                         SEQUENCE LISTING

<110>  Galderma research & Development
 
<120>  Modulateurs de LGR5 dans le traitement de l'alopcie

<130>  OA08310E

<150>  FR0856316
<151>  2008-09-19

<160>  2     

<170>  PatentIn version 3.3

<210>  1
<211>  2880
<212>  DNA
<213>  Homo sapiens

<400>  1
tgctgctctc cgcccgcgtc cggctcgtgg ccccctactt cgggcaccat ggacacctcc     60

cggctcggtg tgctcctgtc cttgcctgtg ctgctgcagc tggcgaccgg gggcagctct    120

cccaggtctg gtgtgttgct gaggggctgc cccacacact gtcattgcga gcccgacggc    180

aggatgttgc tcagggtgga ctgctccgac ctggggctct cggagctgcc ttccaacctc    240

agcgtcttca cctcctacct agacctcagt atgaacaaca tcagtcagct gctcccgaat    300

cccctgccca gtctccgctt cctggaggag ttacgtcttg cgggaaacgc tctgacatac    360

attcccaagg gagcattcac tggcctttac agtcttaaag ttcttatgct gcagaataat    420

cagctaagac acgtacccac agaagctctg cagaatttgc gaagccttca atccctgcgt    480

ctggatgcta accacatcag ctatgtgccc ccaagctgtt tcagtggcct gcattccctg    540

aggcacctgt ggctggatga caatgcgtta acagaaatcc ccgtccaggc ttttagaagt    600

ttatcggcat tgcaagccat gaccttggcc ctgaacaaaa tacaccacat accagactat    660

gcctttggaa acctctccag cttggtagtt ctacatctcc ataacaatag aatccactcc    720

ctgggaaaga aatgctttga tgggctccac agcctagaga ctttagattt aaattacaat    780

aaccttgatg aattccccac tgcaattagg acactctcca accttaaaga actaggattt    840

catagcaaca atatcaggtc gatacctgag aaagcatttg taggcaaccc ttctcttatt    900

acaatacatt tctatgacaa tcccatccaa tttgttggga gatctgcttt tcaacattta    960

cctgaactaa gaacactgac tctgaatggt gcctcacaaa taactgaatt tcctgattta   1020

actggaactg caaacctgga gagtctgact ttaactggag cacagatctc atctcttcct   1080

caaaccgtct gcaatcagtt acctaatctc caagtgctag atctgtctta caacctatta   1140

gaagatttac ccagtttttc agtctgccaa aagcttcaga aaattgacct aagacataat   1200

gaaatctacg aaattaaagt tgacactttc cagcagttgc ttagcctccg atcgctgaat   1260

ttggcttgga acaaaattgc tattattcac cccaatgcat tttccacttt gccatcccta   1320

ataaagctgg acctatcgtc caacctcctg tcgtcttttc ctataactgg gttacatggt   1380

ttaactcact taaaattaac aggaaatcat gccttacaga gcttgatatc atctgaaaac   1440

tttccagaac tcaaggttat agaaatgcct tatgcttacc agtgctgtgc atttggagtg   1500

tgtgagaatg cctataagat ttctaatcaa tggaataaag gtgacaacag cagtatggac   1560

gaccttcata agaaagatgc tggaatgttt caggctcaag atgaacgtga ccttgaagat   1620

ttcctgcttg actttgagga agacctgaaa gcccttcatt cagtgcagtg ttcaccttcc   1680

ccaggcccct tcaaaccctg tgaacacctg cttgatggct ggctgatcag aattggagtg   1740

tggaccatag cagttctggc acttacttgt aatgctttgg tgacttcaac agttttcaga   1800

tcccctctgt acatttcccc cattaaactg ttaattgggg tcatcgcagc agtgaacatg   1860

ctcacgggag tctccagtgc cgtgctggct ggtgtggatg cgttcacttt tggcagcttt   1920

gcacgacatg gtgcctggtg ggagaatggg gttggttgcc atgtcattgg ttttttgtcc   1980

atttttgctt cagaatcatc tgttttcctg cttactctgg cagccctgga gcgtgggttc   2040

tctgtgaaat attctgcaaa atttgaaacg aaagctccat tttctagcct gaaagtaatc   2100

attttgctct gtgccctgct ggccttgacc atggccgcag ttcccctgct gggtggcagc   2160

aagtatggcg cctcccctct ctgcctgcct ttgccttttg gggagcccag caccatgggc   2220

tacatggtcg ctctcatctt gctcaattcc ctttgcttcc tcatgatgac cattgcctac   2280

accaagctct actgcaattt ggacaaggga gacctggaga atatttggga ctgctctatg   2340

gtaaaacaca ttgccctgtt gctcttcacc aactgcatcc taaactgccc tgtggctttc   2400

ttgtccttct cctctttaat aaaccttaca tttatcagtc ctgaagtaat taagtttatc   2460

cttctggtgg tagtcccact tcctgcatgt ctcaatcccc ttctctacat cttgttcaat   2520

cctcacttta aggaggatct ggtgagcctg agaaagcaaa cctacgtctg gacaagatca   2580

aaacacccaa gcttgatgtc aattaactct gatgatgtcg aaaaacagtc ctgtgactca   2640

actcaagcct tggtaacctt taccagctcc agcatcactt atgacctgcc tcccagttcc   2700

gtgccatcac cagcttatcc agtgactgag agctgccatc tttcctctgt ggcatttgtc   2760

ccatgtctct aattaatatg tgaaggaaaa tgttttcaaa ggttgagaac ctgaaaatgt   2820

gagattgagt atatcagagc agtaattaat aagaagagct gaggtgaaac tcggtttaaa   2880


<210>  2
<211>  907
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asp Thr Ser Arg Leu Gly Val Leu Leu Ser Leu Pro Val Leu Leu 
1               5                   10                  15      


Gln Leu Ala Thr Gly Gly Ser Ser Pro Arg Ser Gly Val Leu Leu Arg 
            20                  25                  30          


Gly Cys Pro Thr His Cys His Cys Glu Pro Asp Gly Arg Met Leu Leu 
        35                  40                  45              


Arg Val Asp Cys Ser Asp Leu Gly Leu Ser Glu Leu Pro Ser Asn Leu 
    50                  55                  60                  


Ser Val Phe Thr Ser Tyr Leu Asp Leu Ser Met Asn Asn Ile Ser Gln 
65                  70                  75                  80  


Leu Leu Pro Asn Pro Leu Pro Ser Leu Arg Phe Leu Glu Glu Leu Arg 
                85                  90                  95      


Leu Ala Gly Asn Ala Leu Thr Tyr Ile Pro Lys Gly Ala Phe Thr Gly 
            100                 105                 110         


Leu Tyr Ser Leu Lys Val Leu Met Leu Gln Asn Asn Gln Leu Arg His 
        115                 120                 125             


Val Pro Thr Glu Ala Leu Gln Asn Leu Arg Ser Leu Gln Ser Leu Arg 
    130                 135                 140                 


Leu Asp Ala Asn His Ile Ser Tyr Val Pro Pro Ser Cys Phe Ser Gly 
145                 150                 155                 160 


Leu His Ser Leu Arg His Leu Trp Leu Asp Asp Asn Ala Leu Thr Glu 
                165                 170                 175     


Ile Pro Val Gln Ala Phe Arg Ser Leu Ser Ala Leu Gln Ala Met Thr 
            180                 185                 190         


Leu Ala Leu Asn Lys Ile His His Ile Pro Asp Tyr Ala Phe Gly Asn 
        195                 200                 205             


Leu Ser Ser Leu Val Val Leu His Leu His Asn Asn Arg Ile His Ser 
    210                 215                 220                 


Leu Gly Lys Lys Cys Phe Asp Gly Leu His Ser Leu Glu Thr Leu Asp 
225                 230                 235                 240 


Leu Asn Tyr Asn Asn Leu Asp Glu Phe Pro Thr Ala Ile Arg Thr Leu 
                245                 250                 255     


Ser Asn Leu Lys Glu Leu Gly Phe His Ser Asn Asn Ile Arg Ser Ile 
            260                 265                 270         


Pro Glu Lys Ala Phe Val Gly Asn Pro Ser Leu Ile Thr Ile His Phe 
        275                 280                 285             


Tyr Asp Asn Pro Ile Gln Phe Val Gly Arg Ser Ala Phe Gln His Leu 
    290                 295                 300                 


Pro Glu Leu Arg Thr Leu Thr Leu Asn Gly Ala Ser Gln Ile Thr Glu 
305                 310                 315                 320 


Phe Pro Asp Leu Thr Gly Thr Ala Asn Leu Glu Ser Leu Thr Leu Thr 
                325                 330                 335     


Gly Ala Gln Ile Ser Ser Leu Pro Gln Thr Val Cys Asn Gln Leu Pro 
            340                 345                 350         


Asn Leu Gln Val Leu Asp Leu Ser Tyr Asn Leu Leu Glu Asp Leu Pro 
        355                 360                 365             


Ser Phe Ser Val Cys Gln Lys Leu Gln Lys Ile Asp Leu Arg His Asn 
    370                 375                 380                 


Glu Ile Tyr Glu Ile Lys Val Asp Thr Phe Gln Gln Leu Leu Ser Leu 
385                 390                 395                 400 


Arg Ser Leu Asn Leu Ala Trp Asn Lys Ile Ala Ile Ile His Pro Asn 
                405                 410                 415     


Ala Phe Ser Thr Leu Pro Ser Leu Ile Lys Leu Asp Leu Ser Ser Asn 
            420                 425                 430         


Leu Leu Ser Ser Phe Pro Ile Thr Gly Leu His Gly Leu Thr His Leu 
        435                 440                 445             


Lys Leu Thr Gly Asn His Ala Leu Gln Ser Leu Ile Ser Ser Glu Asn 
    450                 455                 460                 


Phe Pro Glu Leu Lys Val Ile Glu Met Pro Tyr Ala Tyr Gln Cys Cys 
465                 470                 475                 480 


Ala Phe Gly Val Cys Glu Asn Ala Tyr Lys Ile Ser Asn Gln Trp Asn 
                485                 490                 495     


Lys Gly Asp Asn Ser Ser Met Asp Asp Leu His Lys Lys Asp Ala Gly 
            500                 505                 510         


Met Phe Gln Ala Gln Asp Glu Arg Asp Leu Glu Asp Phe Leu Leu Asp 
        515                 520                 525             


Phe Glu Glu Asp Leu Lys Ala Leu His Ser Val Gln Cys Ser Pro Ser 
    530                 535                 540                 


Pro Gly Pro Phe Lys Pro Cys Glu His Leu Leu Asp Gly Trp Leu Ile 
545                 550                 555                 560 


Arg Ile Gly Val Trp Thr Ile Ala Val Leu Ala Leu Thr Cys Asn Ala 
                565                 570                 575     


Leu Val Thr Ser Thr Val Phe Arg Ser Pro Leu Tyr Ile Ser Pro Ile 
            580                 585                 590         


Lys Leu Leu Ile Gly Val Ile Ala Ala Val Asn Met Leu Thr Gly Val 
        595                 600                 605             


Ser Ser Ala Val Leu Ala Gly Val Asp Ala Phe Thr Phe Gly Ser Phe 
    610                 615                 620                 


Ala Arg His Gly Ala Trp Trp Glu Asn Gly Val Gly Cys His Val Ile 
625                 630                 635                 640 


Gly Phe Leu Ser Ile Phe Ala Ser Glu Ser Ser Val Phe Leu Leu Thr 
                645                 650                 655     


Leu Ala Ala Leu Glu Arg Gly Phe Ser Val Lys Tyr Ser Ala Lys Phe 
            660                 665                 670         


Glu Thr Lys Ala Pro Phe Ser Ser Leu Lys Val Ile Ile Leu Leu Cys 
        675                 680                 685             


Ala Leu Leu Ala Leu Thr Met Ala Ala Val Pro Leu Leu Gly Gly Ser 
    690                 695                 700                 


Lys Tyr Gly Ala Ser Pro Leu Cys Leu Pro Leu Pro Phe Gly Glu Pro 
705                 710                 715                 720 


Ser Thr Met Gly Tyr Met Val Ala Leu Ile Leu Leu Asn Ser Leu Cys 
                725                 730                 735     


Phe Leu Met Met Thr Ile Ala Tyr Thr Lys Leu Tyr Cys Asn Leu Asp 
            740                 745                 750         


Lys Gly Asp Leu Glu Asn Ile Trp Asp Cys Ser Met Val Lys His Ile 
        755                 760                 765             


Ala Leu Leu Leu Phe Thr Asn Cys Ile Leu Asn Cys Pro Val Ala Phe 
    770                 775                 780                 


Leu Ser Phe Ser Ser Leu Ile Asn Leu Thr Phe Ile Ser Pro Glu Val 
785                 790                 795                 800 


Ile Lys Phe Ile Leu Leu Val Val Val Pro Leu Pro Ala Cys Leu Asn 
                805                 810                 815     


Pro Leu Leu Tyr Ile Leu Phe Asn Pro His Phe Lys Glu Asp Leu Val 
            820                 825                 830         


Ser Leu Arg Lys Gln Thr Tyr Val Trp Thr Arg Ser Lys His Pro Ser 
        835                 840                 845             


Leu Met Ser Ile Asn Ser Asp Asp Val Glu Lys Gln Ser Cys Asp Ser 
    850                 855                 860                 


Thr Gln Ala Leu Val Thr Phe Thr Ser Ser Ser Ile Thr Tyr Asp Leu 
865                 870                 875                 880 


Pro Pro Ser Ser Val Pro Ser Pro Ala Tyr Pro Val Thr Glu Ser Cys 
                885                 890                 895     


His Leu Ser Ser Val Ala Phe Val Pro Cys Leu 
            900                 905         


