                         SEQUENCE LISTING

<110>  The Provost, Fellows and Scholars of the College of the 
       Holy and Undivided Trinity of Queen Elizabeth, near Dublin
       O'NEILL, Luke
       CARPENTER, Susan
 
<120>  Compounds and Methods for the Treatment of Inflammatory Disease

<130>  P107318.WO.01

<150>  EP08164464.3
<151>  2008-09-16

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  811
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Ala Ala Arg Ala Leu Arg Leu Leu Leu Val Val Cys Gly Cys 
1               5                   10                  15      


Leu Ala Leu Pro Pro Leu Ala Glu Pro Val Cys Pro Glu Arg Cys Asp 
            20                  25                  30          


Cys Gln His Pro Gln His Leu Leu Cys Thr Asn Arg Gly Leu Arg Val 
        35                  40                  45              


Val Pro Lys Thr Ser Ser Leu Pro Ser Pro His Asp Val Leu Thr Tyr 
    50                  55                  60                  


Ser Leu Gly Gly Asn Phe Ile Thr Asn Ile Thr Ala Phe Asp Phe His 
65                  70                  75                  80  


Arg Leu Gly Gln Leu Arg Arg Leu Asp Leu Gln Tyr Asn Gln Ile Arg 
                85                  90                  95      


Ser Leu His Pro Lys Thr Phe Glu Lys Leu Ser Arg Leu Glu Glu Leu 
            100                 105                 110         


Tyr Leu Gly Asn Asn Leu Leu Gln Ala Leu Ala Pro Gly Thr Leu Ala 
        115                 120                 125             


Pro Leu Arg Lys Leu Arg Ile Leu Tyr Ala Asn Gly Asn Glu Ile Ser 
    130                 135                 140                 


Arg Leu Ser Arg Gly Ser Phe Glu Gly Leu Glu Ser Leu Val Lys Leu 
145                 150                 155                 160 


Arg Leu Asp Gly Asn Ala Leu Gly Ala Leu Pro Asp Ala Val Phe Ala 
                165                 170                 175     


Pro Leu Gly Asn Leu Leu Tyr Leu His Leu Glu Ser Asn Arg Ile Arg 
            180                 185                 190         


Phe Leu Gly Lys Asn Ala Phe Ala Gln Leu Gly Lys Leu Arg Phe Leu 
        195                 200                 205             


Asn Leu Ser Ala Asn Glu Leu Gln Pro Ser Leu Arg His Ala Ala Thr 
    210                 215                 220                 


Phe Ala Pro Leu Arg Ser Leu Ser Ser Leu Ile Leu Ser Ala Asn Ser 
225                 230                 235                 240 


Leu Gln His Leu Gly Pro Arg Ile Phe Gln His Leu Pro Arg Leu Gly 
                245                 250                 255     


Leu Leu Ser Leu Arg Gly Asn Gln Leu Thr His Leu Ala Pro Glu Ala 
            260                 265                 270         


Phe Trp Gly Leu Glu Ala Leu Arg Glu Leu Arg Leu Glu Gly Asn Arg 
        275                 280                 285             


Leu Ser Gln Leu Pro Thr Ala Leu Leu Glu Pro Leu His Ser Leu Glu 
    290                 295                 300                 


Ala Leu Asp Leu Ser Gly Asn Glu Leu Ser Ala Leu His Pro Ala Thr 
305                 310                 315                 320 


Phe Gly His Leu Gly Arg Leu Arg Glu Leu Ser Leu Arg Asn Asn Ala 
                325                 330                 335     


Leu Ser Ala Leu Ser Gly Asp Ile Phe Ala Ala Ser Pro Ala Leu Tyr 
            340                 345                 350         


Arg Leu Asp Leu Asp Gly Asn Gly Trp Thr Cys Asp Cys Arg Leu Arg 
        355                 360                 365             


Gly Leu Lys Arg Trp Met Gly Asp Trp His Ser Gln Gly Arg Leu Leu 
    370                 375                 380                 


Thr Val Phe Val Gln Cys Arg His Pro Pro Ala Leu Arg Gly Lys Tyr 
385                 390                 395                 400 


Leu Asp Tyr Leu Asp Asp Gln Gln Leu Gln Asn Gly Ser Cys Ala Asp 
                405                 410                 415     


Pro Ser Pro Ser Ala Ser Leu Thr Ala Asp Arg Arg Arg Gln Pro Leu 
            420                 425                 430         


Pro Thr Ala Ala Gly Glu Glu Met Thr Pro Pro Ala Gly Leu Ala Glu 
        435                 440                 445             


Glu Leu Pro Pro Gln Pro Gln Leu Gln Gln Gln Gly Arg Phe Leu Ala 
    450                 455                 460                 


Gly Val Ala Trp Asp Gly Ala Ala Arg Glu Leu Val Gly Asn Arg Ser 
465                 470                 475                 480 


Ala Leu Arg Leu Ser Arg Arg Gly Pro Gly Leu Gln Gln Pro Ser Pro 
                485                 490                 495     


Ser Val Ala Ala Ala Ala Gly Pro Ala Pro Gln Ser Leu Asp Leu His 
            500                 505                 510         


Lys Lys Pro Gln Arg Gly Arg Pro Thr Arg Ala Asp Pro Ala Leu Ala 
        515                 520                 525             


Glu Pro Thr Pro Thr Ala Ser Pro Gly Ser Ala Pro Ser Pro Ala Gly 
    530                 535                 540                 


Asp Pro Trp Gln Arg Ala Thr Lys His Arg Leu Gly Thr Glu His Gln 
545                 550                 555                 560 


Glu Arg Ala Ala Gln Ser Asp Gly Gly Ala Gly Leu Pro Pro Leu Val 
                565                 570                 575     


Ser Asp Pro Cys Asp Phe Asn Lys Phe Ile Leu Cys Asn Leu Thr Val 
            580                 585                 590         


Glu Ala Val Gly Ala Asp Ser Ala Ser Val Arg Trp Ala Val Arg Glu 
        595                 600                 605             


His Arg Ser Pro Arg Pro Leu Gly Gly Ala Arg Phe Arg Leu Leu Phe 
    610                 615                 620                 


Asp Arg Phe Gly Gln Gln Pro Lys Phe His Arg Phe Val Tyr Leu Pro 
625                 630                 635                 640 


Glu Ser Ser Asp Ser Ala Thr Leu Arg Glu Leu Arg Gly Asp Thr Pro 
                645                 650                 655     


Tyr Leu Val Cys Val Glu Gly Val Leu Gly Gly Arg Val Cys Pro Val 
            660                 665                 670         


Ala Pro Arg Asp His Cys Ala Gly Leu Val Thr Leu Pro Glu Ala Gly 
        675                 680                 685             


Ser Arg Gly Gly Val Asp Tyr Gln Leu Leu Thr Leu Ala Leu Leu Thr 
    690                 695                 700                 


Val Asn Ala Leu Leu Val Leu Leu Ala Leu Ala Ala Trp Ala Ser Arg 
705                 710                 715                 720 


Trp Leu Arg Arg Lys Leu Arg Ala Arg Arg Lys Gly Gly Ala Pro Val 
                725                 730                 735     


His Val Arg His Met Tyr Ser Thr Arg Arg Pro Leu Arg Ser Met Gly 
            740                 745                 750         


Thr Gly Val Ser Ala Asp Phe Ser Gly Phe Gln Ser His Arg Pro Arg 
        755                 760                 765             


Thr Thr Val Cys Ala Leu Ser Glu Ala Asp Leu Ile Glu Phe Pro Cys 
    770                 775                 780                 


Asp Arg Phe Met Asp Ser Ala Gly Gly Gly Ala Gly Gly Ser Leu Arg 
785                 790                 795                 800 


Arg Glu Asp Arg Leu Leu Gln Arg Phe Ala Asp 
                805                 810     


<210>  2
<211>  809
<212>  PRT
<213>  Mus musculus

<400>  2

Met Glu Gly Val Gly Ala Val Arg Phe Trp Leu Val Val Cys Gly Cys 
1               5                   10                  15      


Leu Ala Phe Pro Pro Arg Ala Glu Ser Val Cys Pro Glu Arg Cys Asp 
            20                  25                  30          


Cys Gln His Pro Gln His Leu Leu Cys Thr Asn Arg Gly Leu Arg Ala 
        35                  40                  45              


Val Pro Lys Thr Ser Ser Leu Pro Ser Pro Gln Asp Val Leu Thr Tyr 
    50                  55                  60                  


Ser Leu Gly Gly Asn Phe Ile Thr Asn Ile Thr Ala Phe Asp Phe His 
65                  70                  75                  80  


Arg Leu Gly Gln Leu Arg Arg Leu Asp Leu Gln Tyr Asn Gln Ile Arg 
                85                  90                  95      


Ser Leu His Pro Lys Thr Phe Glu Lys Leu Ser Arg Leu Glu Glu Leu 
            100                 105                 110         


Tyr Leu Gly Asn Asn Leu Leu Gln Ala Leu Val Pro Gly Thr Leu Ala 
        115                 120                 125             


Pro Leu Arg Lys Leu Arg Ile Leu Tyr Ala Asn Gly Asn Glu Ile Gly 
    130                 135                 140                 


Arg Leu Ser Arg Gly Ser Phe Glu Gly Leu Glu Ser Leu Val Lys Leu 
145                 150                 155                 160 


Arg Leu Asp Gly Asn Val Leu Gly Ala Leu Pro Asp Ala Val Phe Ala 
                165                 170                 175     


Pro Leu Gly Asn Leu Leu Tyr Leu His Leu Glu Ser Asn Arg Ile Arg 
            180                 185                 190         


Phe Leu Gly Lys Asn Ala Phe Ser Gln Leu Gly Lys Leu Arg Phe Leu 
        195                 200                 205             


Asn Leu Ser Ala Asn Glu Leu Gln Pro Ser Leu Arg His Ala Ala Thr 
    210                 215                 220                 


Phe Val Pro Leu Arg Ser Leu Ser Thr Leu Ile Leu Ser Ala Asn Ser 
225                 230                 235                 240 


Leu Gln His Leu Gly Pro Arg Val Phe Gln His Leu Pro Arg Leu Gly 
                245                 250                 255     


Leu Leu Ser Leu Ser Gly Asn Gln Leu Thr His Leu Ala Pro Glu Ala 
            260                 265                 270         


Phe Trp Gly Leu Glu Ala Leu Arg Glu Leu Arg Leu Glu Gly Asn Arg 
        275                 280                 285             


Leu Asn Gln Leu Pro Leu Thr Leu Leu Glu Pro Leu His Ser Leu Glu 
    290                 295                 300                 


Ala Leu Asp Leu Ser Gly Asn Glu Leu Ser Ala Leu His Pro Ala Thr 
305                 310                 315                 320 


Phe Gly His Gln Gly Arg Leu Arg Glu Leu Ser Leu Arg Asp Asn Ala 
                325                 330                 335     


Leu Ser Ala Leu Ser Gly Asp Ile Phe Ala Ala Ser Pro Ala Leu Tyr 
            340                 345                 350         


Arg Leu Asp Leu Asp Gly Asn Gly Trp Thr Cys Asp Cys Arg Leu Arg 
        355                 360                 365             


Gly Leu Lys Arg Trp Met Gly Asn Trp His Ser Gln Gly Arg Leu Leu 
    370                 375                 380                 


Thr Val Phe Val Gln Cys Arg His Pro Pro Ala Leu Arg Gly Lys Tyr 
385                 390                 395                 400 


Leu Asp Tyr Leu Asp Asp Gln Leu Leu Gln Asn Gly Ser Cys Val Asp 
                405                 410                 415     


Pro Ser Pro Ser Pro Thr Ala Gly Ser Arg Gln Trp Pro Leu Pro Thr 
            420                 425                 430         


Ser Ser Glu Glu Gly Met Thr Pro Pro Ala Gly Leu Ser Gln Glu Leu 
        435                 440                 445             


Pro Leu Gln Pro Gln Pro Gln Pro Gln Gln Arg Gly Arg Leu Leu Pro 
    450                 455                 460                 


Gly Val Ala Trp Gly Gly Ala Ala Lys Glu Leu Val Gly Asn Arg Ser 
465                 470                 475                 480 


Ala Leu Arg Leu Ser Arg Arg Gly Pro Gly Pro His Gln Gly Pro Ser 
                485                 490                 495     


Ala Ala Ala Pro Gly Ser Ala Pro Gln Ser Leu Asp Leu His Glu Lys 
            500                 505                 510         


Pro Gly Arg Gly Arg His Thr Arg Ala Asn Leu Ser Gln Thr Glu Pro 
        515                 520                 525             


Thr Pro Thr Ser Glu Pro Ala Ser Gly Thr Pro Ser Ala Arg Asp Ser 
    530                 535                 540                 


Trp Gln Arg Ala Ala Lys Gln Arg Leu Ala Ser Glu Gln Gln Glu Ser 
545                 550                 555                 560 


Ala Val Gln Ser Val Ser Gly Val Gly Leu Pro Pro Leu Val Ser Asp 
                565                 570                 575     


Pro Cys Asp Phe Asn Lys Phe Ile Leu Cys Asn Leu Thr Val Glu Ala 
            580                 585                 590         


Val Ser Ala Asn Ser Ala Ser Val Arg Trp Ala Val Arg Glu His Arg 
        595                 600                 605             


Ser Pro Arg Pro Gln Gly Gly Ala Arg Phe Arg Leu Leu Phe Asp Arg 
    610                 615                 620                 


Phe Gly Gln Gln Pro Lys Phe Gln Arg Phe Val Tyr Leu Pro Glu Arg 
625                 630                 635                 640 


Ser Asp Ser Ala Thr Leu His Glu Leu Arg Gly Asp Thr Pro Tyr Leu 
                645                 650                 655     


Val Cys Val Glu Gly Val Leu Gly Gly Arg Val Cys Pro Val Ala Pro 
            660                 665                 670         


Arg Asp His Cys Ala Gly Leu Val Thr Leu Pro Glu Ala Gly Gly Arg 
        675                 680                 685             


Gly Gly Val Asp Tyr Gln Leu Leu Thr Leu Val Leu Leu Ala Val Asn 
    690                 695                 700                 


Ala Leu Leu Val Leu Leu Ala Leu Ala Ala Trp Gly Ser Arg Trp Leu 
705                 710                 715                 720 


Arg Arg Lys Leu Arg Ala Arg Arg Lys Gly Gly Ala Pro Val His Val 
                725                 730                 735     


Arg His Met Tyr Ser Thr Arg Arg Pro Leu Arg Ser Met Gly Thr Gly 
            740                 745                 750         


Val Ser Ala Asp Phe Ser Gly Phe Gln Ser His Arg Pro Arg Thr Thr 
        755                 760                 765             


Val Cys Ala Leu Ser Glu Ala Asp Leu Ile Glu Phe Pro Cys Asp Arg 
    770                 775                 780                 


Phe Met Asp Ser Thr Gly Gly Gly Thr Ser Gly Ser Leu Arg Arg Glu 
785                 790                 795                 800 


Asp His Leu Leu Gln Arg Phe Ala Asp 
                805                 


<210>  3
<211>  799
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Leu Asn Phe Tyr Lys Ile Pro Asp Asn Leu Pro Phe Ser Thr 
1               5                   10                  15      


Lys Asn Leu Asp Leu Ser Phe Asn Pro Leu Arg His Leu Gly Ser Tyr 
            20                  25                  30          


Ser Phe Phe Ser Phe Pro Glu Leu Gln Val Leu Asp Leu Ser Arg Cys 
        35                  40                  45              


Glu Ile Gln Thr Ile Glu Asp Gly Ala Tyr Gln Ser Leu Ser His Leu 
    50                  55                  60                  


Ser Thr Leu Ile Leu Thr Gly Asn Pro Ile Gln Ser Leu Ala Leu Gly 
65                  70                  75                  80  


Ala Phe Ser Gly Leu Ser Ser Leu Gln Lys Leu Val Ala Val Glu Thr 
                85                  90                  95      


Asn Leu Ala Ser Leu Glu Asn Phe Pro Ile Gly His Leu Lys Thr Leu 
            100                 105                 110         


Lys Glu Leu Asn Val Ala His Asn Leu Ile Gln Ser Phe Lys Leu Pro 
        115                 120                 125             


Glu Tyr Phe Ser Asn Leu Thr Asn Leu Glu His Leu Asp Leu Ser Ser 
    130                 135                 140                 


Asn Lys Ile Gln Ser Ile Tyr Cys Thr Asp Leu Arg Val Leu His Gln 
145                 150                 155                 160 


Met Pro Leu Leu Asn Leu Ser Leu Asp Leu Ser Leu Asn Pro Met Asn 
                165                 170                 175     


Phe Ile Gln Pro Gly Ala Phe Lys Glu Ile Arg Leu His Lys Leu Thr 
            180                 185                 190         


Leu Arg Asn Asn Phe Asp Ser Leu Asn Val Met Lys Thr Cys Ile Gln 
        195                 200                 205             


Gly Leu Ala Gly Leu Glu Val His Arg Leu Val Leu Gly Glu Phe Arg 
    210                 215                 220                 


Asn Glu Gly Asn Leu Glu Lys Phe Asp Lys Ser Ala Leu Glu Gly Leu 
225                 230                 235                 240 


Cys Asn Leu Thr Ile Glu Glu Phe Arg Leu Ala Tyr Leu Asp Tyr Tyr 
                245                 250                 255     


Leu Asp Asp Ile Ile Asp Leu Phe Asn Cys Leu Thr Asn Val Ser Ser 
            260                 265                 270         


Phe Ser Leu Val Ser Val Thr Ile Glu Arg Val Lys Asp Phe Ser Tyr 
        275                 280                 285             


Asn Phe Gly Trp Gln His Leu Glu Leu Val Asn Cys Lys Phe Gly Gln 
    290                 295                 300                 


Phe Pro Thr Leu Lys Leu Lys Ser Leu Lys Arg Leu Thr Phe Thr Ser 
305                 310                 315                 320 


Asn Lys Gly Gly Asn Ala Phe Ser Glu Val Asp Leu Pro Ser Leu Glu 
                325                 330                 335     


Phe Leu Asp Leu Ser Arg Asn Gly Leu Ser Phe Lys Gly Cys Cys Ser 
            340                 345                 350         


Gln Ser Asp Phe Gly Thr Thr Ser Leu Lys Tyr Leu Asp Leu Ser Phe 
        355                 360                 365             


Asn Gly Val Ile Thr Met Ser Ser Asn Phe Leu Gly Leu Glu Gln Leu 
    370                 375                 380                 


Glu His Leu Asp Phe Gln His Ser Asn Leu Lys Gln Met Ser Glu Phe 
385                 390                 395                 400 


Ser Val Phe Leu Ser Leu Arg Asn Leu Ile Tyr Leu Asp Ile Ser His 
                405                 410                 415     


Thr His Thr Arg Val Ala Phe Asn Gly Ile Phe Asn Gly Leu Ser Ser 
            420                 425                 430         


Leu Glu Val Leu Lys Met Ala Gly Asn Ser Phe Gln Glu Asn Phe Leu 
        435                 440                 445             


Pro Asp Ile Phe Thr Glu Leu Arg Asn Leu Thr Phe Leu Asp Leu Ser 
    450                 455                 460                 


Gln Cys Gln Leu Glu Gln Leu Ser Pro Thr Ala Phe Asn Ser Leu Ser 
465                 470                 475                 480 


Ser Leu Gln Val Leu Asn Met Ser His Asn Asn Phe Phe Ser Leu Asp 
                485                 490                 495     


Thr Phe Pro Tyr Lys Cys Leu Asn Ser Leu Gln Val Leu Asp Tyr Ser 
            500                 505                 510         


Leu Asn His Ile Met Thr Ser Lys Lys Gln Glu Leu Gln His Phe Pro 
        515                 520                 525             


Ser Ser Leu Ala Phe Leu Asn Leu Thr Gln Asn Asp Phe Ala Cys Thr 
    530                 535                 540                 


Cys Glu His Gln Ser Phe Leu Gln Trp Ile Lys Asp Gln Arg Gln Leu 
545                 550                 555                 560 


Leu Val Glu Val Glu Arg Met Glu Cys Ala Thr Pro Ser Asp Lys Gln 
                565                 570                 575     


Gly Met Pro Val Leu Ser Leu Asn Ile Thr Cys Gln Met Asn Lys Thr 
            580                 585                 590         


Ile Ile Gly Val Ser Val Leu Ser Val Leu Val Val Ser Val Val Ala 
        595                 600                 605             


Val Leu Val Tyr Lys Phe Tyr Phe His Leu Met Leu Leu Ala Gly Cys 
    610                 615                 620                 


Ile Lys Tyr Gly Arg Gly Glu Asn Ile Tyr Asp Ala Phe Val Ile Tyr 
625                 630                 635                 640 


Ser Ser Gln Asp Glu Asp Trp Val Arg Asn Glu Leu Val Lys Asn Leu 
                645                 650                 655     


Glu Glu Gly Val Pro Pro Phe Gln Leu Cys Leu His Tyr Arg Asp Phe 
            660                 665                 670         


Ile Pro Gly Val Ala Ile Ala Ala Asn Ile Ile His Glu Gly Phe His 
        675                 680                 685             


Lys Ser Arg Lys Val Ile Val Val Val Ser Gln His Phe Ile Gln Ser 
    690                 695                 700                 


Arg Trp Cys Ile Phe Glu Tyr Glu Ile Ala Gln Thr Trp Gln Phe Leu 
705                 710                 715                 720 


Ser Ser Arg Ala Gly Ile Ile Phe Ile Val Leu Gln Lys Val Glu Lys 
                725                 730                 735     


Thr Leu Leu Arg Gln Gln Val Glu Leu Tyr Arg Leu Leu Ser Arg Asn 
            740                 745                 750         


Thr Tyr Leu Glu Trp Glu Asp Ser Val Leu Gly Arg His Ile Phe Trp 
        755                 760                 765             


Arg Arg Leu Arg Lys Ala Leu Leu Asp Gly Lys Ser Trp Asn Pro Glu 
    770                 775                 780                 


Gly Thr Val Gly Thr Gly Cys Asn Trp Gln Glu Ala Thr Ser Ile 
785                 790                 795                 


<210>  4
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Arg Ala Ser Cys Leu Leu Leu Leu Leu Leu Pro Leu Val His 
1               5                   10                  15      


Val Ser Ala Thr Thr Pro Glu Pro Cys Glu Leu Asp Asp Glu Asp Phe 
            20                  25                  30          


Arg Cys Val Cys Asn Phe Ser Glu Pro Gln Pro Asp Trp Ser Glu Ala 
        35                  40                  45              


Phe Gln Cys Val Ser Ala Val Glu Val Glu Ile His Ala Gly Gly Leu 
    50                  55                  60                  


Asn Leu Glu Pro Phe Leu Lys Arg Val Asp Ala Asp Ala Asp Pro Arg 
65                  70                  75                  80  


Gln Tyr Ala Asp Thr Val Lys Ala Leu Arg Val Arg Arg Leu Thr Val 
                85                  90                  95      


Gly Ala Ala Gln Val Pro Ala Gln Leu Leu Val Gly Ala Leu Arg Val 
            100                 105                 110         


Leu Ala Tyr Ser Arg Leu Lys Glu Thr Leu Glu Asp Leu Lys Ile Thr 
        115                 120                 125             


Gly Thr Met Pro Pro Leu Pro Leu Glu Ala Thr Gly Leu Ala Leu Ser 
    130                 135                 140                 


Ser Leu Arg Leu Arg Asn Val Ser Trp Ala Thr Gly Arg Ser Trp Leu 
145                 150                 155                 160 


Ala Glu Leu Gln Gln Trp Leu Lys Pro Gly Leu Lys Val Leu Ser Ile 
                165                 170                 175     


Ala Gln Ala His Ser Pro Ala Phe Ser Cys Glu Gln Val Arg Ala Phe 
            180                 185                 190         


Pro Ala Leu Thr Ser Leu Asp Leu Ser Asp Asn Pro Gly Leu Gly Glu 
        195                 200                 205             


Arg Gly Leu Met Ala Ala Leu Cys Pro His Lys Phe Pro Ala Ile Gln 
    210                 215                 220                 


Asn Leu Ala Leu Arg Asn Thr Gly Met Glu Thr Pro Thr Gly Val Cys 
225                 230                 235                 240 


Ala Ala Leu Ala Ala Ala Gly Val Gln Pro His Ser Leu Asp Leu Ser 
                245                 250                 255     


His Asn Ser Leu Arg Ala Thr Val Asn Pro Ser Ala Pro Arg Cys Met 
            260                 265                 270         


Trp Ser Ser Ala Leu Asn Ser Leu Asn Leu Ser Phe Ala Gly Leu Glu 
        275                 280                 285             


Gln Val Pro Lys Gly Leu Pro Ala Lys Leu Arg Val Leu Asp Leu Ser 
    290                 295                 300                 


Cys Asn Arg Leu Asn Arg Ala Pro Gln Pro Asp Glu Leu Pro Glu Val 
305                 310                 315                 320 


Asp Asn Leu Thr Leu Asp Gly Asn Pro Phe Leu Val Pro Gly Thr Ala 
                325                 330                 335     


Leu Pro His Glu Gly Ser Met Asn Ser Gly Val Val Pro Ala Cys Ala 
            340                 345                 350         


Arg Ser Thr Leu Ser Val Gly Val Ser Gly Thr Leu Val Leu Leu Gln 
        355                 360                 365             


Gly Ala Arg Gly Phe Ala 
    370                 


<210>  5
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide: PCR forward KIAA0644 (TLR14) primer

<400>  5
gccttgcgcc tcctgctcgt ggtg                                              24


<210>  6
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide: Reverse KIAA0644 (TLR14) primer

<400>  6
ccaccgcgag agcttctcga aggt                                              24


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide: Forward GapDH primer

<400>  7
gaacgggaag cttgtcatca a                                                 21


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide: Reverse GapDH primer

<400>  8
ctaagcagtt ggtggtgcag                                                   20


