211> 176
<212> PRT
<213> Homo sapiens

<400> 148  
Met Gln Arg Arg Leu Val Gln Gln Trp Ser Val Ala Val Phe Leu Leu 
1               5                   10                  15      


Ser Tyr Ala Val Pro Ser Cys Gly Arg Ser Val Glu Gly Leu Ser Arg 
            20                  25                  30          


Arg Leu Lys Arg Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly 
        35                  40                  45              


Lys Ser Ile Gln Asp Leu Arg Arg Arg Phe Phe Leu His His Leu Ile 
    50                  55                  60                  


Ala Glu Ile His Thr Ala Glu Ile Arg Ala Thr Ser Glu Val Ser Pro 
65                  70                  75                  80  


Asn Ser Lys Pro Ser Pro Asn Thr Lys Asn His Pro Val Phe Gly Ser 
                85                  90                  95      


Asp Asp Glu Gly Arg Tyr Leu Thr Gln Glu Thr Asn Lys Val Glu Thr 
            100                 105                 110         


Tyr Lys Glu Gln Pro Leu Lys Thr Pro Gly Lys Lys Lys Lys Gly Lys 
        115                 120                 125             


Pro Gly Lys Arg Lys Glu Gln Glu Lys Lys Lys Arg Arg Thr Arg Ser 
    130                 135                 140                 


Ala Trp Leu Asp Ser Gly Val Thr Gly Ser Gly Leu Glu Gly Asp His 
145                 150                 155                 160 


Leu Ser Asp Thr Ser Thr Thr Ser Leu Glu Leu Asp Ser Arg Arg His 
                165                 170                 175     


<210> 149  
<211> 34
<212> PRT
<213> Homo sapiens

<400> 149  
Ser Val Ser Glu Ile Gln Leu Met His Asn Leu Gly Lys His Leu Asn 
1               5                   10                  15      


Ser Met Glu Arg Val Glu Trp Leu Arg Lys Lys Leu Gln Asp Val His 
            20                  25                  30          


Asn Phe 
        


<210> 150  
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polypeptide"  


<220>
<221> misc_feature
<222> (1)..(1)
<223> /note="N-term acetlyated"

<220>
<221> MOD_RES
<222> (10)..(11)
<223> Alpha-Glu

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Alpha-Glu

<220>
<221> MOD_RES
<222> (20)..(20)
<223> Alpha-Glu

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Alpha-Glu

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Alpha-Glu

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Alpha-Asp

<400> 150  
Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln 
1               5                   10                  15      


Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu 
            20                  25                  30          


Trp Asn Trp 
        35  


<210> 151  
<211> 5
<212> PRT
<213> Homo sapiens

<400> 151  
Ala Arg Pro Ala Lys 
1               5   


<210> 152  
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polypeptide"  

<400> 152  
Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val His Ser Ser Asn Asn Phe Gly Ala Ile Leu Ser Ser Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210> 153  
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polypeptide"  


<220>
<221> misc_feature
<222> (1)..(1)
<223> /note="N-term acetylated"

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Alpha-Asp

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Alpha-Glu

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Norleu

<220>
<221> MOD_RES
<222> (25)..(25)
<223> Alpha-Asp

<400> 153  
His Ser Asp Ala Val Phe Thr Glu Asn Tyr Thr Lys Leu Arg Lys Gln 
1               5                   10                  15      


Leu Ala Ala Lys Lys Tyr Leu Asn Asp Leu Lys Lys Gly Gly 
            20                  25                  30  


<210> 154  
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 154  
Leu Lys Arg Met Pro 
1               5   


<210> 155  
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Pyro-Glu

<400> 155  
Glu Glu Asp Cys Lys 
1               5   


<210> 156  
<211> 43
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polypeptide"  


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Alpha-Glu

<220>
<221> MOD_RES
<222> (13)..(13)
<223> Alpha-Glu

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Alpha-Glu

<400> 156  
Met Phe Leu Glu Ala Ile Pro Met Ser Ile Pro Pro Glu Val Lys Phe 
1               5                   10                  15      


Asn Lys Pro Phe Val Phe Leu Met Ile Glu Gln Asn Thr Lys Ser Pro 
            20                  25                  30          


Leu Phe Met Gly Lys Val Val Asn Pro Thr Gln 
        35                  40              


<210> 157  
<211> 7
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Isoval

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Norleu

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Statin residue

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Statin residue

<400> 157  
Val Phe Leu Xaa Ala Xaa Lys 
1               5           


<210> 158  
<211> 32
<212> PRT
<213> Salmo salar

<400> 158  
Cys Ser Asn Leu Ser Thr Cys Val Leu Gly Lys Leu Ser Gln Glu Leu 
1               5                   10                  15      


His Lys Leu Gln Thr Tyr Pro Arg Thr Asn Thr Gly Ser Gly Thr Pro 
            20                  25                  30          


<210> 159  
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> misc_feature
<222> (29)..(29)
<223> /note="C-term amidated"

<400> 159  
Tyr Ala Asp Ala Ile Phe Thr Asn Ser Tyr Arg Lys Val Leu Gly Gln 
1               5                   10                  15      


Leu Ser Ala Arg Lys Leu Leu Gln Asp Ile Met Ser Arg 
            20                  25                  


<210> 160  
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 160  
His Ser Asp Gly Thr Phe 
1               5       


<210> 161  
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 161  
Lys Leu Leu Leu Leu Lys Leu Leu Leu Leu Lys Leu Leu Leu Leu Lys 
1               5                   10                  15      


Leu Leu Leu Leu 
            20  


<210> 162  
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 162  
Trp Ala Gly Gly Asp Ala Ser Gly Glu 
1               5                   


<210> 163  
<211> 108
<212> PRT
<213> Homo sapiens

<400> 163  
Met Pro Leu Trp Val Phe Phe Phe Val Ile Leu Thr Leu Ser Asn Ser 
1               5                   10                  15      


Ser His Cys Ser Pro Pro Pro Pro Leu Thr Leu Arg Met Arg Arg Tyr 
            20                  25                  30          


Ala Asp Ala Ile Phe Thr Asn Ser Tyr Arg Lys Val Leu Gly Gln Leu 
        35                  40                  45              


Ser Ala Arg Lys Leu Leu Gln Asp Ile Met Ser Arg Gln Gln Gly Glu 
    50                  55                  60                  


Ser Asn Gln Glu Arg Gly Ala Arg Ala Arg Leu Gly Arg Gln Val Asp 
65                  70                  75                  80  


Ser Met Trp Ala Glu Gln Lys Gln Met Glu Leu Glu Ser Ile Leu Val 
                85                  90                  95      


Ala Leu Leu Gln Lys His Ser Arg Asn Ser Gln Gly 
            100                 105             


<210> 164  
<211> 70
<212> PRT
<213> Homo sapiens

<400> 164  
Met Pro Leu Trp Val Phe Phe Phe Val Ile Leu Thr Leu Ser Asn Ser 
1               5                   10                  15      


Ser His Cys Ser Pro Pro Pro Pro Leu Thr Leu Arg Met Arg Arg Tyr 
            20                  25                  30          


Ala Asp Ala Ile Phe Thr Asn Ser Tyr Arg Lys Val Leu Gly Gln Leu 
        35                  40                  45              


Ser Ala Arg Lys Leu Leu Gln Asp Ile Met Ser Arg Gln Gln Gly Glu 
    50                  55                  60                  


Ser Asn Gln Glu Arg Gly 
65                  70  


<210> 165  
<211> 38
<212> PRT
<213> Homo sapiens

<400> 165  
Ala Arg Ala Arg Leu Gly Arg Gln Val Asp Ser Met Trp Ala Glu Gln 
1               5                   10                  15      


Lys Gln Met Glu Leu Glu Ser Ile Leu Val Ala Leu Leu Gln Lys His 
            20                  25                  30          


Ser Arg Asn Ser Gln Gly 
        35              


<210> 166  
<211> 200
<212> PRT
<213> Homo sapiens

<400> 166  
Met Ala Ser Leu Tyr Val Gly Asp Leu His Pro Glu Val Thr Glu Ala 
1               5                   10                  15      


Met Leu Tyr Glu Lys Phe Ser Pro Ala Gly Pro Ile Leu Ser Ile Arg 
            20                  25                  30          


Ile Cys Arg Asp Lys Ile Thr Arg Arg Ser Leu Gly Tyr Ala Tyr Val 
        35                  40                  45              


Asn Tyr Gln Gln Pro Val Asp Ala Lys Arg Ala Leu Glu Thr Leu Asn 
    50                  55                  60                  


Phe Asp Val Ile Lys Gly Arg Pro Val Arg Ile Met Trp Ser Gln Arg 
65                  70                  75                  80  


Asp Pro Ser Leu Arg Lys Ser Gly Val Gly Asn Val Phe Ile Lys Asn 
                85                  90                  95      


Leu Gly Lys Thr Ile Asp Asn Lys Ala Leu Tyr Asn Ile Phe Ser Ala 
            100                 105                 110         


Phe Gly Asn Ile Leu Ser Cys Lys Val Ala Cys Asp Glu Lys Gly Pro 
        115                 120                 125             


Lys Gly Tyr Gly Phe Val His Phe Gln Lys Gln Glu Ser Ala Glu Arg 
    130                 135                 140                 


Ala Ile Asp Val Met Asn Gly Met Phe Leu Asn Tyr Arg Lys Ile Phe 
145                 150                 155                 160 


Val Gly Arg Phe Lys Ser His Lys Glu Arg Glu Ala Glu Arg Gly Ala 
                165                 170                 175     


Trp Ala Arg Gln Ser Thr Ser Ala Asp Val Lys Asp Phe Glu Glu Asp 
            180                 185                 190         


Thr Asp Glu Glu Ala Thr Leu Arg 
        195                 200 


<210> 167  
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 167  
Arg Arg Trp Cys Tyr Arg Lys Cys Tyr Lys Gly Tyr Cys Tyr Arg Lys 
1               5                   10                  15      


Cys 
    


<210> 168  
<211> 8
<212> PRT
<213> Homo sapiens

<400> 168  
Leu Glu Asp Gly Pro Lys Phe Leu 
1               5               


<210> 169  
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polypeptide"  

<400> 169  
Lys Ser Ser Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr 
1               5                   10                  15      


Glu Ala Ala Ala Phe Leu Pro Ser Asp Phe Phe Pro Ser Val 
            20                  25                  30  


<210> 170  
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Alpha-Asp

<220>
<221> MOD_RES
<222> (7)..(7)
<223> O-methyl-Tyr

<400> 170  
Cys Asn Pro Arg Gly Asp Tyr Arg 
1               5               


<210> 171  
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 171  
Gly Gly Gly Lys 
1               


<210> 172  
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> misc_feature
<222> (12)..(12)
<223> /note="C-term amidated"

<400> 172  
Gly Gly Gly Cys Tyr Phe Gln Asn Cys Pro Lys Gly 
1               5                   10          


<210> 173  
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 173  
Gln Glu Asp Leu Ile Asp Val 
1               5           


<210> 174  
<211> 214
<212> PRT
<213> Mus musculus

<400> 174  
Met Glu Pro Gly Leu Trp Leu Leu Leu Gly Leu Thr Val Thr Ser Ala 
1               5                   10                  15      


Ala Gly Leu Val Pro Cys Pro Gln Ser Gly Asp Ser Gly Arg Ala Ser 
            20                  25                  30          


Val Ser Gln Gly Pro Pro Glu Ala Gly Ser Glu Arg Gly Cys Glu Glu 
        35                  40                  45              


Thr Val Ala Gly Pro Gly Glu Arg Ile Val Ser Pro Thr Val Ala Leu 
    50                  55                  60                  


Pro Ala Gln Pro Glu Ser Ala Gly Gln Glu Arg Ala Pro Gly Arg Ser 
65                  70                  75                  80  


Gly Lys Gln Glu Asp Lys Gly Leu Pro Ala His His Arg Pro Arg Arg 
                85                  90                  95      


Cys Thr Cys Phe Thr Tyr Lys Asp Lys Glu Cys Val Tyr Tyr Cys His 
            100                 105                 110         


Leu Asp Ile Ile Trp Ile Asn Thr Pro Glu Gln Thr Val Pro Tyr Gly 
        115                 120                 125             


Leu Ser Asn Tyr Arg Glu Ser Leu Arg Gly Lys Arg Ser Leu Gly Pro 
    130                 135                 140                 


Val Pro Glu Ser Ser Gln Pro Ser Pro Trp Thr Arg Leu Arg Cys Thr 
145                 150                 155                 160 


Cys Met Gly Ala Asp Asp Lys Ala Cys Ala His Phe Cys Ala Arg Thr 
                165                 170                 175     


Arg Asp Val Thr Ser Tyr Ser Gly Arg Ala Glu Arg Pro Ala Ala Glu 
            180                 185                 190         


Glu Met Arg Glu Thr Gly Gly Pro Arg Gln Arg Leu Met Ser Arg Thr 
        195                 200                 205             


Asp Lys Ala His Arg Pro 
    210                 


<210> 175  
<211> 356
<212> PRT
<213> Homo sapiens

<400> 175  
Met Ala Ala Glu Gly Trp Ile Trp Arg Trp Gly Trp Gly Arg Arg Cys 
1               5                   10                  15      


Leu Gly Arg Pro Gly Leu Leu Gly Pro Gly Pro Gly Pro Thr Thr Pro 
            20                  25                  30          


Leu Phe Leu Leu Leu Leu Leu Gly Ser Val Thr Ala Asp Ile Thr Asp 
        35                  40                  45              


Gly Asn Ser Glu His Leu Lys Arg Glu His Ser Leu Ile Lys Pro Tyr 
    50                  55                  60                  


Gln Gly Val Gly Ser Ser Ser Met Pro Leu Trp Asp Phe Gln Gly Ser 
65                  70                  75                  80  


Thr Met Leu Thr Ser Gln Tyr Val Arg Leu Thr Pro Asp Glu Arg Ser 
                85                  90                  95      


Lys Glu Gly Ser Ile Trp Asn His Gln Pro Cys Phe Leu Lys Asp Trp 
            100                 105                 110         


Glu Met His Val His Phe Lys Val His Gly Thr Gly Lys Lys Asn Leu 
        115                 120                 125             


His Gly Asp Gly Ile Ala Leu Trp Tyr Thr Arg Asp Arg Leu Val Pro 
    130                 135                 140                 


Gly Pro Val Phe Gly Ser Lys Asp Asn Phe His Gly Leu Ala Ile Phe 
145                 150                 155                 160 


Leu Asp Thr Tyr Pro Asn Asp Glu Thr Thr Glu Arg Val Phe Pro Tyr 
                165                 170                 175     


Ile Ser Val Met Val Asn Asn Gly Ser Leu Ser Tyr Asp His Ser Lys 
            180                 185                 190         


Asp Gly Arg Trp Thr Glu Leu Ala Gly Cys Thr Ala Asp Phe Arg Asn 
        195                 200                 205             


Arg Asp His Asp Thr Phe Leu Ala Val Arg Tyr Ser Arg Gly Arg Leu 
    210                 215                 220                 


Thr Val Met Thr Asp Leu Glu Asp Lys Asn Glu Trp Lys Asn Cys Ile 
225                 230                 235                 240 


Asp Ile Thr Gly Val Arg Leu Pro Thr Gly Tyr Tyr Phe Gly Ala Ser 
                245                 250                 255     


Ala Gly Thr Gly Asp Leu Ser Asp Asn His Asp Ile Ile Ser Met Lys 
            260                 265                 270         


Leu Phe Gln Leu Met Val Glu His Thr Pro Asp Glu Glu Ser Ile Asp 
        275                 280                 285             


Trp Thr Lys Ile Glu Pro Ser Val Asn Phe Leu Lys Ser Pro Lys Asp 
    290                 295                 300                 


Asn Val Asp Asp Pro Thr Gly Asn Phe Arg Ser Gly Pro Leu Thr Gly 
305                 310                 315                 320 


Trp Arg Val Phe Leu Leu Leu Leu Cys Ala Leu Leu Gly Ile Val Val 
                325                 330                 335     


Cys Ala Val Val Gly Ala Val Val Phe Gln Lys Arg Gln Glu Arg Asn 
            340                 345                 350         


Lys Arg Phe Tyr 
        355     


<210> 176  
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> misc_feature
<222> (8)..(8)
<223> /note="C-term amidated"

<400> 176  
Thr Asp Ser Phe Val Gly Leu Met 
1               5               


<210> 177  
<211> 8
<212> PRT
<213> Homo sapiens

<400> 177  
Lys Pro Gly Glu Pro Gly Pro Lys 
1               5               


<210> 178  
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 178  
Gly Ser His Lys 
1               


<210> 179  
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 179  
Ala Ser His Lys 
1               


<210> 180  
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 180  
Leu Ser His Lys 
1               


<210> 181  
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 181  
Thr Ser His Lys 
1               


<210> 182  
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 182  
Tyr Ser His Lys 
1               


<210> 183  
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 183  
Pro Ser His Lys 
1               


<210> 184  
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Pyro-Glu

<400> 184  
Glu Ser His Lys 
1               


<210> 185  
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 185  
Trp Ser His Lys 
1               


<210> 186  
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Hydroxy-Pro

<400> 186  
Pro Pro Gly Ala Gly 
1               5   


<210> 187  
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 187  
Trp Ala Ser Gly Asn 
1               5   


<210> 188  
<211> 8
<212> PRT
<213> Homo sapiens

<400> 188  
Asp Ala Asp Pro Arg Gln Tyr Ala 
1               5               


<210> 189  
<211> 518
<212> PRT
<213> Homo sapiens

<400> 189  
Met Ser Cys Val Lys Leu Trp Pro Ser Gly Ala Pro Ala Pro Leu Val 
1               5                   10                  15      


Ser Ile Glu Glu Leu Glu Asn Gln Glu Leu Val Gly Lys Gly Gly Phe 
            20                  25                  30          


Gly Thr Val Phe Arg Ala Gln His Arg Lys Trp Gly Tyr Asp Val Ala 
        35                  40                  45              


Val Lys Ile Val Asn Ser Lys Ala Ile Ser Arg Glu Val Lys Ala Met 
    50                  55                  60                  


Ala Ser Leu Asp Asn Glu Phe Val Leu Arg Leu Glu Gly Val Ile Glu 
65                  70                  75                  80  


Lys Val Asn Trp Asp Gln Asp Pro Lys Pro Ala Leu Val Thr Lys Phe 
                85                  90                  95      


Met Glu Asn Gly Ser Leu Ser Gly Leu Leu Gln Ser Gln Cys Pro Arg 
            100                 105                 110         


Pro Trp Pro Leu Leu Cys Arg Leu Leu Lys Glu Val Val Leu Gly Met 
        115                 120                 125             


Phe Tyr Leu His Asp Gln Asn Pro Val Leu Leu His Arg Asp Leu Lys 
    130                 135                 140                 


Pro Ser Asn Val Leu Leu Asp Pro Glu Leu His Val Lys Leu Ala Asp 
145                 150                 155                 160 


Phe Gly Leu Ser Thr Phe Gln Gly Gly Ser Gln Ser Gly Thr Gly Ser 
                165                 170                 175     


Gly Glu Pro Gly Gly Thr Leu Gly Tyr Leu Ala Pro Glu Leu Phe Val 
            180                 185                 190         


Asn Val Asn Arg Lys Ala Ser Thr Ala Ser Asp Val Tyr Ser Phe Gly 
        195                 200                 205             


Ile Leu Met Trp Ala Val Leu Ala Gly Arg Glu Val Glu Leu Pro Thr 
    210                 215                 220                 


Glu Pro Ser Leu Val Tyr Glu Ala Val Cys Asn Arg Gln Asn Arg Pro 
225                 230                 235                 240 


Ser Leu Ala Glu Leu Pro Gln Ala Gly Pro Glu Thr Pro Gly Leu Glu 
                245                 250                 255     


Gly Leu Lys Glu Leu Met Gln Leu Cys Trp Ser Ser Glu Pro Lys Asp 
            260                 265                 270         


Arg Pro Ser Phe Gln Glu Cys Leu Pro Lys Thr Asp Glu Val Phe Gln 
        275                 280                 285             


Met Val Glu Asn Asn Met Asn Ala Ala Val Ser Thr Val Lys Asp Phe 
    290                 295                 300                 


Leu Ser Gln Leu Arg Ser Ser Asn Arg Arg Phe Ser Ile Pro Glu Ser 
305                 310                 315                 320 


Gly Gln Gly Gly Thr Glu Met Asp Gly Phe Arg Arg Thr Ile Glu Asn 
                325                 330                 335     


Gln His Ser Arg Asn Asp Val Met Val Ser Glu Trp Leu Asn Lys Leu 
            340                 345                 350         


Asn Leu Glu Glu Pro Pro Ser Ser Val Pro Lys Lys Cys Pro Ser Leu 
        355                 360                 365             


Thr Lys Arg Ser Arg Ala Gln Glu Glu Gln Val Pro Gln Ala Trp Thr 
    370                 375                 380                 


Ala Gly Thr Ser Ser Asp Ser Met Ala Gln Pro Pro Gln Thr Pro Glu 
385                 390                 395                 400 


Thr Ser Thr Phe Arg Asn Gln Met Pro Ser Pro Thr Ser Thr Gly Thr 
                405                 410                 415     


Pro Ser Pro Gly Pro Arg Gly Asn Gln Gly Ala Glu Arg Gln Gly Met 
            420                 425                 430         


Asn Trp Ser Cys Arg Thr Pro Glu Pro Asn Pro Val Thr Gly Arg Pro 
        435                 440                 445             


Leu Val Asn Ile Tyr Asn Cys Ser Gly Val Gln Val Gly Asp Asn Asn 
    450                 455                 460                 


Tyr Leu Thr Met Gln Gln Thr Thr Ala Leu Pro Thr Trp Gly Leu Ala 
465                 470                 475                 480 


Pro Ser Gly Lys Gly Arg Gly Leu Gln His Pro Pro Pro Val Gly Ser 
                485                 490                 495     


Gln Glu Gly Pro Lys Asp Pro Glu Ala Trp Ser Arg Pro Gln Gly Trp 
            500                 505                 510         


Tyr Asn His Ser Gly Lys 
        515             


<210> 190  
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 190  
Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Glu Glu 
1               5                   10                  15      


Trp Ile Gly 
            


<210> 191  
<211> 82
<212> PRT
<213> Homo sapiens

<400> 191  
Gly Ser Gly Leu Thr Asn Ile Lys Thr Glu Glu Ile Ser Glu Val Lys 
1               5                   10                  15      


Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln 
            20                  25                  30          


Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile 
        35                  40                  45              


Ile Gly Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Ile Ile 
    50                  55                  60                  


Thr Leu Val Met Leu Lys Lys Gln Tyr Thr Ser Asn His His Gly Val 
65                  70                  75                  80  


Val Glu 
        


<210> 192  
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> misc_feature
<222> (10)..(10)
<223> /note="C-term amidated"

<400> 192  
Leu Arg Ala His Ala Val Asp Val Asn Gly 
1               5                   10  


<210> 193  
<211> 9
<212> PRT
<213> Homo sapiens

<400> 193  
Leu Leu Pro Gly Gly Arg Pro Tyr Arg 
1               5                   


<210> 194  
<211> 359
<212> PRT
<213> Homo sapiens

<400> 194  
Met Ile Leu Asn Ser Ser Thr Glu Asp Gly Ile Lys Arg Ile Gln Asp 
1               5                   10                  15      


Asp Cys Pro Lys Ala Gly Arg His Asn Tyr Ile Phe Val Met Ile Pro 
            20                  25                  30          


Thr Leu Tyr Ser Ile Ile Phe Val Val Gly Ile Phe Gly Asn Ser Leu 
        35                  40                  45              


Val Val Ile Val Ile Tyr Phe Tyr Met Lys Leu Lys Thr Val Ala Ser 
    50                  55                  60                  


Val Phe Leu Leu Asn Leu Ala Leu Ala Asp Leu Cys Phe Leu Leu Thr 
65                  70                  75                  80  


Leu Pro Leu Trp Ala Val Tyr Thr Ala Met Glu Tyr Arg Trp Pro Phe 
                85                  90                  95      


Gly Asn Tyr Leu Cys Lys Ile Ala Ser Ala Ser Val Ser Phe Asn Leu 
            100                 105                 110         


Tyr Ala Ser Val Phe Leu Leu Thr Cys Leu Ser Ile Asp Arg Tyr Leu 
        115                 120                 125             


Ala Ile Val His Pro Met Lys Ser Arg Leu Arg Arg Thr Met Leu Val 
    130                 135                 140                 


Ala Lys Val Thr Cys Ile Ile Ile Trp Leu Leu Ala Gly Leu Ala Ser 
145                 150                 155                 160 


Leu Pro Ala Ile Ile His Arg Asn Val Phe Phe Ile Glu Asn Thr Asn 
                165                 170                 175     


Ile Thr Val Cys Ala Phe His Tyr Glu Ser Gln Asn Ser Thr Leu Pro 
            180                 185                 190         


Ile Gly Leu Gly Leu Thr Lys Asn Ile Leu Gly Phe Leu Phe Pro Phe 
        195                 200                 205             


Leu Ile Ile Leu Thr Ser Tyr Thr Leu Ile Trp Lys Ala Leu Lys Lys 
    210                 215                 220                 


Ala Tyr Glu Ile Gln Lys Asn Lys Pro Arg Asn Asp Asp Ile Phe Lys 
225                 230                 235                 240 


Ile Ile Met Ala Ile Val Leu Phe Phe Phe Phe Ser Trp Ile Pro His 
                245                 250                 255     


Gln Ile Phe Thr Phe Leu Asp Val Leu Ile Gln Leu Gly Ile Ile Arg 
            260                 265                 270         


Asp Cys Arg Ile Ala Asp Ile Val Asp Thr Ala Met Pro Ile Thr Ile 
        275                 280                 285             


Cys Ile Ala Tyr Phe Asn Asn Cys Leu Asn Pro Leu Phe Tyr Gly Phe 
    290                 295                 300                 


Leu Gly Lys Lys Phe Lys Arg Tyr Phe Leu Gln Leu Leu Lys Tyr Ile 
305                 310                 315                 320 


Pro Pro Lys Ala Lys Ser His Ser Asn Leu Ser Thr Lys Met Ser Thr 
                325                 330                 335     


Leu Ser Tyr Arg Pro Ser Asp Asn Val Ser Ser Ser Thr Lys Lys Pro 
            340                 345                 350         


Ala Pro Cys Phe Glu Val Glu 
        355                 


<210> 195  
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 195  
Ile Leu Arg Trp Pro Trp Trp Pro Trp Arg Arg 
1               5                   10      


<210> 196  
<211> 109
<212> PRT
<213> Homo sapiens

<400> 196  
Met Arg Gly Ala Leu Leu Val Leu Ala Leu Leu Val Thr Gln Ala Leu 
1               5                   10                  15      


Gly Val Lys Met Ala Glu Thr Cys Pro Ile Phe Tyr Asp Val Phe Phe 
            20                  25                  30          


Ala Val Ala Asn Gly Asn Glu Leu Leu Leu Asp Leu Ser Leu Thr Lys 
        35                  40                  45              


Val Asn Ala Thr Glu Pro Glu Arg Thr Ala Met Lys Lys Ile Gln Asp 
    50                  55                  60                  


Cys Tyr Val Glu Asn Gly Leu Ile Ser Arg Val Leu Asp Gly Leu Val 
65                  70                  75                  80  


Met Thr Thr Ile Ser Ser Ser Lys Asp Cys Met Gly Glu Ala Val Gln 
                85                  90                  95      


Asn Thr Val Glu Asp Leu Lys Leu Asn Thr Leu Gly Arg 
            100                 105                 


<210> 197  
<211> 138
<212> PRT
<213> Homo sapiens

<400> 197  
Met Asn Ser Leu Val Ser Trp Gln Leu Leu Leu Phe Leu Cys Ala Thr 
1               5                   10                  15      


His Phe Gly Glu Pro Leu Glu Lys Val Ala Ser Val Gly Asn Ser Arg 
            20                  25                  30          


Pro Thr Gly Gln Gln Leu Glu Ser Leu Gly Leu Leu Ala Pro Gly Glu 
        35                  40                  45              


Gln Ser Leu Pro Cys Thr Glu Arg Lys Pro Ala Ala Thr Ala Arg Leu 
    50                  55                  60                  


Ser Arg Arg Gly Thr Ser Leu Ser Pro Pro Pro Glu Ser Ser Gly Ser 
65                  70                  75                  80  


Pro Gln Gln Pro Gly Leu Ser Ala Pro His Ser Arg Gln Ile Pro Ala 
                85                  90                  95      


Pro Gln Gly Ala Val Leu Val Gln Arg Glu Lys Asp Leu Pro Asn Tyr 
            100                 105                 110         


Asn Trp Asn Ser Phe Gly Leu Arg Phe Gly Lys Arg Glu Ala Ala Pro 
        115                 120                 125             


Gly Asn His Gly Arg Ser Ala Gly Arg Gly 
    130                 135             


<210> 198  
<211> 422
<212> PRT
<213> Homo sapiens

<400> 198  
Met Ser Thr Ser Tyr Gly Cys Phe Trp Arg Arg Phe Ile His Gly Ile 
1               5                   10                  15      


Gly Arg Ser Gly Asp Ile Ser Ala Val Gln Pro Lys Ala Ala Gly Ser 
            20                  25                  30          


Ser Leu Leu Asn Lys Ile Thr Asn Ser Leu Val Leu Asp Ile Ile Lys 
        35                  40                  45              


Leu Ala Gly Val His Thr Val Ala Asn Cys Phe Val Val Pro Met Ala 
    50                  55                  60                  


Thr Gly Met Ser Leu Thr Leu Cys Phe Leu Thr Leu Arg His Lys Arg 
65                  70                  75                  80  


Pro Lys Ala Lys Tyr Ile Ile Trp Pro Arg Ile Asp Gln Lys Ser Cys 
                85                  90                  95      


Phe Lys Ser Met Ile Thr Ala Gly Phe Glu Pro Val Val Ile Glu Asn 
            100                 105                 110         


Val Leu Glu Gly Asp Glu Leu Arg Thr Asp Leu Lys Ala Val Glu Ala 
        115                 120                 125             


Lys Val Gln Glu Leu Gly Pro Asp Cys Ile Leu Cys Ile His Ser Thr 
    130                 135                 140                 


Thr Ser Cys Phe Ala Pro Arg Val Pro Asp Arg Leu Glu Glu Leu Ala 
145                 150                 155                 160 


Val Ile Cys Ala Asn Tyr Asp Ile Pro His Ile Val Asn Asn Ala Tyr 
                165                 170                 175     


Gly Val Gln Ser Ser Lys Cys Met His Leu Ile Gln Gln Gly Ala Arg 
            180                 185                 190         


Val Gly Arg Ile Asp Ala Phe Val Gln Ser Leu Asp Lys Asn Phe Met 
        195                 200                 205             


Val Pro Val Gly Gly Ala Ile Ile Ala Gly Phe Asn Asp Ser Phe Ile 
    210                 215                 220                 


Gln Glu Ile Ser Lys Met Tyr Pro Gly Arg Ala Ser Ala Ser Pro Ser 
225                 230                 235                 240 


Leu Asp Val Leu Ile Thr Leu Leu Ser Leu Gly Ser Asn Gly Tyr Lys 
                245                 250                 255     


Lys Leu Leu Lys Glu Arg Lys Glu Met Phe Ser Tyr Leu Ser Asn Gln 
            260                 265                 270         


Ile Lys Lys Leu Ser Glu Ala Tyr Asn Glu Arg Leu Leu His Thr Pro 
        275                 280                 285             


His Asn Pro Ile Ser Leu Ala Met Thr Leu Lys Thr Leu Asp Glu His 
    290                 295                 300                 


Arg Asp Lys Ala Val Thr Gln Leu Gly Ser Met Leu Phe Thr Lys Gln 
305                 310                 315                 320 


Val Ser Gly Ala Arg Val Val Pro Leu Gly Ser Met Gln Thr Val Ser 
                325                 330                 335     


Gly Tyr Thr Phe Arg Gly Phe Met Ser His Thr Asn Asn Tyr Pro Cys 
            340                 345                 350         


Ala Tyr Leu Asn Ala Ala Ser Ala Ile Gly Met Lys Met Gln Asp Val 
        355                 360                 365             


Asp Leu Phe Ile Asn Arg Leu Asp Arg Cys Leu Lys Ala Val Arg Lys 
    370                 375                 380                 


Glu Arg Ser Lys Glu Ser Asp Asp Asn Tyr Asp Lys Thr Glu Asp Val 
385                 390                 395                 400 


Asp Ile Glu Glu Met Ala Leu Lys Leu Asp Asn Val Leu Leu Asp Thr 
                405                 410                 415     


Tyr Gln Asp Ala Ser Ser 
            420         


<210> 199  
<211> 246
<212> PRT
<213> Homo sapiens

<400> 199  
Met Thr Leu Ile Glu Gly Val Gly Asp Glu Val Thr Val Leu Phe Ser 
1               5                   10                  15      


Val Leu Ala Cys Leu Leu Val Leu Ala Leu Ala Trp Val Ser Thr His 
            20                  25                  30          


Thr Ala Glu Gly Gly Asp Pro Leu Pro Gln Pro Ser Gly Thr Pro Thr 
        35                  40                  45              


Pro Ser Gln Pro Ser Ala Ala Met Ala Ala Thr Asp Ser Met Arg Gly 
    50                  55                  60                  


Glu Ala Pro Gly Ala Glu Thr Pro Ser Leu Arg His Arg Gly Gln Ala 
65                  70                  75                  80  


Ala Gln Pro Glu Pro Ser Thr Gly Phe Thr Ala Thr Pro Pro Ala Pro 
                85                  90                  95      


Asp Ser Pro Gln Glu Pro Leu Val Leu Arg Leu Lys Phe Leu Asn Asp 
            100                 105                 110         


Ser Glu Gln Val Ala Arg Ala Trp Pro His Asp Thr Ile Gly Ser Leu 
        115                 120                 125             


Lys Arg Thr Gln Phe Pro Gly Arg Glu Gln Gln Val Arg Leu Ile Tyr 
    130                 135                 140                 


Gln Gly Gln Leu Leu Gly Asp Asp Thr Gln Thr Leu Gly Ser Leu His 
145                 150                 155                 160 


Leu Pro Pro Asn Cys Val Leu His Cys His Val Ser Thr Arg Val Gly 
                165                 170                 175     


Pro Pro Asn Pro Pro Cys Pro Pro Gly Ser Glu Pro Gly Pro Ser Gly 
            180                 185                 190         


Leu Glu Ile Gly Ser Leu Leu Leu Pro Leu Leu Leu Leu Leu Leu Leu 
        195                 200                 205             


Leu Leu Trp Tyr Cys Gln Ile Gln Tyr Arg Pro Phe Phe Pro Leu Thr 
    210                 215                 220                 


Ala Thr Leu Gly Leu Ala Gly Phe Thr Leu Leu Leu Ser Leu Leu Ala 
225                 230                 235                 240 


Phe Ala Met Tyr Arg Pro 
                245     


<210> 200  
<211> 39
<212> PRT
<213> Homo sapiens


<220>
<221> misc_feature
<222> (39)..(39)
<223> /note="C-term amidated"

<400> 200  
His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser
        35              


<210> 201  
<211> 177
<212> PRT
<213> Homo sapiens

<400> 201  
Met Gln Arg Arg Leu Val Gln Gln Trp Ser Val Ala Val Phe Leu Leu 
1               5                   10                  15      


Ser Tyr Ala Val Pro Ser Cys Gly Arg Ser Val Glu Gly Leu Ser Arg 
            20                  25                  30          


Arg Leu Lys Arg Ala Val Ser Glu His Gln Leu Leu His Asp Lys Gly 
        35                  40                  45              


Lys Ser Ile Gln Asp Leu Arg Arg Arg Phe Phe Leu His His Leu Ile 
    50                  55                  60                  


Ala Glu Ile His Thr Ala Glu Ile Arg Ala Thr Ser Glu Val Ser Pro 
65                  70                  75                  80  


Asn Ser Lys Pro Ser Pro Asn Thr Lys Asn His Pro Val Arg Phe Gly 
                85                  90                  95      


Ser Asp Asp Glu Gly Arg Tyr Leu Thr Gln Glu Thr Asn Lys Val Glu 
            100                 105                 110         


Thr Tyr Lys Glu Gln Pro Leu Lys Thr Pro Gly Lys Lys Lys Lys Gly 
        115                 120                 125             


Lys Pro Gly Lys Arg Lys Glu Gln Glu Lys Lys Lys Arg Arg Thr Arg 
    130                 135                 140                 


Ser Ala Trp Leu Asp Ser Gly Val Thr Gly Ser Gly Leu Glu Gly Asp 
145                 150                 155                 160 


His Leu Ser Asp Thr Ser Thr Thr Ser Leu Glu Leu Asp Ser Arg Arg 
                165                 170                 175     


His 
    


<210> 202  
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polypeptide"  


<220>
<221> misc_feature
<222> (36)..(36)
<223> /note="C-term amidated"

<400> 202  
Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Met Ala Arg Lys Cys 
1               5                   10                  15      


Asp Asp Cys Cys Gly Gly Lys Gly Arg Gly Lys Cys Tyr Gly Pro Gln 
            20                  25                  30          


Cys Leu Cys Arg 
        35      


<210> 203  
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> misc_feature
<222> (1)..(1)
<223> /note="N-term acetylated"

<220>
<221> misc_feature
<222> (12)..(12)
<223> /note="C-term amidated"

<400> 203  
Arg Tyr Tyr Arg Trp Lys Lys Lys Lys Lys Lys Lys 
1               5                   10          


<210> 204  
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 204  
Cys Thr Thr His Trp Gly Phe Thr Leu Cys 
1               5                   10  


<210> 205  
<211> 97
<212> PRT
<213> Homo sapiens

<400> 205  
Met Val Phe Val Arg Arg Pro Trp Pro Ala Leu Thr Thr Val Leu Leu 
1               5                   10                  15      


Ala Leu Leu Val Cys Leu Gly Ala Leu Val Asp Ala Tyr Pro Ile Lys 
            20                  25                  30          


Pro Glu Ala Pro Arg Glu Asp Ala Ser Pro Glu Glu Leu Asn Arg Tyr 
        35                  40                  45              


Tyr Ala Ser Leu Arg His Tyr Leu Asn Leu Val Thr Arg Gln Arg Tyr 
    50                  55                  60                  


Gly Lys Arg Asp Gly Pro Asp Thr Leu Leu Ser Lys Thr Phe Phe Pro 
65                  70                  75                  80  


Asp Gly Glu Asp Arg Pro Val Arg Ser Arg Ser Glu Gly Pro Asp Leu 
                85                  90                  95      


Trp 
    


<210> 206  
<211> 8
<212> PRT
<213> Homo sapiens

<400> 206  
Asn Ala Pro Val Ser Ile Pro Gln 
1               5               


<210> 207  
<211> 711
<212> PRT
<213> Homo sapiens

<400> 207  
Met Ala Glu Arg Glu Ser Gly Gly Leu Gly Gly Gly Ala Ala Ser Pro 
1               5                   10                  15      


Pro Ala Ala Ser Pro Phe Leu Gly Leu His Ile Ala Ser Pro Pro Asn 
            20                  25                  30          


Phe Arg Leu Thr His Asp Ile Ser Leu Glu Glu Phe Glu Asp Glu Asp 
        35                  40                  45              


Leu Ser Glu Ile Thr Asp Glu Cys Gly Ile Ser Leu Gln Cys Lys Asp 
    50                  55                  60                  


Thr Leu Ser Leu Arg Pro Pro Arg Ala Gly Leu Leu Ser Ala Gly Gly 
65                  70                  75                  80  


Gly Gly Ala Gly Ser Arg Leu Gln Ala Glu Met Leu Gln Met Asp Leu 
                85                  90                  95      


Ile Asp Ala Thr Gly Asp Thr Pro Gly Ala Glu Asp Asp Glu Glu Asp 
            100                 105                 110         


Asp Asp Glu Glu Arg Ala Ala Arg Arg Pro Gly Ala Gly Pro Pro Lys 
        115                 120                 125             


Ala Glu Ser Gly Gln Glu Pro Ala Ser Arg Gly Gln Gly Gln Ser Gln 
    130                 135                 140                 


Gly Gln Ser Gln Gly Pro Gly Ser Gly Asp Thr Tyr Arg Pro Lys Arg 
145                 150                 155                 160 


Pro Thr Thr Leu Asn Leu Phe Pro Gln Val Pro Arg Ser Gln Asp Thr 
                165                 170                 175     


Leu Asn Asn Asn Ser Leu Gly Lys Lys His Ser Trp Gln Asp Arg Val 
            180                 185                 190         


Ser Arg Ser Ser Ser Pro Leu Lys Thr Gly Glu Gln Thr Pro Pro His 
        195                 200                 205             


Glu His Ile Cys Leu Ser Asp Glu Leu Pro Pro Gln Ser Gly Pro Ala 
    210                 215                 220                 


Pro Thr Thr Asp Arg Gly Thr Ser Thr Asp Ser Pro Cys Arg Arg Ser 
225                 230                 235                 240 


Thr Ala Thr Gln Met Ala Pro Pro Gly Gly Pro Pro Ala Ala Pro Pro 
                245                 250                 255     


Gly Gly Arg Gly His Ser His Arg Asp Arg Ile His Tyr Gln Ala Asp 
            260                 265                 270         


Val Arg Leu Glu Ala Thr Glu Glu Ile Tyr Leu Thr Pro Val Gln Arg 
        275                 280                 285             


Pro Pro Asp Ala Ala Glu Pro Thr Ser Ala Phe Leu Pro Pro Thr Glu 
    290                 295                 300                 


Ser Arg Met Ser Val Ser Ser Asp Pro Asp Pro Ala Ala Tyr Pro Ser 
305                 310                 315                 320 


Thr Ala Gly Arg Pro His Pro Ser Ile Ser Glu Glu Glu Glu Gly Phe 
                325                 330                 335     


Asp Cys Leu Ser Ser Pro Glu Arg Ala Glu Pro Pro Gly Gly Gly Trp 
            340                 345                 350         


Arg Gly Ser Leu Gly Glu Pro Pro Pro Pro Pro Arg Ala Ser Leu Ser 
        355                 360                 365             


Ser Asp Thr Ser Ala Leu Ser Tyr Asp Ser Val Lys Tyr Thr Leu Val 
    370                 375                 380                 


Val Asp Glu His Ala Gln Leu Glu Leu Val Ser Leu Arg Pro Cys Phe 
385                 390                 395                 400 


Gly Asp Tyr Ser Asp Glu Ser Asp Ser Ala Thr Val Tyr Asp Asn Cys 
                405                 410                 415     


Ala Ser Val Ser Ser Pro Tyr Glu Ser Ala Ile Gly Glu Glu Tyr Glu 
            420                 425                 430         


Glu Ala Pro Arg Pro Gln Pro Pro Ala Cys Leu Ser Glu Asp Ser Thr 
        435                 440                 445             


Pro Asp Glu Pro Asp Val His Phe Ser Lys Lys Phe Leu Asn Val Phe 
    450                 455                 460                 


Met Ser Gly Arg Ser Arg Ser Ser Ser Ala Glu Ser Phe Gly Leu Phe 
465                 470                 475                 480 


Ser Cys Ile Ile Asn Gly Glu Glu Gln Glu Gln Thr His Arg Ala Ile 
                485                 490                 495     


Phe Arg Phe Val Pro Arg His Glu Asp Glu Leu Glu Leu Glu Val Asp 
            500                 505                 510         


Asp Pro Leu Leu Val Glu Leu Gln Ala Glu Asp Tyr Trp Tyr Glu Ala 
        515                 520                 525             


Tyr Asn Met Arg Thr Gly Ala Arg Gly Val Phe Pro Ala Tyr Tyr Ala 
    530                 535                 540                 


Ile Glu Val Thr Lys Glu Pro Glu His Met Ala Ala Leu Ala Lys Asn 
545                 550                 555                 560 


Ser Asp Trp Val Asp Gln Phe Arg Val Lys Phe Leu Gly Ser Val Gln 
                565                 570                 575     


Val Pro Tyr His Lys Gly Asn Asp Val Leu Cys Ala Ala Met Gln Lys 
            580                 585                 590         


Ile Ala Thr Thr Arg Arg Leu Thr Val His Phe Asn Pro Pro Ser Ser 
        595                 600                 605             


Cys Val Leu Glu Ile Ser Val Arg Gly Val Lys Ile Gly Val Lys Ala 
    610                 615                 620                 


Asp Asp Ser Gln Glu Ala Lys Gly Asn Lys Cys Ser His Phe Phe Gln 
625                 630                 635                 640 


Leu Lys Asn Ile Ser Phe Cys Gly Tyr His Pro Lys Asn Asn Lys Tyr 
                645                 650                 655     


Phe Gly Phe Ile Thr Lys His Pro Ala Asp His Arg Phe Ala Cys His 
            660                 665                 670         


Val Phe Val Ser Glu Asp Ser Thr Lys Ala Leu Ala Glu Ser Val Gly 
        675                 680                 685             


Arg Ala Phe Gln Gln Phe Tyr Lys Gln Phe Val Glu Tyr Thr Cys Pro 
    690                 695                 700                 


Thr Glu Asp Ile Tyr Leu Glu 
705                 710     


<210> 208  
<211> 710
<212> PRT
<213> Homo sapiens

<400> 208  
Met Ala Glu Arg Glu Ser Gly Gly Leu Gly Gly Gly Ala Ala Ser Pro 
1               5                   10                  15      


Pro Ala Ala Ser Pro Phe Leu Gly Leu His Ile Ala Ser Pro Pro Asn 
            20                  25                  30          


Phe Arg Leu Thr His Asp Ile Ser Leu Glu Glu Phe Glu Asp Glu Asp 
        35                  40                  45              


Leu Ser Glu Ile Thr Asp Glu Cys Gly Ile Ser Leu Gln Cys Lys Asp 
    50                  55                  60                  


Thr Leu Ser Leu Arg Pro Pro Arg Ala Gly Leu Leu Ser Ala Gly Gly 
65                  70                  75                  80  


Gly Gly Ala Gly Ser Arg Leu Gln Ala Glu Met Leu Gln Met Asp Leu 
                85                  90                  95      


Ile Asp Ala Thr Gly Asp Thr Pro Gly Ala Glu Asp Asp Glu Glu Asp 
            100                 105                 110         


Asp Asp Glu Glu Arg Ala Ala Arg Arg Pro Gly Ala Gly Pro Pro Lys 
        115                 120                 125             


Ala Glu Ser Gly Gln Glu Pro Ala Ser Arg Gly Gln Gly Gln Ser Gln 
    130                 135                 140                 


Gly Gln Ser Gln Gly Pro Gly Ser Gly Asp Thr Tyr Arg Pro Lys Arg 
145                 150                 155                 160 


Pro Thr Thr Leu Asn Leu Phe Pro Gln Val Pro Arg Ser Gln Asp Thr 
                165                 170                 175     


Leu Asn Asn Asn Ser Leu Gly Lys Lys His Ser Trp Gln Asp Arg Val 
            180                 185                 190         


Ser Arg Ser Ser Ser Pro Leu Lys Thr Gly Glu Gln Thr Pro Pro His 
        195                 200                 205             


Glu His Ile Cys Leu Ser Asp Glu Leu Pro Pro Gln Ser Gly Pro Ala 
    210                 215                 220                 


Pro Thr Thr Asp Arg Gly Thr Ser Thr Asp Ser Pro Cys Arg Arg Ser 
225                 230                 235                 240 


Thr Ala Thr Gln Met Ala Pro Pro Gly Gly Pro Pro Ala Ala Pro Pro 
                245                 250                 255     


Gly Gly Arg Gly His Ser His Arg Asp Arg Ile His Tyr Gln Ala Asp 
            260                 265                 270         


Val Arg Leu Glu Ala Thr Glu Glu Ile Tyr Leu Thr Pro Val Gln Arg 
        275                 280                 285             


Pro Pro Asp Ala Ala Glu Pro Thr Ser Ala Phe Leu Pro Pro Thr Glu 
    290                 295                 300                 


Ser Arg Met Ser Val Ser Ser Asp Pro Asp Pro Ala Ala Tyr Pro Ser 
305                 310                 315                 320 


Thr Ala Gly Arg Pro His Pro Ser Ile Ser Glu Glu Glu Glu Gly Phe 
                325                 330                 335     


Asp Cys Leu Ser Ser Pro Glu Arg Ala Glu Pro Pro Gly Gly Gly Trp 
            340                 345                 350         


Arg Gly Ser Leu Gly Glu Pro Pro Pro Pro Pro Arg Ala Ser Leu Ser 
        355                 360                 365             


Ser Asp Thr Ser Ala Leu Ser Tyr Asp Ser Val Lys Tyr Thr Leu Val 
    370                 375                 380                 


Val Asp Glu His Ala Gln Leu Glu Leu Val Ser Leu Arg Pro Cys Phe 
385                 390                 395                 400 


Gly Asp Tyr Ser Asp Glu Ser Asp Ser Ala Thr Val Tyr Asp Asn Cys 
                405                 410                 415     


Ala Ser Val Ser Ser Pro Tyr Glu Ser Ala Ile Gly Glu Glu Tyr Glu 
            420                 425                 430         


Glu Ala Pro Arg Pro Gln Pro Pro Ala Cys Leu Ser Glu Asp Ser Thr 
        435                 440                 445             


Pro Asp Glu Pro Asp Val His Phe Ser Lys Lys Phe Leu Asn Val Phe 
    450                 455                 460                 


Met Ser Gly Arg Ser Arg Ser Ser Ser Ala Glu Ser Phe Gly Leu Phe 
465                 470                 475                 480 


Ser Cys Ile Ile Asn Gly Glu Glu Gln Glu Gln Thr His Arg Ala Ile 
                485                 490                 495     


Phe Arg Phe Val Pro Arg His Glu Asp Glu Leu Glu Leu Glu Val Asp 
            500                 505                 510         


Asp Pro Leu Leu Val Glu Leu Gln Ala Glu Asp Tyr Trp Tyr Glu Ala 
        515                 520                 525             


Tyr Asn Met Arg Thr Gly Ala Arg Gly Val Phe Pro Ala Tyr Tyr Ala 
    530                 535                 540                 


Ile Glu Val Thr Lys Glu Pro Glu His Met Ala Ala Leu Ala Lys Asn 
545                 550                 555                 560 


Ser Asp Trp Val Asp Gln Phe Arg Val Lys Phe Leu Gly Ser Val Gln 
                565                 570                 575     


Val Pro Tyr His Lys Gly Asn Asp Val Leu Cys Ala Ala Met Gln Lys 
            580                 585                 590         


Ile Ala Thr Thr Arg Arg Leu Thr Val His Phe Asn Pro Pro Ser Ser 
        595                 600                 605             


Cys Val Leu Glu Ile Ser Val Arg Gly Val Lys Gly Val Lys Ala Asp 
    610                 615                 620                 


Asp Ser Gln Glu Ala Lys Gly Asn Lys Cys Ser His Phe Phe Gln Leu 
625                 630                 635                 640 


Lys Asn Ile Ser Phe Cys Gly Tyr His Pro Lys Asn Asn Lys Tyr Phe 
                645                 650                 655     


Gly Phe Ile Thr Lys His Pro Ala Asp His Arg Phe Ala Cys His Val 
            660                 665                 670         


Phe Val Ser Glu Asp Ser Thr Lys Ala Leu Ala Glu Ser Val Gly Arg 
        675                 680                 685             


Ala Phe Gln Gln Phe Tyr Lys Gln Phe Val Glu Tyr Thr Cys Pro Thr 
    690                 695                 700                 


Glu Asp Ile Tyr Leu Glu 
705                 710 


<210> 209  
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 209  
Tyr Gly Phe Gly Gly 
1               5   


<210> 210  
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 210  
Tyr Cys Trp Ser Gln Tyr Leu Cys Tyr 
1               5                   


<210> 211  
<211> 28
<212> PRT
<213> Homo sapiens

<400> 211  
His Ser Asp Ala Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn 
            20                  25              


<210> 212  
<211> 9
<212> PRT
<213> Homo sapiens

<400> 212  
Ser Ala Leu Leu Arg Ser Ile Pro Ala 
1               5                   


<210> 213  
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 213  
Leu Glu Glu Lys Lys Gly Asn Tyr Val Val Thr Asp His Cys 
1               5                   10                  


<210> 214  
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 214  
Asn Phe Gly Ala Ile Leu 
1               5       


<210> 215  
<211> 312
<212> PRT
<213> Homo sapiens

<400> 215  
Met Ala Lys Val Phe Ser Phe Ile Leu Val Thr Thr Ala Leu Thr Met 
1               5                   10                  15      


Gly Arg Glu Ile Ser Ala Leu Glu Asp Cys Ala Gln Glu Gln Met Arg 
            20                  25                  30          


Leu Arg Ala Gln Val Arg Leu Leu Glu Thr Arg Val Lys Gln Gln Gln 
        35                  40                  45              


Val Lys Ile Lys Gln Leu Leu Gln Glu Asn Glu Val Gln Phe Leu Asp 
    50                  55                  60                  


Lys Gly Asp Glu Asn Thr Val Ile Asp Leu Gly Ser Lys Arg Gln Tyr 
65                  70                  75                  80  


Ala Asp Cys Ser Glu Ile Phe Asn Asp Gly Tyr Lys Leu Ser Gly Phe 
                85                  90                  95      


Tyr Lys Ile Lys Pro Leu Gln Ser Pro Ala Glu Phe Ser Val Tyr Cys 
            100                 105                 110         


Asp Met Ser Asp Gly Gly Gly Trp Thr Val Ile Gln Arg Arg Ser Asp 
        115                 120                 125             


Gly Ser Glu Asn Phe Asn Arg Gly Trp Lys Asp Tyr Glu Asn Gly Phe 
    130                 135                 140                 


Gly Asn Phe Val Gln Lys His Gly Glu Tyr Trp Leu Gly Asn Lys Asn 
145                 150                 155                 160 


Leu His Phe Leu Thr Thr Gln Glu Asp Tyr Thr Leu Lys Ile Asp Leu 
                165                 170                 175     


Ala Asp Phe Glu Lys Asn Ser Arg Tyr Ala Gln Tyr Lys Asn Phe Lys 
            180                 185                 190         


Val Gly Asp Glu Lys Asn Phe Tyr Glu Leu Asn Ile Gly Glu Tyr Ser 
        195                 200                 205             


Gly Thr Ala Gly Asp Ser Leu Ala Gly Asn Phe His Pro Glu Val Gln 
    210                 215                 220                 


Trp Trp Ala Ser His Gln Arg Met Lys Phe Ser Thr Trp Asp Arg Asp 
225                 230                 235                 240 


His Asp Asn Tyr Glu Gly Asn Cys Ala Glu Glu Asp Gln Ser Gly Trp 
                245                 250                 255     


Trp Phe Asn Arg Cys His Ser Ala Asn Leu Asn Gly Val Tyr Tyr Ser 
            260                 265                 270         


Gly Pro Tyr Thr Ala Lys Thr Asp Asn Gly Ile Val Trp Tyr Thr Trp 
        275                 280                 285             


His Gly Trp Trp Tyr Ser Leu Lys Ser Val Val Met Lys Ile Arg Pro 
    290                 295                 300                 


Asn Asp Phe Ile Pro Asn Val Ile 
305                 310         


<210> 216  
<211> 64
<212> PRT
<213> Homo sapiens

<400> 216  
Met Ala Lys Val Phe Ser Phe Ile Leu Val Thr Thr Ala Leu Thr Met 
1               5                   10                  15      


Gly Arg Glu Ile Ser Ala Leu Glu Asp Cys Ala Gln Glu Gln Met Arg 
            20                  25                  30          


Leu Arg Ala Gln Val Arg Leu Leu Glu Thr Arg Val Lys Gln Gln Gln 
        35                  40                  45              


Val Lys Ile Lys Gln Leu Leu Gln Glu Asn Glu Val Gln Phe Leu Asp 
    50                  55                  60                  


<210> 217  
<211> 19
<212> PRT
<213> Vibrio cholerae

<400> 217  
Asn Leu Ile Asp Cys Cys Glu Ile Cys Cys Asn Pro Ala Cys Phe Gly 
1               5                   10                  15      


Cys Leu Asn 
            


<210> 218  
<211> 83
<212> PRT
<213> Laticauda semifasciata

<400> 218  
Met Lys Thr Leu Leu Leu Thr Leu Val Val Val Thr Ile Val Cys Leu 
1               5                   10                  15      


Asp Leu Gly Tyr Thr Arg Ile Cys Phe Asn His Gln Ser Ser Gln Pro 
            20                  25                  30          


Gln Thr Thr Lys Thr Cys Ser Pro Gly Glu Ser Ser Cys Tyr Asn Lys 
        35                  40                  45              


Gln Trp Ser Asp Phe Arg Gly Thr Ile Ile Glu Arg Gly Cys Gly Cys 
    50                  55                  60                  


Pro Thr Val Lys Pro Gly Ile Lys Leu Ser Cys Cys Glu Ser Glu Val 
65                  70                  75                  80  


Cys Asn Asn 
            


<210> 219  
<211> 141
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polypeptide"  

<400> 219  
Met Ser Asn Lys Lys Ile Ile Lys Ile Ile Lys Leu Gln Ile Pro Gly 
1               5                   10                  15      


Gly Lys Ala Asn Pro Ala Pro Pro Ile Gly Pro Ala Leu Gly Ala Ala 
            20                  25                  30          


Gly Val Asn Ile Met Gly Phe Cys Lys Glu Phe Asn Ala Ala Thr Gln 
        35                  40                  45              


Asp Arg Pro Gly Asp Leu Leu Pro Val Val Ile Thr Val Tyr Ser Asp 
    50                  55                  60                  


Lys Thr Phe Ser Phe Val Met Lys Gln Ser Pro Val Ser Ser Leu Ile 
65                  70                  75                  80  


Lys Lys Ala Leu Gly Leu Glu Ser Gly Ser Lys Ile Pro Asn Arg Asn 
                85                  90                  95      


Lys Val Gly Lys Leu Thr Arg Ala Gln Ile Thr Val Ile Ala Glu Gln 
            100                 105                 110         


Lys Met Lys Asp Met Asp Val Val Leu Leu Glu Ser Ala Glu Arg Met 
        115                 120                 125             


Val Glu Gly Thr Ala Arg Ser Met Gly Val Asp Val Glu 
    130                 135                 140     


<210> 220  
<211> 172
<212> PRT
<213> Mus musculus

<400> 220  
Met Ser Val Pro Glu Pro Pro Pro Pro Asp Gly Val Leu Thr Gly Pro 
1               5                   10                  15      


Ser Asp Ser Leu Glu Ala Gly Glu Pro Thr Pro Gly Leu Ser Asp Thr 
            20                  25                  30          


Ser Pro Asp Glu Gly Leu Ile Glu Asp Phe Pro Val Asp Asp Arg Ala 
        35                  40                  45              


Val Glu His Leu Val Gly Gly Leu Leu Ser His Tyr Leu Pro Asp Leu 
    50                  55                  60                  


Gln Arg Ser Lys Arg Ala Leu Gln Glu Leu Thr Gln Asn Gln Val Val 
65                  70                  75                  80  


Leu Leu Asp Thr Leu Glu Gln Glu Ile Ser Lys Phe Lys Glu Cys His 
                85                  90                  95      


Ser Met Leu Asp Ile Asn Ala Leu Phe Thr Glu Ala Lys His Tyr His 
            100                 105                 110         


Ala Lys Leu Val Thr Ile Arg Lys Glu Met Leu Leu Leu His Glu Lys 
        115                 120                 125             


Thr Ser Lys Leu Lys Lys Arg Ala Leu Lys Leu Gln Gln Lys Arg Gln 
    130                 135                 140                 


Arg Glu Glu Leu Glu Arg Glu Gln Gln Arg Glu Lys Glu Phe Glu Arg 
145                 150                 155                 160 


Glu Lys Gln Leu Thr Ala Lys Pro Ala Lys Arg Thr 
                165                 170         


<210> 221  
<211> 90
<212> PRT
<213> Human immunodeficiency virus type 1

<400> 221  
Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Thr Asp Leu Asp Leu 
1               5                   10                  15      


Arg Asn Thr Thr Asn Asn Thr Thr Thr Glu Glu Arg Gly Glu Met Lys 
            20                  25                  30          


Asn Cys Ser Phe Asn Ile Thr Thr Asn Ile Arg Asp Arg Tyr Gln Lys 
        35                  40                  45              


Glu Tyr Ala Leu Phe Tyr Lys Leu Asp Val Ile Pro Ile Lys Glu Asp 
    50                  55                  60                  


Asn Thr Ser Asp Asn Thr Ser Tyr Arg Leu Ile Ser Cys Asn Thr Ser 
65                  70                  75                  80  


Val Ile Thr Gln Ala Cys Pro Lys Ile Ser 
                85                  90  


<210> 222  
<211> 191
<212> PRT
<213> Bubalus bubalis

<400> 222  
Ala Phe Pro Ala Met Ser Leu Ser Ser Leu Phe Ala Asn Ala Val Leu 
1               5                   10                  15      


Arg Ala Gln His Leu His Gln Leu Ala Ala Asp Thr Phe Lys Glu Phe 
            20                  25                  30          


Glu Arg Thr Tyr Ile Pro Glu Gly Gln Arg Tyr Ser Ile Gln Asn Thr 
        35                  40                  45              


Gln Val Ala Phe Cys Phe Ser Glu Thr Ile Pro Ala Pro Thr Gly Lys 
    50                  55                  60                  


Asn Glu Ala Gln Gln Lys Ser Asp Leu Glu Leu Leu Arg Ile Ser Leu 
65                  70                  75                  80  


Leu Leu Ile Gln Ser Trp Leu Gly Pro Leu Gln Phe Leu Ser Arg Val 
                85                  90                  95      


Phe Thr Asn Ser Leu Val Phe Gly Thr Ser Asp Arg Val Tyr Glu Lys 
            100                 105                 110         


Leu Lys Asp Leu Glu Glu Gly Ile Leu Ala Leu Met Arg Glu Leu Glu 
        115                 120                 125             


Asp Gly Thr Pro Arg Ala Gly Gln Ile Leu Lys Arg Thr Tyr Asp Lys 
    130                 135                 140                 


Phe Asp Thr Asn Met Arg Ser Asp Asp Ala Leu Leu Lys Asn Tyr Gly 
145                 150                 155                 160 


Leu Leu Ser Cys Phe Arg Lys Asp Leu His Lys Thr Glu Thr Tyr Leu 
                165                 170                 175     


Arg Val Met Lys Cys Arg Arg Phe Gly Glu Ala Ser Cys Ala Phe 
            180                 185                 190     


<210> 223  
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 223  
Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro 
1               5                   10                  


<210> 224  
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 224  
Asn Pro Phe Pro Thr Trp Arg Lys Arg Pro Gly 
1               5                   10      


<210> 225  
<211> 134
<212> PRT
<213> Homo sapiens

<400> 225  
Met Asp Pro Gln Thr Ala Pro Ser Arg Ala Leu Leu Leu Leu Leu Phe 
1               5                   10                  15      


Leu His Leu Ala Phe Leu Gly Gly Arg Ser His Pro Leu Gly Ser Pro 
            20                  25                  30          


Gly Ser Ala Ser Asp Leu Glu Thr Ser Gly Leu Gln Glu Gln Arg Asn 
        35                  40                  45              


His Leu Gln Gly Lys Leu Ser Glu Leu Gln Val Glu Gln Thr Ser Leu 
    50                  55                  60                  


Glu Pro Leu Gln Glu Ser Pro Arg Pro Thr Gly Val Trp Lys Ser Arg 
65                  70                  75                  80  


Glu Val Ala Thr Glu Gly Ile Arg Gly His Arg Lys Met Val Leu Tyr 
                85                  90                  95      


Thr Leu Arg Ala Pro Arg Ser Pro Lys Met Val Gln Gly Ser Gly Cys 
            100                 105                 110         


Phe Gly Arg Lys Met Asp Arg Ile Ser Ser Ser Ser Gly Leu Gly Cys 
        115                 120                 125             


Lys Val Leu Arg Arg His 
    130                 


<210> 226  
<211> 87
<212> PRT
<213> Heloderma suspectum

<400> 226  
Met Lys Ile Ile Leu Trp Leu Cys Val Phe Gly Leu Phe Leu Ala Thr 
1               5                   10                  15      


Leu Phe Pro Ile Ser Trp Gln Met Pro Val Glu Ser Gly Leu Ser Ser 
            20                  25                  30          


Glu Asp Ser Ala Ser Ser Glu Ser Phe Ala Ser Lys Ile Lys Arg His 
        35                  40                  45              


Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu Glu 
    50                  55                  60                  


Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Ser 
65                  70                  75                  80  


Gly Ala Pro Pro Pro Ser Gly 
                85          


<210> 227  
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 227  
His Gly Val Ser Gly His Gly Gln His Gly Val His Gly 
1               5                   10              


<210> 228  
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> misc_feature
<222> (1)..(1)
<223> /note="N-term acetylated"

<220>
<221> misc_feature
<222> (9)..(9)
<223> /note="C-term amidated"

<400> 228  
Lys Trp Arg Arg Trp Val Arg Trp Ile 
1               5                   


<210> 229  
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 229  
Lys Phe His Glu Lys His His Ser His Arg Gly Tyr 
1               5                   10          


<210> 230  
<211> 51
<212> PRT
<213> Homo sapiens

<400> 230  
Met Lys Phe Phe Val Phe Ala Leu Ile Leu Ala Leu Met Leu Ser Met 
1               5                   10                  15      


Thr Gly Ala Asp Ser His Ala Lys Arg His His Gly Tyr Lys Arg Lys 
            20                  25                  30          


Phe His Glu Lys His His Ser His Arg Gly Tyr Arg Ser Asn Tyr Leu 
        35                  40                  45              


Tyr Asp Asn 
    50      


<210> 231  
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 231  
Met Gln Cys Asn Ser 
1               5   


<210> 232  
<211> 390
<212> PRT
<213> Homo sapiens

<400> 232  
Met Pro Pro Ser Gly Leu Arg Leu Leu Pro Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 
            20                  25                  30          


Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                  40                  45              


Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 
    50                  55                  60                  


Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 
65                  70                  75                  80  


Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu 
                85                  90                  95      


Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 
            100                 105                 110         


Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr 
        115                 120                 125             


His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 
    130                 135                 140                 


Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu 
145                 150                 155                 160 


Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                 170                 175     


Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser 
            180                 185                 190         


Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                 200                 205             


Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Cys Ser 
    210                 215                 220                 


Cys Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr 
225                 230                 235                 240 


Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 
                245                 250                 255     


Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu Gln 
            260                 265                 270         


Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 
        275                 280                 285             


Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 
    290                 295                 300                 


Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 
305                 310                 315                 320 


Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 
                325                 330                 335     


Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 
            340                 345                 350         


Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 
        355                 360                 365             


Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 
    370                 375                 380                 


Arg Ser Cys Lys Cys Ser 
385                 390 


<210> 233  
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 233  
Cys Asn Gly Arg Cys Gly 
1               5       


<210> 234  
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 234  
Val Pro Val Asp 
1               


<210> 235  
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 235  
Val Pro Asp Pro Arg 
1               5   


<210> 236  
<211> 348
<212> PRT
<213> Homo sapiens

<400> 236  
Met Leu Gln Thr Lys Asp Leu Ile Trp Thr Leu Phe Phe Leu Gly Thr 
1               5                   10                  15      


Ala Val Ser Leu Gln Val Asp Ile Val Pro Ser Gln Gly Glu Ile Ser 
            20                  25                  30          


Val Gly Glu Ser Lys Phe Phe Leu Cys Gln Val Ala Gly Asp Ala Lys 
        35                  40                  45              


Asp Lys Asp Ile Ser Trp Phe Ser Pro Asn Gly Glu Lys Leu Thr Pro 
    50                  55                  60                  


Asn Gln Gln Arg Ile Ser Val Val Trp Asn Asp Asp Ser Ser Ser Thr 
65                  70                  75                  80  


Leu Thr Ile Tyr Asn Ala Asn Ile Asp Asp Ala Gly Ile Tyr Lys Cys 
                85                  90                  95      


Val Val Thr Gly Glu Asp Gly Ser Glu Ser Glu Ala Thr Val Asn Val 
            100                 105                 110         


Lys Ile Phe Gln Lys Leu Met Phe Lys Asn Ala Pro Thr Pro Gln Glu 
        115                 120                 125             


Phe Arg Glu Gly Glu Asp Ala Val Ile Val Cys Asp Val Val Ser Ser 
    130                 135                 140                 


Leu Pro Pro Thr Ile Ile Trp Lys His Lys Gly Arg Asp Val Ile Leu 
145                 150                 155                 160 


Lys Lys Asp Val Arg Phe Ile Phe Leu Ser Asn Asn Tyr Leu Pro Ile 
                165                 170                 175     


Pro Gly Ile Lys Lys Thr Asp Glu Gly Thr Tyr Arg Cys Glu Gly Arg 
            180                 185                 190         


Ile Leu Ala Arg Gly Glu Ile Asn Phe Asn Asp Ile Gln Val Ile Val 
        195                 200                 205             


Asn Val Pro Pro Thr Ile Gln Ala Arg Gln Asn Ile Val Asn Ala Thr 
    210                 215                 220                 


Ala Asn Leu Gly Gln Ser Val Thr Leu Val Cys Asp Ala Glu Gly Phe 
225                 230                 235                 240 


Pro Gly Pro Thr Met Ser Trp Thr Lys Asp Gly Glu Gln Ile Glu Gln 
                245                 250                 255     


Glu Glu His Asp Glu Lys Tyr Leu Phe Ser Asp Asp Ser Ser His Leu 
            260                 265                 270         


Thr Ile Lys Lys Val Asp Lys Asn His Glu Ala Glu Asn Ile Cys Ile 
        275                 280                 285             


Ala Glu Asn Lys Val Gly Glu Gln Asp Ala Thr Ile His Leu Lys Val 
    290                 295                 300                 


Phe Ala Lys Pro Gln Ile Thr Tyr Val Glu Asp Gln Thr Ala Met Glu 
305                 310                 315                 320 


Leu Ala Glu Gln Val Ile Leu Thr Val Glu Ala Ser Gly Asp His Ile 
                325                 330                 335     


Pro Tyr Ile Thr Trp Trp Thr Ser Thr Trp Gln Ile 
            340                 345             


<210> 237  
<211> 153
<212> PRT
<213> Homo sapiens

<400> 237  
Met Val Ala Thr Lys Thr Phe Ala Leu Leu Leu Leu Ser Leu Phe Leu 
1               5                   10                  15      


Ala Val Gly Leu Gly Glu Lys Lys Glu Gly His Phe Ser Ala Leu Pro 
            20                  25                  30          


Ser Leu Pro Val Gly Ser His Ala Lys Val Ser Ser Pro Gln Pro Arg 
        35                  40                  45              


Gly Pro Arg Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala 
    50                  55                  60                  


Met Asp Lys Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln 
65                  70                  75                  80  


Lys Gly Lys Lys Asn Asp Trp Lys His Asn Ile Thr Gln Arg Glu Ala 
                85                  90                  95      


Arg Ala Leu Glu Leu Ala Ser Gln Ala Asn Arg Lys Glu Glu Glu Ala 
            100                 105                 110         


Val Glu Pro Gln Ser Ser Pro Ala Lys Asn Pro Ser Asp Glu Asp Leu 
        115                 120                 125             


Leu Arg Asp Leu Leu Ile Gln Glu Leu Leu Ala Cys Leu Leu Asp Gln 
    130                 135                 140                 


Thr Asn Leu Cys Arg Leu Arg Ser Arg 
145                 150             


<210> 238  
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 238  
Glu Leu Tyr Ser Ala Leu Ala Asn Lys Cys Cys His Val Gly Cys Thr 
1               5                   10                  15      


Lys Arg Ser Leu Ala Arg Phe Cys 
            20                  


<210> 239  
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 239  
Asp Ser Trp Met Glu Glu Val Ile Lys Leu Cys Gly Arg Glu Leu Val 
1               5                   10                  15      


Arg Ala Gln Ile Ala Ile Cys Gly Met Ser Thr Ser 
            20                  25              


<210> 240  
<211> 31
<212> PRT
<213> Homo sapiens

<400> 240  
Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro 
1               5                   10                  15      


Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln 
            20                  25                  30      


<210> 241  
<211> 80
<212> PRT
<213> Homo sapiens

<400> 241  
Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Ser Ser Thr 
65                  70                  75                  80  


<210> 242  
<211> 83
<212> PRT
<213> Bitis arietans

<400> 242  
Ser Pro Pro Val Cys Gly Asn Lys Ile Leu Glu Gln Gly Glu Asp Cys 
1               5                   10                  15      


Asp Cys Gly Ser Pro Ala Asn Cys Gln Asp Arg Cys Cys Asn Ala Ala 
            20                  25                  30          


Thr Cys Lys Leu Thr Pro Gly Ser Gln Cys Asn Tyr Gly Glu Cys Cys 
        35                  40                  45              


Asp Gln Cys Arg Phe Lys Lys Ala Gly Thr Val Cys Arg Ile Ala Arg 
    50                  55                  60                  


Gly Asp Trp Asn Asp Asp Tyr Cys Thr Gly Lys Ser Ser Asp Cys Pro 
65                  70                  75                  80  


Trp Asn His 
            


<210> 243  
<211> 50
<212> PRT
<213> Homo sapiens

<400> 243  
Met Glu Cys Glu Ser Gly Pro Cys Cys Arg Asn Cys Lys Phe Leu Lys 
1               5                   10                  15      


Glu Gly Thr Ile Cys Lys Arg Ala Arg Gly Asp Asp Leu Asp Asp Tyr 
            20                  25                  30          


Cys Asn Gly Lys Thr Cys Asp Cys Pro Arg Asn Pro His Lys Gly Pro 
        35                  40                  45              


Ala Thr 
    50  


<210> 244  
<211> 82
<212> PRT
<213> Homo sapiens

<400> 244  
Glu Ala Ser Trp Lys Pro Arg Ser Gln Gln Pro Asp Ala Pro Leu Gly 
1               5                   10                  15      


Thr Gly Ala Asn Arg Asp Leu Glu Leu Pro Trp Leu Glu Gln Gln Gly 
            20                  25                  30          


Pro Ala Ser His His Arg Arg Gln Leu Gly Pro Gln Gly Pro Pro His 
        35                  40                  45              


Leu Val Ala Asp Pro Ser Lys Lys Gln Gly Pro Trp Leu Glu Glu Glu 
    50                  55                  60                  


Glu Glu Ala Tyr Gly Trp Met Asp Phe Gly Arg Arg Ser Ala Glu Asp 
65                  70                  75                  80  


Glu Asn 
        


<210> 245  
<211> 23
<212> PRT
<213> Human herpesvirus 1

<400> 245  
Met Gly Gly Ala Ala Ala Arg Leu Gly Ala Val Ile Leu Phe Val Val 
1               5                   10                  15      


Ile Val Gly Leu His Gly Val 
            20              


<210> 246  
<211> 12
<212> PRT
<213> Homo sapiens

<400> 246  
Leu Tyr Glu Asn Lys Pro Arg Arg Pro Tyr Ile Leu 
1               5                   10          


<210> 247  
<211> 176
<212> PRT
<213> Homo sapiens

<400> 247  
Met Lys Val Leu Leu Cys Asp Leu Leu Leu Leu Ser Leu Phe Ser Ser 
1               5                   10                  15      


Val Phe Ser Ser Cys Gln Arg Asp Cys Leu Thr Cys Gln Glu Lys Leu 
            20                  25                  30          


His Pro Ala Leu Asp Ser Phe Asp Leu Glu Val Cys Ile Leu Glu Cys 
        35                  40                  45              


Glu Glu Lys Val Phe Pro Ser Pro Leu Trp Thr Pro Cys Thr Lys Val 
    50                  55                  60                  


Met Ala Arg Ser Ser Trp Gln Leu Ser Pro Ala Ala Pro Glu His Val 
65                  70                  75                  80  


Ala Ala Ala Leu Tyr Gln Pro Arg Ala Ser Glu Met Gln His Leu Arg 
                85                  90                  95      


Arg Met Pro Arg Val Arg Ser Leu Phe Gln Glu Gln Glu Glu Pro Glu 
            100                 105                 110         


Pro Gly Met Glu Glu Ala Gly Glu Met Glu Gln Lys Gln Leu Gln Lys 
        115                 120                 125             


Arg Phe Gly Gly Phe Thr Gly Ala Arg Lys Ser Ala Arg Lys Leu Ala 
    130                 135                 140                 


Asn Gln Lys Arg Phe Ser Glu Phe Met Arg Gln Tyr Leu Val Leu Ser 
145                 150                 155                 160 


Met Gln Ser Ser Gln Arg Arg Arg Thr Leu His Gln Asn Gly Asn Val 
                165                 170                 175     


<210> 248  
<211> 37
<212> PRT
<213> Homo sapiens

<400> 248  
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210> 249  
<211> 49
<212> PRT
<213> Sus scrofa

<400> 249  
Gly Trp Pro Gln Ala Pro Ala Met Asp Gly Ala Gly Lys Thr Gly Ala 
1               5                   10                  15      


Glu Glu Ala Gln Pro Pro Glu Gly Lys Gly Ala Arg Glu His Ser Arg 
            20                  25                  30          


Gln Glu Glu Glu Glu Glu Thr Ala Gly Ala Pro Gln Gly Leu Phe Arg 
        35                  40                  45              


Gly 
    


<210> 250  
<211> 185
<212> PRT
<213> Homo sapiens

<400> 250  
Met Pro Arg Leu Phe Leu Phe His Leu Leu Glu Phe Cys Leu Leu Leu 
1               5                   10                  15      


Asn Gln Phe Ser Arg Ala Val Ala Ala Lys Trp Lys Asp Asp Val Ile 
            20                  25                  30          


Lys Leu Cys Gly Arg Glu Leu Val Arg Ala Gln Ile Ala Ile Cys Gly 
        35                  40                  45              


Met Ser Thr Trp Ser Lys Arg Ser Leu Ser Gln Glu Asp Ala Pro Gln 
    50                  55                  60                  


Thr Pro Arg Pro Val Ala Glu Ile Val Pro Ser Phe Ile Asn Lys Asp 
65                  70                  75                  80  


Thr Glu Thr Ile Ile Ile Met Leu Glu Phe Ile Ala Asn Leu Pro Pro 
                85                  90                  95      


Glu Leu Lys Ala Ala Leu Ser Glu Arg Gln Pro Ser Leu Pro Glu Leu 
            100                 105                 110         


Gln Gln Tyr Val Pro Ala Leu Lys Asp Ser Asn Leu Ser Phe Glu Glu 
        115                 120                 125             


Phe Lys Lys Leu Ile Arg Asn Arg Gln Ser Glu Ala Ala Asp Ser Asn 
    130                 135                 140                 


Pro Ser Glu Leu Lys Tyr Leu Gly Leu Asp Thr His Ser Gln Lys Lys 
145                 150                 155                 160 


Arg Arg Pro Tyr Val Ala Leu Phe Glu Lys Cys Cys Leu Ile Gly Cys 
                165                 170                 175     


Thr Lys Arg Ser Leu Ala Lys Tyr Cys 
            180                 185 


<210> 251  
<211> 27
<212> PRT
<213> Homo sapiens

<400> 251  
His Ser Asp Gly Thr Phe Thr Ser Glu Leu Ser Arg Leu Arg Glu Gly 
1               5                   10                  15      


Ala Arg Leu Gln Arg Leu Leu Gln Gly Leu Val 
            20                  25          


<210> 252  
<211> 207
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polypeptide"  

<400> 252  
Met Ala Pro Phe Glu Pro Leu Ala Ser Gly Ile Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ile Ala Pro Ser Arg Ala Cys Thr Cys Val Pro Pro His Pro Gln 
            20                  25                  30          


Thr Ala Phe Cys Asn Ser Asp Leu Val Ile Arg Ala Lys Phe Val Gly 
        35                  40                  45              


Thr Pro Glu Val Asn Gln Thr Thr Leu Tyr Gln Arg Tyr Glu Ile Lys 
    50                  55                  60                  


Met Thr Lys Met Tyr Lys Gly Phe Gln Ala Leu Gly Asp Ala Ala Asp 
65                  70                  75                  80  


Ile Arg Phe Val Tyr Thr Pro Ala Met Glu Ser Val Cys Gly Tyr Phe 
                85                  90                  95      


His Arg Ser His Asn Arg Ser Glu Glu Phe Leu Ile Ala Gly Lys Leu 
            100                 105                 110         


Gln Asp Gly Leu Leu His Ile Thr Thr Cys Ser Phe Val Ala Pro Trp 
        115                 120                 125             


Asn Ser Leu Ser Leu Ala Gln Arg Arg Gly Phe Thr Lys Thr Tyr Thr 
    130                 135                 140                 


Val Gly Cys Glu Glu Cys Thr Val Phe Pro Cys Leu Ser Ile Pro Cys 
145                 150                 155                 160 


Lys Leu Gln Ser Gly Thr His Cys Leu Trp Thr Asp Gln Leu Leu Gln 
                165                 170                 175     


Gly Ser Glu Lys Gly Phe Gln Ser Arg His Leu Ala Cys Leu Pro Arg 
            180                 185                 190         


Glu Pro Gly Leu Cys Thr Trp Gln Ser Leu Arg Ser Gln Ile Ala 
        195                 200                 205         


<210> 253  
<211> 74
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polypeptide"  

<400> 253  
Asp Thr Thr Val Ser Glu Pro Ala Pro Ser Cys Val Thr Leu Tyr Gln 
1               5                   10                  15      


Ser Trp Arg Tyr Ser Gln Ala Asp Asn Gly Cys Ala Gln Thr Val Thr 
            20                  25                  30          


Val Lys Val Val Tyr Glu Asp Asp Thr Glu Gly Leu Cys Tyr Ala Val 
        35                  40                  45              


Ala Pro Gly Gln Ile Thr Thr Val Gly Asp Gly Tyr Ile Gly Ser His 
    50                  55                  60                  


Gly His Ala Arg Tyr Leu Ala Arg Cys Leu 
65                  70                  


<210> 254  
<211> 44
<212> PRT
<213> Homo sapiens

<400> 254  
Met Ser Asp Lys Pro Asp Met Ala Glu Ile Glu Lys Phe Asp Lys Ser 
1               5                   10                  15      


Lys Leu Lys Lys Thr Glu Thr Gln Glu Lys Asn Pro Leu Pro Ser Lys 
            20                  25                  30          


Glu Thr Ile Glu Gln Glu Lys Gln Ala Gly Glu Ser 
        35                  40                  


<210> 255  
<211> 32
<212> PRT
<213> Rana tigrina

<400> 255  
Thr Ala Pro Arg Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met 
1               5                   10                  15      


Asp Arg Ile Gly Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr 
            20                  25                  30          


<210> 256  
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 256  
Gly Ser Arg Ala His Ser Ser His Leu Lys 
1               5                   10  


<210> 257  
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 257  
Glu Leu Lys Cys Tyr Thr Cys Lys Glu Pro Met Thr Ser Ala Ala Cys 
1               5                   10                  15      


<210> 258  
<211> 4
<212> PRT
<213> Homo sapiens

<400> 258  
Asp Ala His Lys 
1               


<210> 259  
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polypeptide"  

<400> 259  
Lys Met Val Gln Gly Ser Gly Cys Phe Gly Arg Lys Met Asp Ile Ser 
1               5                   10                  15      


Ser Ser Ser Gly Leu Gly Cys Pro Ser Leu Arg Asp Pro Arg Pro Asn 
            20                  25                  30          


Ala Pro Ser Thr Ser Ala 
        35              


<210> 260  
<211> 54
<212> PRT
<213> Homo sapiens


<220>
<221> misc_feature
<222> (54)..(54)
<223> /note="C-term amidated"

<400> 260  
Gly Thr Ser Leu Ser Pro Pro Pro Glu Ser Ser Gly Ser Pro Gln Gln 
1               5                   10                  15      


Pro Gly Leu Ser Ala Pro His Ser Arg Gln Ile Pro Ala Pro Gln Gly 
            20                  25                  30          


Ala Val Leu Val Gln Arg Glu Lys Asp Leu Pro Asn Tyr Asn Trp Asn 
        35                  40                  45              


Ser Phe Gly Leu Arg Phe 
    50                  


<210> 261  
<211> 14
<212> PRT
<213> Homo sapiens


<220>
<221> misc_feature
<222> (14)..(14)
<223> /note="C-term amidated"

<400> 261  
Asp Leu Pro Asn Tyr Asn Trp Asn Ser Phe Gly Leu Arg Phe 
1               5                   10                  


<210> 262  
<211> 13
<212> PRT
<213> Homo sapiens


<220>
<221> misc_feature
<222> (13)..(13)
<223> /note="C-term amidated"

<400> 262  
Leu Pro Asn Tyr Asn Trp Asn Ser Phe Gly Leu Arg Phe 
1               5                   10              


<210> 263  
<211> 10
<212> PRT
<213> Homo sapiens


<220>
<221> misc_feature
<222> (10)..(10)
<223> /note="C-term amidated"

<400> 263  
Tyr Asn Trp Asn Ser Phe Gly Leu Arg Phe 
1               5                   10  


<210> 264  
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> misc_feature
<222> (1)..(16)
<223> /note="Disulfide bridge"

<220>
<221> misc_feature
<222> (8)..(20)
<223> /note="Disulfide bridge"

<220>
<221> misc_feature
<222> (15)..(25)
<223> /note="Disulfide bridge"

<220>
<221> misc_feature
<222> (25)..(25)
<223> /note="C-term amidated"

<400> 264  
Cys Lys Gly Lys Gly Ala Lys Cys Ser Arg Leu Met Tyr Asp Cys Cys 
1               5                   10                  15      


Thr Gly Ser Cys Arg Ser Gly Lys Cys 
            20                  25  


<210> 265  
<211> 18
<212> PRT
<213> Sus scrofa 


<220>
<221> misc_feature
<222> (18)..(18)
<223> /note="C-term amidated"

<400> 265  
Arg Gly Gly Arg Leu Cys Tyr Cys Arg Arg Arg Phe Cys Val Cys Val 
1               5                   10                  15      


Gly Arg 
        


<210> 266  
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> misc_feature
<222> (1)..(1)
<223> /note="N-term acetylated"

<220>
<221> misc_feature
<222> (26)..(26)
<223> /note="C-term amidated"

<400> 266  
Lys Trp Lys Ser Phe Leu Lys Thr Phe Lys Ser Ala Val Lys Thr Val 
1               5                   10                  15      


Leu His Thr Ala Leu Lys Ala Ile Ser Ser 
            20                  25      


<210> 267  
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 267  
Lys Trp Lys Ser Phe Leu Lys Thr Phe Lys Ser Val Lys Thr Val Leu 
1               5                   10                  15      


His Thr Ala Leu Lys Ala Ile Ser Ser 
            20                  25  


<210> 268  
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 268  
Lys Trp Lys Ser Phe Leu Lys Thr Phe Lys Ser Ala Lys Lys Thr Val 
1               5                   10                  15      


Leu His Thr Ala Leu Lys Ala Ile Ser Ser 
            20                  25      


<210> 269  
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 269  
Lys Trp Lys Ser Phe Leu Lys Thr Phe Lys Ser Ala Lys Lys Lys Val 
1               5                   10                  15      


Leu His Thr Ala Leu Lys Ala Ile Ser Ser 
            20                  25      


<210> 270  
<211> 33
<212> PRT
<213> Homo sapiens

<400> 270  
His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 



<210> 271  
<211> 33
<212> PRT
<213> Homo sapiens

<400> 271  
His Gly Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210> 272  
<211> 34
<212> PRT
<213> Homo sapiens

<400> 272  
His Gly Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp Cys 
        


<210> 273  
<211> 16
<212> PRT
<213> Homo sapiens

<400> 273  
Leu Arg Ile Val Gln Cys Ala Ser Val Glu Gly Ser Cys Gly Phe Tyr 
1               5                   10                  15      


<210> 274  
<211> 16
<212> PRT
<213> Homo sapiens


<220>
<221> misc_feature
<222> (1)..(1)
<223> /note="N-term acetylated" 

<400> 274  
Leu Arg Ile Val Gln Cys Ala Lys Val Glu Gly Ser Cys Gly Phe Tyr 
1               5                   10                  15      


<210> 275  
<211> 17
<212> PRT
<213> Homo sapiens


<220>
<221> misc_feature
<222> (1)..(1)
<223> /note="N-term acetylated"

<400> 275  
Leu Arg Ile Val Gln Cys Ala Ser Val Glu Gly Ser Cys Gly Phe Tyr 
1               5                   10                  15      


Lys 
    


<210> 276  
<211> 31
<212> PRT
<213> Homo sapiens

<400> 276  
Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro 
1               5                   10                  15      


Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln 
            20                  25                  30      


<210> 277  
<211> 16
<212> PRT
<213> Sus scrofa

<400> 277  
Arg Gly Gly Arg Leu Cys Tyr Cys Arg Arg Arg Phe Cys Ile Cys Val 
1               5                   10                  15      


<210> 278  
<211> 19
<212> PRT
<213> Sus scrofa

<400> 278  
Arg Gly Gly Gly Leu Cys Tyr Cys Arg Arg Arg Phe Cys Val Cys Val 
1               5                   10                  15      


Gly Arg Gly 
            


<210> 279  
<211> 19
<212> PRT
<213> Sus scrofa

<400> 279  
Arg Gly Gly Arg Leu Cys Tyr Cys Arg Gly Trp Ile Cys Phe Cys Val 
1               5                   10                  15      


Gly Arg Gly 
            


<210> 280  
<211> 19
<212> PRT
<213> Sus scrofa

<400> 280  
Arg Gly Gly Arg Leu Cys Tyr Cys Arg Pro Arg Phe Cys Val Cys Val 
1               5                   10                  15      


Gly Arg Gly 
            


<210> 281  
<211> 149
<212> PRT
<213> Sus scrofa

<400> 281  
Met Glu Thr Gln Arg Ala Ser Leu Cys Leu Gly Arg Trp Ser Leu Trp 
1               5                   10                  15      


Leu Leu Leu Leu Gly Leu Val Val Pro Ser Ala Ser Ala Gln Ala Leu 
            20                  25                  30          


Ser Tyr Arg Glu Ala Val Leu Arg Ala Val Asp Arg Leu Asn Glu Gln 
        35                  40                  45              


Ser Ser Glu Ala Asn Leu Tyr Arg Leu Leu Glu Leu Asp Gln Pro Pro 
    50                  55                  60                  


Lys Ala Asp Glu Asp Pro Gly Thr Pro Lys Pro Val Ser Phe Thr Val 
65                  70                  75                  80  


Lys Glu Thr Val Cys Pro Arg Pro Thr Arg Gln Pro Pro Glu Leu Cys 
                85                  90                  95      


Asp Phe Lys Glu Asn Gly Arg Val Lys Gln Cys Val Gly Thr Val Thr 
            100                 105                 110         


Leu Asp Gln Ile Lys Asp Pro Leu Asp Ile Thr Cys Asn Glu Val Gln 
        115                 120                 125             


Gly Val Arg Gly Gly Arg Leu Cys Tyr Cys Arg Pro Arg Phe Cys Val 
    130                 135                 140                 


Cys Val Gly Arg Gly 
145                 


<210> 282  
<211> 5
<212> PRT
<213> Homo sapiens

<400> 282  
Glu Gly Ser Leu Cys 
1               5   


<210> 283  
<211> 5
<212> PRT
<213> Homo sapiens

<400> 283  
Tyr Gly Gly Phe Met 
1               5   


<210> 284  
<211> 9
<212> PRT
<213> Homo sapiens


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Tyr(SO3)

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Norleu

<400> 284  
Arg Asp Tyr Thr Gly Trp Leu Asp Phe 
1               5                   


<210> 285  
<211> 13
<212> PRT
<213> Homo sapiens

<400> 285  
Tyr Gly Gly Phe Leu Arg Arg Ile Arg Pro Lys Leu Lys 
1               5                   10              


<210> 286  
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  

<400> 286  
Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly Ala Gln Ser 
1               5                   10                  15      


Gly Leu Gly Cys Asn Ser Phe Arg Tyr 
            20                  25  


<210> 287  
<211> 37
<212> PRT
<213> Homo sapiens

<400> 287  
Glu Val Val Pro Pro Gln Val Leu Ser Asp Pro Asn Glu Glu Ala Gly 
1               5                   10                  15      


Ala Ala Leu Ser Pro Leu Pro Glu Val Pro Pro Trp Thr Gly Glu Val 
            20                  25                  30          


Ser Pro Ala Gln Arg 
        35          


<210> 288  
<211> 65
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polypeptide"  

<400> 288  
Val Val Tyr Thr Asp Cys Thr Glu Ser Gly Gln Asn Leu Cys Leu Cys 
1               5                   10                  15      


Glu Gly Ser Asn Val Cys Gly Gln Gly Asn Lys Cys Ile Leu Gly Ser 
            20                  25                  30          


Asp Gly Glu Lys Asn Gln Cys Val Thr Gly Glu Gly Thr Pro Lys Pro 
        35                  40                  45              


Gln Ser His Asn Asp Gly Asp Phe Glu Glu Ile Pro Glu Glu Tyr Leu 
    50                  55                  60                  


Gln 
65  


<210> 289  
<211> 14
<212> PRT
<213> Homo sapiens

<400> 289  
Ala Leu Lys Arg Gln Gly Arg Thr Leu Tyr Gly Phe Gly Gly 
1               5                   10                  


<210> 290  
<211> 5
<212> PRT
<213> Homo sapiens

<400> 290  
Tyr Gly Phe Gly Gly 
1               5   


<210> 291  
<211> 11
<212> PRT
<213> Homo sapiens


<220>
<221> misc_feature
<222> (1)..(1)
<223> /note="N-term acetylated"

<400> 291  
Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly 
1               5                   10      


<210> 292  
<211> 11
<212> PRT
<213> Homo sapiens


<220>
<221> misc_feature
<222> (1)..(1)
<223> /note="N-term acetylated"

<400> 292  
Ala Ser Gln Tyr Arg Pro Ser Gln Arg His Gly 
1               5                   10      


<210> 293  
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Pyro-Glu

<220>
<221> misc_feature
<222> (10)..(10)
<223> /note="C-term amidated"

<400> 293  
Glu His Trp Ser Tyr Gly Leu Arg Pro Gly 
1               5                   10  


<210> 294  
<211> 15
<212> PRT
<213> Phodopus sp. 

<400> 294  
Gly Leu His Asp Pro Ser His Gly Thr Leu Pro Asn Gly Ser Gly 
1               5                   10                  15  


<210> 295  
<211> 41
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polypeptide"

<400> 295  
Ile Val Leu Ser Leu Asp Val Pro Ile Gly Leu Leu Gln Ile Leu Leu 
1               5                   10                  15      


Glu Gln Ala Arg Ala Arg Ala Ala Arg Glu Gln Ala Thr Thr Asn Ala 
            20                  25                  30          


Arg Ile Leu Ala Arg Val Gly His Cys 
        35                  40      


<210> 296  
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> misc_feature
<222> (8)..(8)
<223> /note="C-term amidated"

<400> 296  
Lys Pro Ser Ser Pro Pro Glu Glu 
1               5               


<210> 297  
<211> 23
<212> PRT
<213> Homo sapiens  


<220>
<221> misc_feature
<222> (23)..(23)
<223> /note="C-term amidated"

<400> 297  
Phe Asn Ala Pro Phe Asp Val Gly Ile Lys Leu Ser Gly Val Gln Tyr 
1               5                   10                  15      


Gln Gln His Ser Gln Ala Leu 
            20              


<210> 298  
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic peptide"  


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Lys(Et)

<400> 298  
Gly Lys Pro Arg 
1               


<210> 299  
<211> 22
<212> PRT
<213> Homo sapiens

<400> 299  
Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210> 300  
<211> 49
<212> PRT
<213> Homo sapiens

<400> 300  
Tyr Leu Tyr Gln Trp Leu Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu 
1               5                   10                  15      


Glu Pro Arg Arg Glu Val Cys Glu Leu Asn Pro Asp Cys Asp Glu Leu 
            20                  25                  30          


Ala Asp His Ile Gly Phe Gln Glu Ala Tyr Arg Arg Phe Tyr Gly Pro 
        35                  40                  45              


Val 
    


<210> 301  
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 
      polypeptide"

<400> 301  
Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro 
1               5                   10                  15      


Gly Ala Gly Cys Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln 
            20                  25                  30      


