                              Sequence Listing

<110> GENENTECH, INC., et al.

<120> METHODS FOR INHIBITING OCULAR ANGIOGENESIS

<130> P4264R1 WO


<150> US 61/095,757
<151> 2008-09-10

<150> US 61/103,502
<151> 2008-10-07

<150> US 61/234,519
<151> 2009-08-17

<160> 5

<210> 1
<211> 305
<212> PRT
<213> Homo sapiens

<400> 1
 Met Ala Arg Glu Asp Ser Val Lys Cys Leu Arg Cys Leu Leu Tyr
   1               5                  10                  15

 Ala Leu Asn Leu Leu Phe Trp Leu Met Ser Ile Ser Val Leu Ala
                  20                  25                  30

 Val Ser Ala Trp Met Arg Asp Tyr Leu Asn Asn Val Leu Thr Leu
                  35                  40                  45

 Thr Ala Glu Thr Arg Val Glu Glu Ala Val Ile Leu Thr Tyr Phe
                  50                  55                  60

 Pro Val Val His Pro Val Met Ile Ala Val Cys Cys Phe Leu Ile
                  65                  70                  75

 Ile Val Gly Met Leu Gly Tyr Cys Gly Thr Val Lys Arg Asn Leu
                  80                  85                  90

 Leu Leu Leu Ala Trp Tyr Phe Gly Ser Leu Leu Val Ile Phe Cys
                  95                 100                 105

 Val Glu Leu Ala Cys Gly Val Trp Thr Tyr Glu Gln Glu Leu Met
                 110                 115                 120

 Val Pro Val Gln Trp Ser Asp Met Val Thr Leu Lys Ala Arg Met
                 125                 130                 135

 Thr Asn Tyr Gly Leu Pro Arg Tyr Arg Trp Leu Thr His Ala Trp
                 140                 145                 150

 Asn Phe Phe Gln Arg Glu Phe Lys Cys Cys Gly Val Val Tyr Phe
                 155                 160                 165

 Thr Asp Trp Leu Glu Met Thr Glu Met Asp Trp Pro Pro Asp Ser
                 170                 175                 180

 Cys Cys Val Arg Glu Phe Pro Gly Cys Ser Lys Gln Ala His Gln
                 185                 190                 195

 Glu Asp Leu Ser Asp Leu Tyr Gln Glu Gly Cys Gly Lys Lys Met
                 200                 205                 210

 Tyr Ser Phe Leu Arg Gly Thr Lys Gln Leu Gln Val Leu Arg Phe
                 215                 220                 225

 Leu Gly Ile Ser Ile Gly Val Thr Gln Ile Leu Ala Met Ile Leu
                 230                 235                 240

 Thr Ile Thr Leu Leu Trp Ala Leu Tyr Tyr Asp Arg Arg Glu Pro
                 245                 250                 255

 Gly Thr Asp Gln Met Met Ser Leu Lys Asn Asp Asn Ser Gln His
                 260                 265                 270

 Leu Ser Cys Pro Ser Val Glu Leu Leu Lys Pro Ser Leu Ser Arg
                 275                 280                 285

 Ile Phe Glu His Thr Ser Met Ala Asn Ser Phe Asn Thr His Phe
                 290                 295                 300

 Glu Met Glu Glu Leu
                 305

<210> 2
<211> 257
<212> PRT
<213> Mus musculus

<400> 2
 Met Ala Arg Glu Asp Ser Val Lys Cys Leu Arg Cys Leu Leu Tyr
   1               5                  10                  15

 Ala Leu Asn Leu Leu Phe Trp Leu Met Ser Ile Ser Val Leu Ala
                  20                  25                  30

 Val Ser Ala Trp Met Arg Asp Tyr Leu Asn Asn Val Leu Thr Leu
                  35                  40                  45

 Thr Ala Glu Thr Arg Val Glu Glu Ala Val Ile Leu Thr Tyr Phe
                  50                  55                  60

 Pro Val Val His Pro Val Met Ile Ala Val Cys Cys Phe Leu Ile
                  65                  70                  75

 Ile Val Gly Met Leu Gly Tyr Cys Gly Thr Val Lys Arg Asn Leu
                  80                  85                  90

 Leu Leu Leu Ala Trp Tyr Phe Gly Thr Leu Leu Val Ile Phe Cys
                  95                 100                 105

 Val Glu Leu Ala Cys Gly Val Trp Thr Tyr Glu Gln Glu Val Met
                 110                 115                 120

 Val Pro Val Gln Trp Ser Asp Met Val Thr Leu Lys Ala Arg Met
                 125                 130                 135

 Thr Asn Tyr Gly Leu Pro Arg Tyr Arg Trp Leu Thr His Ala Trp
                 140                 145                 150

 Asn Tyr Phe Gln Arg Glu Gly Cys Gly Lys Lys Met Tyr Ser Phe
                 155                 160                 165

 Leu Arg Gly Thr Lys Gln Leu Gln Val Leu Arg Phe Leu Gly Ile
                 170                 175                 180

 Ser Ile Gly Val Thr Gln Ile Leu Ala Met Ile Leu Thr Ile Thr
                 185                 190                 195

 Leu Leu Trp Ala Leu Tyr Tyr Asp Arg Arg Glu Pro Gly Thr Asp
                 200                 205                 210

 Gln Met Leu Ser Leu Lys Asn Asp Thr Ser Gln His Leu Ser Cys
                 215                 220                 225

 His Ser Val Glu Leu Leu Lys Pro Ser Leu Ser Arg Ile Phe Glu
                 230                 235                 240

 His Thr Ser Met Ala Asn Ser Phe Asn Thr His Phe Glu Met Glu
                 245                 250                 255

 Glu Leu
        

<210> 3
<211> 133
<212> PRT
<213> Homo sapiens

<400> 3
 Met Arg Lys His Val Leu Ala Ala Ser Phe Ser Met Leu Ser Leu
   1               5                  10                  15

 Leu Val Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe
                  20                  25                  30

 Ile Met Asp Ser Asp Pro Arg Arg Cys Met Arg His His Tyr Val
                  35                  40                  45

 Asp Ser Ile Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val
                  50                  55                  60

 Leu Leu Ala Arg Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser
                  65                  70                  75

 Glu Pro Leu Val Ser Phe Ser Thr Val Leu Lys Gln Pro Phe Arg
                  80                  85                  90

 Ser Ser Cys His Cys Cys Arg Pro Gln Thr Ser Lys Leu Lys Ala
                  95                 100                 105

 Leu Arg Leu Arg Cys Ser Gly Gly Met Arg Leu Thr Ala Thr Tyr
                 110                 115                 120

 Arg Tyr Ile Leu Ser Cys His Cys Glu Glu Cys Asn Ser
                 125                 130            

<210> 4
<211> 131
<212> PRT
<213> Mus musculus

<400> 4
 Met Arg Asn His Val Leu Ala Ala Ser Ile Ser Met Leu Ser Leu
   1               5                  10                  15

 Leu Ala Ile Met Gly Asp Thr Asp Ser Lys Thr Asp Ser Ser Phe
                  20                  25                  30

 Leu Met Asp Ser Gln Arg Cys Met Arg His His Tyr Val Asp Ser
                  35                  40                  45

 Ile Ser His Pro Leu Tyr Lys Cys Ser Ser Lys Met Val Leu Leu
                  50                  55                  60

 Ala Arg Cys Glu Gly His Cys Ser Gln Ala Ser Arg Ser Glu Pro
                  65                  70                  75

 Leu Val Ser Phe Ser Thr Val Leu Lys Gln Pro Phe Arg Ser Ser
                  80                  85                  90

 Cys His Cys Cys Arg Pro Gln Thr Ser Lys Leu Lys Ala Leu Arg
                  95                 100                 105

 Leu Arg Cys Ser Gly Gly Met Arg Leu Thr Ala Thr Tyr Arg Tyr
                 110                 115                 120

 Ile Leu Ser Cys His Cys Glu Glu Cys Ser Ser
                 125                 130    

<210> 5
<211> 14
<212> PRT
<213> Homo sapiens

<400> 5
 Cys Arg Arg Glu Pro Gly Thr Asp Gln Met Met Ser Leu Lys
                   5                  10                

