                         SEQUENCE LISTING

<110>  University of the West of Scotland
       University of Strathclyde
       Henriquez, Fiona
       Roberts, Craig
 
<120>  Anti-Protozoa compounds

<130>  P108078.WO.01

<150>  GB0816854.4
<151>  2008-09-15

<160>  26    

<170>  PatentIn version 3.3

<210>  1
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide (forward primer)

<400>  1
gaaaagaggg aggcacaggt                                                 20


<210>  2
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide (reverse primer)

<400>  2
atcactcgag tacgcccttg g                                               21


<210>  3
<211>  659
<212>  DNA
<213>  Acanthamoeba castellanii

<400>  3
gaaaaggtaa aggaaattaa accatgaaaa gaaaaaggac aagaaatata taattgcaag     60

agagatggaa aagagggagg cacaggtggc gcgagagact ggggagacca agatcgaggt    120

gcgtctgtcg ctcgatggca cgggcgtgtc cgatgtgaag accggcatcg gcttcctgga    180

ccacatgctg tccgccctcg ccaagcatgg tcgcttcgat ctctatctcc gatgcgcggg    240

cgatctccac gtagacgacc accacacctc cgaggactgc gcgatcgtgc tgggccaagc    300

cttccgccag gctattggtg agcgtaaggg catcaagcgt tatgggtcgg cctacgcgcc    360

gctggacgag agcctggcgc gcgccgtggt ggacatctcg tcgcgcccgt tcgccgtgat    420

cgacctcaag ctcaagcggg agaagatcgg agagctctcg tgcgagatga tccctcacgt    480

ccttcactcc ttcgccacca gcgccaacct cacacttcac gttgaggtcc tgtacggtgc    540

gaatgaccac cacaaggccg aatcggcatt caaggccact gcgctggccc tgcgcgaggc    600

tgtgaccaaa gacggtcccg ccgacgccgt gcccagcacc aagggcgtac tcgagtgat     659


<210>  4
<211>  227
<212>  DNA
<213>  Acanthamoeba castellanii

<400>  4
gatcgagggc aggcccgcga tgaccgactc caggcacgac ttctcgacgt tgaactcgat     60

cagggccttc tcgcgggcgt tgagcgccga ctgcaggagg atcacgaact cgtccaacgc    120

cgcgtgctta cgcgggtcct ccagcgcggt gcggttgatg cagaggaagg tggaggactt    180

ggtgatctca tcgacgatgg ccagctggtt ggcccgcagg gtggtgc                  227


<210>  5
<211>  120
<212>  DNA
<213>  Acanthamoeba castellanii

<400>  5
gagctcgccg atgctgaagg caaggagcac atcgccaacg aggctgccga tcttctctac     60

tttgcgctgg tggcctgcac caaggccggc gtcaccctgt ccgacgtcga gcacgtcctt    120


<210>  6
<211>  116
<212>  DNA
<213>  Acanthamoeba castellanii

<400>  6
gccgtgcctg gcgtccagcg cgaccaccac gcgctccctg ggcagctgcc gcaggaagtc     60

gggcttggcg gccgtgccga tccccacctt ggcagcgcca gcgtttagcc aatcac        116


<210>  7
<211>  359
<212>  DNA
<213>  Acanthamoeba castellanii

<400>  7
atggaaaaga gggaggcaca ggtggcacga gagacggggg agaccaagat cgaggtgcgc     60

ctgtcgctcg acggcacggg cgtgtccgat gtgaagaccg gcatcggctt cctggaccac    120

atgctgtccg ccctcgccaa gcacggtcgc ttcgatctct atctccgatg cgcgggcgat    180

ctccacgtcg acgaccacca cacctccgag gactgcgcga tcgtgctggg ccaagccttc    240

cgccaggcca tcggtgagcg taagggcatc aagcggtacg ggtcggccta cgcgccgctg    300

gacgagagcc tggcgcgcgc cgtggtggac atctcgtctc ccccgtctct cgcgaatct     359


<210>  8
<211>  297
<212>  DNA
<213>  Acanthamoeba castellanii

<400>  8
acatgctcgc cggtccctcc gagtgcctcg tgctagccga cggcacggcc cacccggacg     60

tcgtggcggc cgacctgctg gcccaggccg agcacgacgt ggcggccgtg cccatcttgg    120

tggcctacga cgaggagacc gtgcgccggg tcgaacagga ggtcgaggct cagctcgcca    180

ccctgcccac cgctgccatc gcccgcgccg ccttctccaa cggttttgct gtgattgtcg    240

cgaacgaaga ggaggccatc acggtgtgcg acaagctcgc gcccgagcac ttggagg       297


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide: A. castellanii CGS forward primer

<400>  9
atttggatgg agtcgccgac c                                               21


<210>  10
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide: A. castellanii CGS reverse primer

<400>  10
cttggtcacc gagtggacg                                                  19


<210>  11
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide: MS1 forward primer

<400>  11
aagcgcgagg ggatgaggcc gag                                             23


<210>  12
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide: MS1 reverse primer

<400>  12
gtcgccacgg gcaccatcgg c                                               21


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide: MS2 forward primer

<400>  13
tgccagacgt tgcgggcatc                                                 20


<210>  14
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide: MS2 reverse primer

<400>  14
ccagggcgct gcacatgac                                                  19


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide: MS5 forward primer

<400>  15
gactcgtact cggcccgcag g                                               21


<210>  16
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide: MS5 reverse primer

<400>  16
atcgacgcgc tcgatgccg                                                  19


<210>  17
<211>  174
<212>  DNA
<213>  Acanthamoeba castellanii

<400>  17
atttggatgg agtcgccgac caacccgacc ctcaagctca ccgacatccg caaggtggcg     60

gaggtggcca agaagaggaa catcctgctg gtcgtggacg acaccttcat gtcgccctac    120

ttccagaacc ccctcgacct cggcgccgac atcgtcgtcc actcggtgac caag          174


<210>  18
<211>  188
<212>  DNA
<213>  Acanthamoeba castellanii

<400>  18
gttgatgaca tcatcagcaa gctcgccgcc atccgcgcgt cgttcgaggg caagctggtg     60

gtccagccct cggcgtcgct tcagcacgtg ccctacgatg ccaccgtgga gaccaagctg    120

ccctcggccc tgcgccaggt ccttgccttc gccttccaga agctcaagga ggtcgacttc    180

atcgctag                                                             188


<210>  19
<211>  245
<212>  DNA
<213>  Acanthamoeba castellanii

<400>  19
gtcgccacgg gcaccatcgg cttcccgcgt gtgggcaagg accgagagct taagaaggcg     60

ctcgagtcct actgggccgg caccaccgac cgtacccatt tgctcggcgt ggccgcccag    120

gtcgagaagg ccaacctcct cgcccaggtc gacgccggca tcgagcgcat cggcgtaggc    180

agcttcagcc tctacgacca ggtcctcgac tgggccttcc gcctcggcct catcccctcg    240

cgctt                                                                245


<210>  20
<211>  308
<212>  DNA
<213>  Acanthamoeba castellanii

<400>  20
atcgacgcgc tcgatgccga tgtgatctcg atcgagaact cgcgtaacaa cgacaagacg     60

attaaggacc tcaccgccta cggctacgag cgcgacatcg gccccggcgt gtacgacatc    120

cacagcccgg tggtgcccac cgtcgacgag attgtcgaga agctgcgcct cttcctcaag    180

cacctccacc cgtcgcgcgt cgtggtcaac cccgactgcg gcctcaagac ccgccagtgg    240

aaggaggtcg tgccgtcgct gcgcaacatg gtcaccgccg ccagcatcct gcgggccgag    300

tacgagtc                                                             308


<210>  21
<211>  181
<212>  PRT
<213>  Acanthamoeba castellanii

<400>  21

Met Glu Lys Arg Glu Ala Gln Val Ala Arg Glu Thr Gly Glu Thr Lys 
1               5                   10                  15      


Ile Glu Val Arg Leu Ser Leu Asp Gly Thr Gly Val Ser Asp Val Lys 
            20                  25                  30          


Thr Gly Ile Gly Phe Leu Asp His Met Leu Ser Ala Leu Ala Lys His 
        35                  40                  45              


Gly Arg Phe Asp Leu Tyr Leu Arg Cys Ala Gly Asp Leu His Val Asp 
    50                  55                  60                  


Asp His His Thr Ser Glu Asp Cys Ala Ile Val Leu Gly Gln Ala Phe 
65                  70                  75                  80  


Arg Gln Ala Ile Gly Glu Arg Lys Gly Ile Lys Arg Tyr Gly Ser Ala 
                85                  90                  95      


Tyr Ala Pro Leu Asp Glu Ser Leu Ala Arg Ala Val Val Asp Ile Ser 
            100                 105                 110         


Ser Arg Pro Phe Ala Val Ile Asp Leu Lys Leu Lys Arg Glu Lys Ile 
        115                 120                 125             


Gly Glu Leu Ser Cys Glu Met Ile Pro His Val Leu His Ser Phe Ala 
    130                 135                 140                 


Thr Ser Ala Asn Leu Thr Leu His Val Glu Val Arg His Arg Val Trp 
145                 150                 155                 160 


Cys Ala Cys Gly Cys Val Cys Val Cys Val Cys Val Cys Val Ile Val 
                165                 170                 175     


Arg Val Arg Val Arg 
            180     


<210>  22
<211>  247
<212>  PRT
<213>  Aspergillus nidulans

<400>  22

Met Pro Leu Pro Ala Arg Thr Ala Ser Leu Ser Arg Asn Thr Asn Glu 
1               5                   10                  15      


Thr Lys Ile Gln Val Ser Leu Ser Leu Asp Gly Gly Val Leu Pro Pro 
            20                  25                  30          


Tyr Glu Pro Ser Ser His Phe Pro Val Pro Thr Asp Pro Leu Glu Ala 
        35                  40                  45              


Glu Ala Ala Lys Lys Gly Ile Val Pro Asn Lys Asp Ala Ala His Ala 
    50                  55                  60                  


Thr Gln Phe Thr Pro Thr Gln Gln Ile Thr Ile Ser Thr Gly Ile Gly 
65                  70                  75                  80  


Phe Leu Asp His Met Leu His Ala Leu Ala Lys His Ser Gly Trp Ser 
                85                  90                  95      


Leu Ala Ile Arg Ala Lys Gly Asp Leu Tyr Ile Asp Asp His His Thr 
            100                 105                 110         


Thr Glu Asp Thr Phe Leu Ala Leu Gly Thr Ala Phe Thr Thr Ala Leu 
        115                 120                 125             


Gly Ala Arg Gln Ser Leu Ala Arg Phe Gly Arg Gly Asp Ala Pro Leu 
    130                 135                 140                 


Asp Glu Ala Leu Ser Trp Ala Val Ile Asp Leu Ser Ser Arg Pro Trp 
145                 150                 155                 160 


Ala Val Ile Asn Ile Gly Phe Lys Arg Glu Lys Ile Gly Asp Leu Ser 
                165                 170                 175     


Thr Glu Met Ile Thr His Gly Leu Gln Ser Phe Ala Gln Ala Ala Gly 
            180                 185                 190         


Val Thr Leu His Ile Gly Cys Thr Tyr Gly Asp Asn Asp His His Arg 
        195                 200                 205             


Ala Glu Ser Ala Phe Lys Ala Leu Ala Val Ala Ile Arg Ala Ala Cys 
    210                 215                 220                 


Ala Arg Arg Val Glu Gly Glu Val Gly Ala Gly Asp Val Ser Gly Thr 
225                 230                 235                 240 


Lys Gly Pro Ala Leu Ile Glu 
                245         


<210>  23
<211>  292
<212>  PRT
<213>  Oryza sativa

<400>  23

Met Thr Thr Ala Arg Phe Val Ser Pro Ser Leu Ser Arg Val Ser Pro 
1               5                   10                  15      


Ser Pro Ala Gly Arg Val Ser Gly Ser Ser Trp Leu Ser Arg Ala Gly 
            20                  25                  30          


Val Ala Leu Pro Ala Arg Pro His Gly Leu Ser Leu His Leu Arg Pro 
        35                  40                  45              


Pro Ala Met Ala Ser Ala Ala Ala Ala Gly Asn Gly Ser Pro Ser Ala 
    50                  55                  60                  


Pro Glu Asp Ser Thr Ala Leu Ser Arg Ile Gly Glu Val Lys Arg Val 
65                  70                  75                  80  


Thr Lys Glu Thr Asn Val His Val Lys Ile Asn Leu Asp Gly Thr Gly 
                85                  90                  95      


Val Ala Asp Cys Ser Thr Gly Ile Pro Phe Leu Asp His Met Leu Asp 
            100                 105                 110         


Gln Leu Ala Ser His Gly Leu Phe Asp Val Cys Val Lys Ala Lys Gly 
        115                 120                 125             


Asp Thr His Ile Asp Asp His His Ser Asn Glu Asp Ile Ala Leu Ala 
    130                 135                 140                 


Ile Gly Thr Ala Leu Leu Glu Ala Leu Gly Asp Arg Lys Gly Ile Asn 
145                 150                 155                 160 


Arg Phe Gly His Phe Thr Ala Pro Leu Asp Glu Ala Ala Val Glu Val 
                165                 170                 175     


Ile Leu Asp Leu Ser Gly Arg Pro His Leu Ser Cys Gly Leu Ser Ile 
            180                 185                 190         


Pro Thr Glu Arg Val Gly Thr Tyr Asp Thr Gln Leu Val Glu His Phe 
        195                 200                 205             


Phe Gln Ser Leu Val Asn Thr Ser Gly Met Thr Leu His Ile Arg Gln 
    210                 215                 220                 


Leu Ala Gly Lys Asn Ser His His Ile Ile Glu Ala Thr Phe Lys Ala 
225                 230                 235                 240 


Phe Ala Arg Ala Leu Arg Gln Ala Thr Glu Tyr Asp Leu Arg Arg Arg 
                245                 250                 255     


Gly Thr Val Pro Arg Leu Gln Tyr Ser Lys Glu Thr Asn Gly Met Ala 
            260                 265                 270         


Ser Thr Ala Pro Arg Phe Leu Leu Thr Leu Gly Ile Ser Val Gly Cys 
        275                 280                 285             


Asp Asn Arg Thr 
    290         


<210>  24
<211>  220
<212>  PRT
<213>  Asphodelus aestivus

<400>  24

Met Thr Glu Gln Lys Ala Leu Val Lys Arg Ile Thr Asn Glu Thr Lys 
1               5                   10                  15      


Ile Gln Ile Ala Ile Ser Leu Lys Gly Gly Pro Leu Ala Ile Glu His 
            20                  25                  30          


Ser Ile Phe Pro Glu Lys Glu Ala Glu Ala Val Ala Glu Gln Ala Thr 
        35                  40                  45              


Gln Ser Gln Val Ile Asn Val His Thr Gly Ile Gly Phe Leu Asp His 
    50                  55                  60                  


Met Ile His Ala Leu Ala Lys His Ser Gly Trp Ser Leu Ile Val Glu 
65                  70                  75                  80  


Cys Ile Gly Asp Leu His Ile Asp Asp His His Thr Thr Glu Asp Cys 
                85                  90                  95      


Gly Ile Ala Leu Gly Gln Ala Phe Lys Glu Ala Leu Gly Ala Val Arg 
            100                 105                 110         


Gly Val Lys Arg Phe Gly Ser Gly Phe Ala Pro Leu Asp Glu Ala Leu 
        115                 120                 125             


Ser Arg Ala Val Val Asp Leu Ser Asn Arg Pro Tyr Ala Val Val Glu 
    130                 135                 140                 


Leu Gly Leu Gln Arg Glu Lys Val Gly Asp Leu Ser Cys Glu Met Ile 
145                 150                 155                 160 


Pro His Phe Leu Glu Ser Phe Ala Glu Ala Ser Arg Ile Thr Leu His 
                165                 170                 175     


Val Asp Cys Leu Arg Gly Lys Asn Asp His His Arg Ser Glu Ser Ala 
            180                 185                 190         


Phe Lys Ala Leu Ala Val Ala Ile Arg Glu Ala Thr Ser Pro Asn Gly 
        195                 200                 205             


Thr Asn Asp Val Pro Ser Thr Lys Gly Val Leu Met 
    210                 215                 220 


<210>  25
<211>  244
<212>  PRT
<213>  Aspergillus fumigatus

<400>  25

Met Pro Leu Pro Ala Arg Thr Ala Thr Val Ser Arg Val Thr Asn Glu 
1               5                   10                  15      


Thr Lys Ile Gln Val Ser Leu Ser Leu Asp Gly Gly Val Leu Pro Pro 
            20                  25                  30          


Tyr Glu Pro Ser Asp His Phe Pro Ala Pro Glu Asp Leu Lys Glu Ala 
        35                  40                  45              


Glu Ala Ala Lys His Gly Ile Val Pro Pro Lys Asn Ala Ala His Ala 
    50                  55                  60                  


Thr Gln Phe Thr Pro Thr Gln Gln Ile Thr Val Ser Thr Gly Ile Gly 
65                  70                  75                  80  


Phe Leu Asp His Met Leu His Ala Leu Ala Lys His Ser Gly Trp Ser 
                85                  90                  95      


Leu Ala Ile Arg Ala Lys Gly Asp Leu Tyr Ile Asp Asp His His Thr 
            100                 105                 110         


Thr Glu Asp Thr Phe Leu Ala Leu Gly Thr Ala Phe Thr Lys Ala Leu 
        115                 120                 125             


Gly Ala Arg Gln Ser Leu Ala Arg Phe Gly Arg Gly Asp Ala Pro Leu 
    130                 135                 140                 


Asp Glu Ala Leu Ser Trp Ala Val Ile Asp Leu Ser Ser Arg Pro Trp 
145                 150                 155                 160 


Ala Val Ile Asn Leu Gly Phe Lys Arg Glu Lys Ile Gly Asp Leu Ser 
                165                 170                 175     


Thr Glu Met Ile Thr His Gly Leu His Ser Phe Ala Gln Ala Ala Asp 
            180                 185                 190         


Val Thr Leu His Val Gly Cys Thr Tyr Gly Asp Asn Asp His His Arg 
        195                 200                 205             


Ala Glu Ser Ala Phe Lys Ala Leu Ala Val Ala Ile Arg Thr Ala Cys 
    210                 215                 220                 


Thr Arg Arg Val Ala Gly Glu Val Gly Ala Gly Asp Val Val Ser Thr 
225                 230                 235                 240 


Lys Gly Val Leu 
                


<210>  26
<211>  272
<212>  PRT
<213>  Arabidopsis thaliana

<400>  26

Met Glu Leu Leu Ser Ser Ser Pro Ala Gln Leu Leu Arg Pro Asn Leu 
1               5                   10                  15      


Ser Ser Arg Ala Leu Leu Pro Pro Arg Thr Ser Ile Ala Ser Ser His 
            20                  25                  30          


Pro Pro Pro Pro Arg Phe Leu Val Met Asn Ser Gln Ser Gln His Arg 
        35                  40                  45              


Pro Ser Ile Ser Cys Ala Ser Pro Pro Pro Gly Asp Asn Gly Phe Pro 
    50                  55                  60                  


Ala Ile Thr Thr Ala Ser Pro Ile Glu Ser Ala Arg Ile Gly Glu Val 
65                  70                  75                  80  


Lys Arg Glu Thr Lys Glu Thr Asn Val Ser Val Lys Ile Asn Leu Asp 
                85                  90                  95      


Gly His Gly Val Ser Asp Ser Ser Thr Gly Ile Pro Phe Leu Asp His 
            100                 105                 110         


Met Leu Asp Gln Leu Ala Ser His Gly Leu Phe Asp Val His Val Arg 
        115                 120                 125             


Ala Thr Gly Asp Thr His Ile Asp Asp His His Thr Asn Glu Asp Val 
    130                 135                 140                 


Ala Leu Ala Ile Gly Thr Ala Leu Leu Lys Ala Leu Gly Glu Arg Lys 
145                 150                 155                 160 


Gly Ile Asn Arg Phe Gly Asp Phe Thr Ala Pro Leu Asp Glu Ala Leu 
                165                 170                 175     


Ile His Val Ser Leu Asp Leu Ser Gly Arg Pro Tyr Leu Gly Tyr Asn 
            180                 185                 190         


Leu Glu Ile Pro Thr Gln Arg Val Gly Thr Tyr Asp Thr Gln Leu Val 
        195                 200                 205             


Glu His Phe Phe Gln Ser Leu Val Asn Thr Ser Gly Met Thr Leu His 
    210                 215                 220                 


Ile Arg Gln Leu Ala Gly Lys Asn Ser His His Ile Ile Glu Ala Thr 
225                 230                 235                 240 


Phe Lys Ala Phe Ala Arg Ala Leu Arg Gln Ala Thr Glu Ser Asp Pro 
                245                 250                 255     


Arg Arg Gly Gly Thr Ile Pro Ser Ser Lys Gly Val Leu Ser Arg Ser 
            260                 265                 270         


