                         SEQUENCE LISTING

<110>  University of Rochester
       Federoff, Howard J.
 
<120>  Nurr 1 Interacting Protein (NuIP)

<130>  20724-0031WO1

<150>  61/095,540
<151>  2008-09-09

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  1093
<212>  PRT
<213>  Mus musculus

<400>  1

Met Ala Ser Val Pro Ala Glu Ala Glu Thr Arg Gln Arg Leu Leu Arg 
1               5                   10                  15      


Thr Val Lys Lys Glu Val Lys Gln Ile Met Glu Glu Ala Val Thr Arg 
            20                  25                  30          


Lys Phe Val His Glu Asp Ser Ser His Ile Ile Ser Phe Cys Ala Ala 
        35                  40                  45              


Val Glu Ala Cys Val Leu His Gly Leu Arg Arg Arg Ala Ala Gly Phe 
    50                  55                  60                  


Leu Arg Ser Asn Lys Ile Ala Ala Leu Phe Met Lys Val Gly Lys Gly 
65                  70                  75                  80  


Phe Pro Pro Ala Glu Glu Leu Ser Arg Lys Val Gln Glu Leu Glu Gln 
                85                  90                  95      


Leu Ile Glu Ser Ala Arg Asn Gln Ile Gln Gly Leu Gln Glu Asn Val 
            100                 105                 110         


Arg Lys Leu Pro Lys Leu Pro Asn Leu Ser Pro Leu Ala Ile Lys His 
        115                 120                 125             


Leu Trp Ile Arg Thr Ala Leu Phe Glu Arg Val Leu Asp Lys Ile Val 
    130                 135                 140                 


His Tyr Leu Val Glu Asn Ser Ser Lys Tyr Tyr Glu Lys Glu Ala Leu 
145                 150                 155                 160 


Leu Met Asp Pro Val Asp Gly Pro Ile Leu Ala Ser Leu Leu Val Gly 
                165                 170                 175     


Pro Cys Ala Leu Glu Tyr Thr Lys Met Lys Thr Ala Asp His Phe Trp 
            180                 185                 190         


Thr Asp Pro Ser Ala Asp Glu Leu Val Gln Arg His Arg Ile His Ser 
        195                 200                 205             


Ser His Leu Arg Gln Asp Ser Pro Thr Lys Arg Pro Ala Leu Cys Ile 
    210                 215                 220                 


Gln Lys Arg His Ser Ser Gly Ser Met Asp Asp Arg Pro Ser Ile Ser 
225                 230                 235                 240 


Ala Arg Asp Tyr Val Glu Ser Leu His Gln Asn Ser Arg Ala Thr Leu 
                245                 250                 255     


Leu Tyr Gly Lys Asn Asn Val Leu Val Gln Pro Arg Asp Asp Met Glu 
            260                 265                 270         


Ala Val Pro Gly Tyr Leu Ser Leu His Gln Thr Ala Asp Val Met Thr 
        275                 280                 285             


Leu Lys Trp Thr Pro Asn Gln Leu Met Asn Gly Ser Val Gly Asp Leu 
    290                 295                 300                 


Asp Tyr Glu Lys Ser Val Tyr Trp Asp Tyr Ala Val Thr Ile Arg Leu 
305                 310                 315                 320 


Glu Glu Ile Val Tyr Leu His Cys His Gln Gln Val Asp Ser Gly Gly 
                325                 330                 335     


Thr Val Val Leu Val Ser Gln Asp Gly Ile Gln Arg Pro Pro Phe Arg 
            340                 345                 350         


Phe Pro Lys Gly Gly His Leu Leu Gln Phe Leu Ser Cys Leu Glu Asn 
        355                 360                 365             


Gly Leu Leu Pro His Gly Gln Leu Asp Pro Pro Leu Trp Ser Gln Arg 
    370                 375                 380                 


Gly Lys Gly Lys Val Phe Pro Lys Leu Arg Lys Arg Ser Pro Gln Gly 
385                 390                 395                 400 


Ser Ser Glu Ser Thr Ser Ser Asp Lys Glu Asp Asp Glu Ala Thr Asp 
                405                 410                 415     


Tyr Val Phe Arg Ile Ile Tyr Pro Gly Thr Gln Ser Glu Phe Val Pro 
            420                 425                 430         


Gln Asp Leu Met Asp Val Ser Met Asn Asn Leu Pro Pro Leu Trp Gln 
        435                 440                 445             


Pro Ser Pro Arg Lys Ser Ser Cys Ser Ser Cys Ser Gln Ser Gly Ser 
    450                 455                 460                 


Ala Asp Gly Gly Ser Thr Asn Gly Cys Asn His Glu Arg Ala Pro Leu 
465                 470                 475                 480 


Lys Leu Leu Cys Asp Asn Met Lys Tyr Gln Ile Leu Ser Arg Ala Phe 
                485                 490                 495     


Tyr Gly Trp Leu Ala Tyr Cys Arg His Leu Ser Thr Val Arg Thr His 
            500                 505                 510         


Leu Ser Ala Leu Val Asn His Met Ile Val Ser Pro Asp Leu Pro Cys 
        515                 520                 525             


Asp Ala Gly Gln Gly Leu Thr Ala Ser Ile Trp Glu Lys Tyr Ile Gln 
    530                 535                 540                 


Asp Ser Thr Thr Tyr Pro Glu Gln Glu Leu Leu Arg Leu Ile Tyr Tyr 
545                 550                 555                 560 


Gly Gly Val Gln Pro Glu Ile Arg Arg Ala Val Trp Pro Phe Leu Leu 
                565                 570                 575     


Gly His Tyr Gln Phe Gly Met Thr Glu Met Glu Arg Lys Glu Val Asp 
            580                 585                 590         


Glu Gln Ile His Ala Cys Tyr Ala Gln Thr Met Ser Glu Trp Leu Gly 
        595                 600                 605             


Cys Glu Ala Ile Val Arg Gln Arg Glu Arg Glu Ser His Ala Ala Ala 
    610                 615                 620                 


Leu Ala Lys Cys Ser Ser Gly Ala Ser Leu Asp Ser His Leu His Arg 
625                 630                 635                 640 


Met Leu His Arg Asp Ser Thr Ile Ser Asn Glu Ser Ser Gln Ser Cys 
                645                 650                 655     


Ser Ser Gly Arg Gln Asn Leu Arg Leu Gln Ser Asp Ser Ser Ser Ser 
            660                 665                 670         


Thr Gln Val Phe Glu Ser Val Asp Glu Val Glu Gln Thr Glu Ala Glu 
        675                 680                 685             


Gly Arg Ser Glu Glu Lys His Pro Lys Ile Pro Asn Gly Asn Pro Ala 
    690                 695                 700                 


Asn Gly Thr Cys Ser Pro Asp Ser Gly His Pro Ser Ser His Asn Phe 
705                 710                 715                 720 


Ser Ser Gly Leu Ser Glu His Ser Glu Pro Ser Leu Ser Thr Glu Asp 
                725                 730                 735     


Ser Val Leu Asp Ala Gln Arg Ser Leu Pro Ala Val Phe Arg Pro Gly 
            740                 745                 750         


Asp Ser Ser Val Glu Asp Gly Gln Ser Ser Glu Ala Thr Thr Ser Arg 
        755                 760                 765             


Asp Glu Ala Pro Arg Glu Glu Leu Ala Val Gln Asp Ser Leu Glu Ser 
    770                 775                 780                 


Asp Leu Leu Ala Asn Glu Ser Leu Glu Glu Phe Met Ser Ile Pro Gly 
785                 790                 795                 800 


Ser Leu Asp Val Ala Leu Pro Glu Lys Asp Gly Ala Val Met Asp Gly 
                805                 810                 815     


Trp Pro Gly Glu Ala Asp Lys Pro Ser Arg Ala Asp Ser Glu Asp Asn 
            820                 825                 830         


Leu Ser Glu Glu Pro Glu Met Glu Ser Leu Phe Pro Ala Leu Ala Ser 
        835                 840                 845             


Leu Ala Val Thr Ser Ser Ala Asn Asn Glu Ala Ser Pro Val Ser Ser 
    850                 855                 860                 


Ser Gly Val Thr Tyr Ser Pro Glu Leu Leu Asp Leu Tyr Thr Val Asn 
865                 870                 875                 880 


Leu His Arg Ile Glu Lys Asp Val Gln Arg Cys Asp Arg Ser Tyr Trp 
                885                 890                 895     


Tyr Phe Thr Ala Ala Asn Leu Glu Lys Leu Arg Asn Ile Met Cys Ser 
            900                 905                 910         


Tyr Ile Trp Gln His Ile Glu Ile Gly Tyr Val Gln Gly Met Cys Asp 
        915                 920                 925             


Leu Leu Ala Pro Leu Leu Val Ile Leu Asp Asp Glu Ala Leu Ala Phe 
    930                 935                 940                 


Ser Cys Phe Thr Glu Leu Met Lys Arg Met Asn Gln Asn Phe Pro His 
945                 950                 955                 960 


Gly Gly Ala Met Asp Thr His Phe Ala Asn Met Arg Ser Leu Ile Gln 
                965                 970                 975     


Ile Leu Asp Ser Glu Leu Phe Glu Leu Met His Gln Asn Gly Asp Tyr 
            980                 985                 990         


Thr His Phe Tyr Phe Cys Tyr Arg  Trp Phe Leu Leu Asp  Phe Lys Arg 
        995                 1000                 1005             


Glu Leu  Val Tyr Asp Asp Val  Phe Ser Val Trp Glu  Thr Ile Trp 
    1010                 1015                 1020             


Ala Ala  Lys His Val Ser Ser  Ala His Tyr Val Leu  Phe Ile Ala 
    1025                 1030                 1035             


Leu Ala  Leu Val Glu Val Tyr  Arg Asp Ile Ile Leu  Glu Asn Asn 
    1040                 1045                 1050             


Met Asp  Phe Thr Asp Ile Ile  Lys Phe Phe Asn Glu  Met Ala Glu 
    1055                 1060                 1065             


Arg His  Asn Ala Lys Gln Ile  Leu Gln Leu Ala Arg  Asp Leu Val 
    1070                 1075                 1080             


His Lys  Val Gln Ile Leu Ile  Glu Asn Lys 
    1085                 1090             


<210>  2
<211>  3282
<212>  DNA
<213>  Mus musculus

<400>  2
atggcttcgg tccctgcgga ggccgagacc cgccagaggc tgctgcgcac tgtgaagaag       60

gaggtgaagc agatcatgga agaagccgtt accagaaagt tcgtccacga ggacagcagc      120

cacatcatct ccttctgtgc ggccgtggag gcctgcgtgc tgcacgggct gcggcggagg      180

gcggccggct tcctgcgaag caacaagatc gcggcgctct tcatgaaggt gggcaaaggc      240

ttccctccgg ccgaggagct gagccgcaag gtccaggaac tggagcaact cattgagagc      300

gcgcgaaacc agatccaggg cctgcaagag aacgtgcgga agctgccgaa gctgcctaac      360

ctgtccccgc tggccatcaa gcacctgtgg atccgcaccg ccctgttcga gagggtcctg      420

gacaaaatcg tccactacct ggtggaaaac agcagtaaat actacgagaa ggaggcactc      480

ttgatggacc cggtggacgg acccatcctg gcctctttgt tggtggggcc atgtgccctg      540

gagtatacca agatgaagac tgcagatcac ttctggactg acccctcagc cgacgagctg      600

gtccagagac accggatcca cagctcacat ctgagacagg actcgcccac caagcggcca      660

gcgctctgta tccagaagag gcattccagt ggcagcatgg acgaccggcc atctatctct      720

gcccgggact atgtagaatc tctgcaccag aactccaggg ccaccctgct ctatggaaag      780

aacaatgttc tggttcagcc aagggatgac atggaggccg tgccagggta cctgtctctg      840

caccagacag cggatgtcat gaccttgaag tggacaccca atcagctgat gaacgggtct      900

gtgggggatc tggactacga gaagagtgtc tactgggact acgctgtgac catccgctta      960

gaggagatag tttacctgca ctgccatcaa caagtggaca gcggcgggac tgtcgtgctg     1020

gtgagccagg atggaatcca gaggccaccc ttccgcttcc ccaagggcgg gcacctgcta     1080

cagttcctct cctgtctgga gaatgggctg cttccgcacg ggcagctgga cccgccgctt     1140

tggtcacagc gaggaaaggg gaaggtattt cctaagttgc gcaagcgcag cccacagggg     1200

tcctccgagt ccacgtcttc agacaaggag gacgacgaag ccacggatta cgtgttccgc     1260

atcatctacc ctggcacgca gtctgaattc gtgccccagg acctaatgga tgtctctatg     1320

aacaaccttc cacccctatg gcaacccagt cctcggaagt cctcctgctc ttcctgttca     1380

caaagcggct cagctgacgg cggctcaacc aatggctgta accatgagag ggccccactg     1440

aaactgctgt gtgataacat gaagtaccag atcctctcca gagccttcta tggatggctc     1500

gcctactgca gacacctgtc caccgtgagg acccacctgt cagccctggt caatcacatg     1560

atcgtgtctc cagacctgcc ctgtgacgct gggcaagggt tgacagccag catctgggaa     1620

aaatacatcc aggacagcac gacctacccg gagcaggagc tgctgcgtct catctactat     1680

ggaggtgtcc agcctgagat ccgcagggca gtgtggccct tcctcctcgg ccactaccag     1740

tttgggatga cagagatgga gaggaaagag gtagacgaac agatccatgc ctgctacgca     1800

caaaccatgt cggagtggct gggctgtgaa gctatcgtga gacagaggga gcgggagtcc     1860

cacgcggctg ccctggccaa gtgctcttca ggagccagcc tggacagcca ccttcaccgg     1920

atgctgcacc gggactccac catcagcaat gagtcatccc agagctgcag ctcaggccgc     1980

cagaacctcc gactgcagag cgactccagc agcagcacac aggtatttga gtctgtggat     2040

gaggtggagc agacagaggc agaaggcagg tcagaagaaa aacatcccaa aatccccaat     2100

gggaacccag ccaacggcac ttgctcccca gactccggac acccttcctc ccacaacttc     2160

tcctctggtc tctccgagca ctctgagccc agtcttagca ctgaagacag cgtcttggat     2220

gcccaacgca gccttccagc tgtgtttcgg cctggggaca gcagcgtgga agatgggcag     2280

agcagcgaag ccaccacatc ccgggacgag gcccctcggg aggagctggc cgtgcaagat     2340

agccttgaga gtgacctcct tgccaacgag agcttggagg agttcatgtc tatccctggc     2400

agcctggacg tggccctacc tgagaaggat ggcgcggtga tggacggctg gcccggtgag     2460

gcggacaagc ccagtcgggc tgacagtgag gacaacctct cagaagagcc tgagatggag     2520

agcctgttcc ctgccctggc ttctctggct gtgacctcct ctgccaataa cgaggcatcc     2580

cctgtgtcct ccagtggagt cacctattct ccagaactac tggacctgta caccgtgaac     2640

ctgcaccgca ttgagaaaga tgtgcagagg tgtgaccgca gctactggta cttcacagca     2700

gccaacctgg agaagctgag gaacatcatg tgcagctata tctggcagca catcgagatc     2760

ggctacgtcc agggcatgtg tgacctcctg gccccgttgc tggtcatcct ggatgatgag     2820

gccctggcct tcagttgctt cacggagctg atgaagagga tgaaccaaaa cttcccccat     2880

ggaggcgcca tggatacgca cttcgccaac atgaggtctc tgatccagat cctggactcc     2940

gagctcttcg agctgatgca tcagaacggc gattacaccc acttctactt ttgctaccgc     3000

tggttcctgc tggatttcaa acgagagctg gtctatgatg acgtcttctc cgtgtgggaa     3060

actatctggg ctgctaagca cgtgtcctcc gcccactacg tgctgttcat cgcgctggcg     3120

ctggtggagg tctacagaga catcatcctg gagaacaata tggacttcac tgacattatc     3180

aagttcttca acgaaatggc tgagcggcac aacgccaagc agattctgca gctcgcccgg     3240

gacctcgtgc ataaggtgca gattctaatt gagaacaagt ga                        3282


<210>  3
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  3

Cys Val Met Asp Gly Trp Pro Gly Glu Ala Asp Lys Pro Ser Arg Ala 
1               5                   10                  15      


<210>  4
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nurr1 5' Primer

<400>  4
agagtcgacg gcagccatgc cttgtgttca ggcg                                   34


<210>  5
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nurr1 3' Primer

<400>  5
ctaggcggcc gcgggagaag gtcttagaaa ggtaa                                  35


<210>  6
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NLBD 5' Primer

<400>  6
tagagtcgac ccaggatccc tctcccccct cacct                                  35


<210>  7
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NLBD 583 3' Primer

<400>  7
ctagcggccg cttatggtac caagtcttcc aattt                                  35


<210>  8
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RXR 5' Primer

<400>  8
ctgggaattc acatggacac caaacatttc                                        30


<210>  9
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RXR 3' Primer

<400>  9
ctaagcggcc gcctaagtca tttggtgcgg                                        30


<210>  10
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NuIP 5' Primer

<400>  10
tagagtcgac ggaaccgggc accgaccagc ttgagcca                               38


<210>  11
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NuIP 3' Primer

<400>  11
ctagtctaga cttgttctca attagaatct g                                      31


<210>  12
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VP16/NuIP 5' Primer

<400>  12
tagagtcgac ggcaccgacc agcttcagcc a                                      31


<210>  13
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H1 5' Primer

<400>  13
agagtcgacc gaagagccca caggatccct ct                                     32


<210>  14
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H1 3' Primer

<400>  14
ctagtctaga atctccactc atctgatagt cagg                                   34


<210>  15
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H3 5' Primer

<400>  15
tagagtcgac atgataccca acatatccag cag                                    33


<210>  16
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H3 3' Primer

<400>  16
ctagtctaga gggagaaggt cttagaaagg taa                                    33


<210>  17
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NuIP Forward Primer

<400>  17
ttgaagtgga cacccaatca gc                                                22


<210>  18
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NuIP Reverse Primer

<400>  18
caggtctgga gacacgatca tgtg                                              24


<210>  19
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NuIPa Forward Primer

<400>  19
ctctggcttc ccacagtctc cc                                                22


<210>  20
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NuIPa Reverse Primer

<400>  20
caggtctgga gacacgatca tgtg                                              24


<210>  21
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NuIPa Reverse Primer

<400>  21
ctctggcttc ccacagtctc cc                                                22


<210>  22
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NuIPb Reverse Primer

<400>  22
gcttcttgca gacaacagca gg                                                22


<210>  23
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NuIPc Forward Primer

<400>  23
ttgaagtgga cacccaatca gc                                                22


<210>  24
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NuIPc Reverse Primer

<400>  24
gcttcttgca gacaacagca gg                                                22


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nurr1 Forward Primer

<400>  25
attccaatcc ggcaatgacc                                                   20


<210>  26
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nurr1 Reverse Primer

<400>  26
ttgcaacctg tgcaagacca c                                                 21


<210>  27
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NuIP siRNA 1

<400>  27
gtaccagatc ctctccaga                                                    19


<210>  28
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NuIP siRNA 2

<400>  28
cccgggacct cgtgcataa                                                    19


<210>  29
<211>  146
<212>  PRT
<213>  Mus musculus

<400>  29

Ser Phe Cys Ala Ala Val Glu Ala Cys Val Leu His Gly Leu Arg Arg 
1               5                   10                  15      


Arg Ala Ala Gly Phe Leu Arg Ser Asn Lys Ile Ala Ala Leu Phe Met 
            20                  25                  30          


Lys Val Gly Lys Gly Phe Pro Pro Ala Glu Glu Leu Ser Arg Lys Val 
        35                  40                  45              


Gln Glu Leu Glu Gln Leu Ile Glu Ser Ala Arg Asn Gln Ile Gln Gly 
    50                  55                  60                  


Leu Gln Glu Asn Val Arg Lys Leu Pro Lys Leu Pro Asn Leu Ser Pro 
65                  70                  75                  80  


Leu Ala Ile Lys His Leu Trp Ile Arg Thr Ala Leu Phe Glu Arg Val 
                85                  90                  95      


Leu Asp Lys Ile Val His Tyr Leu Val Glu Asn Ser Ser Lys Tyr Tyr 
            100                 105                 110         


Glu Lys Glu Ala Leu Leu Met Asp Pro Val Asp Gly Pro Ile Leu Ala 
        115                 120                 125             


Ser Leu Leu Val Gly Pro Cys Ala Leu Glu Tyr Thr Lys Met Lys Thr 
    130                 135                 140                 


Ala Asp 
145     


<210>  30
<211>  173
<212>  PRT
<213>  Mus musculus

<400>  30

Leu His Arg Ile Glu Lys Asp Val Gln Arg Cys Asp Arg Ser Tyr Trp 
1               5                   10                  15      


Tyr Phe Thr Ala Ala Asn Leu Glu Lys Leu Arg Asn Ile Met Cys Ser 
            20                  25                  30          


Tyr Ile Trp Gln His Ile Glu Ile Gly Tyr Val Gln Gly Met Cys Asp 
        35                  40                  45              


Leu Leu Ala Pro Leu Leu Val Ile Leu Asp Asp Glu Ala Leu Ala Phe 
    50                  55                  60                  


Ser Cys Phe Thr Glu Leu Met Lys Arg Met Asn Gln Asn Phe Pro His 
65                  70                  75                  80  


Gly Gly Ala Met Asp Thr His Phe Ala Asn Met Arg Ser Leu Ile Gln 
                85                  90                  95      


Ile Leu Asp Ser Glu Leu Phe Glu Leu Met His Gln Asn Gly Asp Tyr 
            100                 105                 110         


Thr His Phe Tyr Phe Cys Tyr Arg Trp Phe Leu Leu Asp Phe Lys Arg 
        115                 120                 125             


Glu Leu Val Tyr Asp Asp Val Phe Ser Val Trp Glu Thr Ile Trp Ala 
    130                 135                 140                 


Ala Lys His Val Ser Ser Ala His Tyr Val Leu Phe Ile Ala Leu Ala 
145                 150                 155                 160 


Leu Val Glu Val Tyr Arg Asp Ile Ile Leu Glu Asn Asn 
                165                 170             


<210>  31
<211>  598
<212>  PRT
<213>  Mus musculus

<400>  31

Met Pro Cys Val Gln Ala Gln Tyr Gly Ser Ser Pro Gln Gly Ala Ser 
1               5                   10                  15      


Pro Ala Ser Gln Ser Tyr Ser Tyr His Ser Ser Gly Glu Tyr Ser Ser 
            20                  25                  30          


Asp Phe Leu Thr Pro Glu Phe Val Lys Phe Ser Met Asp Leu Thr Asn 
        35                  40                  45              


Thr Glu Ile Thr Ala Thr Thr Ser Leu Pro Ser Phe Ser Thr Phe Met 
    50                  55                  60                  


Asp Asn Tyr Ser Thr Gly Tyr Asp Val Lys Pro Pro Cys Leu Tyr Gln 
65                  70                  75                  80  


Met Pro Leu Ser Gly Gln Gln Ser Ser Ile Lys Val Glu Asp Ile Gln 
                85                  90                  95      


Met His Asn Tyr Gln Gln His Ser His Leu Pro Pro Gln Ser Glu Glu 
            100                 105                 110         


Met Met Pro His Ser Gly Ser Val Tyr Tyr Lys Pro Ser Ser Pro Pro 
        115                 120                 125             


Thr Pro Ser Thr Pro Ser Phe Gln Val Gln His Ser Pro Met Trp Asp 
    130                 135                 140                 


Asp Pro Gly Ser Leu His Asn Phe His Gln Asn Tyr Val Ala Thr Thr 
145                 150                 155                 160 


His Met Ile Glu Gln Arg Lys Thr Pro Val Ser Arg Leu Ser Leu Phe 
                165                 170                 175     


Ser Phe Lys Gln Ser Pro Pro Gly Thr Pro Val Ser Ser Cys Gln Met 
            180                 185                 190         


Arg Phe Asp Gly Pro Leu His Val Pro Met Asn Pro Glu Pro Ala Gly 
        195                 200                 205             


Ser His His Val Val Asp Gly Gln Thr Phe Ala Val Pro Asn Pro Ile 
    210                 215                 220                 


Arg Lys Pro Ala Ser Met Gly Phe Pro Gly Leu Gln Ile Gly His Ala 
225                 230                 235                 240 


Ser Gln Leu Leu Asp Thr Gln Val Pro Ser Pro Pro Ser Arg Gly Ser 
                245                 250                 255     


Pro Ser Asn Glu Gly Leu Cys Ala Val Cys Gly Asp Asn Ala Ala Cys 
            260                 265                 270         


Gln His Tyr Gly Val Arg Thr Cys Glu Gly Cys Lys Gly Phe Phe Lys 
        275                 280                 285             


Arg Thr Val Gln Lys Asn Ala Lys Tyr Val Cys Leu Ala Asn Lys Asn 
    290                 295                 300                 


Cys Pro Val Asp Lys Arg Arg Arg Asn Arg Cys Gln Tyr Cys Arg Phe 
305                 310                 315                 320 


Gln Lys Cys Leu Ala Val Gly Met Val Lys Glu Val Val Arg Thr Asp 
                325                 330                 335     


Ser Leu Lys Gly Arg Arg Gly Arg Leu Pro Ser Lys Pro Lys Ser Pro 
            340                 345                 350         


Gln Asp Pro Ser Pro Pro Ser Pro Pro Val Ser Leu Ile Ser Ala Leu 
        355                 360                 365             


Val Arg Ala His Val Asp Ser Asn Pro Ala Met Thr Ser Leu Asp Tyr 
    370                 375                 380                 


Ser Arg Phe Gln Ala Asn Pro Asp Tyr Gln Met Ser Gly Asp Asp Thr 
385                 390                 395                 400 


Gln His Ile Gln Gln Phe Tyr Asp Leu Leu Thr Gly Ser Met Glu Ile 
                405                 410                 415     


Ile Arg Gly Trp Ala Glu Lys Ile Pro Gly Phe Ala Asp Leu Pro Lys 
            420                 425                 430         


Ala Asp Gln Asp Leu Leu Phe Glu Ser Ala Phe Leu Glu Leu Phe Val 
        435                 440                 445             


Leu Arg Leu Ala Tyr Arg Ser Asn Pro Val Glu Gly Lys Leu Ile Phe 
    450                 455                 460                 


Cys Asn Gly Val Val Leu His Arg Leu Gln Cys Val Arg Gly Phe Gly 
465                 470                 475                 480 


Glu Trp Ile Asp Ser Ile Val Glu Phe Ser Ser Asn Leu Gln Asn Met 
                485                 490                 495     


Asn Ile Asp Ile Ser Ala Phe Ser Cys Ile Ala Ala Leu Ala Met Val 
            500                 505                 510         


Thr Glu Arg His Gly Leu Lys Glu Pro Lys Arg Val Glu Glu Leu Gln 
        515                 520                 525             


Asn Lys Ile Val Asn Cys Leu Lys Asp His Val Thr Phe Asn Asn Gly 
    530                 535                 540                 


Gly Leu Asn Arg Pro Asn Tyr Leu Ser Lys Leu Leu Gly Lys Leu Pro 
545                 550                 555                 560 


Glu Leu Arg Thr Leu Cys Thr Gln Gly Leu Gln Arg Ile Phe Tyr Leu 
                565                 570                 575     


Lys Leu Glu Asp Leu Val Pro Pro Pro Ala Ile Ile Asp Lys Leu Phe 
            580                 585                 590         


Leu Asp Thr Leu Pro Phe 
        595             


<210>  32
<211>  245
<212>  PRT
<213>  Mus musculus

<400>  32

Asp Pro Ser Pro Pro Ser Pro Pro Val Ser Leu Ile Ser Ala Leu Val 
1               5                   10                  15      


Arg Ala His Val Asp Ser Asn Pro Ala Met Thr Ser Leu Asp Tyr Ser 
            20                  25                  30          


Arg Phe Gln Ala Asn Pro Asp Tyr Gln Met Ser Gly Asp Asp Thr Gln 
        35                  40                  45              


His Ile Gln Gln Phe Tyr Asp Leu Leu Thr Gly Ser Met Glu Ile Ile 
    50                  55                  60                  


Arg Gly Trp Ala Glu Lys Ile Pro Gly Phe Ala Asp Leu Pro Lys Ala 
65                  70                  75                  80  


Asp Gln Asp Leu Leu Phe Glu Ser Ala Phe Leu Glu Leu Phe Val Leu 
                85                  90                  95      


Arg Leu Ala Tyr Arg Ser Asn Pro Val Glu Gly Lys Leu Ile Phe Cys 
            100                 105                 110         


Asn Gly Val Val Leu His Arg Leu Gln Cys Val Arg Gly Phe Gly Glu 
        115                 120                 125             


Trp Ile Asp Ser Ile Val Glu Phe Ser Ser Asn Leu Gln Asn Met Asn 
    130                 135                 140                 


Ile Asp Ile Ser Ala Phe Ser Cys Ile Ala Ala Leu Ala Met Val Thr 
145                 150                 155                 160 


Glu Arg His Gly Leu Lys Glu Pro Lys Arg Val Glu Glu Leu Gln Asn 
                165                 170                 175     


Lys Ile Val Asn Cys Leu Lys Asp His Val Thr Phe Asn Asn Gly Gly 
            180                 185                 190         


Leu Asn Arg Pro Asn Tyr Leu Ser Lys Leu Leu Gly Lys Leu Pro Glu 
        195                 200                 205             


Leu Arg Thr Leu Cys Thr Gln Gly Leu Gln Arg Ile Phe Tyr Leu Lys 
    210                 215                 220                 


Leu Glu Asp Leu Val Pro Pro Pro Ala Ile Ile Asp Lys Leu Phe Leu 
225                 230                 235                 240 


Asp Thr Leu Pro Phe 
                245 


<210>  33
<211>  230
<212>  PRT
<213>  Mus musculus

<400>  33

Asp Pro Ser Pro Pro Ser Pro Pro Val Ser Leu Ile Ser Ala Leu Val 
1               5                   10                  15      


Arg Ala His Val Asp Ser Asn Pro Ala Met Thr Ser Leu Asp Tyr Ser 
            20                  25                  30          


Arg Phe Gln Ala Asn Pro Asp Tyr Gln Met Ser Gly Asp Asp Thr Gln 
        35                  40                  45              


His Ile Gln Gln Phe Tyr Asp Leu Leu Thr Gly Ser Met Glu Ile Ile 
    50                  55                  60                  


Arg Gly Trp Ala Glu Lys Ile Pro Gly Phe Ala Asp Leu Pro Lys Ala 
65                  70                  75                  80  


Asp Gln Asp Leu Leu Phe Glu Ser Ala Phe Leu Glu Leu Phe Val Leu 
                85                  90                  95      


Arg Leu Ala Tyr Arg Ser Asn Pro Val Glu Gly Lys Leu Ile Phe Cys 
            100                 105                 110         


Asn Gly Val Val Leu His Arg Leu Gln Cys Val Arg Gly Phe Gly Glu 
        115                 120                 125             


Trp Ile Asp Ser Ile Val Glu Phe Ser Ser Asn Leu Gln Asn Met Asn 
    130                 135                 140                 


Ile Asp Ile Ser Ala Phe Ser Cys Ile Ala Ala Leu Ala Met Val Thr 
145                 150                 155                 160 


Glu Arg His Gly Leu Lys Glu Pro Lys Arg Val Glu Glu Leu Gln Asn 
                165                 170                 175     


Lys Ile Val Asn Cys Leu Lys Asp His Val Thr Phe Asn Asn Gly Gly 
            180                 185                 190         


Leu Asn Arg Pro Asn Tyr Leu Ser Lys Leu Leu Gly Lys Leu Pro Glu 
        195                 200                 205             


Leu Arg Thr Leu Cys Thr Gln Gly Leu Gln Arg Ile Phe Tyr Leu Lys 
    210                 215                 220                 


Leu Glu Asp Leu Val Pro 
225                 230 


<210>  34
<211>  598
<212>  PRT
<213>  Mus musculus

<400>  34

Met Pro Cys Val Gln Ala Gln Tyr Gly Ser Ser Pro Gln Gly Ala Ser 
1               5                   10                  15      


Pro Ala Ser Gln Ser Tyr Ser Tyr His Ser Ser Gly Glu Tyr Ser Ser 
            20                  25                  30          


Asp Phe Leu Thr Pro Glu Phe Val Lys Phe Ser Met Asp Leu Thr Asn 
        35                  40                  45              


Thr Glu Ile Thr Ala Thr Thr Ser Leu Pro Ser Phe Ser Thr Phe Met 
    50                  55                  60                  


Asp Asn Tyr Ser Thr Gly Tyr Asp Val Lys Pro Pro Cys Leu Tyr Gln 
65                  70                  75                  80  


Met Pro Leu Ser Gly Gln Gln Ser Ser Ile Lys Val Glu Asp Ile Gln 
                85                  90                  95      


Met His Asn Tyr Gln Gln His Ser His Leu Pro Pro Gln Ser Glu Glu 
            100                 105                 110         


Met Met Pro His Ser Gly Ser Val Tyr Tyr Lys Pro Ser Ser Pro Pro 
        115                 120                 125             


Thr Pro Ser Thr Pro Ser Phe Gln Val Gln His Ser Pro Met Trp Asp 
    130                 135                 140                 


Asp Pro Gly Ser Leu His Asn Phe His Gln Asn Tyr Val Ala Thr Thr 
145                 150                 155                 160 


His Met Ile Glu Gln Arg Lys Thr Pro Val Ser Arg Leu Ser Leu Phe 
                165                 170                 175     


Ser Phe Lys Gln Ser Pro Pro Gly Thr Pro Val Ser Ser Cys Gln Met 
            180                 185                 190         


Arg Phe Asp Gly Pro Leu His Val Pro Met Asn Pro Glu Pro Ala Gly 
        195                 200                 205             


Ser His His Val Val Asp Gly Gln Thr Phe Ala Val Pro Asn Pro Ile 
    210                 215                 220                 


Arg Lys Pro Ala Ser Met Gly Phe Pro Gly Leu Gln Ile Gly His Ala 
225                 230                 235                 240 


Ser Gln Leu Leu Asp Thr Gln Val Pro Ser Pro Pro Ser Arg Gly Ser 
                245                 250                 255     


Pro Ser Asn Glu Gly Leu Cys Ala Val Cys Gly Asp Asn Ala Ala Cys 
            260                 265                 270         


Gln His Tyr Gly Val Arg Thr Cys Glu Gly Cys Lys Gly Phe Phe Lys 
        275                 280                 285             


Arg Thr Val Gln Lys Asn Ala Lys Tyr Val Cys Leu Ala Asn Lys Asn 
    290                 295                 300                 


Cys Pro Val Asp Lys Arg Arg Arg Asn Arg Cys Gln Tyr Cys Arg Phe 
305                 310                 315                 320 


Gln Lys Cys Leu Ala Val Gly Met Val Lys Glu Val Val Arg Thr Asp 
                325                 330                 335     


Ser Leu Lys Gly Arg Arg Gly Arg Leu Pro Ser Lys Pro Lys Ser Pro 
            340                 345                 350         


Gln Asp Pro Ser Pro Pro Ser Pro Pro Val Ser Leu Ile Ser Ala Leu 
        355                 360                 365             


Val Arg Ala His Val Asp Ser Asn Pro Ala Met Thr Ser Leu Asp Tyr 
    370                 375                 380                 


Ser Arg Phe Gln Ala Asn Pro Asp Tyr Gln Met Ser Gly Asp Asp Thr 
385                 390                 395                 400 


Gln His Ile Gln Gln Phe Tyr Asp Leu Leu Thr Gly Ser Met Glu Ile 
                405                 410                 415     


Ile Arg Gly Trp Ala Glu Lys Ile Pro Gly Phe Ala Asp Leu Pro Lys 
            420                 425                 430         


Ala Asp Gln Asp Leu Leu Phe Glu Ser Ala Phe Leu Glu Leu Phe Val 
        435                 440                 445             


Leu Arg Leu Ala Tyr Arg Ser Asn Pro Val Glu Gly Lys Leu Ile Phe 
    450                 455                 460                 


Cys Asn Gly Val Val Leu His Arg Leu Gln Cys Val Arg Gly Phe Gly 
465                 470                 475                 480 


Glu Trp Ile Asp Ser Ile Val Glu Phe Ser Ser Asn Leu Gln Asn Met 
                485                 490                 495     


Asn Ile Asp Ile Ser Ala Phe Ser Cys Ile Ala Ala Leu Ala Met Val 
            500                 505                 510         


Thr Glu Arg His Gly Leu Lys Glu Pro Lys Arg Val Glu Glu Leu Gln 
        515                 520                 525             


Asn Lys Ile Val Asn Cys Leu Lys Asp His Val Thr Phe Asn Asn Gly 
    530                 535                 540                 


Gly Leu Asn Arg Pro Asn Tyr Leu Ser Lys Leu Leu Gly Lys Leu Pro 
545                 550                 555                 560 


Glu Leu Arg Thr Leu Cys Thr Gln Gly Leu Gln Arg Ile Phe Tyr Leu 
                565                 570                 575     


Lys Leu Glu Asp Leu Val Pro Pro Pro Ala Ile Ile Ala Lys Leu Phe 
            580                 585                 590         


Leu Asp Thr Leu Pro Phe 
        595             


<210>  35
<211>  245
<212>  PRT
<213>  Mus musculus

<400>  35

Asp Pro Ser Pro Pro Ser Pro Pro Val Ser Leu Ile Ser Ala Leu Val 
1               5                   10                  15      


Arg Ala His Val Asp Ser Asn Pro Ala Met Thr Ser Leu Asp Tyr Ser 
            20                  25                  30          


Arg Phe Gln Ala Asn Pro Asp Tyr Gln Met Ser Gly Asp Asp Thr Gln 
        35                  40                  45              


His Ile Gln Gln Phe Tyr Asp Leu Leu Thr Gly Ser Met Glu Ile Ile 
    50                  55                  60                  


Arg Gly Trp Ala Glu Lys Ile Pro Gly Phe Ala Asp Leu Pro Lys Ala 
65                  70                  75                  80  


Asp Gln Asp Leu Leu Phe Glu Ser Ala Phe Leu Glu Leu Phe Val Leu 
                85                  90                  95      


Arg Leu Ala Tyr Arg Ser Asn Pro Val Glu Gly Lys Leu Ile Phe Cys 
            100                 105                 110         


Asn Gly Val Val Leu His Arg Leu Gln Cys Val Arg Gly Phe Gly Glu 
        115                 120                 125             


Trp Ile Asp Ser Ile Val Glu Phe Ser Ser Asn Leu Gln Asn Met Asn 
    130                 135                 140                 


Ile Asp Ile Ser Ala Phe Ser Cys Ile Ala Ala Leu Ala Met Val Thr 
145                 150                 155                 160 


Glu Arg His Gly Leu Lys Glu Pro Lys Arg Val Glu Glu Leu Gln Asn 
                165                 170                 175     


Lys Ile Val Asn Cys Leu Lys Asp His Val Thr Phe Asn Asn Gly Gly 
            180                 185                 190         


Leu Asn Arg Pro Asn Tyr Leu Ser Lys Leu Leu Gly Lys Leu Pro Glu 
        195                 200                 205             


Leu Arg Thr Leu Cys Thr Gln Gly Leu Gln Arg Ile Phe Tyr Leu Lys 
    210                 215                 220                 


Leu Glu Asp Leu Val Pro Pro Pro Ala Ile Ile Ala Lys Leu Phe Leu 
225                 230                 235                 240 


Asp Thr Leu Pro Phe 
                245 


