                         SEQUENCE LISTING

<110>  ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
       UNIVERSITE RENE DESCARTES - PARIS 5
       UNIVERSITE PARIS-SUD 11
 
<120>  Procd de diagnostic d'une sclrodermie systmique ou d'une 
       hypertension artrielle pulmonaire

<130>  B762PC00

<160>  24    

<170>  PatentIn version 3.3

<210>  1
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
    50                  55                  60                  


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
                85                  90                  95      


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
            100                 105                 110         


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
        115                 120                 125             


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
    130                 135                 140                 


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
145                 150                 155                 160 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
                165                 170                 175     


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
            180                 185                 190         


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
        195                 200                 205             


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
    210                 215                 220                 


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
225                 230                 235                 240 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
                245                 250                 255     


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
            260                 265                 270         


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
        275                 280                 285             


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
305                 310                 315                 320 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
                325                 330                 335     


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
            340                 345                 350         


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
        355                 360                 365             


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
    370                 375                 380                 


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
385                 390                 395                 400 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
                405                 410                 415     


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
            420                 425                 430         


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
        435                 440                 445             


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
    450                 455                 460                 


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
465                 470                 475                 480 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
                485                 490                 495     


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
        515                 520                 525             


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
    530                 535                 540                 


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
545                 550                 555                 560 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
                565                 570                 575     


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
        595                 600                 605             


Leu 
    


<210>  2
<211>  572
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ala Pro Arg Pro Ser Pro Ala Ile Ser Val Ser Val Ser Ala 
1               5                   10                  15      


Pro Ala Phe Tyr Ala Pro Gln Lys Lys Phe Gly Pro Val Val Ala Pro 
            20                  25                  30          


Lys Pro Lys Val Asn Pro Phe Arg Pro Gly Asp Ser Glu Pro Pro Pro 
        35                  40                  45              


Ala Pro Gly Ala Gln Arg Ala Gln Met Gly Arg Val Gly Glu Ile Pro 
    50                  55                  60                  


Pro Pro Pro Pro Glu Asp Phe Pro Leu Pro Pro Pro Pro Leu Ala Gly 
65                  70                  75                  80  


Asp Gly Asp Asp Ala Glu Gly Ala Leu Gly Gly Ala Phe Pro Pro Pro 
                85                  90                  95      


Pro Pro Pro Ile Glu Glu Ser Phe Pro Pro Ala Pro Leu Glu Glu Glu 
            100                 105                 110         


Ile Phe Pro Ser Pro Pro Pro Pro Pro Glu Glu Glu Gly Gly Pro Glu 
        115                 120                 125             


Ala Pro Ile Pro Pro Pro Pro Gln Pro Arg Glu Lys Val Ser Ser Ile 
    130                 135                 140                 


Asp Leu Glu Ile Asp Ser Leu Ser Ser Leu Leu Asp Asp Met Thr Lys 
145                 150                 155                 160 


Asn Asp Pro Phe Lys Ala Arg Val Ser Ser Gly Tyr Val Pro Pro Pro 
                165                 170                 175     


Val Ala Thr Pro Phe Ser Ser Lys Ser Ser Thr Lys Pro Ala Ala Gly 
            180                 185                 190         


Gly Thr Ala Pro Leu Pro Pro Trp Lys Ser Pro Ser Ser Ser Gln Pro 
        195                 200                 205             


Leu Pro Gln Val Pro Ala Pro Ala Gln Ser Gln Thr Gln Phe His Val 
    210                 215                 220                 


Gln Pro Gln Pro Gln Pro Lys Pro Gln Val Gln Leu His Val Gln Ser 
225                 230                 235                 240 


Gln Thr Gln Pro Val Ser Leu Ala Asn Thr Gln Pro Arg Gly Pro Pro 
                245                 250                 255     


Ala Ser Ser Pro Ala Pro Ala Pro Lys Phe Ser Pro Val Thr Pro Lys 
            260                 265                 270         


Phe Thr Pro Val Ala Ser Lys Phe Ser Pro Gly Ala Pro Gly Gly Ser 
        275                 280                 285             


Gly Ser Gln Pro Asn Gln Lys Leu Gly His Pro Glu Ala Leu Ser Ala 
    290                 295                 300                 


Gly Thr Gly Ser Pro Gln Pro Pro Ser Phe Thr Tyr Ala Gln Gln Arg 
305                 310                 315                 320 


Glu Lys Pro Arg Val Gln Glu Lys Gln His Pro Val Pro Pro Pro Ala 
                325                 330                 335     


Gln Asn Gln Asn Gln Val Arg Ser Pro Gly Ala Pro Gly Pro Leu Thr 
            340                 345                 350         


Leu Lys Glu Val Glu Glu Leu Glu Gln Leu Thr Gln Gln Leu Met Gln 
        355                 360                 365             


Asp Met Glu His Pro Gln Arg Gln Asn Val Ala Val Asn Glu Leu Cys 
    370                 375                 380                 


Gly Arg Cys His Gln Pro Leu Ala Arg Ala Gln Pro Ala Val Arg Ala 
385                 390                 395                 400 


Leu Gly Gln Leu Phe His Ile Ala Cys Phe Thr Cys His Gln Cys Ala 
                405                 410                 415     


Gln Gln Leu Gln Gly Gln Gln Phe Tyr Ser Leu Glu Gly Ala Pro Tyr 
            420                 425                 430         


Cys Glu Gly Cys Tyr Thr Asp Thr Leu Glu Lys Cys Asn Thr Cys Gly 
        435                 440                 445             


Glu Pro Ile Thr Asp Arg Met Leu Arg Ala Thr Gly Lys Ala Tyr His 
    450                 455                 460                 


Pro His Cys Phe Thr Cys Val Val Cys Ala Arg Pro Leu Glu Gly Thr 
465                 470                 475                 480 


Ser Phe Ile Val Asp Gln Ala Asn Arg Pro His Cys Val Pro Asp Tyr 
                485                 490                 495     


His Lys Gln Tyr Ala Pro Arg Cys Ser Val Cys Ser Glu Pro Ile Met 
            500                 505                 510         


Pro Glu Pro Gly Arg Asp Glu Thr Val Arg Val Val Ala Leu Asp Lys 
        515                 520                 525             


Asn Phe His Met Lys Cys Tyr Lys Cys Glu Asp Cys Gly Lys Pro Leu 
    530                 535                 540                 


Ser Ile Glu Ala Asp Asp Asn Gly Cys Phe Pro Leu Asp Gly His Val 
545                 550                 555                 560 


Leu Cys Arg Lys Cys His Thr Ala Arg Ala Gln Thr 
                565                 570         


<210>  3
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Cys Gly Leu Val Ala Ser Asn Leu Asn Leu Lys Pro Gly Glu 
1               5                   10                  15      


Cys Leu Arg Val Arg Gly Glu Val Ala Pro Asp Ala Lys Ser Phe Val 
            20                  25                  30          


Leu Asn Leu Gly Lys Asp Ser Asn Asn Leu Cys Leu His Phe Asn Pro 
        35                  40                  45              


Arg Phe Asn Ala His Gly Asp Ala Asn Thr Ile Val Cys Asn Ser Lys 
    50                  55                  60                  


Asp Gly Gly Ala Trp Gly Thr Glu Gln Arg Glu Ala Val Phe Pro Phe 
65                  70                  75                  80  


Gln Pro Gly Ser Val Ala Glu Val Cys Ile Thr Phe Asp Gln Ala Asn 
                85                  90                  95      


Leu Thr Val Lys Leu Pro Asp Gly Tyr Glu Phe Lys Phe Pro Asn Arg 
            100                 105                 110         


Leu Asn Leu Glu Ala Ile Asn Tyr Met Ala Ala Asp Gly Asp Phe Lys 
        115                 120                 125             


Ile Lys Cys Val Ala Phe Asp 
    130                 135 


<210>  4
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gln Leu Lys Pro Met Glu Ile Asn Pro Glu Met Leu Asn Lys Val 
1               5                   10                  15      


Leu Ser Arg Leu Gly Val Ala Gly Gln Trp Arg Phe Val Asp Val Leu 
            20                  25                  30          


Gly Leu Glu Glu Glu Ser Leu Gly Ser Val Pro Ala Pro Ala Cys Ala 
        35                  40                  45              


Leu Leu Leu Leu Phe Pro Leu Thr Ala Gln His Glu Asn Phe Arg Lys 
    50                  55                  60                  


Lys Gln Ile Glu Glu Leu Lys Gly Gln Glu Val Ser Pro Lys Val Tyr 
65                  70                  75                  80  


Phe Met Lys Gln Thr Ile Gly Asn Ser Cys Gly Thr Ile Gly Leu Ile 
                85                  90                  95      


His Ala Val Ala Asn Asn Gln Asp Lys Leu Gly Phe Glu Asp Gly Ser 
            100                 105                 110         


Val Leu Lys Gln Phe Leu Ser Glu Thr Glu Lys Met Ser Pro Glu Asp 
        115                 120                 125             


Arg Ala Lys Cys Phe Glu Lys Asn Glu Ala Ile Gln Ala Ala His Asp 
    130                 135                 140                 


Ala Val Ala Gln Glu Gly Gln Cys Arg Val Asp Asp Lys Val Asn Phe 
145                 150                 155                 160 


His Phe Ile Leu Phe Asn Asn Val Asp Gly His Leu Tyr Glu Leu Asp 
                165                 170                 175     


Gly Arg Met Pro Phe Pro Val Asn His Gly Ala Ser Ser Glu Asp Thr 
            180                 185                 190         


Leu Leu Lys Asp Ala Ala Lys Val Cys Arg Glu Phe Thr Glu Arg Glu 
        195                 200                 205             


Gln Gly Glu Val Arg Phe Ser Ala Val Ala Leu Cys Lys Ala Ala 
    210                 215                 220             


<210>  5
<211>  793
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Asp Asp Phe Glu Arg Arg Arg Glu Leu Arg Arg Gln Lys Arg Glu 
1               5                   10                  15      


Glu Met Arg Leu Glu Ala Glu Arg Ile Ala Tyr Gln Arg Asn Asp Asp 
            20                  25                  30          


Asp Glu Glu Glu Ala Ala Arg Glu Arg Arg Arg Arg Ala Arg Gln Glu 
        35                  40                  45              


Arg Leu Arg Gln Lys Gln Glu Glu Glu Ser Leu Gly Gln Val Thr Asp 
    50                  55                  60                  


Gln Val Glu Val Asn Ala Gln Asn Ser Val Pro Asp Glu Glu Ala Lys 
65                  70                  75                  80  


Thr Thr Thr Thr Asn Thr Gln Val Glu Gly Asp Asp Glu Ala Ala Phe 
                85                  90                  95      


Leu Glu Arg Leu Ala Arg Arg Glu Glu Arg Arg Gln Lys Arg Leu Gln 
            100                 105                 110         


Glu Ala Leu Glu Arg Gln Lys Glu Phe Asp Pro Thr Ile Thr Asp Ala 
        115                 120                 125             


Ser Leu Ser Leu Pro Ser Arg Arg Met Gln Asn Asp Thr Ala Glu Asn 
    130                 135                 140                 


Glu Thr Thr Glu Lys Glu Glu Lys Ser Glu Ser Arg Gln Glu Arg Tyr 
145                 150                 155                 160 


Glu Ile Glu Glu Thr Glu Thr Val Thr Lys Ser Tyr Gln Lys Asn Asp 
                165                 170                 175     


Trp Arg Asp Ala Glu Glu Asn Lys Lys Glu Asp Lys Glu Lys Glu Glu 
            180                 185                 190         


Glu Glu Glu Glu Lys Pro Lys Arg Gly Ser Ile Gly Glu Asn Gln Val 
        195                 200                 205             


Glu Val Met Val Glu Glu Lys Thr Thr Glu Ser Gln Glu Glu Thr Val 
    210                 215                 220                 


Val Met Ser Leu Lys Asn Gly Gln Ile Ser Ser Glu Glu Pro Lys Gln 
225                 230                 235                 240 


Glu Glu Glu Arg Glu Gln Gly Ser Asp Glu Ile Ser His His Glu Lys 
                245                 250                 255     


Met Glu Glu Glu Asp Lys Glu Arg Ala Glu Ala Glu Arg Ala Arg Leu 
            260                 265                 270         


Glu Ala Glu Glu Arg Glu Arg Ile Lys Ala Glu Gln Asp Lys Lys Ile 
        275                 280                 285             


Ala Asp Glu Arg Ala Arg Ile Glu Ala Glu Glu Lys Ala Ala Ala Gln 
    290                 295                 300                 


Glu Arg Glu Arg Arg Glu Ala Glu Glu Arg Glu Arg Met Arg Glu Glu 
305                 310                 315                 320 


Glu Lys Arg Ala Ala Glu Glu Arg Gln Arg Ile Lys Glu Glu Glu Lys 
                325                 330                 335     


Arg Ala Ala Glu Glu Arg Gln Arg Ile Lys Glu Glu Glu Lys Arg Ala 
            340                 345                 350         


Ala Glu Glu Arg Gln Arg Ile Lys Glu Glu Glu Lys Arg Ala Ala Glu 
        355                 360                 365             


Glu Arg Gln Arg Ala Arg Ala Glu Glu Glu Glu Lys Ala Lys Val Glu 
    370                 375                 380                 


Glu Gln Lys Arg Asn Lys Gln Leu Glu Glu Lys Lys Arg Ala Met Gln 
385                 390                 395                 400 


Glu Thr Lys Ile Lys Gly Glu Lys Val Glu Gln Lys Ile Glu Gly Lys 
                405                 410                 415     


Trp Val Asn Glu Lys Lys Ala Gln Glu Asp Lys Leu Gln Thr Ala Val 
            420                 425                 430         


Leu Lys Lys Gln Gly Glu Glu Lys Gly Thr Lys Val Gln Ala Lys Arg 
        435                 440                 445             


Glu Lys Leu Gln Glu Asp Lys Pro Thr Phe Lys Lys Glu Glu Ile Lys 
    450                 455                 460                 


Asp Glu Lys Ile Lys Lys Asp Lys Glu Pro Lys Glu Glu Val Lys Ser 
465                 470                 475                 480 


Phe Met Asp Arg Lys Lys Gly Phe Thr Glu Val Lys Ser Gln Asn Gly 
                485                 490                 495     


Glu Phe Met Thr His Lys Leu Lys His Thr Glu Asn Thr Phe Ser Arg 
            500                 505                 510         


Pro Gly Gly Arg Ala Ser Val Asp Thr Lys Glu Ala Glu Gly Ala Pro 
        515                 520                 525             


Gln Val Glu Ala Gly Lys Arg Leu Glu Glu Leu Arg Arg Arg Arg Gly 
    530                 535                 540                 


Glu Thr Glu Ser Glu Glu Phe Glu Lys Leu Lys Gln Lys Gln Gln Glu 
545                 550                 555                 560 


Ala Ala Leu Glu Leu Glu Glu Leu Lys Lys Lys Arg Glu Glu Arg Arg 
                565                 570                 575     


Lys Val Leu Glu Glu Glu Glu Gln Arg Arg Lys Gln Glu Glu Ala Asp 
            580                 585                 590         


Arg Lys Leu Arg Glu Glu Glu Glu Lys Arg Arg Leu Lys Glu Glu Ile 
        595                 600                 605             


Glu Arg Arg Arg Ala Glu Ala Ala Glu Lys Arg Gln Lys Met Pro Glu 
    610                 615                 620                 


Asp Gly Leu Ser Asp Asp Lys Lys Pro Phe Lys Cys Phe Thr Pro Lys 
625                 630                 635                 640 


Gly Ser Ser Leu Lys Ile Glu Glu Arg Ala Glu Phe Leu Asn Lys Ser 
                645                 650                 655     


Val Gln Lys Ser Ser Gly Val Lys Ser Thr His Gln Ala Ala Ile Val 
            660                 665                 670         


Ser Lys Ile Asp Ser Arg Leu Glu Gln Tyr Thr Ser Ala Ile Glu Gly 
        675                 680                 685             


Thr Lys Ser Ala Lys Pro Thr Lys Pro Ala Ala Ser Asp Leu Pro Val 
    690                 695                 700                 


Pro Ala Glu Gly Val Arg Asn Ile Lys Ser Met Trp Glu Lys Gly Asn 
705                 710                 715                 720 


Val Phe Ser Ser Pro Thr Ala Ala Gly Thr Pro Asn Lys Glu Thr Ala 
                725                 730                 735     


Gly Leu Lys Val Gly Val Ser Ser Arg Ile Asn Glu Trp Leu Thr Lys 
            740                 745                 750         


Thr Pro Asp Gly Asn Lys Ser Pro Ala Pro Lys Pro Ser Asp Leu Arg 
        755                 760                 765             


Pro Gly Asp Val Ser Ser Lys Arg Asn Leu Trp Glu Lys Gln Ser Val 
    770                 775                 780                 


Asp Lys Val Thr Ser Pro Thr Lys Val 
785                 790             


<210>  6
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asp Pro Arg Lys Val Asn Glu Leu Arg Ala Phe Val Lys Met Cys 
1               5                   10                  15      


Lys Lys Asp Pro Ser Ile Leu His Thr Gln Glu Met Arg Phe Leu Arg 
            20                  25                  30          


Glu Trp Val Glu Ser Met Gly Gly Thr Ala Thr Gln Lys Ala Lys Ser 
        35                  40                  45              


Glu Glu Asn Thr Lys Glu Glu Lys Pro Asp Ser Lys Val Glu Glu Asp 
    50                  55                  60                  


Leu Lys Ala Asp Glu Pro Ser Ser Glu Glu Ser Asp Leu Glu Ile Asp 
65                  70                  75                  80  


Lys Glu Gly Val Ile Glu Pro Asp Thr Asp Ala Pro Gln Glu Met Gly 
                85                  90                  95      


Asp Glu Asn Ala Glu Ile Thr Glu Glu Val Met Asp Gln Ala Asn Asp 
            100                 105                 110         


Lys Lys Val Ala Ala Ile Glu Ala Leu Asn Asp Gly Glu Leu Gln Lys 
        115                 120                 125             


Ala Ile Asp Leu Phe Thr Asp Ala Ile Lys Leu Asn Pro Arg Leu Ala 
    130                 135                 140                 


Ile Leu Tyr Ala Lys Arg Ala Ser Val Phe Val Lys Leu Gln Lys Pro 
145                 150                 155                 160 


Asn Ala Ala Ile Arg Asp Cys Asp Arg Ala Ile Glu Ile Asn Pro Asp 
                165                 170                 175     


Ser Ala Gln Pro Tyr Lys Arg Arg Gly Lys Ala His Arg Leu Leu Gly 
            180                 185                 190         


His Trp Glu Glu Ala Ala His Asp Leu Ala Leu Ala Cys Lys Phe Asp 
        195                 200                 205             


Tyr Asp Glu Asp Ala Ser Ala Met Leu Lys Glu Val Gln Pro Arg Ala 
    210                 215                 220                 


Gln Lys Ile Ala Glu His Gln Arg Lys Tyr Glu Arg Lys Arg Glu Glu 
225                 230                 235                 240 


<210>  7
<211>  710
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ser Asp Tyr Ser Thr Gly Gly Pro Pro Pro Gly Pro Pro Pro Pro 
1               5                   10                  15      


Ala Gly Gly Gly Gly Gly Ala Gly Gly Ala Gly Gly Gly Pro Pro Pro 
            20                  25                  30          


Gly Pro Pro Gly Ala Gly Asp Arg Gly Gly Gly Gly Pro Cys Gly Gly 
        35                  40                  45              


Gly Pro Gly Gly Gly Ser Ala Gly Gly Pro Ser Gln Pro Pro Gly Gly 
    50                  55                  60                  


Gly Gly Pro Gly Ile Arg Lys Asp Ala Phe Ala Asp Ala Val Gln Arg 
65                  70                  75                  80  


Ala Arg Gln Ile Ala Ala Lys Ile Gly Gly Asp Ala Ala Thr Thr Val 
                85                  90                  95      


Asn Asn Ser Thr Pro Asp Phe Gly Phe Gly Gly Gln Lys Arg Gln Leu 
            100                 105                 110         


Glu Asp Gly Asp Gln Pro Glu Ser Lys Lys Leu Ala Ser Gln Gly Asp 
        115                 120                 125             


Ser Ile Ser Ser Gln Leu Gly Pro Ile His Pro Pro Pro Arg Thr Ser 
    130                 135                 140                 


Met Thr Glu Glu Tyr Arg Val Pro Asp Gly Met Val Gly Leu Ile Ile 
145                 150                 155                 160 


Gly Arg Gly Gly Glu Gln Ile Asn Lys Ile Gln Gln Asp Ser Gly Cys 
                165                 170                 175     


Lys Val Gln Ile Ser Pro Asp Ser Gly Gly Leu Pro Glu Arg Ser Val 
            180                 185                 190         


Ser Leu Thr Gly Ala Pro Glu Ser Val Gln Lys Ala Lys Met Met Leu 
        195                 200                 205             


Asp Asp Ile Val Ser Arg Gly Arg Gly Gly Pro Pro Gly Gln Phe His 
    210                 215                 220                 


Asp Asn Ala Asn Gly Gly Gln Asn Gly Thr Val Gln Glu Ile Met Ile 
225                 230                 235                 240 


Pro Ala Gly Lys Ala Gly Leu Val Ile Gly Lys Gly Gly Glu Thr Ile 
                245                 250                 255     


Lys Gln Leu Gln Glu Arg Ala Gly Val Lys Met Ile Leu Ile Gln Asp 
            260                 265                 270         


Gly Ser Gln Asn Thr Asn Val Asp Lys Pro Leu Arg Ile Ile Gly Asp 
        275                 280                 285             


Pro Tyr Lys Val Gln Gln Ala Cys Glu Met Val Met Asp Ile Leu Arg 
    290                 295                 300                 


Glu Arg Asp Gln Gly Gly Phe Gly Asp Arg Asn Glu Tyr Gly Ser Arg 
305                 310                 315                 320 


Ile Gly Gly Gly Ile Asp Val Pro Val Pro Arg His Ser Val Gly Val 
                325                 330                 335     


Val Ile Gly Arg Ser Gly Glu Met Ile Lys Lys Ile Gln Asn Asp Ala 
            340                 345                 350         


Gly Val Arg Ile Gln Phe Lys Gln Asp Asp Gly Thr Gly Pro Glu Lys 
        355                 360                 365             


Ile Ala His Ile Met Gly Pro Pro Asp Arg Cys Glu His Ala Ala Arg 
    370                 375                 380                 


Ile Ile Asn Asp Leu Leu Gln Ser Leu Arg Ser Gly Pro Pro Gly Pro 
385                 390                 395                 400 


Pro Gly Gly Pro Gly Met Pro Pro Gly Gly Arg Gly Arg Gly Arg Gly 
                405                 410                 415     


Gln Gly Asn Trp Gly Pro Pro Gly Gly Glu Met Thr Phe Ser Ile Pro 
            420                 425                 430         


Thr His Lys Cys Gly Leu Val Ile Gly Arg Gly Gly Glu Asn Val Lys 
        435                 440                 445             


Ala Ile Asn Gln Gln Thr Gly Ala Phe Val Glu Ile Ser Arg Gln Leu 
    450                 455                 460                 


Pro Pro Asn Gly Asp Pro Asn Phe Lys Leu Phe Ile Ile Arg Gly Ser 
465                 470                 475                 480 


Pro Gln Gln Ile Asp His Ala Lys Gln Leu Ile Glu Glu Lys Ile Glu 
                485                 490                 495     


Gly Pro Leu Cys Pro Val Gly Pro Gly Pro Gly Gly Pro Gly Pro Ala 
            500                 505                 510         


Gly Pro Met Gly Pro Phe Asn Pro Gly Pro Phe Asn Gln Gly Pro Pro 
        515                 520                 525             


Gly Ala Pro Pro His Ala Gly Gly Pro Pro Pro His Gln Tyr Pro Pro 
    530                 535                 540                 


Gln Gly Trp Gly Asn Thr Tyr Pro Gln Trp Gln Pro Pro Ala Pro His 
545                 550                 555                 560 


Asp Pro Ser Lys Ala Ala Ala Ala Ala Ala Asp Pro Asn Ala Ala Trp 
                565                 570                 575     


Ala Ala Tyr Tyr Ser His Tyr Tyr Gln Gln Pro Pro Gly Pro Val Pro 
            580                 585                 590         


Gly Pro Ala Pro Ala Pro Ala Ala Pro Pro Ala Gln Gly Glu Pro Pro 
        595                 600                 605             


Gln Pro Pro Pro Thr Gly Gln Ser Asp Tyr Thr Lys Ala Trp Glu Glu 
    610                 615                 620                 


Tyr Tyr Lys Lys Ile Gly Gln Gln Pro Gln Gln Pro Gly Ala Pro Pro 
625                 630                 635                 640 


Gln Gln Asp Tyr Thr Lys Ala Trp Glu Glu Tyr Tyr Lys Lys Gln Ala 
                645                 650                 655     


Gln Val Ala Thr Gly Gly Gly Pro Gly Ala Pro Pro Gly Ser Gln Pro 
            660                 665                 670         


Asp Tyr Ser Ala Ala Trp Ala Glu Tyr Tyr Arg Gln Gln Ala Ala Tyr 
        675                 680                 685             


Tyr Gly Gln Thr Pro Val Pro Gly Pro Gln Pro Pro Pro Thr Gln Gln 
    690                 695                 700                 


Gly Gln Gln Gln Ala Gln 
705                 710 


<210>  8
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Glu Glu Glu Ile Ala Ala Leu Val Ile Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              


Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  


Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Val Thr Asn Trp Asp 
65                  70                  75                  80  


Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      


Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn Pro 
            100                 105                 110         


Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn 
        115                 120                 125             


Thr Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala 
    130                 135                 140                 


Ser Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr 
145                 150                 155                 160 


His Thr Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala Ile Leu 
                165                 170                 175     


Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met Lys Ile 
            180                 185                 190         


Leu Thr Glu Arg Gly Tyr Ser Phe Thr Thr Thr Ala Glu Arg Glu Ile 
        195                 200                 205             


Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe Glu 
    210                 215                 220                 


Gln Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys Ser Tyr 
225                 230                 235                 240 


Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe Arg 
                245                 250                 255     


Cys Pro Glu Ala Leu Phe Gln Pro Ser Phe Leu Gly Met Glu Ser Cys 
            260                 265                 270         


Gly Ile His Glu Thr Thr Phe Asn Ser Ile Met Lys Cys Asp Val Asp 
        275                 280                 285             


Ile Arg Lys Asp Leu Tyr Ala Asn Thr Val Leu Ser Gly Gly Thr Thr 
    290                 295                 300                 


Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr Ala Leu 
305                 310                 315                 320 


Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu Arg Lys 
                325                 330                 335     


Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser Thr Phe 
            340                 345                 350         


Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser 
        355                 360                 365             


Ile Val His Arg Lys Cys Phe 
    370                 375 


<210>  9
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ser Ile Glu Lys Ile Trp Ala Arg Glu Ile Leu Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu Tyr Thr Ala Lys Gly Leu Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Gly Asp Lys Gln Arg Tyr Leu Gly Lys Gly Val Leu Lys 
    50                  55                  60                  


Ala Val Asp His Ile Asn Ser Thr Ile Ala Pro Ala Leu Ile Ser Ser 
65                  70                  75                  80  


Gly Leu Ser Val Val Glu Gln Glu Lys Leu Asp Asn Leu Met Leu Glu 
                85                  90                  95      


Leu Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Ala Glu Arg Glu Leu 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Gln Leu Ala Gly Asn Ser Asp Leu Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Glu 
                165                 170                 175     


Ser Phe Arg Asp Ala Met Arg Leu Gly Ala Glu Val Tyr His Thr Leu 
            180                 185                 190         


Lys Gly Val Ile Lys Asp Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Ser Glu Ala Leu 
    210                 215                 220                 


Glu Leu Val Lys Glu Ala Ile Asp Lys Ala Gly Tyr Thr Glu Lys Ile 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Tyr Arg Asp Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Thr Asp Pro Ser Arg Tyr Ile Thr 
            260                 265                 270         


Gly Asp Gln Leu Gly Ala Leu Tyr Gln Asp Phe Val Arg Asp Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Ala Ala Trp 
    290                 295                 300                 


Ser Lys Phe Thr Ala Asn Val Gly Ile Gln Ile Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Glu Arg Ala Val Glu Glu Lys Ala 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ala Ile Gln Ala Cys Lys Leu Ala Gln Glu Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Met Arg Ile Glu Glu Glu 
                405                 410                 415     


Leu Gly Asp Glu Ala Arg Phe Ala Gly His Asn Phe Arg Asn Pro Ser 
            420                 425                 430         


Val Leu 
        


<210>  10
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Arg Leu Arg Arg Leu Ala Leu Phe Pro Gly Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Arg Leu Ala Ala Ala Ser Asp Val Leu Glu Leu Thr Asp 
            20                  25                  30          


Asp Asn Phe Glu Ser Arg Ile Ser Asp Thr Gly Ser Ala Gly Leu Met 
        35                  40                  45              


Leu Val Glu Phe Phe Ala Pro Trp Cys Gly His Cys Lys Arg Leu Ala 
    50                  55                  60                  


Pro Glu Tyr Glu Ala Ala Ala Thr Arg Leu Lys Gly Ile Val Pro Leu 
65                  70                  75                  80  


Ala Lys Val Asp Cys Thr Ala Asn Thr Asn Thr Cys Asn Lys Tyr Gly 
                85                  90                  95      


Val Ser Gly Tyr Pro Thr Leu Lys Ile Phe Arg Asp Gly Glu Glu Ala 
            100                 105                 110         


Gly Ala Tyr Asp Gly Pro Arg Thr Ala Asp Gly Ile Val Ser His Leu 
        115                 120                 125             


Lys Lys Gln Ala Gly Pro Ala Ser Val Pro Leu Arg Thr Glu Glu Glu 
    130                 135                 140                 


Phe Lys Lys Phe Ile Ser Asp Lys Asp Ala Ser Ile Val Gly Phe Phe 
145                 150                 155                 160 


Asp Asp Ser Phe Ser Glu Ala His Ser Glu Phe Leu Lys Ala Ala Ser 
                165                 170                 175     


Asn Leu Arg Asp Asn Tyr Arg Phe Ala His Thr Asn Val Glu Ser Leu 
            180                 185                 190         


Val Asn Glu Tyr Asp Asp Asn Gly Glu Gly Ile Ile Leu Phe Arg Pro 
        195                 200                 205             


Ser His Leu Thr Asn Lys Phe Glu Asp Lys Thr Val Ala Tyr Thr Glu 
    210                 215                 220                 


Gln Lys Met Thr Ser Gly Lys Ile Lys Lys Phe Ile Gln Glu Asn Ile 
225                 230                 235                 240 


Phe Gly Ile Cys Pro His Met Thr Glu Asp Asn Lys Asp Leu Ile Gln 
                245                 250                 255     


Gly Lys Asp Leu Leu Ile Ala Tyr Tyr Asp Val Asp Tyr Glu Lys Asn 
            260                 265                 270         


Ala Lys Gly Ser Asn Tyr Trp Arg Asn Arg Val Met Met Val Ala Lys 
        275                 280                 285             


Lys Phe Leu Asp Ala Gly His Lys Leu Asn Phe Ala Val Ala Ser Arg 
    290                 295                 300                 


Lys Thr Phe Ser His Glu Leu Ser Asp Phe Gly Leu Glu Ser Thr Ala 
305                 310                 315                 320 


Gly Glu Ile Pro Val Val Ala Ile Arg Thr Ala Lys Gly Glu Lys Phe 
                325                 330                 335     


Val Met Gln Glu Glu Phe Ser Arg Asp Gly Lys Ala Leu Glu Arg Phe 
            340                 345                 350         


Leu Gln Asp Tyr Phe Asp Gly Asn Leu Lys Arg Tyr Leu Lys Ser Glu 
        355                 360                 365             


Pro Ile Pro Glu Ser Asn Asp Gly Pro Val Lys Val Val Val Ala Glu 
    370                 375                 380                 


Asn Phe Asp Glu Ile Val Asn Asn Glu Asn Lys Asp Val Leu Ile Glu 
385                 390                 395                 400 


Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Asn Leu Glu Pro Lys Tyr 
                405                 410                 415     


Lys Glu Leu Gly Glu Lys Leu Ser Lys Asp Pro Asn Ile Val Ile Ala 
            420                 425                 430         


Lys Met Asp Ala Thr Ala Asn Asp Val Pro Ser Pro Tyr Glu Val Arg 
        435                 440                 445             


Gly Phe Pro Thr Ile Tyr Phe Ser Pro Ala Asn Lys Lys Leu Asn Pro 
    450                 455                 460                 


Lys Lys Tyr Glu Gly Gly Arg Glu Leu Ser Asp Phe Ile Ser Tyr Leu 
465                 470                 475                 480 


Gln Arg Glu Ala Thr Asn Pro Pro Val Ile Gln Glu Glu Lys Pro Lys 
                485                 490                 495     


Lys Lys Lys Lys Ala Gln Glu Asp Leu 
            500                 505 


<210>  11
<211>  470
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ser Gln Ala Tyr Ser Ser Ser Gln Arg Val Ser Ser Tyr Arg Arg 
1               5                   10                  15      


Thr Phe Gly Gly Ala Pro Gly Phe Pro Leu Gly Ser Pro Leu Ser Ser 
            20                  25                  30          


Pro Val Phe Pro Arg Ala Gly Phe Gly Ser Lys Gly Ser Ser Ser Ser 
        35                  40                  45              


Val Thr Ser Arg Val Tyr Gln Val Ser Arg Thr Ser Gly Gly Ala Gly 
    50                  55                  60                  


Gly Leu Gly Ser Leu Arg Ala Ser Arg Leu Gly Thr Thr Arg Thr Pro 
65                  70                  75                  80  


Ser Ser Tyr Gly Ala Gly Glu Leu Leu Asp Phe Ser Leu Ala Asp Ala 
                85                  90                  95      


Val Asn Gln Glu Phe Leu Thr Thr Arg Thr Asn Glu Lys Val Glu Leu 
            100                 105                 110         


Gln Glu Leu Asn Asp Arg Phe Ala Asn Tyr Ile Glu Lys Val Arg Phe 
        115                 120                 125             


Leu Glu Gln Gln Asn Ala Ala Leu Ala Ala Glu Val Asn Arg Leu Lys 
    130                 135                 140                 


Gly Arg Glu Pro Thr Arg Val Ala Glu Leu Tyr Glu Glu Glu Leu Arg 
145                 150                 155                 160 


Glu Leu Arg Arg Gln Val Glu Val Leu Thr Asn Gln Arg Ala Arg Val 
                165                 170                 175     


Asp Val Glu Arg Asp Asn Leu Leu Asp Asp Leu Gln Arg Leu Lys Ala 
            180                 185                 190         


Lys Leu Gln Glu Glu Ile Gln Leu Lys Glu Glu Ala Glu Asn Asn Leu 
        195                 200                 205             


Ala Ala Phe Arg Ala Asp Val Asp Ala Ala Thr Leu Ala Arg Ile Asp 
    210                 215                 220                 


Leu Glu Arg Arg Ile Glu Ser Leu Asn Glu Glu Ile Ala Phe Leu Lys 
225                 230                 235                 240 


Lys Val His Glu Glu Glu Ile Arg Glu Leu Gln Ala Gln Leu Gln Glu 
                245                 250                 255     


Gln Gln Val Gln Val Glu Met Asp Met Ser Lys Pro Asp Leu Thr Ala 
            260                 265                 270         


Ala Leu Arg Asp Ile Arg Ala Gln Tyr Glu Thr Ile Ala Ala Lys Asn 
        275                 280                 285             


Ile Ser Glu Ala Glu Glu Trp Tyr Lys Ser Lys Val Ser Asp Leu Thr 
    290                 295                 300                 


Gln Ala Ala Asn Lys Asn Asn Asp Ala Leu Arg Gln Ala Lys Gln Glu 
305                 310                 315                 320 


Met Met Glu Tyr Arg His Gln Ile Gln Ser Tyr Thr Cys Glu Ile Asp 
                325                 330                 335     


Ala Leu Lys Gly Thr Asn Asp Ser Leu Met Arg Gln Met Arg Glu Leu 
            340                 345                 350         


Glu Asp Arg Phe Ala Ser Glu Ala Ser Gly Tyr Gln Asp Asn Ile Ala 
        355                 360                 365             


Arg Leu Glu Glu Glu Ile Arg His Leu Lys Asp Glu Met Ala Arg His 
    370                 375                 380                 


Leu Arg Glu Tyr Gln Asp Leu Leu Asn Val Lys Met Ala Leu Asp Val 
385                 390                 395                 400 


Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu Gly Glu Glu Ser Arg Ile 
                405                 410                 415     


Asn Leu Pro Ile Gln Thr Tyr Ser Ala Leu Asn Phe Arg Glu Thr Ser 
            420                 425                 430         


Pro Glu Gln Arg Gly Ser Glu Val His Thr Lys Lys Thr Val Met Ile 
        435                 440                 445             


Lys Thr Ile Glu Thr Arg Asp Gly Glu Val Val Ser Glu Ala Thr Gln 
    450                 455                 460                 


Gln Gln His Glu Val Leu 
465                 470 


<210>  12
<211>  470
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ser His His Pro Ser Gly Leu Arg Ala Gly Phe Ser Ser Thr Ser 
1               5                   10                  15      


Tyr Arg Arg Thr Phe Gly Pro Pro Pro Ser Leu Ser Pro Gly Ala Phe 
            20                  25                  30          


Ser Tyr Ser Ser Ser Ser Arg Phe Ser Ser Ser Arg Leu Leu Gly Ser 
        35                  40                  45              


Ala Ser Pro Ser Ser Ser Val Arg Leu Gly Ser Phe Arg Ser Pro Arg 
    50                  55                  60                  


Ala Gly Ala Gly Ala Leu Leu Arg Leu Pro Ser Glu Arg Leu Asp Phe 
65                  70                  75                  80  


Ser Met Ala Glu Ala Leu Asn Gln Glu Phe Leu Ala Thr Arg Ser Asn 
                85                  90                  95      


Glu Lys Gln Glu Leu Gln Glu Leu Asn Asp Arg Phe Ala Asn Phe Ile 
            100                 105                 110         


Glu Lys Val Arg Phe Leu Glu Gln Gln Asn Ala Ala Leu Arg Gly Glu 
        115                 120                 125             


Leu Ser Gln Ala Arg Gly Gln Glu Pro Ala Arg Ala Asp Gln Leu Cys 
    130                 135                 140                 


Gln Gln Glu Leu Arg Glu Leu Arg Arg Glu Leu Glu Leu Leu Gly Arg 
145                 150                 155                 160 


Glu Arg Asp Arg Val Gln Val Glu Arg Asp Gly Leu Ala Glu Asp Leu 
                165                 170                 175     


Ala Ala Leu Lys Gln Arg Leu Glu Glu Glu Thr Arg Lys Arg Glu Asp 
            180                 185                 190         


Ala Glu His Asn Leu Val Leu Phe Arg Lys Asp Val Asp Asp Ala Thr 
        195                 200                 205             


Leu Ser Arg Leu Glu Leu Glu Arg Lys Ile Glu Ser Leu Met Asp Glu 
    210                 215                 220                 


Ile Glu Phe Leu Lys Lys Leu His Glu Glu Glu Leu Arg Asp Leu Gln 
225                 230                 235                 240 


Val Ser Val Glu Ser Gln Gln Val Gln Gln Val Glu Val Glu Ala Thr 
                245                 250                 255     


Val Lys Pro Glu Leu Thr Ala Ala Leu Arg Asp Ile Arg Ala Gln Tyr 
            260                 265                 270         


Glu Ser Ile Ala Ala Lys Asn Leu Gln Glu Ala Glu Glu Trp Tyr Lys 
        275                 280                 285             


Ser Lys Tyr Ala Asp Leu Ser Asp Ala Ala Asn Arg Asn His Glu Ala 
    290                 295                 300                 


Leu Arg Gln Ala Lys Gln Glu Met Asn Glu Ser Arg Arg Gln Ile Gln 
305                 310                 315                 320 


Ser Leu Thr Cys Glu Val Asp Gly Leu Arg Gly Thr Asn Glu Ala Leu 
                325                 330                 335     


Leu Arg Gln Leu Arg Glu Leu Glu Glu Gln Phe Ala Leu Glu Ala Gly 
            340                 345                 350         


Gly Tyr Gln Ala Gly Ala Ala Arg Leu Glu Glu Glu Leu Arg Gln Leu 
        355                 360                 365             


Lys Glu Glu Met Ala Arg His Leu Arg Glu Tyr Gln Glu Leu Leu Asn 
    370                 375                 380                 


Val Lys Met Ala Leu Asp Ile Glu Ile Ala Thr Tyr Arg Lys Leu Leu 
385                 390                 395                 400 


Glu Gly Glu Glu Ser Arg Ile Ser Val Pro Val His Ser Phe Ala Ser 
                405                 410                 415     


Leu Asn Ile Lys Thr Thr Val Pro Glu Val Glu Pro Pro Gln Asp Ser 
            420                 425                 430         


His Ser Arg Lys Thr Val Leu Ile Lys Thr Ile Glu Thr Arg Asn Gly 
        435                 440                 445             


Glu Val Val Thr Glu Ser Gln Lys Glu Gln Arg Ser Glu Leu Asp Lys 
    450                 455                 460                 


Ser Ser Ala His Ser Tyr 
465                 470 


<210>  13
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Met Leu Gly Thr Glu Gly Gly Glu Gly Phe Val Val Lys Val Arg 
1               5                   10                  15      


Gly Leu Pro Trp Ser Cys Ser Ala Asp Glu Val Gln Arg Phe Phe Ser 
            20                  25                  30          


Asp Cys Lys Ile Gln Asn Gly Ala Gln Gly Ile Arg Phe Ile Tyr Thr 
        35                  40                  45              


Arg Glu Gly Arg Pro Ser Gly Glu Ala Phe Val Glu Leu Glu Ser Glu 
    50                  55                  60                  


Asp Glu Val Lys Leu Ala Leu Lys Lys Asp Arg Glu Thr Met Gly His 
65                  70                  75                  80  


Arg Tyr Val Glu Val Phe Lys Ser Asn Asn Val Glu Met Asp Trp Val 
                85                  90                  95      


Leu Lys His Thr Gly Pro Asn Ser Pro Asp Thr Ala Asn Asp Gly Phe 
            100                 105                 110         


Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Ser Lys Glu Glu Ile Val 
        115                 120                 125             


Gln Phe Phe Ser Gly Leu Glu Ile Val Pro Asn Gly Ile Thr Leu Pro 
    130                 135                 140                 


Val Asp Phe Gln Gly Arg Ser Thr Gly Glu Ala Phe Val Gln Phe Ala 
145                 150                 155                 160 


Ser Gln Glu Ile Ala Glu Lys Ala Leu Lys Lys His Lys Glu Arg Ile 
                165                 170                 175     


Gly His Arg Tyr Ile Glu Ile Phe Lys Ser Ser Arg Ala Glu Val Arg 
            180                 185                 190         


Thr His Tyr Asp Pro Pro Arg Lys Leu Met Ala Met Gln Arg Pro Gly 
        195                 200                 205             


Pro Tyr Asp Arg Pro Gly Ala Gly Arg Gly Tyr Asn Ser Ile Gly Arg 
    210                 215                 220                 


Gly Ala Gly Phe Glu Arg Met Arg Arg Gly Ala Tyr Gly Gly Gly Tyr 
225                 230                 235                 240 


Gly Gly Tyr Asp Asp Tyr Asn Gly Tyr Asn Asp Gly Tyr Gly Phe Gly 
                245                 250                 255     


Ser Asp Arg Phe Gly Arg Asp Leu Asn Tyr Cys Phe Ser Gly Met Ser 
            260                 265                 270         


Asp His Arg Tyr Gly Asp Gly Gly Ser Thr Phe Gln Ser Thr Thr Gly 
        275                 280                 285             


His Cys Val His Met Arg Gly Leu Pro Tyr Arg Ala Thr Glu Asn Asp 
    290                 295                 300                 


Ile Tyr Asn Phe Phe Ser Pro Leu Asn Pro Val Arg Val His Ile Glu 
305                 310                 315                 320 


Ile Gly Pro Asp Gly Arg Val Thr Gly Glu Ala Asp Val Glu Phe Ala 
                325                 330                 335     


Thr His Glu Asp Ala Val Ala Ala Met Ser Lys Asp Lys Ala Asn Met 
            340                 345                 350         


Gln His Arg Tyr Val Glu Leu Phe Leu Asn Ser Thr Ala Gly Ala Ser 
        355                 360                 365             


Gly Gly Ala Tyr Glu His Arg Tyr Val Glu Leu Phe Leu Asn Ser Thr 
    370                 375                 380                 


Ala Gly Ala Ser Gly Gly Ala Tyr Gly Ser Gln Met Met Gly Gly Met 
385                 390                 395                 400 


Gly Leu Ser Asn Gln Ser Ser Tyr Gly Gly Pro Ala Ser Gln Gln Leu 
                405                 410                 415     


Ser Gly Gly Tyr Gly Gly Gly Tyr Gly Gly Gln Ser Ser Met Ser Gly 
            420                 425                 430         


Tyr Asp Gln Val Leu Gln Glu Asn Ser Ser Asp Phe Gln Ser Asn Ile 
        435                 440                 445             


Ala 
    


<210>  14
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Glu Gln Val Asn Glu Leu Lys Glu Lys Gly Asn Lys Ala Leu Ser 
1               5                   10                  15      


Val Gly Asn Ile Asp Asp Ala Leu Gln Cys Tyr Ser Glu Ala Ile Lys 
            20                  25                  30          


Leu Asp Pro His Asn His Val Leu Tyr Ser Asn Arg Ser Ala Ala Tyr 
        35                  40                  45              


Ala Lys Lys Gly Asp Tyr Gln Lys Ala Tyr Glu Asp Gly Cys Lys Thr 
    50                  55                  60                  


Val Asp Leu Lys Pro Asp Trp Gly Lys Gly Tyr Ser Arg Lys Ala Ala 
65                  70                  75                  80  


Ala Leu Glu Phe Leu Asn Arg Phe Glu Glu Ala Lys Arg Thr Tyr Glu 
                85                  90                  95      


Glu Gly Leu Lys His Glu Ala Asn Asn Pro Gln Leu Lys Glu Gly Leu 
            100                 105                 110         


Gln Asn Met Glu Ala Arg Leu Ala Glu Arg Lys Phe Met Asn Pro Phe 
        115                 120                 125             


Asn Met Pro Asn Leu Tyr Gln Lys Leu Glu Ser Asp Pro Arg Thr Arg 
    130                 135                 140                 


Thr Leu Leu Ser Asp Pro Thr Tyr Arg Glu Leu Ile Glu Gln Leu Arg 
145                 150                 155                 160 


Asn Lys Pro Ser Asp Leu Gly Thr Lys Leu Gln Asp Pro Arg Ile Met 
                165                 170                 175     


Thr Thr Leu Ser Val Leu Leu Gly Val Asp Leu Gly Ser Met Asp Glu 
            180                 185                 190         


Glu Glu Glu Ile Ala Thr Pro Pro Pro Pro Pro Pro Pro Lys Lys Glu 
        195                 200                 205             


Thr Lys Pro Glu Pro Met Glu Glu Asp Leu Pro Glu Asn Lys Lys Gln 
    210                 215                 220                 


Ala Leu Lys Glu Lys Glu Leu Gly Asn Asp Ala Tyr Lys Lys Lys Asp 
225                 230                 235                 240 


Phe Asp Thr Ala Leu Lys His Tyr Asp Lys Ala Lys Glu Leu Asp Pro 
                245                 250                 255     


Thr Asn Met Thr Tyr Ile Thr Asn Gln Ala Ala Val Tyr Phe Glu Lys 
            260                 265                 270         


Gly Asp Tyr Asn Lys Cys Arg Glu Leu Cys Glu Lys Ala Ile Glu Val 
        275                 280                 285             


Gly Arg Glu Asn Arg Glu Asp Tyr Arg Gln Ile Ala Lys Ala Tyr Ala 
    290                 295                 300                 


Arg Ile Gly Asn Ser Tyr Phe Lys Glu Glu Lys Tyr Lys Asp Ala Ile 
305                 310                 315                 320 


His Phe Tyr Asn Lys Ser Leu Ala Glu His Arg Thr Pro Asp Val Leu 
                325                 330                 335     


Lys Lys Cys Gln Gln Ala Glu Lys Ile Leu Lys Glu Gln Glu Arg Leu 
            340                 345                 350         


Ala Tyr Ile Asn Pro Asp Leu Ala Leu Glu Glu Lys Asn Lys Gly Asn 
        355                 360                 365             


Glu Cys Phe Gln Lys Gly Asp Tyr Pro Gln Ala Met Lys His Tyr Thr 
    370                 375                 380                 


Glu Ala Ile Lys Arg Asn Pro Lys Asp Ala Lys Leu Tyr Ser Asn Arg 
385                 390                 395                 400 


Ala Ala Cys Tyr Thr Lys Leu Leu Glu Phe Gln Leu Ala Leu Lys Asp 
                405                 410                 415     


Cys Glu Glu Cys Ile Gln Leu Glu Pro Thr Phe Ile Lys Gly Tyr Thr 
            420                 425                 430         


Arg Lys Ala Ala Ala Leu Glu Ala Met Lys Asp Tyr Thr Lys Ala Met 
        435                 440                 445             


Asp Val Tyr Gln Lys Ala Leu Asp Leu Asp Ser Ser Cys Lys Glu Ala 
    450                 455                 460                 


Ala Asp Gly Tyr Gln Arg Cys Met Met Ala Gln Tyr Asn Arg His Asp 
465                 470                 475                 480 


Ser Pro Glu Asp Val Lys Arg Arg Ala Met Ala Asp Pro Glu Val Gln 
                485                 490                 495     


Gln Ile Met Ser Asp Pro Ala Met Arg Leu Ile Leu Glu Gln Met Gln 
            500                 505                 510         


Lys Asp Pro Gln Ala Leu Ser Glu His Leu Lys Asn Pro Val Ile Ala 
        515                 520                 525             


Gln Lys Ile Gln Lys Leu Met Asp Val Gly Leu Ile Ala Ile Arg 
    530                 535                 540             


<210>  15
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ala Pro Ser Arg Lys Phe Phe Val Gly Gly Asn Trp Lys Met Asn 
1               5                   10                  15      


Gly Arg Lys Gln Ser Leu Gly Glu Leu Ile Gly Thr Leu Asn Ala Ala 
            20                  25                  30          


Lys Val Pro Ala Asp Thr Glu Val Val Cys Ala Pro Pro Thr Ala Tyr 
        35                  40                  45              


Ile Asp Phe Ala Arg Gln Lys Leu Asp Pro Lys Ile Ala Val Ala Ala 
    50                  55                  60                  


Gln Asn Cys Tyr Lys Val Thr Asn Gly Ala Phe Thr Gly Glu Ile Ser 
65                  70                  75                  80  


Pro Gly Met Ile Lys Asp Cys Gly Ala Thr Trp Val Val Leu Gly His 
                85                  90                  95      


Ser Glu Arg Arg His Val Phe Gly Glu Ser Asp Glu Leu Ile Gly Gln 
            100                 105                 110         


Lys Val Ala His Ala Leu Ala Glu Gly Leu Gly Val Ile Ala Cys Ile 
        115                 120                 125             


Gly Glu Lys Leu Asp Glu Arg Glu Ala Gly Ile Thr Glu Lys Val Val 
    130                 135                 140                 


Phe Glu Gln Thr Lys Val Ile Ala Asp Asn Val Lys Asp Trp Ser Lys 
145                 150                 155                 160 


Val Val Leu Ala Tyr Glu Pro Val Trp Ala Ile Gly Thr Gly Lys Thr 
                165                 170                 175     


Ala Thr Pro Gln Gln Ala Gln Glu Val His Glu Lys Leu Arg Gly Trp 
            180                 185                 190         


Leu Lys Ser Asn Val Ser Asp Ala Val Ala Gln Ser Thr Arg Ile Ile 
        195                 200                 205             


Tyr Gly Gly Ser Val Thr Gly Ala Thr Cys Lys Glu Leu Ala Ser Gln 
    210                 215                 220                 


Pro Asp Val Asp Gly Phe Leu Val Gly Gly Ala Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Phe Val Asp Ile Ile Asn Ala Lys Gln 
                245                 


<210>  16
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Pro Gly Gly Leu Leu Leu Gly Asp Val Ala Pro Asn Phe Glu Ala 
1               5                   10                  15      


Asn Thr Thr Val Gly Arg Ile Arg Phe His Asp Phe Leu Gly Asp Ser 
            20                  25                  30          


Trp Gly Ile Leu Phe Ser His Pro Arg Asp Phe Thr Pro Val Cys Thr 
        35                  40                  45              


Thr Glu Leu Gly Arg Ala Ala Lys Leu Ala Pro Glu Phe Ala Lys Arg 
    50                  55                  60                  


Asn Val Lys Leu Ile Ala Leu Ser Ile Asp Ser Val Glu Asp His Leu 
65                  70                  75                  80  


Ala Trp Ser Lys Asp Ile Asn Ala Tyr Asn Cys Glu Glu Pro Thr Glu 
                85                  90                  95      


Lys Leu Pro Phe Pro Ile Ile Asp Asp Arg Asn Arg Glu Leu Ala Ile 
            100                 105                 110         


Leu Leu Gly Met Leu Asp Pro Ala Glu Lys Asp Glu Lys Gly Met Pro 
        115                 120                 125             


Val Thr Ala Arg Val Val Phe Val Phe Gly Pro Asp Lys Lys Leu Lys 
    130                 135                 140                 


Leu Ser Ile Leu Tyr Pro Ala Thr Thr Gly Arg Asn Phe Asp Glu Ile 
145                 150                 155                 160 


Leu Arg Val Val Ile Ser Leu Gln Leu Thr Ala Glu Lys Arg Val Ala 
                165                 170                 175     


Thr Pro Val Asp Trp Lys Asp Gly Asp Ser Val Met Val Leu Pro Thr 
            180                 185                 190         


Ile Pro Glu Glu Glu Ala Lys Lys Leu Phe Pro Lys Gly Val Phe Thr 
        195                 200                 205             


Lys Glu Leu Pro Ser Gly Lys Lys Tyr Leu Arg Tyr Thr Pro Gln Pro 
    210                 215                 220                 


<210>  17
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ala Arg Gly Gly Arg Gly Arg Arg Leu Gly Leu Ala Leu Gly Leu 
1               5                   10                  15      


Leu Leu Ala Leu Val Leu Ala Pro Arg Val Leu Arg Ala Lys Pro Thr 
            20                  25                  30          


Val Arg Lys Glu Arg Val Val Arg Pro Asp Ser Glu Leu Gly Glu Arg 
        35                  40                  45              


Pro Pro Glu Asp Asn Gln Ser Phe Gln Tyr Asp His Glu Ala Phe Leu 
    50                  55                  60                  


Gly Lys Glu Asp Ser Lys Thr Phe Asp Gln Leu Thr Pro Asp Glu Ser 
65                  70                  75                  80  


Lys Glu Arg Leu Gly Lys Ile Val Asp Arg Ile Asp Asn Asp Gly Asp 
                85                  90                  95      


Gly Phe Val Thr Thr Glu Glu Leu Lys Thr Trp Ile Lys Arg Val Gln 
            100                 105                 110         


Lys Arg Tyr Ile Phe Asp Asn Val Ala Lys Val Trp Lys Asp Tyr Asp 
        115                 120                 125             


Arg Asp Lys Asp Asp Lys Ile Ser Trp Glu Glu Tyr Lys Gln Ala Thr 
    130                 135                 140                 


Tyr Gly Tyr Tyr Leu Gly Asn Pro Ala Glu Phe His Asp Ser Ser Asp 
145                 150                 155                 160 


His His Thr Phe Lys Lys Met Leu Pro Arg Asp Glu Arg Arg Phe Lys 
                165                 170                 175     


Ala Ala Asp Leu Asn Gly Asp Leu Thr Ala Thr Arg Glu Glu Phe Thr 
            180                 185                 190         


Ala Phe Leu His Pro Glu Glu Phe Glu His Met Lys Glu Ile Val Val 
        195                 200                 205             


Leu Glu Thr Leu Glu Asp Ile Asp Lys Asn Gly Asp Gly Phe Val Asp 
    210                 215                 220                 


Gln Asp Glu Tyr Ile Ala Asp Met Phe Ser His Glu Glu Asn Gly Pro 
225                 230                 235                 240 


Glu Pro Asp Trp Val Leu Ser Glu Arg Glu Gln Phe Asn Glu Phe Arg 
                245                 250                 255     


Asp Leu Asn Lys Asp Gly Lys Leu Asp Lys Asp Glu Ile Arg His Trp 
            260                 265                 270         


Ile Leu Pro Gln Asp Tyr Asp His Ala Gln Ala Glu Ala Arg His Leu 
        275                 280                 285             


Val Tyr Glu Ser Asp Lys Asn Lys Asp Glu Lys Leu Thr Lys Glu Glu 
    290                 295                 300                 


Ile Leu Glu Asn Trp Asn Met Phe Val Gly Ser Gln Ala Thr Asn Tyr 
305                 310                 315                 320 


Gly Glu Asp Leu Thr Lys Asn His Asp Glu Leu 
                325                 330     


<210>  18
<211>  654
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Arg Ala Glu Glu Glu Asp Lys Lys Glu Asp Val Gly Thr Val Val Gly 
            20                  25                  30          


Ile Asp Leu Gly Thr Thr Tyr Ser Cys Val Gly Val Phe Lys Asn Gly 
        35                  40                  45              


Arg Val Glu Ile Ile Ala Asn Asp Gln Gly Asn Arg Ile Thr Pro Ser 
    50                  55                  60                  


Tyr Val Ala Phe Thr Pro Glu Gly Glu Arg Leu Ile Gly Asp Ala Ala 
65                  70                  75                  80  


Lys Asn Gln Leu Thr Ser Asn Pro Glu Asn Thr Val Phe Asp Ala Lys 
                85                  90                  95      


Arg Leu Ile Gly Arg Thr Trp Asn Asp Pro Ser Val Gln Gln Asp Ile 
            100                 105                 110         


Lys Phe Leu Pro Phe Lys Val Val Glu Lys Lys Thr Lys Pro Tyr Ile 
        115                 120                 125             


Gln Val Asp Ile Gly Gly Gly Gln Thr Lys Thr Phe Ala Pro Glu Glu 
    130                 135                 140                 


Ile Ser Ala Met Val Leu Thr Lys Met Lys Glu Thr Ala Glu Ala Tyr 
145                 150                 155                 160 


Leu Gly Lys Lys Val Thr His Ala Val Val Thr Val Pro Ala Tyr Phe 
                165                 170                 175     


Asn Asp Ala Gln Arg Gln Ala Thr Lys Asp Ala Gly Thr Ile Ala Gly 
            180                 185                 190         


Leu Asn Val Met Arg Ile Ile Asn Glu Pro Thr Ala Ala Ala Ile Ala 
        195                 200                 205             


Tyr Gly Leu Asp Lys Arg Glu Gly Glu Lys Asn Ile Leu Val Phe Asp 
    210                 215                 220                 


Leu Gly Gly Gly Thr Phe Asp Val Ser Leu Leu Thr Ile Asp Asn Gly 
225                 230                 235                 240 


Val Phe Glu Val Val Ala Thr Asn Gly Asp Thr His Leu Gly Gly Glu 
                245                 250                 255     


Asp Phe Asp Gln Arg Val Met Glu His Phe Ile Lys Leu Tyr Lys Lys 
            260                 265                 270         


Lys Thr Gly Lys Asp Val Arg Lys Asp Asn Arg Ala Val Gln Lys Leu 
        275                 280                 285             


Arg Arg Glu Val Glu Lys Ala Lys Arg Ala Leu Ser Ser Gln His Gln 
    290                 295                 300                 


Ala Arg Ile Glu Ile Glu Ser Phe Tyr Glu Gly Glu Asp Phe Ser Glu 
305                 310                 315                 320 


Thr Leu Thr Arg Ala Lys Phe Glu Glu Leu Asn Met Asp Leu Phe Arg 
                325                 330                 335     


Ser Thr Met Lys Pro Val Gln Lys Val Leu Glu Asp Ser Asp Leu Lys 
            340                 345                 350         


Lys Ser Asp Ile Asp Glu Ile Val Leu Val Gly Gly Ser Thr Arg Ile 
        355                 360                 365             


Pro Lys Ile Gln Gln Leu Val Lys Glu Phe Phe Asn Gly Lys Glu Pro 
    370                 375                 380                 


Ser Arg Gly Ile Asn Pro Asp Glu Ala Val Ala Tyr Gly Ala Ala Val 
385                 390                 395                 400 


Gln Ala Gly Val Leu Ser Gly Asp Gln Asp Thr Gly Asp Leu Val Leu 
                405                 410                 415     


Leu Asp Val Cys Pro Leu Thr Leu Gly Ile Glu Thr Val Gly Gly Val 
            420                 425                 430         


Met Thr Lys Leu Ile Pro Arg Asn Thr Val Val Pro Thr Lys Lys Ser 
        435                 440                 445             


Gln Ile Phe Ser Thr Ala Ser Asp Asn Gln Pro Thr Val Thr Ile Lys 
    450                 455                 460                 


Val Tyr Glu Gly Glu Arg Pro Leu Thr Lys Asp Asn His Leu Leu Gly 
465                 470                 475                 480 


Thr Phe Asp Leu Thr Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln 
                485                 490                 495     


Ile Glu Val Thr Phe Glu Ile Asp Val Asn Gly Ile Leu Arg Val Thr 
            500                 505                 510         


Ala Glu Asp Lys Gly Thr Gly Asn Lys Asn Lys Ile Thr Ile Thr Asn 
        515                 520                 525             


Asp Gln Asn Arg Leu Thr Pro Glu Glu Ile Glu Arg Met Val Asn Asp 
    530                 535                 540                 


Ala Glu Lys Phe Ala Glu Glu Asp Lys Lys Leu Lys Glu Arg Ile Asp 
545                 550                 555                 560 


Thr Arg Asn Glu Leu Glu Ser Tyr Ala Tyr Ser Leu Lys Asn Gln Ile 
                565                 570                 575     


Gly Asp Lys Glu Lys Leu Gly Gly Lys Leu Ser Ser Glu Asp Lys Glu 
            580                 585                 590         


Thr Met Glu Lys Ala Val Glu Glu Lys Ile Glu Trp Leu Glu Ser His 
        595                 600                 605             


Gln Asp Ala Asp Ile Glu Asp Phe Lys Ala Lys Lys Lys Glu Leu Glu 
    610                 615                 620                 


Glu Ile Val Gln Pro Ile Ile Ser Lys Leu Tyr Gly Ser Ala Gly Pro 
625                 630                 635                 640 


Pro Pro Thr Gly Glu Glu Asp Thr Ala Glu Lys Asp Glu Leu 
                645                 650                 


<210>  19
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ser Thr Arg Ser Val Ser Ser Ser Ser Tyr Arg Arg Met Phe Gly 
1               5                   10                  15      


Gly Pro Gly Thr Ala Ser Arg Pro Ser Ser Ser Arg Ser Tyr Val Thr 
            20                  25                  30          


Thr Ser Thr Arg Thr Tyr Ser Leu Gly Ser Ala Leu Arg Pro Ser Thr 
        35                  40                  45              


Ser Arg Ser Leu Tyr Ala Ser Ser Pro Gly Gly Val Tyr Ala Thr Arg 
    50                  55                  60                  


Ser Ser Ala Val Arg Leu Arg Ser Ser Val Pro Gly Val Arg Leu Leu 
65                  70                  75                  80  


Gln Asp Ser Val Asp Phe Ser Leu Ala Asp Ala Ile Asn Thr Glu Phe 
                85                  90                  95      


Lys Asn Thr Arg Thr Asn Glu Lys Val Glu Leu Gln Glu Leu Asn Asp 
            100                 105                 110         


Arg Phe Ala Asn Tyr Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn 
        115                 120                 125             


Lys Ile Leu Leu Ala Glu Leu Glu Gln Leu Lys Gly Gln Gly Lys Ser 
    130                 135                 140                 


Arg Leu Gly Asp Leu Tyr Glu Glu Glu Met Arg Glu Leu Arg Arg Gln 
145                 150                 155                 160 


Val Asp Gln Leu Thr Asn Asp Lys Ala Arg Val Glu Val Glu Arg Asp 
                165                 170                 175     


Asn Leu Ala Glu Asp Ile Met Arg Leu Arg Glu Lys Leu Gln Glu Glu 
            180                 185                 190         


Met Leu Gln Arg Glu Glu Ala Glu Asn Thr Leu Gln Ser Phe Arg Gln 
        195                 200                 205             


Asp Val Asp Asn Ala Ser Leu Ala Arg Leu Asp Leu Glu Arg Lys Val 
    210                 215                 220                 


Glu Ser Leu Gln Glu Glu Ile Ala Phe Leu Lys Lys Leu His Glu Glu 
225                 230                 235                 240 


Glu Ile Gln Glu Leu Gln Ala Gln Ile Gln Glu Gln His Val Gln Ile 
                245                 250                 255     


Asp Val Asp Val Ser Lys Pro Asp Leu Thr Ala Ala Leu Arg Asp Val 
            260                 265                 270         


Arg Gln Gln Tyr Glu Ser Val Ala Ala Lys Asn Leu Gln Glu Ala Glu 
        275                 280                 285             


Glu Trp Tyr Lys Ser Lys Phe Ala Asp Leu Ser Glu Ala Ala Asn Arg 
    290                 295                 300                 


Asn Asn Asp Ala Leu Arg Gln Ala Lys Gln Glu Ser Thr Glu Tyr Arg 
305                 310                 315                 320 


Arg Gln Val Gln Ser Leu Thr Cys Glu Val Asp Ala Leu Lys Gly Thr 
                325                 330                 335     


Asn Glu Ser Leu Glu Arg Gln Met Arg Glu Met Glu Glu Asn Phe Ala 
            340                 345                 350         


Val Glu Ala Ala Asn Tyr Gln Asp Thr Ile Gly Arg Leu Gln Asp Glu 
        355                 360                 365             


Ile Gln Asn Met Lys Glu Glu Met Ala Arg His Leu Arg Glu Tyr Gln 
    370                 375                 380                 


Asp Leu Leu Asn Val Lys Met Ala Leu Asp Ile Glu Ile Ala Thr Tyr 
385                 390                 395                 400 


Arg Lys Leu Leu Glu Gly Glu Glu Ser Arg Ile Ser Leu Pro Leu Pro 
                405                 410                 415     


Asn Phe Ser Ser Leu Asn Leu Arg Glu Thr Asn Leu Asp Ser Leu Pro 
            420                 425                 430         


Leu Val Asp Thr His Ser Lys Arg Thr Leu Leu Ile Lys Thr Val Glu 
        435                 440                 445             


Thr Arg Asp Gly Gln Val Ile Asn Glu Thr Ser Gln His His Asp Asp 
    450                 455                 460                 


Leu Glu 
465     


<210>  20
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys 
    50                  55                  60                  


Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys 
65                  70                  75                  80  


Lys Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu 
                85                  90                  95      


Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala 
                165                 170                 175     


Asn Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu 
            180                 185                 190         


Lys Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu 
    210                 215                 220                 


Glu Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser 
            260                 265                 270         


Pro Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp 
    290                 295                 300                 


Gln Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ser Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu 
                405                 410                 415     


Leu Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu 
            420                 425                 430         


Ala Lys 
        


<210>  21
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Ser Gly Asn Ala Arg Ile Gly Lys Pro Ala Pro Asp Phe Lys 
1               5                   10                  15      


Ala Thr Ala Val Val Asp Gly Ala Phe Lys Glu Val Lys Leu Ser Asp 
            20                  25                  30          


Tyr Lys Gly Lys Tyr Val Val Leu Phe Phe Tyr Pro Leu Asp Phe Thr 
        35                  40                  45              


Phe Val Cys Pro Thr Glu Ile Ile Ala Phe Ser Asn Arg Ala Glu Asp 
    50                  55                  60                  


Phe Arg Lys Leu Gly Cys Glu Val Leu Gly Val Ser Val Asp Ser Gln 
65                  70                  75                  80  


Phe Thr His Leu Ala Trp Ile Asn Thr Pro Arg Lys Glu Gly Gly Leu 
                85                  90                  95      


Gly Pro Leu Asn Ile Pro Leu Leu Ala Asp Val Thr Arg Arg Leu Ser 
            100                 105                 110         


Glu Asp Tyr Gly Val Leu Lys Thr Asp Glu Gly Ile Ala Tyr Arg Gly 
        115                 120                 125             


Leu Phe Ile Ile Asp Gly Lys Gly Val Leu Arg Gln Ile Thr Val Asn 
    130                 135                 140                 


Asp Leu Pro Val Gly Arg Ser Val Asp Glu Ala Leu Arg Leu Val Gln 
145                 150                 155                 160 


Ala Phe Gln Tyr Thr Asp Glu His Gly Glu Val Cys Pro Ala Gly Trp 
                165                 170                 175     


Lys Pro Gly Ser Asp Thr Ile Lys Pro Asn Val Asp Asp Ser Lys Glu 
            180                 185                 190         


Tyr Phe Ser Lys His Asn 
        195             


<210>  22
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Ala Ala Val Gly Arg Leu Leu Arg Ala Ser Val Ala Arg His 
1               5                   10                  15      


Val Ser Ala Ile Pro Trp Gly Ile Ser Ala Thr Ala Ala Leu Arg Pro 
            20                  25                  30          


Ala Ala Cys Gly Arg Thr Ser Leu Thr Asn Leu Leu Cys Ser Gly Ser 
        35                  40                  45              


Ser Gln Ala Lys Leu Phe Ser Thr Ser Ser Ser Cys His Ala Pro Ala 
    50                  55                  60                  


Val Thr Gln His Ala Pro Tyr Phe Lys Gly Thr Ala Val Val Asn Gly 
65                  70                  75                  80  


Glu Phe Lys Asp Leu Ser Leu Asp Asp Phe Lys Gly Lys Tyr Leu Val 
                85                  90                  95      


Leu Phe Phe Tyr Pro Leu Asp Phe Thr Phe Val Cys Pro Thr Glu Ile 
            100                 105                 110         


Val Ala Phe Ser Asp Lys Ala Asn Glu Phe His Asp Val Asn Cys Glu 
        115                 120                 125             


Val Val Ala Val Ser Val Asp Ser His Phe Ser His Leu Ala Trp Ile 
    130                 135                 140                 


Asn Thr Pro Arg Lys Asn Gly Gly Leu Gly His Met Asn Ile Ala Leu 
145                 150                 155                 160 


Leu Ser Asp Leu Thr Lys Gln Ile Ser Arg Asp Tyr Gly Val Leu Leu 
                165                 170                 175     


Glu Gly Ser Gly Leu Ala Leu Arg Gly Leu Phe Ile Ile Asp Pro Asn 
            180                 185                 190         


Gly Val Ile Lys His Leu Ser Val Asn Asp Leu Pro Val Gly Arg Ser 
        195                 200                 205             


Val Glu Glu Thr Leu Arg Leu Val Lys Ala Phe Gln Tyr Val Glu Thr 
    210                 215                 220                 


His Gly Glu Val Cys Pro Ala Asn Trp Thr Pro Asp Ser Pro Thr Ile 
225                 230                 235                 240 


Lys Pro Ser Pro Ala Ala Ser Lys Glu Tyr Phe Gln Lys Val Asn Gln 
                245                 250                 255     


<210>  23
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ala Ala Ala Lys Asp Thr His Glu Asp His Asp Thr Ser Thr Glu 
1               5                   10                  15      


Asn Thr Asp Glu Ser Asn His Asp Pro Gln Phe Glu Pro Ile Val Ser 
            20                  25                  30          


Leu Pro Glu Gln Glu Ile Lys Thr Leu Glu Glu Asp Glu Glu Glu Leu 
        35                  40                  45              


Phe Lys Met Arg Ala Lys Leu Phe Arg Phe Ala Ser Glu Asn Asp Leu 
    50                  55                  60                  


Pro Glu Trp Lys Glu Arg Gly Thr Gly Asp Val Lys Leu Leu Lys His 
65                  70                  75                  80  


Lys Glu Lys Gly Ala Ile Arg Leu Leu Met Arg Arg Asp Lys Thr Leu 
                85                  90                  95      


Lys Ile Cys Ala Asn His Tyr Ile Thr Pro Met Met Glu Leu Lys Pro 
            100                 105                 110         


Asn Ala Gly Ser Asp Arg Ala Trp Val Trp Asn Thr His Ala Asp Phe 
        115                 120                 125             


Ala Asp Glu Cys Pro Lys Pro Glu Leu Leu Ala Ile Arg Phe Leu Asn 
    130                 135                 140                 


Ala Glu Asn Ala Gln Lys Phe Lys Thr Lys Phe Glu Glu Cys Arg Lys 
145                 150                 155                 160 


Glu Ile Glu Glu Arg Glu Lys Lys Ala Gly Ser Gly Lys Asn Asp His 
                165                 170                 175     


Ala Glu Lys Val Ala Glu Lys Leu Glu Ala Leu Ser Val Lys Glu Glu 
            180                 185                 190         


Thr Lys Glu Asp Ala Glu Glu Lys Gln 
        195                 200     


<210>  24
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr 
1               5                   10                  15      


Ala Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro 
            20                  25                  30          


Asp Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg 
        35                  40                  45              


Trp Lys Thr Met Ser Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala 
    50                  55                  60                  


Lys Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro 
65                  70                  75                  80  


Pro Lys Gly Glu Thr Lys Lys Lys Phe Lys Asp Pro Asn Ala Pro Lys 
                85                  90                  95      


Arg Pro Pro Ser Ala Phe Phe Leu Phe Cys Ser Glu Tyr Arg Pro Lys 
            100                 105                 110         


Ile Lys Gly Glu His Pro Gly Leu Ser Ile Gly Asp Val Ala Lys Lys 
        115                 120                 125             


Leu Gly Glu Met Trp Asn Asn Thr Ala Ala Asp Asp Lys Gln Pro Tyr 
    130                 135                 140                 


Glu Lys Lys Ala Ala Lys Leu Lys Glu Lys Tyr Glu Lys Asp Ile Ala 
145                 150                 155                 160 


Ala Tyr Arg Ala Lys Gly Lys Pro Asp Ala Ala Lys Lys Gly Val Val 
                165                 170                 175     


Lys Ala Glu Lys Ser Lys Lys Lys Lys Glu Glu Glu Glu Asp Glu Glu 
            180                 185                 190         


Asp Glu Glu Asp Glu Glu Glu Glu Glu Asp Glu Glu Asp Glu Asp Glu 
        195                 200                 205             


Glu Glu Asp Asp Asp Asp Glu 
    210                 215 


