                         SEQUENCE LISTING

<110>  National Research Council of Canada
 
<120>  ANTAGONISTS OF LIGANDS AND USES THEREOF

<130>  NRC022EP

<160>  108   

<170>  PatentIn version 3.5

<210>  1
<211>  25
<212>  PRT
<213>  Homo Sapiens

<400>  1

Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
1               5                   10                  15      


Asp Asn Asn Gly Ala Val Lys Phe Pro 
            20                  25  


<210>  2
<211>  10
<212>  PRT
<213>  Homo Sapien

<400>  2

Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp 
1               5                   10  


<210>  3
<211>  50
<212>  PRT
<213>  Homo Sapiens

<400>  3

Ile Pro Pro His Val Gln Lys Ser Asp Val Glu Met Glu Ala Gln Lys 
1               5                   10                  15      


Asp Glu Ile Ile Cys Pro Ser Cys Asn Arg Thr Ala His Pro Leu Arg 
            20                  25                  30          


His Ile Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys 
        35                  40                  45              


Phe Pro 
    50  


<210>  4
<211>  8
<212>  PRT
<213>  Homo Sapiens

<400>  4

Ala Ala Leu Leu Pro Gly Ala Thr 
1               5               


<210>  5
<211>  14
<212>  PRT
<213>  Homo Sapiens

<400>  5

Pro Thr Thr Val Lys Ser Ser Pro Gly Leu Gly Pro Val Glu 
1               5                   10                  


<210>  6
<211>  7
<212>  PRT
<213>  Homo Sapiens

<400>  6

Ala Ile Leu Gly Arg Ser Glu 
1               5           


<210>  7
<211>  21
<212>  PRT
<213>  Homo Sapien

<400>  7

Glu Met Glu Val Thr Gln Pro Thr Ser Asn Pro Val Thr Pro Lys Pro 
1               5                   10                  15      


Pro Tyr Tyr Asn Ile 
            20      


<210>  8
<211>  8
<212>  PRT
<213>  Homo Sapiens

<400>  8

Ser Gly Arg Gly Glu Ala Glu Thr 
1               5               


<210>  9
<211>  17
<212>  PRT
<213>  Homo Sapiens

<400>  9

Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro 
1               5                   10                  15      


Thr 
    


<210>  10
<211>  31
<212>  PRT
<213>  Homo Sapiens

<400>  10

Gln Asn Leu Asp Ser Met Leu His Gly Thr Gly Met Lys Ser Asp Ser 
1               5                   10                  15      


Asp Gln Lys Lys Ser Glu Asn Gly Val Thr Leu Ala Pro Glu Asp 
            20                  25                  30      


<210>  11
<211>  13
<212>  PRT
<213>  Homo Sapiens

<400>  11

Pro Val Val Ile Gly Pro Phe Phe Asp Gly Ser Ile Arg 
1               5                   10              


<210>  12
<211>  101
<212>  PRT
<213>  Homo Sapiens

<400>  12

Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
1               5                   10                  15      


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
            20                  25                  30          


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
        35                  40                  45              


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
    50                  55                  60                  


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
65                  70                  75                  80  


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
                85                  90                  95      


Asp Asn Ile Ile Phe 
            100     


<210>  13
<211>  101
<212>  PRT
<213>  Homo Sapiens

<400>  13

Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
1               5                   10                  15      


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
            20                  25                  30          


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
        35                  40                  45              


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
    50                  55                  60                  


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
65                  70                  75                  80  


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
                85                  90                  95      


Asp Asn Ile Ile Phe 
            100     


<210>  14
<211>  79
<212>  PRT
<213>  Homo Sapiens

<400>  14

Ala Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys 
1               5                   10                  15      


Val Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys 
            20                  25                  30          


Val Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg 
        35                  40                  45              


Asp Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr 
    50                  55                  60                  


Thr Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu 
65                  70                  75                  


<210>  15
<211>  92
<212>  PRT
<213>  Homo Sapiens

<400>  15

Thr Gln Glu Cys Leu Phe Phe Asn Ala Asn Trp Glu Lys Asp Arg Thr 
1               5                   10                  15      


Asn Gln Thr Gly Val Glu Pro Cys Tyr Gly Asp Lys Asp Lys Arg Arg 
            20                  25                  30          


His Cys Phe Ala Thr Trp Lys Asn Ile Ser Gly Ser Ile Glu Ile Val 
        35                  40                  45              


Lys Gln Gly Cys Trp Leu Asp Asp Ile Asn Cys Tyr Asp Arg Thr Asp 
    50                  55                  60                  


Cys Val Glu Lys Lys Asp Ser Pro Glu Val Tyr Phe Cys Cys Cys Glu 
65                  70                  75                  80  


Gly Asn Met Cys Asn Glu Lys Phe Ser Tyr Phe Pro 
                85                  90          


<210>  16
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  16

Arg Glu Cys Ile Tyr Tyr Asn Ala Asn Trp Glu Leu Glu Arg Thr Asn 
1               5                   10                  15      


Gln Ser Gly Leu Glu Arg Cys Glu Gly Glu Gln Asp Lys Arg Leu His 
            20                  25                  30          


Cys Tyr Ala Ser Trp Arg Asn Ser Ser Gly Thr Ile Glu Leu Val Lys 
        35                  40                  45              


Lys Gly Cys Trp Leu Asp Asp Phe Asn Cys Tyr Asp Arg Gln Glu Cys 
    50                  55                  60                  


Val Ala Thr Glu Glu Asn Pro Gln Val Tyr Phe Cys Cys Cys Glu Gly 
65                  70                  75                  80  


Asn Phe Cys Asn Glu Arg Phe Thr His Leu Pro
                85                  90           
            


<210>  17
<211>  98
<212>  PRT
<213>  Homo Sapiens

<400>  17

Thr Leu Pro Phe Leu Lys Cys Tyr Cys Ser Gly His Cys Pro Asp Asp 
1               5                   10                  15      


Ala Ile Asn Asn Thr Cys Ile Thr Asn Gly His Cys Phe Ala Ile Ile 
            20                  25                  30          


Glu Glu Asp Asp Gln Gly Glu Thr Thr Leu Ala Ser Gly Cys Met Lys 
        35                  40                  45              


Tyr Glu Gly Ser Asp Phe Gln Cys Lys Asp Ser Pro Lys Ala Gln Leu 
    50                  55                  60                  


Arg Arg Thr Ile Glu Cys Cys Arg Thr Asn Leu Cys Asn Gln Tyr Leu 
65                  70                  75                  80  


Gln Pro Thr Leu Pro  
                85        


<210>  18
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  18

Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Ile Pro Pro His Val Gln 
1               5                   10                  15      


Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val 
            20                  25                  30          


Lys Phe Pro 
        35  


<210>  19
<211>  60
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide

<400>  19

Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Ile Pro Pro His Val Gln 
1               5                   10                  15      


Lys Ser Asp Val Glu Met Glu Ala Gln Lys Asp Glu Ile Ile Cys Pro 
            20                  25                  30          


Ser Cys Asn Arg Thr Ala His Pro Leu Arg His Ile Asn Asn Asp Met 
        35                  40                  45              


Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
    50                  55                  60  


<210>  20
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  20

Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro 
1               5                   10                  15      


Thr Ser Gly Arg Gly Glu Ala Glu Thr 
            20                  25  


<210>  21
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  21

Pro Val Val Ile Gly Pro Phe Phe Asp Gly Ser Ile Arg Gln Asn Leu 
1               5                   10                  15      


Asp Ser Met Leu His Gly Thr Gly Met Lys Ser Asp Ser Asp Gln Lys 
            20                  25                  30          


Lys Ser Glu Asn Gly Val Thr Leu Ala Pro Glu Asp 
        35                  40                  


<210>  22
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  22

Pro Val Val Ile Gly Pro Phe Phe Asp Gly Ser Ile Arg Gly Asn Leu 
1               5                   10                  15      


Asp Ser Met Leu His Gly Thr Gly Met Lys Ser Asp Ser Asp Gln Lys 
            20                  25                  30          


Lys Ser Glu Asn Gly Val Thr Leu Ala Pro Glu Asp 
        35                  40                  


<210>  23
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  23

Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Gly Pro Pro His Val Gln 
1               5                   10                  15      


Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val 
            20                  25                  30          


Lys Phe Pro 
        35  


<210>  24
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  24

Glu Ala Gly Gly Pro Glu Val Thr Gly Glu Pro Pro Pro Thr Ala Pro 
1               5                   10                  15      


Thr Ser Gly Arg Gly Glu Ala Glu Thr 
            20                  25  


<210>  25
<211>  60
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide

<400>  25

Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Arg His Val Gln 
1               5                   10                  15      


Lys Ser Asp Val Glu Met Glu Ala Gln Lys Asp Glu Ile Ile Cys Pro 
            20                  25                  30          


Ser Cys Asn Arg Thr Ala His Pro Leu Arg His Ile Asn Asn Asp Met 
        35                  40                  45              


Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
    50                  55                  60  


<210>  26
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  26

Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Pro His Val Gln 
1               5                   10                  15      


Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val 
            20                  25                  30          


Lys Phe Pro 
        35  


<210>  27
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  27

Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Arg His Val Gln 
1               5                   10                  15      


Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val 
            20                  25                  30          


Lys Phe Pro 
        35  


<210>  28
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  28

Ser Glu Glu Tyr Asn Thr Ser Asn Pro Ser Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Met Glu Ala Gln Lys Asp Glu Ile Ile Cys Pro 
            20                  25                  30          


Ser Cys Asn Arg Thr Ala His Pro Leu Arg His Ile Asn Asn Asp Met 
        35                  40                  45              


Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
    50                  55                  60  


<210>  29
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  29

Ser Glu Glu Tyr Asn Thr Ser Asn Pro Ser Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val 
            20                  25                  30          


Lys Phe Pro 
        35  


<210>  30
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  30

Ser Glu Glu Tyr Asn Thr Ser Asn Pro Ser Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val 
            20                  25                  30          


Lys Phe Pro 
        35  


<210>  31
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  31

Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Ile Pro Pro His Val Gln 
1               5                   10                  15      


Lys Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Asn Asn Asp Met 
        35                  40                  45              


Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
    50                  55                  60  


<210>  32
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  32

Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Asn Asn Asp Met 
        35                  40                  45              


Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
    50                  55                  60  


<210>  33
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  33

Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Ile Pro Pro His Val Gln 
1               5                   10                  15      


Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val 
            20                  25                  30          


Lys Phe Pro 
        35  


<210>  34
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  34

Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Ile Pro Pro His Val Gln 
1               5                   10                  15      


Lys Ser Val Asn Asn Asp Met Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


<210>  35
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  35

Ser Glu Glu Tyr Asn Thr Ser Asn Pro Pro His Val Gln Lys Ser Val 
1               5                   10                  15      


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
            20                  25                  30          


<210>  36
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  36

Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile 
            20                  25                  30          


Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40              


<210>  37
<211>  47
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic polypeptide

<400>  37

Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Ser Ile Pro Pro His Val Gln Lys Ser Val Asn 
            20                  25                  30          


Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45          


<210>  38
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  38

Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Ile Pro Pro His Val Gln 
1               5                   10                  15      


Lys Ser Asp Val Glu Met Glu Ala Gln Lys Asp Glu Ile Ile Cys Pro 
            20                  25                  30          


Ser Cys Asn Arg Thr Ala His Pro Leu Arg His Ile Asn Asn Asp Met 
        35                  40                  45              


Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
    50                  55                  60  


<210>  39
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  39

Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Ile Pro Pro His Val Gln 
1               5                   10                  15      


Lys Ser Asp Val Glu Met Glu Ala Gln Lys Asp Glu Arg Thr Ala His 
            20                  25                  30          


Pro Leu Arg His Ile Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly 
        35                  40                  45              


Ala Val Lys Phe Pro 
    50              


<210>  40
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  40

Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro 
1               5                   10                  15      


Thr Ser Gly Arg Gly Glu Ala Glu Thr 
            20                  25  


<210>  41
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  41

Glu Ala Gly Gly Pro Glu Val Thr Tyr Glu Pro Pro Pro Thr Ala Pro 
1               5                   10                  15      


Thr Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Gly Arg Gly Glu 
            20                  25                  30          


Ala Glu Thr 
        35  


<210>  42
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  42

Pro Val Val Ile Gly Pro Phe Phe Asp Gly Ser Ile Arg Gln Asn Leu 
1               5                   10                  15      


Asp Ser Met Leu His Gly Thr Gly Met Lys Ser Asp Ser Asp Gln Lys 
            20                  25                  30          


Lys Ser Glu Asn Gly Val Thr Leu Ala Pro Glu Asp 
        35                  40                  


<210>  43
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  43

Pro Val Val Ile Gly Pro Asp Gly Ser Ile Arg Gln Asn Leu Asp Ser 
1               5                   10                  15      


His Gly Thr Gly Met Lys Ser Asp Ser Asp Gln Lys Lys Ser Glu Asn 
            20                  25                  30          


Gly Val Thr Leu Ala Pro Glu Asp 
        35                  40  


<210>  44
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  44

Ala Ala Leu Leu Pro Gly Ala Thr Ala Leu Gln Cys Phe Cys His Leu 
1               5                   10                  15      


Cys Thr Lys Asp Asn Phe Thr Cys Val Thr Asp Gly Leu Cys Phe Val 
            20                  25                  30          


Ser Val Thr Glu Thr Thr Asp Lys Val Ile His Asn Ser Met Cys Ile 
        35                  40                  45              


Ala Glu Ile Asp Leu Ile Pro Arg Asp Arg Pro Phe Val Cys Ala Pro 
    50                  55                  60                  


Ser Ser Lys Thr Gly Ser Val Thr Thr Thr Tyr Cys Cys Asn Gln Asp 
65                  70                  75                  80  


His Cys Asn Lys Ile Glu Leu Pro Thr Thr Val Thr Asp Asn Asn Gly 
                85                  90                  95      


Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser 
            100                 105                 110         


Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser 
        115                 120                 125             


Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn 
    130                 135                 140                 


Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro 
145                 150                 155                 160 


Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met 
                165                 170                 175     


Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser 
            180                 185                 190         


Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr 
        195                 200                 205             


Ser Asn Pro Asp 
    210         


<210>  45
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  45

Ala Ala Leu Leu Pro Gly Ala Thr Ala Leu Gln Cys Phe Cys His Leu 
1               5                   10                  15      


Cys Thr Lys Asp Asn Phe Thr Cys Val Thr Asp Gly Leu Cys Phe Val 
            20                  25                  30          


Ser Val Thr Glu Thr Thr Asp Lys Val Ile His Asn Ser Met Cys Ile 
        35                  40                  45              


Ala Glu Ile Asp Leu Ile Pro Arg Asp Arg Pro Phe Val Cys Ala Pro 
    50                  55                  60                  


Ser Ser Lys Thr Gly Ser Val Thr Thr Thr Tyr Cys Cys Asn Gln Asp 
65                  70                  75                  80  


His Cys Asn Lys Ile Glu Leu Gly Gly Gly Gly Gly Gly Gly Asn Gly 
                85                  90                  95      


Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser 
            100                 105                 110         


Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser 
        115                 120                 125             


Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn 
    130                 135                 140                 


Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro 
145                 150                 155                 160 


Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met 
                165                 170                 175     


Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser 
            180                 185                 190         


Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr 
        195                 200                 205             


Ser Asn Pro Asp 
    210         


<210>  46
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  46

Ala Ala Leu Leu Pro Gly Ala Thr Ala Leu Gln Cys Phe Cys His Leu 
1               5                   10                  15      


Cys Thr Lys Asp Asn Phe Thr Cys Val Thr Asp Gly Leu Cys Phe Val 
            20                  25                  30          


Ser Val Thr Glu Thr Thr Asp Lys Val Ile His Asn Ser Met Cys Ile 
        35                  40                  45              


Ala Glu Ile Asp Leu Ile Pro Arg Asp Arg Pro Phe Val Cys Ala Pro 
    50                  55                  60                  


Ser Ser Lys Thr Gly Ser Val Thr Thr Thr Tyr Cys Cys Asn Gln Asp 
65                  70                  75                  80  


His Cys Asn Lys Ile Glu Leu Pro Thr Thr Val Thr Asp Asn Asn Gly 
                85                  90                  95      


Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser 
            100                 105                 110         


Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser 
        115                 120                 125             


Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn 
    130                 135                 140                 


Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro 
145                 150                 155                 160 


Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met 
                165                 170                 175     


Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser 
            180                 185                 190         


Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr 
        195                 200                 205             


Ser Asn Pro Asp Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
    210                 215                 220                 


Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
225                 230                 235                 240 


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
                245                 250                 255     


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
            260                 265                 270         


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
        275                 280                 285             


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
    290                 295                 300                 


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
305                 310                 315                 320 


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
                325                 330                 335     


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
            340                 345                 350         


Glu Tyr Asn Thr Ser Asn Pro Asp 
        355                 360 


<210>  47
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  47

Ala Ala Leu Leu Pro Gly Ala Thr Ala Leu Gln Cys Phe Cys His Leu 
1               5                   10                  15      


Cys Thr Lys Asp Asn Phe Thr Cys Val Thr Asp Gly Leu Cys Phe Val 
            20                  25                  30          


Ser Val Thr Glu Thr Thr Asp Lys Val Ile His Asn Ser Met Cys Ile 
        35                  40                  45              


Ala Glu Ile Asp Leu Ile Pro Arg Asp Arg Pro Phe Val Cys Ala Pro 
    50                  55                  60                  


Ser Ser Lys Thr Gly Ser Val Thr Thr Thr Tyr Cys Cys Asn Gln Asp 
65                  70                  75                  80  


His Cys Asn Lys Ile Glu Leu Pro Thr Thr Val Thr Asp Asn Asn Gly 
                85                  90                  95      


Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser 
            100                 105                 110         


Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser 
        115                 120                 125             


Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn 
    130                 135                 140                 


Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro 
145                 150                 155                 160 


Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met 
                165                 170                 175     


Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser 
            180                 185                 190         


Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr 
        195                 200                 205             


Ser Asn Pro Asp Ile Pro Pro His Val Gln Lys Ser Asp Val Glu Met 
    210                 215                 220                 


Glu Ala Gln Lys Asp Glu Ile Ile Cys Pro Ser Cys Asn Arg Thr Ala 
225                 230                 235                 240 


His Pro Leu Arg His Ile Asn Asn Asp Met Ile Val Thr Asp Asn Asn 
                245                 250                 255     


Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe 
            260                 265                 270         


Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr 
        275                 280                 285             


Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys 
    290                 295                 300                 


Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu 
305                 310                 315                 320 


Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile 
                325                 330                 335     


Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys 
            340                 345                 350         


Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn 
        355                 360                 365             


Thr Ser Asn Pro Asp 
    370             


<210>  48
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  48

Ala Ala Leu Leu Pro Gly Ala Thr Ala Leu Gln Cys Phe Cys His Leu 
1               5                   10                  15      


Cys Thr Lys Asp Asn Phe Thr Cys Val Thr Asp Gly Leu Cys Phe Val 
            20                  25                  30          


Ser Val Thr Glu Thr Thr Asp Lys Val Ile His Asn Ser Met Cys Ile 
        35                  40                  45              


Ala Glu Ile Asp Leu Ile Pro Arg Asp Arg Pro Phe Val Cys Ala Pro 
    50                  55                  60                  


Ser Ser Lys Thr Gly Ser Val Thr Thr Thr Tyr Cys Cys Asn Gln Asp 
65                  70                  75                  80  


His Cys Asn Lys Ile Glu Leu Pro Thr Thr Val Thr Asp Asn Asn Gly 
                85                  90                  95      


Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser 
            100                 105                 110         


Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser 
        115                 120                 125             


Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn 
    130                 135                 140                 


Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro 
145                 150                 155                 160 


Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met 
                165                 170                 175     


Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser 
            180                 185                 190         


Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr 
        195                 200                 205             


Ser Asn Pro Asp Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Gly Ser Ala Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp 
                245                 250                 255     


Asn Phe Thr Cys Val Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu 
            260                 265                 270         


Thr Thr Asp Lys Val Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp 
        275                 280                 285             


Leu Ile Pro Arg Asp Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr 
    290                 295                 300                 


Gly Ser Val Thr Thr Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys 
305                 310                 315                 320 


Ile Glu Leu Pro Thr Thr Val Thr Asp Asn Asn Gly Ala Val Lys Phe 
                325                 330                 335     


Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn 
            340                 345                 350         


Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys 
        355                 360                 365             


Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile 
    370                 375                 380                 


Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe 
385                 390                 395                 400 


Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys 
                405                 410                 415     


Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys 
            420                 425                 430         


Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp 
        435                 440                 445             


<210>  49
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  49

Ala Ala Leu Leu Pro Gly Ala Thr Ala Leu Gln Cys Phe Cys His Leu 
1               5                   10                  15      


Cys Thr Lys Asp Asn Phe Thr Cys Val Thr Asp Gly Leu Cys Phe Val 
            20                  25                  30          


Ser Val Thr Glu Thr Thr Asp Lys Val Ile His Asn Ser Met Cys Ile 
        35                  40                  45              


Ala Glu Ile Asp Leu Ile Pro Arg Asp Arg Pro Phe Val Cys Ala Pro 
    50                  55                  60                  


Ser Ser Lys Thr Gly Ser Val Thr Thr Thr Tyr Cys Cys Asn Gln Asp 
65                  70                  75                  80  


His Cys Asn Lys Ile Glu Leu Gly Gly Gly Gly Gly Gly Gly Asn Gly 
                85                  90                  95      


Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser 
            100                 105                 110         


Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser 
        115                 120                 125             


Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn 
    130                 135                 140                 


Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro 
145                 150                 155                 160 


Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met 
                165                 170                 175     


Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser 
            180                 185                 190         


Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr 
        195                 200                 205             


Ser Asn Pro Asp Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Gly Ser Ala Leu Gln Cys Phe Cys His Leu Cys Thr Lys Asp 
                245                 250                 255     


Asn Phe Thr Cys Val Thr Asp Gly Leu Cys Phe Val Ser Val Thr Glu 
            260                 265                 270         


Thr Thr Asp Lys Val Ile His Asn Ser Met Cys Ile Ala Glu Ile Asp 
        275                 280                 285             


Leu Ile Pro Arg Asp Arg Pro Phe Val Cys Ala Pro Ser Ser Lys Thr 
    290                 295                 300                 


Gly Ser Val Thr Thr Thr Tyr Cys Cys Asn Gln Asp His Cys Asn Lys 
305                 310                 315                 320 


Ile Glu Leu Gly Gly Gly Gly Gly Gly Gly Asn Gly Ala Val Lys Phe 
                325                 330                 335     


Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn 
            340                 345                 350         


Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys 
        355                 360                 365             


Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile 
    370                 375                 380                 


Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe 
385                 390                 395                 400 


Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys 
                405                 410                 415     


Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys 
            420                 425                 430         


Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp 
        435                 440                 445             


<210>  50
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  50

Ala Ala Leu Leu Pro Gly Ala Thr Ala Leu Gln Cys Phe Cys His Leu 
1               5                   10                  15      


Cys Thr Lys Asp Asn Phe Thr Cys Val Thr Asp Gly Leu Cys Phe Val 
            20                  25                  30          


Ser Val Thr Glu Thr Thr Asp Lys Val Ile His Asn Ser Met Cys Ile 
        35                  40                  45              


Ala Glu Ile Asp Leu Ile Pro Arg Asp Arg Pro Phe Val Cys Ala Pro 
    50                  55                  60                  


Ser Ser Lys Thr Gly Ser Val Thr Thr Thr Tyr Cys Cys Asn Gln Asp 
65                  70                  75                  80  


His Cys Asn Lys Ile Glu Leu Gly Gly Gly Gly Gly Gly Gly Asn Gly 
                85                  90                  95      


Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser 
            100                 105                 110         


Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser 
        115                 120                 125             


Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn 
    130                 135                 140                 


Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro 
145                 150                 155                 160 


Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met 
                165                 170                 175     


Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser 
            180                 185                 190         


Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr 
        195                 200                 205             


Ser Asn Pro Asp Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
    210                 215                 220                 


Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
225                 230                 235                 240 


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
                245                 250                 255     


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
            260                 265                 270         


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
        275                 280                 285             


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
    290                 295                 300                 


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
305                 310                 315                 320 


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
                325                 330                 335     


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
            340                 345                 350         


Glu Tyr Asn Thr Ser Asn Pro Asp Gly Gly Gly Ser Gly Gly Gly Ser 
        355                 360                 365             


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Ala Leu Gln Cys 
    370                 375                 380                 


Phe Cys His Leu Cys Thr Lys Asp Asn Phe Thr Cys Val Thr Asp Gly 
385                 390                 395                 400 


Leu Cys Phe Val Ser Val Thr Glu Thr Thr Asp Lys Val Ile His Asn 
                405                 410                 415     


Ser Met Cys Ile Ala Glu Ile Asp Leu Ile Pro Arg Asp Arg Pro Phe 
            420                 425                 430         


Val Cys Ala Pro Ser Ser Lys Thr Gly Ser Val Thr Thr Thr Tyr Cys 
        435                 440                 445             


Cys Asn Gln Asp His Cys Asn Lys Ile Glu Leu Pro Thr Thr Val Lys 
    450                 455                 460                 


Ser Ser Pro Gly Leu Gly Pro Val Glu 
465                 470             


<210>  51
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  51

Ala Ala Leu Leu Pro Gly Ala Thr Ala Leu Gln Cys Phe Cys His Leu 
1               5                   10                  15      


Cys Thr Lys Asp Asn Phe Thr Cys Val Thr Asp Gly Leu Cys Phe Val 
            20                  25                  30          


Ser Val Thr Glu Thr Thr Asp Lys Val Ile His Asn Ser Met Cys Ile 
        35                  40                  45              


Ala Glu Ile Asp Leu Ile Pro Arg Asp Arg Pro Phe Val Cys Ala Pro 
    50                  55                  60                  


Ser Ser Lys Thr Gly Ser Val Thr Thr Thr Tyr Cys Cys Asn Gln Asp 
65                  70                  75                  80  


His Cys Asn Lys Ile Glu Leu Pro Thr Thr Val Lys Ser Ser Pro Gly 
                85                  90                  95      


Leu Gly Pro Val Glu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Ser Gly Gly Gly Ser Ala Leu Gln Cys Phe Cys His 
        115                 120                 125             


Leu Cys Thr Lys Asp Asn Phe Thr Cys Val Thr Asp Gly Leu Cys Phe 
    130                 135                 140                 


Val Ser Val Thr Glu Thr Thr Asp Lys Val Ile His Asn Ser Met Cys 
145                 150                 155                 160 


Ile Ala Glu Ile Asp Leu Ile Pro Arg Asp Arg Pro Phe Val Cys Ala 
                165                 170                 175     


Pro Ser Ser Lys Thr Gly Ser Val Thr Thr Thr Tyr Cys Cys Asn Gln 
            180                 185                 190         


Asp His Cys Asn Lys Ile Glu Leu Gly Gly Gly Gly Gly Gly Gly Asn 
        195                 200                 205             


Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe 
    210                 215                 220                 


Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr 
225                 230                 235                 240 


Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys 
                245                 250                 255     


Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu 
            260                 265                 270         


Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile 
        275                 280                 285             


Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys 
    290                 295                 300                 


Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn 
305                 310                 315                 320 


Thr Ser Asn Pro Asp Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
                325                 330                 335     


Ser Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val 
            340                 345                 350         


Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys 
        355                 360                 365             


Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn 
    370                 375                 380                 


Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala 
385                 390                 395                 400 


Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His 
                405                 410                 415     


Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser 
            420                 425                 430         


Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe 
        435                 440                 445             


Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser 
    450                 455                 460                 


Glu Glu Tyr Asn Thr Ser Asn Pro Asp 
465                 470             


<210>  52
<211>  213
<212>  PRT
<213>  TR-I/II-v1a

<400>  52

Ala Ala Leu Leu Pro Gly Ala Thr Ala Leu Gln Cys Phe Cys His Leu 
1               5                   10                  15      


Cys Thr Lys Asp Asn Phe Thr Cys Val Thr Asp Gly Leu Cys Phe Val 
            20                  25                  30          


Ser Val Thr Glu Thr Thr Asp Lys Val Ile His Asn Ser Met Cys Ile 
        35                  40                  45              


Ala Glu Ile Asp Leu Ile Pro Arg Asp Arg Pro Phe Val Cys Ala Pro 
    50                  55                  60                  


Ser Ser Lys Thr Gly Ser Val Thr Thr Thr Tyr Cys Cys Asn Gln Asp 
65                  70                  75                  80  


His Cys Asn Lys Ile Glu Leu Pro Thr Thr Val Val Thr Asp Asn Asn 
                85                  90                  95      


Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe 
            100                 105                 110         


Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr 
        115                 120                 125             


Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys 
    130                 135                 140                 


Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu 
145                 150                 155                 160 


Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile 
                165                 170                 175     


Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys 
            180                 185                 190         


Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn 
        195                 200                 205             


Thr Ser Asn Pro Asp 
    210             


<210>  53
<211>  214
<212>  PRT
<213>  TR-I/II-v1b

<400>  53

Ala Ala Leu Leu Pro Gly Ala Thr Ala Leu Gln Cys Phe Cys His Leu 
1               5                   10                  15      


Cys Thr Lys Asp Asn Phe Thr Cys Val Thr Asp Gly Leu Cys Phe Val 
            20                  25                  30          


Ser Val Thr Glu Thr Thr Asp Lys Val Ile His Asn Ser Met Cys Ile 
        35                  40                  45              


Ala Glu Ile Asp Leu Ile Pro Arg Asp Arg Pro Phe Val Cys Ala Pro 
    50                  55                  60                  


Ser Ser Lys Thr Gly Ser Val Thr Thr Thr Tyr Cys Cys Asn Gln Asp 
65                  70                  75                  80  


His Cys Asn Lys Ile Glu Leu Pro Thr Thr Val Lys Ser Ser Pro Gly 
                85                  90                  95      


Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg 
            100                 105                 110         


Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile 
        115                 120                 125             


Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg 
    130                 135                 140                 


Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys 
145                 150                 155                 160 


Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys 
                165                 170                 175     


Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser 
            180                 185                 190         


Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr 
        195                 200                 205             


Asn Thr Ser Asn Pro Asp 
    210                 


<210>  54
<211>  213
<212>  PRT
<213>  TR-I/II-v1c

<400>  54

Ala Ala Leu Leu Pro Gly Ala Thr Ala Leu Gln Cys Phe Cys His Leu 
1               5                   10                  15      


Cys Thr Lys Asp Asn Phe Thr Cys Val Thr Asp Gly Leu Cys Phe Val 
            20                  25                  30          


Ser Val Thr Glu Thr Thr Asp Lys Val Ile His Asn Ser Met Cys Ile 
        35                  40                  45              


Ala Glu Ile Asp Leu Ile Pro Arg Asp Arg Pro Phe Val Cys Ala Pro 
    50                  55                  60                  


Ser Ser Lys Thr Gly Ser Val Thr Thr Thr Tyr Cys Cys Asn Gln Asp 
65                  70                  75                  80  


His Cys Asn Lys Ile Glu Leu Asn Asp Met Ile Val Thr Asp Asn Asn 
                85                  90                  95      


Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe 
            100                 105                 110         


Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr 
        115                 120                 125             


Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys 
    130                 135                 140                 


Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu 
145                 150                 155                 160 


Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile 
                165                 170                 175     


Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys 
            180                 185                 190         


Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn 
        195                 200                 205             


Thr Ser Asn Pro Asp 
    210             


<210>  55
<211>  221
<212>  PRT
<213>  ActR-IIa/BMPR-Ia-v1

<400>  55

Ala Ile Leu Gly Arg Ser Glu Thr Gln Glu Cys Leu Phe Phe Asn Ala 
1               5                   10                  15      


Asn Trp Glu Lys Asp Arg Thr Asn Gln Thr Gly Val Glu Pro Cys Tyr 
            20                  25                  30          


Gly Asp Lys Asp Lys Arg Arg His Cys Phe Ala Thr Trp Lys Asn Ile 
        35                  40                  45              


Ser Gly Ser Ile Glu Ile Val Lys Gln Gly Cys Trp Leu Asp Asp Ile 
    50                  55                  60                  


Asn Cys Tyr Asp Arg Thr Asp Cys Val Glu Lys Lys Asp Ser Pro Glu 
65                  70                  75                  80  


Val Tyr Phe Cys Cys Cys Glu Gly Asn Met Cys Asn Glu Lys Phe Ser 
                85                  90                  95      


Tyr Phe Pro Glu Met Glu Val Thr Gln Pro Thr Ser Asp Gln Lys Lys 
            100                 105                 110         


Ser Glu Asn Gly Val Thr Leu Ala Pro Glu Asp Thr Leu Pro Phe Leu 
        115                 120                 125             


Lys Cys Tyr Cys Ser Gly His Cys Pro Asp Asp Ala Ile Asn Asn Thr 
    130                 135                 140                 


Cys Ile Thr Asn Gly His Cys Phe Ala Ile Ile Glu Glu Asp Asp Gln 
145                 150                 155                 160 


Gly Glu Thr Thr Leu Ala Ser Gly Cys Met Lys Tyr Glu Gly Ser Asp 
                165                 170                 175     


Phe Gln Cys Lys Asp Ser Pro Lys Ala Gln Leu Arg Arg Thr Ile Glu 
            180                 185                 190         


Cys Cys Arg Thr Asn Leu Cys Asn Gln Tyr Leu Gln Pro Thr Leu Pro 
        195                 200                 205             


Pro Val Val Ile Gly Pro Phe Phe Asp Gly Ser Ile Arg 
    210                 215                 220     


<210>  56
<211>  223
<212>  PRT
<213>  ActR-IIa/BMPR-Ia-v1a

<400>  56

Ala Ile Leu Gly Arg Ser Glu Thr Gln Glu Cys Leu Phe Phe Asn Ala 
1               5                   10                  15      


Asn Trp Glu Lys Asp Arg Thr Asn Gln Thr Gly Val Glu Pro Cys Tyr 
            20                  25                  30          


Gly Asp Lys Asp Lys Arg Arg His Cys Phe Ala Thr Trp Lys Asn Ile 
        35                  40                  45              


Ser Gly Ser Ile Glu Ile Val Lys Gln Gly Cys Trp Leu Asp Asp Ile 
    50                  55                  60                  


Asn Cys Tyr Asp Arg Thr Asp Cys Val Glu Lys Lys Asp Ser Pro Glu 
65                  70                  75                  80  


Val Tyr Phe Cys Cys Cys Glu Gly Asn Met Cys Asn Glu Lys Phe Ser 
                85                  90                  95      


Tyr Phe Pro Glu Met Glu Val Thr Gln Pro Thr Ser Asp Ser Asp Gln 
            100                 105                 110         


Lys Lys Ser Glu Asn Gly Val Thr Leu Ala Pro Glu Asp Thr Leu Pro 
        115                 120                 125             


Phe Leu Lys Cys Tyr Cys Ser Gly His Cys Pro Asp Asp Ala Ile Asn 
    130                 135                 140                 


Asn Thr Cys Ile Thr Asn Gly His Cys Phe Ala Ile Ile Glu Glu Asp 
145                 150                 155                 160 


Asp Gln Gly Glu Thr Thr Leu Ala Ser Gly Cys Met Lys Tyr Glu Gly 
                165                 170                 175     


Ser Asp Phe Gln Cys Lys Asp Ser Pro Lys Ala Gln Leu Arg Arg Thr 
            180                 185                 190         


Ile Glu Cys Cys Arg Thr Asn Leu Cys Asn Gln Tyr Leu Gln Pro Thr 
        195                 200                 205             


Leu Pro Pro Val Val Ile Gly Pro Phe Phe Asp Gly Ser Ile Arg 
    210                 215                 220             


<210>  57
<211>  230
<212>  PRT
<213>  ActR-IIa/BMPR-Ia-v1b

<400>  57

Ala Ile Leu Gly Arg Ser Glu Thr Gln Glu Cys Leu Phe Phe Asn Ala 
1               5                   10                  15      


Asn Trp Glu Lys Asp Arg Thr Asn Gln Thr Gly Val Glu Pro Cys Tyr 
            20                  25                  30          


Gly Asp Lys Asp Lys Arg Arg His Cys Phe Ala Thr Trp Lys Asn Ile 
        35                  40                  45              


Ser Gly Ser Ile Glu Ile Val Lys Gln Gly Cys Trp Leu Asp Asp Ile 
    50                  55                  60                  


Asn Cys Tyr Asp Arg Thr Asp Cys Val Glu Lys Lys Asp Ser Pro Glu 
65                  70                  75                  80  


Val Tyr Phe Cys Cys Cys Glu Gly Asn Met Cys Asn Glu Lys Phe Ser 
                85                  90                  95      


Tyr Phe Pro Glu Met Glu Val Thr Gln Pro Thr Ser Asn Pro Val Thr 
            100                 105                 110         


Pro Lys Ser Asp Ser Asp Gln Lys Lys Ser Glu Asn Gly Val Thr Leu 
        115                 120                 125             


Ala Pro Glu Asp Thr Leu Pro Phe Leu Lys Cys Tyr Cys Ser Gly His 
    130                 135                 140                 


Cys Pro Asp Asp Ala Ile Asn Asn Thr Cys Ile Thr Asn Gly His Cys 
145                 150                 155                 160 


Phe Ala Ile Ile Glu Glu Asp Asp Gln Gly Glu Thr Thr Leu Ala Ser 
                165                 170                 175     


Gly Cys Met Lys Tyr Glu Gly Ser Asp Phe Gln Cys Lys Asp Ser Pro 
            180                 185                 190         


Lys Ala Gln Leu Arg Arg Thr Ile Glu Cys Cys Arg Thr Asn Leu Cys 
        195                 200                 205             


Asn Gln Tyr Leu Gln Pro Thr Leu Pro Pro Val Val Ile Gly Pro Phe 
    210                 215                 220                 


Phe Asp Gly Ser Ile Arg 
225                 230 


<210>  58
<211>  231
<212>  PRT
<213>  ActR-IIa/BMPR-Ia-v1c

<400>  58

Ala Ile Leu Gly Arg Ser Glu Thr Gln Glu Cys Leu Phe Phe Asn Ala 
1               5                   10                  15      


Asn Trp Glu Lys Asp Arg Thr Asn Gln Thr Gly Val Glu Pro Cys Tyr 
            20                  25                  30          


Gly Asp Lys Asp Lys Arg Arg His Cys Phe Ala Thr Trp Lys Asn Ile 
        35                  40                  45              


Ser Gly Ser Ile Glu Ile Val Lys Gln Gly Cys Trp Leu Asp Asp Ile 
    50                  55                  60                  


Asn Cys Tyr Asp Arg Thr Asp Cys Val Glu Lys Lys Asp Ser Pro Glu 
65                  70                  75                  80  


Val Tyr Phe Cys Cys Cys Glu Gly Asn Met Cys Asn Glu Lys Phe Ser 
                85                  90                  95      


Tyr Phe Pro Glu Met Glu Val Thr Gln Pro Thr Ser Asn Pro Val Thr 
            100                 105                 110         


Gly Met Lys Ser Asp Ser Asp Gln Lys Lys Ser Glu Asn Gly Val Thr 
        115                 120                 125             


Leu Ala Pro Glu Asp Thr Leu Pro Phe Leu Lys Cys Tyr Cys Ser Gly 
    130                 135                 140                 


His Cys Pro Asp Asp Ala Ile Asn Asn Thr Cys Ile Thr Asn Gly His 
145                 150                 155                 160 


Cys Phe Ala Ile Ile Glu Glu Asp Asp Gln Gly Glu Thr Thr Leu Ala 
                165                 170                 175     


Ser Gly Cys Met Lys Tyr Glu Gly Ser Asp Phe Gln Cys Lys Asp Ser 
            180                 185                 190         


Pro Lys Ala Gln Leu Arg Arg Thr Ile Glu Cys Cys Arg Thr Asn Leu 
        195                 200                 205             


Cys Asn Gln Tyr Leu Gln Pro Thr Leu Pro Pro Val Val Ile Gly Pro 
    210                 215                 220                 


Phe Phe Asp Gly Ser Ile Arg 
225                 230     


<210>  59
<211>  213
<212>  PRT
<213>  TR-I/II-v2a

<400>  59

Ala Ala Leu Leu Pro Gly Ala Thr Ala Leu Gln Cys Phe Cys His Leu 
1               5                   10                  15      


Cys Thr Lys Asp Asn Phe Thr Cys Val Thr Asp Gly Leu Cys Phe Val 
            20                  25                  30          


Ser Val Thr Glu Thr Thr Asp Lys Val Ile His Asn Ser Met Cys Ile 
        35                  40                  45              


Ala Glu Ile Asp Leu Ile Pro Arg Asp Arg Pro Phe Val Cys Ala Pro 
    50                  55                  60                  


Ser Ser Lys Thr Gly Ser Val Thr Thr Thr Tyr Cys Cys Asn Gln Asp 
65                  70                  75                  80  


His Cys Asn Lys Ile Glu Leu Gly Gly Gly Gly Gly Gly Gly Gly Asn 
                85                  90                  95      


Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe 
            100                 105                 110         


Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr 
        115                 120                 125             


Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys 
    130                 135                 140                 


Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu 
145                 150                 155                 160 


Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile 
                165                 170                 175     


Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys 
            180                 185                 190         


Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn 
        195                 200                 205             


Thr Ser Asn Pro Asp 
    210             


<210>  60
<211>  212
<212>  PRT
<213>  TR-I/II-v2b

<400>  60

Ala Ala Leu Leu Pro Gly Ala Thr Ala Leu Gln Cys Phe Cys His Leu 
1               5                   10                  15      


Cys Thr Lys Asp Asn Phe Thr Cys Val Thr Asp Gly Leu Cys Phe Val 
            20                  25                  30          


Ser Val Thr Glu Thr Thr Asp Lys Val Ile His Asn Ser Met Cys Ile 
        35                  40                  45              


Ala Glu Ile Asp Leu Ile Pro Arg Asp Arg Pro Phe Val Cys Ala Pro 
    50                  55                  60                  


Ser Ser Lys Thr Gly Ser Val Thr Thr Thr Tyr Cys Cys Asn Gln Asp 
65                  70                  75                  80  


His Cys Asn Lys Ile Glu Leu Gly Ser Gly Gly Gly Ser Gly Asn Gly 
                85                  90                  95      


Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser 
            100                 105                 110         


Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser 
        115                 120                 125             


Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn 
    130                 135                 140                 


Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro 
145                 150                 155                 160 


Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met 
                165                 170                 175     


Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser 
            180                 185                 190         


Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr 
        195                 200                 205             


Ser Asn Pro Asp 
    210         


<210>  61
<211>  213
<212>  PRT
<213>  TR-I/II-v2c

<400>  61

Ala Ala Leu Leu Pro Gly Ala Thr Ala Leu Gln Cys Phe Cys His Leu 
1               5                   10                  15      


Cys Thr Lys Asp Asn Phe Thr Cys Val Thr Asp Gly Leu Cys Phe Val 
            20                  25                  30          


Ser Val Thr Glu Thr Thr Asp Lys Val Ile His Asn Ser Met Cys Ile 
        35                  40                  45              


Ala Glu Ile Asp Leu Ile Pro Arg Asp Arg Pro Phe Val Cys Ala Pro 
    50                  55                  60                  


Ser Ser Lys Thr Gly Ser Val Thr Thr Thr Tyr Cys Cys Asn Gln Asp 
65                  70                  75                  80  


His Cys Asn Lys Ile Glu Leu Gly Gly Ser Gly Gly Ser Gly Gly Asn 
                85                  90                  95      


Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe 
            100                 105                 110         


Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr 
        115                 120                 125             


Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys 
    130                 135                 140                 


Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu 
145                 150                 155                 160 


Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile 
                165                 170                 175     


Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys 
            180                 185                 190         


Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn 
        195                 200                 205             


Thr Ser Asn Pro Asp 
    210             


<210>  62
<211>  221
<212>  PRT
<213>  ActR-IIa/BMPR-Ia-v2

<400>  62

Ala Ile Leu Gly Arg Ser Glu Thr Gln Glu Cys Leu Phe Phe Asn Ala 
1               5                   10                  15      


Asn Trp Glu Lys Asp Arg Thr Asn Gln Thr Gly Val Glu Pro Cys Tyr 
            20                  25                  30          


Gly Asp Lys Asp Lys Arg Arg His Cys Phe Ala Thr Trp Lys Asn Ile 
        35                  40                  45              


Ser Gly Ser Ile Glu Ile Val Lys Gln Gly Cys Trp Leu Asp Asp Ile 
    50                  55                  60                  


Asn Cys Tyr Asp Arg Thr Asp Cys Val Glu Lys Lys Asp Ser Pro Glu 
65                  70                  75                  80  


Val Tyr Phe Cys Cys Cys Glu Gly Asn Met Cys Asn Glu Lys Phe Ser 
                85                  90                  95      


Tyr Phe Pro Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
            100                 105                 110         


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Thr Leu Pro Phe Leu 
        115                 120                 125             


Lys Cys Tyr Cys Ser Gly His Cys Pro Asp Asp Ala Ile Asn Asn Thr 
    130                 135                 140                 


Cys Ile Thr Asn Gly His Cys Phe Ala Ile Ile Glu Glu Asp Asp Gln 
145                 150                 155                 160 


Gly Glu Thr Thr Leu Ala Ser Gly Cys Met Lys Tyr Glu Gly Ser Asp 
                165                 170                 175     


Phe Gln Cys Lys Asp Ser Pro Lys Ala Gln Leu Arg Arg Thr Ile Glu 
            180                 185                 190         


Cys Cys Arg Thr Asn Leu Cys Asn Gln Tyr Leu Gln Pro Thr Leu Pro 
        195                 200                 205             


Pro Val Val Ile Gly Pro Phe Phe Asp Gly Ser Ile Arg 
    210                 215                 220     


<210>  63
<211>  223
<212>  PRT
<213>  ActR-IIa/BMPR-Ia-v2a

<400>  63

Ala Ile Leu Gly Arg Ser Glu Thr Gln Glu Cys Leu Phe Phe Asn Ala 
1               5                   10                  15      


Asn Trp Glu Lys Asp Arg Thr Asn Gln Thr Gly Val Glu Pro Cys Tyr 
            20                  25                  30          


Gly Asp Lys Asp Lys Arg Arg His Cys Phe Ala Thr Trp Lys Asn Ile 
        35                  40                  45              


Ser Gly Ser Ile Glu Ile Val Lys Gln Gly Cys Trp Leu Asp Asp Ile 
    50                  55                  60                  


Asn Cys Tyr Asp Arg Thr Asp Cys Val Glu Lys Lys Asp Ser Pro Glu 
65                  70                  75                  80  


Val Tyr Phe Cys Cys Cys Glu Gly Asn Met Cys Asn Glu Lys Phe Ser 
                85                  90                  95      


Tyr Phe Pro Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
            100                 105                 110         


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Thr Leu Pro 
        115                 120                 125             


Phe Leu Lys Cys Tyr Cys Ser Gly His Cys Pro Asp Asp Ala Ile Asn 
    130                 135                 140                 


Asn Thr Cys Ile Thr Asn Gly His Cys Phe Ala Ile Ile Glu Glu Asp 
145                 150                 155                 160 


Asp Gln Gly Glu Thr Thr Leu Ala Ser Gly Cys Met Lys Tyr Glu Gly 
                165                 170                 175     


Ser Asp Phe Gln Cys Lys Asp Ser Pro Lys Ala Gln Leu Arg Arg Thr 
            180                 185                 190         


Ile Glu Cys Cys Arg Thr Asn Leu Cys Asn Gln Tyr Leu Gln Pro Thr 
        195                 200                 205             


Leu Pro Pro Val Val Ile Gly Pro Phe Phe Asp Gly Ser Ile Arg 
    210                 215                 220             


<210>  64
<211>  230
<212>  PRT
<213>  ActR-IIa/BMPR-Ia-v2b

<400>  64

Ala Ile Leu Gly Arg Ser Glu Thr Gln Glu Cys Leu Phe Phe Asn Ala 
1               5                   10                  15      


Asn Trp Glu Lys Asp Arg Thr Asn Gln Thr Gly Val Glu Pro Cys Tyr 
            20                  25                  30          


Gly Asp Lys Asp Lys Arg Arg His Cys Phe Ala Thr Trp Lys Asn Ile 
        35                  40                  45              


Ser Gly Ser Ile Glu Ile Val Lys Gln Gly Cys Trp Leu Asp Asp Ile 
    50                  55                  60                  


Asn Cys Tyr Asp Arg Thr Asp Cys Val Glu Lys Lys Asp Ser Pro Glu 
65                  70                  75                  80  


Val Tyr Phe Cys Cys Cys Glu Gly Asn Met Cys Asn Glu Lys Phe Ser 
                85                  90                  95      


Tyr Phe Pro Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Thr Leu Pro Phe Leu Lys Cys Tyr Cys Ser Gly His 
    130                 135                 140                 


Cys Pro Asp Asp Ala Ile Asn Asn Thr Cys Ile Thr Asn Gly His Cys 
145                 150                 155                 160 


Phe Ala Ile Ile Glu Glu Asp Asp Gln Gly Glu Thr Thr Leu Ala Ser 
                165                 170                 175     


Gly Cys Met Lys Tyr Glu Gly Ser Asp Phe Gln Cys Lys Asp Ser Pro 
            180                 185                 190         


Lys Ala Gln Leu Arg Arg Thr Ile Glu Cys Cys Arg Thr Asn Leu Cys 
        195                 200                 205             


Asn Gln Tyr Leu Gln Pro Thr Leu Pro Pro Val Val Ile Gly Pro Phe 
    210                 215                 220                 


Phe Asp Gly Ser Ile Arg 
225                 230 


<210>  65
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic linker


<220>
<221>  223
<222>  (1)..(25)
<223>  synthetic linker 1; corresponds to SEQ ID NO 82 as referred to in
       document WO 2008/113185 on page 46 line 8

<400>  65

Pro Phe Lys Val Ala Gly Asn Asn Asp Thr Val Ile Met Asp Asn Asn 
1               5                   10                  15      


Val Ser Lys Gln Val His Pro Pro Ile 
            20                  25  


<210>  66
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker

<400>  66

Asp Pro Asn Ser Thr Asn Tyr Glu Glu Ser 
1               5                   10  


<210>  67
<211>  50
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic linker

<400>  67

Pro Phe Lys Val Ala Gly Asn Asn Asp Thr Val Ile Met Asp Asn Asn 
1               5                   10                  15      


Ile His Arg Leu Pro His Ala Thr Arg Asn Cys Ser Pro Cys Ile Ile 
            20                  25                  30          


Glu Asp Lys Gln Ala Glu Met Glu Val Asp Ser Lys Gln Val His Pro 
        35                  40                  45              


Pro Ile 
    50  


<210>  68
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker

<400>  68

Thr Ala Gly Pro Leu Leu Ala Ala 
1               5               


<210>  69
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker

<400>  69

Glu Val Pro Gly Leu Gly Pro Ser Ser Lys Val Thr Thr Pro 
1               5                   10                  


<210>  70
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker

<400>  70

Glu Ser Arg Gly Leu Ile Ala 
1               5           


<210>  71
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker

<400>  71

Ile Asn Tyr Tyr Pro Pro Lys Pro Thr Val Pro Asn Ser Thr Pro Gln 
1               5                   10                  15      


Thr Val Glu Met Glu 
            20      


<210>  72
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker

<400>  72

Thr Glu Ala Glu Gly Arg Gly Ser 
1               5               


<210>  73
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker

<400>  73

Thr Pro Ala Thr Pro Pro Pro Glu Tyr Thr Val Glu Pro Gly Gly Ala 
1               5                   10                  15      


Glu 
    


<210>  74
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker

<400>  74

Asp Glu Pro Ala Leu Thr Val Gly Asn Glu Ser Lys Lys Gln Asp Ser 
1               5                   10                  15      


Asp Ser Lys Met Gly Thr Gly His Leu Met Ser Asp Leu Asn Gln 
            20                  25                  30      


<210>  75
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker


<220>
<221>  223
<222>  (1)..(13)
<223>  synthetic linker 38; corresponds to SEQ ID NO 92 as referred to 
       in document WO 2008/113185 in Table II on page 46 line 20

<400>  75

Arg Ile Ser Gly Asp Phe Phe Pro Gly Ile Val Val Pro 
1               5                   10              


<210>  76
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Linker

<400>  76

Phe Ile Ile Asn Asp Asn Cys Glu Asp Ser Ser Cys Ser Cys Met Phe 
1               5                   10                  15      


Phe Thr Glu Gly Pro Lys Lys Lys Glu Lys Met Ile Cys Lys Pro Ser 
            20                  25                  30          


Ala Ala Asp Glu Leu Ile Phe Asp His Tyr Pro Leu Lys Pro Asp His 
        35                  40                  45              


Cys Val Thr Glu Leu Thr Ile Asn Glu Asp Asn Lys Arg Trp Val Ala 
    50                  55                  60                  


Val Cys Val Glu Gln Pro Lys Glu Cys Ile Ser Thr Ile Ser Cys Asn 
65                  70                  75                  80  


Ser Met Cys Ser Lys Gln Asn Asp Cys Thr Ser Phe Arg Val Asp Cys 
                85                  90                  95      


Phe Lys Cys Leu Gln 
            100     


<210>  77
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Linker

<400>  77

Phe Ile Ile Asn Asp Asn Cys Glu Asp Ser Ser Cys Ser Cys Met Phe 
1               5                   10                  15      


Phe Thr Glu Gly Pro Lys Lys Lys Glu Lys Met Ile Cys Lys Pro Ser 
            20                  25                  30          


Ala Ala Asp Glu Leu Ile Phe Asp His Tyr Pro Leu Lys Pro Asp His 
        35                  40                  45              


Cys Val Thr Glu Leu Thr Ile Asn Glu Asp Asn Lys Arg Trp Val Ala 
    50                  55                  60                  


Val Cys Val Glu Gln Pro Lys Glu Cys Ile Ser Thr Ile Ser Cys Asn 
65                  70                  75                  80  


Ser Met Cys Ser Lys Gln Asn Asp Cys Thr Ser Phe Arg Val Asp Cys 
                85                  90                  95      


Phe Lys Cys Leu Gln 
            100     


<210>  78
<211>  79
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Linker

<400>  78

Leu Glu Ile Lys Asn Cys His Asp Gln Asn Cys Cys Tyr Thr Thr Thr 
1               5                   10                  15      


Val Ser Gly Thr Lys Ser Ser Pro Ala Cys Val Phe Pro Arg Asp Arg 
            20                  25                  30          


Pro Ile Leu Asp Ile Glu Ala Ile Cys Met Ser Asn His Ile Val Lys 
        35                  40                  45              


Asp Thr Thr Glu Thr Val Ser Val Phe Cys Leu Gly Asp Thr Val Cys 
    50                  55                  60                  


Thr Phe Asn Asp Lys Thr Cys Leu His Cys Phe Cys Gln Leu Ala 
65                  70                  75                  


<210>  79
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Linker

<400>  79

Pro Phe Tyr Ser Phe Lys Glu Asn Cys Met Asn Gly Glu Cys Cys Cys 
1               5                   10                  15      


Phe Tyr Val Glu Pro Ser Asp Lys Lys Glu Val Cys Asp Thr Arg Asp 
            20                  25                  30          


Tyr Cys Asn Ile Asp Asp Leu Trp Cys Gly Gln Lys Val Ile Glu Ile 
        35                  40                  45              


Ser Gly Ser Ile Asn Lys Trp Thr Ala Phe Cys His Arg Arg Lys Asp 
    50                  55                  60                  


Lys Asp Gly Tyr Cys Pro Glu Val Gly Thr Gln Asn Thr Arg Asp Lys 
65                  70                  75                  80  


Glu Trp Asn Ala Asn Phe Phe Leu Cys Glu Gln Thr 
                85                  90          


<210>  80
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Linker

<400>  80

Thr Pro Ala Thr Pro Pro Pro Glu Tyr Thr Val Glu Pro Gly Gly Ala 
1               5                   10                  15      


Glu Pro Leu His Thr Phe Arg Glu Asn Cys Phe Asn Gly Glu Cys Cys 
            20                  25                  30          


Cys Phe Tyr Val Gln Pro Asn Glu Glu Thr Ala Val Cys Glu Gln Arg 
        35                  40                  45              


Asp Tyr Cys Asn Phe Asp Asp Leu Trp Cys Gly Lys Lys Val Leu Glu 
    50                  55                  60                  


Ile Thr Gly Ser Ser Asn Arg Trp Ser Ala Tyr Cys His Leu Arg Lys 
65                  70                  75                  80  


Asp Gln Glu Gly Glu Cys Arg Glu Leu Gly Ser Gln Asn Thr Arg Glu 
                85                  90                  95      


Leu Glu Trp Asn Ala Asn Tyr Tyr Ile Cys Glu Arg 
            100                 105             


<210>  81
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Linker

<400>  81

Arg Ile Ser Gly Asp Phe Phe Pro Gly Ile Val Val Pro Pro Leu Thr 
1               5                   10                  15      


Pro Gln Leu Tyr Gln Asn Cys Leu Asn Thr Arg Cys Cys Glu Ile Thr 
            20                  25                  30          


Arg Arg Leu Gln Ala Lys Pro Ser Asp Lys Cys Gln Phe Asp Ser Gly 
        35                  40                  45              


Glu Tyr Lys Met Cys Gly Ser Ala Leu Thr Thr Glu Gly Gln Asp Asp 
    50                  55                  60                  


Glu Glu Ile Ile Ala Phe Cys His Gly Asn Thr Ile Cys Thr Asn Asn 
65                  70                  75                  80  


Ile Ala Asp Asp Pro Cys His Gly Ser Cys Tyr Cys Lys Leu Phe Pro 
                85                  90                  95      


Leu Thr 
        


<210>  82
<211>  35
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker

<400>  82

Pro Phe Lys Val Ala Gly Asn Asn Asp Thr Val Ile Met Asp Asn Asn 
1               5                   10                  15      


Val Ser Lys Gln Val His Pro Pro Ile Asp Pro Asn Ser Thr Asn Tyr 
            20                  25                  30          


Glu Glu Ser 
        35  


<210>  83
<211>  60
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker

<400>  83

Pro Phe Lys Val Ala Gly Asn Asn Asp Thr Val Ile Met Asp Asn Asn 
1               5                   10                  15      


Ile His Arg Leu Pro His Ala Thr Arg Asn Cys Ser Pro Cys Ile Ile 
            20                  25                  30          


Glu Asp Lys Gln Ala Glu Met Glu Val Asp Ser Lys Gln Val His Pro 
        35                  40                  45              


Pro Ile Asp Pro Asn Ser Thr Asn Tyr Glu Glu Ser 
    50                  55                  60  


<210>  84
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker

<400>  84

Thr Glu Ala Glu Gly Arg Gly Ser Thr Pro Ala Thr Pro Pro Pro Glu 
1               5                   10                  15      


Tyr Thr Val Glu Pro Gly Gly Ala Glu 
            20                  25  


<210>  85
<211>  44
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker

<400>  85

Asp Glu Pro Ala Leu Thr Val Gly Asn Glu Ser Lys Lys Gln Asp Ser 
1               5                   10                  15      


Asp Ser Lys Met Gly Thr Gly His Leu Met Ser Asp Leu Asn Gln Arg 
            20                  25                  30          


Ile Ser Gly Asp Phe Phe Pro Gly Ile Val Val Pro 
        35                  40                  


<210>  86
<211>  44
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker

<400>  86

Asp Glu Pro Ala Leu Thr Val Gly Asn Glu Ser Lys Lys Gln Asp Ser 
1               5                   10                  15      


Asp Ser Lys Met Gly Thr Gly His Leu Met Ser Asp Leu Asn Gly Arg 
            20                  25                  30          


Ile Ser Gly Asp Phe Phe Pro Gly Ile Val Val Pro 
        35                  40                  


<210>  87
<211>  35
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker

<400>  87

Pro Phe Lys Val Ala Gly Asn Asn Asp Thr Val Ile Met Asp Asn Asn 
1               5                   10                  15      


Val Ser Lys Gln Val His Pro Pro Gly Asp Pro Asn Ser Thr Asn Tyr 
            20                  25                  30          


Glu Glu Ser 
        35  


<210>  88
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker

<400>  88

Thr Glu Ala Glu Gly Arg Gly Ser Thr Pro Ala Thr Pro Pro Pro Glu 
1               5                   10                  15      


Gly Thr Val Glu Pro Gly Gly Ala Glu 
            20                  25  


<210>  89
<211>  60
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker

<400>  89

Pro Phe Lys Val Ala Gly Asn Asn Asp Thr Val Ile Met Asp Asn Asn 
1               5                   10                  15      


Ile His Arg Leu Pro His Ala Thr Arg Asn Cys Ser Pro Cys Ile Ile 
            20                  25                  30          


Glu Asp Lys Gln Ala Glu Met Glu Val Asp Ser Lys Gln Val His Arg 
        35                  40                  45              


Gly Gly Asp Pro Asn Ser Thr Asn Tyr Glu Glu Ser 
    50                  55                  60  


<210>  90
<211>  35
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker

<400>  90

Pro Phe Lys Val Ala Gly Asn Asn Asp Thr Val Ile Met Asp Asn Asn 
1               5                   10                  15      


Val Ser Lys Gln Val His Pro Gly Gly Asp Pro Asn Ser Thr Asn Tyr 
            20                  25                  30          


Glu Glu Ser 
        35  


<210>  91
<211>  35
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker

<400>  91

Pro Phe Lys Val Ala Gly Asn Asn Asp Thr Val Ile Met Asp Asn Asn 
1               5                   10                  15      


Val Ser Lys Gln Val His Arg Gly Gly Asp Pro Asn Ser Thr Asn Tyr 
            20                  25                  30          


Glu Glu Ser 
        35  


<210>  92
<211>  60
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker

<400>  92

Pro Phe Lys Val Ala Gly Asn Asn Asp Thr Val Ile Met Asp Asn Asn 
1               5                   10                  15      


Ile His Arg Leu Pro His Ala Thr Arg Asn Cys Ser Pro Cys Ile Ile 
            20                  25                  30          


Glu Asp Lys Gln Ala Glu Met Gly Gly Gly Ser Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Ser Pro Asn Ser Thr Asn Tyr Glu Glu Ser 
    50                  55                  60  


<210>  93
<211>  35
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker

<400>  93

Pro Phe Lys Val Ala Gly Asn Asn Asp Thr Val Ile Met Asp Asn Asn 
1               5                   10                  15      


Val Ser Lys Gly Gly Ser Gly Gly Gly Ser Pro Asn Ser Thr Asn Tyr 
            20                  25                  30          


Glu Glu Ser 
        35  


<210>  94
<211>  35
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker

<400>  94

Pro Phe Lys Val Ala Gly Asn Asn Asp Thr Val Ile Met Asp Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Pro Asn Ser Thr Asn Tyr 
            20                  25                  30          


Glu Glu Ser 
        35  


<210>  95
<211>  60
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker

<400>  95

Pro Phe Lys Val Ala Gly Asn Asn Asp Thr Val Ile Met Asp Asn Asn 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Lys Gln Val His Pro 
        35                  40                  45              


Pro Ile Asp Pro Asn Ser Thr Asn Tyr Glu Glu Ser 
    50                  55                  60  


<210>  96
<211>  60
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker

<400>  96

Pro Phe Lys Val Ala Gly Asn Asn Asp Thr Val Ile Met Asp Asn Asn 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Gly Asp Pro Asn Ser Thr Asn Tyr Glu Glu Ser 
    50                  55                  60  


<210>  97
<211>  35
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker

<400>  97

Pro Phe Lys Val Ala Gly Asn Asn Asp Thr Val Ile Met Asp Asn Asn 
1               5                   10                  15      


Val Ser Lys Gln Val His Pro Pro Ile Asp Pro Asn Ser Thr Asn Tyr 
            20                  25                  30          


Glu Glu Ser 
        35  


<210>  98
<211>  48
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker

<400>  98

Pro Phe Lys Val Ala Gly Asn Asn Asp Thr Val Ile Met Asp Asn Asn 
1               5                   10                  15      


Val Ser Lys Gln Val His Pro Pro Ile Met Asp Asn Asn Val Ser Lys 
            20                  25                  30          


Gln Val His Pro Pro Ile Asp Pro Asn Ser Thr Asn Tyr Glu Glu Ser 
        35                  40                  45              


<210>  99
<211>  32
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker

<400>  99

Pro Phe Lys Val Ala Gly Asn Asn Asp Thr Val Ile Met Asp Asn Asn 
1               5                   10                  15      


Val Ser Lys Gln Val His Pro Pro Asn Ser Thr Asn Tyr Glu Glu Ser 
            20                  25                  30          


<210>  100
<211>  43
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker

<400>  100

Pro Phe Lys Val Ala Gly Asn Asn Asp Thr Val Ile Met Asp Asn Asn 
1               5                   10                  15      


Val Ser Lys Gln Val His Pro Pro Ile Gly Gly Gly Gly Gly Gly Gly 
            20                  25                  30          


Gly Asp Pro Asn Ser Thr Asn Tyr Glu Glu Ser 
        35                  40              


<210>  101
<211>  47
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker

<400>  101

Pro Phe Lys Val Ala Gly Asn Asn Asp Thr Val Ile Met Asp Asn Asn 
1               5                   10                  15      


Val Ser Lys Gln Val His Pro Pro Ile Ser Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Ser Gly Gly Gly Asp Pro Asn Ser Thr Asn Tyr Glu Glu Ser 
        35                  40                  45          


<210>  102
<211>  60
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker

<400>  102

Pro Phe Lys Val Ala Gly Asn Asn Asp Thr Val Ile Met Asp Asn Asn 
1               5                   10                  15      


Ile His Arg Leu Pro His Ala Thr Arg Asn Cys Ser Pro Cys Ile Ile 
            20                  25                  30          


Glu Asp Lys Gln Ala Glu Met Glu Val Asp Ser Lys Gln Val His Pro 
        35                  40                  45              


Pro Ile Asp Pro Asn Ser Thr Asn Tyr Glu Glu Ser 
    50                  55                  60  


<210>  103
<211>  53
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker

<400>  103

Pro Phe Lys Val Ala Gly Asn Asn Asp Thr Val Ile Met Asp Asn Asn 
1               5                   10                  15      


Ile His Arg Leu Pro His Ala Thr Arg Glu Asp Lys Gln Ala Glu Met 
            20                  25                  30          


Glu Val Asp Ser Lys Gln Val His Pro Pro Ile Asp Pro Asn Ser Thr 
        35                  40                  45              


Asn Tyr Glu Glu Ser 
    50              


<210>  104
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker

<400>  104

Thr Glu Ala Glu Gly Arg Gly Ser Thr Pro Ala Thr Pro Pro Pro Glu 
1               5                   10                  15      


Tyr Thr Val Glu Pro Gly Gly Ala Glu 
            20                  25  


<210>  105
<211>  35
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker

<400>  105

Thr Glu Ala Glu Gly Arg Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Thr Pro Ala Thr Pro Pro Pro Glu Tyr Thr Val Glu Pro Gly 
            20                  25                  30          


Gly Ala Glu 
        35  


<210>  106
<211>  44
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker

<400>  106

Asp Glu Pro Ala Leu Thr Val Gly Asn Glu Ser Lys Lys Gln Asp Ser 
1               5                   10                  15      


Asp Ser Lys Met Gly Thr Gly His Leu Met Ser Asp Leu Asn Gln Arg 
            20                  25                  30          


Ile Ser Gly Asp Phe Phe Pro Gly Ile Val Val Pro 
        35                  40                  


<210>  107
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic linker

<400>  107

Asp Glu Pro Ala Leu Thr Val Gly Asn Glu Ser Lys Lys Gln Asp Ser 
1               5                   10                  15      


Asp Ser Lys Met Gly Thr Gly His Ser Asp Leu Asn Gln Arg Ile Ser 
            20                  25                  30          


Gly Asp Pro Gly Ile Val Val Pro 
        35                  40  


<210>  108
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Linker

<400>  108

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His His His His His His His Gly Gly Ser Phe 
        35                  40                  45              


Asn Pro Arg 
    50      


