                         SEQUENCE LISTING

<110>  Mount Sinai School of Medicine of New York University
 
<120>  NOVEL AUTOPHAGY REGULATORS ATG14L AND RUBICON

<130>  070165.0655

<140>  PCT/US09/56728
<141>  2009-09-11

<150>  US 61/096,724
<151>  2008-09-12

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  492
<212>  PRT
<213>  Mus musculus


<220>
<221>  Amino acid sequence of murine ATG14L protein
<222>  (1)..(492)

<400>  1

Met Ala Ser Pro Ser Gly Lys Gly Ser Trp Thr Pro Glu Ala Pro Gly 
1               5                   10                  15      


Phe Gly Pro Arg Ala Leu Ala Arg Asp Leu Val Asp Ser Val Asp Asp 
            20                  25                  30          


Ala Glu Gly Leu Tyr Val Ala Val Glu Arg Cys Pro Leu Cys Asn Thr 
        35                  40                  45              


Thr Arg Arg Arg Leu Thr Cys Ala Lys Cys Val Gln Ser Gly Asp Phe 
    50                  55                  60                  


Val Tyr Phe Asp Gly Arg Asp Arg Glu Arg Phe Ile Asp Lys Lys Glu 
65                  70                  75                  80  


Arg Leu Ser Gln Leu Lys Asn Lys Gln Glu Glu Phe Gln Lys Glu Val 
                85                  90                  95      


Leu Lys Ala Met Glu Gly Lys Arg Leu Thr Asp Gln Leu Arg Trp Lys 
            100                 105                 110         


Ile Met Ser Cys Lys Met Arg Ile Glu Gln Leu Lys Gln Thr Ile Cys 
        115                 120                 125             


Lys Gly Asn Glu Glu Met Lys Lys Asn Ser Glu Gly Leu Leu Lys Asn 
    130                 135                 140                 


Lys Glu Lys Asn Gln Lys Leu Tyr Ser Arg Ala Gln Arg His Gln Glu 
145                 150                 155                 160 


Lys Lys Glu Lys Ile Gln Arg His Asn Arg Lys Leu Gly Asp Leu Val 
                165                 170                 175     


Glu Lys Lys Thr Ile Asp Leu Lys Ser His Tyr Glu Arg Leu Ala Arg 
            180                 185                 190         


Leu Arg Arg Ser His Ile Leu Glu Leu Thr Ser Ile Ile Phe Pro Ile 
        195                 200                 205             


Asp Glu Val Lys Thr Ser Gly Arg Asp Pro Ala Asp Val Ser Ser Glu 
    210                 215                 220                 


Thr Asp Ser Ala Met Thr Ser Ser Met Val Ser Lys Leu Ala Glu Ala 
225                 230                 235                 240 


Arg Arg Thr Thr Tyr Leu Ser Gly Arg Trp Val Cys Asp Asp His Asn 
                245                 250                 255     


Gly Asp Thr Ser Ile Ser Ile Thr Gly Pro Trp Ile Ser Leu Pro Asn 
            260                 265                 270         


Asn Gly Asp Tyr Ser Ala Tyr Tyr Asn Trp Val Glu Glu Lys Lys Thr 
        275                 280                 285             


Thr Gln Gly Pro Asp Met Glu His Asn Asn Pro Ala Tyr Thr Ile Ser 
    290                 295                 300                 


Ala Ala Leu Gly Tyr Ala Thr Gln Leu Val Asn Ile Val Ser His Ile 
305                 310                 315                 320 


Leu Asp Ile Asn Leu Pro Lys Lys Leu Cys Asn Ser Glu Phe Cys Gly 
                325                 330                 335     


Glu Asn Leu Ser Lys Gln Lys Leu Thr Arg Ala Val Arg Lys Leu Asn 
            340                 345                 350         


Ala Asn Ile Leu Tyr Leu Cys Ser Ser Gln His Val Asn Leu Asp Gln 
        355                 360                 365             


Leu Gln Pro Leu His Thr Leu Arg Asn Leu Met His Leu Val Ser Pro 
    370                 375                 380                 


Arg Ser Glu His Leu Gly Arg Ser Gly Pro Phe Glu Val Arg Ala Asp 
385                 390                 395                 400 


Leu Glu Glu Ser Met Glu Phe Val Asp Pro Gly Val Ala Gly Glu Ser 
                405                 410                 415     


Asp Ala Ser Gly Asp Glu Arg Val Ser Asp Glu Glu Thr Asp Leu Gly 
            420                 425                 430         


Thr Asp Trp Glu Asn Leu Pro Ser Pro Arg Phe Cys Asp Ile Pro Ser 
        435                 440                 445             


Gln Pro Val Glu Val Ser Gln Ser Gln Ser Thr Gln Val Ser Pro Pro 
    450                 455                 460                 


Ile Ala Ser Ser Ser Ala Gly Gly Met Ile Ser Ser Ala Ala Ala Ser 
465                 470                 475                 480 


Val Thr Ser Trp Phe Lys Ala Tyr Thr Gly His Arg 
                485                 490         


<210>  2
<211>  941
<212>  PRT
<213>  Mus musculus


<220>
<221>  Amino acid sequence of murine Rubicon protein
<222>  (1)..(941)

<400>  2

Met Arg Pro Glu Gly Ala Gly Met Asp Leu Gly Gly Gly Asp Gly Glu 
1               5                   10                  15      


Arg Leu Leu Glu Lys Ser Arg Arg Glu His Trp Gln Leu Leu Gly Asn 
            20                  25                  30          


Leu Lys Thr Thr Val Glu Gly Leu Val Ser Ala Asn Cys Pro Asn Val 
        35                  40                  45              


Trp Ser Lys Tyr Gly Gly Leu Glu Arg Leu Cys Arg Asp Met Gln Asn 
    50                  55                  60                  


Ile Leu Tyr His Gly Leu Ile His Asp Gln Val Cys Cys Arg Gln Ala 
65                  70                  75                  80  


Asp Tyr Trp Gln Phe Val Lys Asp Ile Arg Trp Leu Ser Pro His Ser 
                85                  90                  95      


Ala Leu His Val Glu Lys Phe Ile Ser Leu His Glu Ser Asp Gln Ser 
            100                 105                 110         


Asp Thr Asp Ser Val Ser Glu Arg Ala Val Ala Glu Leu Trp Leu Gln 
        115                 120                 125             


His Ser Leu Gln Cys His Cys Leu Ser Ala Gln Leu Arg Pro Leu Leu 
    130                 135                 140                 


Gly Asp Arg Gln Tyr Ile Arg Lys Phe Tyr Thr Glu Thr Ala Phe Leu 
145                 150                 155                 160 


Leu Ser Asp Ala His Val Thr Ala Met Leu Gln Cys Leu Glu Ala Val 
                165                 170                 175     


Glu Gln Asn Asn Pro Arg Leu Leu Ala Gln Ile Asp Ala Ser Met Phe 
            180                 185                 190         


Ala Arg Lys Gln Glu Ser Pro Leu Leu Val Thr Lys Ser Gln Ser Leu 
        195                 200                 205             


Thr Ala Leu Pro Gly Ser Thr Tyr Thr Pro Pro Ala Ser Tyr Ala Gln 
    210                 215                 220                 


His Ser Tyr Phe Gly Ser Ser Ser Ser Leu Gln Ser Met Pro Gln Ser 
225                 230                 235                 240 


Ser His Ser Ser Glu Arg Arg Ser Thr Ser Phe Ser Leu Ser Gly Pro 
                245                 250                 255     


Ser Trp Gln Pro Gln Glu Asp Arg Glu Cys Leu Ser Pro Ala Glu Thr 
            260                 265                 270         


Gln Thr Thr Pro Ala Pro Leu Pro Ser Asp Ser Thr Leu Ala Gln Asp 
        275                 280                 285             


Ser Pro Leu Thr Ala Gln Glu Met Ser Asp Ser Thr Leu Thr Ser Pro 
    290                 295                 300                 


Leu Glu Ala Ser Trp Val Ser Ser Gln Asn Asp Ser Pro Ser Asp Val 
305                 310                 315                 320 


Ser Glu Gly Pro Glu Tyr Leu Ala Ile Gly Asn Pro Ala Pro His Gly 
                325                 330                 335     


Arg Thr Ala Ser Cys Glu Ser His Ser Ser Asn Gly Glu Ser Ser Ser 
            340                 345                 350         


Ser His Leu Phe Ser Ser Ser Ser Ser Gln Lys Leu Glu Ser Ala Ala 
        355                 360                 365             


Ser Ser Leu Gly Asp Gln Glu Glu Gly Arg Gln Ser Gln Ala Gly Ser 
    370                 375                 380                 


Val Leu Arg Arg Ser Ser Phe Ser Glu Gly Gln Thr Ala Pro Val Ala 
385                 390                 395                 400 


Ser Gly Thr Lys Lys Ser His Ile Arg Ser His Ser Asp Thr Asn Ile 
                405                 410                 415     


Ala Ser Arg Gly Ala Ala Glu Gly Gly Gln Tyr Leu Cys Ser Gly Glu 
            420                 425                 430         


Gly Met Phe Arg Arg Pro Ser Glu Gly Gln Ser Leu Ile Ser Tyr Leu 
        435                 440                 445             


Ser Glu Gln Asp Phe Gly Ser Cys Ala Asp Leu Glu Lys Glu Asn Ala 
    450                 455                 460                 


His Phe Ser Ile Ser Glu Ser Leu Ile Ala Ala Ile Glu Leu Met Lys 
465                 470                 475                 480 


Cys Asn Met Met Ser Gln Cys Leu Glu Glu Glu Glu Val Glu Glu Glu 
                485                 490                 495     


Asp Ser Asp Arg Glu Ile Gln Glu Leu Lys Gln Lys Ile Arg Leu Arg 
            500                 505                 510         


Arg Gln Gln Ile Arg Thr Lys Asn Leu Leu Pro Ala Tyr Arg Glu Thr 
        515                 520                 525             


Glu Asn Gly Ser Phe Arg Val Thr Ser Ser Ser Ser Gln Phe Ser Ser 
    530                 535                 540                 


Arg Asp Ser Thr Gln Leu Ser Glu Ser Gly Ser Ala Glu Asp Ala Asp 
545                 550                 555                 560 


Asp Leu Glu Ile Gln Asp Ala Asp Ile Arg Arg Ser Ala Val Ser Asn 
                565                 570                 575     


Gly Lys Ser Ser Phe Ser Gln Asn Leu Ser His Cys Phe Leu His Ser 
            580                 585                 590         


Thr Ser Ala Glu Ala Val Ala Met Gly Leu Leu Lys Gln Phe Glu Gly 
        595                 600                 605             


Met Gln Leu Pro Ala Ala Ser Glu Leu Glu Trp Leu Val Pro Glu His 
    610                 615                 620                 


Asp Ala Pro Gln Lys Leu Leu Pro Ile Pro Asp Ser Leu Pro Ile Ser 
625                 630                 635                 640 


Pro Asp Asp Gly Gln His Ala Asp Ile Tyr Lys Leu Arg Ile Arg Val 
                645                 650                 655     


Arg Gly Asn Leu Glu Trp Ala Pro Pro Arg Pro Gln Ile Ile Phe Asn 
            660                 665                 670         


Val His Pro Ala Pro Thr Arg Lys Ile Ala Val Ala Lys Gln Asn Tyr 
        675                 680                 685             


Arg Cys Ala Gly Cys Gly Ile Arg Thr Asp Pro Asp Tyr Ile Lys Arg 
    690                 695                 700                 


Leu Arg Tyr Cys Glu Tyr Leu Gly Lys Tyr Phe Cys Gln Cys Cys His 
705                 710                 715                 720 


Glu Asn Ala Gln Met Val Val Pro Ser Arg Ile Leu Arg Lys Trp Asp 
                725                 730                 735     


Phe Ser Lys Tyr Tyr Val Ser Asn Phe Ser Lys Asp Leu Leu Leu Lys 
            740                 745                 750         


Ile Trp Asn Asp Pro Leu Phe Asn Val Gln Asp Ile Asn Ser Ala Leu 
        755                 760                 765             


Tyr Arg Lys Val Lys Leu Leu Asn Gln Val Arg Leu Leu Arg Val Gln 
    770                 775                 780                 


Leu Tyr His Met Lys Asn Met Phe Lys Thr Cys Arg Leu Ala Lys Glu 
785                 790                 795                 800 


Leu Leu Asp Ser Phe Asp Val Val Pro Gly His Leu Thr Glu Asp Leu 
                805                 810                 815     


His Leu Tyr Ser Leu Ser Asp Leu Thr Ala Thr Lys Lys Gly Glu Leu 
            820                 825                 830         


Gly Pro Arg Leu Ala Glu Leu Thr Arg Ala Gly Ala Ala His Val Glu 
        835                 840                 845             


Arg Cys Met Leu Cys Gln Ala Lys Gly Phe Ile Cys Glu Phe Cys Gln 
    850                 855                 860                 


Asn Glu Glu Asp Val Ile Phe Pro Phe Glu Leu His Lys Cys Arg Thr 
865                 870                 875                 880 


Cys Glu Glu Cys Lys Ala Cys Tyr His Lys Thr Cys Phe Lys Ser Gly 
                885                 890                 895     


Arg Cys Pro Arg Cys Glu Arg Leu Gln Ala Arg Arg Glu Leu Leu Ala 
            900                 905                 910         


Lys Gln Ser Leu Glu Ser Tyr Leu Ser Asp Tyr Glu Glu Glu Pro Thr 
        915                 920                 925             


Glu Ala Leu Ala Leu Glu Ala Thr Val Leu Glu Thr Thr 
    930                 935                 940     


<210>  3
<211>  492
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Amino acid sequence of human ATG14L protein
<222>  (1)..(492)

<400>  3

Met Ala Ser Pro Ser Gly Lys Gly Ala Arg Ala Leu Glu Ala Pro Gly 
1               5                   10                  15      


Cys Gly Pro Arg Pro Leu Ala Arg Asp Leu Val Asp Ser Val Asp Asp 
            20                  25                  30          


Ala Glu Gly Leu Tyr Val Ala Val Glu Arg Cys Pro Leu Cys Asn Thr 
        35                  40                  45              


Thr Arg Arg Arg Leu Thr Cys Ala Lys Cys Val Gln Ser Gly Asp Phe 
    50                  55                  60                  


Val Tyr Phe Asp Gly Arg Asp Arg Glu Arg Phe Ile Asp Lys Lys Glu 
65                  70                  75                  80  


Arg Leu Ser Arg Leu Lys Ser Lys Gln Glu Glu Phe Gln Lys Glu Val 
                85                  90                  95      


Leu Lys Ala Met Glu Gly Lys Trp Ile Thr Asp Gln Leu Arg Trp Lys 
            100                 105                 110         


Ile Met Ser Cys Lys Met Arg Ile Glu Gln Leu Lys Gln Thr Ile Cys 
        115                 120                 125             


Lys Gly Asn Glu Glu Met Glu Lys Asn Ser Glu Gly Leu Leu Lys Thr 
    130                 135                 140                 


Lys Glu Lys Asn Gln Lys Leu Tyr Ser Arg Ala Gln Arg His Gln Glu 
145                 150                 155                 160 


Lys Lys Glu Lys Ile Gln Arg His Asn Arg Lys Leu Gly Asp Leu Val 
                165                 170                 175     


Glu Lys Lys Thr Ile Asp Leu Arg Ser His Tyr Glu Arg Leu Ala Asn 
            180                 185                 190         


Leu Arg Arg Ser His Ile Leu Glu Leu Thr Ser Val Ile Phe Pro Ile 
        195                 200                 205             


Glu Glu Val Lys Thr Gly Val Arg Asp Pro Ala Asp Val Ser Ser Glu 
    210                 215                 220                 


Ser Asp Ser Ala Met Thr Ser Ser Thr Val Ser Lys Leu Ala Glu Ala 
225                 230                 235                 240 


Arg Arg Thr Thr Tyr Leu Ser Gly Arg Trp Val Cys Asp Asp His Asn 
                245                 250                 255     


Gly Asp Thr Ser Ile Ser Ile Thr Gly Pro Trp Ile Ser Leu Pro Asn 
            260                 265                 270         


Asn Gly Asp Tyr Ser Ala Tyr Tyr Ser Trp Val Glu Glu Lys Lys Thr 
        275                 280                 285             


Thr Gln Gly Pro Asp Met Glu Gln Ser Asn Pro Ala Tyr Thr Ile Ser 
    290                 295                 300                 


Ala Ala Leu Cys Tyr Ala Thr Gln Leu Val Asn Ile Leu Ser His Ile 
305                 310                 315                 320 


Leu Asp Val Asn Leu Pro Lys Lys Leu Cys Asn Ser Glu Phe Cys Gly 
                325                 330                 335     


Glu Asn Leu Ser Lys Gln Lys Phe Thr Arg Ala Val Lys Lys Leu Asn 
            340                 345                 350         


Ala Asn Ile Leu Tyr Leu Cys Phe Ser Gln His Val Asn Leu Asp Gln 
        355                 360                 365             


Leu Gln Pro Leu His Thr Leu Arg Asn Leu Met Tyr Leu Val Ser Pro 
    370                 375                 380                 


Ser Ser Glu His Leu Gly Arg Ser Gly Pro Phe Glu Val Arg Ala Asp 
385                 390                 395                 400 


Leu Glu Glu Ser Met Glu Phe Val Asp Pro Gly Val Ala Gly Glu Ser 
                405                 410                 415     


Asp Glu Ser Gly Asp Glu Arg Val Ser Asp Glu Glu Thr Asp Leu Gly 
            420                 425                 430         


Thr Asp Trp Glu Asn Leu Pro Ser Pro Arg Phe Cys Asp Ile Pro Ser 
        435                 440                 445             


Gln Ser Val Glu Val Ser Gln Ser Gln Ser Thr Gln Ala Ser Pro Pro 
    450                 455                 460                 


Ile Ala Ser Ser Ser Ala Gly Gly Met Ile Ser Ser Ala Ala Ala Ser 
465                 470                 475                 480 


Val Thr Ser Trp Phe Lys Ala Tyr Thr Gly His Arg 
                485                 490         


<210>  4
<211>  972
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Amino acid sequence of human Rubicon protein
<222>  (1)..(972)

<400>  4

Met Arg Pro Glu Gly Ala Gly Met Glu Leu Gly Gly Gly Glu Glu Arg 
1               5                   10                  15      


Leu Pro Glu Glu Ser Arg Arg Glu His Trp Gln Leu Leu Gly Asn Leu 
            20                  25                  30          


Lys Thr Thr Val Glu Gly Leu Val Ser Thr Asn Ser Pro Asn Val Trp 
        35                  40                  45              


Ser Lys Tyr Gly Gly Leu Glu Arg Leu Cys Arg Asp Met Gln Ser Ile 
    50                  55                  60                  


Leu Tyr His Gly Leu Ile Arg Asp Gln Ala Cys Arg Arg Gln Thr Asp 
65                  70                  75                  80  


Tyr Trp Gln Phe Val Lys Asp Ile Arg Trp Leu Ser Pro His Ser Ala 
                85                  90                  95      


Leu His Val Glu Lys Phe Ile Ser Val His Glu Asn Asp Gln Ser Ser 
            100                 105                 110         


Ala Asp Gly Ala Ser Glu Arg Ala Val Ala Glu Leu Trp Leu Gln His 
        115                 120                 125             


Ser Leu Gln Tyr His Cys Leu Ser Ala Gln Leu Arg Pro Leu Leu Gly 
    130                 135                 140                 


Asp Arg Gln Tyr Ile Arg Lys Phe Tyr Thr Asp Ala Ala Phe Leu Leu 
145                 150                 155                 160 


Ser Asp Ala His Val Thr Ala Met Leu Gln Cys Leu Glu Ala Val Glu 
                165                 170                 175     


Gln Asn Asn Pro Arg Leu Leu Ala Gln Ile Asp Ala Ser Met Phe Ala 
            180                 185                 190         


Arg Lys His Glu Ser Pro Leu Leu Val Thr Lys Ser Gln Ser Leu Thr 
        195                 200                 205             


Ala Leu Pro Ser Ser Thr Tyr Thr Pro Pro Asn Ser Tyr Ala Gln His 
    210                 215                 220                 


Ser Tyr Phe Gly Ser Phe Ser Ser Leu His Gln Ser Val Pro Asn Asn 
225                 230                 235                 240 


Gly Ser Glu Arg Arg Ser Thr Ser Phe Pro Leu Ser Gly Pro Pro Arg 
                245                 250                 255     


Lys Pro Gln Glu Ser Arg Gly His Val Ser Pro Ala Glu Asp Gln Thr 
            260                 265                 270         


Ile Gln Ala Pro Pro Val Ser Val Ser Ala Leu Ala Arg Asp Ser Pro 
        275                 280                 285             


Leu Thr Pro Asn Glu Met Ser Ser Ser Thr Leu Thr Ser Pro Ile Glu 
    290                 295                 300                 


Ala Ser Trp Val Ser Ser Gln Asn Asp Ser Pro Gly Asp Ala Ser Glu 
305                 310                 315                 320 


Gly Pro Glu Tyr Leu Ala Ile Gly Asn Leu Asp Pro Arg Gly Arg Thr 
                325                 330                 335     


Ala Ser Cys Gln Ser His Ser Ser Asn Ala Glu Ser Ser Ser Ser Asn 
            340                 345                 350         


Leu Phe Ser Ser Ser Ser Ser Gln Lys Pro Asp Ser Ala Ala Ser Ser 
        355                 360                 365             


Leu Gly Asp Gln Glu Gly Gly Gly Glu Ser Gln Leu Ser Ser Val Leu 
    370                 375                 380                 


Arg Arg Ser Ser Phe Ser Glu Gly Gln Thr Leu Thr Val Thr Ser Gly 
385                 390                 395                 400 


Ala Lys Lys Ser His Ile Arg Ser His Ser Asp Thr Ser Ile Ala Ser 
                405                 410                 415     


Arg Gly Ala Pro Glu Ser Cys Asn Asp Lys Ala Lys Leu Arg Gly Pro 
            420                 425                 430         


Leu Pro Tyr Ser Gly Gln Ser Ser Glu Val Ser Thr Pro Ser Ser Leu 
        435                 440                 445             


Tyr Met Glu Tyr Glu Gly Gly Arg Tyr Leu Cys Ser Gly Glu Gly Met 
    450                 455                 460                 


Phe Arg Arg Pro Ser Glu Gly Gln Ser Leu Ile Ser Tyr Leu Ser Glu 
465                 470                 475                 480 


Gln Asp Phe Gly Ser Cys Ala Asp Leu Glu Lys Glu Asn Ala His Phe 
                485                 490                 495     


Ser Ile Ser Glu Ser Leu Ile Ala Ala Ile Glu Leu Met Lys Cys Asn 
            500                 505                 510         


Met Met Ser Gln Cys Leu Glu Glu Glu Glu Val Glu Glu Glu Asp Ser 
        515                 520                 525             


Asp Arg Glu Ile Gln Glu Leu Lys Gln Lys Ile Arg Leu Arg Arg Gln 
    530                 535                 540                 


Gln Ile Arg Thr Lys Asn Leu Leu Pro Met Tyr Gln Glu Ala Glu His 
545                 550                 555                 560 


Gly Ser Phe Arg Val Thr Ser Ser Ser Ser Gln Phe Ser Ser Arg Asp 
                565                 570                 575     


Ser Ala Gln Leu Ser Asp Ser Gly Ser Ala Asp Glu Val Asp Glu Phe 
            580                 585                 590         


Glu Ile Gln Asp Ala Asp Ile Arg Arg Asn Thr Ala Ser Ser Ser Lys 
        595                 600                 605             


Ser Phe Val Ser Ser Gln Ser Phe Ser His Cys Phe Leu His Ser Thr 
    610                 615                 620                 


Ser Ala Glu Ala Val Ala Met Gly Leu Leu Lys Gln Phe Glu Gly Met 
625                 630                 635                 640 


Gln Leu Pro Ala Ala Ser Glu Leu Glu Trp Leu Val Pro Glu His Asp 
                645                 650                 655     


Ala Pro Gln Lys Leu Leu Pro Ile Pro Asp Ser Leu Pro Ile Ser Pro 
            660                 665                 670         


Asp Asp Gly Gln His Ala Asp Ile Tyr Lys Leu Arg Ile Arg Val Arg 
        675                 680                 685             


Gly Asn Leu Glu Trp Ala Pro Pro Arg Pro Gln Ile Ile Phe Asn Val 
    690                 695                 700                 


His Pro Ala Pro Thr Arg Lys Ile Ala Val Ala Lys Gln Asn Tyr Arg 
705                 710                 715                 720 


Cys Ala Gly Cys Gly Ile Arg Thr Asp Pro Asp Tyr Ile Lys Arg Leu 
                725                 730                 735     


Arg Tyr Cys Glu Tyr Leu Gly Lys Tyr Phe Cys Gln Cys Cys His Glu 
            740                 745                 750         


Asn Ala Gln Met Ala Ile Pro Ser Arg Val Leu Arg Lys Trp Asp Phe 
        755                 760                 765             


Ser Lys Tyr Tyr Val Ser Asn Phe Ser Lys Asp Leu Leu Ile Lys Ile 
    770                 775                 780                 


Trp Asn Asp Pro Leu Phe Asn Val Gln Asp Ile Asn Ser Ala Leu Tyr 
785                 790                 795                 800 


Arg Lys Val Lys Leu Leu Asn Gln Val Arg Leu Leu Arg Val Gln Leu 
                805                 810                 815     


Cys His Met Lys Asn Met Phe Lys Thr Cys Arg Leu Ala Lys Glu Leu 
            820                 825                 830         


Leu Asp Ser Phe Asp Thr Val Pro Gly His Leu Thr Glu Asp Leu His 
        835                 840                 845             


Leu Tyr Ser Leu Asn Asp Leu Thr Ala Thr Arg Lys Gly Glu Leu Gly 
    850                 855                 860                 


Pro Arg Leu Ala Glu Leu Thr Arg Ala Gly Ala Thr His Val Glu Arg 
865                 870                 875                 880 


Cys Met Leu Cys Gln Ala Lys Gly Phe Ile Cys Glu Phe Cys Gln Asn 
                885                 890                 895     


Glu Asp Asp Ile Ile Phe Pro Phe Glu Leu His Lys Cys Arg Thr Cys 
            900                 905                 910         


Glu Glu Cys Lys Ala Cys Tyr His Lys Ala Cys Phe Lys Ser Gly Ser 
        915                 920                 925             


Cys Pro Arg Cys Glu Arg Leu Gln Ala Arg Arg Glu Ala Leu Ala Arg 
    930                 935                 940                 


Gln Ser Leu Glu Ser Tyr Leu Ser Asp Tyr Glu Glu Glu Pro Ala Glu 
945                 950                 955                 960 


Ala Leu Ala Leu Glu Ala Ala Val Leu Glu Ala Thr 
                965                 970         


<210>  5
<211>  1479
<212>  DNA
<213>  Mus musculus


<220>
<221>  Nucleotide sequence of murine ATG14L gene
<222>  (1)..(1479)

<400>  5
atggcgtctc ccagtgggaa gggatcttgg acgcccgagg ctcctggttt tgggccgcgg       60

gcgctagcac gggacctggt ggactcggtg gacgacgccg agggccttta cgtggctgtt      120

gagcggtgtc ctctgtgcaa caccactcgc cggcggttga cttgcgccaa gtgcgtccag      180

agcggtgatt tcgtctattt cgacggccgc gaccgggaga ggtttattga caagaaggaa      240

agactaagcc aacttaagaa caagcaagaa gaatttcaga aagaagtact aaaagctatg      300

gaaggaaagc ggcttacaga tcagttgaga tggaaaataa tgtcatgcaa gatgaggatt      360

gaacagctga agcaaacaat atgtaaagga aatgaggaaa tgaagaaaaa ttctgaaggt      420

ctcctcaaga acaaggaaaa gaaccagaag ctttacagcc gagcacagcg gcaccaagag      480

aaaaaggaga agattcagcg gcacaaccgc aagcttgggg acctggtgga gaagaagacc      540

attgacttga agagtcacta tgagcggttg gcgcggcttc gaaggtcaca catcctagag      600

ctcacctcca tcatattccc aatcgacgaa gtgaagactt ctgggagaga ccctgcagac      660

gtgtcttcag agactgacag tgccatgacc tcaagcatgg tgagcaagct tgctgaggcc      720

cggaggacaa cttacctctc tggaagatgg gtctgtgatg accacaatgg tgacaccagc      780

attagcatca caggcccgtg gattagccta ccaaacaacg gggactactc tgcttactac      840

aattgggtag aagagaagaa aacaacccaa ggacctgaca tggagcataa caaccccgcc      900

tacactatca gcgccgcgct gggctacgcc acgcagctcg tcaacattgt gtctcacata      960

cttgacatca atcttcccaa aaagctgtgc aacagcgagt tctgtggcga aaacctcagc     1020

aagcagaaac tgacacgcgc agtgaggaaa ctgaacgcaa acatccttta cctttgttct     1080

tctcagcatg taaatctgga tcagttgcaa ccactgcaca cactcaggaa cctgatgcac     1140

ttggtcagcc cgcgctctga gcacctaggc aggtcaggac cctttgaagt tcgagcagac     1200

ctcgaggagt ccatggaatt tgtggaccct ggagttgctg gagaatcaga cgcgagtgga     1260

gatgagcgtg taagcgatga ggagactgac ctgggcacag actgggagaa cctgccaagc     1320

ccccgattct gtgacatccc ttcccagccg gtggaagtgt cccagagcca gagcacccag     1380

gtgtccccac ccattgccag cagcagcgct ggtgggatga tctcctccgc tgcggcctcg     1440

gtgacctctt ggttcaaagc ttacactgga caccgctaa                            1479


<210>  6
<211>  1479
<212>  DNA
<213>  Homo sapiens


<220>
<221>  Nucleotide sequence of human ATG14L gene
<222>  (1)..(1479)

<400>  6
atggcgtctc ccagtgggaa gggagcccgg gcgctggagg ctcctggctg cgggccccgg       60

ccgctcgccc gggacctggt ggactccgtg gacgatgcgg aggggctgta cgtggctgtg      120

gagcgctgcc cgctgtgcaa cactacccgc cggcggctga cctgcgccaa atgcgttcag      180

agcggcgatt tcgtctactt cgacggccgc gaccgggaga ggtttatcga caagaaggaa      240

aggttaagcc gacttaagag caagcaagaa gaatttcaga aagaagtgtt aaaagctatg      300

gaaggaaaat ggataacaga tcagttgaga tggaaaataa tgtcctgcaa gatgaggatt      360

gaacagttaa aacaaacaat atgtaaagga aatgaagaaa tggagaaaaa ttctgaaggc      420

cttctcaaaa ccaaggaaaa gaatcagaag ctttacagtc gagcacaacg gcaccaagag      480

aaaaaggaga agattcagag gcataatcgc aaacttggtg acctggtaga aaaaaagacc      540

attgacttaa gaagtcatta tgagcgtctg gcaaatcttc gacgatccca tatattagag      600

ctcacctctg tcatttttcc aatcgaggaa gtaaagacgg gtgtgagaga ccccgcagat      660

gtgtcttcag agagtgacag tgccatgacc tccagcactg tgagcaagct tgctgaagcc      720

cggaggacaa cttacctctc aggacgatgg gtctgtgacg atcacaacgg agacaccagc      780

attagcatta cagggccttg gattagcctc cctaacaatg gggactactc tgcctactac      840

agctgggtgg aggagaagaa aacaacccag gggcctgaca tggagcagag taaccctgcc      900

tacaccatca gtgctgcgct gtgctatgca actcagctgg tcaacattct gtctcatata      960

cttgatgtaa atcttcccaa aaagctctgc aacagtgaat tttgtggcga aaatctaagc     1020

aagcagaaat ttactcgagc agtgaagaaa ctgaatgcaa atattcttta cctttgtttt     1080

tctcagcatg taaatttaga tcaattacaa ccactgcata ccctcaggaa tctaatgtac     1140

ctggtcagtc caagctctga acacctaggc aggtcagggc cctttgaagt acgagcagac     1200

cttgaggagt ccatggaatt tgtggatccc ggagttgctg gagaatcaga tgagagcgga     1260

gatgagcgcg tcagcgatga agaaaccgac ctgggcacag actgggagaa cttgcctagt     1320

ccccggtttt gtgatatccc ttcccagtct gtggaagtct cccagagtca gagcacccag     1380

gcgtccccac ccatcgcgag cagcagtgca ggtgggatga tctcctctgc agcagcctcg     1440

gtgacctcct ggtttaaagc ttacactgga caccgttaa                            1479


<210>  7
<211>  2826
<212>  DNA
<213>  Mus musculus


<220>
<221>  Nucleotide sequence of murine Rubicon gene
<222>  (1)..(2826)

<400>  7
atgcgtccgg agggcgcggg aatggatctt ggcggcggcg atggggagcg tctgctagag       60

aagagcagga gggagcactg gcagctgctg ggtaatttga agacgactgt ggaaggtttg      120

gtgtcagcca actgccccaa tgtctggtcc aagtatggtg gcctggagcg gctgtgcagg      180

gacatgcaga acatcctgta tcatgggctc atccatgacc aggtgtgttg ccgccaggct      240

gattactggc agtttgtgaa agacattcgg tggctcagcc cgcactcagc ccttcacgtg      300

gagaagttca tcagtttgca tgagagcgac cagagcgaca ctgacagcgt gagtgagcgt      360

gctgttgcag agctgtggct gcagcatagc ctgcagtgcc actgcctctc agcccagctc      420

cggcctctgc tcggggacag acagtacatc agaaaattct acacagaaac tgccttcctg      480

ctgagtgacg cccacgtcac agccatgctc cagtgcctgg aagcagtgga acagaacaac      540

ccccgtcttc tggctcagat cgatgcatcc atgtttgcca gaaagcagga gagcccgctg      600

ctggtcacaa agagccagag tctgaccgct ctgcctggtt ccacatacac ccctccagct      660

agctatgctc agcattccta ctttgggtcc tcctccagcc ttcagtctat gccacagtcc      720

agccacagct cagagagaag atctacttcc ttttcactct ctggcccttc ctggcaacct      780

caagaagaca gagaatgcct ctcaccagca gagactcaaa ccaccccagc tccgctgcct      840

tcagactcta ctctagccca ggattcccca ctgacagcac aggagatgag cgacagcact      900

ctgactagcc ccctagaggc atcctgggtc agcagccaga atgactcccc aagtgatgtc      960

agtgaggggc ccgagtacct ggccattggc aacccagccc ctcatggccg gactgccagt     1020

tgtgagagtc acagcagcaa cggcgagagc agcagctctc acttgttctc ctccagcagc     1080

tctcaaaagc tggagtctgc tgcctcttct ctaggggacc aagaggaagg caggcagagt     1140

caggcaggca gcgtccttcg caggtccagc ttctcagaag ggcagacagc ccctgtcgcc     1200

agcgggacaa agaagagcca tattcgctcc cactcggaca ccaacattgc ctccagagga     1260

gccgcagagg gtggtcagta cctctgctca ggagaaggca tgtttagaag accatcagaa     1320

ggacagtccc tcatcagtta cctctctgag caagactttg gcagctgtgc agacctggaa     1380

aaggaaaacg cccacttcag catctccgag tccttgattg ccgccattga gctgatgaag     1440

tgcaacatga tgagccagtg tctagaagag gaggaagtag aggaggaaga tagtgaccga     1500

gagatccagg aactgaagca gaagatccgc cttcggcgcc agcagatccg caccaaaaac     1560

ctgctccctg cgtaccggga gactgagaat ggaagcttcc gggtcacctc cagcagctcc     1620

cagttcagtt cacgggattc gacgcagctc tctgagtccg gctctgctga ggatgctgac     1680

gacttggaaa tccaagacgc tgacatccgg aggagtgcag tctcaaacgg caaatcatcc     1740

ttctcccaga atctctcgca ctgcttcctg cactccacat cggctgaggc agtggccatg     1800

gggcttctga agcagtttga ggggatgcag cttccagctg cctcggagct cgagtggcta     1860

gtcccagagc atgatgctcc acagaagctc ctacccatcc ccgactccct gcccatctca     1920

ccagatgacg ggcagcacgc ggacatctac aagctgcgaa tccgcgtccg tggcaacctg     1980

gagtgggctc cgccccggcc gcagatcatt tttaatgttc atccagcccc cacgaggaag     2040

attgccgtgg ccaagcagaa ttaccgctgt gcgggatgtg gcatccggac ggaccccgac     2100

tatatcaagc ggctgcggta ctgtgagtac ctaggcaagt acttctgcca gtgctgccac     2160

gagaacgccc agatggtcgt ccccagccgc attctgcgca aatgggactt cagcaagtac     2220

tatgtcagca acttctccaa ggacctgctc ctgaagatct ggaatgatcc tctcttcaat     2280

gtgcaggaca tcaatagcgc actctacagg aaggtcaagc tgcttaacca agtccggctg     2340

ctgcgggttc agctgtacca catgaagaac atgtttaaga catgccgact ggccaaagag     2400

ctcctggatt cctttgacgt ggttccaggc cacctgacag aggacctcca tctgtactcg     2460

ctgagtgacc tgactgcaac caagaaggga gaactggggc cccggctggc ggagctcact     2520

agagcgggag ccgcccacgt ggagagatgc atgctgtgtc aggccaaggg cttcatctgt     2580

gaattctgtc agaatgagga ggatgtcatc tttccttttg agctgcataa gtgccggact     2640

tgtgaagagt gtaaagcgtg ttaccataaa acttgcttca agtctggacg ctgcccccgg     2700

tgtgagcggc tgcaggcccg acgggagctg ctggccaagc agagcctgga gtcctacctg     2760

tctgactatg aggaggagcc cacagaagcc ttggctctag aggccaccgt cctagagacc     2820

acctga                                                                2826


<210>  8
<211>  2919
<212>  DNA
<213>  Homo sapiens


<220>
<221>  Nucleotide sequence of human Rubicon gene
<222>  (1)..(2919)

<400>  8
atgcggccgg agggcgcggg aatggagctc ggaggcggcg aggagcgcct gcctgaggag       60

agcaggaggg agcactggca gttgctgggt aatttgaaga cgacggtgga gggtttggta      120

tcaaccaaca gccccaacgt ctggtctaag tatggtggct tggagcggct ttgcagggac      180

atgcagagca tcctctatca cgggcttatc cgtgaccagg cgtgccgccg ccagacggat      240

tactggcagt tcgtgaaaga catccggtgg ctcagtcccc actcagccct tcacgtggag      300

aagttcatca gcgtgcacga gaacgaccag agcagtgctg atggtgccag tgaacgtgct      360

gttgccgagc tgtggctgca gcacagcctg cagtaccact gcctctcagc ccagctccgg      420

cccctgctcg gggatagaca gtatatcaga aaattctaca cagatgctgc cttcctgcta      480

agtgacgctc atgtcacggc catgctgcag tgcctggaag cagtggaaca gaacaacccc      540

cgcctcctgg ctcagatcga tgcgtccatg tttgccagaa agcacgagag cccgctcctg      600

gtgacaaaga gccagagcct gacagccctg cccagttcca catacacccc tccaaacagc      660

tatgctcagc attcctactt tgggtccttc tctagcctcc accaatccgt gcccaacaat      720

ggctcagaga gaagatctac ttcctttcca ctctctggcc ctccccggaa acctcaagaa      780

agcagagggc acgtctcacc agcagaggat caaaccatcc aagccccccc agtttcagtc      840

tctgcactag ccagggattc ccctttgacc ccaaatgaaa tgagctccag tactctgacc      900

agccccatag aggcatcctg ggtcagcagc cagaatgatt ccccaggtga tgccagtgag      960

gggcctgagt acctggccat tggcaacttg gacccccgag gccggactgc cagctgtcag     1020

agtcacagca gcaatgccga gagcagcagt tccaatttgt tctcctccag cagctcccag     1080

aagccagatt ctgctgcctc ttccttaggg gaccaggaag gaggtgggga gagccagctg     1140

tccagtgtcc tccgcaggtc cagcttctca gaggggcaga cactcactgt caccagtggg     1200

gcaaagaaaa gccacattcg ctcccattcg gataccagca ttgcctccag gggagctcca     1260

gaatcctgca atgataaggc gaagttgaga ggccctttgc cctactctgg tcaaagcagt     1320

gaagtcagca cacccagctc tctgtacatg gaatatgaag gtggtcggta cctgtgctca     1380

ggggaaggca tgttccgaag accatcagaa ggacagtccc tcatcagcta cctctctgag     1440

caagacttcg gcagctgtgc cgacctggaa aaggagaatg cccacttcag catctcagag     1500

tccttaattg ctgccatcga gctaatgaag tgcaacatga tgagccagtg cctagaggag     1560

gaggaagtgg aagaggaaga cagtgataga gagatccagg agctgaagca gaagatccgc     1620

cttcggcgcc agcaaatccg caccaagaac ctgctcccca tgtaccagga ggctgagcac     1680

ggaagctttc gggtcacctc cagcagctcc cagttcagct cacgtgattc ggcacagctc     1740

tctgactctg gctctgctga tgaggttgat gaatttgaaa tccaagatgc tgacatcaga     1800

aggaacacag cctcaagcag caaatccttc gtttcctccc agtccttctc ccactgcttc     1860

ctgcactcca cgtctgctga ggcggtggcc atggggctcc tgaagcagtt tgaggggatg     1920

cagcttccag ccgcctcgga gctggagtgg cttgtcccgg agcatgatgc ccctcagaag     1980

ctcctgccca ttcctgactc actgcccatc tcaccggatg acgggcagca cgctgacatc     2040

tacaagctgc ggattcgtgt tcgtggcaac ttggagtggg ccccgccccg gcctcagata     2100

atttttaatg ttcatccagc cccaacgagg aaaattgccg tggccaagca gaattaccgc     2160

tgtgcaggat gtggcatccg gactgaccct gattacatca agcgactgcg gtactgtgag     2220

tacctgggca agtacttctg ccagtgctgc cacgagaatg cccagatggc catccccagc     2280

cgggttctgc gcaagtggga cttcagcaag tactacgtca gcaacttctc caaggacctg     2340

ctcattaaga tctggaatga tcctctcttc aacgtgcagg acataaacag tgccctctat     2400

aggaaggtca agctgctcaa tcaagtccgg ctgctgcggg tccagctgtg tcacatgaag     2460

aacatgttca agacttgccg actggccaag gagcttctgg attcctttga cacagtccca     2520

ggccacctga cagaggacct ccacctgtac tcactgaatg acctgactgc gaccaggaag     2580

ggggagctgg ggccccggct tgctgagctc accagggcag gggctaccca tgtggagaga     2640

tgcatgctct gccaagccaa aggcttcatc tgtgagttct gtcagaatga ggatgacatc     2700

atctttccct ttgagctcca taagtgccgg acctgtgaag agtgtaaagc gtgttaccat     2760

aaagcctgct tcaagtctgg aagctgtccg cgctgcgagc ggctgcaggc ccggcgggag     2820

gcactggcca ggcagagcct ggagtcttac ctgtcagact acgaggagga gcccgcggaa     2880

gcgctggccc tggaagccgc cgtcctggag gccacctga                            2919


<210>  9
<211>  450
<212>  PRT
<213>  Homo sapiens


<220>
<221>  Amino acid sequence of human Beclin protein
<222>  (1)..(450)

<400>  9

Met Glu Gly Ser Lys Thr Ser Asn Asn Ser Thr Met Gln Val Ser Phe 
1               5                   10                  15      


Val Cys Gln Arg Cys Ser Gln Pro Leu Lys Leu Asp Thr Ser Phe Lys 
            20                  25                  30          


Ile Leu Asp Arg Val Thr Ile Gln Glu Leu Thr Ala Pro Leu Leu Thr 
        35                  40                  45              


Thr Ala Gln Ala Lys Pro Gly Glu Thr Gln Glu Glu Glu Thr Asn Ser 
    50                  55                  60                  


Gly Glu Glu Pro Phe Ile Glu Thr Pro Arg Gln Asp Gly Val Ser Arg 
65                  70                  75                  80  


Arg Phe Ile Pro Pro Ala Arg Met Met Ser Thr Glu Ser Ala Asn Ser 
                85                  90                  95      


Phe Thr Leu Ile Gly Glu Ala Ser Asp Gly Gly Thr Met Glu Asn Leu 
            100                 105                 110         


Ser Arg Arg Leu Lys Val Thr Gly Asp Leu Phe Asp Ile Met Ser Gly 
        115                 120                 125             


Gln Thr Asp Val Asp His Pro Leu Cys Glu Glu Cys Thr Asp Thr Leu 
    130                 135                 140                 


Leu Asp Gln Leu Asp Thr Gln Leu Asn Val Thr Glu Asn Glu Cys Gln 
145                 150                 155                 160 


Asn Tyr Lys Arg Cys Leu Glu Ile Leu Glu Gln Met Asn Glu Asp Asp 
                165                 170                 175     


Ser Glu Gln Leu Gln Met Glu Leu Lys Glu Leu Ala Leu Glu Glu Glu 
            180                 185                 190         


Arg Leu Ile Gln Glu Leu Glu Asp Val Glu Lys Asn Arg Lys Ile Val 
        195                 200                 205             


Ala Glu Asn Leu Glu Lys Val Gln Ala Glu Ala Glu Arg Leu Asp Gln 
    210                 215                 220                 


Glu Glu Ala Gln Tyr Gln Arg Glu Tyr Ser Glu Phe Lys Arg Gln Gln 
225                 230                 235                 240 


Leu Glu Leu Asp Asp Glu Leu Lys Ser Val Glu Asn Gln Met Arg Tyr 
                245                 250                 255     


Ala Gln Thr Gln Leu Asp Lys Leu Lys Lys Thr Asn Val Phe Asn Ala 
            260                 265                 270         


Thr Phe His Ile Trp His Ser Gly Gln Phe Gly Thr Ile Asn Asn Phe 
        275                 280                 285             


Arg Leu Gly Arg Leu Pro Ser Val Pro Val Glu Trp Asn Glu Ile Asn 
    290                 295                 300                 


Ala Ala Trp Gly Gln Thr Val Leu Leu Leu His Ala Leu Ala Asn Lys 
305                 310                 315                 320 


Met Gly Leu Lys Phe Gln Arg Tyr Arg Leu Val Pro Tyr Gly Asn His 
                325                 330                 335     


Ser Tyr Leu Glu Ser Leu Thr Asp Lys Ser Lys Glu Leu Pro Leu Tyr 
            340                 345                 350         


Cys Ser Gly Gly Leu Arg Phe Phe Trp Asp Asn Lys Phe Asp His Ala 
        355                 360                 365             


Met Val Ala Phe Leu Asp Cys Val Gln Gln Phe Lys Glu Glu Val Glu 
    370                 375                 380                 


Lys Gly Glu Thr Arg Phe Cys Leu Pro Tyr Arg Met Asp Val Glu Lys 
385                 390                 395                 400 


Gly Lys Ile Glu Asp Thr Gly Gly Ser Gly Gly Ser Tyr Ser Ile Lys 
                405                 410                 415     


Thr Gln Phe Asn Ser Glu Glu Gln Trp Thr Lys Ala Leu Lys Phe Met 
            420                 425                 430         


Leu Thr Asn Leu Lys Trp Gly Leu Ala Trp Val Ser Ser Gln Phe Tyr 
        435                 440                 445             


Asn Lys 
    450 


<210>  10
<211>  448
<212>  PRT
<213>  Mus musculus


<220>
<221>  Amino acid sequence of murine Beclin protein
<222>  (1)..(448)

<400>  10

Met Glu Gly Ser Lys Ala Ser Ser Ser Thr Met Gln Val Ser Phe Val 
1               5                   10                  15      


Cys Gln Arg Cys Ser Gln Pro Leu Lys Leu Asp Thr Ser Phe Lys Ile 
            20                  25                  30          


Leu Asp Arg Val Thr Ile Gln Glu Leu Thr Ala Pro Leu Leu Thr Thr 
        35                  40                  45              


Ala Gln Ala Lys Pro Gly Glu Thr Gln Glu Glu Glu Ala Asn Ser Gly 
    50                  55                  60                  


Glu Glu Pro Phe Ile Glu Thr Arg Gln Asp Gly Val Ser Arg Arg Phe 
65                  70                  75                  80  


Ile Pro Pro Ala Arg Met Met Ser Thr Glu Ser Ala Asn Ser Phe Thr 
                85                  90                  95      


Leu Ile Gly Glu Ala Ser Asp Gly Gly Thr Met Glu Asn Leu Ser Arg 
            100                 105                 110         


Arg Leu Lys Val Thr Gly Asp Leu Phe Asp Ile Met Ser Gly Gln Thr 
        115                 120                 125             


Asp Val Asp His Pro Leu Cys Glu Glu Cys Thr Asp Thr Leu Leu Asp 
    130                 135                 140                 


Gln Leu Asp Thr Gln Leu Asn Val Thr Glu Asn Glu Cys Gln Asn Tyr 
145                 150                 155                 160 


Lys Arg Cys Leu Glu Ile Leu Glu Gln Met Asn Glu Asp Asp Ser Glu 
                165                 170                 175     


Gln Leu Gln Arg Glu Leu Lys Glu Leu Ala Leu Glu Glu Glu Arg Leu 
            180                 185                 190         


Ile Gln Glu Leu Glu Asp Val Glu Lys Asn Arg Lys Val Val Ala Glu 
        195                 200                 205             


Asn Leu Glu Lys Val Gln Ala Glu Ala Glu Arg Leu Asp Gln Glu Glu 
    210                 215                 220                 


Ala Gln Tyr Gln Arg Glu Tyr Ser Glu Phe Lys Arg Gln Gln Leu Glu 
225                 230                 235                 240 


Leu Asp Asp Glu Leu Lys Ser Val Glu Asn Gln Val Arg Tyr Ala Gln 
                245                 250                 255     


Ile Gln Leu Asp Lys Leu Lys Lys Thr Asn Val Phe Asn Ala Thr Phe 
            260                 265                 270         


His Ile Trp His Ser Gly Gln Phe Gly Thr Ile Asn Asn Phe Arg Leu 
        275                 280                 285             


Gly Arg Leu Pro Ser Val Pro Val Glu Trp Asn Glu Ile Asn Ala Ala 
    290                 295                 300                 


Trp Gly Gln Thr Val Leu Leu Leu His Ala Leu Ala Asn Lys Met Gly 
305                 310                 315                 320 


Leu Lys Phe Gln Arg Tyr Arg Leu Val Pro Tyr Gly Asn His Ser Tyr 
                325                 330                 335     


Leu Glu Ser Leu Thr Asp Lys Ser Lys Glu Leu Pro Leu Tyr Cys Ser 
            340                 345                 350         


Gly Gly Leu Arg Phe Phe Trp Asp Asn Lys Phe Asp His Ala Met Val 
        355                 360                 365             


Ala Phe Leu Asp Cys Val Gln Gln Phe Lys Glu Glu Val Glu Lys Gly 
    370                 375                 380                 


Glu Thr Arg Phe Cys Leu Pro Tyr Arg Met Asp Val Glu Lys Gly Lys 
385                 390                 395                 400 


Ile Glu Asp Thr Gly Gly Ser Gly Gly Ser Tyr Ser Ile Lys Thr Gln 
                405                 410                 415     


Phe Asn Ser Glu Glu Gln Trp Thr Lys Ala Leu Lys Phe Met Leu Thr 
            420                 425                 430         


Asn Leu Lys Trp Gly Leu Ala Trp Val Ser Ser Gln Phe Tyr Asn Lys 
        435                 440                 445             


<210>  11
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthesized sequence


<220>
<221>  Nucleotide sequence of siRNA targeted to ATG14L
<222>  (1)..(25)

<400>  11
uuugcguuca guuuccucac ugcgc                                             25


<210>  12
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthesized sequence


<220>
<221>  Nucleotide sequence of siRNA targeted to Rubicon
<222>  (1)..(19)

<400>  12
gccuucaguc uaugccaca                                                    19


<210>  13
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthesized sequence


<220>
<221>  Nucleotide sequence of EGFP forward primer for PCR reaction
<222>  (1)..(23)

<400>  13
cctacggcgt gcagtgcttc agc                                               23


<210>  14
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthesized sequence


<220>
<221>  Nucleotide sequence of EGFP reverse primer for PCR reaction
<222>  (1)..(25)

<400>  14
cggcgagctg cacgctgccg tcctc                                             25


